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Aliases for MAGIX Gene

Aliases for MAGIX Gene

  • MAGI Family Member, X-Linked 2 3 5
  • PDZ Domain Containing, X Chromosome 3
  • PDZ Domain-Containing Protein MAGIX 3
  • JM10 3
  • PDZX 3

External Ids for MAGIX Gene

Previous GeneCards Identifiers for MAGIX Gene

  • GC0XP048907
  • GC0XP049019
  • GC0XP046676

Summaries for MAGIX Gene

GeneCards Summary for MAGIX Gene

MAGIX (MAGI Family Member, X-Linked) is a Protein Coding gene. An important paralog of this gene is MAGI1.

Additional gene information for MAGIX Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGIX Gene

Genomics for MAGIX Gene

Regulatory Elements for MAGIX Gene

Enhancers for MAGIX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH049154 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -6.7 -6684 2 HDGF PKNOX1 ATF1 SIN3A ZNF766 GLIS2 ZNF143 FOS KLF7 ATF7 ENSG00000270012 FTSJ1 GPKOW HDAC6 MAGIX GATA1 RN7SL262P LOC105373195
GH0XH048789 1.1 FANTOM5 ENCODE dbSUPER 1.9 -372.8 -372800 0 STAT1 MTA1 ZNF740 NCOR1 POLR2A NFXL1 SPI1 GATA1 ENSG00000204620 SLC38A5 MAGIX SSX3 HDAC6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAGIX on UCSC Golden Path with GeneCards custom track

Promoters for MAGIX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246558 1136 1001 HDGF PKNOX1 ATF1 SIN3A GLIS2 ZNF143 ZNF207 ATF7 RUNX3 ZNF202

Genomic Location for MAGIX Gene

Chromosome:
X
Start:
49,162,564 bp from pter
End:
49,168,483 bp from pter
Size:
5,920 bases
Orientation:
Plus strand

Genomic View for MAGIX Gene

Genes around MAGIX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGIX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGIX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGIX Gene

Proteins for MAGIX Gene

  • Protein details for MAGIX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Y5-MAGIX_HUMAN
    Recommended name:
    PDZ domain-containing protein MAGIX
    Protein Accession:
    Q9H6Y5
    Secondary Accessions:
    • A6XND4
    • A8MSX9
    • B7WP26
    • Q14C81

    Protein attributes for MAGIX Gene

    Size:
    334 amino acids
    Molecular mass:
    35217 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MAGIX Gene

    Alternative splice isoforms for MAGIX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGIX Gene

Post-translational modifications for MAGIX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGIX Gene

Domains & Families for MAGIX Gene

Gene Families for MAGIX Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGIX Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGIX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGIX: view

No data available for UniProtKB/Swiss-Prot for MAGIX Gene

Function for MAGIX Gene

genes like me logo Genes that share phenotypes with MAGIX: view

Animal Model Products

CRISPR Products

miRNA for MAGIX Gene

miRTarBase miRNAs that target MAGIX

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGIX Gene

Localization for MAGIX Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGIX gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MAGIX Gene

Pathways & Interactions for MAGIX Gene

SuperPathways for MAGIX Gene

No Data Available

Interacting Proteins for MAGIX Gene

Gene Ontology (GO) - Biological Process for MAGIX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGIX Gene

Drugs & Compounds for MAGIX Gene

No Compound Related Data Available

Transcripts for MAGIX Gene

Unigene Clusters for MAGIX Gene

MAGI family member, X-linked:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGIX Gene

No ASD Table

Relevant External Links for MAGIX Gene

GeneLoc Exon Structure for
MAGIX
ECgene alternative splicing isoforms for
MAGIX

Expression for MAGIX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGIX Gene

mRNA differential expression in normal tissues according to GTEx for MAGIX Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2) and Brain - Cerebellum (x4.2).

Protein differential expression in normal tissues from HIPED for MAGIX Gene

This gene is overexpressed in Adipocyte (49.0), Skin (13.5), and Salivary gland (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAGIX Gene



Protein tissue co-expression partners for MAGIX Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGIX Gene:

MAGIX

SOURCE GeneReport for Unigene cluster for MAGIX Gene:

Hs.193170
genes like me logo Genes that share expression patterns with MAGIX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGIX Gene

Orthologs for MAGIX Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGIX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGIX 33
  • 99.33 (n)
cow
(Bos Taurus)
Mammalia MAGIX 33
  • 79.42 (n)
dog
(Canis familiaris)
Mammalia MAGIX 33
  • 76.56 (n)
mouse
(Mus musculus)
Mammalia Magix 33 16
  • 73.23 (n)
rat
(Rattus norvegicus)
Mammalia Magix 33
  • 71.53 (n)
Species where no ortholog for MAGIX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGIX Gene

ENSEMBL:
Gene Tree for MAGIX (if available)
TreeFam:
Gene Tree for MAGIX (if available)

Paralogs for MAGIX Gene

Paralogs for MAGIX Gene

(4) SIMAP similar genes for MAGIX Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with MAGIX: view

Variants for MAGIX Gene

Sequence variations from dbSNP and Humsavar for MAGIX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000385177 -- 49,161,858(+) GAGAT(C/T)TCTCC upstream-variant-2KB
rs1002335630 -- 49,167,353(+) GCCAG(A/C)GGGAC utr-variant-3-prime
rs1004637469 -- 49,161,225(+) GGCTG(G/T)TCACC upstream-variant-2KB
rs1009085527 -- 49,162,681(+) GCGCC(C/T)GCAGC upstream-variant-2KB, utr-variant-5-prime
rs1009471471 -- 49,165,455(+) GGTTT(A/G)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGIX Gene

Variant ID Type Subtype PubMed ID
dgv4588e59 OTHER inversion 20981092
dgv62n47 OTHER inversion 21111241
dgv63n50 OTHER inversion 21212237
esv1091998 OTHER inversion 17803354
esv2555036 OTHER inversion 19546169
esv32909 CNV gain+loss 17666407
esv994583 OTHER inversion 20482838
nsv205 OTHER inversion 15895083
nsv528292 CNV gain 19592680
nsv7442 OTHER inversion 18451855

Variation tolerance for MAGIX Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGIX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGIX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGIX Gene

Disorders for MAGIX Gene

Relevant External Links for MAGIX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGIX

No disorders were found for MAGIX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGIX Gene

Publications for MAGIX Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for MAGIX Gene

Sources for MAGIX Gene

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