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Aliases for MALL Gene

Aliases for MALL Gene

  • Mal, T-Cell Differentiation Protein-Like 2 3
  • BENE 3 4 6
  • MAL-Like Protein 3
  • Protein BENE 4

External Ids for MALL Gene

Previous GeneCards Identifiers for MALL Gene

  • GC02U990066
  • GC02M110199
  • GC02M110841
  • GC02M103981

Summaries for MALL Gene

Entrez Gene Summary for MALL Gene

  • This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts. It interacts with caveolin-1. [provided by RefSeq, Jul 2008]

GeneCards Summary for MALL Gene

MALL (Mal, T-Cell Differentiation Protein-Like) is a Protein Coding gene. Diseases associated with MALL include skin melanoma and juvenile nephronophthisis. An important paralog of this gene is MAL.

Gene Wiki entry for MALL Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MALL Gene

Genomics for MALL Gene

Regulatory Elements for MALL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MALL Gene

110,083,870 bp from pter
110,116,566 bp from pter
32,697 bases
Minus strand

Genomic View for MALL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MALL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MALL Gene

Proteins for MALL Gene

  • Protein details for MALL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MAL-like protein
    Protein Accession:
    Secondary Accessions:
    • B3KWR6
    • Q9BTU0

    Protein attributes for MALL Gene

    153 amino acids
    Molecular mass:
    17350 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MALL Gene

Proteomics data for MALL Gene at MOPED

Post-translational modifications for MALL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MALL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MALL Gene

Domains for MALL Gene

Protein Domains for MALL Gene


Suggested Antigen Peptide Sequences for MALL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MARVEL domain.
  • Belongs to the MAL family.
  • Contains 1 MARVEL domain.
  • Belongs to the MAL family.
genes like me logo Genes that share domains with MALL: view

No data available for Gene Families for MALL Gene

Function for MALL Gene

Molecular function for MALL Gene

GENATLAS Biochemistry:
T-cell differentiation proteolipid protein-like,6kb distal from NPHP1,MAL-like

Gene Ontology (GO) - Molecular Function for MALL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11294831
genes like me logo Genes that share ontologies with MALL: view
genes like me logo Genes that share phenotypes with MALL: view

Animal Model Products

miRNA for MALL Gene

miRTarBase miRNAs that target MALL

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MALL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MALL Gene

Localization for MALL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MALL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MALL Gene COMPARTMENTS Subcellular localization image for MALL gene
Compartment Confidence
golgi apparatus 4
plasma membrane 4
lysosome 1

Gene Ontology (GO) - Cellular Components for MALL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 11294831
GO:0005886 plasma membrane IDA 11294831
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle IDA 11294831
genes like me logo Genes that share ontologies with MALL: view

Pathways for MALL Gene

SuperPathways for MALL Gene

No Data Available

Gene Ontology (GO) - Biological Process for MALL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042632 cholesterol homeostasis NAS 11294831
genes like me logo Genes that share ontologies with MALL: view

No data available for Pathways by source for MALL Gene

Transcripts for MALL Gene

mRNA/cDNA for MALL Gene

Unigene Clusters for MALL Gene

Mal, T-cell differentiation protein-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MALL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MALL Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: - - - - - -
SP3: - -
SP4: - -
SP6: - - - - -

Relevant External Links for MALL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MALL Gene

mRNA expression in normal human tissues for MALL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MALL Gene

This gene is overexpressed in Esophagus - Mucosa (16.4), Vagina (5.4), and Colon - Transverse (4.4).

SOURCE GeneReport for Unigene cluster for MALL Gene Hs.185055

genes like me logo Genes that share expressions with MALL: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MALL Gene

Orthologs for MALL Gene

This gene was present in the common ancestor of chordates.

Orthologs for MALL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MALL 35
  • 83.77 (n)
  • 82.89 (a)
  • 83 (a)
(Canis familiaris)
Mammalia MALL 35
  • 84.87 (n)
  • 82.24 (a)
  • 78 (a)
(Mus musculus)
Mammalia Mall 35
  • 83.55 (n)
  • 85.53 (a)
Mall 16
Mall 36
  • 82 (a)
(Pan troglodytes)
Mammalia MALL 35
  • 99.35 (n)
  • 99.35 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Mall 35
  • 83.77 (n)
  • 83.55 (a)
(Monodelphis domestica)
Mammalia MALL 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MALL 36
  • 67 (a)
(Gallus gallus)
Aves MALL 35
  • 65.57 (n)
  • 63.82 (a)
  • 61 (a)
(Anolis carolinensis)
Reptilia MALL 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mall 35
  • 53.94 (n)
  • 44.44 (a)
Species with no ortholog for MALL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MALL Gene

Gene Tree for MALL (if available)
Gene Tree for MALL (if available)

Paralogs for MALL Gene

Paralogs for MALL Gene

(4) SIMAP similar genes for MALL Gene using alignment to 3 proteins: Pseudogenes for MALL Gene

genes like me logo Genes that share paralogs with MALL: view

Variants for MALL Gene

Sequence variations from dbSNP and Humsavar for MALL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs163649 -- 110,083,530(+) GAGCC(A/G)TGCGG downstream-variant-500B
rs163669 -- 110,093,063(+) GCTAT(A/G)TTTAG intron-variant
rs163670 -- 110,093,006(+) tgaaa(A/G)gtcag intron-variant
rs163671 -- 110,092,890(+) ACGTC(C/T)TTAAA intron-variant
rs737181 -- 110,105,843(-) GGGAG(A/C)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MALL Gene

Variant ID Type Subtype PubMed ID
nsv510884 CNV Complex 20534489
esv2751812 CNV Loss 17911159
dgv4263n71 CNV Gain 21882294
nsv7324 OTHER Inversion 18451855
nsv874792 CNV Gain 21882294
nsv499578 OTHER Inversion 21111241
nsv834329 CNV Gain 17160897
nsv874799 CNV Gain 21882294
esv2556499 CNV Gain 19546169
nsv458751 CNV Loss 19166990
dgv471n27 CNV Gain 19166990
dgv472n27 CNV Loss 19166990
nsv470479 CNV Gain 18288195
nsv515996 CNV Gain+Loss 19592680
nsv818076 CNV Loss 17921354
dgv4268n71 CNV Gain 21882294
dgv154e55 CNV Loss 17911159
dgv155e55 CNV Gain 17911159
essv3631 CNV CNV 17122850
nsv874809 CNV Gain+Loss 21882294
esv33999 CNV Loss 18971310
dgv473n27 CNV Gain 19166990
nsv874813 CNV Gain 21882294
nsv874814 CNV Gain 21882294
nsv2875 CNV Loss 18451855
nsv874820 CNV Gain 21882294

Relevant External Links for MALL Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MALL Gene

Disorders for MALL Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MALL Gene in MalaCards »

(3) Diseases for MALL Gene

Relevant External Links for MALL

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MALL: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MALL Gene

Publications for MALL Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1. (PMID: 9326933) Hildebrandt F. … Brandis M. (Nat. Genet. 1997) 2 3
  4. Searching for non-V kappa transcripts from the human immunoglobulin kappa locus. (PMID: 7622049) Lautner-Rieske A. … Zachau H.G. (Gene 1995) 3 4
  5. A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis. (PMID: 9361039) Saunier S. … Antignac C. (Hum. Mol. Genet. 1997) 3 23

Products for MALL Gene

Sources for MALL Gene

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