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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGOH Gene

protein-coding   GIFtS: 57
GCID: GC01M053692

mago-nashi homolog, proliferation-associated (Drosophila)

(Previous names: mago-nashi (Drosophila) homolog, proliferation-associated...)
 Explore 1 disease affiliated with
MAGOH via our new
 Human Malady Compendium 
Biological research products
for MAGOH
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mago-Nashi Homolog, Proliferation-Associated (Drosophila)1 2
MAGOHA1 2 3
MAGOH11 2
Mago-Nashi (Drosophila) Homolog, Proliferation-Associated1
Protein Mago Nashi Homolog2

External Ids:    HGNC: 68151   Entrez Gene: 41162   Ensembl: ENSG000001623857   OMIM: 6026035   UniProtKB: P613263   

Export aliases for MAGOH gene to outside databases

Previous GC identifers: GC01M053327 GC01M052581 GC01M053051 GC01M053062 GC01M053404 GC01M053465 GC01M051808


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAGOH:
Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm
assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is
not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation
of quiescent fibroblasts. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
Function: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on
mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and
cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent
mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA
metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences
downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization,
translation efficiency and nonsense-mediated mRNA decay (NMD). Remains associated with the mRNA after its export to
the cytoplasm and require translation of the mRNA for removal. The heterodimer MAGOH-RBM8A interacts with PYM that
function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation
complex

Gene Wiki entry for MAGOH


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGOH gene promoter:
         SRF   SRF (504 AA)   FOXO3   XBP-1   CUTL1   E47   FOXO3b   COMP1   FOXO3a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGOH promoter sequence
   Search SABiosciences Chromatin IP Primers for MAGOH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGOH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

MAGOH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGOH gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M053692:  view genomic region     (about GC identifiers)

Start:
53,692,564 bp from pter      End:
53,704,282 bp from pter
Size:
11,719 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MGN_HUMAN, P61326 (See protein sequence)
Recommended Name: Protein mago nashi homolog  
Size: 146 amino acids; 17164 Da
Subunit: Heterodimer with RBM8A. Part of the EJC core complex that contains CASC3, EIF4A3, MAGOH and RBM8A. Found in a
mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3, EIF4A3, MAGOH, NCBP1, NCBP2,
PNN, RBM8A, RNPS1, SRRM1, NXF1, SAP18, UPF3B, UPF2 and ALYREF/THOC4. Interacts with WIBG/PYM; the interaction is
direct and leads to dissociate the EJC from spliced mRNAs. Identified in the spliceosome C complex
Subcellular location: Nucleus. Nucleus speckle. Cytoplasm. Note=Detected in granule-like structures in the dendroplasm
(By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with
the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles
6 PDB 3D structures from and Proteopedia for MAGOH:
1P27 (3D)        2HYI (3D)        2J0Q (3D)        2J0S (3D)        2XB2 (3D)        3EX7 (3D)    
Secondary accessions: B2R5A2 O35169 P50606 Q5SW69

Explore the universe of human proteins at neXtProt for MAGOH: NX_P61326

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61326

  • MAGOH Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002361.1  
    ENSEMBL proteins: 
     ENSP00000360525   ENSP00000360521  
    Reactome Protein details: P61326
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: MAGOH
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    Novus Biologicals MAGOH Proteins
    Novus Biologicals MAGOH Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MAGOH
    Uscn Proteins for MAGOH

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0016607nuclear speck IEA--
    GO:0035145exon-exon junction complex IDA16601204


    MAGOH for ontologies           About GeneDecksing



    MAGOH Antibody Products: 
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    Uscn Antibodies for MAGOH
    ThermoFisher Antibodies for MAGOH

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    Uscn ELISAs and CLIAs for MAGOH


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MAGOH for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004023 Mago_nashi

    Graphical View of Domain Structure for InterPro Entry P61326

    ProtoNet protein and cluster: P61326

    UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
    Similarity: Belongs to the mago nashi family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
    Function: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on
    mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and
    cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent
    mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA
    metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences
    downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization,
    translation efficiency and nonsense-mediated mRNA decay (NMD). Remains associated with the mRNA after its export to
    the cytoplasm and require translation of the mRNA for removal. The heterodimer MAGOH-RBM8A interacts with PYM that
    function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation
    complex

         Genatlas biochemistry entry for MAGOH:
    Drosophila Mago Nashi (grandchildless) homolog,determining the localization and fate of germ cells during Drosophila
    germ plasm development,expressed ubiquitously adult tissues

    miRNA
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    OriGene 3'-UTR Clone: MAGOH
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAGOH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MAGOH
    SwitchGear 3'UTR luciferase reporter plasmidMAGOH 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAGOH (see all 7)
    OriGene shRNA RFP: MAGOH
    OriGene siRNA: MAGOH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAGOH

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MAGOH (NM_002370)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGOH 

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    In Situ Assay
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MAGOH

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI19417104


    MAGOH for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for MAGOH:
     Cell division defect  Decreased cell number, increas  Decreased viability of wild-ty  Increased number of mitotic ce 
     Synthetic lethal with Ras 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Magoh):
     cellular  growth/size  mortality/aging  nervous system  pigmentation 

    MAGOH for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination1.00
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    Post-Elongation Processing of the Transcript1.00
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 1.00
    2mRNA Splicing - Major Pathway
    mRNA Splicing1.00
    mRNA Processing0.82
    mRNA Splicing - Major Pathway1.00
    Spliceosome0.31
    Processing of Capped Intron-Containing Pre-mRNA0.96
    3Synthesis of PB1-F2
    SMG6 Cleaves mRNA with Premature Termination Codon0.80
    Nonsense-Mediated Decay0.77
    Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A0.77
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.77
    4Metabolism of mRNA
    Metabolism of mRNA1.00
    Metabolism of RNA0.92
    5Transcription
    Transcription1.00
    RNA Polymerase II Transcription0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/20        Reactome Pathways for MAGOH (see all 20)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    Nonsense-Mediated Decay
    Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    RNA Polymerase II Transcription


    3         Kegg Pathways  (Kegg details for MAGOH):
        RNA transport
    mRNA surveillance pathway
    Spliceosome


    MAGOH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAGOH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for MAGOH (P613261, 2, 3 ENSP000003605254) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBM8AQ9Y5S91, 2, 3, ENSP000003330014EBI-299134,EBI-447231 MINT-8337860 I2D: score=5 STRING: ENSP00000333001
    EIF4A3P389191, 3, ENSP000002693494EBI-299134,EBI-299104 I2D: score=3 STRING: ENSP00000269349
    IPO13O948292, 3, ENSP000003614184MINT-8109916 MINT-8109339 I2D: score=4 STRING: ENSP00000361418
    NME2P223923, ENSP000003655724I2D: score=1 STRING: ENSP00000365572
    CASC3O152341, 3, ENSP000002646454EBI-299134,EBI-299118 I2D: score=1 STRING: ENSP00000264645
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006406mRNA export from nucleus TAS--


    MAGOH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAGOH
    Search CenterWatch for drugs/clinical trials and news about MAGOH / MGN 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAGOH gene: 
    NM_002370.3  

    Unigene Cluster for MAGOH:

    Mago-nashi homolog, proliferation-associated (Drosophila)
    Hs.421576  [show with all ESTs]
    Unigene Representative Sequence: BM914866
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371470(uc001cvf.2 uc010ont.2) ENST00000371466 ENST00000495868
    ENST00000462941

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAGOH
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    SwitchGear 3'UTR luciferase reporter plasmidMAGOH 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAGOH (see all 7)
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MAGOH (NM_002370)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGOH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGOH

    Additional cDNA sequence: 

    AF035940.1 AF067173.1 AF086246.1 AK297895.1 AK312113.1 BC018211.1 

    9 DOTS entries:

    DT.109824  DT.85104220  DT.40273016  DT.102826938  DT.86852796  DT.95202717  DT.95262307  DT.95262313 
    DT.121327765 

    24/78 AceView cDNA sequences (see all 78):

    AA504979 BM770941 AI821560 BC018211 AI632611 BF448103 BM911523 AF086246 
    AI863283 BM771332 BM808411 AA314669 BM914866 C01289 BX283982 AA489775 
    BE048136 BU619340 CF130293 AA357603 BM794469 BM824432 BM997952 BG429919 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGOH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGGGTGGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MAGOH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAGOH

    SOURCE GeneReport for Unigene cluster: Hs.421576

    UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for MAGOH
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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MAGOH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAGOH gene from 7/32 species (see all 32)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MAGOH1 mago-nashi homolog, proliferation-associated (Drosophila) 83.56(n)
    99.32(a)
      374226  NM_204325.1  NP_989656.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC642742 hypothetical protein MGC64274 81.72(n)    AF007860.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.135172 Transcribed sequence with strong similarity to protein more 80.86(n)    BI865687.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mago1 , 3 protein localization3
    mago nashi1
    91(a)3
    71.79(n)1
    91.61(a)1
      57C23
    374021  NM_057288.31  NP_476636.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mag-11 Protein MAG-1 65.51(n)
    80.56(a)
      173073  NM_060624.5  NP_493025.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MEE636
    protein mago nashi
    75(a)
    possible ortholog
    1(403190-404456)
    rice
    (Oryza sativa)
    Liliopsida CF291311.12   -- 76.28(n)    CF291311.1 


    ENSEMBL Gene Tree for MAGOH (if available)
    TreeFam Gene Tree for MAGOH (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGOH gene
    MAGOHB2  
    1 SIMAP similar gene for MAGOH using alignment to 2 protein entries:     MGN_HUMAN (see all proteins):
    MAGOHB

    MAGOH for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MAGOH
    PGOHUM00000236920 PGOHUM00000235219


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/215 NCBI SNPs in MAGOH are shown (see all 215    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830810111,2
    --53692077(+) CCAAGC/TGATTT 1 -- int10--------
    rs1448917741,2
    C,--53692246(+) CACCA-/CCATCT 1 -- int10--------
    rs1458557941,2
    --53692297(+) GGGTC-/CAAA  
            
    CATTG
    1 -- int10--------
    rs1450466311,2
    --53692357(+) TTTCCA/CTTGTA 1 -- int10--------
    rs1170276471,2
    F,--53692407(+) TCTCAA/GTATGG 1 -- int11Minor allele frequency- G:0.03EA 120
    rs1388291451,2
    --53692430(+) CCACTA/GTATTT 1 -- int10--------
    rs121334641,2
    C,F,A,H,--53692437(+) ATTTTT/AAAAAC 1 -- int19Minor allele frequency- A:0.29NS EA NA WA 780
    rs121368371,2
    C,F,A,H,--53692488(+) TATCTA/GGAGAG 1 -- int118Minor allele frequency- G:0.23NS EA NA WA 2230
    rs1870972791,2
    C,--53692674(+) AAAATG/TTTCTA 1 -- ut310--------
    rs1995558081,2
    --53692682(+) CTACTC/TCCACC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MAGOH (53692564 - 53704282 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MAGOH
         1 CNV: 5196

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MAGOH for disorders           About GeneDecksing

    OMIM gene information: 602603    OMIM disorders: --

    1 disease for MAGOH:    About MalaCards
    malaria


    Export disorders for MAGOH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGOH gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with MAGOH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The mammalian homologue of mago nashi encodes a serum-inducible protein. (PubMed id 9479507)1, 2, 3, 9 Zhao X.F....Aplan P.D. (1998)
    2. MAGOH interacts with a novel RNA-binding protein. (PubMed id 10662555)1, 2, 9 Zhao X.F.... Aplan P.D. (2000)
    3. Disassembly of exon junction complexes by PYM. (PubMed id 19410547)1, 2 Gehring N.H.... Hentze M.W. (2009)
    4. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. (PubMed id 18026120)1, 2 Diem M.D.... Dreyfuss G. (2007)
    5. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. (PubMed id 16931718)1, 2 Andersen C.B....Andersen G.R. (2006)
    6. The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. (PubMed id 16923391)1, 2 Bono F.... Conti E. (2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Exon-junction complex components specify distinct routes of nonsense- mediated mRNA decay with differential cofactor requirements. (PubMed id 16209946)1, 2 Gehring N.H.... Kulozik A.E. (2005)
    9. The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. (PubMed id 16170325)1, 2 Ballut L....Le Hir H. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4116 HGNC: 6815 AceView: MAGOH Ensembl:ENSG00000162385 euGenes: HUgn4116
    ECgene: MAGOH Kegg: 4116 H-InvDB: MAGOH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAGOH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAGOH gene:
    Search GeneIP for patents involving MAGOH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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