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Aliases for MAGI3 Gene

Aliases for MAGI3 Gene

  • Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 3 2 3 5
  • Membrane-Associated Guanylate Kinase Inverted 3 3 4
  • MAGI-3 3 4
  • Membrane-Associated Guanylate Kinase, WW And PDZ Domain-Containing Protein 3 3
  • Membrane-Associated Guanylate Kinase-Related 3 3
  • DJ730K3.2 3
  • KIAA1634 4

External Ids for MAGI3 Gene

Previous GeneCards Identifiers for MAGI3 Gene

  • GC01P113646
  • GC01P113734
  • GC01P113933
  • GC01P111791

Summaries for MAGI3 Gene

GeneCards Summary for MAGI3 Gene

MAGI3 (Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 3) is a Protein Coding gene. Among its related pathways are Tight junction and Ras signaling pathway. GO annotations related to this gene include frizzled binding and guanylate kinase activity. An important paralog of this gene is MAGI2.

UniProtKB/Swiss-Prot for MAGI3 Gene

  • Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.

Gene Wiki entry for MAGI3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGI3 Gene

Genomics for MAGI3 Gene

Regulatory Elements for MAGI3 Gene

Enhancers for MAGI3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F113388 1.4 Ensembl ENCODE 12.2 +1.4 1443 7.3 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 LOC100421402 MAGI3 LRIG2 AP4B1 GC01M113381
GH01F113216 1.4 Ensembl ENCODE 10.2 -172.2 -172188 4.0 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 RSBN1 LOC100421402 LRIG2 MAGI3 LOC100996251 GC01P113218 LOC643441
GH01F113779 1.5 FANTOM5 Ensembl ENCODE 5.6 +392.6 392628 7.0 HDGF HDAC1 PKNOX1 ATF1 ARNT FEZF1 ELK1 ZNF366 ETV6 CREM RSBN1 PHTF1 ENSG00000231128 AP4B1 LOC100421402 MAGI3 PTPN22 HIPK1 PIR59903
GH01F113809 1.2 ENCODE 5.6 +421.1 421078 4.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 OLFML3 LRIG2 TRIM33 PHTF1 SIKE1 LOC100421402 AP4B1-AS1 AP4B1 PTPN22 MAGI3
GH01F113869 1 ENCODE 5.2 +482.7 482705 7.6 HDGF PKNOX1 ATF1 YBX1 YY1 ZNF121 GATA2 CBX5 ZNF143 ZNF207 RSBN1 AP4B1 PHTF1 DCLRE1B ENSG00000231128 HIPK1 HIPK1-AS1 LOC100421402 PTPN22 TRIM33
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAGI3 on UCSC Golden Path with GeneCards custom track

Promoters for MAGI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000670802 626 4600 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MAGI3 Gene

Chromosome:
1
Start:
113,390,474 bp from pter
End:
113,685,923 bp from pter
Size:
295,450 bases
Orientation:
Plus strand

Genomic View for MAGI3 Gene

Genes around MAGI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGI3 Gene

Proteins for MAGI3 Gene

  • Protein details for MAGI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TCQ9-MAGI3_HUMAN
    Recommended name:
    Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
    Protein Accession:
    Q5TCQ9
    Secondary Accessions:
    • Q5TCQ8
    • Q5TCR0
    • Q9H2V6
    • Q9H5Y8
    • Q9HBC4
    • Q9HCD8

    Protein attributes for MAGI3 Gene

    Size:
    1506 amino acids
    Molecular mass:
    165608 Da
    Quaternary structure:
    • Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with unidentified tyrosine phosphorylated proteins (By similarity). Interacts with BAI1, LPAR2/EDG4, GRIN2B and PTEN. In case of infection, interacts with HTLV TAX1 protein, possibly affecting the transformation ability of TAX1. Does not interact with HTLV TAX2 or TAX3 proteins. In case of infection, interacts with HPV type 16 and HPV type 18 E6 protein. Interacts with DLL1 (By similarity).
    Miscellaneous:
    • MAGI3 PDZ domains are used to design peptide ligands that bind and inhibit PDZ domains.
    SequenceCaution:
    • Sequence=BAB15479.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15479.1; Type=Frameshift; Positions=1373; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAGI3 Gene

    Alternative splice isoforms for MAGI3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGI3 Gene

Post-translational modifications for MAGI3 Gene

  • Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAGI3 (MAGI3)
  • Santa Cruz Biotechnology (SCBT) Antibodies for MAGI3

No data available for DME Specific Peptides for MAGI3 Gene

Domains & Families for MAGI3 Gene

Suggested Antigen Peptide Sequences for MAGI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TCQ9

UniProtKB/Swiss-Prot:

MAGI3_HUMAN :
  • Contains 1 guanylate kinase-like domain.
  • Belongs to the MAGUK family.
Domain:
  • Contains 1 guanylate kinase-like domain.
  • Contains 6 PDZ (DHR) domains.
  • Contains 2 WW domains.
Family:
  • Belongs to the MAGUK family.
genes like me logo Genes that share domains with MAGI3: view

Function for MAGI3 Gene

Molecular function for MAGI3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.

Gene Ontology (GO) - Molecular Function for MAGI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004385 guanylate kinase activity NAS 10748157
GO:0005515 protein binding IPI 16316992
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0032947 protein complex scaffold IEA --
genes like me logo Genes that share ontologies with MAGI3: view
genes like me logo Genes that share phenotypes with MAGI3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGI3 Gene

Localization for MAGI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGI3 Gene

Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Nucleus. Note=Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGI3 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAGI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
GO:0005911 cell-cell junction IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016020 membrane NAS 10748157
genes like me logo Genes that share ontologies with MAGI3: view

Pathways & Interactions for MAGI3 Gene

genes like me logo Genes that share pathways with MAGI3: view

Pathways by source for MAGI3 Gene

1 Cell Signaling Technology pathway for MAGI3 Gene
2 KEGG pathways for MAGI3 Gene
1 GeneGo (Thomson Reuters) pathway for MAGI3 Gene

Gene Ontology (GO) - Biological Process for MAGI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process NAS 10748157
GO:0007165 signal transduction IEA --
GO:0016032 viral process IEA --
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction NAS 10748157
genes like me logo Genes that share ontologies with MAGI3: view

No data available for SIGNOR curated interactions for MAGI3 Gene

Drugs & Compounds for MAGI3 Gene

(2) Drugs for MAGI3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MAGI3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAGI3: view

Transcripts for MAGI3 Gene

Unigene Clusters for MAGI3 Gene

Membrane associated guanylate kinase, WW and PDZ domain containing 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGI3 Gene

No ASD Table

Relevant External Links for MAGI3 Gene

GeneLoc Exon Structure for
MAGI3
ECgene alternative splicing isoforms for
MAGI3

Expression for MAGI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAGI3 Gene

Protein differential expression in normal tissues from HIPED for MAGI3 Gene

This gene is overexpressed in Brain (31.5), NK cells (17.8), and Heart (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAGI3 Gene



Protein tissue co-expression partners for MAGI3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGI3 Gene:

MAGI3

SOURCE GeneReport for Unigene cluster for MAGI3 Gene:

Hs.486189

mRNA Expression by UniProt/SwissProt for MAGI3 Gene:

Q5TCQ9-MAGI3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with MAGI3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAGI3 Gene

Orthologs for MAGI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAGI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGI3 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAGI3 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAGI3 34 35
  • 90.17 (n)
dog
(Canis familiaris)
Mammalia MAGI3 34 35
  • 88.38 (n)
mouse
(Mus musculus)
Mammalia Magi3 34 16 35
  • 87.29 (n)
rat
(Rattus norvegicus)
Mammalia Magi3 34
  • 86.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAGI3 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAGI3 34 35
  • 77.88 (n)
lizard
(Anolis carolinensis)
Reptilia MAGI3 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia magi3 34
  • 72.38 (n)
zebrafish
(Danio rerio)
Actinopterygii MAGI3 (1 of 3) 35
  • 63 (a)
OneToMany
magi3 34 35
  • 62.22 (n)
magixb 35
  • 30 (a)
OneToMany
wufi36a10 34
fruit fly
(Drosophila melanogaster)
Insecta Magi 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea magi-1 35
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToMany
Species where no ortholog for MAGI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAGI3 Gene

ENSEMBL:
Gene Tree for MAGI3 (if available)
TreeFam:
Gene Tree for MAGI3 (if available)

Paralogs for MAGI3 Gene

Paralogs for MAGI3 Gene

(3) SIMAP similar genes for MAGI3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAGI3: view

Variants for MAGI3 Gene

Sequence variations from dbSNP and Humsavar for MAGI3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157946 -- 113,471,483(+) gggaa(A/G)ttcat intron-variant
rs10458457 -- 113,424,200(+) CCGCc(G/T)cctgc intron-variant
rs10458458 -- 113,424,319(+) tttgt(C/G)tatct intron-variant
rs10458459 -- 113,424,783(+) attgg(C/T)tcatg intron-variant
rs10489936 -- 113,612,787(+) TAAAT(C/G)AACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGI3 Gene

Variant ID Type Subtype PubMed ID
nsv956241 CNV deletion 24416366
nsv946152 CNV duplication 23825009
nsv946151 CNV duplication 23825009
nsv824254 CNV gain 20364138
nsv508548 CNV deletion 20534489
nsv476753 CNV novel sequence insertion 20440878
nsv437013 CNV loss 16327808
nsv435905 CNV deletion 17901297
nsv1133889 CNV deletion 24896259
nsv1125468 CNV tandem duplication 24896259
nsv1012324 CNV loss 25217958
esv5987 CNV loss 19470904
esv3587242 CNV loss 21293372
esv3587240 CNV loss 21293372
esv3587239 CNV loss 21293372
esv3587238 CNV loss 21293372
esv3587236 CNV loss 21293372
esv3584359 CNV gain 25503493
esv3578117 CNV loss 25503493
esv3539756 CNV deletion 23714750
esv2716440 CNV deletion 23290073
esv2716429 CNV deletion 23290073
esv2676508 CNV deletion 23128226
esv2670349 CNV deletion 23128226
esv2664101 CNV deletion 23128226
esv23869 CNV loss 19812545
esv1673662 CNV insertion 17803354
esv1257635 CNV insertion 17803354
esv1062910 CNV insertion 17803354
dgv291n100 CNV gain 25217958
dgv145n106 CNV deletion 24896259

Variation tolerance for MAGI3 Gene

Residual Variation Intolerance Score: 1.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGI3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGI3 Gene

Disorders for MAGI3 Gene

Relevant External Links for MAGI3

Genetic Association Database (GAD)
MAGI3
Human Genome Epidemiology (HuGE) Navigator
MAGI3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGI3

No disorders were found for MAGI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGI3 Gene

Publications for MAGI3 Gene

  1. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. (PMID: 10748157) Wu Y. … Lasky L.A. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. MAGI-3 regulates LPA-induced activation of Erk and RhoA. (PMID: 16904289) Zhang H. … Yun C.C. (Cell. Signal. 2007) 3 4 22 64
  3. Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. (PMID: 15652357) Franklin J.L. … Coffey R.J. (Exp. Cell Res. 2005) 3 4 22 64
  4. MAGI-1: a widely expressed, alternatively spliced tight junction protein. (PMID: 11969287) Laura R.P. … Lasky L.A. (Exp. Cell Res. 2002) 3 4 22 64
  5. Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. (PMID: 12140759) Thomas M. … Banks L. (Oncogene 2002) 3 4 22 64

Products for MAGI3 Gene

Sources for MAGI3 Gene

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