Aliases for MAL Gene
External Ids for MAL Gene
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]
GeneCards Summary for MAL Gene
MAL (Mal, T-Cell Differentiation Protein) is a Protein Coding gene. Diseases associated with MAL include metachromatic leukodystrophy and primary mediastinal large b-cell lymphoma. GO annotations related to this gene include lipid binding and structural constituent of myelin sheath. An important paralog of this gene is MALL.
UniProtKB/Swiss-Prot for MAL Gene
Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function