 |
 | Services
| |
 |
Aliases & Descriptions for MAGOH
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MAGOHA 1, 2 | | OTTHUMP00000010485 2 |
| | | Descriptions |
|---|
| mago-nashi (Drosophila) homolog, proliferation-associated 1 | | mago-nashi homolog 2 | | mago-nashi homolog, proliferation-associated (Drosophila) 2 |
|
| | Search outside databases for aliases for MAGOH genePrevious GC identifers: GC01M053327 GC01M052581 GC01M053051 GC01M053062 |
Summaries for MAGOH(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for MAGOH: Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq] UniProtKB/Swiss-Prot: MGN_HUMAN, P61326Function: Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathwayGene Wiki entry for MAGOH |
Genomic Location for MAGOH
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the MAGOH gene 
Entrez Gene cytogenetic band: 1p34-p33 Ensembl cytogenetic band: 1p32.3 HGNC cytogenetic band: 1p32.3MAGOH Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M053404:
(about GC identifiers)
Start:
|
53,465,152 bp from pter |
End:
|
53,476,795 bp from pter |
Size:
|
11,644 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_032977.8
| Proteins for MAGOH
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MGN_HUMAN, P61326 (See
protein sequence)Recommended Name: Protein mago nashi homolog Size: 146 amino acids; 17164 Da
Subunit: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Interacts with RBM8A and is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2 and THOC4. Remains associated with the mRNA after its export to the cytoplasm and require translation of the mRNA for removal. Interacts with WIBG/PYM; the interaction is direct and leads to dissociate the EJC from spliced mRNAs
Subcellular location: Nucleus (By similarity)
PDB structures from and Proteopedia :1P27 (3D)
 2HYI (3D)
 2J0Q (3D)
 2J0S (3D)
 3EX7 (3D)
 
Secondary accessions: O35169 P50606 Q5SW69Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002361.1
ENSEMBL proteins: ENSP00000360521 ENSP00000360525
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for MAGOH: Assays for MAGOH: | Protein
Domains/ Families for MAGOH(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P61326
ProtoNet protein and cluster: P61326 UniProtKB/Swiss-Prot: MGN_HUMAN, P61326Similarity: Belongs to the mago nashi family | Gene Function for MAGOH
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002370
Applied Biosystems Silencer® siRNAs for MAGOH
Sigma-Aldrich siRNA for MAGOH  Sigma-Aldrich shRNA for MAGOH  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002370                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002370                                  untagged cDNA clone in CMV expression vector: NM_002370 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002370
UniProtKB/Swiss-Prot: MGN_HUMAN, P61326Function: Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathwayGenatlas biochemistry entry for MAGOH:Drosophila Mago Nashi (grandchildless) homolog,determining the localization and fate of germ cells during Drosophila germ plasm development,expressed ubiquitously adult tissues2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for MAGOH
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for MAGOH 
5/109 Interacting proteins for MAGOH (ENSP000003605253 P613261, 2) via UniProtKB, MINT, and/or STRING (see all 109
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for MAGOH(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for MAGOH
|
Transcripts for MAGOH(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002370
Sigma-Aldrich siRNA for MAGOH  Sigma-Aldrich shRNA for MAGOH  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002370 REFSEQ mRNAs for MAGOH gene: NM_002370.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002370               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002370                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002370                                  untagged cDNA clone in CMV expression vector: NM_002370  Additional cDNA sequence: AF035940.1 AF067173.1 AF086246.1 AK297895.1 AK312113.1 BC018211.1 9 DOTS entries: DT.109824 DT.85104220 DT.40273016 DT.102826938 DT.86852796 DT.95202717 DT.95262307 DT.95262313 DT.121327765 24/78 AceView cDNA sequences (see all 78
):AA489775 BM808411 BX283982 BC018211 CF130293 C01289 BM824432 BE048136 AF086246 AI632611 BM770941 AA357603 AA504979 BM911523 AI863283 AA314669 BM914866 BM997952 BU619340 BM794469 BM771332 AI821560 BF448103 BG429919
highest scoring ESTs for MAGOH:AF035940 AA307757 AA314669 AA314742 AF067173 AI632611 AV756132 AW104858 AW955286 BC018211 Unigene Cluster for MAGOH: Mago-nashi homolog, proliferation-associated (Drosophila) Hs.421576 [show with all ESTs]Unigene Representative Sequence: BM914866
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000371466
ENST00000371470
|
Expression for MAGOH
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MAGOH expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MAGOH
1 / 2 / 3 5 probe-sets matching MAGOH gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGGGGTGGGT
SOURCE GeneReport for Unigene cluster: Hs.421576
Expression variation in blood from EXPOLDB for MAGOH UniProtKB/Swiss-Prot: MGN_HUMAN, P61326Tissue specificity: Ubiquitous |
Orthologs for MAGOH
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MAGOH gene from 5/18 species (see all 18
)
About this table Species with no ortholog for MAGOH
ENSEMBL Gene Tree for MAGOH | Paralogs for MAGOH(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for MAGOH gene
- MAGOHB2
|
SNPs/Variants for MAGOH(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for MAGOH (up to first 250kb)
|
Disorders & Mutations for MAGOH
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602603
|
Medical News for MAGOH(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for MAGOH (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/25 PubMed articles for MAGOH gene (see all 25
):- The mammalian homologue of mago nashi encodes a serum-inducible protein. (PubMed id 9479507)1, 2, 3, 4 Zhao X.F....Aplan P.D. (1998)
- MAGOH interacts with a novel RNA-binding protein. (PubMed id 10662555)1, 3, 4 Zhao X.F.... Aplan P.D. (2000)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- Exon-junction complex components specify distinct routes of nonsense- mediated mRNA decay with differential cofactor requirements. (PubMed id 16209946)3, 4 Gehring N.H.... Kulozik A.E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- A novel mode of RBD-protein recognition in the Y14-Mago complex. (PubMed id 12730685)3, 4 Fribourg S.... Conti E. (2003)
- Structure of the Y14-Magoh core of the exon junction complex. (PubMed id 12781131)3, 4 Lau C.K.... Van Duyne G.D. (2003)
- Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)3, 4 Jurica M.S.... Moore M.J. (2002)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)3, 4 Zhang Q.H....Chen Z. (2000)
- The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation. (PubMed id 19254694)3 Muromoto R....Matsuda T. (2009)
|
Search for MAGOH
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MAGOH
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MAGOH
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGOH(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for MAGOH(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for MAGOH:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for MAGOH |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|