Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MAGOHB Gene

protein-coding   GIFtS: 56
GCID: GC12M010756

Mago-Nashi Homolog B (Drosophila)

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mago-Nashi Homolog B (Drosophila)1 2     magoh2
MGN22     Protein Mago Nashi Homolog 22
mago2     MAGOH23
Mago-Nashi Homolog 22     

External Ids:    HGNC: 255041   Entrez Gene: 551102   Ensembl: ENSG000001111967   UniProtKB: Q96A723   

Export aliases for MAGOHB gene to outside databases

Previous GC identifers: GC12M010652 GC12M010485


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MAGOHB Gene:
MAGOHB (mago-nashi homolog B (Drosophila)) is a protein-coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is MAGOH.

UniProtKB/Swiss-Prot: MGN2_HUMAN, Q96A72
Function: Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAGOHB gene promoter:
         AML1a   FOXO3   FOXO3b   GATA-2   HEN1   IRF-2   POU2F1   POU2F1a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGOHB promoter sequence
   Search Chromatin IP Primers for MAGOHB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGOHB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13.2

MAGOHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGOHB gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010756:  view genomic region     (about GC identifiers)

Start:
10,756,364 bp from pter      End:
10,766,222 bp from pter
Size:
9,859 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MGN2_HUMAN, Q96A72 (See protein sequence)
Recommended Name: Protein mago nashi homolog 2  
Size: 148 amino acids; 17276 Da
Subunit: Interacts with RBM8A and is part of the exon junction complex (EJC) (By similarity)

Explore the universe of human proteins at neXtProt for MAGOHB: NX_Q96A72

Explore proteomics data for MAGOHB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys18, Lys43
  • Modification sites at PhosphoSitePlus

  • See MAGOHB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060518.1  
    ENSEMBL proteins: 
     ENSP00000437462   ENSP00000437512   ENSP00000319240   ENSP00000439091   ENSP00000439698  
     ENSP00000442440   ENSP00000437548   ENSP00000371305  

    MAGOHB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MAGOHB
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAGOHB
    GenScript Custom Purified and Recombinant Proteins Services for MAGOHB
    Novus Biologicals MAGOHB Proteins
    Novus Biologicals MAGOHB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAGOHB
    Cloud-Clone Corp. Proteins for MAGOHB

     
    Search eBioscience for Proteins for MAGOHB 

    MAGOHB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MAGOHB
    Novus Biologicals MAGOHB Antibodies
    Search for Antibodies for MAGOHB at Abcam
    Cloud-Clone Corp. Antibodies for MAGOHB
    Search ThermoFisher Antibodies for MAGOHB
    LSBio Antibodies in human, mouse, rat for MAGOHB

    MAGOHB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAGOHB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAGOHB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAGOHB
    Cloud-Clone Corp. CLIAs for MAGOHB
    Search eBioscience for ELISAs for MAGOHB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR004023 Mago_nashi

    Graphical View of Domain Structure for InterPro Entry Q96A72

    ProtoNet protein and cluster: Q96A72

    1 Blocks protein domain: IPB004023 Mago nashi protein

    UniProtKB/Swiss-Prot: MGN2_HUMAN, Q96A72
    Similarity: Belongs to the mago nashi family


    Find genes that share domains with MAGOHB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGN2_HUMAN, Q96A72
    Function: Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with MAGOHB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MAGOHB:
     Decreased cell number, increas 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAGOHB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAGOHB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAGOHB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAGOHB

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAGOHB:
    hsa-mir-20a-5p (MIRT050618)

    Block miRNA regulation of human, mouse, rat MAGOHB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAGOHB (see all 17):
    hsa-miR-320a hsa-miR-4307 hsa-miR-181c hsa-miR-4272 hsa-miR-421 hsa-miR-3119 hsa-miR-23a hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidMAGOHB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAGOHB
    Predesigned siRNA for gene silencing in human, mouse, rat MAGOHB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAGOHB

    Clone
    Products:
         
    OriGene clones in human, mouse for MAGOHB (see all 6)
    OriGene ORF clones in mouse, rat for MAGOHB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAGOHB (NM_018048)
    Sino Biological Human cDNA Clone for MAGOHB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGOHB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGOHB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAGOHB
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAGOHB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGOHB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MGN2_HUMAN, Q96A72: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with MAGOHB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MAGOHB About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome
    2RNA transport
    RNA transport
    3mRNA surveillance pathway
    mRNA surveillance pathway


    Find genes that share SuperPaths with MAGOHB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    3 Kegg Pathways  (Kegg details for MAGOHB):
        RNA transport
    mRNA surveillance pathway
    Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAGOHB
    Interactions:

        GeneGlobe Interaction Network for MAGOHB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for MAGOHB (Q96A722, 3 ENSP000003192404) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMG20AQ9NP662, 3, ENSP000003368564MINT-66920 I2D: score=5 STRING: ENSP00000336856
    RBM8AQ9Y5S92, 3, ENSP000003330014MINT-68487 I2D: score=10 STRING: ENSP00000333001
    ENSG00000221974Q927593I2D: score=5 
    ENSG00000226384Q927593I2D: score=5 
    ENSG00000233149Q927593I2D: score=5 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--
    GO:0051028mRNA transport IEA--

    Find genes that share ontologies with MAGOHB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAGOHB (MGN2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MAGOHB gene: 
    NM_018048.3  

    Unigene Cluster for MAGOHB:

    Mago-nashi homolog B (Drosophila)
    Hs.104650  [show with all ESTs]
    Unigene Representative Sequence: NM_018048
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398874 ENST00000539554 ENST00000544850 ENST00000537852(uc001qyr.2)
    ENST00000320756(uc001qyq.2) ENST00000540074 ENST00000545236 ENST00000543929
    ENST00000546173 ENST00000544176 ENST00000381881
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAGOHB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAGOHB (see all 17):
    hsa-miR-320a hsa-miR-4307 hsa-miR-181c hsa-miR-4272 hsa-miR-421 hsa-miR-3119 hsa-miR-23a hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidMAGOHB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAGOHB
    Predesigned siRNA for gene silencing in human, mouse, rat MAGOHB
    Clone
    Products:
         
    OriGene clones in human, mouse for MAGOHB (see all 6)
    OriGene ORF clones in mouse, rat for MAGOHB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAGOHB (NM_018048)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGOHB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGOHB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAGOHB
    OriGene qSTAR qPCR primer pairs in human, mouse for MAGOHB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAGOHB
      QuantiTect SYBR Green Assays in human, mouse, rat MAGOHB
      QuantiFast Probe-based Assays in human, mouse, rat MAGOHB

    Additional mRNA sequence: 

    AF165518.1 AK001154.1 AK022720.1 BC010905.1 

    14 DOTS entries:

    DT.110126  DT.92439363  DT.92439367  DT.100680654  DT.308826  DT.91912193  DT.100788082  DT.99932203 
    DT.99936630  DT.100723817  DT.100788085  DT.120759585  DT.95376404  DT.95300342 

    Selected AceView cDNA sequences (see all 127):

    CR604359 BX283230 CA413908 BX335457 BG178909 BG942717 BG531258 BU933036 
    AK022720 BU594477 BG504710 AW970820 NM_018048 AL709293 AK001154 BP350358 
    BI222433 AK096106 BG565399 BG532957 CD723604 BG493341 CA335184 BE881038 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAGOHB (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
    SP1:                    -     -                 -     -     -     -     -               
    SP2:                    -     -                 -                                       
    SP3:              -     -     -                 -                                       
    SP4:                          -                 -                                       
    SP5:                                            -                                       


    ECgene alternative splicing isoforms for MAGOHB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MAGOHB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTGGACAG
    MAGOHB Expression
    About this image

    MAGOHB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAGOHB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.104650

    UniProtKB/Swiss-Prot: MGN2_HUMAN, Q96A72
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for MAGOHB
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAGOHB
    OriGene qSTAR qPCR primer pairs in human, mouse for MAGOHB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAGOHB
    QuantiTect SYBR Green Assays in human, mouse, rat MAGOHB
    QuantiFast Probe-based Assays in human, mouse, rat MAGOHB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGOHB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAGOHB gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Magohb1 , 5 mago-nashi homolog B (Drosophila)1, 5 91.22(n)1
    97.97(a)1
      6 (63.44 cM)5
    664411  NM_025564.21  NP_079840.21 
     1312843885 
    chicken
    (Gallus gallus)
    Aves MAGOH6
    Gallus gallus mago-nashi homolog 2 (pseudogene) (M...
    99(a)
    1 → many
    8(23550024-23551699)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    99(a)
    1 → many
    4(115050211-115054192)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia magoh1 mago-nashi homolog, proliferation-associated 83.33(n)
    98.63(a)
      100038130  XM_002931425.2  XP_002931471.1 
    zebrafish
    (Danio rerio)
    Actinopterygii magoh1 mago-nashi homolog, proliferation-associated (Drosophila) 78.62(n)
    99.31(a)
      100005893  NM_001017700.1  NP_001017700.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mago1 mago nashi 70.57(n)
    90.34(a)
      37402  NM_057288.3  NP_476636.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mag-11 mag-1 65.75(n)
    80.69(a)
      173073  NM_060624.6  NP_493025.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MAGO1 MAGO 65.52(n)
    77.93(a)
      837560  NM_100094.2  NP_171716.1 
    rice
    (Oryza sativa)
    Liliopsida Os.128412 Oryza sativa mago nashi-like protein mRNA, complete more 75.21(n)    AF338343.1 


    ENSEMBL Gene Tree for MAGOHB (if available)
    TreeFam Gene Tree for MAGOHB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MAGOHB gene
    MAGOH2  
    1 SIMAP similar gene for MAGOHB using alignment to 6 protein entries:     MGN2_HUMAN (see all proteins):
    MAGOH

    Find genes that share paralogs with MAGOHB           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MAGOHB
    PGOHUM00000258796


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MAGOHB (see all 290)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364314
    A breast cancer sample4--see VAR_0364312 E K mis40--------
    rs1140441531,2
    F--10497173(+) GTAGTT/CATATA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs560182701,2
    C--10636488(+) AGACA-/TGT   
       AGACA
    ATAAA
    1 -- int11Minor allele frequency- TGTAGACA:0.00NA 2
    rs1825642651,2
    --10755873(+) GCGCCA/GCTGCA 1 -- ds50010--------
    rs42379301,2
    C,F,A,H--10755973(+) ACCCTT/GTTTGT 1 -- ds500119Minor allele frequency- G:0.16NA NS EA WA CSA 810
    rs1871719601,2
    --10756005(+) ATACAC/TTCAAA 1 -- ds50010--------
    rs1442046751,2
    C--10756148(+) ATGGC-/AAAAAA 1 -- ds50010--------
    rs107723321,2
    C,F,A,H--10756612(+) ACCAAC/TGAAAT 1 -- ut3125Minor allele frequency- T:0.26NA NS EA WA CSA 2402
    rs10543961,2
    C,F,O,A,H--10756855(-) TAGATT/ATTTAT 1 -- ut3124Minor allele frequency- A:0.28EA NA NS CSA WA 3955
    rs1395630881,2
    --10756883(+) TATTAA/TACAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MAGOHB (10756364 - 10766222 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MAGOHB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516351CNV Loss19592680
    nsv832329CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAGOHB
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGOHB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with MAGOHB           About GenesLikeMe

    Genetic Association Database (GAD): MAGOHB
    Human Genome Epidemiology (HuGE) Navigator: MAGOHB (1 document)

    Export disorders for MAGOHB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MAGOHB gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with MAGOHB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55110 HGNC: 25504 AceView: FLJ10292 Ensembl:ENSG00000111196 euGenes: HUgn55110
    ECgene: MAGOHB Kegg: 55110 H-InvDB: MAGOHB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MAGOHB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MAGOHB gene:
    Search GeneIP for patents involving MAGOHB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MAGOHB  
     OriGene qPCR primer pairs and template standards for MAGOHB   OriGene Protein Over-expression Lysate for MAGOHB  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MAGOHB  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAGOHB   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MAGOHB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAGOHB   OriGene Custom Protein Services for MAGOHB  

     
     
     Block miRNA regulation of human, mouse, rat MAGOHB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MAGOHB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGOHB Predesigned siRNA for gene silencing in human, mouse, rat MAGOHB
     QuantiFast Probe-based Assays in human, mouse, rat MAGOHB QuantiTect SYBR Green Assays in human, mouse, rat MAGOHB
     Custom PCR Arrays for MAGOHB Search Chromatin IP Primers for MAGOHB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAGOHB  GeneGlobe Interaction Network for MAGOHB
     Regulatory tfbs in MAGOHB promoter
     GenScript Custom Purified and Recombinant Proteins Services for MAGOHB GenScript cDNA clones with any tag delivered in your preferred vector for MAGOHB
     GenScript Custom Assay Services for MAGOHB GenScript Custom overexpressing Cell Line Services for MAGOHB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MAGOHB (MGN2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for MAGOHB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MAGOHB antibodies
     MAGOHB proteins
     MAGOHB lysates
     Search for Antibodies for MAGOHB at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MAGOHB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MAGOHB
     Proteins for MAGOHB
     Antibodies for MAGOHB
     ELISAs for MAGOHB
     CLIAs for MAGOHB



     Browse ESI BIO Cell Lines and PureStem Progenitors for MAGOHB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGOHB
     SwitchGear 3'UTR luciferase reporter plasmids for MAGOHB
     SwitchGear Promoter luciferase reporter plasmids for MAGOHB
     Search ThermoFisher Antibodies for MAGOHB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGOHB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAGOHB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAGOHB
     LSBio Antibodies in human, mouse, rat for MAGOHB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MAGOHB
      Search eBioscience for proteins for MAGOHB
      Search eBioscience for elisas for MAGOHB
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAGOHB gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4