Aliases for MAL2 Gene
External Ids for MAL2 Gene
Previous GeneCards Identifiers for MAL2 Gene
This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAL2 Gene
MAL2 (Mal, T-Cell Differentiation Protein 2 (Gene/Pseudogene)) is a Protein Coding gene. An important paralog of this gene is MAL.
UniProtKB/Swiss-Prot for MAL2 Gene
Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.