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Aliases for MAGI3 Gene

Aliases for MAGI3 Gene

  • Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 3 2 3 5
  • Membrane-Associated Guanylate Kinase Inverted 3 3 4
  • MAGI-3 3 4
  • Membrane-Associated Guanylate Kinase-Related 3 3
  • DJ730K3.2 3
  • KIAA1634 4

External Ids for MAGI3 Gene

Previous GeneCards Identifiers for MAGI3 Gene

  • GC01P113646
  • GC01P113734
  • GC01P113933
  • GC01P111791

Summaries for MAGI3 Gene

GeneCards Summary for MAGI3 Gene

MAGI3 (Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 3) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Tight junction. GO annotations related to this gene include frizzled binding and guanylate kinase activity. An important paralog of this gene is MAGI2.

UniProtKB/Swiss-Prot for MAGI3 Gene

  • Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.

Gene Wiki entry for MAGI3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGI3 Gene

Genomics for MAGI3 Gene

Regulatory Elements for MAGI3 Gene

Enhancers for MAGI3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAGI3 on UCSC Golden Path with GeneCards custom track

Promoters for MAGI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAGI3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAGI3 Gene

Chromosome:
1
Start:
113,390,474 bp from pter
End:
113,685,923 bp from pter
Size:
295,450 bases
Orientation:
Plus strand

Genomic View for MAGI3 Gene

Genes around MAGI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGI3 Gene

Proteins for MAGI3 Gene

  • Protein details for MAGI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCQ9-MAGI3_HUMAN
    Recommended name:
    Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
    Protein Accession:
    Q5TCQ9
    Secondary Accessions:
    • Q5TCQ8
    • Q5TCR0
    • Q9H2V6
    • Q9H5Y8
    • Q9HBC4
    • Q9HCD8

    Protein attributes for MAGI3 Gene

    Size:
    1506 amino acids
    Molecular mass:
    165608 Da
    Quaternary structure:
    • Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with unidentified tyrosine phosphorylated proteins (By similarity). Interacts with BAI1, LPAR2/EDG4, GRIN2B and PTEN. In case of infection, interacts with HTLV TAX1 protein, possibly affecting the transformation ability of TAX1. Does not interact with HTLV TAX2 or TAX3 proteins. In case of infection, interacts with HPV type 16 and HPV type 18 E6 protein. Interacts with DLL1 (By similarity).
    Miscellaneous:
    • MAGI3 PDZ domains are used to design peptide ligands that bind and inhibit PDZ domains.
    SequenceCaution:
    • Sequence=BAB15479.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15479.1; Type=Frameshift; Positions=1373; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAGI3 Gene

    Alternative splice isoforms for MAGI3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGI3 Gene

Proteomics data for MAGI3 Gene at MOPED

Post-translational modifications for MAGI3 Gene

  • Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGI3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAGI3 (MAGI3)

No data available for DME Specific Peptides for MAGI3 Gene

Domains & Families for MAGI3 Gene

Suggested Antigen Peptide Sequences for MAGI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TCQ9

UniProtKB/Swiss-Prot:

MAGI3_HUMAN :
  • Contains 1 guanylate kinase-like domain.
  • Belongs to the MAGUK family.
Domain:
  • Contains 1 guanylate kinase-like domain.
  • Contains 6 PDZ (DHR) domains.
  • Contains 2 WW domains.
Family:
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with MAGI3: view

Function for MAGI3 Gene

Molecular function for MAGI3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.

Gene Ontology (GO) - Molecular Function for MAGI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 16316992
genes like me logo Genes that share ontologies with MAGI3: view
genes like me logo Genes that share phenotypes with MAGI3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGI3 Gene

Localization for MAGI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGI3 Gene

Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Nucleus. Note=Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGI3 Gene COMPARTMENTS Subcellular localization image for MAGI3 gene
Compartment Confidence
nucleus 4
plasma membrane 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAGI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IEA --
genes like me logo Genes that share ontologies with MAGI3: view

Pathways & Interactions for MAGI3 Gene

genes like me logo Genes that share pathways with MAGI3: view

Pathways by source for MAGI3 Gene

1 Cell Signaling Technology pathway for MAGI3 Gene
1 BioSystems pathway for MAGI3 Gene
2 KEGG pathways for MAGI3 Gene
1 GeneGo (Thomson Reuters) pathway for MAGI3 Gene

Gene Ontology (GO) - Biological Process for MAGI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process NAS 10748157
GO:0016032 viral process IEA --
GO:0046328 regulation of JNK cascade IEA --
GO:0046710 GDP metabolic process NAS 10748157
genes like me logo Genes that share ontologies with MAGI3: view

No data available for SIGNOR curated interactions for MAGI3 Gene

Drugs & Compounds for MAGI3 Gene

(2) Drugs for MAGI3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MAGI3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAGI3: view

Transcripts for MAGI3 Gene

Unigene Clusters for MAGI3 Gene

Membrane associated guanylate kinase, WW and PDZ domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGI3 Gene

No ASD Table

Relevant External Links for MAGI3 Gene

GeneLoc Exon Structure for
MAGI3
ECgene alternative splicing isoforms for
MAGI3

Expression for MAGI3 Gene

mRNA expression in normal human tissues for MAGI3 Gene

Protein differential expression in normal tissues from HIPED for MAGI3 Gene

This gene is overexpressed in Brain (31.5), NK cells (17.8), and Heart (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGI3 Gene



SOURCE GeneReport for Unigene cluster for MAGI3 Gene Hs.486189

mRNA Expression by UniProt/SwissProt for MAGI3 Gene

Q5TCQ9-MAGI3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with MAGI3: view

Protein tissue co-expression partners for MAGI3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAGI3 Gene

Orthologs for MAGI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAGI3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAGI3 35
  • 90.17 (n)
  • 90.01 (a)
MAGI3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAGI3 35
  • 88.38 (n)
  • 87.64 (a)
MAGI3 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Magi3 35
  • 86.89 (n)
  • 86.96 (a)
mouse
(Mus musculus)
Mammalia Magi3 16
Magi3 36
  • 87 (a)
OneToOne
Magi3 35
  • 87.29 (n)
  • 87.08 (a)
oppossum
(Monodelphis domestica)
Mammalia MAGI3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAGI3 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAGI3 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAGI3 36
  • 84 (a)
OneToOne
MAGI3 35
  • 77.88 (n)
  • 85.08 (a)
lizard
(Anolis carolinensis)
Reptilia MAGI3 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia magi3 35
  • 72.38 (n)
  • 81.29 (a)
zebrafish
(Danio rerio)
Actinopterygii magi3 35
  • 62.22 (n)
  • 64.56 (a)
wufi36a10 35
magi3 36
  • 59 (a)
OneToMany
MAGI3 (1 of 3) 36
  • 63 (a)
OneToMany
magixb 36
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Magi 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea magi-1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for MAGI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAGI3 Gene

ENSEMBL:
Gene Tree for MAGI3 (if available)
TreeFam:
Gene Tree for MAGI3 (if available)

Paralogs for MAGI3 Gene

Paralogs for MAGI3 Gene

(3) SIMAP similar genes for MAGI3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAGI3: view

Variants for MAGI3 Gene

Sequence variations from dbSNP and Humsavar for MAGI3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs13524 -- 113,685,578(+) ATTCA(A/G)ATAGA utr-variant-3-prime
rs1106209 -- 113,508,833(-) TTTTT(A/T)AAAAA intron-variant
rs1112085 -- 113,398,543(+) AACAC(A/G)TAATT intron-variant
rs1112543 -- 113,389,183(+) CCACT(C/T)GAGGG upstream-variant-2KB
rs1113523 -- 113,586,852(+) CTTTT(A/G)GCGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGI3 Gene

Variant ID Type Subtype PubMed ID
esv23869 CNV Loss 19812545
esv2670349 CNV Deletion 23128226
esv2716429 CNV Deletion 23290073
esv1257635 CNV Insertion 17803354
esv1062910 CNV Insertion 17803354
esv1673662 CNV Insertion 17803354
nsv508548 CNV Loss 20534489
nsv435905 CNV Deletion 17901297
esv2716440 CNV Deletion 23290073
esv2676508 CNV Deletion 23128226
esv5987 CNV Loss 19470904
nsv824254 CNV Gain 20364138
nsv437013 CNV Loss 16327808
esv2664101 CNV Deletion 23128226
nsv872161 CNV Loss 21882294

Variation tolerance for MAGI3 Gene

Residual Variation Intolerance Score: 1.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGI3 Gene

HapMap Linkage Disequilibrium report
MAGI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGI3 Gene

Disorders for MAGI3 Gene

Relevant External Links for MAGI3

Genetic Association Database (GAD)
MAGI3
Human Genome Epidemiology (HuGE) Navigator
MAGI3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGI3

No disorders were found for MAGI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGI3 Gene

Publications for MAGI3 Gene

  1. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. (PMID: 10748157) Wu Y. … Lasky L.A. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Beta-2 adrenergic receptor mediated ERK activation is regulated by interaction with MAGI-3. (PMID: 20353789) Yang X. … He J. (FEBS Lett. 2010) 3 23
  3. MAGI-3 regulates LPA-induced activation of Erk and RhoA. (PMID: 16904289) Zhang H. … Yun C.C. (Cell. Signal. 2007) 3 23
  4. Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. (PMID: 16316992) He J. … Hall R.A. (J. Biol. Chem. 2006) 3 23
  5. Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. (PMID: 15652357) Franklin J.L. … Coffey R.J. (Exp. Cell Res. 2005) 3 23

Products for MAGI3 Gene

Sources for MAGI3 Gene

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