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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAL2 Gene

protein-coding   GIFtS: 46
GCID: GC08P120177

mal, T-cell differentiation protein 2 (gene/pseudogene)
 Explore 13 diseases affiliated with
MAL2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAL2    

Aliases
for MAL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mal, T-Cell Differentiation Protein 2 (Gene/Pseudogene)1 2
MAL Proteolipid Protein 22
MAL2 Proteolipid Protein2
Protein MAL22

External Ids:    HGNC: 136341   Entrez Gene: 1145692   Ensembl: ENSG000001476767   OMIM: 6096845   UniProtKB: Q969L23   

Export aliases for MAL2 gene to outside databases

Previous GC identifers: GC08P119207 GC08P120226 GC08P119889 GC08P120289 GC08P115541


Summaries
for MAL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAL2:
This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component
of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It
is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous
cargos from the basolateral to the apical surface. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MAL2_HUMAN, Q969L2
Function: Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of
the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a
raft-dependent pathway

Gene Wiki entry for MAL2


Genomic Views
for MAL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAL2 gene promoter:
         AML1a   FOXD3   Nkx2-5   XBP-1   LCR-F1   E47   Egr-4   C/EBPalpha   S8   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23   Ensembl cytogenetic band:  8q24.12   HGNC cytogenetic band: 8q23

MAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAL2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P120177:  view genomic region     (about GC identifiers)

Start:
 120,177,273 bp from pter      End:
 120,257,913 bp from pter
Size:
 80,641 bases      Orientation:
 plus strand

Proteins
for MAL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAL2_HUMAN, Q969L2 (See protein sequence)
Recommended Name: Protein MAL2  
Size: 176 amino acids; 19125 Da
Subunit: Interacts with TPD52L2
Subcellular location: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
Endomembrane system. Cytoplasm, perinuclear region. Note=Associated with lipid rafts. In polarized epithelial cells,
restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the
canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized
Hep-G2 cells, distributed to the perinuclear region
Sequence caution: Sequence=BAD18789.1; Type=Frameshift; Positions=166;
Secondary accessions: B2R520 Q6ZMD9

Explore the universe of human proteins at neXtProt for MAL2: NX_Q969L2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q969L2

    • MAL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_443118.1  
    Human Recombinant Protein Products: 
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    Novus Biologicals MAL2 Protein
    Novus Biologicals MAL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAL2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0012505endomembrane system IEA--
    GO:0016021integral to membrane IEA--
    GO:0016324apical plasma membrane IEA--
    GO:0048471perinuclear region of cytoplasm IEA--


    MAL2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MAL2

    Protein Domains /
    Families
    for MAL2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAL2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013295 MAL
     IPR021128 MARVEL-like_dom
     IPR008253 Marvel

    Graphical View of Domain Structure for InterPro Entry Q969L2

    ProtoNet protein and cluster: Q969L2

    1 Blocks protein family: IPB008253 Marvel

    UniProtKB/Swiss-Prot: MAL2_HUMAN, Q969L2
    Similarity: Belongs to the MAL family
    Similarity: Contains 1 MARVEL domain


    Function
    for MAL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MAL2_HUMAN, Q969L2
    Function: Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of
    the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a
    raft-dependent pathway

    miRNA
    Products:            		 OriGene 3'-UTR Clone: MAL2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAL2
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate MAL2 (see all 22):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-522 hsa-miR-1271 hsa-miR-374c hsa-miR-383 hsa-miR-375
    SwitchGear 3'UTR luciferase reporter plasmid: MAL2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAL2 (see all 7)
    OriGene shRNA RFP: MAL2
    OriGene siRNA: MAL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAL2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAL2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAL2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAL2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAL2 (NM_020709)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAL2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAL2
    Search LifeMap BioReagents cell lines for MAL2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAL2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12963375


    MAL2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Mal2tm1Lex for MAL2
         1 MGI phenotypic allele for Mal2 (no phenotypes)

    MAL2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAL2

    4 Interacting proteins for MAL2 (Q969L23) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPD52P553273I2D: score=4 
    TPD52L1Q168903I2D: score=3 
    TPD52L2O433993I2D: score=1 
    --Q5JWU63I2D: score=1 
    About this table

    Drugs & Compounds
    for MAL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAL2
    Search CenterWatch for drugs/clinical trials and news about MAL2 

    Transcripts
    for MAL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAL2 gene: 
    NM_052886.2  

    Unigene Cluster for MAL2:

    Mal, T-cell differentiation protein 2 (gene/pseudogene)
    Hs.201083  [show with all ESTs]
    Unigene Representative Sequence: NM_052886
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522112(lincRNA) ENST00000534619(lincRNA) ENST00000521748(lincRNA)(uc003yop.3) ENST00000531508(lincRNA)
    ENST00000276681(lincRNA)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MAL2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAL2
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate MAL2 (see all 22):
    hsa-miR-3673 hsa-miR-520d-5p hsa-miR-513a-5p hsa-miR-522 hsa-miR-1271 hsa-miR-374c hsa-miR-383 hsa-miR-375
    SwitchGear 3'UTR luciferase reporter plasmid: MAL2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAL2 (see all 7)
    OriGene shRNA RFP: MAL2
    OriGene siRNA: MAL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAL2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAL2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAL2 (NM_020709)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAL2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAL2
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAL2

    Additional cDNA sequence: 

    AK172820.1 AK312030.1 AL117612.1 AY007723.1 BC012367.1 

    7 DOTS entries:

    DT.448009  DT.99999596  DT.100680527  DT.121481771  DT.121481797  DT.121481773  DT.95074333 

    24/351 AceView cDNA sequences (see all 351):

    AI608598 AI270322 AA046853 AA173971 AI198729 BG499681 CB851506 AI493121 
    AI433931 AV704007 BM771274 CB133884 AI923647 AA173597 BM771198 F04763 
    AW473207 AI358673 BQ631354 R15940 AW780300 AA583406 AW150676 H51475 

    GeneLoc Exon Structure


    Expression
    for MAL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGAAAAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAL2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal Collecting Duct SystemKidney
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)
    Epiblast-like cells (Reconstitution of mo...)

    See MAL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAL2

    SOURCE GeneReport for Unigene cluster: Hs.201083

    UniProtKB/Swiss-Prot: MAL2_HUMAN, Q969L2
    Tissue specificity: Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at
    lower levels in testis and small intestine

        SABiosciences Custom PCR Arrays for MAL2
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAL2

    Orthologs
    for MAL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MAL2 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mal21 , 5 mal, T cell differentiation protein 21, 5 88.38(n)1
    92(a)1    		   15 (21.37 cM)5
    1058531  NM_178920.41  NP_849251.11 
     545713665 
    chicken
    (Gallus gallus)    		 Aves MAL21 mal, T-cell differentiation protein 2 68.77(n)
    66.67(a)    		   420280  NM_001012555.1  NP_001012573.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1952651 zgc:195265 59.51(n)
    58.9(a)    		   569201  NM_001135977.1  NP_001129449.1 


    ENSEMBL Gene Tree for MAL2 (if available)
    TreeFam Gene Tree for MAL2 (if available) 

    Paralogs
    for MAL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MAL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/26 NCBI SNPs in MAL2 are shown (see all 26)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs132564061,2
    		C,F,--120220148(+) CCCTAG/CTGGCG 1 -- us2k16Minor allele frequency- C:0.37NA CSA EA 248
    rs1887923761,2
    		--120220211(+) AAGTGC/TGACTG 1 -- us2k10--------
    rs750603831,2
    		C--120220236(+) ACCTTC/GTGAGT 1 -- us2k10--------
    rs1485007761,2
    		--120220245(+) GTCACA/TGCACC 1 -- us2k10--------
    rs1127989361,2
    		--120220305(+) GAGAGC/GTGGGG 1 -- us2k12Minor allele frequency- G:0.03CSA WA 119
    rs791018851,2
    		C,F,--120220400(+) GAGACG/ACCCGC 1 -- us2k13Minor allele frequency- A:0.12WA NA EA 358
    rs1428154951,2
    		--120220479(+) CTGCAA/GTAGCC 1 -- us2k10--------
    rs1925590591,2
    		--120220491(+) CACCTA/GTGCAC 1 -- us2k10--------
    rs37394201,2
    		C,--120220595(-) CCGCGA/CGGGAG 1 -- us2k10--------
    rs713029781,2
    		C,--120220776(+) CCGGG-/GTCACC 2 R fra11Minor allele frequency- G:0.00NA 2

    HapMap Linkage Disequilibrium report for MAL2 (120177273 - 120257913 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MAL2
         1 CNV: 3747

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAL2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAL2

    Disorders / Diseases
    for MAL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAL2 for disorders           About GeneDecksing

    OMIM gene information: 609684    OMIM disorders: --

    13 diseases for MAL2:    About MalaCards
    chromophobe renal cell carcinoma    renal cell carcinoma    childhood leukemia    ovarian carcinoma
    carcinoma    alzheimer's disease    breast carcinoma    cholangiocarcinoma
    prostate cancer    leukemia    prostatitis    thyroiditis
    hepatitis

    2 Novoseek disease relationships for MAL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 15.4 2 15168355 (1), 14729876 (1)
    carcinoma 8.97 2 14576188 (1), 15168355 (1)


    Export disorders for MAL2 gene to outside databases

    Publications
    for MAL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAL2 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with MAL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system. (PubMed id 11549320)1, 2, 3, 9 Wilson S.H.D.... Byrne J.A. (2001)
    2. Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells. (PubMed id 14576188)1, 2, 9 Marazuela M.... Alonso M.A. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells. (PubMed id 12370246)1, 2 de Marco M.C.... Alonso M.A. (2002)
    6. Expression of MAL2, an integral protein component of the machinery for basolateral-to-apical transcytosis, in human epithelia. (PubMed id 14729876)1, 9 Marazuela M....Alonso M.A. (2004)
    7. Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissue. (PubMed id 15168355)1, 9 Marazuela M. and Alonso M.A. (2004)
    8. Characterization of the MAL2-positive compartment in oligodendrocytes. (PubMed id 19683524)1, 9 Bello-Morales R....LA^pez-Guerrero J.A. (2009)
    9. Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line. (PubMed id 15466889)1, 9 Llorente A....Alonso M.A. (2004)
    10. Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)

    External Searches for MAL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MAL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114569 HGNC: 13634 AceView: MAL2 Ensembl:ENSG00000147676 euGenes: HUgn114569
    ECgene: MAL2 H-InvDB: MAL2

    Other Databases showing MAL2 gene

    (According to HUGE)
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    Specialized Databases showing MAL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAL2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAL2 gene:
    Search GeneIP for patents involving MAL2

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