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MAGIX Gene

protein-coding GIFtS: 43

GC0XP048907

MAGI family member, X-linked
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ21687 ^¹, ²
JM10 ^¹, ²
MGC138889 ^²
PDZX ^¹, ²

Descriptions
MAGI family member, X-linked ^²
PDZ domain containing protein ^²
PDZ domain containing, X chromosome ^²

External Ids
HGNC: 30006¹
Entrez Gene: 79917²
UniProtKB: Q9H6Y5³
Ensembl: ENSG00000017621⁷

Search outside databases for aliases for MAGIX gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.23

MAGIX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP048907: (about GC identifiers)

Start:	48,906,005 bp from pter
End:	48,911,766 bp from pter
Size:	5,762 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_079573.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MAGIX_HUMAN, Q9H6Y5 (See protein sequence)

Recommended Name: PDZ domain-containing protein MAGIX

Size: 334 amino acids; 35217 Da

Sequence caution: Sequence=AAI14944.1; Type=Frameshift; Positions=317;

PDB structures from and Proteopedia :

2DJT (3D)

Secondary accessions: A6XND4 A8MSX9 Q14C81

Alternative splicing: 3 isoforms: Q9H6Y5-1 Q9H6Y5-2 Q9H6Y5-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001093150.1 NP_001093151.1 NP_001093152.1 NP_079135.2

ENSEMBL proteins:

ENSP00000365516 ENSP00000365517 ENSP00000382799

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for MAGIX:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for MAGIX

Assays for MAGIX:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9H6Y5

ProtoNet protein and cluster: Q9H6Y5

1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain

UniProtKB/Swiss-Prot: MAGIX_HUMAN, Q9H6Y5

Similarity: Contains 1 PDZ (DHR) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGIX)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_024859

Applied Biosystems Silencer® siRNAs for MAGIX

Sigma-Aldrich siRNA for MAGIX

Sigma-Aldrich shRNA for MAGIX

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001099680
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001099680
untagged cDNA clones in CMV expression vector (see all 6): AK091332

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024859

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for MAGIX

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGIX

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGIX)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_024859

Sigma-Aldrich siRNA for MAGIX

Sigma-Aldrich shRNA for MAGIX

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001099680 NM_001099681 NM_001099682 NM_024859

REFSEQ mRNAs for MAGIX gene (4 alternative transcripts):

NM_001099680.1 NM_001099681.1 NM_001099682.1 NM_024859.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001099680 NM_001099681 NM_001099682 NM_024859

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001099680
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001099680
                                 untagged cDNA clones in CMV expression vector (see all 6): AK091332

Additional cDNA sequence:

AF147307.1 AK025340.1 AK094251.1 AK096058.1 BC027995.1 BC067800.1 BC114943.1 DQ884401.1

7 DOTS entries:

DT.440895 DT.100685086 DT.427548 DT.95256381 DT.40106796 DT.100743849 DT.100018198

24/63 AceView cDNA sequences (see all 63 ):

AA724788 AV661501 AI300636 BI759240 AI493491 AI884782 BG413572 AI560982

BQ187140 BQ707366 AI802971 AI380333 NM_024859 AI761706 AK094251 AI369342

AI362839 BQ045295 AI215824 AI692385 BQ188957 AV720636 CB306035 AI768110

Unigene Cluster for MAGIX:

MAGI family member, X-linked

Hs.193170 [show with all ESTs]

Unigene Representative Sequence: AK025340

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MAGIX (see all 8 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	·	6e
SP1:											-												-
SP2:					-		-		-		-												-
SP3:					-		-		-		-				-		-
SP4:					-		-		-		-				-		-						-
SP5:															-								-

About this scheme

ECgene alternative splicing isoforms for MAGIX

3 Ensembl transcripts including schematic representations:

ENST00000376338 ENST00000376339 ENST00000399915

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAGIX expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAGIX

¹ / ²

9 probe-sets matching MAGIX gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
61636_at²	U95-C	1	1.00	1.00	0.32	1.01	--	--	--	--	--
44023_at²	U95-B	1	1.00	1.00	0.97	1.00	--	--	--	--	--
234927_s_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
219965_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
222944_s_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
234927_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219965_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1563318_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222944_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCAGGCCGT

SOURCE GeneReport for Unigene cluster: Hs.193170

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAGIX gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	MAGIX¹	--	MAGI family member, X-linked	99(n) 98.87(a)	465627 XM_001141758.1 XP_001141758.1
cow (Bos taurus)	MAGIX¹	--	MAGI family member, X-linked	78.62(n) 69.43(a)	511713 XM_589102.3 XP_589102.3
rat (Rattus norvegicus)	Magix¹	--	MAGI family member, X-linked	71.22(n) 64.29(a)	317379 NM_001014109.1 NP_001014131.1
mouse (Mus musculus)	Magix^{1, 5}	X (1.60 cM)⁵	MAGI family member, X-linked^{1, 5}	72.81(n)¹ 65.62(a)¹	54634¹ NM_018832.2¹ NP_061302.2¹ AF229645⁵ AK077898⁵ (see all 11)

About this table Species with no ortholog for MAGIX

ENSEMBL Gene Tree for MAGIX

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAGIX gene

ENSG00000151276² MAGI2² MAGI3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/47 NCBI SNPs in MAGIX are shown (see all 47 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2091957^1,2	A,C,F,H	48907626(+)	`GAGGGC/AGTGCT`	4	--	ut5¹ int¹		8		EU EA WA	626
	rs12007680^1,2	A,C,F,H	48905839(+)	`GTGGAG/AATTGC`	4	--	ng5¹ tfbs³		4		EU EA WA	416
	rs12007722^1,2	A,C,H	48911236(+)	`AGCTAC/GAGAGA`	4	--	ng3¹ ese³		4		EU EA WA	418
	rs5906744^1,2	C,H	48908200(+)	`GGCACG/ATAGTG`	4	H/R	mis¹ int¹ ese³		4		EU EA WA	410
	rs4824462^1,2	C,H	48909644(+)	`CGCAGC/TTCGCT`	4	L/F	mis¹ ese³		4		EU EA WA	412
	rs5905720^1,2	C,H	48908481(+)	`GGGACG/CTCGTG`	4	V/L	mis¹ ese³		8		EU EA WA	622
	rs5953268^1,2	H	48904310(+)	`CCTATC/TCTGGG`	3	--	ng5¹		4		EU EA WA	412
--	rs4824744^1,2	A	48907078(+)	`CCCTCA/CCCGCT`	4	S/S	syn¹ ng5¹		0	--	--	--	--
--	rs12843494^1,2	C,F	48907996(+)	`GTTAGC/TGTGCT`	4	S/S	syn¹		3		NA	111
--	rs7880193^1,2	C,H	48909255(+)	`TCTCAG/AGGTCA`	4	--	int¹		4		EU EA WA	402

About this table

HapMap Linkage Disequilibrium images for MAGIX (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for MAGIX gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)⁴ Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 79917	HGNC: 30006	AceView: FLJ21687	Ensembl:ENSG00000017621	euGenes: HUgn79917
ECgene: MAGIX	H-InvDB: MAGIX

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for MAGIX
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MAGIX:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAGIX-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAGIX		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MAGIX		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for MAGIX

Search Tocris compounds for MAGIX

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for MAGIX

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MAGIX Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for MAGIX

Summaries
for MAGIX

Genomic Location
for MAGIX

Proteins
for MAGIX

Protein Domains/
Families
for MAGIX

Gene Function
for MAGIX

Pathways & Interactions
for MAGIX

Drugs & Compounds
for MAGIX

Transcripts
for MAGIX

Expression
for MAGIX

Orthologs
for MAGIX

Paralogs
for MAGIX

SNPs/Variants
for MAGIX

Disorders & Mutations
for MAGIX

Medical News
for MAGIX

Publications
for MAGIX

Search for MAGIX

Genome Databases showing MAGIX

Other Databases showing MAGIX

Specialized Databases showing MAGIX

Licensable Technologies
for MAGIX

Services
for MAGIX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAGIX Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor MAGIX

Summariesfor MAGIX

Genomic Locationfor MAGIX

Proteinsfor MAGIX

Protein Domains/Familiesfor MAGIX

Gene Functionfor MAGIX

Pathways & Interactionsfor MAGIX

Drugs & Compoundsfor MAGIX

Transcriptsfor MAGIX

Expression for MAGIX

Orthologsfor MAGIX

Paralogsfor MAGIX

SNPs/Variantsfor MAGIX

Disorders & Mutationsfor MAGIX

Medical Newsfor MAGIX

Publicationsfor MAGIX

Search for MAGIX

Genome Databases showing MAGIX

Other Databases showing MAGIX

Specialized Databases showing MAGIX

Licensable Technologiesfor MAGIX

Servicesfor MAGIX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAGIX

Summaries
for MAGIX

Genomic Location
for MAGIX

Proteins
for MAGIX

Protein Domains/
Families
for MAGIX

Gene Function
for MAGIX

Pathways & Interactions
for MAGIX

Drugs & Compounds
for MAGIX

Transcripts
for MAGIX

Expression
for MAGIX

Orthologs
for MAGIX

Paralogs
for MAGIX

SNPs/Variants
for MAGIX

Disorders & Mutations
for MAGIX

Medical News
for MAGIX

Publications
for MAGIX

Licensable Technologies
for MAGIX

Services
for MAGIX