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MAGOH Gene

protein-coding   GIFtS: 57

GC01M053404
mago-nashi homolog, proliferation-associated (Drosophila)
(Previous names: mago-nashi (Drosophila) homolog, proliferation-associated )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MAGOHA 1, 2
OTTHUMP00000010485 2
Descriptions
mago-nashi (Drosophila) homolog, proliferation-associated 1
mago-nashi homolog 2
mago-nashi homolog, proliferation-associated (Drosophila) 2
External Ids
HGNC: 68151
Entrez Gene: 41162
UniProtKB: P613263
Ensembl: ENSG000001623857
Search outside databases for aliases for MAGOH gene

Previous GC identifers: GC01M053327 GC01M052581 GC01M053051 GC01M053062

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for MAGOH:
Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with
defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi
homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed
ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.
[provided by RefSeq]

UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
Function: Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway

Gene Wiki entry for MAGOH

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MAGOH gene  

Entrez Gene cytogenetic band: 1p34-p33   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

MAGOH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M053404:     (about GC identifiers)

Start:
53,465,152 bp from pter
End:
53,476,795 bp from pter
Size:
11,644 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MGN_HUMAN, P61326 (See protein sequence)
Recommended Name: Protein mago nashi homolog  
Size: 146 amino acids; 17164 Da
Subunit: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29,
CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1,
HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604,
LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6,
PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2,
SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2,
SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Interacts with RBM8A and is part of the
exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2 and
THOC4. Remains associated with the mRNA after its export to the cytoplasm and require translation
of the mRNA for removal. Interacts with WIBG/PYM; the interaction is direct and leads to
dissociate the EJC from spliced mRNAs
Subcellular location: Nucleus (By similarity)
PDB structures from and Proteopedia :
1P27 (3D)    2HYI (3D)    2J0Q (3D)    2J0S (3D)    3EX7 (3D)    
Secondary accessions: O35169 P50606 Q5SW69

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002361.1  

    ENSEMBL proteins: 
    ENSP00000360521 ENSP00000360525 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (MAGOH)
    Human Recombinant Proteins from Abnova (MAGOH)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus NAS--
    GO:0005681 spliceosome IEA--
    About this table

    Antibodies for MAGOH: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for MAGOH
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (MAGOH), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (MAGOH)
    Novus Biologicals Antibodies for MAGOH

    Assays for MAGOH: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR004023 Mago_nashi


       GeneDecks  MAGOH for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P61326

    ProtoNet protein and cluster: P61326

    UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
    Similarity: Belongs to the mago nashi family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MAGOH)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MAGOH)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002370

                  Applied Biosystems Silencer® siRNAs for MAGOH

                  Sigma-Aldrich siRNA for MAGOH  
                         Sigma-Aldrich shRNA for MAGOH  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002370
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002370
                                     untagged cDNA clone in CMV expression vector: NM_002370 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002370

    UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
    Function: Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway

    Genatlas biochemistry entry for MAGOH:
    Drosophila Mago Nashi (grandchildless) homolog,determining the localization and fate of germ cells
    during Drosophila germ plasm development,expressed ubiquitously adult tissues

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723 RNA binding IEA--
    GO:0005515 protein binding IPI10662555 14730019 14973490 17353931
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  MAGOH 


    5/109 Interacting proteins for MAGOH (ENSP000003605253 P613261, 2) via UniProtKB, MINT, and/or STRING (see all 109 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASC3O152341STRING (score=.965) EBI-299134, EBI-299118
    EIF4A3P389191STRING (score=.965) EBI-299134, EBI-299104
    RBM8AQ9Y5S91STRING (score=.999) EBI-299134, EBI-447231
    YWHAQP273481, 2EBI-299134, EBI-359854 MINT-50369 EBI-299134, EBI-359854 MINT-50369
    YWHAQP273481, 2EBI-299134, EBI-359854 MINT-50369 EBI-299134, EBI-359854 MINT-50369
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA--
    GO:0000398 nuclear mRNA splicing, via spliceosome EXP12226669
    GO:0006810 transport IEA--
    GO:0008380 RNA splicing IEA--
    GO:0051028 mRNA transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for MAGOH

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MAGOH)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MAGOH)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002370

                  Sigma-Aldrich siRNA for MAGOH  
                         Sigma-Aldrich shRNA for MAGOH  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002370  

    REFSEQ mRNAs for MAGOH gene: 

    NM_002370.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002370  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002370
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002370
                                     untagged cDNA clone in CMV expression vector: NM_002370 

    Additional cDNA sequence: 

    AF035940.1 AF067173.1 AF086246.1 AK297895.1 AK312113.1 BC018211.1 

    9 DOTS entries:

    DT.109824  DT.85104220  DT.40273016  DT.102826938  DT.86852796  DT.95202717  DT.95262307  DT.95262313 
    DT.121327765 

    24/78 AceView cDNA sequences (see all 78 ):

    AA489775 BM808411 BX283982 BC018211 CF130293 C01289 BM824432 BE048136 
    AF086246 AI632611 BM770941 AA357603 AA504979 BM911523 AI863283 AA314669 
    BM914866 BM997952 BU619340 BM794469 BM771332 AI821560 BF448103 BG429919 

    highest scoring ESTs for MAGOH:

    AF035940 AA307757 AA314669 AA314742 AF067173 AI632611 AV756132 AW104858 AW955286 BC018211 

    Unigene Cluster for MAGOH:

    Mago-nashi homolog, proliferation-associated (Drosophila)
    Hs.421576  [show with all ESTs]
    Unigene Representative Sequence: BM914866


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000371466  ENST00000371470  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    MAGOH expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for MAGOH

    1 / 2 / 3

    5 probe-sets matching MAGOH gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40036_at2, 3 U95-A 4 1.00 0.73 1.00 1.00 AF035940 1.00 1.00 1.00 1

    210092_at2, 3 U133-A 1 1.00 1.00 -- -- AF067173 0.80 1.00 0.91 1

    210093_s_at2, 3 U133-A 2 1.00 0.95 -- -- AF067173 0.80 1.00 0.91 1

    210092_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    210093_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    GeneDecks  MAGOH for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGGGGTGGGT

    SOURCE GeneReport for Unigene cluster: Hs.421576

    Expression variation in blood from EXPOLDB for MAGOH

    UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
    Tissue specificity: Ubiquitous

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for MAGOH gene from 5/18 species (see all 18 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MAGOH1   -- mago-nashi homolog, proliferation-associated (Drosophila) 95.66(n)
    100(a)
    479562  XM_536702.2  XP_536702.1 
    chimpanzee
    (Pan troglodytes)
    MAGOH1   -- mago-nashi homolog, proliferation-associated (Drosophila) 83.11(n)
    91.1(a)
    736868  XM_001136983.1  XP_001136983.1 
    cow
    (Bos taurus)
    MAGOH1   -- mago-nashi homolog, proliferation-associated (Drosophila) 95.66(n)
    100(a)
    505417  NM_001034245.1  NP_001029417.1 
    rat
    (Rattus norvegicus)
    Magoh1   -- mago-nashi homolog, proliferation-associated (Drosophila) 90.18(n)
    100(a)
    298385  XM_216485.4  XP_216485.1 
    mouse
    (Mus musculus)
    Magoh1, 5 4 (51.30 cM)5
    mago-nashi homolog, proliferation-associated (Drosophila)1, 5 91.1(n)1
    100(a)1
    171491  NM_010760.21  NP_034890.11 
     AF0078625  AF0359395  (see all 9)
    About this table        Species with no ortholog for MAGOH

    ENSEMBL Gene Tree for MAGOH
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for MAGOH gene
    MAGOHB2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/49 NCBI SNPs in MAGOH are shown (see all 49 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 42)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs121368371,2
    A,C,F,H53465076(+) TATCTA/GGAGAG 1 -- ng514Minor allele frequency- G:0.31EU EA WA 412
    rs177853701,2
    C,F,H53477762(+) CACTCA/TTCTAA 1 -- ng317Minor allele frequency- T:0.14NA EU EA WA 558
    rs121334641,2
    A,F,H53465025(+) ATTTTT/AAAAAC 1 -- ng514Minor allele frequency- A:0.30EU EA WA 418
    rs22976561,2
    A,C,F,H,O53474169(+) TTGTCA/GAATCA 1 -- int18Minor allele frequency- G:0.47EA NA EU WA 2032
    rs66760031,2
    A,C,F,H53469372(+) CTGTTG/TTTATT 1 -- int18Minor allele frequency- T:0.46EU EA WA 792
    rs107889491,2
    A,C,F,H53468639(+) TATCCC/TGATTT 1 -- int112Minor allele frequency- T:0.32EU EA WA NA 1046
    rs22750871,2
    A,C,F,H53466976(+) AAAAAT/CAATTT 1 -- int15Minor allele frequency- C:0.42EA EU WA 1544
    rs66736921,2
    A,C,F,H53469727(+) AGTCTA/GTATTC 1 -- int15Minor allele frequency- G:0.42EU WA NA 350
    rs66709991,2
    A,C,F,H53465678(+) agataG/Ttaata 1 -- int17Minor allele frequency- T:0.34EU EA WA NA 554
    rs120823051,2
    C,F,H53466215(+) CAACAT/GTTGCC 1 -- int18Minor allele frequency- G:0.11EU EA WA 836
    About this table

    HapMap Linkage Disequilibrium images for MAGOH (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 602603

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/25 PubMed articles for MAGOH gene (see all 25 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4116 HGNC: 6815 AceView: MAGOH Ensembl:ENSG00000162385 euGenes: HUgn4116
    ECgene: MAGOH H-InvDB: MAGOH
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for MAGOH:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for MAGOH Antibodies for MAGOH
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for MAGOH Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for MAGOH

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