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MAGOHB Gene

protein-coding   GIFtS: 49

GC12M010652
mago-nashi homolog B (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ10292 1, 2
MAGOH2 3
MGN2 1, 2
mago 2
magoh 2
Descriptions
mago-nashi homolog 2 2
mago-nashi homolog B 2
mago-nashi homolog B (Drosophila) 2
External Ids
HGNC: 255041
Entrez Gene: 551102
UniProtKB: Q96A723
Ensembl: ENSG000001111967
Search outside databases for aliases for MAGOHB gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: MGN2_HUMAN, Q96A72
Function: Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway (By
similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2

MAGOHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010652:     (about GC identifiers)

Start:
10,648,061 bp from pter
End:
10,657,460 bp from pter
Size:
9,400 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000012.10  NT_009714.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MGN2_HUMAN, Q96A72 (See protein sequence)
Recommended Name: Protein mago nashi homolog 2  
Size: 148 amino acids; 17276 Da
Subunit: Interacts with RBM8A and is part of the exon junction complex (EJC) containing NCBP1,
NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2 and THOC4. Remains associated with the mRNA after
its export to the cytoplasm and require translation of the mRNA for removal (By similarity)
Subcellular location: Nucleus (By similarity)

REFSEQ proteins: NP_060518.1  

ENSEMBL proteins: 
ENSP00000371305 ENSP00000319240 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Mago nashi homolog 2)
Human Recombinant Proteins from Abnova (FLJ10292)
              OriGene Purified Recombinant Human Protein: MAGOHB 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
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Antibodies for MAGOHB: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (Mago nashi homolog 2), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (FLJ10292)
Novus Biologicals Antibody for MAGOHB

Assays for MAGOHB: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR004023 Mago_nashi


   GeneDecks  MAGOHB for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q96A72

ProtoNet protein and cluster: Q96A72

1 Blocks protein family: IPB004023 Mago nashi protein

UniProtKB/Swiss-Prot: MGN2_HUMAN, Q96A72
Similarity: Belongs to the mago nashi family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (MAGOHB)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018048

              Applied Biosystems Silencer® siRNAs for MAGOHB

              Sigma-Aldrich siRNA for MAGOHB  
                     Sigma-Aldrich shRNA for MAGOHB  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for MAGOHB
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018048
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018048
                                 untagged cDNA clone in CMV expression vector: NM_018048 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_018048

UniProtKB/Swiss-Prot: MGN2_HUMAN, Q96A72
Function: Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway (By
similarity)

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003723 RNA binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  MAGOHB 


5/6 Interacting proteins for MAGOHB (ENSP000003192403 Q96A722) via UniProtKB, MINT, and/or STRING (see all 6 )
InteractantInteraction Details
GeneCardExternal ID(s)
RBM8AQ9Y5S92STRING (score=.996) MINT-68487
HMG20AQ9NP662MINT-66920
YWHAGP619812MINT-50835
EIF4A3ENSP000002693493STRING (score=.995)
RBMX2ENSP000002570203STRING (score=.944)
About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006397 mRNA processing IEA--
GO:0006810 transport IEA--
GO:0008380 RNA splicing IEA--
GO:0051028 mRNA transport IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGOHB

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (MAGOHB)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018048

              Sigma-Aldrich siRNA for MAGOHB  
                     Sigma-Aldrich shRNA for MAGOHB  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_018048  

REFSEQ mRNAs for MAGOHB gene: 

NM_018048.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_018048  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018048
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018048
                                 untagged cDNA clone in CMV expression vector: NM_018048 

Additional cDNA sequence: 

AF165518.1 AK001154.1 AK022720.1 BC010905.1 CR604359.1 

14 DOTS entries:

DT.110126  DT.92439363  DT.92439367  DT.100680654  DT.308826  DT.91912193  DT.100788082  DT.99932203 
DT.100723817  DT.120759585  DT.99936630  DT.100788085  DT.95376404  DT.95300342 

24/127 AceView cDNA sequences (see all 127 ):

BX335457 CR604359 CA413908 BX283230 BE881038 NM_018048 AK022720 BF185893 
BG531258 AW999759 BG532957 CD723604 BG533740 BU540128 BE887551 AA442090 
BF207705 AK096106 BG493927 AL709293 BU933036 AW292923 BU509193 BC010905 

Unigene Cluster for MAGOHB:

Mago-nashi homolog B (Drosophila)
Hs.104650  [show with all ESTs]
Unigene Representative Sequence: NM_018048


GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAGOHB (see all 6 )

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1:                    -     -                 -     -     -     -     -               
SP2:                    -     -                 -                                       
SP3:              -     -     -                 -                                       
SP4:                          -                 -                                       
SP5:                                            -                                       

About this scheme

ECgene alternative splicing isoforms for MAGOHB

2 Ensembl transcripts including schematic representations:
ENST00000381881  ENST00000320756  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAGOHB expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for MAGOHB

1 / 2

6 probe-sets matching MAGOHB gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

42517_at2 U95-B 1 1.00 1.00 0.44 0.80 -- -- -- -- --
54889_at2 U95-C 4 1.00 0.88 0.79 1.21 -- -- -- -- --

218894_s_at2 U133-A 2 1.00 0.82 -- -- -- -- -- -- --

222776_at2 U133-B 1 0.82 1.00 -- -- -- -- -- -- --

218894_s_at2 U133Plus2 2 1.00 0.82 -- -- -- -- -- -- --

222776_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
GeneDecks  MAGOHB for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GGTTGGACAG

SOURCE GeneReport for Unigene cluster: Hs.104650

UniProtKB/Swiss-Prot: MGN2_HUMAN, Q96A72
Tissue specificity: Ubiquitous

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for MAGOHB gene from 5/12 species (see all 12 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC6082201   -- similar to mago-nashi homolog 94.82(n)
99.32(a)
608220  XM_845259.1  XP_850352.1 
chimpanzee
(Pan troglodytes)
MAGOHB1   -- mago-nashi homolog B (Drosophila) 99.32(n)
99.32(a)
465288  XM_520743.2  XP_520743.2 
cow
(Bos taurus)
MAGOHB1   -- mago-nashi homolog B (Drosophila) 94.59(n)
99.32(a)
541013  NM_001076252.1  NP_001069720.1 
rat
(Rattus norvegicus)
LOC6903031   -- similar to mago-nashi homolog 90.77(n)
99.32(a)
690303  XM_001074029.1  XP_001074029.1 
mouse
(Mus musculus)
Magohb1   -- mago-nashi homolog B (Drosophila) 91.55(n)
98.63(a)
66441  NM_025564.2  NP_079840.1 
About this table        Species with no ortholog for MAGOHB

ENSEMBL Gene Tree for MAGOHB
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for MAGOHB gene
MAGOH2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/120 NCBI SNPs in MAGOHB are shown (see all 120 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 115)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs10543961,2
A,C,F,H,O10648122(-) TAGATT/ATTTAT 1 -- ut318Minor allele frequency- A:0.25EA EU WA NA 2036
rs22193831,2
A,C,F,H,O10658065(-) GCTACC/TAAAAG 1 -- ng3112Minor allele frequency- T:0.21NS EU EA WA NA 666
rs99889291,2
A,C,F,H10649795(+) AGGATA/GTATCT 1 -- ut31 ese37Minor allele frequency- G:0.35NA EU EA WA 560
rs64883121,2
A,C,F,H10658318(+) GGTGGT/AGAGAA 1 -- ng31 trp36Minor allele frequency- A:0.12NA EU EA 422
rs47635621,2
A,C,F,H10648792(+) GGCTAT/CCTAAA 1 -- ut3111Minor allele frequency- C:0.18NA EU EA WA 980
rs79658031,2
A,C,F,H10658097(+) ACTTAA/CGATAC 1 -- ng3112Minor allele frequency- C:0.15NS NA EU EA WA 662
rs107723351,2
A,C,F,H10657511(+) CCTGCC/AGTGCA 1 -- ng314Minor allele frequency- A:0.21EU EA WA 404
rs107723321,2
A,C,F,H10647879(+) ACCAAC/TGAAAT 1 -- ng517Minor allele frequency- T:0.18EU EA WA NA 560
rs47632091,2
A,C,F,H10649601(+) TGCTTG/ATAACT 1 -- ut31 ese37Minor allele frequency- A:0.20NA EU EA WA 554
rs73162371,2
A,C,F,H10658147(+) ATTAAG/ATTGGG 1 -- ng317Minor allele frequency- A:0.21NA EU EA WA 560
About this table

HapMap Linkage Disequilibrium images for MAGOHB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/16 PubMed articles for MAGOHB gene (see all 16 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55110 HGNC: 25504 AceView: FLJ10292 Ensembl:ENSG00000111196 euGenes: HUgn55110
ECgene: MAGOHB H-InvDB: MAGOHB
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for MAGOHB:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for MAGOHB-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for MAGOHB Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for MAGOHB Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

 Recombinant Proteins (FLJ10292)
 Antibodies (FLJ10292)
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 Recombinant Proteins
(Mago nashi homolog 2)
 Antibodies (Mago nashi homolog 2)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for MAGOHB




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for MAGOHB

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