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MAGI3 Gene

protein-coding GIFtS: 53
GCID: GC01P113933

Membrane Associated Guanylate Kinase, WW And PDZ Domain...

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 3¹ ²		Membrane-Associated Guanylate Kinase, WW And PDZ Domain-Containing Protein 3²
Membrane-Associated Guanylate Kinase Inverted 3² ³		Membrane-Associated Guanylate Kinase-Related 3²
MAGI-3² ³		KIAA1634³
dJ730K3.2²

External Ids:	HGNC: 29647¹	Entrez Gene: 260425²	Ensembl: ENSG00000081026⁷	UniProtKB: Q5TCQ9³

Export aliases for MAGI3 gene to outside databases

Previous GC identifers: GC01P113646 GC01P113734 GC01P111791

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAGI3 Gene:

MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3) is a protein-coding gene. Diseases associated with MAGI3 include human t-cell leukemia virus type 1, and t-cell leukemia. GO annotations related to this gene include guanylate kinase activity and frizzled binding. An important paralog of this gene is MAGI2.

UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9

Function: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling

processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine

phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma

membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates

the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction

with FZD4 and VANGL2

Gene Wiki entry for MAGI3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000001.11 NT_032977.10 NC_018912.2

Regulatory elements:

Regulatory transcription factor binding sites in the MAGI3 gene promoter:
TBP Egr-1 STAT5A Cdc5 Evi-1 Egr-4 Meis-1b TFIID Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAGI3 promoter sequence

Search Chromatin IP Primers for MAGI3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGI3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p12-p11.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p12-p11.2

MAGI3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGI3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P113933: view genomic region (about GC identifiers)

Start:	113,933,371 bp from pter	End:	114,228,545 bp from pter
Size:	295,175 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9 (See protein sequence)

Recommended Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

Size: 1506 amino acids; 165608 Da

Subunit: Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with unidentified tyrosine

phosphorylated proteins (By similarity). Interacts with BAI1, LPAR2/EDG4, GRIN2B and PTEN. In case of infection,

interacts with HTLV TAX1 protein, possibly affecting the transformation ability of TAX1. Does not interact with

HTLV TAX2 or TAX3 proteins. In case of infection, interacts with HPV type 16 and HPV type 18 E6 protein

Miscellaneous: MAGI3 PDZ domains are used to design peptide ligands that bind and inhibit PDZ domains

Sequence caution: Sequence=BAB15479.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAB15479.1; Type=Frameshift; Positions=1373;

1 PDB 3D structure from and Proteopedia for MAGI3:

3SOE (3D)

Secondary accessions: Q5TCQ8 Q5TCR0 Q9H2V6 Q9H5Y8 Q9HBC4 Q9HCD8

Alternative splicing: 4 isoforms: Q5TCQ9-1 Q5TCQ9-2 Q5TCQ9-3 Q5TCQ9-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAGI3: NX_Q5TCQ9

Explore proteomics data for MAGI3 at MOPED

Post-translational modifications:

Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation

is independent of E6AP ubiquitin ligase complex¹

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See MAGI3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001136254.1 NP_690864.2

ENSEMBL proteins:

ENSP00000358630 ENSP00000304604 ENSP00000358628 ENSP00000358624

MAGI3 Human Recombinant Protein Products:

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	Novus Biologicals MAGI3 Protein Novus Biologicals MAGI3 Lysate
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	Cloud-Clone Corp. Proteins for MAGI3

MAGI3 Antibody Products:

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	Novus Biologicals MAGI3 Antibodies
	Abcam antibodies for MAGI3
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	ThermoFisher Antibodies for MAGI3
	Search LSBio for Antibodies for MAGI3

MAGI3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for MAGI3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for MAGI3 Cloud-Clone Corp. CLIAs for MAGI3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 6):

IPR008144 Guanylate_kin-like

IPR008145 GK/Ca_channel_bsu

IPR027417 P-loop_NTPase

IPR001478 PDZ

IPR001202 WW_dom

Graphical View of Domain Structure for InterPro Entry Q5TCQ9

ProtoNet protein and cluster: Q5TCQ9

UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9

Similarity: Belongs to the MAGUK family

Similarity: Contains 1 guanylate kinase-like domain

Similarity: Contains 6 PDZ (DHR) domains

Similarity: Contains 2 WW domains

MAGI3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: MAGI3_HUMAN, Q5TCQ9

Function: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling

processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine

phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma

membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates

the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction

with FZD4 and VANGL2

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004385	guanylate kinase activity	NAS	10748157
GO:0005109	frizzled binding	IEA	--
GO:0005515	protein binding	IPI	16316992
GO:0005524	ATP binding	IEA	--

MAGI3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MAGI3:

Decreased Salmonella enterica

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAGI3

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genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAGI3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAGI3

miRNA Products:		Block miRNA regulation of human, mouse, rat MAGI3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MAGI3 (see all 24):
		hsa-miR-142-5p hsa-miR-30c hsa-miR-1271 hsa-miR-30d hsa-miR-340 hsa-miR-410 hsa-miR-548m hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: MAGI3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MAGI3
		Predesigned siRNA for gene silencing in human, mouse, rat MAGI3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MAGI3

Clone Products:		OriGene clones in human, mouse for MAGI3 (see all 12) OriGene ORF clones in mouse, rat for MAGI3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): MAGI3 (NM_001142782)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGI3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGI3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MAGI3
		Browse ESI BIO Cell Lines and PureStem Progenitors for MAGI3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGI3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

MAGI3_HUMAN, Q5TCQ9: Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Nucleus (By

similarity). Note=Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells,

it localizes at tight junctions (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
nucleus	3
cytosol	2
mitochondrion	1

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Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005911	cell-cell junction	--	--
GO:0005923	tight junction	IEA	--
GO:0016020	membrane	NAS	10748157

MAGI3 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MAGI3 About

See pathways by source

SuperPath

Contained pathways About

Endometrial cancer

Signal transduction PTEN pathway

0.45

Wnt signaling pathway (KEGG)

Wnt Signaling Pathway NetPath

0.37

Ras signaling pathway

Rap1 signaling pathway

0.36

Tight junction

Tight junction

Pathways by source See SuperPaths
Show all pathways

3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAGI3

	Sertoli-Sertoli Cell Junction Dynamics
	Epithelial Tight Junctions
	PTEN Pathway

1 GeneGo (Thomson Reuters) Pathway for MAGI3

Signal transduction PTEN pathway

1 BioSystems Pathway for MAGI3

Wnt Signaling Pathway NetPath

2 Kegg Pathways (Kegg details for MAGI3):

	Rap1 signaling pathway
	Tight junction

MAGI3 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MAGI3
Interactions:

Search GeneGlobe Interaction Network for MAGI3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for MAGI3 (Q5TCQ9^{1, 2, 3} ENSP00000304604⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 73)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADRB2	P07550¹^,²^,³, ENSP00000305372⁴	EBI-310506,EBI-491169 MINT-7716320 MINT-7716382 MINT-7716556 MINT-7716470 MINT-7716630 MINT-7716422 MINT-7716450 MINT-7716335 MINT-7716502 I2D: score=2 STRING: ENSP00000305372
MED28	Q9H204¹^,²^,³, ENSP00000237380⁴	EBI-310506,EBI-514199 MINT-7041950 MINT-7041908 I2D: score=1 STRING: ENSP00000237380
PTEN	P60484²^,³, ENSP00000361021⁴	MINT-1796736 MINT-1796842 MINT-72925 MINT-1796814 MINT-72923 MINT-72927 I2D: score=4 STRING: ENSP00000361021
BAI1	O14514²^,³, ENSP00000313046⁴	MINT-72930 MINT-1796764 I2D: score=4 STRING: ENSP00000313046
TJP1	Q07157²^,³, ENSP00000281537⁴	MINT-1796870 MINT-6800622 I2D: score=1 STRING: ENSP00000281537

About this table

Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	NAS	10748157
GO:0016032	viral process	IEA	--
GO:0019048	modulation by virus of host morphology or physiology	--	--
GO:0035556	intracellular signal transduction	NAS	10748157
GO:0043507	positive regulation of JUN kinase activity	IEA	--

MAGI3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for MAGI3

4 Novoseek inferred chemical compound relationships for MAGI3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
guanylate	86.6	29	10779526 (1), 14770369 (1), 17267446 (1), 18847477 (1) (see all 26)
valine	30	1	16316992 (1)
glutamate	9.07	2	18367167 (1), 10595517 (1)
tyrosine	0	6	12615970 (3), 16814777 (1)

MAGI3 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MAGI3 gene (3 alternative transcripts):

NM_020965.2 NM_001142782.1 NM_152900.2

Unigene Cluster for MAGI3:

Membrane associated guanylate kinase, WW and PDZ domain containing 3

Hs.486189 [show with all ESTs]

Unigene Representative Sequence: NM_152900

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369617(uc001edh.3) ENST00000307546(uc001edk.3 uc009wgo.3)

ENST00000369615(uc001edi.4 uc010owm.2 uc001edj.3) ENST00000369611

ENST00000486456 ENST00000477955

miRNA Products:		Block miRNA regulation of human, mouse, rat MAGI3 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MAGI3 (see all 24):
		hsa-miR-142-5p hsa-miR-30c hsa-miR-1271 hsa-miR-30d hsa-miR-340 hsa-miR-410 hsa-miR-548m hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: MAGI3 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat MAGI3

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		GenScript: all cDNA clones in your preferred vector (see all 2): MAGI3 (NM_001142782)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGI3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGI3

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for MAGI3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat MAGI3
		QuantiTect SYBR Green Assays in human, mouse, rat MAGI3
		QuantiFast Probe-based Assays in human, mouse, rat MAGI3

Additional mRNA sequence:

AB046854.1 AF213259.1 AK026417.1 AK311589.1 BC130409.1 BC144144.1

8 DOTS entries:

DT.313515 DT.102843014 DT.305513 DT.100754724 DT.91660829 DT.121414088 DT.121414139 DT.95257128

Selected AceView cDNA sequences (see all 99):

BX953520 AB046854 BM728293 AA007627 BX115216 BQ011994 AA447960 AI375078

BM728137 AI453065 AI634790 AI738585 AW512723 AA007664 AA424967 BF061992

AI696507 AA812598 AA992863 AI352360 R85666 AI521837 BX507970 NM_020965

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MAGI3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

MAGI3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MAGI3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.486189

UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9

Tissue specificity: Widely expressed

Custom PCR Arrays for MAGI3

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		QuantiFast Probe-based Assays in human, mouse, rat MAGI3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGI3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MAGI3 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Magi3^{1 , 5}	membrane associated guanylate kinase, WW and PDZ domain more^{1, 5}	87.29(n)¹ 87.08(a)¹		3 (45.52 cM)⁵ 99470¹ NM_001159354.1¹ NP_001152826.1¹ 104013259⁵
chicken (Gallus gallus)	Aves	MAGI3¹	membrane associated guanylate kinase, WW and PDZ domain more	77.88(n) 85.08(a)		419877 NM_001012697.1 NP_001012715.1
lizard (Anolis carolinensis)	Reptilia	MAGI3⁶	membrane associated guanylate kinase, WW and PDZ d...	71(a)	1 ↔ 1	4(139398135-139609548)
tropical clawed frog (Xenopus tropicalis)	Amphibia	magi3¹	membrane associated guanylate kinase, WW and PDZ domain more	72.38(n) 81.29(a)		100036692 NM_001097243.1 NP_001090712.1
zebrafish (Danio rerio)	Actinopterygii	wufi36a10²	Transcribed sequence with weak similarity to protein more	77.36(n)		57072019
fruit fly (Drosophila melanogaster)	Insecta	Magi⁶	Magi	26(a)	1 → many	2R(17016968-17030067)
worm (Caenorhabditis elegans)	Secernentea	magi-1⁶	Protein MAGI-1, isoform c (magi-1) mRNA, complete ...	32(a)	1 → many	IV(11715090-11729281) WBGene00010444

ENSEMBL Gene Tree for MAGI3 (if available)
TreeFam Gene Tree for MAGI3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MAGI3 gene

MAGI2² SAV1² MAGIX² MAGI1²

3 SIMAP similar genes for MAGI3 using alignment to 1 protein entry: MAGI3_HUMAN:

MAGI2 SYNJ2BP MAGI1

MAGI3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187323354^1,2		--	113931582(+)	`CCTGCC/TCACAT`	2	--	us2k¹		0	--	--	--	--
rs79324505^1,2	F	--	113931648(+)	`ACGAAA/GTCACT`	2	--	us2k¹		1		WA	118
rs6537788^1,2	C,F,A,H	--	113931699(+)	`GTTTTA/GTAAGG`	2	--	us2k¹ tfbs³		20		NS EA NA CSA WA	2385
rs1112543^1,2	C,F,A,H	--	113931805(+)	`CCACTT/CGAGGG`	2	--	us2k¹ tfbs³		20		NS EA NA	2418
rs148184597^1,2		--	113931915(+)	`AAGAGC/TGTAAG`	2	--	us2k¹		0	--	--	--	--
rs192236234^1,2		--	113932009(+)	`TTCGTC/TCTCCC`	2	--	us2k¹		0	--	--	--	--
rs116356531^1,2	F	--	113932251(+)	`ACAATA/GTCTAA`	2	--	us2k¹		1		WA	118
rs146866049^1,2		--	113932277(+)	`GTCAT-/CAGCAGCA`	2	--	us2k¹		0	--	--	--	--
rs72687913^1,2	C	--	113932279(+)	`CATCAG/TCAGCA`	2	--	us2k¹		0	--	--	--	--
rs141142328^1,2		--	113932466(+)	`CAACCA/GGACTC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MAGI3 (113933371 - 114183371 bp, first 250kb of MAGI3)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for MAGI3 (see all 15): About this table

Variant ID	Type	Subtype	PubMed ID
esv2716429	CNV	Deletion	23290073
esv2664101	CNV	Deletion	23128226
esv2676508	CNV	Deletion	23128226
nsv435905	CNV	Deletion	17901297
esv2716440	CNV	Deletion	23290073
esv2670349	CNV	Deletion	23128226
esv1062910	CNV	Insertion	17803354
esv1673662	CNV	Insertion	17803354
esv1257635	CNV	Insertion	17803354
nsv437013	CNV	Loss	16327808

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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5 diseases for MAGI3:
About MalaCards

human t-cell leukemia virus type 1 t-cell leukemia b-cell lymphomas obesity

leukemia

MAGI3 for disorders About GeneDecksing

1 Novoseek inferred disease relationship for MAGI3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	3	10748157 (1), 9434093 (1), 9838122 (1)

Genetic Association Database (GAD): MAGI3
Human Genome Epidemiology (HuGE) Navigator: MAGI3 (3 documents)

Export disorders for MAGI3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MAGI3 gene, integrated from 10 sources (see all 56):
(articles sorted by number of sources associating them with MAGI3)

Utopia: connect your pdf to the dynamic
world of online information

Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. (PubMed id 10748157)^{1, 2, 3, 9} Wu Y.... Lasky L.A. (J. Biol. Chem. 2000)
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{1, 2, 3} Nagase T.... Ohara O. (DNA Res. 2000)
MAGI-3 regulates LPA-induced activation of Erk and RhoA. (PubMed id 16904289)^{1, 2, 9} Zhang H.... Yun C.C. (Cell. Signal. 2007)
Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. (PubMed id 15652357)^{1, 2, 9} Franklin J.L.... Coffey R.J. (Exp. Cell Res. 2005)
Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. (PubMed id 12140759)^{1, 2, 9} Thomas M....Banks L. (Oncogene 2002)
MAGI-1: a widely expressed, alternatively spliced tight junction protein. (PubMed id 11969287)^{1, 2, 9} Laura R.P.... Lasky L.A. (Exp. Cell Res. 2002)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3. (PubMed id 15003862)^{2, 9} Ohashi M....Fujii M. (Virology 2004)
Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins. (PubMed id 12615970)^{1, 9} Adamsky K....Peles E. (J. Cell. Sci. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 260425	HGNC: 29647	AceView: MAGI-3	Ensembl:ENSG00000081026	euGenes: HUgn260425
ECgene: MAGI3	Kegg: 260425	H-InvDB: MAGI3

(According to HUGE)
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HUGE: KIAA1634

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MAGI3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MAGI3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MAGI3 gene:
Search GeneIP for patents involving MAGI3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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