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Aliases for MAL2 Gene

Aliases for MAL2 Gene

  • Mal, T-Cell Differentiation Protein 2 (Gene/Pseudogene) 2 3 5
  • MAL Proteolipid Protein 2 2

External Ids for MAL2 Gene

Previous GeneCards Identifiers for MAL2 Gene

  • GC08P120226
  • GC08P119889
  • GC08P120177
  • GC08P120289
  • GC08P115541

Summaries for MAL2 Gene

Entrez Gene Summary for MAL2 Gene

  • This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAL2 Gene

MAL2 (Mal, T-Cell Differentiation Protein 2 (Gene/Pseudogene)) is a Protein Coding gene. An important paralog of this gene is MALL.

UniProtKB/Swiss-Prot for MAL2 Gene

  • Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.

Gene Wiki entry for MAL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAL2 Gene

Genomics for MAL2 Gene

Regulatory Elements for MAL2 Gene

Enhancers for MAL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAL2 Gene

119,165,034 bp from pter
119,245,673 bp from pter
80,640 bases
Plus strand

Genomic View for MAL2 Gene

Genes around MAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAL2 Gene

Proteins for MAL2 Gene

  • Protein details for MAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein MAL2
    Protein Accession:
    Secondary Accessions:
    • B2R520
    • Q6ZMD9

    Protein attributes for MAL2 Gene

    176 amino acids
    Molecular mass:
    19125 Da
    Quaternary structure:
    • Interacts with TPD52L2.
    • Sequence=BAD18789.1; Type=Frameshift; Positions=166; Evidence={ECO:0000305};

neXtProt entry for MAL2 Gene

Proteomics data for MAL2 Gene at MOPED

Post-translational modifications for MAL2 Gene

  • Glycosylation at Asn 132
  • Modification sites at PhosphoSitePlus

Other Protein References for MAL2 Gene

No data available for DME Specific Peptides for MAL2 Gene

Domains & Families for MAL2 Gene

Protein Domains for MAL2 Gene


Suggested Antigen Peptide Sequences for MAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MARVEL domain.
  • Belongs to the MAL family.
  • Contains 1 MARVEL domain.
  • Belongs to the MAL family.
genes like me logo Genes that share domains with MAL2: view

No data available for Gene Families for MAL2 Gene

Function for MAL2 Gene

Molecular function for MAL2 Gene

UniProtKB/Swiss-Prot Function:
Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
genes like me logo Genes that share phenotypes with MAL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MAL2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAL2 Gene

Localization for MAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAL2 Gene

Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endomembrane system. Cytoplasm, perinuclear region. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized Hep-G2 cells, distributed to the perinuclear region.

Gene Ontology (GO) - Cellular Components for MAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0045121 membrane raft IDA 23264465
GO:0048471 perinuclear region of cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MAL2: view

No data available for Subcellular locations from COMPARTMENTS for MAL2 Gene

Pathways & Interactions for MAL2 Gene

SuperPathways for MAL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAL2 Gene

Drugs & Compounds for MAL2 Gene

No Compound Related Data Available

Transcripts for MAL2 Gene

Unigene Clusters for MAL2 Gene

Mal, T-cell differentiation protein 2 (gene/pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAL2 Gene

No ASD Table

Relevant External Links for MAL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAL2 Gene

mRNA expression in normal human tissues for MAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAL2 Gene

This gene is overexpressed in Esophagus - Mucosa (x12.7) and Vagina (x4.1).

Protein differential expression in normal tissues from HIPED for MAL2 Gene

This gene is overexpressed in Nasal epithelium (43.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MAL2 Gene

SOURCE GeneReport for Unigene cluster for MAL2 Gene Hs.201083

mRNA Expression by UniProt/SwissProt for MAL2 Gene

Tissue specificity: Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine.
genes like me logo Genes that share expression patterns with MAL2: view

Primer Products

No data available for Protein tissue co-expression partners for MAL2 Gene

Orthologs for MAL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAL2 35
  • 87.69 (n)
  • 90.34 (a)
MAL2 36
  • 90 (a)
(Canis familiaris)
Mammalia MAL2 35
  • 89.8 (n)
  • 91.79 (a)
MAL2 36
  • 92 (a)
(Mus musculus)
Mammalia Mal2 35
  • 88.38 (n)
  • 92 (a)
Mal2 16
Mal2 36
  • 89 (a)
(Pan troglodytes)
Mammalia MAL2 35
  • 99.24 (n)
  • 98.86 (a)
(Rattus norvegicus)
Mammalia Mal2 35
  • 87.12 (n)
  • 90.34 (a)
(Monodelphis domestica)
Mammalia MAL2 36
  • 88 (a)
(Gallus gallus)
Aves MAL2 35
  • 68.58 (n)
  • 66.67 (a)
MAL2 36
  • 64 (a)
(Anolis carolinensis)
Reptilia MAL2 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mal2 35
  • 65.47 (n)
  • 62.87 (a)
(Danio rerio)
Actinopterygii zgc:195265 35
  • 58.19 (n)
  • 56.8 (a)
MAL2 (1 of 2) 36
  • 51 (a)
MAL2 (2 of 2) 36
  • 52 (a)
Species with no ortholog for MAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAL2 Gene

Gene Tree for MAL2 (if available)
Gene Tree for MAL2 (if available)

Paralogs for MAL2 Gene

Paralogs for MAL2 Gene

(2) SIMAP similar genes for MAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAL2: view

Variants for MAL2 Gene

Sequence variations from dbSNP and Humsavar for MAL2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_050016 -
rs3083446 -- 119,211,715(+) TTTTT(-/TTT)GAGAT intron-variant
rs3739420 -- 119,208,356(-) CCGCG(A/C)GGGAG upstream-variant-2KB
rs3812491 -- 119,206,890(-) TTAGT(A/G)AGTGA upstream-variant-2KB
rs3841191 -- 119,206,996(-) TTTAT(-/TTTCT)GCCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAL2 Gene

Variant ID Type Subtype PubMed ID
essv5532 CNV CNV 17122850

Variation tolerance for MAL2 Gene

Gene Damage Index Score: 5.78; 73.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAL2 Gene

Disorders for MAL2 Gene

Relevant External Links for MAL2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAL2 Gene

Publications for MAL2 Gene

  1. Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system. (PMID: 11549320) Wilson S.H.D. … Byrne J.A. (Genomics 2001) 2 3 4 23 67
  2. Characterization of the MAL2-positive compartment in oligodendrocytes. (PMID: 19683524) Bello-Morales R. … LA^pez-Guerrero J.A. (Exp. Cell Res. 2009) 3 23
  3. Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells. (PMID: 14576188) Marazuela M. … Alonso M.A. (Endocrinology 2004) 3 23
  4. Expression of MAL2, an integral protein component of the machinery for basolateral-to-apical transcytosis, in human epithelia. (PMID: 14729876) Marazuela M. … Alonso M.A. (J. Histochem. Cytochem. 2004) 3 23
  5. Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissue. (PMID: 15168355) Marazuela M. … Alonso M.A. (Histol. Histopathol. 2004) 3 23

Products for MAL2 Gene

Sources for MAL2 Gene