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Aliases for MALRD1 Gene

Aliases for MALRD1 Gene

  • MAM And LDL Receptor Class A Domain Containing 1 2 3 5
  • C10orf112 3 4
  • MAM And LDL-Receptor Class A Domain-Containing Protein C10orf112 3
  • Chromosome 10 Open Reading Frame 112 2
  • Novel MAM Domain Containing Protein 3
  • BA265G8.2 3
  • DIET1 3

External Ids for MALRD1 Gene

Previous HGNC Symbols for MALRD1 Gene

  • C10orf112

Previous GeneCards Identifiers for MALRD1 Gene

  • GC10P019492

Summaries for MALRD1 Gene

GeneCards Summary for MALRD1 Gene

MALRD1 (MAM And LDL Receptor Class A Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is MAMDC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MALRD1 Gene

Genomics for MALRD1 Gene

Regulatory Elements for MALRD1 Gene

Enhancers for MALRD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MALRD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MALRD1 Gene

Chromosome:
10
Start:
19,046,931 bp from pter
End:
19,790,401 bp from pter
Size:
743,471 bases
Orientation:
Plus strand

Genomic View for MALRD1 Gene

Genes around MALRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MALRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MALRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MALRD1 Gene

Proteins for MALRD1 Gene

  • Protein details for MALRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYJ5-MALR1_HUMAN
    Recommended name:
    MAM and LDL-receptor class A domain-containing protein 1
    Protein Accession:
    Q5VYJ5
    Secondary Accessions:
    • B7ZBP2

    Protein attributes for MALRD1 Gene

    Size:
    1473 amino acids
    Molecular mass:
    163994 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAX12812.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAX14912.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAX14966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAX15055.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MALRD1 Gene

Proteomics data for MALRD1 Gene at MOPED

Post-translational modifications for MALRD1 Gene

No Post-translational modifications

Other Protein References for MALRD1 Gene

No data available for DME Specific Peptides for MALRD1 Gene

Domains & Families for MALRD1 Gene

Protein Domains for MALRD1 Gene

Suggested Antigen Peptide Sequences for MALRD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VYJ5

UniProtKB/Swiss-Prot:

MALR1_HUMAN :
  • Contains 8 LDL-receptor class A domains.
Domain:
  • Contains 8 LDL-receptor class A domains.
  • Contains 6 MAM domains.
genes like me logo Genes that share domains with MALRD1: view

No data available for Gene Families for MALRD1 Gene

Function for MALRD1 Gene

genes like me logo Genes that share phenotypes with MALRD1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MALRD1 Gene

Localization for MALRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MALRD1 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MALRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MALRD1: view

No data available for Subcellular locations from COMPARTMENTS for MALRD1 Gene

Pathways & Interactions for MALRD1 Gene

SuperPathways for MALRD1 Gene

No Data Available

Interacting Proteins for MALRD1 Gene

Gene Ontology (GO) - Biological Process for MALRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070858 negative regulation of bile acid biosynthetic process IEA --
genes like me logo Genes that share ontologies with MALRD1: view

No data available for Pathways by source and SIGNOR curated interactions for MALRD1 Gene

Drugs & Compounds for MALRD1 Gene

No Compound Related Data Available

Transcripts for MALRD1 Gene

mRNA/cDNA for MALRD1 Gene

(4) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MALRD1 Gene

No ASD Table

Relevant External Links for MALRD1 Gene

GeneLoc Exon Structure for
MALRD1
ECgene alternative splicing isoforms for
MALRD1

Expression for MALRD1 Gene

mRNA expression in normal human tissues for MALRD1 Gene

mRNA differential expression in normal tissues according to GTEx for MALRD1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x21.4).

Protein differential expression in normal tissues from HIPED for MALRD1 Gene

This gene is overexpressed in Cerebrospinal fluid (28.4), Fetal heart (16.6), Heart (13.2), and Pancreas (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MALRD1 Gene



genes like me logo Genes that share expression patterns with MALRD1: view

Protein tissue co-expression partners for MALRD1 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MALRD1 Gene

Orthologs for MALRD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MALRD1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia LOC102635496 35
  • 78.72 (n)
  • 72.93 (a)
Malrd1 16
rat
(Rattus norvegicus)
Mammalia LOC100361092 35
  • 78.06 (n)
  • 72.2 (a)
cow
(Bos Taurus)
Mammalia MALRD1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 18 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia MALRD1 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10ORF112 35
  • 65.33 (n)
  • 56.01 (a)
DIET1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MALRD1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496835 35
  • 61.33 (n)
  • 54.2 (a)
zebrafish
(Danio rerio)
Actinopterygii malrd1 35
  • 54.84 (n)
  • 47.92 (a)
DIET1 36
  • 45 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
ManyToMany
Species with no ortholog for MALRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MALRD1 Gene

ENSEMBL:
Gene Tree for MALRD1 (if available)
TreeFam:
Gene Tree for MALRD1 (if available)

Paralogs for MALRD1 Gene

Paralogs for MALRD1 Gene

(3) SIMAP similar genes for MALRD1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MALRD1: view

Variants for MALRD1 Gene

Sequence variations from dbSNP and Humsavar for MALRD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7100382 - 19,331,478(+) TACTG(A/C)TCATG reference, missense
rs7100403 - 19,331,510(+) ACTGC(A/G)TTGCC reference, missense
rs1609746 - 19,347,940(-) AAACT(A/C)TTTAT reference, missense
rs10827306 - 19,352,106(+) CACTG(A/C/T)AGAAC reference, missense
rs12773592 - 19,387,624(+) TACTG(A/G)TGAAA reference, missense

Variation tolerance for MALRD1 Gene

Gene Damage Index Score: 20.82; 99.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MALRD1 Gene

Disorders for MALRD1 Gene

Relevant External Links for MALRD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MALRD1

No disorders were found for MALRD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MALRD1 Gene

Publications for MALRD1 Gene

  1. Predicted gene sequence C10orf112 is transcribed, exhibits tissue-specific expression, and may correspond to AD7. (PMID: 19103277) Zubenko G.S. … Hughes H.B. (Genomics 2009) 2 3 67
  2. Diet1 is a regulator of fibroblast growth factor 15/19-dependent bile acid synthesis. (PMID: 26045262) Reue K. … Vergnes L. (Dig Dis 2015) 3
  3. Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. (PMID: 23747249) Vergnes L. … Reue K. (Cell Metab. 2013) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. D10S1423 identifies a susceptibility locus for Alzheimer's disease (AD7) in a prospective, longitudinal, double-blind study of asymptomatic individuals: results at 14 years. (PMID: 19591129) Zubenko G.S. … Zubenko W.N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3

Products for MALRD1 Gene

Sources for MALRD1 Gene

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