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MAGOH Gene

protein-coding   GIFtS: 63
GCID: GC01M053692

Mago-Nashi Homolog, Proliferation-Associated (Drosophila)

(Previous names: mago-nashi (Drosophila) homolog, proliferation-associated)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mago-Nashi Homolog, Proliferation-Associated (Drosophila)1 2
MAGOHA2 3
Mago-Nashi (Drosophila) Homolog, Proliferation-Associated1
MAGOH12
Protein Mago Nashi Homolog2

External Ids:    HGNC: 68151   Entrez Gene: 41162   Ensembl: ENSG000001623857   OMIM: 6026035   UniProtKB: P613263   

Export aliases for MAGOH gene to outside databases

Previous GC identifers: GC01M053327 GC01M052581 GC01M053051 GC01M053062 GC01M053404 GC01M053465 GC01M051808


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAGOH Gene:
Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm
assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA
expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by
serum stimulation of quiescent fibroblasts. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAGOH Gene:
MAGOH (mago-nashi homolog, proliferation-associated (Drosophila)) is a protein-coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is MAGOHB.

UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
Function: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice
junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and
cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during
subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene
expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA
metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization,
translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase
activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The
MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm
and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation
complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically
inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC
assembly

Gene Wiki entry for MAGOH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAGOH gene promoter:
         SRF   SRF (504 AA)   FOXO3   XBP-1   CUTL1   E47   FOXO3b   COMP1   FOXO3a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGOH promoter sequence
   Search Chromatin IP Primers for MAGOH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGOH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

MAGOH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGOH gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M053692:  view genomic region     (about GC identifiers)

Start:
53,692,564 bp from pter      End:
53,704,282 bp from pter
Size:
11,719 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MGN_HUMAN, P61326 (See protein sequence)
Recommended Name: Protein mago nashi homolog  
Size: 146 amino acids; 17164 Da
Subunit: Heterodimer with RBM8A. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core
complex contains CASC3, EIF4A3, MAGOH and RBM8A. Interacts with WIBG/PYM; the interaction is direct and
dissociates the EJC from spliced mRNAs. Identified in the spliceosome C complex
6 PDB 3D structures from and Proteopedia for MAGOH:
1P27 (3D)        2HYI (3D)        2J0Q (3D)        2J0S (3D)        2XB2 (3D)        3EX7 (3D)    
Secondary accessions: B2R5A2 O35169 P50606 Q5SW69

Explore the universe of human proteins at neXtProt for MAGOH: NX_P61326

Explore proteomics data for MAGOH at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys16, Lys41
  • Modification sites at PhosphoSitePlus

  • See MAGOH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002361.1  
    ENSEMBL proteins: 
     ENSP00000360525   ENSP00000360521  
    Reactome Protein details: P61326

    MAGOH Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MAGOH

     
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    antibodies-online proteins for MAGOH (16 products) 

     
    antibodies-online peptides for MAGOH

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    antibodies-online antibodies for MAGOH (48 products) 

    MAGOH Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004023 Mago_nashi

    Graphical View of Domain Structure for InterPro Entry P61326

    ProtoNet protein and cluster: P61326

    UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
    Similarity: Belongs to the mago nashi family


    Find genes that share domains with MAGOH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGN_HUMAN, P61326
    Function: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice
    junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and
    cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during
    subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene
    expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA
    metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization,
    translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase
    activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The
    MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm
    and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation
    complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically
    inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC
    assembly

         Genatlas biochemistry entry for MAGOH:
    Drosophila Mago Nashi (grandchildless) homolog,determining the localization and fate of germ cells during
    Drosophila germ plasm development,expressed ubiquitously adult tissues

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI10662555
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with MAGOH           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAGOH:
     Cell division defect  Decreased cell number, increas  Decreased viability of wild-ty  Increased number of mitotic ce 
     Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Magoh):
     cellular  growth/size/body  mortality/aging  nervous system  pigmentation 

    Find genes that share phenotypes with MAGOH           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MAGOH

    miRNA
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    miRTarBase miRNAs that target MAGOH:
    hsa-mir-615-3p (MIRT040138)

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    SwitchGear 3'UTR luciferase reporter plasmidMAGOH 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MGN_HUMAN, P61326: Nucleus. Nucleus speckle. Cytoplasm. Note=Detected in granule-like structures in the
    dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
    Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0016607nuclear speck IEA--
    GO:0035145exon-exon junction complex IDA16601204

    Find genes that share ontologies with MAGOH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAGOH About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    mRNA 3-end processing0.80
    Cleavage of Growing Transcript in the Termination Region0.80
    2mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93
    Transport of Mature Transcript to Cytoplasm0.93
    4Influenza Viral RNA Transcription and Replication
    Nonsense-Mediated Decay0.89
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    5Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60


    Find genes that share SuperPaths with MAGOH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5 Reactome Pathways for MAGOH
        mRNA Splicing - Major Pathway
    Transport of Mature mRNA derived from an Intron-Containing Transcript
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
    mRNA 3'-end processing
    Cleavage of Growing Transcript in the Termination Region


    3 Kegg Pathways  (Kegg details for MAGOH):
        RNA transport
    mRNA surveillance pathway
    Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAGOH
    Interactions:

        GeneGlobe Interaction Network for MAGOH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAGOH (P613261, 2, 3 ENSP000003605254) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBM8AQ9Y5S91, 2, 3, ENSP000003330014EBI-299134,EBI-447231 MINT-8337860 I2D: score=5 STRING: ENSP00000333001
    IPO13O948291, 2, 3, ENSP000003614184EBI-299134,EBI-747310 MINT-8109916 MINT-8109339 I2D: score=4 STRING: ENSP00000361418
    NME2P223923, ENSP000003655724I2D: score=1 STRING: ENSP00000365572
    CASC3O152341, 3, ENSP000002646454EBI-299134,EBI-299118 I2D: score=1 STRING: ENSP00000264645
    EIF4A3P389191, 3, ENSP000002693494EBI-299134,EBI-299104 I2D: score=3 STRING: ENSP00000269349
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IMP--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--

    Find genes that share ontologies with MAGOH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAGOH (MGN)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAGOH gene: 
    NM_002370.3  

    Unigene Cluster for MAGOH:

    Mago-nashi homolog, proliferation-associated (Drosophila)
    Hs.421576  [show with all ESTs]
    Unigene Representative Sequence: BM914866
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371470(uc001cvf.2 uc010ont.2) ENST00000371466 ENST00000495868
    ENST00000462941
    miRNA
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    Additional mRNA sequence: 

    AF035940.1 AF067173.1 AF086246.1 AK297895.1 AK312113.1 BC018211.1 

    9 DOTS entries:

    DT.109824  DT.85104220  DT.40273016  DT.102826938  DT.86852796  DT.95202717  DT.95262307  DT.95262313 
    DT.121327765 

    Selected AceView cDNA sequences (see all 78):

    AF086246 BX283982 BM771332 AA504979 CF130293 BM997952 BM794469 BC018211 
    AI632611 AI863283 BM808411 BM770941 BF448103 BM911523 AI821560 BU619340 
    AA314669 BE048136 AA489775 AA357603 BM914866 C01289 BM824432 NM_002370 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAGOH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGGTGGGT
    MAGOH Expression
    About this image


    MAGOH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    MAGOH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAGOH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.421576

    UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for MAGOH
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGOH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAGOH gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Magoh1 , 5 mago-nashi homolog, proliferation-associated (Drosophila)1, 5 91.1(n)1
    100(a)1
      4 (50.18 cM)5
    171491  NM_001282737.11  NP_001269666.11 
     1078797555 
    chicken
    (Gallus gallus)
    Aves MAGOH21 mago-nashi homolog 2 (pseudogene) 83.56(n)
    99.32(a)
      374226  NM_204325.2  NP_989656.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    99(a)
    1 → many
    4(115050211-115054192)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC642742 hypothetical protein MGC64274 81.72(n)    AF007860.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.135172 Transcribed sequence with strong similarity to protein more 80.86(n)    BI865687.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mago3 protein localization 91(a)   57C2   --
    worm
    (Caenorhabditis elegans)
    Secernentea mag-16
    Protein MAG-1 (mag-1) mRNA, complete cds
    76(a)
    1 → many
    I(11911755-11912677) WBGene00003123
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.16072 Vitis vinifera transcribed sequence with moderate similarity more 77.2(n)    CB982464.1 
    rice
    (Oryza sativa)
    Liliopsida CF291311.12   -- 76.28(n)    CF291311.1 


    ENSEMBL Gene Tree for MAGOH (if available)
    TreeFam Gene Tree for MAGOH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAGOH gene
    MAGOHB2  
    1 SIMAP similar gene for MAGOH using alignment to 2 protein entries:     MGN_HUMAN (see all proteins):
    MAGOHB

    Find genes that share paralogs with MAGOH           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for MAGOH
    PGOHUM00000236920 PGOHUM00000235219


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAGOH (see all 188)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830810111,2
    --53692077(+) CCAAGC/TGATTT 1 -- int10--------
    rs1448917741,2
    C--53692248(+) CACCA-/CCATCT 1 -- int10--------
    rs1458557941,2
    C--53692297(+) GGGTC-/CAAA  
            
    CATTG
    1 -- int10--------
    rs1450466311,2
    --53692357(+) TTTCCA/CTTGTA 1 -- int10--------
    rs1170276471,2
    F--53692407(+) TCTCAA/GTATGG 1 -- int11Minor allele frequency- G:0.03EA 120
    rs1388291451,2
    --53692430(+) CCACTA/GTATTT 1 -- int10--------
    rs121334641,2
    C,F,A,H--53692437(+) ATTTTT/AAAAAC 1 -- int19Minor allele frequency- A:0.29NS EA NA WA 780
    rs121368371,2
    C,F,A,H--53692488(+) TATCTA/GGAGAG 1 -- int118Minor allele frequency- G:0.23NS EA NA WA 2230
    rs1870972791,2
    C--53692674(+) AAAATG/TTTCTA 1 -- ut310--------
    rs1995558081,2
    --53692682(+) CTACTC/TCCACC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MAGOH (53692564 - 53704282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MAGOH:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422213CNV Duplication17116639
    nsv829871CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAGOH
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGOH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602603    OMIM disorders: --


    Find genes that share disorders with MAGOH           About GenesLikeMe

    Genetic Association Database (GAD): MAGOH

    Export disorders for MAGOH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAGOH gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with MAGOH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The mammalian homologue of mago nashi encodes a serum-inducible protein. (PubMed id 9479507)1, 2, 3, 9 Zhao X.F....Aplan P.D. (Genomics 1998)
    2. MAGOH interacts with a novel RNA-binding protein. (PubMed id 10662555)1, 2, 9 Zhao X.F.... Aplan P.D. (Genomics 2000)
    3. Disassembly of exon junction complexes by PYM. (PubMed id 19410547)1, 2 Gehring N.H.... Hentze M.W. (Cell 2009)
    4. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. (PubMed id 18026120)1, 2 Diem M.D.... Dreyfuss G. (Nat. Struct. Mol. Biol. 2007)
    5. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. (PubMed id 16931718)1, 2 Andersen C.B.... Andersen G.R. (Science 2006)
    6. The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. (PubMed id 16923391)1, 2 Bono F.... Conti E. (Cell 2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Exon-junction complex components specify distinct routes of nonsense- mediated mRNA decay with differential cofactor requirements. (PubMed id 16209946)1, 2 Gehring N.H.... Kulozik A.E. (Mol. Cell 2005)
    9. The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. (PubMed id 16170325)1, 2 Ballut L....Le Hir H. (Nat. Struct. Mol. Biol. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4116 HGNC: 6815 AceView: MAGOH Ensembl:ENSG00000162385 euGenes: HUgn4116
    ECgene: MAGOH Kegg: 4116 H-InvDB: MAGOH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAGOH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAGOH gene:
    Search GeneIP for patents involving MAGOH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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