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Aliases for MAGOHB Gene

Aliases for MAGOHB Gene

  • Mago Homolog B, Exon Junction Complex Core Component 2 3 5
  • Mago-Nashi Homolog B (Drosophila) 2
  • Protein Mago Nashi Homolog 2 3
  • Mago-Nashi Homolog B 3
  • MAGOH2 4
  • Magoh 3
  • MGN2 3
  • Mago 3

External Ids for MAGOHB Gene

Previous GeneCards Identifiers for MAGOHB Gene

  • GC12M010652
  • GC12M010756
  • GC12M010485
  • GC12M010653
  • GC12M010821
  • GC12M011023
  • GC12M011327
  • GC12M011545

Summaries for MAGOHB Gene

GeneCards Summary for MAGOHB Gene

MAGOHB (Mago Homolog B, Exon Junction Complex Core Component) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Formation of HIV elongation complex in the absence of HIV Tat. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is MAGOH.

UniProtKB/Swiss-Prot for MAGOHB Gene

  • Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.

Additional gene information for MAGOHB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGOHB Gene

Genomics for MAGOHB Gene

Regulatory Elements for MAGOHB Gene

Enhancers for MAGOHB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H010715 1.4 ENCODE dbSUPER 22.5 -106.5 -106472 8.8 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FOS KLRA1P TAS2R20 TAS2R43 TAS2R31 MAGOHB ENSG00000256682 LINC02366 SLC25A39P2 HNRNPABP1 LOC100419929
GH12H010391 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +218.8 218840 7.4 FOXA2 ARID4B FEZF1 ATF7 RUNX3 DEK JUNB TSHZ1 ZNF662 KAT8 KLRA1P KLRK1 TAS2R20 KLRC3 KLRC4 KLRC2 LOC101928100 TAS2R31 TAS2R43 MAGOHB
GH12H010672 0.8 Ensembl ENCODE 20.9 -59.1 -59051 1.2 ZNF610 ZNF585B ZBTB33 ATF2 CREM ZNF18 MAGOHB TAS2R14 TAS2R15P KLRA1P ENSG00000256274 TAS2R31 ENSG00000255958 GABARAPL1 KLRK1 STYK1
GH12H010673 1 ENCODE 15.1 -60.5 -60520 1.5 SIN3A ZNF2 TCF12 GLIS2 ZNF143 ZNF207 RUNX3 SP3 YY2 REST KLRA1P MAGOHB TAS2R20 TAS2R14 LOC101928100 STYK1 GC12P010619
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAGOHB on UCSC Golden Path with GeneCards custom track

Promoters for MAGOHB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for MAGOHB Gene

Genomic Locations for MAGOHB Gene
9,859 bases
Minus strand

Genomic View for MAGOHB Gene

Genes around MAGOHB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGOHB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGOHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGOHB Gene

Proteins for MAGOHB Gene

  • Protein details for MAGOHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein mago nashi homolog 2
    Protein Accession:

    Protein attributes for MAGOHB Gene

    148 amino acids
    Molecular mass:
    17276 Da
    Quaternary structure:
    • Interacts with RBM8A and is part of the exon junction complex (EJC).

neXtProt entry for MAGOHB Gene

Post-translational modifications for MAGOHB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGOHB Gene

Domains & Families for MAGOHB Gene

Gene Families for MAGOHB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGOHB Gene


Suggested Antigen Peptide Sequences for MAGOHB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mago nashi family.
  • Belongs to the mago nashi family.
genes like me logo Genes that share domains with MAGOHB: view

Function for MAGOHB Gene

Molecular function for MAGOHB Gene

UniProtKB/Swiss-Prot Function:
Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.

Gene Ontology (GO) - Molecular Function for MAGOHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,IEA 22681889
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MAGOHB: view
genes like me logo Genes that share phenotypes with MAGOHB: view

Animal Model Products

CRISPR Products

miRNA for MAGOHB Gene

miRTarBase miRNAs that target MAGOHB

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGOHB Gene

Localization for MAGOHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGOHB Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGOHB gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MAGOHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0035145 exon-exon junction complex IDA 23917022
GO:0043025 neuronal cell body IEA --
GO:0071013 catalytic step 2 spliceosome IBA --
genes like me logo Genes that share ontologies with MAGOHB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MAGOHB Gene

Pathways & Interactions for MAGOHB Gene

genes like me logo Genes that share pathways with MAGOHB: view

Gene Ontology (GO) - Biological Process for MAGOHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing IEA --
GO:0006405 RNA export from nucleus TAS --
genes like me logo Genes that share ontologies with MAGOHB: view

No data available for SIGNOR curated interactions for MAGOHB Gene

Drugs & Compounds for MAGOHB Gene

No Compound Related Data Available

Transcripts for MAGOHB Gene

Unigene Clusters for MAGOHB Gene

Mago-nashi homolog B (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGOHB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - - - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for MAGOHB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGOHB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGOHB Gene

Protein differential expression in normal tissues from HIPED for MAGOHB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.5) and Nasal epithelium (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAGOHB Gene

Protein tissue co-expression partners for MAGOHB Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGOHB Gene:


SOURCE GeneReport for Unigene cluster for MAGOHB Gene:


mRNA Expression by UniProt/SwissProt for MAGOHB Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for MAGOHB Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MAGOHB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGOHB Gene

Orthologs for MAGOHB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAGOHB Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MAGOHB 34
  • 100 (a)
(Pan troglodytes)
Mammalia MAGOHB 33 34
  • 99.55 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 99 (a)
-- 34
  • 98 (a)
(Bos Taurus)
Mammalia MAGOHB 33 34
  • 94.82 (n)
(Mus musculus)
Mammalia Magohb 33 16 34
  • 91.22 (n)
(Rattus norvegicus)
Mammalia Magohb 33
  • 90.54 (n)
(Gallus gallus)
Aves MAGOH 34
  • 99 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia magoh 33
  • 83.33 (n)
(Danio rerio)
Actinopterygii magoh 33 34
  • 78.62 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010755 33
  • 72.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta mago 33 34
  • 70.57 (n)
(Caenorhabditis elegans)
Secernentea mag-1 33 34
  • 65.75 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MAGO 33
  • 65.52 (n)
(Oryza sativa)
Liliopsida Os12g0287200 33
  • 65.98 (n)
Os.12841 33
bread mold
(Neurospora crassa)
Ascomycetes NCU04405 33
  • 62.61 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mnh1 33
  • 57.87 (n)
Species where no ortholog for MAGOHB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAGOHB Gene

Gene Tree for MAGOHB (if available)
Gene Tree for MAGOHB (if available)

Paralogs for MAGOHB Gene

Paralogs for MAGOHB Gene

(1) SIMAP similar genes for MAGOHB Gene using alignment to 6 proteins: Pseudogenes for MAGOHB Gene

genes like me logo Genes that share paralogs with MAGOHB: view

Variants for MAGOHB Gene

Sequence variations from dbSNP and Humsavar for MAGOHB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_036431 A breast cancer sample
rs1000139915 -- 10,615,058(+) CAGCA(C/G)TTTGG upstream-variant-2KB
rs1000426790 -- 10,614,576(+) TCACA(A/G)AATTC upstream-variant-2KB
rs1000835038 -- 10,610,146(+) TTTTT(C/T)CCTCT intron-variant
rs1000990070 -- 10,610,454(+) TGGAT(G/T)CAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGOHB Gene

Variant ID Type Subtype PubMed ID
nsv516351 CNV loss 19592680
nsv832329 CNV gain 17160897

Variation tolerance for MAGOHB Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGOHB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGOHB Gene

Disorders for MAGOHB Gene

Relevant External Links for MAGOHB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAGOHB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGOHB Gene

Publications for MAGOHB Gene

  1. Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. (PMID: 23917022) Singh KK … Gehring NH (RNA biology 2013) 2 3 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 60

Products for MAGOHB Gene

Sources for MAGOHB Gene

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