Aliases for MAL Gene
External Ids for MAL Gene
Previous GeneCards Identifiers for MAL Gene
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]
GeneCards Summary for MAL Gene
MAL (Mal, T-Cell Differentiation Protein) is a Protein Coding gene. Diseases associated with MAL include Metachromatic Leukodystrophy and Fucosidosis. GO annotations related to this gene include lipid binding and peptidase activator activity involved in apoptotic process. An important paralog of this gene is MALL.
UniProtKB/Swiss-Prot for MAL Gene
Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.