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Aliases for MALL Gene

Aliases for MALL Gene

  • Mal, T-Cell Differentiation Protein-Like 2 3
  • BENE 3 4
  • Protein BENE 4

External Ids for MALL Gene

Previous GeneCards Identifiers for MALL Gene

  • GC02U990066
  • GC02M110199
  • GC02M110841
  • GC02M103981

Summaries for MALL Gene

Entrez Gene Summary for MALL Gene

  • This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts. It interacts with caveolin-1. [provided by RefSeq, Jul 2008]

GeneCards Summary for MALL Gene

MALL (Mal, T-Cell Differentiation Protein-Like) is a Protein Coding gene. Diseases associated with MALL include maxillary sinus cancer and paranasal sinus cancer. An important paralog of this gene is MAL.

Gene Wiki entry for MALL Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MALL Gene

Genomics for MALL Gene

Regulatory Elements for MALL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MALL Gene

Chromosome:
2
Start:
110,083,870 bp from pter
End:
110,118,139 bp from pter
Size:
34,270 bases
Orientation:
Minus strand

Genomic View for MALL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MALL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MALL Gene

Proteins for MALL Gene

  • Protein details for MALL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13021-MALL_HUMAN
    Recommended name:
    MAL-like protein
    Protein Accession:
    Q13021
    Secondary Accessions:
    • B3KWR6
    • Q9BTU0

    Protein attributes for MALL Gene

    Size:
    153 amino acids
    Molecular mass:
    17350 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MALL Gene

Proteomics data for MALL Gene at MOPED

Post-translational modifications for MALL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MALL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MALL Gene

Domains & Families for MALL Gene

Protein Domains for MALL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MALL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13021

UniProtKB/Swiss-Prot:

MALL_HUMAN :
  • Contains 1 MARVEL domain.
  • Belongs to the MAL family.
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the MAL family.
genes like me logo Genes that share domains with MALL: view

No data available for Gene Families for MALL Gene

Function for MALL Gene

Molecular function for MALL Gene

GENATLAS Biochemistry:
T-cell differentiation proteolipid protein-like,6kb distal from NPHP1,MAL-like

Gene Ontology (GO) - Molecular Function for MALL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11294831
genes like me logo Genes that share ontologies with MALL: view
genes like me logo Genes that share phenotypes with MALL: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MALL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MALL Gene

Localization for MALL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MALL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MALL Gene COMPARTMENTS Subcellular localization image for MALL gene
Compartment Confidence
golgi apparatus 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for MALL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 11294831
GO:0005886 plasma membrane IDA 11294831
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle IDA 11294831
genes like me logo Genes that share ontologies with MALL: view

Pathways & Interactions for MALL Gene

SuperPathways for MALL Gene

No Data Available

Gene Ontology (GO) - Biological Process for MALL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042632 cholesterol homeostasis NAS 11294831
genes like me logo Genes that share ontologies with MALL: view

No data available for Pathways by source and SIGNOR curated interactions for MALL Gene

Drugs & Compounds for MALL Gene

No Compound Related Data Available

Transcripts for MALL Gene

Unigene Clusters for MALL Gene

Mal, T-cell differentiation protein-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MALL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MALL Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: -
SP2: - - - - - -
SP3: - -
SP4: - -
SP5:
SP6: - - - - -

Relevant External Links for MALL Gene

GeneLoc Exon Structure for
MALL
ECgene alternative splicing isoforms for
MALL

Expression for MALL Gene

mRNA expression in normal human tissues for MALL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MALL Gene

This gene is overexpressed in Esophagus - Mucosa (x16.4), Vagina (x5.4), and Colon - Transverse (x4.4).

SOURCE GeneReport for Unigene cluster for MALL Gene Hs.185055

genes like me logo Genes that share expression patterns with MALL: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MALL Gene

Orthologs for MALL Gene

This gene was present in the common ancestor of chordates.

Orthologs for MALL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MALL 35
  • 83.77 (n)
  • 82.89 (a)
MALL 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MALL 35
  • 84.87 (n)
  • 82.24 (a)
MALL 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mall 35
  • 83.55 (n)
  • 85.53 (a)
Mall 16
Mall 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MALL 35
  • 99.35 (n)
  • 99.35 (a)
MALL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mall 35
  • 83.77 (n)
  • 83.55 (a)
oppossum
(Monodelphis domestica)
Mammalia MALL 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MALL 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves MALL 35
  • 65.57 (n)
  • 63.82 (a)
MALL 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MALL 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mall 35
  • 53.94 (n)
  • 44.44 (a)
Species with no ortholog for MALL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MALL Gene

ENSEMBL:
Gene Tree for MALL (if available)
TreeFam:
Gene Tree for MALL (if available)

Paralogs for MALL Gene

Paralogs for MALL Gene

(4) SIMAP similar genes for MALL Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MALL Gene

genes like me logo Genes that share paralogs with MALL: view

Variants for MALL Gene

Sequence variations from dbSNP and Humsavar for MALL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2983 -- 110,085,531(-) CACAC(C/T)TTGTT utr-variant-3-prime
rs10389 -- 110,084,261(-) CTGTG(C/T)TCTTC utr-variant-3-prime
rs163638 -- 110,088,970(-) cccca(A/G)ctgct intron-variant
rs163639 -- 110,088,804(-) atcgt(A/C)ccctt intron-variant
rs163644 -- 110,085,127(+) gggca(C/T)ggtgg utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MALL Gene

Variant ID Type Subtype PubMed ID
nsv510884 CNV Complex 20534489
esv2751812 CNV Loss 17911159
dgv4263n71 CNV Gain 21882294
nsv7324 OTHER Inversion 18451855
nsv874792 CNV Gain 21882294
nsv499578 OTHER Inversion 21111241
nsv834329 CNV Gain 17160897
nsv874799 CNV Gain 21882294
esv2556499 CNV Gain 19546169
nsv458751 CNV Loss 19166990
dgv471n27 CNV Gain 19166990
dgv472n27 CNV Loss 19166990
nsv470479 CNV Gain 18288195
nsv515996 CNV Gain+Loss 19592680
nsv818076 CNV Loss 17921354
dgv4268n71 CNV Gain 21882294
dgv154e55 CNV Loss 17911159
dgv155e55 CNV Gain 17911159
essv3631 CNV CNV 17122850
nsv874809 CNV Gain+Loss 21882294
esv33999 CNV Loss 18971310
dgv473n27 CNV Gain 19166990
nsv874813 CNV Gain 21882294
nsv874814 CNV Gain 21882294
nsv2875 CNV Loss 18451855
nsv874820 CNV Gain 21882294

Variation tolerance for MALL Gene

Gene Damage Index Score: 0.12; 2.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MALL Gene

HapMap Linkage Disequilibrium report
MALL
Human Gene Mutation Database (HGMD)
MALL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MALL Gene

Disorders for MALL Gene

MalaCards: The human disease database

(3) MalaCards diseases for MALL Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
maxillary sinus cancer
  • malignant neoplasm of antrum
paranasal sinus cancer
  • adenoid cystic carcinoma of accessory sinus
nephronophthisis
  • medullary cystic kidney disease 1
- elite association
Search MALL in MalaCards View complete list of genes associated with diseases

Relevant External Links for MALL

Human Genome Epidemiology (HuGE) Navigator
MALL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MALL
genes like me logo Genes that share disorders with MALL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MALL Gene

Publications for MALL Gene

  1. A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis. (PMID: 9361039) Saunier S. … Antignac C. (Hum. Mol. Genet. 1997) 23 67
  2. A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1. (PMID: 9326933) Hildebrandt F. … Brandis M. (Nat. Genet. 1997) 2 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation. (PMID: 25496667) Landi A. … Verhasselt B. (Retrovirology 2014) 67
  5. Gene profiling of colonic serrated adenomas by using oligonucleotide microarray. (PMID: 18305945) Kim K. … Park J. (Int J Colorectal Dis 2008) 67

Products for MALL Gene

Sources for MALL Gene

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