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Aliases for MAK16 Gene

Aliases for MAK16 Gene

  • MAK16 Homolog 2 3 5
  • RNA Binding Motif Protein 13 2 3
  • RBM13 3 4
  • NNP78 3 4
  • MAK16 Homolog (S. Cerevisiae) 2
  • Protein MAK16 Homolog 3
  • RNA Binding Protein 3
  • Protein RBM13 4
  • MAK16L 3

External Ids for MAK16 Gene

Previous HGNC Symbols for MAK16 Gene

  • RBM13

Previous GeneCards Identifiers for MAK16 Gene

  • GC08P033342
  • GC08P031874

Summaries for MAK16 Gene

GeneCards Summary for MAK16 Gene

MAK16 (MAK16 Homolog) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for MAK16 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAK16 Gene

Genomics for MAK16 Gene

Regulatory Elements for MAK16 Gene

Enhancers for MAK16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F033511 1.2 ENCODE 22.6 +28.9 28911 3.4 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF548 ZNF263 SP3 NFYC TTI2 FUT10 MAK16 RNF122 LOC100630919
GH08F033574 0.9 FANTOM5 Ensembl 11.1 +90.0 90034 0.8 TBP POLR2A CREB3L1 NFYB NR4A1 SUPT5H MGA FUT10 LOC100630919 SNORD13 TTI2 ENSG00000252505 RPL10P18 MAK16 RNF122 RN7SL621P
GH08F033580 0.8 ENCODE 10.9 +96.8 96768 1.6 ELF3 TBP ATF1 ARID4B DMAP1 ZNF48 ZSCAN9 CREM MIXL1 THAP11 FUT10 LOC100630919 TTI2 SNORD13 RPL10P18 ENSG00000252505 MAK16 RNF122 GC08P033581 DUSP26
GH08F032685 0.6 ENCODE 10.8 -798.6 -798630 1.8 ZFP64 CEBPB ZNF140 ZNF518A ZNF781 JUND PRDM12 FOS MAK16 GC08M032358 RNU6-663P GC08M032912
GH08F033569 0.5 Ensembl 10.8 +85.3 85251 0.4 JUND ATF3 HMBOX1 ENSG00000252505 RPL10P18 LOC100630919 SNORD13 TTI2 MAK16 RNF122 RN7SL621P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAK16 on UCSC Golden Path with GeneCards custom track

Promoters for MAK16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001389581 550 2201 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for MAK16 Gene

Chromosome:
8
Start:
33,484,750 bp from pter
End:
33,501,260 bp from pter
Size:
16,511 bases
Orientation:
Plus strand

Genomic View for MAK16 Gene

Genes around MAK16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAK16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAK16 Gene

Proteins for MAK16 Gene

  • Protein details for MAK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXY0-MAK16_HUMAN
    Recommended name:
    Protein MAK16 homolog
    Protein Accession:
    Q9BXY0
    Secondary Accessions:
    • B2RB44
    • Q5U5T1
    • Q86UC4
    • Q96SY6

    Protein attributes for MAK16 Gene

    Size:
    300 amino acids
    Molecular mass:
    35369 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAK16 Gene

Post-translational modifications for MAK16 Gene

  • Ubiquitination at Lys 115
  • Modification sites at PhosphoSitePlus

Other Protein References for MAK16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAK16 Gene

Domains & Families for MAK16 Gene

Gene Families for MAK16 Gene

Protein Domains for MAK16 Gene

Suggested Antigen Peptide Sequences for MAK16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXY0

UniProtKB/Swiss-Prot:

MAK16_HUMAN :
  • Belongs to the MAK16 family.
Family:
  • Belongs to the MAK16 family.
genes like me logo Genes that share domains with MAK16: view

Function for MAK16 Gene

Gene Ontology (GO) - Molecular Function for MAK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MAK16: view
genes like me logo Genes that share phenotypes with MAK16: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAK16 Gene

Localization for MAK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAK16 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAK16 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for MAK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0030687 preribosome, large subunit precursor IBA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with MAK16: view

Pathways & Interactions for MAK16 Gene

SuperPathways for MAK16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IBA --
GO:0000470 maturation of LSU-rRNA IBA --
genes like me logo Genes that share ontologies with MAK16: view

No data available for Pathways by source and SIGNOR curated interactions for MAK16 Gene

Transcripts for MAK16 Gene

Unigene Clusters for MAK16 Gene

MAK16 homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAK16 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - -
SP2: - -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for MAK16 Gene

GeneLoc Exon Structure for
MAK16
ECgene alternative splicing isoforms for
MAK16

Expression for MAK16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAK16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAK16 Gene

This gene is overexpressed in Fetal ovary (14.4), Liver (13.7), Adrenal (10.5), Peripheral blood mononuclear cells (10.3), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAK16 Gene



Protein tissue co-expression partners for MAK16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAK16 Gene:

MAK16

SOURCE GeneReport for Unigene cluster for MAK16 Gene:

Hs.583805
genes like me logo Genes that share expression patterns with MAK16: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAK16 Gene

Orthologs for MAK16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAK16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAK16 34 35
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia MAK16 34 35
  • 91.16 (n)
cow
(Bos Taurus)
Mammalia MAK16 34 35
  • 90.94 (n)
mouse
(Mus musculus)
Mammalia Mak16 34 16 35
  • 86.6 (n)
rat
(Rattus norvegicus)
Mammalia Mak16 34
  • 86.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAK16 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAK16 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAK16 34 35
  • 74.89 (n)
lizard
(Anolis carolinensis)
Reptilia MAK16 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mak16 34
  • 74.05 (n)
MGC75652 34
African clawed frog
(Xenopus laevis)
Amphibia mak16l-prov 34
zebrafish
(Danio rerio)
Actinopterygii mak16 34 35
  • 69.82 (n)
mak16l 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000514 34
  • 61.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rbm13 35
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C16A3.6 34 35
  • 55.97 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04037g 34
  • 56.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK16 34 35 37
  • 54.81 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR349W 34
  • 53.55 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G23280 34
  • 54.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 59 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mak16 34
  • 54.3 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04150 34
  • 53.38 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4373 34
Species where no ortholog for MAK16 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAK16 Gene

ENSEMBL:
Gene Tree for MAK16 (if available)
TreeFam:
Gene Tree for MAK16 (if available)

Paralogs for MAK16 Gene

No data available for Paralogs for MAK16 Gene

Variants for MAK16 Gene

Sequence variations from dbSNP and Humsavar for MAK16 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs398122367 Pathogenic 33,500,443(-) ACTGA(A/T)TTGTG reference, missense, utr-variant-3-prime
rs10097189 -- 33,484,926(+) CGCGT(C/G)CTGCC upstream-variant-2KB
rs10103847 -- 33,491,867(+) gggct(C/T)aagca intron-variant
rs10111551 -- 33,484,999(+) CCAGC(A/G)TTGCG upstream-variant-2KB
rs10644 -- 33,500,644(+) CAAAG(A/T)CAGCC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAK16 Gene

Variant ID Type Subtype PubMed ID
nsv1117819 CNV deletion 24896259
esv3576539 CNV gain 25503493

Variation tolerance for MAK16 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAK16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAK16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAK16 Gene

Disorders for MAK16 Gene

Relevant External Links for MAK16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAK16

No disorders were found for MAK16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAK16 Gene

Publications for MAK16 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Directed proteomic analysis of the human nucleolus. (PMID: 11790298) Andersen J.S. … Lamond A.I. (Curr. Biol. 2002) 3 4 64
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4 64

Products for MAK16 Gene

Sources for MAK16 Gene

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