Aliases for MAGI2 Gene
External Ids for MAGI2 Gene
Previous GeneCards Identifiers for MAGI2 Gene
The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAGI2 Gene
MAGI2 (Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 2) is a Protein Coding gene. Diseases associated with MAGI2 include ohtahara syndrome and usher syndrome. Among its related pathways are Ras signaling pathway and PAK Pathway. GO annotations related to this gene include signal transducer activity and SMAD binding. An important paralog of this gene is MAGI3.
UniProtKB/Swiss-Prot for MAGI2 Gene
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.