MAGT1 Gene
protein-coding GIFtS: 52
GCID: GC0XM077081
|
|
magnesium transporter 1
| |
Aliases
for MAGT1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Magnesium Transporter 11 2 | | XMEN2 | | IAP1 2 3 5 | | BA217H1.11 | | MRX951 2 | | Magnesium Transporter Protein 12 | | OST3B1 2 | | Oligosaccharyltransferase 3 Homolog B2 | | Implantation-Associated Protein2 3 | | IAG23 | | DKFZp564K1421 | | MagT13 | | PRO07562 | | |
Export aliases for MAGT1 gene to outside databasesPrevious GC identifers: GC0XM076968 GC0XM070668 |
Summaries
for MAGT1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGT1:
This gene encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein alsoassociates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this genecause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites,one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29.(provided by RefSeq, Jan 2010)
UniProtKB/Swiss-Prot: MAGT1_HUMAN, Q9H0U3Function: May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involvedin Mg(2+) transport in epithelial cells
Gene Wiki entry for MAGT1 (RP11-217H1.1)
|
Genomic Views
for MAGT1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGT1 gene promoter:
N-Myc POU2F1 POU2F1a TGIF NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGT1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGT1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq21.1 Ensembl cytogenetic band: Xq21.1 HGNC cytogenetic band: Xq21.1MAGT1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM077081: view genomic region
(about GC identifiers)
Start:
|
77,081,861 bp from pter |
End:
|
77,151,090 bp from pter |
Size:
|
69,230 bases |
Orientation:
|
minus strand |
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Proteins
for MAGT1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGT1_HUMAN, Q9H0U3 (See
protein sequence)Recommended Name: Magnesium transporter protein 1 precursor Size: 335 amino acids; 38037 Da
Subunit: Weakly associates with the oligosaccharyl transferase (OST) complex which contains at least RPN1/ribophorin I,RPN2/ribophorin II, OST48, DAD1, and either STT3A or STT3B (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membraneprotein (By similarity)
Secondary accessions: B2RAR4 D3DTE3 Q53G00 Q8NBN6Explore the universe of human proteins at neXtProt for MAGT1: NX_Q9H0U3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0U3
MAGT1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115497.4
ENSEMBL proteins: ENSP00000354649 ENSP00000362433
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MAGT1 for ontologies About GeneDecksing
MAGT1 Antibody Products:
Assay Products for MAGT1: |
Protein
Domains /
Families
for MAGT1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGT1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H0U3ProtoNet protein and cluster: Q9H0U3 1 Blocks protein family: IPB006844 OST3/OST6
UniProtKB/Swiss-Prot: MAGT1_HUMAN, Q9H0U3Similarity: Belongs to the OST3/OST6 familySimilarity: Contains 1 thioredoxin domain |
Function
for MAGT1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAGT1_HUMAN, Q9H0U3Function: May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involvedin Mg(2+) transport in epithelial cellsInduction: Up-regulated by low extracellular Mg(2+)
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGT1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015095 | magnesium ion transmembrane transporter activity |
IMP | 19717468 |
MAGT1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for MAGT1:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Magt1):
MAGT1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MAGT1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGT1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/17 Interacting proteins for MAGT1 (Q9H0U33 ENSP000003546494) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
MAGT1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAGT1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGT1
Search CenterWatch for drugs/clinical trials and news about MAGT1
|
Transcripts
for MAGT1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGT1 gene: NM_032121.5 Unigene Cluster for MAGT1: Magnesium transporter 1 Hs.323562 [show with all ESTs]Unigene Representative Sequence: NM_0321213 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000358075(uc004fof.3 uc004fog.4) ENST00000476168 ENST00000373336(uc004ect.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGT1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGT1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AF130104.2 AK027632.1 AK075394.1 AK172735.1 AK223131.1 AK294943.1 AK296743.1 AK314309.1 AL136636.1 AY358691.1 BC018447.1 BC041014.1 BC050657.1 BC060842.1 BC063037.1 DQ000004.1 11 DOTS entries: DT.95245342 DT.95129638 DT.100753133 DT.121292715 DT.95129646 DT.100826606 DT.100826609 DT.121292714 DT.91639236 DT.100826607 DT.95129637 24/289 AceView cDNA sequences (see all 289): AI357366 BX956360 T39360 AV650760 BC018447 BM876579 AA196715 AW875790 BU686503 AA046836 BF445892 BQ416644 AI873864 BM828564 AI215697 AI436234 BP344320 AI687959 AA807111 AA508855 BM876318 CR599925 BU072446 BQ025107
GeneLoc Exon Structure
|
Expression
for MAGT1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACATTGACA
About this image
See MAGT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGT1
SOURCE GeneReport for Unigene cluster: Hs.323562
UniProtKB/Swiss-Prot: MAGT1_HUMAN, Q9H0U3Tissue specificity: Ubiquitous. Expressed at very low levels in brain, lung and kidney
SABiosciences Custom PCR Arrays for MAGT1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGT1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAGT1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGT1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGT1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGT1 |
Orthologs
for MAGT1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for MAGT1 gene from 7/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
MAGT11 |
magnesium transporter 1 |
81.16(n)
90.06(a) |
|
422332 NM_001006435.1 NP_001006435.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MAGT16 |
-- |
91(a) |
1 ↔ 1 |
GL343420.1(770713-778079) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.155702 |
Transcribed sequence with moderate similarity to protein more |
78.39(n) |
|
BX715350.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc49b022 |
wufc49b02 |
78.66(n) |
|
324944 BC046002.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG78306 |
-- |
50(a) |
1 → many |
2L(8306696-8308192) |
worm
(Caenorhabditis elegans) |
Secernentea |
ZK686.36 |
Uncharacterized protein ZK686.3 |
41(a) |
1 → many |
III(7767506-7769000) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
OST3(YOR085W)4
OST31 |
Gamma subunit of the oligosaccharyltransferase complex more4
Ost3p1 |
41.56(n)1
25.65(a)1 |
|
15(482033-483085)4
8542521, 4 NP_014728.11, 4 |
ENSEMBL Gene Tree for MAGT1 (if available)
TreeFam Gene Tree for MAGT1 (if available) |
Paralogs
for MAGT1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGT1 gene
- TUSC32
1 SIMAP similar gene for MAGT1 using alignment to 2 protein entries: MAGT1_HUMAN (see all proteins):TUSC3
MAGT1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MAGT1
PGOHUM00000243968
|
Genomic Variants
for MAGT1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGT1 (77081861 - 77151090 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for MAGT1
2 CNVs: 96773 67993
9 Indels: 83608 96771 96774 83607 96772 83606 29354 96775 96776
Human Gene Mutation Database (HGMD): MAGT1
Locus Specific Mutation Databases (LSDB): MAGT1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGT1 |
|
Disorders
/ Diseases
for MAGT1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGT1 for disorders About GeneDecksing
OMIM gene information: 300715
OMIM disorders: 300716
UniProtKB/Swiss-Prot: MAGT1_HUMAN, Q9H0U3
Defects in MAGT1 are the cause of mental retardation X-linked type 95 (MRX95) [MIM:300716]. Mental retardationis characterized by significantly sub-average general intellectual functioning associated with impairments inadaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linkedmental retardation which also present with associated physical, neurological and/or psychiatric manifestations,intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation Defects in MAGT1 are the cause of immunodeficiency X-linked with magnesium defect Epstein-Barr virus infectionand neoplasia (XMEN) [MIM:300853]. XMEN is a disease characterized by CD4 lymphopenia, severe chronic viralinfections, and defective T-lymphocyte activation
6  diseases for MAGT1: About MalaCardsmental retardation, x-linked lymphopenia t lymphocyte deficiency immunodeficiency
prostate cancer prostatitis
Export disorders for MAGT1 gene to outside databases
|
Publications
for MAGT1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGT1 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with MAGT1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties. (PubMed id 15804357)1, 2, 3 Goytain A. and Quamme G.A. (2005)
- Mammalian MagT1 and TUSC3 are required for cellular m agnesium uptake and vertebrate embryonic development. (PubMed id 19717468)1, 2 Zhou H. and Clapham D.E. (2009)
- Oligosaccharyltransferase-subunit mutations in nonsyndromic mental retardation. (PubMed id 18455129)1, 2 Molinari F.... Colleaux L. (2008)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PubMed id 12887896)1, 2 Kelleher D.J.... Gilmore R. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for MAGT1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGT1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGT1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGT1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAGT1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MAGT1 gene:
Search GeneIP for patents involving MAGT1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGT1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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