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MALAT1 Gene

RNA gene   GIFtS: 31

GC11P065032
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
HCN 1, 2
MALAT-1 1, 2
NCRNA00047 1, 2
NEAT2 2
PRO1073 1, 5
PRO2853 2
Descriptions
metastasis associated lung adenocarcinoma transcript 1
(non-protein coding) 2
External Ids
HGNC: 296651
Entrez Gene: 3789382
UniProtKB: Q9UHZ23
Search outside databases for aliases for MALAT1 gene

Previous GC identifer: GC11U900628

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MALAT1 gene  

Entrez Gene cytogenetic band: 11q13.1   HGNC cytogenetic band: 11q13.1

MALAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P065032:     (about GC identifiers)

Start:
65,022,410 bp from pter
End:
65,030,999 bp from pter
Size:
8,590 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000011.8  NT_033903.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MALAT_HUMAN, Q9UHZ2 (See protein sequence)
Recommended Name: Metastasis-associated lung adenocarcinoma transcript 1  
Size: 57 amino acids; 6289 Da


Human Recombinant Proteins 

Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
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Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for MALAT1: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for MALAT1

Assays for MALAT1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9UHZ2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for MALAT1

              Browse siRNA at Sigma-Aldrich  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                Browse Origene for untagged/tagged cDNA clones in CMV expression vector

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NR_002819

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MALAT1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Browse siRNA at Sigma-Aldrich  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  


                Browse Origene for untagged/tagged cDNA clones in CMV expression vector

Additional cDNA sequence: 

AJ535464.1 AJ535465.1 AJ535466.1 

24/330 DOTS entries (see all 330 ):

DT.91900579  DT.95351792  DT.91927045  DT.100735204  DT.100735190  DT.95377975  DT.91955986  DT.100061127 
DT.91925908  DT.100735117  DT.100735200  DT.100735119  DT.95378317  DT.95291680  DT.99982642  DT.91905728 
DT.97869937  DT.100735207  DT.100735188  DT.98083654  DT.95378105  DT.92357998  DT.100060487  DT.92407302 

2 RNAdb entries of non coding RNAs:

LIT2013    LIT2012   

highest scoring ESTs for MALAT1:

AA044613 AA064973 AA135532 AA135552 AA308234 AA319118 AA329765 AA373984 AA463254 AA578446 

Unigene Clusters for MALAT1:

Metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
Hs.642877  [show with all ESTs], Hs.714394  [show with all ESTs]
Unigene Representative Sequences: EF177381, BF675113


GeneLoc Exon Structure

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MALAT1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for MALAT1

1 / 2 / 3

24 probe-sets matching MALAT1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
58491_s_at2, 3 U95-B 1 1.00 1.00 0.97 0.98 N78139 0.60 1.00 0.82 1

91068_at2, 3 U95-E 1 1.00 1.00 0.93 1.43 AI557412 0.60 1.00 0.82 1
43818_at2, 3 U95-B 1 1.00 1.00 0.97 1.06 AW007987 0.60 1.00 0.82 1

67835_at2, 3 U95-D 1 1.00 1.00 -0.18 0.33 AI478918 0.20 0.50 0.38 1

49671_at2, 3 U95-C 1 1.00 1.00 0.86 1.42 AL037363 0.60 0.61 0.61 1
58494_r_at2, 3 U95-B 1 1.00 1.00 0.91 0.81 N78139 0.60 1.00 0.82 1

43819_g_at2, 3 U95-B 1 1.00 1.00 0.95 1.30 AW007987 0.60 1.00 0.82 1
78200_at2, 3 U95-E 1 0.69 1.00 0.13 0.79 AI248811 0.60 0.67 0.63 1

80675_at2, 3 U95-E 3 0.38 0.43 0.14 0.91 AI990026 0.20 0.17 0.18 2

224559_at2, 3 U133-B 1 1.00 1.00 -- -- AF001540 0.40 1.00 0.76 1

223940_x_at2, 3 U133-B 1 1.00 1.00 -- -- AF132202 0.20 1.00 0.72 1

226675_s_at2, 3 U133-B 1 1.00 1.00 -- -- W80468 0.40 0.75 0.60 1

224568_x_at2, 3 U133-B 1 1.00 1.00 -- -- AW005982 0.40 0.75 0.60 1

224558_s_at2, 3 U133-B 1 1.00 1.00 -- -- AI446756 0.60 0.83 0.73 1

224567_x_at2, 3 U133-B 2 1.00 0.73 -- -- BG534952 0.40 0.75 0.60 1

231735_s_at*2, 3 U133-B NULL 0.00 0.00 -- -- NM_014086 0.20 1.00 0.72 1

224559_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

223940_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1558678_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

226675_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

224568_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

224558_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

224567_x_at2 U133Plus2 2 1.00 0.73 -- -- -- -- -- -- --

231735_s_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
GeneDecks  MALAT1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ACGCAGGGAG

SOURCE GeneReport for Unigene clusters: Hs.642877 Hs.714394
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for MALAT1 gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
mouse
(Mus musculus)
Malat15 19 metastasis associated lung adenocarcinoma transcript more   -- EF177380 
About this table        Species with no ortholog for MALAT1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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  --
(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 607924

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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9 PubMed articles for MALAT1 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 378938 HGNC: 29665 euGenes: HUgn378938 ECgene: MALAT1 H-InvDB: MALAT1
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for MALAT1 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for MALAT1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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