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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAL Gene

protein-coding   GIFtS: 52
GCID: GC02P095691

Mal, T-Cell Differentiation Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mal, T-Cell Differentiation Protein1 2
T-Lymphocyte Maturation-Associated Protein2 3
Myelin And Lymphocyte Protein2

External Ids:    HGNC: 68171   Entrez Gene: 41182   Ensembl: ENSG000001720057   OMIM: 1888605   UniProtKB: P211453   

Export aliases for MAL gene to outside databases

Previous GC identifers: GC02P093589 GC02P094125 GC02P095159 GC02P095176 GC02P095113 GC02P089724


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAL Gene:
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of
proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker
protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in
the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the
formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of
this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four
transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.
(provided by RefSeq, May 2012)

GeneCards Summary for MAL Gene: 
MAL (mal, T-cell differentiation protein) is a protein-coding gene. Diseases associated with MAL include primary mediastinal large b-cell lymphoma, and metachromatic leukodystrophy. GO annotations related to this gene include lipid binding and structural constituent of myelin sheath. An important paralog of this gene is MAL2.

UniProtKB/Swiss-Prot: MAL_HUMAN, P21145
Function: Could be an important component in vesicular trafficking cycling between the Golgi complex and the
apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function

Gene Wiki entry for MAL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAL gene promoter:
         GR   IRF-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAL promoter sequence
   Search SABiosciences Chromatin IP Primers for MAL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.1   Ensembl cytogenetic band:  2q11.1   HGNC cytogenetic band: 2q11.1

MAL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAL gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P095691:  view genomic region     (about GC identifiers)

Start:
95,691,422 bp from pter      End:
95,719,737 bp from pter
Size:
28,316 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAL_HUMAN, P21145 (See protein sequence)
Recommended Name: Myelin and lymphocyte protein  
Size: 153 amino acids; 16714 Da
Subcellular location: Membrane; Multi-pass membrane protein
Developmental stage: Expressed in the intermediate and late stages of T-cell differentiation
Secondary accessions: Q6FH77
Alternative splicing: 4 isoforms:  P21145-1   P21145-2   P21145-3   P21145-4   

Explore the universe of human proteins at neXtProt for MAL: NX_P21145

Explore proteomics data for MAL at MOPED 

Post-translational modifications:

  • UniProtKB: Lipoprotein
  • View neXtProt modification sites for NX_P21145

  • MAL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAL Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_002362.1  NP_071883.1  NP_071884.1  NP_071885.1  

    ENSEMBL proteins: 
     ENSP00000310880   ENSP00000306568   ENSP00000304924   ENSP00000322860  

    Human Recombinant Protein Products for MAL: 
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    OriGene Purified Proteins for MAL
    OriGene Protein Over-expression Lysate for MAL
    OriGene MassSpec for MAL 
    OriGene Custom Protein Services for MAL
    GenScript Custom Purified and Recombinant Proteins Services for MAL
    Novus Biologicals MAL Protein
    Novus Biologicals MAL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAL 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome TAS9003426
    GO:0005783endoplasmic reticulum IDA8132541
    GO:0005887integral to plasma membrane TAS9003426
    GO:0016324apical plasma membrane TAS10739088
    GO:0019898extrinsic to membrane IEA--

    MAL for ontologies           About GeneDecksing



    MAL Antibody Products: 
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    Abcam antibodies for MAL
    Cloud-Clone Corp. Antibodies for MAL 
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    LSBio Antibodies in human, mouse, rat for MAL 

    Assay Products for MAL: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MAL 
    Cloud-Clone Corp. CLIAs for MAL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013295 MAL
     IPR021128 MARVEL-like_dom
     IPR008253 Marvel

    Graphical View of Domain Structure for InterPro Entry P21145

    ProtoNet protein and cluster: P21145

    1 Blocks protein domain: IPB008253 Marvel

    UniProtKB/Swiss-Prot: MAL_HUMAN, P21145
    Similarity: Belongs to the MAL family
    Similarity: Contains 1 MARVEL domain


    MAL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAL_HUMAN, P21145
    Function: Could be an important component in vesicular trafficking cycling between the Golgi complex and the
    apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function

         Genatlas biochemistry entry for MAL:
    T-cell differentiation proteolipid protein,localized in the endoplasmic reticulum

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008289lipid binding TAS10739088
    GO:0015267channel activity TAS3494249
    GO:0016505peptidase activator activity involved in apoptotic process NAS10366425
    GO:0019911structural constituent of myelin sheath IDA12153479
         
    MAL for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mal):
     nervous system  vision/eye 

    MAL for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAL 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAL
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MAL (see all 10):
    hsa-miR-142-5p hsa-miR-30c hsa-miR-30d hsa-miR-340 hsa-miR-548l hsa-miR-1262 hsa-miR-30a hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmidMAL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAL

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MAL

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAL (see all 23)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAL (NM_002371)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAL
    Sirion Biotech Customized lentivirus for stable overexpression of MAL 
                         Customized lentivirus expression plasmids for stable overexpression of MAL 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAL
    Search LifeMap BioReagents cell lines for MAL
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for MAL (P211451 ENSP000003108804) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP7Q930091, ENSP000003435354EBI-3932027,EBI-302474 STRING: ENSP00000343535
    BTKQ061871, ENSP000003081764EBI-3932027,EBI-624835 STRING: ENSP00000308176
    SRCENSP000003509414STRING: ENSP00000350941
    PIK3R1ENSP000002743354STRING: ENSP00000274335
    PTK2ENSP000003411894STRING: ENSP00000341189
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001766membrane raft polarization TAS12153479
    GO:0006915apoptotic process NAS10366425
    GO:0007417central nervous system development TAS10739088
    GO:0030154cell differentiation TAS10739088
    GO:0042552myelination TAS10428054

    MAL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAL

    4 Novoseek inferred chemical compound relationships for MAL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 57.8 1 19445022 (1), 12776198 (1)
    lipid 21.7 5 9168919 (1), 16785208 (1), 11739628 (1), 19208741 (1)
    cholesterol 17.8 3 9168919 (1), 17494867 (1), 9126323 (1)
    sucrose 13.4 3 9168919 (1), 9003426 (1)

    Search CenterWatch for drugs/clinical trials and news about MAL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAL gene (4 alternative transcripts): 
    NM_002371.3  NM_022438.2  NM_022439.2  NM_022440.2  

    Unigene Cluster for MAL:

    Mal, T-cell differentiation protein
    Hs.80395  [show with all ESTs]
    Unigene Representative Sequence: AK096093
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489399 ENST00000309988(uc002stx.1 uc002sty.1 uc002stz.1 uc002sua.1)
    ENST00000353004 ENST00000354078 ENST00000349807

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAL
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate MAL (see all 10):
    hsa-miR-142-5p hsa-miR-30c hsa-miR-30d hsa-miR-340 hsa-miR-548l hsa-miR-1262 hsa-miR-30a hsa-miR-30b
    SwitchGear 3'UTR luciferase reporter plasmidMAL 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAL
    Clone
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    OriGene clones in human, mouse for MAL (see all 23)
    OriGene ORF clones in mouse, rat for MAL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAL (NM_002371)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAL
    Sirion Biotech Customized lentivirus for stable overexpression of MAL 
                         Customized lentivirus expression plasmids for stable overexpression of MAL 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAL
    OriGene qSTAR qPCR primer pairs in human, mouse for MAL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAL

    Additional mRNA sequence: 

    AK096093.1 AK123269.1 AK311844.1 BC000458.2 BC003006.1 CR541879.1 M15800.1 X76678.1 
    X76679.1 X76680.1 X76681.1 

    6 DOTS entries:

    DT.451570  DT.97817686  DT.95272873  DT.99935745  DT.97806374  DT.92428352 

    24/134 AceView cDNA sequences (see all 134):

    X76680 H19937 CR541879 T87640 X76681 BX457478 AI991778 H41612 
    X76678 AA227727 AA227594 AU099297 AA341422 NM_002371 BM703177 CD674955 
    BC003006 X76679 C00666 AK096093 H20324 AA025979 AW250996 BI755543 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAL    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                    -                                 
    SP2:                    -     -                           
    SP3:                    -           -                     
    SP4:                                                      


    ECgene alternative splicing isoforms for MAL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAL expression in normal human tissues (normalized intensities)      MAL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGAAGACG
    MAL Expression
    About this image


    MAL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Kidney (Urinary System)    fully expand to see all 7 entries
             Renal Collecting Duct System
             Human Renal Mesangial Cells (HRMC)   
             visceral organ/metanephros/calyx   
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Double Negative 3 Thymocytes Thymus
             Peripheral blood Pan-T Cells   
     
     Epithelium (Uncategorized)    fully expand to see all 4 entries
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
             Human Pulmonary Microvascular Endothelial Cells (HPMEC)   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
             Olfactory Bulb   

    See MAL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAL

    SOURCE GeneReport for Unigene cluster: Hs.80395
        SABiosciences Expression via Pathway-Focused PCR Arrays including MAL: 
              Multiple Sclerosis in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat
              Apoptosis 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAL
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAL
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MAL gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mal1 , 5 myelin and lymphocyte protein, T cell differentiation more1, 5 85.84(n)1
    86.93(a)1
      2 (62.06 cM)5
    171531  NM_010762.51  NP_034892.11 
     1276332265 
    chicken
    (Gallus gallus)
    Aves MAL1 mal, T-cell differentiation protein 62.84(n)
    60.81(a)
      416707  NM_001199391.1  NP_001186320.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAL6
    Uncharacterized protein
    58(a)
    1 ↔ 1
    1(252836019-252841007)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686922 hypothetical protein MGC68692 71.53(n)    BC059789.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mal1 mal, T-cell differentiation protein 58.39(n)
    53.69(a)
      550381  NM_001017686.1  NP_001017686.1 


    ENSEMBL Gene Tree for MAL (if available)
    TreeFam Gene Tree for MAL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAL gene
    MAL22  MALL2  
    3 SIMAP similar genes for MAL using alignment to 1 protein entry:     MAL_HUMAN:
    MALL    CMTM8    MAL2

    MAL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/493 SNPs in MAL are shown (see all 493)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1997053141,2
    C--95689573(+) AGGTGA/GGAGGA 4 -- us2k10--------
    rs1382676981,2
    C--95689620(+) TGGCCA/GGGCTG 4 -- us2k10--------
    rs1829286391,2
    --95690045(+) GTCCAA/GCTAAC 4 -- us2k10--------
    rs748090551,2
    C,F--95690106(+) CAGCCC/TATTGT 4 -- us2k11Minor allele frequency- T:0.04WA 118
    rs775627691,2
    C,F--95690140(+) GACCCG/AACACA 4 -- us2k11Minor allele frequency- A:0.04WA 118
    rs22797851,2
    C,F,H--95690258(+) TGATGG/CGCGTG 4 -- us2k118Minor allele frequency- C:0.11EA NS NA MN 2964
    rs1853042031,2
    --95690279(+) TTTGGA/GAAATG 4 -- us2k10--------
    rs1414387811,2
    --95690291(+) GTCCAC/TGAATA 4 -- us2k10--------
    rs798450781,2
    C,F--95690355(+) TGAAGG/TCCCCA 4 -- us2k11Minor allele frequency- T:0.04NA 120
    rs1911924971,2
    --95690446(+) GTTGCA/GGGGCC 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAL (95691422 - 95719737 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MAL:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660798CNV Deletion23128226


    Human Gene Mutation Database (HGMD): MAL
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAL
    DNA2.0 Custom Variant and Variant Library Synthesis for MAL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 188860    OMIM disorders: --

    20/26 diseases for MAL (see all 26):    About MalaCards
    primary mediastinal large b-cell lymphoma    metachromatic leukodystrophy    fucosidosis    mediastinitis
    leukodystrophy    benign tumors    nephrotic syndrome    esophageal cancer
    malaria    meningioma    b-cell lymphomas    ovarian cancer
    parkinson's disease    esophagitis    colon cancer    gastric cancer
    multiple sclerosis    squamous cell carcinoma    cervicitis    thyroiditis


    MAL for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for MAL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 11.2 6 19642140 (1), 19002170 (1), 12776198 (1), 19662663 (1)
    tumors 0 12 15188492 (2), 19445022 (2), 12429796 (2), 19642140 (1) (see all 6)

    Genetic Association Database (GAD): MAL
    Human Genome Epidemiology (HuGE) Navigator: MAL (48 documents)

    Export disorders for MAL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAL gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with MAL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and subcellular localization of MAL, a human T- cell-specific proteolipid protein. (PubMed id 8132541)1, 2, 9 Rancano C.... Alonso M.A. (1994)
    2. Alternative splicing of human T-cell-specific MAL mRNA and its correlation with the exon/intron organization of the gene. (PubMed id 8088843)1, 2, 9 Rancano C.... Alonso M.A. (1994)
    3. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    4. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    5. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation. (PubMed id 3494249)1, 2 Alonso M.A. and Weissman S.M. (1987)
    8. MAL expression in lymphoid cells: further evidence for MAL as a distinct molecular marker of primary mediastinal large B-cell lymphomas. (PubMed id 12429796)1, 9 Copie-Bergman C....Gaulard P. (2002)
    9. Elevated MAL expression is accompanied by promoter hy pomethylation and platinum resistance in epithelial ovarian cancer. (PubMed id 19642140)1, 9 Lee P.S....Murphy S.K. (2010)
    10. Expression of the MAL gene in the thyroid: the MAL proteolipid, a component of glycolipid-enriched membranes, is apically distributed in thyroid follicles. (PubMed id 9528996)1, 9 Martin-Belmonte F....Alonso M.A. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4118 HGNC: 6817 AceView: MAL Ensembl:ENSG00000172005 euGenes: HUgn4118
    ECgene: MAL H-InvDB: MAL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAL gene:
    Search GeneIP for patents involving MAL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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