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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGOH Gene

protein-coding   GIFtS: 61
GCID: GC01M053692

Mago-Nashi Homolog, Proliferation-Associated (Drosophila)

(Previous names: mago-nashi (Drosophila) homolog, proliferation-associated)
  Search for MAGOH
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mago-Nashi Homolog, Proliferation-Associated (Drosophila)1 2
MAGOHA2 3
Mago-Nashi (Drosophila) Homolog, Proliferation-Associated1
MAGOH12
Protein Mago Nashi Homolog2

External Ids:    HGNC: 68151   Entrez Gene: 41162   Ensembl: ENSG000001623857   OMIM: 6026035   UniProtKB: P613263   

Export aliases for MAGOH gene to outside databases

Previous GC identifers: GC01M053327 GC01M052581 GC01M053051 GC01M053062 GC01M053404 GC01M053465 GC01M051808


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAGOH Gene:
Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm
assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA
expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by
serum stimulation of quiescent fibroblasts. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAGOH Gene: 
MAGOH (mago-nashi homolog, proliferation-associated (Drosophila)) is a protein-coding gene. Among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. GO annotations related to this gene include protein binding and RNA binding. An important paralog of this gene is MAGOHB.

UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
Function: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction
on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear
and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during
subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages
of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby
influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA
localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Remains associated with the mRNA
after its export to the cytoplasm and require translation of the mRNA for removal. The heterodimer MAGOH-RBM8A
interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to
the ribosomal 48S preinitiation complex

Gene Wiki entry for MAGOH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGOH gene promoter:
         SRF   SRF (504 AA)   FOXO3   XBP-1   CUTL1   E47   FOXO3b   COMP1   FOXO3a   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGOH promoter sequence
   Search SABiosciences Chromatin IP Primers for MAGOH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGOH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

MAGOH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGOH gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M053692:  view genomic region     (about GC identifiers)

Start:
53,692,564 bp from pter      End:
53,704,282 bp from pter
Size:
11,719 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MGN_HUMAN, P61326 (See protein sequence)
Recommended Name: Protein mago nashi homolog  
Size: 146 amino acids; 17164 Da
Subunit: Heterodimer with RBM8A. Part of the EJC core complex that contains CASC3, EIF4A3, MAGOH and RBM8A. Found
in a mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3, EIF4A3, MAGOH,
NCBP1, NCBP2, PNN, RBM8A, RNPS1, SRRM1, NXF1, SAP18, UPF3B, UPF2 and ALYREF/THOC4. Interacts with WIBG/PYM; the
interaction is direct and leads to dissociate the EJC from spliced mRNAs. Identified in the spliceosome C complex
Subcellular location: Nucleus. Nucleus speckle. Cytoplasm. Note=Detected in granule-like structures in the
dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles
6 PDB 3D structures from and Proteopedia for MAGOH:
1P27 (3D)        2HYI (3D)        2J0Q (3D)        2J0S (3D)        2XB2 (3D)        3EX7 (3D)    
Secondary accessions: B2R5A2 O35169 P50606 Q5SW69

Explore the universe of human proteins at neXtProt for MAGOH: NX_P61326

Explore proteomics data for MAGOH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61326

  • MAGOH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAGOH Protein Expression
    REFSEQ proteins: NP_002361.1  
    ENSEMBL proteins: 
     ENSP00000360525   ENSP00000360521  
    Reactome Protein details: P61326
    Human Recombinant Protein Products for MAGOH: 
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MAGOH
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MAGOH
    GenScript Custom Purified and Recombinant Proteins Services for MAGOH
    Novus Biologicals MAGOH Proteins
    Novus Biologicals MAGOH Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MAGOH
    Cloud-Clone Corp. Proteins for MAGOH 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0016607nuclear speck IEA--
    GO:0035145exon-exon junction complex IDA16601204

    MAGOH for ontologies           About GeneDecksing



    MAGOH Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAGOH
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    Novus Biologicals MAGOH Antibodies
    Abcam antibodies for MAGOH
    Cloud-Clone Corp. Antibodies for MAGOH 
    ThermoFisher Antibodies for MAGOH
    LSBio Antibodies in human, mouse, rat for MAGOH 

    Assay Products for MAGOH: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAGOH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAGOH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAGOH 
    Cloud-Clone Corp. CLIAs for MAGOH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR004023 Mago_nashi

    Graphical View of Domain Structure for InterPro Entry P61326

    ProtoNet protein and cluster: P61326

    UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
    Similarity: Belongs to the mago nashi family


    MAGOH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MGN_HUMAN, P61326
    Function: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction
    on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear
    and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during
    subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages
    of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby
    influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA
    localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Remains associated with the mRNA
    after its export to the cytoplasm and require translation of the mRNA for removal. The heterodimer MAGOH-RBM8A
    interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to
    the ribosomal 48S preinitiation complex

         Genatlas biochemistry entry for MAGOH:
    Drosophila Mago Nashi (grandchildless) homolog,determining the localization and fate of germ cells during
    Drosophila germ plasm development,expressed ubiquitously adult tissues

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI10662555
         
    MAGOH for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAGOH:
     Cell division defect  Decreased cell number, increas  Decreased viability of wild-ty  Increased number of mitotic ce 
     Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Magoh):
     cellular  growth/size  mortality/aging  nervous system  pigmentation 

    MAGOH for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAGOH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAGOH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAGOH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAGOH 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAGOH
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MAGOH
    SwitchGear 3'UTR luciferase reporter plasmidMAGOH 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MAGOH

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAGOH (see all 7)
    OriGene ORF clones in mouse, rat for MAGOH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAGOH (NM_002370)
    Sino Biological Human cDNA Clone for MAGOH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGOH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGOH
    Sirion Biotech Customized lentivirus for stable overexpression of MAGOH 
                         Customized lentivirus expression plasmids for stable overexpression of MAGOH 

    Cell Line
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    Search LifeMap BioReagents cell lines for MAGOH
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGOH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAGOH About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    Spliceosome0.31
    mRNA Splicing - Major Pathway0.82
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    3Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    4Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.85
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.85
    5Viral mRNA Translation
    Nonsense-Mediated Decay0.84
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/18        Reactome Pathways for MAGOH (see all 18)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    Nonsense-Mediated Decay
    Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    RNA Polymerase II Transcription


    3         Kegg Pathways  (Kegg details for MAGOH):
        RNA transport
    mRNA surveillance pathway
    Spliceosome


    MAGOH for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAGOH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for MAGOH (P613261, 2, 3 ENSP000003605254) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBM8AQ9Y5S91, 2, 3, ENSP000003330014EBI-299134,EBI-447231 MINT-8337860 I2D: score=5 STRING: ENSP00000333001
    IPO13O948292, 3, ENSP000003614184MINT-8109916 MINT-8109339 I2D: score=4 STRING: ENSP00000361418
    CASC3O152341, 3, ENSP000002646454EBI-299134,EBI-299118 I2D: score=1 STRING: ENSP00000264645
    EIF4A3P389191, 3, ENSP000002693494EBI-299134,EBI-299104 I2D: score=3 STRING: ENSP00000269349
    YWHAQP273482, 3, ENSP000002380814MINT-50369 I2D: score=5 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006406mRNA export from nucleus TAS--

    MAGOH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAGOH (MGN)

    Search CenterWatch for drugs/clinical trials and news about MAGOH / MGN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAGOH gene: 
    NM_002370.3  

    Unigene Cluster for MAGOH:

    Mago-nashi homolog, proliferation-associated (Drosophila)
    Hs.421576  [show with all ESTs]
    Unigene Representative Sequence: BM914866
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371470(uc001cvf.2 uc010ont.2) ENST00000371466 ENST00000495868
    ENST00000462941
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMAGOH 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: MAGOH (NM_002370)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGOH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGOH
    Sirion Biotech Customized lentivirus for stable overexpression of MAGOH 
                         Customized lentivirus expression plasmids for stable overexpression of MAGOH 
    Primer
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    OriGene qPCR primer pairs and template standards for MAGOH
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGOH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGOH

    Additional mRNA sequence: 

    AF035940.1 AF067173.1 AF086246.1 AK297895.1 AK312113.1 BC018211.1 

    9 DOTS entries:

    DT.109824  DT.85104220  DT.40273016  DT.102826938  DT.86852796  DT.95202717  DT.95262307  DT.95262313 
    DT.121327765 

    24/78 AceView cDNA sequences (see all 78):

    C01289 AI863283 BF448103 BC018211 AA489775 BM771332 BM770941 AI632611 
    BX283982 BM824432 AA314669 BE048136 AA357603 CF130293 BM914866 BU619340 
    AF086246 BM911523 BM808411 BM997952 BM794469 AA504979 AI821560 AA314742 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGOH expression in normal human tissues (normalized intensities)      MAGOH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGGTGGGT
    MAGOH Expression
    About this image


    MAGOH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             bone marrow cd34+   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See MAGOH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAGOH

    SOURCE GeneReport for Unigene cluster: Hs.421576

    UniProtKB/Swiss-Prot: MGN_HUMAN, P61326
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for MAGOH
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGOH
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGOH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGOH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAGOH gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Magoh1 , 5 mago-nashi homolog, proliferation-associated (Drosophila)1, 5 91.1(n)1
    100(a)1
      4 (50.18 cM)5
    171491  NM_010760.21  NP_034890.11 
     1078797555 
    chicken
    (Gallus gallus)
    Aves MAGOH1 mago-nashi homolog, proliferation-associated (Drosophila) 83.56(n)
    99.32(a)
      374226  NM_204325.1  NP_989656.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    99(a)
    1 → many
    4(115050211-115054192)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC642742 hypothetical protein MGC64274 81.72(n)    AF007860.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.135172 Transcribed sequence with strong similarity to protein more 80.86(n)    BI865687.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mago1 , 3 protein localization3
    mago nashi1
    91(a)3
    71.79(n)1
    91.61(a)1
      57C23
    374021  NM_057288.31  NP_476636.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mag-11 Protein MAG-1 65.51(n)
    80.56(a)
      173073  NM_060624.5  NP_493025.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.16072 Vitis vinifera transcribed sequence with moderate similarity more 77.2(n)    CB982464.1 
    rice
    (Oryza sativa)
    Liliopsida CF291311.12   -- 76.28(n)    CF291311.1 


    ENSEMBL Gene Tree for MAGOH (if available)
    TreeFam Gene Tree for MAGOH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGOH gene
    MAGOHB2  
    1 SIMAP similar gene for MAGOH using alignment to 2 protein entries:     MGN_HUMAN (see all proteins):
    MAGOHB

    MAGOH for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MAGOH
    PGOHUM00000236920 PGOHUM00000235219


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/188 SNPs in MAGOH are shown (see all 188)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830810111,2
    --53692077(+) CCAAGC/TGATTT 1 -- int10--------
    rs1448917741,2
    C--53692248(+) CACCA-/CCATCT 1 -- int10--------
    rs1458557941,2
    C--53692297(+) GGGTC-/CAAA  
            
    CATTG
    1 -- int10--------
    rs1450466311,2
    --53692357(+) TTTCCA/CTTGTA 1 -- int10--------
    rs1170276471,2
    F--53692407(+) TCTCAA/GTATGG 1 -- int11Minor allele frequency- G:0.03EA 120
    rs1388291451,2
    --53692430(+) CCACTA/GTATTT 1 -- int10--------
    rs121334641,2
    C,F,A,H--53692437(+) ATTTTT/AAAAAC 1 -- int19Minor allele frequency- A:0.29NS EA NA WA 780
    rs121368371,2
    C,F,A,H--53692488(+) TATCTA/GGAGAG 1 -- int118Minor allele frequency- G:0.23NS EA NA WA 2230
    rs1870972791,2
    C--53692674(+) AAAATG/TTTCTA 1 -- ut310--------
    rs1995558081,2
    --53692682(+) CTACTC/TCCACC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MAGOH (53692564 - 53704282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MAGOH:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422213CNV Duplication17116639
    nsv829871CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MAGOH for disorders           About MalaCards
    OMIM gene information: 602603    OMIM disorders: --


    MAGOH for disorders           About GeneDecksing

    Genetic Association Database (GAD): MAGOH

    Export disorders for MAGOH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGOH gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with MAGOH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The mammalian homologue of mago nashi encodes a serum-inducible protein. (PubMed id 9479507)1, 2, 3, 9 Zhao X.F....Aplan P.D. (1998)
    2. MAGOH interacts with a novel RNA-binding protein. (PubMed id 10662555)1, 2, 9 Zhao X.F.... Aplan P.D. (2000)
    3. Disassembly of exon junction complexes by PYM. (PubMed id 19410547)1, 2 Gehring N.H.... Hentze M.W. (2009)
    4. PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs. (PubMed id 18026120)1, 2 Diem M.D.... Dreyfuss G. (2007)
    5. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. (PubMed id 16931718)1, 2 Andersen C.B....Andersen G.R. (2006)
    6. The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. (PubMed id 16923391)1, 2 Bono F.... Conti E. (2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Exon-junction complex components specify distinct routes of nonsense- mediated mRNA decay with differential cofactor requirements. (PubMed id 16209946)1, 2 Gehring N.H.... Kulozik A.E. (2005)
    9. The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. (PubMed id 16170325)1, 2 Ballut L....Le Hir H. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4116 HGNC: 6815 AceView: MAGOH Ensembl:ENSG00000162385 euGenes: HUgn4116
    ECgene: MAGOH Kegg: 4116 H-InvDB: MAGOH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAGOH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAGOH gene:
    Search GeneIP for patents involving MAGOH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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