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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGI3 Gene

protein-coding   GIFtS: 55
GCID: GC01P113933

Membrane Associated Guanylate Kinase, WW And PDZ Domain...
  5 related diseases
at
MalaCards
 

Aliases
for MAGI3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 31 2     dJ730K3.22
Membrane-Associated Guanylate Kinase Inverted 32 3     Membrane-Associated Guanylate Kinase, WW And PDZ Domain-Containing Protein 32
MAGI-32 3     Membrane-Associated Guanylate Kinase-Related 32
RP4-730K3.12     KIAA16343

External Ids:    HGNC: 296471   Entrez Gene: 2604252   Ensembl: ENSG000000810267   UniProtKB: Q5TCQ93   

Export aliases for MAGI3 gene to outside databases

Previous GC identifers: GC01P113646 GC01P113734 GC01P111791


Summaries
for MAGI3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for MAGI3 Gene: 
MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3) is a protein-coding gene. Diseases associated with MAGI3 include human t-cell leukemia virus type 1, and t-cell leukemia, and among its related super-pathways are Endometrial cancer and Wnt signaling pathway. GO annotations related to this gene include guanylate kinase activity and frizzled binding. An important paralog of this gene is MAGI2.

UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9
Function: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling
processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine
phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma
membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the
ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4
and VANGL2

Gene Wiki entry for MAGI3 Gene


Genomic Views
for MAGI3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGI3 gene promoter:
         TBP   Egr-1   STAT5A   Cdc5   Evi-1   Egr-4   Meis-1b   TFIID   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAGI3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAGI3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGI3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p12-p11.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p12-p11.2

MAGI3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGI3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P113933:  view genomic region     (about GC identifiers)

Start:
 113,933,371 bp from pter      End:
 114,228,545 bp from pter
Size:
 295,175 bases      Orientation:
 plus strand

Proteins
for MAGI3 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9 (See protein sequence)
Recommended Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3  
Size: 1506 amino acids; 165608 Da
Subunit: Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with unidentified tyrosine phosphorylated
proteins (By similarity). Interacts with BAI1, LPAR2/EDG4, GRIN2B and PTEN. In case of infection, interacts with HTLV
TAX1 protein, possibly affecting the transformation ability of TAX1. Does not interact with HTLV TAX2 or TAX3
proteins. In case of infection, interacts with HPV type 16 and HPV type 18 E6 protein
Subcellular location: Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Nucleus (By
similarity). Note=Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it
localizes at tight junctions (By similarity)
Miscellaneous: MAGI3 PDZ domains are used to design peptide ligands that bind and inhibit PDZ domains
Sequence caution: Sequence=BAB15479.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15479.1; Type=Frameshift; Positions=1373;
1 PDB 3D structure from and Proteopedia for MAGI3:
3SOE (3D)    
Secondary accessions: Q5TCQ8 Q5TCR0 Q9H2V6 Q9H5Y8 Q9HBC4 Q9HCD8
Alternative splicing: 4 isoforms:  Q5TCQ9-1   Q5TCQ9-2   Q5TCQ9-3   Q5TCQ9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAGI3: NX_Q5TCQ9

Explore proteomics data for MAGI3 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is
    • independent of E6AP ubiquitin ligase complex
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TCQ9

    • MAGI3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAGI3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001136254.1  NP_690864.2  

    ENSEMBL proteins: 
     ENSP00000358630   ENSP00000304604   ENSP00000358628   ENSP00000358624  

    Human Recombinant Protein Products for MAGI3: 
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    OriGene Protein Over-expression Lysate for MAGI3
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    GenScript Custom Purified and Recombinant Proteins Services for MAGI3
    Novus Biologicals MAGI3 Protein
    Novus Biologicals MAGI3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAGI3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0005911cell-cell junction ----
    GO:0005923tight junction IEA--
    GO:0016020membrane NAS10748157

    MAGI3 for ontologies           About GeneDecksing



    MAGI3 Antibody Products: 
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    Novus Biologicals MAGI3 Antibodies
    Abcam antibodies for MAGI3
    Cloud-Clone Corp. Antibodies for MAGI3 
    ThermoFisher Antibodies for MAGI3
    Search LSBio for Antibodies for MAGI3 

    Assay Products for MAGI3: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MAGI3 
    Cloud-Clone Corp. CLIAs for MAGI3

    Protein Domains /
    Families
    for MAGI3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 5/6 InterPro protein domains (see all 6):
     IPR008144 Guanylate_kin
     IPR008145 Guanylate_kin/L-typ_Ca_channel
     IPR027417 P-loop_NTPase
     IPR001478 PDZ
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q5TCQ9

    ProtoNet protein and cluster: Q5TCQ9

    UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 6 PDZ (DHR) domains
    Similarity: Contains 2 WW domains


    MAGI3 for domains           About GeneDecksing


    Function
    for MAGI3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAGI3_HUMAN, Q5TCQ9
    Function: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling
    processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine
    phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma
    membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the
    ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4
    and VANGL2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004385guanylate kinase activity NAS10748157
    GO:0005109frizzled binding IEA--
    GO:0005515protein binding IPI16316992
    GO:0005524ATP binding IEA--
         
    MAGI3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MAGI3:
     Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAGI3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAGI3

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAGI3
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate MAGI3 (see all 24):
    hsa-miR-142-5p hsa-miR-30c hsa-miR-1271 hsa-miR-30d hsa-miR-340 hsa-miR-410 hsa-miR-548m hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: MAGI3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAGI3
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    Sirion Biotech Custom design and validation of potent shRNA sequences against MAGI3

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of MAGI3
                         Customized adenovirus for potent knockdown of MAGI3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAGI3 (see all 12)
    OriGene ORF clones in mouse, rat for MAGI3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAGI3 (NM_001142782)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGI3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGI3

    Cell Line
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    Search LifeMap BioReagents cell lines for MAGI3
    Sirion Biotech Customized stable knockdown cell line services for MAGI3
                         Customized inducible knockdown cell line services for MAGI3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGI3


    Pathways & Interactions
    for MAGI3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAGI3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Endometrial cancer
    		Signal transduction PTEN pathway0.45
    2Wnt signaling pathway
    		Wnt Signaling Pathway NetPath0.37
    3Tight junction
    		Tight junction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for MAGI3
        Signal transduction PTEN pathway


    1 GeneGo (Thomson Reuters) Pathway for MAGI3
        Signal transduction PTEN pathway

    1 BioSystems Pathway for MAGI3
        Wnt Signaling Pathway NetPath


    1         Kegg Pathway  (Kegg details for MAGI3):
        Tight junction


    MAGI3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGI3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for MAGI3 (Q5TCQ91, 2, 3 ENSP000003046044) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRB2P075502, 3, ENSP000003053724MINT-7716320 MINT-7716382 MINT-7716556 MINT-7716470 MINT-7716630 MINT-7716422 MINT-7716450 MINT-7716502 MINT-7716335 I2D: score=2 STRING: ENSP00000305372
    PTENP604842, 3, ENSP000003610214MINT-1796736 MINT-1796842 MINT-72925 MINT-1796814 MINT-72923 MINT-72927 I2D: score=4 STRING: ENSP00000361021
    BAI1O145142, 3, ENSP000003130464MINT-72930 MINT-1796764 I2D: score=4 STRING: ENSP00000313046
    GRIN2BQ132242, 3, ENSP000002795934MINT-1796789 MINT-72931 I2D: score=3 STRING: ENSP00000279593
    MED28Q9H2042, 3, ENSP000002373804MINT-7041950 MINT-7041908 I2D: score=1 STRING: ENSP00000237380
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process NAS10748157
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0035556intracellular signal transduction NAS10748157
    GO:0043507positive regulation of JUN kinase activity IEA--

    MAGI3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAGI3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAGI3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAGI3

    4 Novoseek inferred chemical compound relationships for MAGI3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 86.6 29 10779526 (1), 14770369 (1), 17267446 (1), 18847477 (1) (see all 26)
    valine 30 1 16316992 (1)
    glutamate 9.07 2 18367167 (1), 10595517 (1)
    tyrosine 0 6 12615970 (3), 16814777 (1)

    Search CenterWatch for drugs/clinical trials and news about MAGI3

    Transcripts
    for MAGI3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAGI3 gene (3 alternative transcripts): 
    NM_020965.2  NM_001142782.1  NM_152900.2  

    Unigene Cluster for MAGI3:

    Membrane associated guanylate kinase, WW and PDZ domain containing 3
    Hs.486189  [show with all ESTs]
    Unigene Representative Sequence: NM_152900
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369617(uc001edh.3) ENST00000307546(uc001edk.3 uc009wgo.3)
    ENST00000369615(uc001edi.4 uc010owm.2 uc001edj.3) ENST00000369611
    ENST00000486456 ENST00000477955
    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate MAGI3 (see all 24):
    hsa-miR-142-5p hsa-miR-30c hsa-miR-1271 hsa-miR-30d hsa-miR-340 hsa-miR-410 hsa-miR-548m hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: MAGI3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MAGI3
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGI3
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGI3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGI3

    Additional mRNA sequence: 

    AB046854.1 AF213259.1 AK026417.1 AK311589.1 BC130409.1 BC144144.1 

    8 DOTS entries:

    DT.313515  DT.102843014  DT.305513  DT.100754724  DT.91660829  DT.121414088  DT.121414139  DT.95257128 

    24/99 AceView cDNA sequences (see all 99):

    BX953520 AB046854 BM728293 AA007627 BX115216 BQ011994 AA447960 AI375078 
    BM728137 AI453065 AI634790 AI738585 AW512723 AA007664 AA424967 BF061992 
    AI696507 AA812598 AA992863 AI352360 R85666 AI521837 BX507970 NM_020965 

    GeneLoc Exon Structure


    Expression
    for MAGI3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGI3 expression in normal human tissues (normalized intensities)      MAGI3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAGI3 Expression
    About this image


    MAGI3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Testis (Reproductive System)
             sperm

    See MAGI3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAGI3

    SOURCE GeneReport for Unigene cluster: Hs.486189

    UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for MAGI3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGI3

    Orthologs
    for MAGI3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MAGI3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Magi31 , 5 membrane associated guanylate kinase, WW and PDZ domain more1, 5 87.29(n)1
    87.08(a)1    		   3 (45.52 cM)5
    994701  NM_001159354.11  NP_001152826.11 
     1040132595 
    chicken
    (Gallus gallus)    		 Aves MAGI31 membrane associated guanylate kinase, WW and PDZ domain more 77.88(n)
    85.08(a)    		   419877  NM_001012697.1  NP_001012715.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAGI36
    		 Uncharacterized protein
    		 71(a)
    		 1 ↔ 1
    		 4(139398135-139609548)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi36a102 Transcribed sequence with weak similarity to protein more 77.36(n)    57072019 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Magi6
    		 Magi
    		 23(a)
    		 possible ortholog
    		 2R(17016968-17030067)
    worm
    (Caenorhabditis elegans)    		 Secernentea magi-16
    		 Protein MAGI-1, isoform a
    		 31(a)
    		 possible ortholog
    		 IV(11715090-11729281)


    ENSEMBL Gene Tree for MAGI3 (if available)
    TreeFam Gene Tree for MAGI3 (if available)

    Paralogs
    for MAGI3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGI3 gene
    MAGI22  SAV12  MAGIX2  MAGI12  
    3 SIMAP similar genes for MAGI3 using alignment to 1 protein entry:     MAGI3_HUMAN:
    MAGI2    SYNJ2BP    MAGI1

    MAGI3 for paralogs           About GeneDecksing



    Genomic Variants
    for MAGI3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5097 SNPs in MAGI3 are shown (see all 5097)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1873233541,2
    		--113931582(+) CCTGCC/TCACAT 2 -- us2k10--------
    rs793245051,2
    		F--113931648(+) ACGAAA/GTCACT 2 -- us2k11Minor allele frequency- G:0.09WA 118
    rs65377881,2
    		C,F,A,H--113931699(+) GTTTTA/GTAAGG 2 -- us2k1 tfbs320Minor allele frequency- G:0.05NS EA NA CSA WA 2385
    rs11125431,2
    		C,F,A,H--113931805(+) CCACTT/CGAGGG 2 -- us2k1 tfbs320Minor allele frequency- C:0.29NS EA NA 2418
    rs1481845971,2
    		--113931915(+) AAGAGC/TGTAAG 2 -- us2k10--------
    rs1922362341,2
    		--113932009(+) TTCGTC/TCTCCC 2 -- us2k10--------
    rs1163565311,2
    		F--113932251(+) ACAATA/GTCTAA 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1468660491,2
    		--113932277(+) GTCAT-/CAGCAGCA 2 -- us2k10--------
    rs726879131,2
    		C--113932279(+) CATCAG/TCAGCA 2 -- us2k10--------
    rs1411423281,2
    		--113932466(+) CAACCA/GGACTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAGI3 (113933371 - 114183371 bp, first 250kb of MAGI3)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for MAGI3 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716429CNV Deletion23290073
    esv2664101CNV Deletion23128226
    esv2676508CNV Deletion23128226
    nsv435905CNV Deletion17901297
    esv2716440CNV Deletion23290073
    esv2670349CNV Deletion23128226
    esv1062910CNV Insertion17803354
    esv1673662CNV Insertion17803354
    esv1257635CNV Insertion17803354
    nsv437013CNV Loss16327808

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    Disorders / Diseases
    for MAGI3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAGI3 for disorders           About GeneDecksing

    5 diseases for MAGI3:    About MalaCards
    human t-cell leukemia virus type 1    t-cell leukemia    b-cell lymphomas    colon cancer
    leukemia

    1 Novoseek inferred disease relationship for MAGI3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 10748157 (1), 9434093 (1), 9838122 (1)

    Genetic Association Database (GAD): MAGI3
    Human Genome Epidemiology (HuGE) Navigator: MAGI3 (3 documents)

    Export disorders for MAGI3 gene to outside databases

    Publications
    for MAGI3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGI3 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with MAGI3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. (PubMed id 10748157)1, 2, 3, 9 Wu Y.... Lasky L.A. (2000)
    2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. MAGI-3 regulates LPA-induced activation of Erk and RhoA. (PubMed id 16904289)1, 2, 9 Zhang H....Yun C.C. (2007)
    4. Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. (PubMed id 15652357)1, 2, 9 Franklin J.L.... Coffey R.J. (2005)
    5. Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. (PubMed id 12140759)1, 2, 9 Thomas M....Banks L. (2002)
    6. MAGI-1: a widely expressed, alternatively spliced tight junction protein. (PubMed id 11969287)1, 2, 9 Laura R.P.... Lasky L.A. (2002)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3. (PubMed id 15003862)2, 9 Ohashi M....Fujii M. (2004)
    10. Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins. (PubMed id 12615970)1, 9 Adamsky K....Peles E. (2003)

    External Searches for MAGI3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAGI3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 260425 HGNC: 29647 AceView: MAGI-3 Ensembl:ENSG00000081026 euGenes: HUgn260425
    ECgene: MAGI3 Kegg: 260425 H-InvDB: MAGI3

    Other Databases showing MAGI3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1634

    Specialized Databases showing MAGI3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAGI3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAGI3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAGI3 gene:
    Search GeneIP for patents involving MAGI3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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