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Aliases for MAGOHB Gene

Aliases for MAGOHB Gene

  • Mago Homolog B, Exon Junction Complex Core Component 2 3
  • Mago-Nashi Homolog B (Drosophila) 2
  • Mago-Nashi Homolog 2 3
  • Mago-Nashi Homolog B 3
  • Mago Nashi Protein 3
  • MAGOH2 4
  • Magoh 3
  • MGN2 3
  • Mago 3

External Ids for MAGOHB Gene

Previous GeneCards Identifiers for MAGOHB Gene

  • GC12M010652
  • GC12M010756
  • GC12M010485

Summaries for MAGOHB Gene

GeneCards Summary for MAGOHB Gene

MAGOHB (Mago Homolog B, Exon Junction Complex Core Component) is a Protein Coding gene. Among its related pathways are RNA transport and mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is MAGOH.

UniProtKB/Swiss-Prot for MAGOHB Gene

  • Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGOHB Gene

Genomics for MAGOHB Gene

Regulatory Elements for MAGOHB Gene

Genomic Location for MAGOHB Gene

Chromosome:
12
Start:
10,603,765 bp from pter
End:
10,613,623 bp from pter
Size:
9,859 bases
Orientation:
Minus strand

Genomic View for MAGOHB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGOHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGOHB Gene

Proteins for MAGOHB Gene

  • Protein details for MAGOHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A72-MGN2_HUMAN
    Recommended name:
    Protein mago nashi homolog 2
    Protein Accession:
    Q96A72

    Protein attributes for MAGOHB Gene

    Size:
    148 amino acids
    Molecular mass:
    17276 Da
    Quaternary structure:
    • Interacts with RBM8A and is part of the exon junction complex (EJC).

neXtProt entry for MAGOHB Gene

Proteomics data for MAGOHB Gene at MOPED

Post-translational modifications for MAGOHB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGOHB Gene

Domains & Families for MAGOHB Gene

Protein Domains for MAGOHB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGOHB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A72

UniProtKB/Swiss-Prot:

MGN2_HUMAN :
  • Belongs to the mago nashi family.
Family:
  • Belongs to the mago nashi family.
genes like me logo Genes that share domains with MAGOHB: view

No data available for Gene Families for MAGOHB Gene

Function for MAGOHB Gene

Molecular function for MAGOHB Gene

UniProtKB/Swiss-Prot Function:
Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway.

Gene Ontology (GO) - Molecular Function for MAGOHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MAGOHB: view
genes like me logo Genes that share phenotypes with MAGOHB: view

Animal Model Products

CRISPR Products

miRNA for MAGOHB Gene

miRTarBase miRNAs that target MAGOHB

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGOHB Gene

Localization for MAGOHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGOHB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGOHB Gene COMPARTMENTS Subcellular localization image for MAGOHB gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for MAGOHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0035145 exon-exon junction complex IDA 23917022
GO:0071013 catalytic step 2 spliceosome IBA --
genes like me logo Genes that share ontologies with MAGOHB: view

Pathways & Interactions for MAGOHB Gene

genes like me logo Genes that share pathways with MAGOHB: view

Pathways by source for MAGOHB Gene

3 KEGG pathways for MAGOHB Gene

Gene Ontology (GO) - Biological Process for MAGOHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IGI 23917022
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IBA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with MAGOHB: view

No data available for SIGNOR curated interactions for MAGOHB Gene

Drugs & Compounds for MAGOHB Gene

No Compound Related Data Available

Transcripts for MAGOHB Gene

Unigene Clusters for MAGOHB Gene

Mago-nashi homolog B (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGOHB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGOHB Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - - - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for MAGOHB Gene

GeneLoc Exon Structure for
MAGOHB
ECgene alternative splicing isoforms for
MAGOHB

Expression for MAGOHB Gene

mRNA expression in normal human tissues for MAGOHB Gene

Protein differential expression in normal tissues from HIPED for MAGOHB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.5) and Nasal epithelium (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGOHB Gene



SOURCE GeneReport for Unigene cluster for MAGOHB Gene Hs.104650

mRNA Expression by UniProt/SwissProt for MAGOHB Gene

Q96A72-MGN2_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expression patterns with MAGOHB: view

Protein tissue co-expression partners for MAGOHB Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAGOHB Gene

Orthologs for MAGOHB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAGOHB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAGOHB 35
  • 94.82 (n)
  • 99.32 (a)
MAGOHB 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Magohb 35
  • 91.22 (n)
  • 97.97 (a)
Magohb 16
Magohb 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAGOHB 35
  • 99.55 (n)
  • 99.32 (a)
MAGOHB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Magohb 35
  • 90.54 (n)
  • 99.32 (a)
dog
(Canis familiaris)
Mammalia MAGOHB 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 99 (a)
ManyToMany
-- 36
  • 98 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MAGOH 36
  • 99 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 99 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia magoh 35
  • 83.33 (n)
  • 98.63 (a)
zebrafish
(Danio rerio)
Actinopterygii magoh 35
  • 78.62 (n)
  • 99.31 (a)
magoh 36
  • 98 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010755 35
  • 72.75 (n)
  • 90.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta mago 35
  • 70.57 (n)
  • 90.34 (a)
mago 36
  • 89 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mag-1 35
  • 65.75 (n)
  • 80.69 (a)
mag-1 36
  • 77 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MAGO 35
  • 65.52 (n)
  • 77.93 (a)
rice
(Oryza sativa)
Liliopsida Os.12841 35
Os12g0287200 35
  • 65.98 (n)
  • 82.07 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04405 35
  • 62.61 (n)
  • 69.59 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mnh1 35
  • 57.87 (n)
  • 62.5 (a)
Species with no ortholog for MAGOHB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAGOHB Gene

ENSEMBL:
Gene Tree for MAGOHB (if available)
TreeFam:
Gene Tree for MAGOHB (if available)

Paralogs for MAGOHB Gene

Paralogs for MAGOHB Gene

(1) SIMAP similar genes for MAGOHB Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for MAGOHB Gene

genes like me logo Genes that share paralogs with MAGOHB: view

Variants for MAGOHB Gene

Sequence variations from dbSNP and Humsavar for MAGOHB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1026442 -- 10,612,432(-) TTAAC(C/T)ACAGT intron-variant
rs1026443 -- 10,612,329(-) cctcc(C/G)cctcc intron-variant
rs1026445 -- 10,611,415(-) TTGCA(C/T)ATTAT intron-variant
rs1052871 -- 10,606,104(-) GTCCA(A/C/T)ATGGG utr-variant-3-prime
rs1054396 -- 10,604,256(-) TAGAT(A/T)TTTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAGOHB Gene

Variant ID Type Subtype PubMed ID
nsv832329 CNV Gain 17160897
nsv516351 CNV Loss 19592680

Variation tolerance for MAGOHB Gene

Residual Variation Intolerance Score: 41.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGOHB Gene

HapMap Linkage Disequilibrium report
MAGOHB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGOHB Gene

Disorders for MAGOHB Gene

Relevant External Links for MAGOHB

Genetic Association Database (GAD)
MAGOHB
Human Genome Epidemiology (HuGE) Navigator
MAGOHB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGOHB
genes like me logo Genes that share disorders with MAGOHB: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGOHB Gene

Publications for MAGOHB Gene

  1. Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. (PMID: 23917022) Singh K.K. … Gehring N.H. (RNA Biol 2013) 2 67
  2. Molecular identification and characterization of Tcmago and TcY14 in Taiwania (Taiwania cryptomerioides). (PMID: 17545126) Chen Y.R. … Chu F.H. (Tree Physiol. 2007) 23 67
  3. Molecular control of serial module formation along the apical-basal axis in the sponge Lubomirskia baicalensis: silicateins, mannose-binding lectin and mago nashi. (PMID: 16380844) Wiens M. … MA1ller W.E. (Dev. Genes Evol. 2006) 23 67
  4. Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module. (PMID: 15166247) Degot S. … Tomasetto C. (J. Biol. Chem. 2004) 23 67
  5. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex. (PMID: 14968132) Bono F. … Conti E. (EMBO Rep. 2004) 23 67

Products for MAGOHB Gene

Sources for MAGOHB Gene

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