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Aliases for MAK16 Gene

Aliases for MAK16 Gene

  • MAK16 Homolog 2 3 5
  • RNA Binding Motif Protein 13 2 3
  • RBM13 3 4
  • NNP78 3 4
  • MAK16 Homolog (S. Cerevisiae) 2
  • Protein MAK16 Homolog 3
  • RNA Binding Protein 3
  • Protein RBM13 4
  • MAK16L 3

External Ids for MAK16 Gene

Previous HGNC Symbols for MAK16 Gene

  • RBM13

Previous GeneCards Identifiers for MAK16 Gene

  • GC08P033342
  • GC08P031874

Summaries for MAK16 Gene

GeneCards Summary for MAK16 Gene

MAK16 (MAK16 Homolog) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for MAK16 Gene

Additional gene information for MAK16 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAK16 Gene

Genomics for MAK16 Gene

Regulatory Elements for MAK16 Gene

Enhancers for MAK16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H033511 1.2 ENCODE 30.7 +28.9 28911 3.4 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF548 SP3 NFYC SSRP1 ZNF610 TTI2 FUT10 MAK16 RNF122 LOC100630919
GH08H033574 0.9 FANTOM5 Ensembl 11.2 +90.0 90034 0.8 MTA3 POLR2A SMAD5 NR4A1 NFYB MGA SUPT5H FUT10 LOC100630919 TTI2 SNORD13 RPL10P18 ENSG00000252505 MAK16 RNF122 RN7SL621P
GH08H033580 0.8 ENCODE 10.9 +96.8 96768 1.6 ELF3 SOX13 TBP DRAP1 ATF1 SAP130 ARID4B DMAP1 ZSCAN9 TEAD3 FUT10 LOC100630919 TTI2 SNORD13 ENSG00000252505 RPL10P18 MAK16 RNF122 GC08P033581 DUSP26
GH08H033433 0.3 FANTOM5 12.7 -50.7 -50651 0.4 MAK16 RPL10P18 ENSG00000252505 FUT10 TTI2 LOC100507379 PIR51386
GH08H033207 0.5 FANTOM5 2.7 -277.4 -277443 0.2 GATA3 JUND TTI2 FUT10 MAK16 ENSG00000253993 GC08P033066
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAK16 on UCSC Golden Path with GeneCards custom track

Promoters for MAK16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000223335 550 1801 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Locations for MAK16 Gene

Genomic Locations for MAK16 Gene
chr8:33,484,750-33,501,260
(GRCh38/hg38)
Size:
16,511 bases
Orientation:
Plus strand
chr8:33,342,268-33,358,778
(GRCh37/hg19)

Genomic View for MAK16 Gene

Genes around MAK16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAK16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAK16 Gene

Proteins for MAK16 Gene

  • Protein details for MAK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXY0-MAK16_HUMAN
    Recommended name:
    Protein MAK16 homolog
    Protein Accession:
    Q9BXY0
    Secondary Accessions:
    • B2RB44
    • Q5U5T1
    • Q86UC4
    • Q96SY6

    Protein attributes for MAK16 Gene

    Size:
    300 amino acids
    Molecular mass:
    35369 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAK16 Gene

Post-translational modifications for MAK16 Gene

  • Ubiquitination at posLast=115115
  • Modification sites at PhosphoSitePlus

Other Protein References for MAK16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAK16 Gene

Domains & Families for MAK16 Gene

Gene Families for MAK16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAK16 Gene

Suggested Antigen Peptide Sequences for MAK16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXY0

UniProtKB/Swiss-Prot:

MAK16_HUMAN :
  • Belongs to the MAK16 family.
Family:
  • Belongs to the MAK16 family.
genes like me logo Genes that share domains with MAK16: view

Function for MAK16 Gene

Gene Ontology (GO) - Molecular Function for MAK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MAK16: view
genes like me logo Genes that share phenotypes with MAK16: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAK16 Gene

Localization for MAK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAK16 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAK16 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IBA,IDA --
GO:0030687 preribosome, large subunit precursor IBA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with MAK16: view

Pathways & Interactions for MAK16 Gene

SuperPathways for MAK16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IBA --
GO:0000470 maturation of LSU-rRNA IBA --
genes like me logo Genes that share ontologies with MAK16: view

No data available for Pathways by source and SIGNOR curated interactions for MAK16 Gene

Drugs & Compounds for MAK16 Gene

No Compound Related Data Available

Transcripts for MAK16 Gene

Unigene Clusters for MAK16 Gene

MAK16 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAK16 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - -
SP2: - -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for MAK16 Gene

GeneLoc Exon Structure for
MAK16
ECgene alternative splicing isoforms for
MAK16

Expression for MAK16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAK16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAK16 Gene

This gene is overexpressed in Fetal ovary (14.4), Liver (13.7), Adrenal (10.5), Peripheral blood mononuclear cells (10.3), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAK16 Gene



Protein tissue co-expression partners for MAK16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAK16 Gene:

MAK16

SOURCE GeneReport for Unigene cluster for MAK16 Gene:

Hs.583805

Evidence on tissue expression from TISSUES for MAK16 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with MAK16: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAK16 Gene

Orthologs for MAK16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAK16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAK16 33 34
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia MAK16 33 34
  • 91.16 (n)
cow
(Bos Taurus)
Mammalia MAK16 33 34
  • 90.94 (n)
mouse
(Mus musculus)
Mammalia Mak16 33 16 34
  • 86.6 (n)
rat
(Rattus norvegicus)
Mammalia Mak16 33
  • 86.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAK16 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAK16 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAK16 33 34
  • 74.89 (n)
lizard
(Anolis carolinensis)
Reptilia MAK16 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mak16 33
  • 74.05 (n)
MGC75652 33
African clawed frog
(Xenopus laevis)
Amphibia mak16l-prov 33
zebrafish
(Danio rerio)
Actinopterygii mak16 33 34
  • 69.82 (n)
mak16l 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000514 33
  • 61.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rbm13 34
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C16A3.6 33 34
  • 55.97 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04037g 33
  • 56.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK16 33 34 36
  • 54.81 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR349W 33
  • 53.55 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G23280 33
  • 54.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mak16 33
  • 54.3 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04150 33
  • 53.38 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4373 33
Species where no ortholog for MAK16 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAK16 Gene

ENSEMBL:
Gene Tree for MAK16 (if available)
TreeFam:
Gene Tree for MAK16 (if available)

Paralogs for MAK16 Gene

No data available for Paralogs for MAK16 Gene

Variants for MAK16 Gene

Sequence variations from dbSNP and Humsavar for MAK16 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs398122367 Pathogenic 33,500,443(-) ACTGA(A/T)TTGTG reference, missense, utr-variant-3-prime
rs1000107618 -- 33,492,491(+) CTATG(A/G)CCTGG intron-variant
rs1000497496 -- 33,484,529(+) TTTGT(A/T)TGTTG upstream-variant-2KB
rs1000609111 -- 33,497,389(+) GTTCA(C/T)TCCTA intron-variant
rs1000774633 -- 33,484,737(+) GGGGC(C/T)GGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAK16 Gene

Variant ID Type Subtype PubMed ID
nsv1117819 CNV deletion 24896259
esv3576539 CNV gain 25503493

Variation tolerance for MAK16 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAK16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAK16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAK16 Gene

Disorders for MAK16 Gene

Relevant External Links for MAK16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAK16

No disorders were found for MAK16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAK16 Gene

Publications for MAK16 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Directed proteomic analysis of the human nucleolus. (PMID: 11790298) Andersen JS … Lamond AI (Current biology : CB 2002) 3 4 60
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 60

Products for MAK16 Gene

Sources for MAK16 Gene

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