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MAGI3 Gene

protein-coding   GIFtS: 53
GCID: GC01P113933

Membrane Associated Guanylate Kinase, WW And PDZ Domain...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing
31 2
     Membrane-Associated Guanylate Kinase, WW And PDZ Domain-Containing Protein
32
Membrane-Associated Guanylate Kinase Inverted 32 3     Membrane-Associated Guanylate Kinase-Related 32
MAGI-32 3     KIAA16343
dJ730K3.22     

External Ids:    HGNC: 296471   Entrez Gene: 2604252   Ensembl: ENSG000000810267   UniProtKB: Q5TCQ93   

Export aliases for MAGI3 gene to outside databases

Previous GC identifers: GC01P113646 GC01P113734 GC01P111791


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAGI3 Gene:
MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3) is a protein-coding gene. GO annotations related to this gene include guanylate kinase activity and frizzled binding. An important paralog of this gene is MAGI2.

UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9
Function: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling
processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine
phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma
membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates
the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction
with FZD4 and VANGL2

Gene Wiki entry for MAGI3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAGI3 gene promoter:
         TBP   Egr-1   STAT5A   Cdc5   Evi-1   Egr-4   Meis-1b   TFIID   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAGI3 promoter sequence
   Search Chromatin IP Primers for MAGI3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGI3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p12-p11.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p12-p11.2

MAGI3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGI3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P113933:  view genomic region     (about GC identifiers)

Start:
113,933,371 bp from pter      End:
114,228,545 bp from pter
Size:
295,175 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9 (See protein sequence)
Recommended Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3  
Size: 1506 amino acids; 165608 Da
Subunit: Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with unidentified tyrosine
phosphorylated proteins (By similarity). Interacts with BAI1, LPAR2/EDG4, GRIN2B and PTEN. In case of infection,
interacts with HTLV TAX1 protein, possibly affecting the transformation ability of TAX1. Does not interact with
HTLV TAX2 or TAX3 proteins. In case of infection, interacts with HPV type 16 and HPV type 18 E6 protein
Miscellaneous: MAGI3 PDZ domains are used to design peptide ligands that bind and inhibit PDZ domains
Sequence caution: Sequence=BAB15479.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15479.1; Type=Frameshift; Positions=1373;
1 PDB 3D structure from and Proteopedia for MAGI3:
3SOE (3D)    
Secondary accessions: Q5TCQ8 Q5TCR0 Q9H2V6 Q9H5Y8 Q9HBC4 Q9HCD8
Alternative splicing: 4 isoforms:  Q5TCQ9-1   Q5TCQ9-2   Q5TCQ9-3   Q5TCQ9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAGI3: NX_Q5TCQ9

Explore proteomics data for MAGI3 at MOPED

Post-translational modifications: 

  • Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation
    is independent of E6AP ubiquitin ligase complex1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAGI3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136254.1  NP_690864.2  

    ENSEMBL proteins: 
     ENSP00000358630   ENSP00000304604   ENSP00000358628   ENSP00000358624  

    MAGI3 Human Recombinant Protein Products:

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    Novus Biologicals MAGI3 Protein
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    Cloud-Clone Corp. Proteins for MAGI3

     
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    MAGI3 Assay Products:

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    Search eBioscience for ELISAs for MAGI3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR008144 Guanylate_kin-like
     IPR008145 GK/Ca_channel_bsu
     IPR027417 P-loop_NTPase
     IPR001478 PDZ
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q5TCQ9

    ProtoNet protein and cluster: Q5TCQ9

    UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9
    Similarity: Belongs to the MAGUK family
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 6 PDZ (DHR) domains
    Similarity: Contains 2 WW domains


    Find genes that share domains with MAGI3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAGI3_HUMAN, Q5TCQ9
    Function: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling
    processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine
    phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma
    membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates
    the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction
    with FZD4 and VANGL2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004385guanylate kinase activity NAS10748157
    GO:0005109frizzled binding IEA--
    GO:0005515protein binding IPI16316992
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with MAGI3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MAGI3:
     Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAGI3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAGI3
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    Selected qRT-PCR Assays for microRNAs that regulate MAGI3 (see all 24):
    hsa-miR-142-5p hsa-miR-30c hsa-miR-1271 hsa-miR-30d hsa-miR-340 hsa-miR-410 hsa-miR-548m hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMAGI3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAGI3

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGI3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAGI3_HUMAN, Q5TCQ9: Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Nucleus (By
    similarity). Note=Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells,
    it localizes at tight junctions (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--
    GO:0005911cell-cell junction ----
    GO:0005923tight junction IEA--
    GO:0016020membrane NAS10748157

    Find genes that share ontologies with MAGI3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAGI3 About    
    See pathways by source

    SuperPathContained pathways About
    1Endometrial cancer
    Signal transduction PTEN pathway0.45
    2Wnt signaling pathway (KEGG)
    Wnt Signaling Pathway NetPath0.37
    3Ras signaling pathway
    Rap1 signaling pathway0.36
    4Tight junction
    Tight junction


    Find genes that share SuperPaths with MAGI3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAGI3
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    PTEN Pathway

    1 GeneGo (Thomson Reuters) Pathway for MAGI3
        Signal transduction PTEN pathway

    1 BioSystems Pathway for MAGI3
        Wnt Signaling Pathway NetPath


    2 Kegg Pathways  (Kegg details for MAGI3):
        Rap1 signaling pathway
    Tight junction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAGI3
    Interactions:

        Search GeneGlobe Interaction Network for MAGI3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAGI3 (Q5TCQ91, 2, 3 ENSP000003046044) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRB2P075501, 2, 3, ENSP000003053724EBI-310506,EBI-491169 MINT-7716320 MINT-7716382 MINT-7716556 MINT-7716470 MINT-7716630 MINT-7716422 MINT-7716450 MINT-7716335 MINT-7716502 I2D: score=2 STRING: ENSP00000305372
    MED28Q9H2041, 2, 3, ENSP000002373804EBI-310506,EBI-514199 MINT-7041950 MINT-7041908 I2D: score=1 STRING: ENSP00000237380
    PTENP604842, 3, ENSP000003610214MINT-1796736 MINT-1796842 MINT-72925 MINT-1796814 MINT-72923 MINT-72927 I2D: score=4 STRING: ENSP00000361021
    BAI1O145142, 3, ENSP000003130464MINT-72930 MINT-1796764 I2D: score=4 STRING: ENSP00000313046
    TJP1Q071572, 3, ENSP000002815374MINT-1796870 MINT-6800622 I2D: score=1 STRING: ENSP00000281537
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process NAS10748157
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0035556intracellular signal transduction NAS10748157
    GO:0043507positive regulation of JUN kinase activity IEA--

    Find genes that share ontologies with MAGI3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAGI3

    4 Novoseek inferred chemical compound relationships for MAGI3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 86.6 29 10779526 (1), 14770369 (1), 17267446 (1), 18847477 (1) (see all 26)
    valine 30 1 16316992 (1)
    glutamate 9.07 2 18367167 (1), 10595517 (1)
    tyrosine 0 6 12615970 (3), 16814777 (1)



    Find genes that share compounds with MAGI3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAGI3 gene (3 alternative transcripts): 
    NM_020965.2  NM_001142782.1  NM_152900.2  

    Unigene Cluster for MAGI3:

    Membrane associated guanylate kinase, WW and PDZ domain containing 3
    Hs.486189  [show with all ESTs]
    Unigene Representative Sequence: NM_152900
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369617(uc001edh.3) ENST00000307546(uc001edk.3 uc009wgo.3)
    ENST00000369615(uc001edi.4 uc010owm.2 uc001edj.3) ENST00000369611
    ENST00000486456 ENST00000477955
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    hsa-miR-142-5p hsa-miR-30c hsa-miR-1271 hsa-miR-30d hsa-miR-340 hsa-miR-410 hsa-miR-548m hsa-miR-30a
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    Additional mRNA sequence: 

    AB046854.1 AF213259.1 AK026417.1 AK311589.1 BC130409.1 BC144144.1 

    8 DOTS entries:

    DT.313515  DT.102843014  DT.305513  DT.100754724  DT.91660829  DT.121414088  DT.121414139  DT.95257128 

    Selected AceView cDNA sequences (see all 99):

    BX953520 AB046854 BM728293 AA007627 BX115216 BQ011994 AA447960 AI375078 
    BM728137 AI453065 AI634790 AI738585 AW512723 AA007664 AA424967 BF061992 
    AI696507 AA812598 AA992863 AI352360 R85666 AI521837 BX507970 NM_020965 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAGI3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAGI3 Expression
    About this image

    MAGI3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAGI3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.486189

    UniProtKB/Swiss-Prot: MAGI3_HUMAN, Q5TCQ9
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGI3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAGI3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Magi31 , 5 membrane associated guanylate kinase, WW and PDZ domain more1, 5 87.29(n)1
    87.08(a)1
      3 (45.52 cM)5
    994701  NM_001159354.11  NP_001152826.11 
     1040132595 
    chicken
    (Gallus gallus)
    Aves MAGI31 membrane associated guanylate kinase, WW and PDZ domain more 77.88(n)
    85.08(a)
      419877  NM_001012697.1  NP_001012715.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAGI36
    membrane associated guanylate kinase, WW and PDZ d...
    71(a)
    1 ↔ 1
    4(139398135-139609548)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia magi31 membrane associated guanylate kinase, WW and PDZ domain more 72.38(n)
    81.29(a)
      100036692  NM_001097243.1  NP_001090712.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi36a102 Transcribed sequence with weak similarity to protein more 77.36(n)    57072019 
    fruit fly
    (Drosophila melanogaster)
    Insecta Magi6
    Magi
    26(a)
    1 → many
    2R(17016968-17030067)
    worm
    (Caenorhabditis elegans)
    Secernentea magi-16
    Protein MAGI-1, isoform c (magi-1) mRNA, complete ...
    32(a)
    1 → many
    IV(11715090-11729281) WBGene00010444


    ENSEMBL Gene Tree for MAGI3 (if available)
    TreeFam Gene Tree for MAGI3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAGI3 gene
    MAGI22  SAV12  MAGIX2  MAGI12  
    3 SIMAP similar genes for MAGI3 using alignment to 1 protein entry:     MAGI3_HUMAN:
    MAGI2    SYNJ2BP    MAGI1

    Find genes that share paralogs with MAGI3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAGI3 (see all 5097)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873233541,2
    --113931582(+) CCTGCC/TCACAT 2 -- us2k10--------
    rs793245051,2
    F--113931648(+) ACGAAA/GTCACT 2 -- us2k11Minor allele frequency- G:0.09WA 118
    rs65377881,2
    C,F,A,H--113931699(+) GTTTTA/GTAAGG 2 -- us2k1 tfbs320Minor allele frequency- G:0.05NS EA NA CSA WA 2385
    rs11125431,2
    C,F,A,H--113931805(+) CCACTT/CGAGGG 2 -- us2k1 tfbs320Minor allele frequency- C:0.29NS EA NA 2418
    rs1481845971,2
    --113931915(+) AAGAGC/TGTAAG 2 -- us2k10--------
    rs1922362341,2
    --113932009(+) TTCGTC/TCTCCC 2 -- us2k10--------
    rs1163565311,2
    F--113932251(+) ACAATA/GTCTAA 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1468660491,2
    --113932277(+) GTCAT-/CAGCAGCA 2 -- us2k10--------
    rs726879131,2
    C--113932279(+) CATCAG/TCAGCA 2 -- us2k10--------
    rs1411423281,2
    --113932466(+) CAACCA/GGACTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAGI3 (113933371 - 114183371 bp, first 250kb of MAGI3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAGI3 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716429CNV Deletion23290073
    esv2664101CNV Deletion23128226
    esv2676508CNV Deletion23128226
    nsv435905CNV Deletion17901297
    esv2716440CNV Deletion23290073
    esv2670349CNV Deletion23128226
    esv1062910CNV Insertion17803354
    esv1673662CNV Insertion17803354
    esv1257635CNV Insertion17803354
    nsv437013CNV Loss16327808

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAGI3
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGI3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with MAGI3           About GenesLikeMe

    1 Novoseek inferred disease relationship for MAGI3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 10748157 (1), 9434093 (1), 9838122 (1)

    Genetic Association Database (GAD): MAGI3
    Human Genome Epidemiology (HuGE) Navigator: MAGI3 (3 documents)

    Export disorders for MAGI3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAGI3 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with MAGI3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. (PubMed id 10748157)1, 2, 3, 9 Wu Y.... Lasky L.A. (J. Biol. Chem. 2000)
    2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. MAGI-3 regulates LPA-induced activation of Erk and RhoA. (PubMed id 16904289)1, 2, 9 Zhang H.... Yun C.C. (Cell. Signal. 2007)
    4. Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. (PubMed id 15652357)1, 2, 9 Franklin J.L.... Coffey R.J. (Exp. Cell Res. 2005)
    5. Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. (PubMed id 12140759)1, 2, 9 Thomas M....Banks L. (Oncogene 2002)
    6. MAGI-1: a widely expressed, alternatively spliced tight junction protein. (PubMed id 11969287)1, 2, 9 Laura R.P.... Lasky L.A. (Exp. Cell Res. 2002)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3. (PubMed id 15003862)2, 9 Ohashi M....Fujii M. (Virology 2004)
    10. Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins. (PubMed id 12615970)1, 9 Adamsky K....Peles E. (J. Cell. Sci. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 260425 HGNC: 29647 AceView: MAGI-3 Ensembl:ENSG00000081026 euGenes: HUgn260425
    ECgene: MAGI3 Kegg: 260425 H-InvDB: MAGI3

    (According to HUGE)
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    HUGE: KIAA1634

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAGI3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAGI3 gene:
    Search GeneIP for patents involving MAGI3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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