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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAL Gene

protein-coding   GIFtS: 51
GCID: GC02P095691

mal, T-cell differentiation protein
 Explore 28 diseases affiliated with
MAL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAL    

Aliases
for MAL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mal, T-Cell Differentiation Protein1 2
T-Lymphocyte Maturation-Associated Protein2 3
Myelin And Lymphocyte Protein2

External Ids:    HGNC: 68171   Entrez Gene: 41182   Ensembl: ENSG000001720057   OMIM: 1888605   UniProtKB: P211453   

Export aliases for MAL gene to outside databases

Previous GC identifers: GC02P093589 GC02P094125 GC02P095159 GC02P095176 GC02P095113 GC02P089724


Summaries
for MAL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAL:
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of
proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein
in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous
system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation,
stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has
been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript
variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. (provided by
RefSeq, May 2012)

UniProtKB/Swiss-Prot: MAL_HUMAN, P21145
Function: Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical
plasma membrane. Could be involved in myelin biogenesis and/or myelin function

Gene Wiki entry for MAL


Genomic Views
for MAL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAL gene promoter:
         GR   IRF-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAL promoter sequence
   Search SABiosciences Chromatin IP Primers for MAL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.1   Ensembl cytogenetic band:  2q11.1   HGNC cytogenetic band: 2q11.1

MAL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAL gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P095691:  view genomic region     (about GC identifiers)

Start:
 95,691,422 bp from pter      End:
 95,719,737 bp from pter
Size:
 28,316 bases      Orientation:
 plus strand

Proteins
for MAL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAL_HUMAN, P21145 (See protein sequence)
Recommended Name: Myelin and lymphocyte protein  
Size: 153 amino acids; 16714 Da
Subcellular location: Membrane; Multi-pass membrane protein
Developmental stage: Expressed in the intermediate and late stages of T-cell differentiation
Secondary accessions: Q6FH77
Alternative splicing: 4 isoforms:  P21145-1   P21145-2   P21145-3   P21145-4   

Explore the universe of human proteins at neXtProt for MAL: NX_P21145

Post-translational modifications:

  • Lipoprotein1
  • View neXtProt modification sites for NX_P21145

    • MAL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_002362.1  NP_071883.1  NP_071884.1  NP_071885.1  

    ENSEMBL proteins: 
     ENSP00000310880   ENSP00000306568   ENSP00000304924   ENSP00000322860  

    Human Recombinant Protein Products: 
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    Novus Biologicals MAL Protein
    Novus Biologicals MAL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAL

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000300peripheral to membrane of membrane fraction ----
    GO:0005768endosome TAS9003426
    GO:0005783endoplasmic reticulum IDA8132541
    GO:0005887integral to plasma membrane TAS9003426
    GO:0016324apical plasma membrane TAS10739088


    MAL for ontologies           About GeneDecksing



    MAL Antibody Products: 
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    Uscn Antibodies for MAL
    Search ThermoFisher Antibodies for MAL

    Assay Products for MAL: 
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    Uscn ELISAs and CLIAs for MAL

    Protein Domains /
    Families
    for MAL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAL for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013295 MAL
     IPR021128 MARVEL-like_dom
     IPR008253 Marvel

    Graphical View of Domain Structure for InterPro Entry P21145

    ProtoNet protein and cluster: P21145

    1 Blocks protein family: IPB008253 Marvel

    UniProtKB/Swiss-Prot: MAL_HUMAN, P21145
    Similarity: Belongs to the MAL family
    Similarity: Contains 1 MARVEL domain


    Function
    for MAL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MAL_HUMAN, P21145
    Function: Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical
    plasma membrane. Could be involved in myelin biogenesis and/or myelin function

         Genatlas biochemistry entry for MAL:
    T-cell differentiation proteolipid protein,localized in the endoplasmic reticulum

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 4): MAL
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAL
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MAL (see all 10):
    hsa-miR-142-5p hsa-miR-30c hsa-miR-30d hsa-miR-340 hsa-miR-548l hsa-miR-1262 hsa-miR-30a hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmid: MAL 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAL (see all 7)
    OriGene shRNA RFP: MAL
    OriGene siRNA: MAL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAL

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAL

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAL (see all 7)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): MAL (NM_002371)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAL 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAL
    Search LifeMap BioReagents cell lines for MAL

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAL

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008289lipid binding TAS10739088
    GO:0015267channel activity TAS3494249
    GO:0016505apoptotic protease activator activity NAS10366425
    GO:0019911structural constituent of myelin sheath IDA12153479


    MAL for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Mal):
     nervous system  vision/eye 

    MAL for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for MAL (P211451 ENSP000003108804) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP7Q930091, ENSP000003435354EBI-3932027,EBI-302474 STRING: ENSP00000343535
    BTKQ061871, ENSP000003081764EBI-3932027,EBI-624835 STRING: ENSP00000308176
    SRCENSP000003509414STRING: ENSP00000350941
    PIK3R1ENSP000002743354STRING: ENSP00000274335
    PTK2ENSP000003411894STRING: ENSP00000341189
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001766membrane raft polarization TAS12153479
    GO:0006917induction of apoptosis NAS10366425
    GO:0007417central nervous system development TAS10739088
    GO:0030154cell differentiation TAS10739088
    GO:0042552myelination TAS10428054


    MAL for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAL
    4 Novoseek chemical compound relationships for MAL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 57.8 1 19445022 (1), 12776198 (1)
    lipid 21.7 5 9168919 (1), 16785208 (1), 11739628 (1), 19208741 (1)
    cholesterol 17.8 3 9168919 (1), 17494867 (1), 9126323 (1)
    sucrose 13.4 3 9168919 (1), 9003426 (1)

    Search CenterWatch for drugs/clinical trials and news about MAL 

    Transcripts
    for MAL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAL gene (4 alternative transcripts): 
    NM_002371.3  NM_022438.2  NM_022439.2  NM_022440.2  

    Unigene Cluster for MAL:

    Mal, T-cell differentiation protein
    Hs.80395  [show with all ESTs]
    Unigene Representative Sequence: AK096093
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489399 ENST00000309988(uc002stx.1 uc002sty.1 uc002stz.1 uc002sua.1)
    ENST00000353004 ENST00000354078 ENST00000349807

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 4): MAL
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAL
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MAL (see all 10):
    hsa-miR-142-5p hsa-miR-30c hsa-miR-30d hsa-miR-340 hsa-miR-548l hsa-miR-1262 hsa-miR-30a hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmid: MAL 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAL (see all 7)
    OriGene shRNA RFP: MAL
    OriGene siRNA: MAL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAL
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): MAL (NM_002371)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAL 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAL
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAL

    Additional cDNA sequence: 

    AK096093.1 AK123269.1 AK311844.1 BC000458.2 BC003006.1 CR541879.1 M15800.1 X76678.1 
    X76679.1 X76680.1 X76681.1 

    6 DOTS entries:

    DT.451570  DT.97817686  DT.95272873  DT.99935745  DT.97806374  DT.92428352 

    24/134 AceView cDNA sequences (see all 134):

    BM664675 BC000458 AW250996 AI991778 H20324 AA227594 AA341422 AU099297 
    BQ067434 X76680 BX457478 CR541879 X76681 T87640 BI755543 X76678 
    BC003006 C00666 CD674955 X76679 H19937 AK096093 AA227727 H41612 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAL    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                    -                                 
    SP2:                    -     -                           
    SP3:                    -           -                     
    SP4:                                                      


    ECgene alternative splicing isoforms for MAL

    Expression
    for MAL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGAAGACG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyUreteric BudUreteric Bud CellsKidney
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    TestisSeminiferous TubulesSertoli cellsTestis
    KidneyRenal Collecting Duct SystemKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See MAL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAL

    SOURCE GeneReport for Unigene cluster: Hs.80395
        SABiosciences Expression via Pathway-Focused PCR Arrays including MAL: 
              Multiple Sclerosis in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAL
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAL

    Orthologs
    for MAL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for MAL gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAL1 mal, T-cell differentiation protein 62.84(n)
    60.81(a)    		   416707  NM_001199391.1  NP_001186320.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAL6
    		 --
    		 57(a)
    		 1 ↔ 1
    		 1(252836056-252841007)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC686922 hypothetical protein MGC68692 71.53(n)    BC059789.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii mal1 mal, T-cell differentiation protein 58.39(n)
    53.69(a)    		   550381  NM_001017686.1  NP_001017686.1 


    ENSEMBL Gene Tree for MAL (if available)
    TreeFam Gene Tree for MAL (if available) 

    Paralogs
    for MAL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAL gene
    MALL2  PLLP2  CMTM82  
    3 SIMAP similar genes for MAL using alignment to 1 protein entry:     MAL_HUMAN:
    MALL    CMTM8    MAL2

    MAL for paralogs           About GeneDecksing



    Genomic Variants
    for MAL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/403 NCBI SNPs in MAL are shown (see all 403)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1997053141,2
    		C--95689573(+) AGGTGA/GGAGGA 4 -- us2k10--------
    rs1382676981,2
    		--95689620(+) TGGCCA/GGGCTG 4 -- us2k10--------
    rs1829286391,2
    		--95690045(+) GTCCAA/GCTAAC 4 -- us2k10--------
    rs748090551,2
    		C,F,--95690106(+) CAGCCC/TATTGT 4 -- us2k11Minor allele frequency- T:0.04WA 118
    rs775627691,2
    		C,F,--95690140(+) GACCCG/AACACA 4 -- us2k11Minor allele frequency- A:0.04WA 118
    rs22797851,2
    		C,F,H,--95690258(+) TGATGG/CGCGTG 4 -- us2k118Minor allele frequency- C:0.11EA NS NA MN 2964
    rs1853042031,2
    		--95690279(+) TTTGGA/GAAATG 4 -- us2k10--------
    rs1414387811,2
    		--95690291(+) GTCCAC/TGAATA 4 -- us2k10--------
    rs798450781,2
    		C,F,--95690355(+) TGAAGG/TCCCCA 4 -- us2k11Minor allele frequency- T:0.04NA 120
    rs1911924971,2
    		--95690446(+) GTTGCA/GGGGCC 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAL (95691422 - 95719737 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAL: --
    Human Gene Mutation Database (HGMD): MAL

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAL
    DNA2.0 Custom Variant and Variant Library Synthesis for MAL

    Disorders / Diseases
    for MAL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAL for disorders           About GeneDecksing

    OMIM gene information: 188860    OMIM disorders: --

    20/28 diseases for MAL (see all 28):    About MalaCards
    metachromatic leukodystrophy    b-cell lymphomas    fucosidosis    leukodystrophy
    epithelial ovarian cancer    squamous cell carcinoma    nephrotic syndrome    benign tumors
    embryonal carcinoma    mediastinitis    ovarian cancer    esophageal cancer
    esophagitis    colon cancer    gastric cancer    meningioma
    prostate cancer    breast cancer    carcinoma    cervicitis

    1 disease from the University of Copenhagen DISEASES database for MAL:
    Metachromatic leukodystrophy

    2 Novoseek disease relationships for MAL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 11.2 6 19642140 (1), 19002170 (1), 12776198 (1), 19662663 (1)
    tumors 0 12 15188492 (2), 19445022 (2), 12429796 (2), 19642140 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: MAL (48 documents)

    Export disorders for MAL gene to outside databases

    Publications
    for MAL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAL gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with MAL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and subcellular localization of MAL, a human T- cell-specific proteolipid protein. (PubMed id 8132541)1, 2, 9 Rancano C.... Alonso M.A. (1994)
    2. Alternative splicing of human T-cell-specific MAL mRNA and its correlation with the exon/intron organization of the gene. (PubMed id 8088843)1, 2, 9 Rancano C.... Alonso M.A. (1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation. (PubMed id 3494249)1, 2 Alonso M.A. and Weissman S.M. (1987)
    5. MAL expression in lymphoid cells: further evidence for MAL as a distinct molecular marker of primary mediastinal large B-cell lymphomas. (PubMed id 12429796)1, 9 Copie-Bergman C....Gaulard P. (2002)
    6. Elevated MAL expression is accompanied by promoter hy pomethylation and platinum resistance in epithelial ovarian cancer. (PubMed id 19642140)1, 9 Lee P.S....Murphy S.K. (2010)
    7. Expression of the MAL gene in the thyroid: the MAL proteolipid, a component of glycolipid-enriched membranes, is apically distributed in thyroid follicles. (PubMed id 9528996)1, 9 Martin-Belmonte F....Alonso M.A. (1998)
    8. T-lymphocyte maturation-associated protein gene as a candidate metastasis suppressor for head and neck squamous cell carcinomas. (PubMed id 19445022)1, 9 Beder L.B....Yamanaka N. (2009)
    9. MAL, a proteolipid in glycosphingolipid enriched domains: functional implications in myelin and beyond. (PubMed id 10739088)1, 9 Frank M. (2000)
    10. Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. (PubMed id 19208741)1, 9 Horne H.N....Marks J.R. (2009)

    External Searches for MAL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing MAL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4118 HGNC: 6817 AceView: MAL Ensembl:ENSG00000172005 euGenes: HUgn4118
    ECgene: MAL H-InvDB: MAL

    Other Databases showing MAL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAL Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAL gene:
    Search GeneIP for patents involving MAL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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