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Aliases for MAK16 Gene

Aliases for MAK16 Gene

  • MAK16 Homolog 2 3
  • RNA Binding Motif Protein 13 2 3
  • RBM13 3 4
  • NNP78 3 4
  • MAK16 Homolog (S. Cerevisiae) 2
  • RNA Binding Protein 3
  • Protein RBM13 4
  • MAK16L 3

External Ids for MAK16 Gene

Previous HGNC Symbols for MAK16 Gene

  • RBM13

Previous GeneCards Identifiers for MAK16 Gene

  • GC08P033342
  • GC08P031874

Summaries for MAK16 Gene

GeneCards Summary for MAK16 Gene

MAK16 (MAK16 Homolog) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for MAK16 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAK16 Gene

Genomics for MAK16 Gene

Regulatory Elements for MAK16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAK16 Gene

33,484,750 bp from pter
33,501,260 bp from pter
16,511 bases
Plus strand

Genomic View for MAK16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAK16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAK16 Gene

Proteins for MAK16 Gene

  • Protein details for MAK16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein MAK16 homolog
    Protein Accession:
    Secondary Accessions:
    • B2RB44
    • Q5U5T1
    • Q86UC4
    • Q96SY6

    Protein attributes for MAK16 Gene

    300 amino acids
    Molecular mass:
    35369 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAK16 Gene

Proteomics data for MAK16 Gene at MOPED

Post-translational modifications for MAK16 Gene

  • Ubiquitination at Lys 115
  • Modification sites at PhosphoSitePlus

Other Protein References for MAK16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAK16 Gene

Domains & Families for MAK16 Gene

Gene Families for MAK16 Gene

Protein Domains for MAK16 Gene

Suggested Antigen Peptide Sequences for MAK16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MAK16 family.
  • Belongs to the MAK16 family.
genes like me logo Genes that share domains with MAK16: view

Function for MAK16 Gene

Gene Ontology (GO) - Molecular Function for MAK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MAK16: view

Phenotypes for MAK16 Gene

GenomeRNAi human phenotypes for MAK16:
genes like me logo Genes that share phenotypes with MAK16: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MAK16 Gene

Localization for MAK16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAK16 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for MAK16 Gene COMPARTMENTS Subcellular localization image for MAK16 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for MAK16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with MAK16: view

Pathways & Interactions for MAK16 Gene

SuperPathways for MAK16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAK16 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAK16 Gene

Drugs & Compounds for MAK16 Gene

No Compound Related Data Available

Transcripts for MAK16 Gene

Unigene Clusters for MAK16 Gene

MAK16 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAK16 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - -
SP2: - -
SP3: -
SP5: -

Relevant External Links for MAK16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAK16 Gene

mRNA expression in normal human tissues for MAK16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAK16 Gene

This gene is overexpressed in Fetal ovary (14.4), Liver (13.7), Adrenal (10.5), Peripheral blood mononuclear cells (10.3), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAK16 Gene

SOURCE GeneReport for Unigene cluster for MAK16 Gene Hs.583805

genes like me logo Genes that share expression patterns with MAK16: view

Protein tissue co-expression partners for MAK16 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAK16 Gene

Orthologs for MAK16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAK16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAK16 35
  • 90.94 (n)
  • 94.97 (a)
MAK16 36
  • 96 (a)
(Canis familiaris)
Mammalia MAK16 35
  • 91.16 (n)
  • 94.63 (a)
MAK16 36
  • 95 (a)
(Mus musculus)
Mammalia Mak16 35
  • 86.6 (n)
  • 88.85 (a)
Mak16 16
Mak16 36
  • 90 (a)
(Pan troglodytes)
Mammalia MAK16 35
  • 99.33 (n)
  • 99.33 (a)
MAK16 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mak16 35
  • 86.58 (n)
  • 88.05 (a)
(Monodelphis domestica)
Mammalia MAK16 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia MAK16 36
  • 79 (a)
(Gallus gallus)
Aves MAK16 35
  • 74.89 (n)
  • 81.51 (a)
MAK16 36
  • 81 (a)
(Anolis carolinensis)
Reptilia MAK16 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mak16 35
  • 74.05 (n)
  • 81.54 (a)
MGC75652 35
African clawed frog
(Xenopus laevis)
Amphibia mak16l-prov 35
(Danio rerio)
Actinopterygii mak16 35
  • 69.82 (n)
  • 73.99 (a)
mak16l 35
mak16 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000514 35
  • 61.25 (n)
  • 64.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rbm13 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea C16A3.6 35
  • 55.97 (n)
  • 52.9 (a)
C16A3.6 36
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR349W 35
  • 53.55 (n)
  • 50.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04037g 35
  • 56.43 (n)
  • 52.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK16 35
  • 54.81 (n)
  • 51.41 (a)
MAK16 36
  • 42 (a)
MAK16 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G23280 35
  • 54.71 (n)
  • 49.28 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4373 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04150 35
  • 53.38 (n)
  • 45.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mak16 35
  • 54.3 (n)
  • 52.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
Species with no ortholog for MAK16:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAK16 Gene

Gene Tree for MAK16 (if available)
Gene Tree for MAK16 (if available)

Paralogs for MAK16 Gene

No data available for Paralogs for MAK16 Gene

Variants for MAK16 Gene

Sequence variations from dbSNP and Humsavar for MAK16 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1829189 -- 33,492,778(-) CACTA(C/T)AGTAA intron-variant
rs1829190 -- 33,492,675(-) tgcca(A/C)gaaca intron-variant
rs2037213 -- 33,484,500(+) CTTCT(G/T)GGTAT upstream-variant-2KB
rs2459509 -- 33,495,810(-) GAACT(C/T)GGGAG intron-variant
rs2459510 -- 33,495,685(-) aaaaa(A/T)TTCCC intron-variant

Variation tolerance for MAK16 Gene

Residual Variation Intolerance Score: 39.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAK16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAK16 Gene

Disorders for MAK16 Gene

Relevant External Links for MAK16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAK16: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAK16 Gene

Publications for MAK16 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. (PMID: 23891004) Stehling O. … Lill R. (Cell Metab. 2013) 67
  4. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PMID: 22678362) Stehling O. … Lill R. (Science 2012) 67
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67

Products for MAK16 Gene

Sources for MAK16 Gene

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