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Aliases & Descriptions for MAK
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.7.11.22 3 | | OTTHUMP00000016025 2 | | dJ417M14.2 1, 2 |
| | | Descriptions |
|---|
| male germ cell-associated kinase 2, 3 | | serine/threonine protein kinase MAK 2 |
|
| | Search outside databases for aliases for MAK genePrevious GC identifer: GC06M010820 |
Summaries for MAK(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for MAK: The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized. [provided by RefSeq] UniProtKB/Swiss-Prot: MAK_HUMAN, P20794Function: Could play an important function in spermatogenesisGene Wiki entry for MAK |
Genomic Location for MAK
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the MAK gene 
Entrez Gene cytogenetic band: 6p24 Ensembl cytogenetic band: 6p24.2 HGNC cytogenetic band: 6q22MAK Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M010870:
(about GC identifiers)
Start:
|
10,870,942 bp from pter |
End:
|
10,946,714 bp from pter |
Size:
|
75,773 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14
| Proteins for MAK
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MAK_HUMAN, P20794 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase MAK Size: 623 amino acids; 70581 Da
Secondary accessions: Q9NUH7Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005897.1
ENSEMBL proteins: ENSP00000313021 ENSP00000346484
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for MAK: Assays for MAK: | Protein
Domains/ Families for MAK(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P20794
ProtoNet protein and cluster: P20794 UniProtKB/Swiss-Prot: MAK_HUMAN, P20794Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamilySimilarity: Contains 1 protein kinase domain | Gene Function for MAK
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005906
Applied Biosystems Silencer® siRNAs for MAK
Sigma-Aldrich siRNA and siRNA Panels for MAK  Sigma-Aldrich shRNA Panels and shRNA for MAK  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005906                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005906                                  untagged cDNA clones in CMV expression vector (see all 2): NM_005906 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005906
UniProtKB/Swiss-Prot: MAK_HUMAN, P20794Function: Could play an important function in spermatogenesisCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.22 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Mak):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for MAK
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for MAK (Your Favorite Gene powered by Ingenuity) 
1 Interacting protein for MAK (ENSP000003130213) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for MAK(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for MAK
|
Transcripts for MAK(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005906
Sigma-Aldrich siRNA and siRNA Panels for MAK  Sigma-Aldrich shRNA Panels and shRNA for MAK  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005906 REFSEQ mRNAs for MAK gene: NM_005906.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005906               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005906                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005906                                  untagged cDNA clones in CMV expression vector (see all 2): NM_005906  Additional cDNA sequence: AF505623.1 AK097831.1 AK310329.1 AK314408.1 BC033002.1 BC039825.1 9 DOTS entries: DT.104633 DT.121397478 DT.95309194 DT.100020488 DT.121397386 DT.307271 DT.121397352 DT.40304703 DT.437232 24/57 AceView cDNA sequences (see all 57
):BX105286 BM702638 BC033002 BX955062 NM_005906 AF505623 BU729587 BQ639003 AK097831 BC039825 BM709886 BU733728 BM713609 AI015438 AI200150 BM978645 CK300055 BM704130 BP351687 BX645973 BG718521 AI868638 BU736566 BU730025
highest scoring ESTs for MAK:AA058851 AA812897 AF505623 AK097831 BC033002 BC039825 BG718521 BI458728 BI832042 CD299900 Unigene Cluster for MAK: Male germ cell-associated kinase Hs.446125 [show with all ESTs]Unigene Representative Sequence: NM_005906
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAK (see all 7
)
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for MAK
2 Ensembl transcripts including schematic representations: ENST00000313243
ENST00000354489
|
Expression for MAK
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MAK expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MAK
1 / 2 / 3 5 probe-sets matching MAK gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTGCTGACCA
SOURCE GeneReport for Unigene cluster: Hs.446125 UniProtKB/Swiss-Prot: MAK_HUMAN, P20794Tissue specificity: Expressed mainly in testicular cells at and after meiosis |
Orthologs for MAK
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MAK gene from 5/16 species (see all 16
)
About this table Species with no ortholog for MAK
ENSEMBL Gene Tree for MAK | Paralogs for MAK(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for MAK gene
- ICK2
|
SNPs/Variants for MAK(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for MAK (up to first 250kb)
|
Disorders & Mutations for MAK
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 154235
|
Medical News for MAK(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications for MAK (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for MAK gene (see all 13
):- Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells. (PubMed id 16951154)1, 2, 3 Ma A.H....Kung H.J. (2006)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis. (PubMed id 2183027)3, 4 Matsushime H.... Shibuya M. (1990)
- Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. (PubMed id 16954377)1, 3 Fu Z....Sturgill T.W. (2006)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)4 Greenman C.... Stratton M.R. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells. (PubMed id 12084720)3 Xia L.... Kung H.J. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Mouse Mak gene for male germ cell-associated kinase maps to chromosome 13. (PubMed id 8188277)3 Taketo M....Seldin M.F. (1994)
- Characterization and expression analysis of the murine rck gene: a protein kinase with a potential function in sensory cells. (PubMed id 8359591)3 Bladt F. and Birchmeier C. (1993)
|
Search for MAK
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MAK
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MAK
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAK(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for MAK(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for MAK:

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Incremental update: 13 Oct 2009
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