Aliases for MAGT1 Gene
External Ids for MAGT1 Gene
This gene encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jan 2010]
GeneCards Summary for MAGT1 Gene
MAGT1 (Magnesium Transporter 1) is a Protein Coding gene. Diseases associated with MAGT1 include immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection and neoplasia and non-syndromic x-linked intellectual disability. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include magnesium ion transmembrane transporter activity. An important paralog of this gene is TUSC3.
UniProtKB/Swiss-Prot for MAGT1 Gene
May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involved in Mg(2+) transport in epithelial cells.