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MAGI3 Gene

protein-coding GIFtS: 53

GC01P113646

membrane associated guanylate kinase, WW and PDZ domain containing 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
KIAA1634 ^³
MAGI-3 ^¹, ², ³
MGC163281 ^²
OTTHUMP00000013454 ^²
OTTHUMP00000013456 ^²
RP4-730K3.1 ^²
dJ730K3.2 ^²

Descriptions
Membrane-associated guanylate kinase inverted 3 ^³
membrane associated guanylate kinase, WW and PDZ domain containing 3 ^²
membrane-associated guanylate kinase-related 3 ^²

External Ids
HGNC: 29647¹
Entrez Gene: 260425²
UniProtKB: Q5TCQ9³
Ensembl: ENSG00000081026⁷

Search outside databases for aliases for MAGI3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9

Function: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular

and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its

interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor

tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells,

involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to

activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4

and VANGL2

Gene Wiki entry for MAGI3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAGI3 gene

Entrez Gene cytogenetic band: 1p12-p11.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p12-p11.2

MAGI3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P113646: (about GC identifiers)

Start:	113,734,998 bp from pter
End:	114,030,068 bp from pter
Size:	295,071 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_019273.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9 (See protein sequence)

Recommended Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

Size: 1506 amino acids; 165608 Da

Subunit: Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with unidentified

tyrosine phosphorylated proteins (By similarity). Interacts with BAI1, LPAR2/EDG4, GRIN2B and

PTEN. In case of infection, interacts with HTLV TAX1 protein, possibly affecting the

transformation ability of TAX1. Does not interact with HTLV TAX2 or TAX3 proteins. In case of

infection, interacts with HPV type 16 and HPV type 18 E6 protein

Subcellular location: Cell membrane; Peripheral membrane protein. Cell junction, tight junction.

Nucleus (By similarity). Note=Concentrates in specific sites at the plasma membrane and in the

nucleus. In epithelial cells, it localizes at tight junctions (By similarity)

Miscellaneous: MAGI3 PDZ domains are used to design peptide ligands that bind and inhibit PDZ

domains

Sequence caution: Sequence=BAB15479.1; Type=Erroneous initiation; Note=Translation N-terminally

extended; Sequence=BAB15479.1; Type=Frameshift; Positions=1373;

Secondary accessions: Q5TCQ8 Q5TCR0 Q9H2V6 Q9H5Y8 Q9HBC4 Q9HCD8

Alternative splicing: 4 isoforms: Q5TCQ9-1 Q5TCQ9-2 Q5TCQ9-3 Q5TCQ9-4

Post-translational modifications:

Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the

proteasome. Degradation is independent of E6AP ubiquitin ligase complex¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001136254.1 NP_690864.2

ENSEMBL proteins:

ENSP00000304604 ENSP00000358630 ENSP00000358624 ENSP00000358628

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MAGI3)
	Human Recombinant Proteins from Abnova (MAGI3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005923	tight junction	IEA	--
GO:0030054	cell junction	IEA	--

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Antibodies for MAGI3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MAGI3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MAGI3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for MAGI3

Assays for MAGI3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q5TCQ9

ProtoNet protein and cluster: Q5TCQ9

UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9

Similarity: Belongs to the MAGUK family

Similarity: Contains 1 guanylate kinase-like domain

Similarity: Contains 6 PDZ (DHR) domains

Similarity: Contains 2 WW domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGI3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAGI3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_152900

Applied Biosystems Silencer® siRNAs for MAGI3

Sigma-Aldrich siRNA for MAGI3

Sigma-Aldrich shRNA for MAGI3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001142782
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001142782
untagged cDNA clones in CMV expression vector (see all 3): NM_001142782

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001142782

UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9

Function: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular

and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its

interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor

tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells,

involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to

activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4

and VANGL2

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for MAGI3 (Your Favorite Gene powered by Ingenuity)

PTEN Signaling

GeneDecks MAGI3 for the pathways selected above

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5/25 Interacting proteins for MAGI3 (Q5TCQ9² ENSP00000304604³) via UniProtKB, MINT, and/or STRING (see all 25 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TJP1	Q07157², ENSP00000281537³	MINT-6800622 STRING (score=.71)
MED28	Q9H204²	MINT-7041908 MINT-7041950
ENSG00000204388	P08107²	MINT-6800622
ENSG00000212866	P08107²	MINT-6800622
ENSG00000215292	P08107²	MINT-6800622

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0044419	interspecies interaction between organisms	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGI3
2 Novoseek chemical compound relationships for MAGI3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
guanylate	86.18	27	10779526 (1), 14770369 (1), 17267446 (1), 18847477 (1) (see all 24)
tyrosine	0.00	6	12615970 (3), 16814777 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGI3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAGI3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_152900

Sigma-Aldrich siRNA for MAGI3

Sigma-Aldrich shRNA for MAGI3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001142782 NM_152900

REFSEQ mRNAs for MAGI3 gene (2 alternative transcripts):

NM_001142782.1 NM_152900.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001142782 NM_152900

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001142782
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001142782
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001142782

Additional cDNA sequence:

AB046854.1 AF213259.1 AK026417.1 AK311589.1 BC130409.1 BC144144.1

8 DOTS entries:

DT.313515 DT.102843014 DT.305513 DT.100754724 DT.91660829 DT.95257128 DT.121414088 DT.121414139

24/99 AceView cDNA sequences (see all 99 ):

BM728137 BF061992 AA007664 AI696507 AI375078 R85666 AA007627 BM728293

AI738585 AI453065 AW512723 AA424967 BX953520 AA447960 AA992863 BQ011994

AI634790 BX115216 AI352360 AB046854 AA812598 AA364373 BM679930 AI167454

highest scoring ESTs for MAGI3:

AA026770 AI692181 AI803958 AA007627 AA007664 AA026771 AA047896 AA054108 AA059189 AA059190

Unigene Cluster for MAGI3:

Membrane associated guanylate kinase, WW and PDZ domain containing 3

Hs.486189 [show with all ESTs]

Unigene Representative Sequence: NM_152900

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000307546 ENST00000369617 ENST00000369611 ENST00000369615

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MAGI3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAGI3

¹ / ² / ³

7 probe-sets matching MAGI3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
52976_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.21	AA026770	1.00	1.00	1.00	1
52977_at²^{, 3}	U95-B	1	1.00	1.00	0.94	1.37	AI692181	1.00	1.00	1.00	1
75488_at²^{, 3}	U95-E	1	1.00	1.00	0.81	0.46	AI803958	1.00	1.00	1.00	1
224307_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF213259	0.80	1.00	0.91	1
226770_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI692181	1.00	1.00	1.00	1
224307_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226770_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MAGI3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.486189
UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9
Tissue specificity: Widely expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAGI3 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAGI3¹	--	membrane associated guanylate kinase, WW and PDZ domain more	92.13(n) 95.68(a)	483214 XM_540332.2 XP_540332.2
cow (Bos taurus)	MAGI3¹	--	membrane associated guanylate kinase, WW and PDZ domain more	93.27(n) 96.22(a)	532952 XM_612177.3 XP_612177.3
rat (Rattus norvegicus)	Magi3¹	--	membrane associated guanylate kinase, WW and PDZ domain more	89.65(n) 93.86(a)	245903 NM_139084.1 NP_620784.1
mouse (Mus musculus)	Magi3^{1, 5}	3 (53.00 cM)⁵	membrane associated guanylate kinase, WW and PDZ domain more^{1, 5}	90.65(n)¹ 95.19(a)¹	99470¹ NM_133853.2¹ NP_598614.1¹ AA407180⁵ AF213258⁵ (see all 17)
chicken (Gallus gallus)	MAGI3¹	--	membrane associated guanylate kinase, WW and PDZ domain more	77.99(n) 85.03(a)	419877 NM_001012697.1 NP_001012715.1

About this table Species with no ortholog for MAGI3

ENSEMBL Gene Tree for MAGI3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAGI3 gene

ENSG00000151276² MAGI2² MAGIX²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1185 NCBI SNPs in MAGI3 are shown (see all 1185 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 275)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6537788^1,2	A,C,F,H	113733222(+)	`GTTTTA/GTAAGG`	1	--	ng5¹ tfbs³		8		EU EA WA	836
	rs13524^1,2	A,C,F,H	114029723(+)	`ATTCAA/GATAGA`	1	--	ut3¹		12		MN EU EA WA NA	1390
	rs10857994^1,2	A,F,H	113735005(+)	`TCTCGC/GGTCTG`	1	--	ut5¹ ese³		4		EU EA WA	416
--	rs1112543^1,2	A,C,F	113733328(+)	`CCACTT/CGAGGG`	1	--	ng5¹ tfbs³		4		EU EA WA	420
	rs4839320^1,2	A,C,F	113734204(+)	`GCGTCT/CCCGCC`	1	--	ng5¹		4		EU EA WA	418
	rs12564503^1,2	C,H	114027018(+)	`ATAATG/ATTCCA`	1	--	ut3¹		3		EU EA	254
	rs4838997^1,2	A,C	114026829(+)	`ATTTTA/GTGTAT`	1	--	ut3¹		0	--	--	--	--
--	rs6683335^1,2	C	113734801(+)	`ACCTCA/CCCGCC`	1	--	ng5¹ tfbs³		0	--	--	--	--
--	rs12568854^1,2	C	113735093(+)	`GGGCCA/GCCCAG`	1	--	ut5¹ ese³		0	--	--	--	--
	rs2359173^1,2	C,F,H,O	113998018(-)	`TTCTGT/CGTTGA`	1	T/T	syn¹ ese³		17		EU EA WA NA	2698

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HapMap Linkage Disequilibrium images for MAGI3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

1 Novoseek disease relationship for MAGI3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0.00	3	10748157 (1), 9434093 (1), 9838122 (1)

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/43 PubMed articles for MAGI3 gene (see all 43 ):

Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. (PubMed id 10748157)^{1, 2, 3, 4} Wu Y....Lasky L.A. (2000)
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{2, 3, 4} Nagase T....Ohara O. (2000)
MAGI-3 regulates LPA-induced activation of Erk and RhoA. (PubMed id 16904289)^{1, 3, 4} Zhang H....Yun C.C. (2007)
Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. (PubMed id 15652357)^{1, 3, 4} Franklin J.L....Coffey R.J. (2005)
Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. (PubMed id 12140759)^{1, 3, 4} Thomas M....Banks L. (2002)
MAGI-1: a widely expressed, alternatively spliced tight junction protein. (PubMed id 11969287)^{1, 3, 4} Laura R.P.... Lasky L.A. (2002)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3. (PubMed id 15003862)^{1, 4} Ohashi M....Fujii M. (2004)
Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins. (PubMed id 12615970)^{1, 3} Adamsky K....Peles E. (2003)
Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. (PubMed id 16316992)^{1, 3} He J....Hall R.A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 260425	HGNC: 29647	AceView: MAGI-3	Ensembl:ENSG00000081026	euGenes: HUgn260425
ECgene: MAGI3	H-InvDB: MAGI3

(According to HUGE)
About This Section

HUGE: KIAA1634

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for MAGI3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MAGI3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAGI3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAGI3		Antibodies for MAGI3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MAGI3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Search Novus for antibodies for MAGI3

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MAGI3 Gene

protein-coding GIFtS: 53

Aliases &
Descriptions
for MAGI3

Summaries
for MAGI3

Genomic Location
for MAGI3

Proteins
for MAGI3

Protein Domains/
Families
for MAGI3

Gene Function
for MAGI3

Pathways & Interactions
for MAGI3

Drugs & Compounds
for MAGI3

Transcripts
for MAGI3

Expression
for MAGI3

Orthologs
for MAGI3

Paralogs
for MAGI3

SNPs/Variants
for MAGI3

Disorders & Mutations
for MAGI3

Medical News
for MAGI3

Publications
for MAGI3

Search for MAGI3

Genome Databases showing MAGI3

Other Databases showing MAGI3

Specialized Databases showing MAGI3

Licensable Technologies
for MAGI3

Services
for MAGI3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAGI3 Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor MAGI3

Summariesfor MAGI3

Genomic Locationfor MAGI3

Proteinsfor MAGI3

Protein Domains/Familiesfor MAGI3

Gene Functionfor MAGI3

Pathways & Interactionsfor MAGI3

Drugs & Compoundsfor MAGI3

Transcriptsfor MAGI3

Expression for MAGI3

Orthologsfor MAGI3

Paralogsfor MAGI3

SNPs/Variantsfor MAGI3

Disorders & Mutationsfor MAGI3

Medical Newsfor MAGI3

Publicationsfor MAGI3

Search for MAGI3

Genome Databases showing MAGI3

Other Databases showing MAGI3

Specialized Databases showing MAGI3

Licensable Technologiesfor MAGI3

Servicesfor MAGI3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAGI3

Summaries
for MAGI3

Genomic Location
for MAGI3

Proteins
for MAGI3

Protein Domains/
Families
for MAGI3

Gene Function
for MAGI3

Pathways & Interactions
for MAGI3

Drugs & Compounds
for MAGI3

Transcripts
for MAGI3

Expression
for MAGI3

Orthologs
for MAGI3

Paralogs
for MAGI3

SNPs/Variants
for MAGI3

Disorders & Mutations
for MAGI3

Medical News
for MAGI3

Publications
for MAGI3

Licensable Technologies
for MAGI3

Services
for MAGI3