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Aliases for MAGOH Gene

Aliases for MAGOH Gene

  • Mago Homolog, Exon Junction Complex Core Component 2 3 5
  • MAGOHA 3 4
  • Mago-Nashi (Drosophila) Homolog, Proliferation-Associated 2
  • Mago-Nashi Homolog, Proliferation-Associated (Drosophila) 2
  • Mago-Nashi Homolog, Proliferation-Associated 3
  • Protein Mago Nashi Homolog 3
  • MAGOH1 3

External Ids for MAGOH Gene

Previous GeneCards Identifiers for MAGOH Gene

  • GC01M053327
  • GC01M052581
  • GC01M053051
  • GC01M053062
  • GC01M053404
  • GC01M053465
  • GC01M053692
  • GC01M051808

Summaries for MAGOH Gene

Entrez Gene Summary for MAGOH Gene

  • Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGOH Gene

MAGOH (Mago Homolog, Exon Junction Complex Core Component) is a Protein Coding gene. Diseases associated with MAGOH include Waardenburg Syndrome, Type 4A. Among its related pathways are Transport of Mature Transcript to Cytoplasm and mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is MAGOHB.

UniProtKB/Swiss-Prot for MAGOH Gene

  • Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.

Gene Wiki entry for MAGOH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGOH Gene

Genomics for MAGOH Gene

Regulatory Elements for MAGOH Gene

Enhancers for MAGOH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F054218 1.2 Ensembl ENCODE 57.2 -981.5 -981526 3.1 ZFP64 RAD21 ZNF354C SCRT2 EGR2 ZNF680 SP3 ZNF654 ZBTB11 REST SSBP3-AS1 MAGOH CYB5RL HSPB11 PARS2 C1orf123 MRPL37 CDCP2 USP24 PIR51493
GH01F054051 1.2 ENCODE 47.3 -814.5 -814545 3.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MAGOH ENSG00000228838 SSBP3-AS1 TCEANC2 RPL37P7 LOC105378729 PODN PARS2 C1orf123 CYB5RL
GH01F053942 1.1 ENCODE 39.4 -706.7 -706703 5.4 HDGF PKNOX1 ARID4B SIN3A FEZF1 YBX1 ZNF2 YY1 ZNF766 ZNF207 ENSG00000228838 MAGOH SSBP3-AS1 HSPB11 RPL37P7 LOC105378729 CYB5RL TTC4 TCEANC2 LRRC42
GH01F053835 1.2 ENCODE 31.8 -598.5 -598521 4.1 CREB3L1 MLX YBX1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D HSPB11 CYB5RL MAGOH PODN ENSG00000230953 LRRC42 SSBP3-AS1 MIR4781 TCEANC2 TMEM59
GH01F052402 1.1 ENCODE 24.2 +834.3 834329 3.2 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MAGOH ENSG00000266993 PRPF38A TXNDC12 ZCCHC11 KTI12 ORC1 PLA2G12AP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAGOH on UCSC Golden Path with GeneCards custom track

Promoters for MAGOH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000165285 210 2000 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for MAGOH Gene

Chromosome:
1
Start:
53,226,892 bp from pter
End:
53,238,610 bp from pter
Size:
11,719 bases
Orientation:
Minus strand

Genomic View for MAGOH Gene

Genes around MAGOH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGOH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGOH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGOH Gene

Proteins for MAGOH Gene

  • Protein details for MAGOH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61326-MGN_HUMAN
    Recommended name:
    Protein mago nashi homolog
    Protein Accession:
    P61326
    Secondary Accessions:
    • B1ARP8
    • B2R5A2
    • O35169
    • P50606
    • Q5SW69

    Protein attributes for MAGOH Gene

    Size:
    146 amino acids
    Molecular mass:
    17164 Da
    Quaternary structure:
    • Heterodimer with RBM8A. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A. Interacts with PYM1; the interaction is direct and dissociates the EJC from spliced mRNAs. Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for MAGOH Gene

    Alternative splice isoforms for MAGOH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGOH Gene

Post-translational modifications for MAGOH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGOH Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MAGOH

No data available for DME Specific Peptides for MAGOH Gene

Domains & Families for MAGOH Gene

Gene Families for MAGOH Gene

Protein Domains for MAGOH Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGOH Gene

Graphical View of Domain Structure for InterPro Entry

P61326

UniProtKB/Swiss-Prot:

MGN_HUMAN :
  • Belongs to the mago nashi family.
Family:
  • Belongs to the mago nashi family.
genes like me logo Genes that share domains with MAGOH: view

Function for MAGOH Gene

Molecular function for MAGOH Gene

GENATLAS Biochemistry:
Drosophila Mago Nashi (grandchildless) homolog,determining the localization and fate of germ cells during Drosophila germ plasm development,expressed ubiquitously adult tissues
UniProtKB/Swiss-Prot Function:
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.

Gene Ontology (GO) - Molecular Function for MAGOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 10662555
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MAGOH: view
genes like me logo Genes that share phenotypes with MAGOH: view

Animal Models for MAGOH Gene

MGI Knock Outs for MAGOH:

Animal Model Products

miRNA for MAGOH Gene

miRTarBase miRNAs that target MAGOH

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAGOH Gene

Localization for MAGOH Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGOH Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGOH gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for MAGOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAGOH: view

Pathways & Interactions for MAGOH Gene

genes like me logo Genes that share pathways with MAGOH: view

Gene Ontology (GO) - Biological Process for MAGOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 22203037
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with MAGOH: view

No data available for SIGNOR curated interactions for MAGOH Gene

Transcripts for MAGOH Gene

Unigene Clusters for MAGOH Gene

Mago-nashi homolog, proliferation-associated (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGOH Gene

No ASD Table

Relevant External Links for MAGOH Gene

GeneLoc Exon Structure for
MAGOH
ECgene alternative splicing isoforms for
MAGOH

Expression for MAGOH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAGOH Gene

Protein differential expression in normal tissues from HIPED for MAGOH Gene

This gene is overexpressed in Pancreas (24.5) and Fetal ovary (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAGOH Gene



Protein tissue co-expression partners for MAGOH Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGOH Gene:

MAGOH

SOURCE GeneReport for Unigene cluster for MAGOH Gene:

Hs.421576

mRNA Expression by UniProt/SwissProt for MAGOH Gene:

P61326-MGN_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MAGOH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAGOH Gene

Orthologs for MAGOH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAGOH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100613301 34
  • 100 (n)
MAGOH 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 99 (a)
ManyToMany
-- 35
  • 98 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia MAGOH 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAGOH 34 35
  • 95.66 (n)
dog
(Canis familiaris)
Mammalia MAGOH 34
  • 95.66 (n)
mouse
(Mus musculus)
Mammalia Magoh 34 16 35
  • 91.1 (n)
rat
(Rattus norvegicus)
Mammalia Magoh 34
  • 90.18 (n)
chicken
(Gallus gallus)
Aves MAGOH 35
  • 99 (a)
OneToMany
MAGOH2 34
  • 83.56 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 99 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64274 34
zebrafish
(Danio rerio)
Actinopterygii magoh 35
  • 97 (a)
OneToMany
Dr.13517 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4136 34
fruit fly
(Drosophila melanogaster)
Insecta mago 36 35
  • 91 (a)
worm
(Caenorhabditis elegans)
Secernentea mag-1 35
  • 76 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1607 34
barley
(Hordeum vulgare)
Liliopsida Hv.275 34
wheat
(Triticum aestivum)
Liliopsida Ta.10145 34
corn
(Zea mays)
Liliopsida Zm.4796 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14815 34
Species where no ortholog for MAGOH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for MAGOH Gene

ENSEMBL:
Gene Tree for MAGOH (if available)
TreeFam:
Gene Tree for MAGOH (if available)

Paralogs for MAGOH Gene

Paralogs for MAGOH Gene

(1) SIMAP similar genes for MAGOH Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MAGOH Gene

genes like me logo Genes that share paralogs with MAGOH: view

Variants for MAGOH Gene

Sequence variations from dbSNP and Humsavar for MAGOH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10788949 -- 53,230,379(+) TATCC(C/T)GATTT intron-variant
rs111403640 -- 53,239,922(+) GTCTC(C/G)AACTC intron-variant, upstream-variant-2KB
rs111408142 -- 53,234,901(+) AGAAC(A/G)GAGAA intron-variant
rs111645464 -- 53,238,577(+) AGGGG(C/T)TCCTT upstream-variant-2KB, utr-variant-5-prime
rs111892971 -- 53,230,117(+) GTGCT(C/T)TGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGOH Gene

Variant ID Type Subtype PubMed ID
nsv829871 CNV loss 17160897
nsv1011750 CNV gain 25217958
nsv1001535 CNV gain 25217958
esv2422213 CNV duplication 17116639

Variation tolerance for MAGOH Gene

Residual Variation Intolerance Score: 50.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGOH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGOH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGOH Gene

Disorders for MAGOH Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGOH Gene - From: DISEASES

Disorder Aliases PubMed IDs
waardenburg syndrome, type 4a
  • waardenburg's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MAGOH in MalaCards View complete list of genes associated with diseases

Relevant External Links for MAGOH

Genetic Association Database (GAD)
MAGOH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGOH
genes like me logo Genes that share disorders with MAGOH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGOH Gene

Publications for MAGOH Gene

  1. The mammalian homologue of mago nashi encodes a serum-inducible protein. (PMID: 9479507) Zhao X.F. … Aplan P.D. (Genomics 1998) 2 3 4 22 64
  2. MAGOH interacts with a novel RNA-binding protein. (PMID: 10662555) Zhao X.F. … Aplan P.D. (Genomics 2000) 3 4 22 64
  3. Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. (PMID: 22203037) Michelle L. … Chabot B. (Mol. Cell. Biol. 2012) 3 4 64
  4. Disassembly of exon junction complexes by PYM. (PMID: 19410547) Gehring N.H. … Hentze M.W. (Cell 2009) 3 4 64
  5. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. (PMID: 18026120) Diem M.D. … Dreyfuss G. (Nat. Struct. Mol. Biol. 2007) 3 4 64

Products for MAGOH Gene

Sources for MAGOH Gene

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