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Aliases for MAL Gene

Aliases for MAL Gene

  • Mal T-Cell Differentiation Protein 2 3
  • T-Lymphocyte Maturation-Associated Protein 3 4
  • Mal, T-Cell Differentiation Protein 3 5
  • MyD88-Adapter-Like 2 3

External Ids for MAL Gene

Previous GeneCards Identifiers for MAL Gene

  • GC02P093589
  • GC02P094125
  • GC02P095159
  • GC02P095176
  • GC02P095113
  • GC02P095691
  • GC02P089724

Summaries for MAL Gene

Entrez Gene Summary for MAL Gene

  • The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]

GeneCards Summary for MAL Gene

MAL (Mal T-Cell Differentiation Protein) is a Protein Coding gene. Diseases associated with MAL include metachromatic leukodystrophy and fucosidosis. GO annotations related to this gene include lipid binding and peptidase activator activity involved in apoptotic process. An important paralog of this gene is MAL2.

UniProtKB/Swiss-Prot for MAL Gene

  • Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.

Gene Wiki entry for MAL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAL Gene

Genomics for MAL Gene

Regulatory Elements for MAL Gene

Promoters for MAL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAL on UCSC Golden Path with GeneCards custom track

Genomic Location for MAL Gene

Chromosome:
2
Start:
95,025,655 bp from pter
End:
95,053,996 bp from pter
Size:
28,342 bases
Orientation:
Plus strand

Genomic View for MAL Gene

Genes around MAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAL Gene

Proteins for MAL Gene

  • Protein details for MAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21145-MAL_HUMAN
    Recommended name:
    Myelin and lymphocyte protein
    Protein Accession:
    P21145
    Secondary Accessions:
    • Q6FH77

    Protein attributes for MAL Gene

    Size:
    153 amino acids
    Molecular mass:
    16714 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAL Gene

Proteomics data for MAL Gene at MOPED

Post-translational modifications for MAL Gene

Other Protein References for MAL Gene

No data available for DME Specific Peptides for MAL Gene

Domains & Families for MAL Gene

Protein Domains for MAL Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P21145

UniProtKB/Swiss-Prot:

MAL_HUMAN :
  • Contains 1 MARVEL domain.
  • Belongs to the MAL family.
Domain:
  • Contains 1 MARVEL domain.
Family:
  • Belongs to the MAL family.
genes like me logo Genes that share domains with MAL: view

No data available for Gene Families for MAL Gene

Function for MAL Gene

Molecular function for MAL Gene

GENATLAS Biochemistry:
T-cell differentiation proteolipid protein,localized in the endoplasmic reticulum
UniProtKB/Swiss-Prot Function:
Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.

Gene Ontology (GO) - Molecular Function for MAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with MAL: view
genes like me logo Genes that share phenotypes with MAL: view

Animal Models for MAL Gene

MGI Knock Outs for MAL:

Animal Model Products

miRNA for MAL Gene

miRTarBase miRNAs that target MAL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAL Gene

Localization for MAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAL Gene COMPARTMENTS Subcellular localization image for MAL gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
endosome 4
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 9003426
GO:0016020 membrane IEA --
GO:0019898 extrinsic component of membrane IEA --
genes like me logo Genes that share ontologies with MAL: view

Pathways & Interactions for MAL Gene

SuperPathways for MAL Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042552 myelination TAS 10428054
GO:0045176 apical protein localization TAS 10739088
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA --
genes like me logo Genes that share ontologies with MAL: view

No data available for Pathways by source and SIGNOR curated interactions for MAL Gene

Drugs & Compounds for MAL Gene

(4) Drugs for MAL Gene - From: Novoseek and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methyl 5-aminolevulinate Pharma 52
Photosensitizing Agents Pharma 374

(2) Additional Compounds for MAL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAL: view

Transcripts for MAL Gene

Unigene Clusters for MAL Gene

Mal, T-cell differentiation protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for MAL Gene

GeneLoc Exon Structure for
MAL
ECgene alternative splicing isoforms for
MAL

Expression for MAL Gene

mRNA expression in normal human tissues for MAL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAL Gene

This gene is overexpressed in Esophagus - Mucosa (x20.9) and Vagina (x5.5).

SOURCE GeneReport for Unigene cluster for MAL Gene Hs.80395

genes like me logo Genes that share expression patterns with MAL: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MAL Gene

Orthologs for MAL Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAL 35
  • 80.17 (n)
  • 79.74 (a)
-- 36
  • 79 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MAL 35
  • 86.49 (n)
  • 88.24 (a)
MAL 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mal 35
  • 85.84 (n)
  • 86.93 (a)
Mal 16
Mal 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAL 35
  • 99.13 (n)
  • 99.35 (a)
MAL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mal 35
  • 86.93 (n)
  • 88.89 (a)
oppossum
(Monodelphis domestica)
Mammalia MAL 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAL 36
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAL 35
  • 62.84 (n)
  • 60.81 (a)
MAL 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAL 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mal 35
  • 57.64 (n)
  • 61.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68692 35
zebrafish
(Danio rerio)
Actinopterygii mal 35
  • 58.39 (n)
  • 53.69 (a)
mal 36
  • 51 (a)
OneToMany
MAL (2 of 3) 36
  • 44 (a)
OneToMany
MAL (3 of 3) 36
  • 44 (a)
OneToMany
Species with no ortholog for MAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAL Gene

ENSEMBL:
Gene Tree for MAL (if available)
TreeFam:
Gene Tree for MAL (if available)

Paralogs for MAL Gene

Paralogs for MAL Gene

(3) SIMAP similar genes for MAL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAL: view

Variants for MAL Gene

Sequence variations from dbSNP and Humsavar for MAL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2033 -- 95,053,837(-) GAGAC(C/T)TGTGG utr-variant-3-prime
rs1316873 -- 95,032,901(-) AAAAT(C/G)ATTCA intron-variant
rs2279785 -- 95,024,513(+) TGATG(C/G)GCGTG upstream-variant-2KB
rs3105098 -- 95,032,465(-) ACTGA(C/G)ACTGG intron-variant
rs3105099 -- 95,041,774(+) TCTCC(A/G)AGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAL Gene

Variant ID Type Subtype PubMed ID
esv2660798 CNV Deletion 23128226

Variation tolerance for MAL Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAL Gene

HapMap Linkage Disequilibrium report
MAL
Human Gene Mutation Database (HGMD)
MAL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAL Gene

Disorders for MAL Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAL Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
metachromatic leukodystrophy
  • arylsulfatase a deficiency
fucosidosis
  • a-fucosidase deficiency
esophageal cancer
  • esophageal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search MAL in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAL

Genetic Association Database (GAD)
MAL
Human Genome Epidemiology (HuGE) Navigator
MAL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAL
genes like me logo Genes that share disorders with MAL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAL Gene

Publications for MAL Gene

  1. Genomic structure and subcellular localization of MAL, a human T- cell-specific proteolipid protein. (PMID: 8132541) Rancano C. … Alonso M.A. (J. Biol. Chem. 1994) 3 4 23 67
  2. Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer. (PMID: 19642140) Lee P.S. … Murphy S.K. (Int. J. Cancer 2010) 3 23
  3. T-lymphocyte maturation-associated protein gene as a candidate metastasis suppressor for head and neck squamous cell carcinomas. (PMID: 19445022) Beder L.B. … Yamanaka N. (Cancer Sci. 2009) 3 23
  4. Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. (PMID: 19208741) Horne H.N. … Marks J.R. (Mol. Cancer Res. 2009) 3 23
  5. MAL promoter hypermethylation as a novel prognostic marker in gastric cancer. (PMID: 19002170) Buffart T.E. … Meijer G.A. (Br. J. Cancer 2008) 3 23

Products for MAL Gene

Sources for MAL Gene

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