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Aliases for MAGT1 Gene

Aliases for MAGT1 Gene

  • Magnesium Transporter 1 2 3 5
  • Implantation-Associated Protein 3 4
  • IAP 3 4
  • Oligosaccharyltransferase 3 Homolog B (S. Cerevisiae) 2
  • Oligosaccharyltransferase 3 Homolog B 3
  • BA217H1.1 3
  • PRO0756 3
  • MRX95 3
  • OST3B 3
  • MagT1 4
  • XMEN 3
  • IAG2 4

External Ids for MAGT1 Gene

Previous GeneCards Identifiers for MAGT1 Gene

  • GC0XM076968
  • GC0XM077081
  • GC0XM070668

Summaries for MAGT1 Gene

Entrez Gene Summary for MAGT1 Gene

  • This gene encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jan 2010]

GeneCards Summary for MAGT1 Gene

MAGT1 (Magnesium Transporter 1) is a Protein Coding gene. Diseases associated with MAGT1 include Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia and X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia. Among its related pathways are Transport to the Golgi and subsequent modification and Miscellaneous transport and binding events. GO annotations related to this gene include magnesium ion transmembrane transporter activity. An important paralog of this gene is TUSC3.

UniProtKB/Swiss-Prot for MAGT1 Gene

  • May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involved in Mg(2+) transport in epithelial cells.

Gene Wiki entry for MAGT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGT1 Gene

Genomics for MAGT1 Gene

Regulatory Elements for MAGT1 Gene

Enhancers for MAGT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAGT1 on UCSC Golden Path with GeneCards custom track

Promoters for MAGT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAGT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAGT1 Gene

77,826,364 bp from pter
77,895,593 bp from pter
69,230 bases
Minus strand

Genomic View for MAGT1 Gene

Genes around MAGT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGT1 Gene

Proteins for MAGT1 Gene

  • Protein details for MAGT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Magnesium transporter protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RAR4
    • D3DTE3
    • Q53G00
    • Q6P577
    • Q8NBN6

    Protein attributes for MAGT1 Gene

    335 amino acids
    Molecular mass:
    38037 Da
    Quaternary structure:
    • Weakly associates with the oligosaccharyl transferase (OST) complex which contains at least RPN1/ribophorin I, RPN2/ribophorin II, OST48, DAD1, and either STT3A or STT3B.

    Alternative splice isoforms for MAGT1 Gene


neXtProt entry for MAGT1 Gene

Proteomics data for MAGT1 Gene at MOPED

Post-translational modifications for MAGT1 Gene

Other Protein References for MAGT1 Gene

Antibody Products

  • Abcam antibodies for MAGT1

No data available for DME Specific Peptides for MAGT1 Gene

Domains & Families for MAGT1 Gene

Suggested Antigen Peptide Sequences for MAGT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Belongs to the OST3/OST6 family.
  • Contains 1 thioredoxin domain.
  • Belongs to the OST3/OST6 family.
genes like me logo Genes that share domains with MAGT1: view

Function for MAGT1 Gene

Molecular function for MAGT1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involved in Mg(2+) transport in epithelial cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated by low extracellular Mg(2+).
genes like me logo Genes that share phenotypes with MAGT1: view

Human Phenotype Ontology for MAGT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for MAGT1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGT1 Gene

Localization for MAGT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGT1 Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MAGT1 Gene COMPARTMENTS Subcellular localization image for MAGT1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MAGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008250 oligosaccharyltransferase complex IDA 15835887
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MAGT1: view

Pathways & Interactions for MAGT1 Gene

genes like me logo Genes that share pathways with MAGT1: view

Gene Ontology (GO) - Biological Process for MAGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006487 protein N-linked glycosylation NAS 18455129
GO:0015693 magnesium ion transport IMP 19717468
GO:0043687 post-translational protein modification TAS --
GO:0045454 cell redox homeostasis IEA --
GO:0050890 cognition IMP 18455129
genes like me logo Genes that share ontologies with MAGT1: view

No data available for SIGNOR curated interactions for MAGT1 Gene

Drugs & Compounds for MAGT1 Gene

No Compound Related Data Available

Transcripts for MAGT1 Gene

Unigene Clusters for MAGT1 Gene

Magnesium transporter 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGT1 Gene

No ASD Table

Relevant External Links for MAGT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGT1 Gene

mRNA expression in normal human tissues for MAGT1 Gene

Protein differential expression in normal tissues from HIPED for MAGT1 Gene

This gene is overexpressed in Nasal epithelium (41.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGT1 Gene

SOURCE GeneReport for Unigene cluster for MAGT1 Gene Hs.323562

mRNA Expression by UniProt/SwissProt for MAGT1 Gene

Tissue specificity: Ubiquitous. Expressed at very low levels in brain, lung and kidney.
genes like me logo Genes that share expression patterns with MAGT1: view

Protein tissue co-expression partners for MAGT1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAGT1 Gene

Orthologs for MAGT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAGT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAGT1 35
  • 94.43 (n)
  • 97.31 (a)
MAGT1 36
  • 88 (a)
(Canis familiaris)
Mammalia MAGT1 35
  • 92.46 (n)
  • 93.46 (a)
MAGT1 36
  • 83 (a)
(Mus musculus)
Mammalia Magt1 35
  • 89.16 (n)
  • 90.71 (a)
Magt1 16
Magt1 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Magt1 35
  • 89.09 (n)
  • 93.09 (a)
(Monodelphis domestica)
Mammalia MAGT1 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
-- 36
  • 85 (a)
(Pan troglodytes)
Mammalia MAGT1 36
  • 99 (a)
(Gallus gallus)
Aves MAGT1 35
  • 80.91 (n)
  • 89.78 (a)
MAGT1 36
  • 89 (a)
(Anolis carolinensis)
Reptilia MAGT1 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia magt1 35
  • 76.45 (n)
  • 87.38 (a)
Str.15570 35
(Danio rerio)
Actinopterygii magt1 35
  • 75.03 (n)
  • 82.76 (a)
wufc49b02 35
magt1 36
  • 80 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9275 35
fruit fly
(Drosophila melanogaster)
Insecta CG7830 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea ZK686.3 36
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OST3 36
  • 19 (a)
OST3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10969 36
  • 46 (a)
Species with no ortholog for MAGT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAGT1 Gene

Gene Tree for MAGT1 (if available)
Gene Tree for MAGT1 (if available)

Paralogs for MAGT1 Gene

Paralogs for MAGT1 Gene

(1) SIMAP similar genes for MAGT1 Gene using alignment to 2 proteins: Pseudogenes for MAGT1 Gene

genes like me logo Genes that share paralogs with MAGT1: view

Variants for MAGT1 Gene

Sequence variations from dbSNP and Humsavar for MAGT1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs145245774 - 77,830,865(+) ATAAT(A/C)CAACA reference, missense
rs13994 -- 77,826,498(+) CCAGA(A/G)AAGTA utr-variant-3-prime
rs1537892 -- 77,857,912(+) CTAAA(A/G)CAGCA intron-variant
rs2027209 -- 77,891,585(+) ATAGA(A/T)AATGA intron-variant
rs4826198 -- 77,849,367(+) gagcc(A/G)ccgca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGT1 Gene

Variant ID Type Subtype PubMed ID
nsv511668 CNV Loss 21212237
esv2740244 CNV Deletion 23290073
nsv512679 CNV Loss 21212237
esv2661329 CNV Deletion 23128226
dgv202e180 CNV Loss 20482838
nsv821080 CNV Deletion 20802225
nsv829381 CNV Loss 20364138
esv21463 CNV Gain+Loss 19812545
esv1784785 CNV Deletion 17803354

Variation tolerance for MAGT1 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGT1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGT1 Gene

Disorders for MAGT1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MAGT1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MAGT1 in MalaCards View complete list of genes associated with diseases


  • Immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection and neoplasia (XMEN) [MIM:300853]: A disease characterized by CD4 lymphopenia, severe chronic viral infections, and defective T-lymphocyte activation. {ECO:0000269 PubMed:21796205}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MAGT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAGT1: view

No data available for Genatlas for MAGT1 Gene

Publications for MAGT1 Gene

  1. Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties. (PMID: 15804357) Goytain A. … Quamme G.A. (BMC Genomics 2005) 2 3 4 67
  2. Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins. (PMID: 25135935) Cherepanova N.A. … Gilmore R. (J. Cell Biol. 2014) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for MAGT1 Gene

Sources for MAGT1 Gene