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Aliases for MAGOHB Gene

Aliases for MAGOHB Gene

  • Mago Homolog B, Exon Junction Complex Core Component 2 3 5
  • Mago-Nashi Homolog B (Drosophila) 2
  • Protein Mago Nashi Homolog 2 3
  • Mago-Nashi Homolog B 3
  • MAGOH2 4
  • Magoh 3
  • MGN2 3
  • Mago 3

External Ids for MAGOHB Gene

Previous GeneCards Identifiers for MAGOHB Gene

  • GC12M010652
  • GC12M010756
  • GC12M010485
  • GC12M010653
  • GC12M010821
  • GC12M011023

Summaries for MAGOHB Gene

GeneCards Summary for MAGOHB Gene

MAGOHB (Mago Homolog B, Exon Junction Complex Core Component) is a Protein Coding gene. Among its related pathways are Transport of Mature Transcript to Cytoplasm and mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is MAGOH.

UniProtKB/Swiss-Prot for MAGOHB Gene

  • Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGOHB Gene

Genomics for MAGOHB Gene

Regulatory Elements for MAGOHB Gene

Enhancers for MAGOHB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F010384 1.4 FANTOM5 Ensembl ENCODE 23.6 +226.2 226185 5.1 TBP PKNOX1 FEZF1 BMI1 ZEB1 GTF3C2 CBX5 ETV6 FOS CREM KLRA1P MAGOHB TAS2R43 KLRC3 DDX12P TAS2R14 LOC101928100 KLRC4 TAS2R20 KLRC4-KLRK1
GH12F010672 0.8 Ensembl ENCODE 20.9 -59.1 -59051 1.2 ZNF610 ZNF585B ZBTB33 CREM ZNF18 MAGOHB TAS2R14 TAS2R64P TAS2R15P KLRA1P TAS2R31 TAS2R19 GABARAPL1 ENSG00000255958 KLRK1
GH12F010673 1 ENCODE 15.1 -60.5 -60520 1.5 SIN3A ZNF2 GLIS2 ZNF143 SP3 YY2 REST MAFF SP7 CTCF KLRA1P MAGOHB TAS2R20 TAS2R14 TAS2R31 TAS2R64P TAS2R43 LOC101928100 STYK1 GC12P010619
GH12F010715 1.1 ENCODE 11.1 -106.5 -106472 8.8 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF548 KLRA1P LOC101928162 SLC25A39P2 HNRNPABP1 LOC100419929 TAS2R43 TAS2R20 TAS2R50 TAS2R14 ENSG00000256981
GH12F011169 1.1 ENCODE 9.9 -557.8 -557819 3.0 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 LINC01252 TAS2R64P PRR4 TAS2R15P TAS2R14 KLRA1P TAS2R31 TAS2R19 MAGOHB ENSG00000256712
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAGOHB on UCSC Golden Path with GeneCards custom track

Promoters for MAGOHB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001461331 123 2200 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for MAGOHB Gene

Chromosome:
12
Start:
10,603,765 bp from pter
End:
10,613,623 bp from pter
Size:
9,859 bases
Orientation:
Minus strand

Genomic View for MAGOHB Gene

Genes around MAGOHB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGOHB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGOHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGOHB Gene

Proteins for MAGOHB Gene

  • Protein details for MAGOHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A72-MGN2_HUMAN
    Recommended name:
    Protein mago nashi homolog 2
    Protein Accession:
    Q96A72

    Protein attributes for MAGOHB Gene

    Size:
    148 amino acids
    Molecular mass:
    17276 Da
    Quaternary structure:
    • Interacts with RBM8A and is part of the exon junction complex (EJC).

neXtProt entry for MAGOHB Gene

Post-translational modifications for MAGOHB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGOHB Gene

Domains & Families for MAGOHB Gene

Protein Domains for MAGOHB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGOHB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A72

UniProtKB/Swiss-Prot:

MGN2_HUMAN :
  • Belongs to the mago nashi family.
Family:
  • Belongs to the mago nashi family.
genes like me logo Genes that share domains with MAGOHB: view

No data available for Gene Families for MAGOHB Gene

Function for MAGOHB Gene

Molecular function for MAGOHB Gene

UniProtKB/Swiss-Prot Function:
Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.

Gene Ontology (GO) - Molecular Function for MAGOHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MAGOHB: view
genes like me logo Genes that share phenotypes with MAGOHB: view

Animal Model Products

miRNA for MAGOHB Gene

miRTarBase miRNAs that target MAGOHB

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGOHB Gene

Localization for MAGOHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGOHB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGOHB gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MAGOHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0035145 exon-exon junction complex IDA 23917022
GO:0043025 neuronal cell body IEA --
GO:0071013 catalytic step 2 spliceosome IBA --
genes like me logo Genes that share ontologies with MAGOHB: view

Pathways & Interactions for MAGOHB Gene

genes like me logo Genes that share pathways with MAGOHB: view

Gene Ontology (GO) - Biological Process for MAGOHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IGI 23917022
GO:0006397 mRNA processing IEA --
GO:0006810 transport IEA --
GO:0008380 RNA splicing IEA,IBA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with MAGOHB: view

No data available for SIGNOR curated interactions for MAGOHB Gene

Transcripts for MAGOHB Gene

Unigene Clusters for MAGOHB Gene

Mago-nashi homolog B (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGOHB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - - - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for MAGOHB Gene

GeneLoc Exon Structure for
MAGOHB
ECgene alternative splicing isoforms for
MAGOHB

Expression for MAGOHB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAGOHB Gene

Protein differential expression in normal tissues from HIPED for MAGOHB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.5) and Nasal epithelium (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAGOHB Gene



Protein tissue co-expression partners for MAGOHB Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGOHB Gene:

MAGOHB

SOURCE GeneReport for Unigene cluster for MAGOHB Gene:

Hs.104650

mRNA Expression by UniProt/SwissProt for MAGOHB Gene:

Q96A72-MGN2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MAGOHB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAGOHB Gene

Orthologs for MAGOHB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAGOHB Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MAGOHB 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAGOHB 34 35
  • 99.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 99 (a)
ManyToMany
-- 35
  • 98 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia MAGOHB 34 35
  • 94.82 (n)
mouse
(Mus musculus)
Mammalia Magohb 34 16 35
  • 91.22 (n)
rat
(Rattus norvegicus)
Mammalia Magohb 34
  • 90.54 (n)
chicken
(Gallus gallus)
Aves MAGOH 35
  • 99 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 99 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia magoh 34
  • 83.33 (n)
zebrafish
(Danio rerio)
Actinopterygii magoh 34 35
  • 78.62 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010755 34
  • 72.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta mago 34 35
  • 70.57 (n)
worm
(Caenorhabditis elegans)
Secernentea mag-1 34 35
  • 65.75 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MAGO 34
  • 65.52 (n)
rice
(Oryza sativa)
Liliopsida Os12g0287200 34
  • 65.98 (n)
Os.12841 34
bread mold
(Neurospora crassa)
Ascomycetes NCU04405 34
  • 62.61 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mnh1 34
  • 57.87 (n)
Species where no ortholog for MAGOHB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAGOHB Gene

ENSEMBL:
Gene Tree for MAGOHB (if available)
TreeFam:
Gene Tree for MAGOHB (if available)

Paralogs for MAGOHB Gene

Paralogs for MAGOHB Gene

(1) SIMAP similar genes for MAGOHB Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for MAGOHB Gene

genes like me logo Genes that share paralogs with MAGOHB: view

Variants for MAGOHB Gene

Sequence variations from dbSNP and Humsavar for MAGOHB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_036431 A breast cancer sample
rs1026442 -- 10,612,432(-) TTAAC(C/T)ACAGT intron-variant
rs1026443 -- 10,612,329(-) cctcc(C/G)cctcc intron-variant
rs1026445 -- 10,611,415(-) TTGCA(C/T)ATTAT intron-variant
rs1026446 -- 10,611,354(-) ATACA(A/G)CAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGOHB Gene

Variant ID Type Subtype PubMed ID
nsv516351 CNV loss 19592680
nsv832329 CNV gain 17160897

Variation tolerance for MAGOHB Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGOHB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGOHB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGOHB Gene

Disorders for MAGOHB Gene

Relevant External Links for MAGOHB

Genetic Association Database (GAD)
MAGOHB
Human Genome Epidemiology (HuGE) Navigator
MAGOHB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGOHB

No disorders were found for MAGOHB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGOHB Gene

Publications for MAGOHB Gene

  1. Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. (PMID: 23917022) Singh K.K. … Gehring N.H. (RNA Biol 2013) 2 3 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for MAGOHB Gene

Sources for MAGOHB Gene

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