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Aliases for MAGOH Gene

Aliases for MAGOH Gene

  • Mago-Nashi Homolog, Proliferation-Associated (Drosophila) 2 3
  • MAGOHA 3 4
  • Mago-Nashi (Drosophila) Homolog, Proliferation-Associated 2
  • Protein Mago Nashi Homolog 3
  • MAGOH1 3

External Ids for MAGOH Gene

Summaries for MAGOH Gene

Entrez Gene Summary for MAGOH Gene

  • Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGOH Gene

MAGOH (Mago-Nashi Homolog, Proliferation-Associated (Drosophila)) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include RNA binding. An important paralog of this gene is MAGOHB.

UniProtKB/Swiss-Prot for MAGOH Gene

  • Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.

Gene Wiki entry for MAGOH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGOH Gene

Genomics for MAGOH Gene

Genomic Location for MAGOH Gene

Start:
53,226,892 bp from pter
End:
53,238,610 bp from pter
Size:
11,719 bases
Orientation:
Minus strand

Genomic View for MAGOH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGOH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGOH Gene

Regulatory Elements for MAGOH Gene

Proteins for MAGOH Gene

  • Protein details for MAGOH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61326-MGN_HUMAN
    Recommended name:
    Protein mago nashi homolog
    Protein Accession:
    P61326
    Secondary Accessions:
    • B1ARP8
    • B2R5A2
    • O35169
    • P50606
    • Q5SW69

    Protein attributes for MAGOH Gene

    Size:
    146 amino acids
    Molecular mass:
    17164 Da
    Quaternary structure:
    • Heterodimer with RBM8A. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A. Interacts with WIBG/PYM; the interaction is direct and dissociates the EJC from spliced mRNAs. Identified in the spliceosome C complex.

    Three dimensional structures from OCA and Proteopedia for MAGOH Gene

    Alternative splice isoforms for MAGOH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGOH Gene

Proteomics data for MAGOH Gene at MOPED

Post-translational modifications for MAGOH Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys16 and Lys41

Other Protein References for MAGOH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGOH Gene

Domains for MAGOH Gene

Protein Domains for MAGOH Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MGN_HUMAN
Family:
  • Belongs to the mago nashi family.:
    • P61326
genes like me logo Genes that share domains with MAGOH: view

No data available for Gene Families for MAGOH Gene

Function for MAGOH Gene

Molecular function for MAGOH Gene

GENATLAS Biochemistry: Drosophila Mago Nashi (grandchildless) homolog,determining the localization and fate of germ cells during Drosophila germ plasm development,expressed ubiquitously adult tissues
UniProtKB/Swiss-Prot Function: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator WIBG/PYM leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly.

Gene Ontology (GO) - Molecular Function for MAGOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10662555
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MAGOH: view
genes like me logo Genes that share phenotypes with MAGOH: view

miRNA for MAGOH Gene

miRTarBase miRNAs that target MAGOH

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAGOH Gene

Localization for MAGOH Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGOH Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Detected in granule-like structures in the dendroplasm (By similarity). Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGOH Gene COMPARTMENTS Subcellular localization image for MAGOH gene
Compartment Confidence
nucleus 5
cytosol 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for MAGOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0016607 nuclear speck IEA --
GO:0035145 exon-exon junction complex IDA 16601204
genes like me logo Genes that share ontologies with MAGOH: view

Pathways for MAGOH Gene

genes like me logo Genes that share pathways with MAGOH: view

Gene Ontology (GO) - Biological Process for MAGOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 22203037
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
genes like me logo Genes that share ontologies with MAGOH: view

Transcripts for MAGOH Gene

Unigene Clusters for MAGOH Gene

Mago-nashi homolog, proliferation-associated (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGOH Gene

No ASD Table

Relevant External Links for MAGOH Gene

GeneLoc Exon Structure for
MAGOH
ECgene alternative splicing isoforms for
MAGOH

Expression for MAGOH Gene

mRNA expression in normal human tissues for MAGOH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGOH Gene

SOURCE GeneReport for Unigene cluster for MAGOH Gene Hs.421576

mRNA Expression by UniProt/SwissProt for MAGOH Gene

P61326-MGN_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with MAGOH: view

Orthologs for MAGOH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAGOH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100613301 36
  • 100 (n)
  • 100 (a)
MAGOH 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAGOH 36
  • 95.66 (n)
  • 100 (a)
MAGOH 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAGOH 36
  • 95.66 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Magoh 36
  • 91.1 (n)
  • 100 (a)
Magoh 16
Magoh 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAGOH 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 99 (a)
ManyToMany
-- 37
  • 98 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Magoh 36
  • 90.18 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves MAGOH 37
  • 99 (a)
OneToMany
MAGOH2 36
  • 83.56 (n)
  • 99.32 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 99 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64274 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4136 36
zebrafish
(Danio rerio)
Actinopterygii Dr.13517 36
magoh 37
  • 97 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mago 37
  • 88 (a)
OneToMany
mago 38
  • 91 (a)
worm
(Caenorhabditis elegans)
Secernentea mag-1 37
  • 76 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1607 36
barley
(Hordeum vulgare)
Liliopsida Hv.275 36
corn
(Zea mays)
Liliopsida Zm.4796 36
wheat
(Triticum aestivum)
Liliopsida Ta.10145 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14815 36
Species with no ortholog for MAGOH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for MAGOH Gene

ENSEMBL:
Gene Tree for MAGOH (if available)
TreeFam:
Gene Tree for MAGOH (if available)

Paralogs for MAGOH Gene

Paralogs for MAGOH Gene

Selected SIMAP similar genes for MAGOH Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MAGOH Gene

genes like me logo Genes that share paralogs with MAGOH: view

Variants for MAGOH Gene

Sequence variations from dbSNP and Humsavar for MAGOH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2275087 -- 53,228,716(+) AAAAA(C/T)AATTT intron-variant
rs2297656 -- 53,235,909(+) TTGTC(A/G)AATCA intron-variant
rs6588472 -- 53,234,498(+) cctcc(C/T)aagta intron-variant
rs6670999 -- 53,227,418(+) AGATA(G/T)TAATA intron-variant
rs6671231 -- 53,234,845(+) GTGGT(A/T)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGOH Gene

Variant ID Type Subtype PubMed ID
esv2422213 CNV Duplication 17116639
nsv829871 CNV Loss 17160897

Relevant External Links for MAGOH Gene

HapMap Linkage Disequilibrium report
MAGOH

Disorders for MAGOH Gene

Relevant External Links for MAGOH

Genetic Association Database (GAD)
MAGOH
genes like me logo Genes that share disorders with MAGOH: view

No data available for UniProtKB/Swiss-Prot for MAGOH Gene

Publications for MAGOH Gene

  1. The mammalian homologue of mago nashi encodes a serum-inducible protein. (PMID: 9479507) Zhao X.F. … Aplan P.D. (Genomics 1998) 2 3 4 23
  2. MAGOH interacts with a novel RNA-binding protein. (PMID: 10662555) Zhao X.F. … Aplan P.D. (Genomics 2000) 3 4 23
  3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. A novel mode of RBD-protein recognition in the Y14-Mago complex. (PMID: 12730685) Fribourg S. … Conti E. (Nat. Struct. Biol. 2003) 3 4

Products for MAGOH Gene

Sources for MAGOH Gene

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