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Aliases for MAL2 Gene

Aliases for MAL2 Gene

  • Mal, T Cell Differentiation Protein 2 (Gene/Pseudogene) 2 3
  • Mal, T-Cell Differentiation Protein 2 (Gene/Pseudogene) 2 5
  • MAL Proteolipid Protein 2 2

External Ids for MAL2 Gene

Previous GeneCards Identifiers for MAL2 Gene

  • GC08P120226
  • GC08P119889
  • GC08P120177
  • GC08P120289
  • GC08P115541

Summaries for MAL2 Gene

Entrez Gene Summary for MAL2 Gene

  • This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAL2 Gene

MAL2 (Mal, T Cell Differentiation Protein 2 (Gene/Pseudogene)) is a Protein Coding gene. An important paralog of this gene is MAL.

UniProtKB/Swiss-Prot for MAL2 Gene

  • Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.

Gene Wiki entry for MAL2 Gene

Additional gene information for MAL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAL2 Gene

Genomics for MAL2 Gene

GeneHancer (GH) Regulatory Elements for MAL2 Gene

Promoters and enhancers for MAL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I119203 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 561.4 +41.6 41644 7 PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ETS1 YY1 MAL2 NOV DSCC1 MAL2-AS1 LOC105375725
GH08I119226 Enhancer 0.7 ENCODE 29.5 +61.8 61750 0.6 SOX13 TFAP4 FOXA2 SIN3A ZNF384 TEAD3 GATA3 MAFK GATAD2A RFX1 MAL2 MAL2-AS1
GH08I119222 Enhancer 0.7 ENCODE dbSUPER 13.6 +58.2 58182 0.6 GATA3 ZNF512B TARDBP NEUROD1 DPF2 ELF1 CUX1 MAL2 NOV MAL2-AS1
GH08I119176 Enhancer 0.8 ENCODE 11.8 +12.7 12744 3.1 MXI1 JUN MAX CEBPG RAD21 ZBTB40 RFX5 GTF3C2 CTBP1 GATA3 TAF2 MAL2 LOC105375725 MAL2-AS1
GH08I119200 Enhancer 1 ENCODE dbSUPER 7.7 +35.9 35877 0.8 HDGF PKNOX1 NFIB NEUROD1 SIN3A RAD21 RFX5 SMARCC2 FOS RCOR1 MAL2 MAL2-AS1 LOC105375725
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAL2 gene promoter:

Genomic Locations for MAL2 Gene

Genomic Locations for MAL2 Gene
80,640 bases
Plus strand

Genomic View for MAL2 Gene

Genes around MAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAL2 Gene

Proteins for MAL2 Gene

  • Protein details for MAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein MAL2
    Protein Accession:
    Secondary Accessions:
    • B2R520
    • Q6ZMD9

    Protein attributes for MAL2 Gene

    176 amino acids
    Molecular mass:
    19125 Da
    Quaternary structure:
    • Interacts with TPD52L2.
    • Sequence=BAD18789.1; Type=Frameshift; Positions=166; Evidence={ECO:0000305};

neXtProt entry for MAL2 Gene

Post-translational modifications for MAL2 Gene

Other Protein References for MAL2 Gene

No data available for DME Specific Peptides for MAL2 Gene

Domains & Families for MAL2 Gene

Gene Families for MAL2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MAL2 Gene


Suggested Antigen Peptide Sequences for MAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MAL family.
  • Belongs to the MAL family.
genes like me logo Genes that share domains with MAL2: view

Function for MAL2 Gene

Molecular function for MAL2 Gene

UniProtKB/Swiss-Prot Function:
Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.

Phenotypes From GWAS Catalog for MAL2 Gene

Gene Ontology (GO) - Molecular Function for MAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12963375
GO:0019911 structural constituent of myelin sheath IBA --
genes like me logo Genes that share ontologies with MAL2: view
genes like me logo Genes that share phenotypes with MAL2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAL2 Gene

Localization for MAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAL2 Gene

Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endomembrane system. Cytoplasm, perinuclear region. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized Hep-G2 cells, distributed to the perinuclear region.

Gene Ontology (GO) - Cellular Components for MAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with MAL2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MAL2 Gene

Pathways & Interactions for MAL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001766 membrane raft polarization IBA --
GO:0008104 protein localization IBA --
GO:0042552 myelination IBA --
GO:0045056 transcytosis IEA --
genes like me logo Genes that share ontologies with MAL2: view

No data available for Pathways by source and SIGNOR curated interactions for MAL2 Gene

Drugs & Compounds for MAL2 Gene

No Compound Related Data Available

Transcripts for MAL2 Gene

Unigene Clusters for MAL2 Gene

Mal, T-cell differentiation protein 2 (gene/pseudogene):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAL2 Gene

No ASD Table

Relevant External Links for MAL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAL2 Gene

This gene is overexpressed in Esophagus - Mucosa (x12.7) and Vagina (x4.1).

Protein differential expression in normal tissues from HIPED for MAL2 Gene

This gene is overexpressed in Nasal epithelium (43.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAL2 Gene:


SOURCE GeneReport for Unigene cluster for MAL2 Gene:


mRNA Expression by UniProt/SwissProt for MAL2 Gene:

Tissue specificity: Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine.
genes like me logo Genes that share expression patterns with MAL2: view

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAL2 Gene

Orthologs for MAL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAL2 33
  • 99.24 (n)
(Canis familiaris)
Mammalia MAL2 33 34
  • 89.8 (n)
(Mus musculus)
Mammalia Mal2 33 16 34
  • 88.38 (n)
(Monodelphis domestica)
Mammalia MAL2 34
  • 88 (a)
(Bos Taurus)
Mammalia MAL2 33 34
  • 87.69 (n)
(Rattus norvegicus)
Mammalia Mal2 33
  • 87.12 (n)
(Gallus gallus)
Aves MAL2 33 34
  • 68.58 (n)
(Anolis carolinensis)
Reptilia MAL2 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mal2 33
  • 65.47 (n)
(Danio rerio)
Actinopterygii zgc:195265 33
  • 58.19 (n)
MAL2 (2 of 2) 34
  • 52 (a)
MAL2 (1 of 2) 34
  • 51 (a)
Species where no ortholog for MAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAL2 Gene

Gene Tree for MAL2 (if available)
Gene Tree for MAL2 (if available)

Paralogs for MAL2 Gene

Paralogs for MAL2 Gene

(2) SIMAP similar genes for MAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAL2: view

Variants for MAL2 Gene

Sequence variations from dbSNP and Humsavar for MAL2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000032168 -- 119,216,636(+) C/T intron_variant
rs1000064212 -- 119,235,610(+) C/G intron_variant
rs1000087977 -- 119,226,506(+) G/A intron_variant
rs1000106701 -- 119,216,416(+) C/T intron_variant
rs1000139935 -- 119,222,834(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAL2 Gene

Variant ID Type Subtype PubMed ID
esv2759639 CNV gain 17122850

Variation tolerance for MAL2 Gene

Gene Damage Index Score: 5.78; 73.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAL2 Gene

Disorders for MAL2 Gene

Additional Disease Information for MAL2

No disorders were found for MAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAL2 Gene

Publications for MAL2 Gene

  1. Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system. (PMID: 11549320) Wilson SH … Byrne JA (Genomics 2001) 2 3 4 22 58
  2. Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells. (PMID: 14576188) Marazuela M … Alonso MA (Endocrinology 2004) 3 4 22 58
  3. Characterization of the MAL2-positive compartment in oligodendrocytes. (PMID: 19683524) Bello-Morales R … López-Guerrero JA (Experimental cell research 2009) 3 22 58
  4. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PMID: 19668339) Potkin SG … Alzheimer's Disease Neuroimaging Initiative (PloS one 2009) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for MAL2 Gene

Sources for MAL2 Gene

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