MALL Gene
protein-coding GIFtS: 55
GCID: GC02M110841
|
|
mal, T-cell differentiation protein-like
| |
Aliases
for MALL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mal, T-Cell Differentiation Protein-Like1 2 | | BENE1 2 3 5 | | MAL-Like Protein2 | | Protein BENE3 |
Export aliases for MALL gene to outside databasesPrevious GC identifers: GC02U990066 GC02M110199 GC02M103981 |
Summaries
for MALL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MALL:
This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein,a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM)rafts. It interacts with caveolin-1. (provided by RefSeq, Jul 2008)
Gene Wiki entry for MALL
|
Genomic Views
for MALL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MALL gene promoter:
TBP Pbx1a AP-1 LCR-F1 E47 PPAR-gamma1 HOXA5 TFIID Hand1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MALL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MALL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13MALL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M110841: view genomic region
(about GC identifiers)
Start:
|
110,841,447 bp from pter |
End:
|
110,874,143 bp from pter |
Size:
|
32,697 bases |
Orientation:
|
minus strand |
|
Proteins
for MALL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MALL_HUMAN, Q13021 (See
protein sequence)Recommended Name: MAL-like protein Size: 153 amino acids; 17350 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B3KWR6 Q9BTU0Explore the universe of human proteins at neXtProt for MALL: NX_Q13021
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13021
MALL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005425.1
ENSEMBL proteins: ENSP00000272462 ENSP00000400518 ENSP00000394792
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
MALL for ontologies About GeneDecksing
MALL Antibody Products:
Assay Products for MALL: |
Protein
Domains /
Families
for MALL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MALL for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13021ProtoNet protein and cluster: Q13021 1 Blocks protein family: IPB008253 Marvel
UniProtKB/Swiss-Prot: MALL_HUMAN, Q13021Similarity: Belongs to the MAL familySimilarity: Contains 1 MARVEL domain |
Function
for MALL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for MALL:T-cell differentiation proteolipid protein-like,6kb distal from NPHP1,MAL-like
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MALL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MALL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MALL (NM_005434) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MALL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MALL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MALL |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
MALL for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for MALL:
Animal Models:
1 MGI phenotypic allele  for Mall (no phenotypes)
MALL for phenotypes About GeneDecksing
|
Pathways & Interactions
for MALL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MALL
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for MALL (Q130212, 3 ENSP000002724624) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
MALL for ontologies About GeneDecksing
|
Drugs & Compounds
for MALL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MALL
Search CenterWatch for drugs/clinical trials and news about MALL
|
Transcripts
for MALL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MALL gene: NM_005434.4 Unigene Cluster for MALL: Mal, T-cell differentiation protein-like Hs.185055 [show with all ESTs]Unigene Representative Sequence: NM_0054343 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000272462(uc002tfk.3 uc010fju.3) ENST00000427178 ENST00000424988
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MALL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MALL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MALL (NM_005434) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MALL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MALL |
Additional cDNA sequence: AK056616.1 AK125647.1 AK311353.1 BC003179.1 U17077.1 11 DOTS entries: DT.95200360 DT.95161703 DT.100812709 DT.100025724 DT.91697814 DT.95161697 DT.97841839 DT.100038233 DT.121031921 DT.91662998 DT.95336173 24/155 AceView cDNA sequences (see all 155): BM837191 AW954873 BE336699 AU280479 BM926266 CB128672 AL047001 AI672956 BQ881097 AU141140 CN483792 AU141593 CA393120 BM967021 BM686997 BP382561 BE906870 BG324877 BM999672 CA443569 BU727471 AI991179 AI167941 BI818651
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MALL (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MALL
|
Expression
for MALL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MALL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAATAAAAG
About this image
See MALL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MALL
SOURCE GeneReport for Unigene cluster: Hs.185055
SABiosciences Custom PCR Arrays for MALL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MALL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MALL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MALL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MALL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MALL |
Orthologs
for MALL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MALL gene from 2/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MALL1 |
mal, T-cell differentiation protein-like |
65.56(n)
64.24(a) |
|
421222 NM_001199428.1 NP_001186357.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MALL6 |
-- |
63(a) |
1 ↔ 1 |
GL343727.1(150046-169581) |
ENSEMBL Gene Tree for MALL (if available)
TreeFam Gene Tree for MALL (if available) |
Paralogs
for MALL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MALL gene
- MAL2 PLLP2 CMTM82
4 SIMAP similar genes for MALL using alignment to 3 protein entries: MALL_HUMAN (see all proteins):MAL CMTM8 MAL2 PLLP
MALL for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for MALL
PGOHUM00000240141 PGOHUM00000240784 PGOHUM00000240854 PGOHUM00000257215
|
Genomic Variants
for MALL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MALL (110841447 - 110874143 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 19 variations for MALL
15/18 CNVs (see all 18): 8383 50251 53344 2404 50253 97936 50256 53943 34511 53565 50254 8954 9960 48026 50255
1 Inversion: 37209
Human Gene Mutation Database (HGMD): MALL
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MALL |
|
Disorders
/ Diseases
for MALL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MALL for disorders About GeneDecksing
OMIM gene information: 602022
OMIM disorders: --
10  diseases for MALL: About MalaCardsoccupational dermatitis cholesterol alcoholic neuropathy nephronophthisis
skin melanoma alcoholism dermatitis neuropathy
melanoma adenoma
Human Genome Epidemiology (HuGE) Navigator: MALL (34 documents)
Export disorders for MALL gene to outside databases
|
Publications
for MALL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MALL gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MALL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1. (PubMed id 9326933)1, 3 Hildebrandt F.... Brandis M. (1997)
- Searching for non-V kappa transcripts from the human immunoglobulin kappa locus. (PubMed id 7622049)1, 2 Lautner-Rieske A.... Zachau H.G. (1995)
- A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis. (PubMed id 9361039)1, 9 Saunier S.... Antignac C. (1997)
- Gene profiling of colonic serrated adenomas by using oligonucleotide microarray. (PubMed id 18305945)1 Kim K....Park J. (2008)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells. (PubMed id 11294831)1 de Marco M.C....Alonso M.A. (2001)
|
External Searches for MALL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MALL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MALL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MALL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MALL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MALL gene:
Search GeneIP for patents involving MALL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MALL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MALL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MALL | | | OriGene Protein Over-expression Lysate for MALL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MALL | | OriGene 3'-UTR Clone for MALL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MALL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MALL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MALL | | OriGene Custom Protein Services for MALL | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MALL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MALL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MALL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MALL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MALL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MALL |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MALL |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MALL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MALL |
|  |  |  | | | | ThermoFisher Antibodies for MALL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MALL |
|
|
|
|
