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Aliases for MAL Gene

Aliases for MAL Gene

  • Mal, T-Cell Differentiation Protein 2 3
  • T-Lymphocyte Maturation-Associated Protein 4

External Ids for MAL Gene

Previous GeneCards Identifiers for MAL Gene

  • GC02P093589
  • GC02P094125
  • GC02P095159
  • GC02P095176
  • GC02P095691
  • GC02P089724

Summaries for MAL Gene

Entrez Gene Summary for MAL Gene

  • The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]

GeneCards Summary for MAL Gene

MAL (Mal, T-Cell Differentiation Protein) is a Protein Coding gene. Diseases associated with MAL include metachromatic leukodystrophy and primary mediastinal large b-cell lymphoma. GO annotations related to this gene include lipid binding and structural constituent of myelin sheath. An important paralog of this gene is MALL.

UniProtKB/Swiss-Prot for MAL Gene

  • Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function

Gene Wiki entry for MAL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAL Gene

Genomics for MAL Gene

Regulatory Elements for MAL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAL Gene

95,025,655 bp from pter
95,053,996 bp from pter
28,342 bases
Plus strand

Genomic View for MAL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAL Gene

Proteins for MAL Gene

  • Protein details for MAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myelin and lymphocyte protein
    Protein Accession:
    Secondary Accessions:
    • Q6FH77

    Protein attributes for MAL Gene

    153 amino acids
    Molecular mass:
    16714 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAL Gene


neXtProt entry for MAL Gene

Proteomics data for MAL Gene at MOPED

Post-translational modifications for MAL Gene

Other Protein References for MAL Gene

Antibody Products

No data available for DME Specific Peptides for MAL Gene

Domains for MAL Gene

Protein Domains for MAL Gene


Graphical View of Domain Structure for InterPro Entry



  • P21145
  • Contains 1 MARVEL domain.
  • Belongs to the MAL family.
genes like me logo Genes that share domains with MAL: view

No data available for Gene Families for MAL Gene

Function for MAL Gene

Molecular function for MAL Gene

GENATLAS Biochemistry:
T-cell differentiation proteolipid protein,localized in the endoplasmic reticulum
UniProtKB/Swiss-Prot Function:
Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function

Gene Ontology (GO) - Molecular Function for MAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
GO:0008289 lipid binding TAS 10739088
GO:0015267 channel activity TAS 3494249
GO:0016505 peptidase activator activity involved in apoptotic process NAS 10366425
GO:0019911 structural constituent of myelin sheath IDA 12153479
genes like me logo Genes that share ontologies with MAL: view

Phenotypes for MAL Gene

genes like me logo Genes that share phenotypes with MAL: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MAL Gene

Localization for MAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MAL Gene COMPARTMENTS Subcellular localization image for MAL gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
endosome 4
lysosome 1

Gene Ontology (GO) - Cellular Components for MAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 9003426
GO:0005783 endoplasmic reticulum IDA 8132541
GO:0005887 integral component of plasma membrane TAS 9003426
GO:0016020 membrane --
GO:0016324 apical plasma membrane TAS 10739088
genes like me logo Genes that share ontologies with MAL: view

Pathways for MAL Gene

SuperPathways for MAL Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for MAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001766 membrane raft polarization TAS 12153479
GO:0006915 apoptotic process NAS 10366425
GO:0007417 central nervous system development TAS 10739088
GO:0030154 cell differentiation TAS 10739088
GO:0042552 myelination TAS 10428054
genes like me logo Genes that share ontologies with MAL: view

No data available for Pathways by source for MAL Gene

Compounds for MAL Gene

(4) Novoseek inferred chemical compound relationships for MAL Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 57.8 2
lipid 21.7 4
cholesterol 17.8 3
sucrose 13.4 2
genes like me logo Genes that share compounds with MAL: view

Transcripts for MAL Gene

Unigene Clusters for MAL Gene

Mal, T-cell differentiation protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: - -
SP3: - -

Relevant External Links for MAL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAL Gene

mRNA expression in normal human tissues for MAL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAL Gene

This gene is overexpressed in Esophagus - Mucosa (20.9) and Vagina (5.5).

SOURCE GeneReport for Unigene cluster for MAL Gene Hs.80395

genes like me logo Genes that share expressions with MAL: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MAL Gene

Orthologs for MAL Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAL 35
  • 80.17 (n)
  • 79.74 (a)
-- 36
  • 79 (a)
-- 36
  • 54 (a)
(Canis familiaris)
Mammalia MAL 35
  • 86.49 (n)
  • 88.24 (a)
MAL 36
  • 89 (a)
(Mus musculus)
Mammalia Mal 35
  • 85.84 (n)
  • 86.93 (a)
Mal 16
Mal 36
  • 87 (a)
(Pan troglodytes)
Mammalia MAL 35
  • 99.13 (n)
  • 99.35 (a)
MAL 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mal 35
  • 86.93 (n)
  • 88.89 (a)
(Monodelphis domestica)
Mammalia MAL 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia MAL 36
  • 37 (a)
(Gallus gallus)
Aves MAL 35
  • 62.84 (n)
  • 60.81 (a)
MAL 36
  • 61 (a)
(Anolis carolinensis)
Reptilia MAL 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mal 35
  • 57.64 (n)
  • 61.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68692 35
(Danio rerio)
Actinopterygii mal 35
  • 58.39 (n)
  • 53.69 (a)
mal 36
  • 51 (a)
MAL (2 of 3) 36
  • 44 (a)
MAL (3 of 3) 36
  • 44 (a)
Species with no ortholog for MAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAL Gene

Gene Tree for MAL (if available)
Gene Tree for MAL (if available)

Paralogs for MAL Gene

Paralogs for MAL Gene

Selected SIMAP similar genes for MAL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAL: view

Variants for MAL Gene

Sequence variations from dbSNP and Humsavar for MAL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2033 -- 95,053,837(-) GAGAC(C/T)TGTGG utr-variant-3-prime
rs1316873 -- 95,032,901(-) AAAAT(C/G)ATTCA intron-variant
rs2874283 -- 95,032,801(+) GGTCA(C/T)GAACG intron-variant
rs3105098 -- 95,032,465(-) ACTGA(C/G)ACTGG intron-variant
rs3105099 -- 95,041,774(+) TCTCC(A/G)AGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAL Gene

Variant ID Type Subtype PubMed ID
esv2660798 CNV Deletion 23128226

Relevant External Links for MAL Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAL Gene

Disorders for MAL Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MAL Gene in MalaCards »

(2) Diseases for MAL Gene including...

(2) Novoseek inferred disease relationships for MAL Gene

Disease -log(P) Hits PubMed IDs
cancer 11.2 4
tumors 0 9

Relevant External Links for MAL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MAL: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for MAL Gene

Publications for MAL Gene

  1. Genomic structure and subcellular localization of MAL, a human T- cell-specific proteolipid protein. (PMID: 8132541) Rancano C. … Alonso M.A. (J. Biol. Chem. 1994) 3 4 23
  2. Alternative splicing of human T-cell-specific MAL mRNA and its correlation with the exon/intron organization of the gene. (PMID: 8088843) Rancano C. … Alonso M.A. (Genomics 1994) 3 4 23
  3. Caveolin and MAL, two protein components of internal detergent-insoluble membranes, are in distinct lipid microenvironments in MDCK cells. (PMID: 9168919) MillA!n J. … Alonso M.A. (Biochem. Biophys. Res. Commun. 1997) 3 23
  4. The MAL proteolipid is a component of the detergent-insoluble membrane subdomains of human T-lymphocytes. (PMID: 9003426) MillA!n J. … Alonso M.A. (Biochem. J. 1997) 3 23
  5. cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation. (PMID: 3494249) Alonso M.A. … Weissman S.M. (Proc. Natl. Acad. Sci. U.S.A. 1987) 3 4

Products for MAL Gene

Sources for MAL Gene

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