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MAGI2 Gene

protein-coding GIFtS: 59

GC07M077484

membrane associated guanylate kinase, WW and PDZ domain containing 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACVRINP1 ^³
ACVRIP1 ^¹, ²
AIP1 ^¹, ², ³
ARIP1 ^¹, ²
KIAA0705 ^¹, ³
MAGI-2 ^¹, ², ³
SSCAM ^²

Descriptions
Atrophin-1-interacting protein 1 ^³
Atrophin-1-interacting protein A ^³
Membrane-associated guanylate kinase inverted 2 ^³
activin receptor interacting protein 1 ^²
atrophin 1 interacting protein 1 ^²
atrophin-1 interacting protein A ^²
membrane associated guanylate kinase, WW and PDZ domain containing 2 ^²

External Ids
HGNC: 18957¹
Entrez Gene: 9863²
UniProtKB: Q86UL8³
Ensembl: ENSG00000187391⁷

Search outside databases for aliases for MAGI2 gene

Previous GC identifer: GC07M077292

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAGI2:

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine

repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This

encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple

PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue

(MAGUK) family. [provided by RefSeq]

UniProtKB/Swiss-Prot: MAGI2_HUMAN, Q86UL8

Function: Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter

receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in

neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation

Gene Wiki entry for MAGI2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAGI2 gene

Entrez Gene cytogenetic band: 7q21 Ensembl cytogenetic band: 7q21.11 HGNC cytogenetic band: 7q21

MAGI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M077484: (about GC identifiers)

Start:	77,484,310 bp from pter
End:	78,920,826 bp from pter
Size:	1,436,517 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 76,978,436-78,414,480

RefSeq DNA sequence:

NC_000007.12 NT_007933.14 NT_079595.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MAGI2_HUMAN, Q86UL8 (See protein sequence)

Recommended Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Size: 1455 amino acids; 158754 Da

Subunit: Interacts via its WW domains with DRPLA. Interacts via its second PDZ domain with PTEN

unphosphorylated C-terminus; this interaction diminishes the degradation rate of PTEN (By

similarity). Interacts through its guanylate kinase domain with DLGAP1 (By similarity). Interacts

through the PDZ domains with GRIN2A, GRID2 and NLGN1 (By similarity). Interacts with CTNND2,

CTNNB1, MAGUIN-1, ACVR2A, SMAD2 and SMAD3 (By similarity). Part of a complex consisting of AIP1,

ACVR2A, ACVR1B and SMAD3 (By similarity). May interact with HTR2A (By similarity). Interacts with

IGSF9, RAPGEF2 and HTR4 (By similarity). Interacts with DDN

Subcellular location: Cell junction, synapse, synaptosome (By similarity). Cell membrane;

Peripheral membrane protein (By similarity). Note=Membrane-associated in synaptosomes (By

similarity)

PDB structures from and Proteopedia :

1UEP (3D)

1UEQ (3D)

1UEW (3D)

1UJV (3D)

1WFV (3D)

Secondary accessions: A4D1C1 A7E2C3 O60434 O60510 Q86UI7 Q9NP44 Q9UDQ5 Q9UDU1

Alternative splicing: 2 isoforms: Q86UL8-1 Q86UL8-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_036433.2

ENSEMBL proteins:

ENSP00000346151 ENSP00000385753

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (AIP1)
	Human Recombinant Proteins from Abnova (MAGI2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0019717	synaptosome	IEA	--
GO:0030054	cell junction	IEA	--
GO:0045202	synapse	IEA	--

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Antibodies for MAGI2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MAGI2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (AIP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAGI2)
	Novus Biologicals Antibodies for MAGI2

Assays for MAGI2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q86UL8

ProtoNet protein and cluster: Q86UL8

1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain

UniProtKB/Swiss-Prot: MAGI2_HUMAN, Q86UL8

Similarity: Belongs to the MAGUK family

Similarity: Contains 1 guanylate kinase-like domain

Similarity: Contains 6 PDZ (DHR) domains

Similarity: Contains 2 WW domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGI2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAGI2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012301

Applied Biosystems Silencer® siRNAs for MAGI2

Sigma-Aldrich siRNA and siRNA Panels for MAGI2

Sigma-Aldrich shRNA for MAGI2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_012301
Myc/DDK tagged cDNA clone in CMV expression vector: NM_012301
untagged cDNA clone in CMV expression vector: NM_012301

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_012301

UniProtKB/Swiss-Prot: MAGI2_HUMAN, Q86UL8

Function: Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter

receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in

neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Magi2):

lethality-prenatal/perinatal

nervous system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	9647693
GO:0019902	phosphatase binding	IPI	10760291

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for MAGI2 (Your Favorite Gene powered by Ingenuity)

PTEN Signaling
Tight Junction Signaling

GeneDecks MAGI2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MAGI2

5/8 Interacting proteins for MAGI2 (Q86UL8^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 8 )
Interactant Interaction Details
GeneCard External ID(s)
ADRB1 P08588¹^,² EBI-311035, EBI-991009 MINT-58358 MINT-58357 MINT-58359 MINT-58360 MINT-58361 EBI-311035, EBI-991009 MINT-58358 MINT-58357 MINT-58359 MINT-58360 MINT-58361
AMOTL1 Q8IY63¹ EBI-311035, EBI-1057112
POLR2A P24928¹ EBI-311035, EBI-295301
POLR2B P30876¹ EBI-311035, EBI-394712
ADRB1 P08588¹^,² EBI-311035, EBI-991009 MINT-58358 MINT-58357 MINT-58359 MINT-58360 MINT-58361 EBI-311035, EBI-991009 MINT-58358 MINT-58357 MINT-58359 MINT-58360 MINT-58361
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGI2
1 Novoseek chemical compound relationship for MAGI2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
guanylate	69.85	12	11526121 (3), 18565486 (1), 10760291 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGI2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAGI2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012301

Sigma-Aldrich siRNA and siRNA Panels for MAGI2

Sigma-Aldrich shRNA for MAGI2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_012301

REFSEQ mRNAs for MAGI2 gene:

NM_012301.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_012301

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012301
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012301
                                 untagged cDNA clone in CMV expression vector: NM_012301

Additional cDNA sequence:

AB014605.2 AF038563.1 AK297353.1 AK297580.1 AK298988.1 AK308685.1 AK309012.1 BC150277.1

9 DOTS entries:

DT.92422073 DT.210404 DT.75183613 DT.75135516 DT.97825277 DT.95350132 DT.121038497 DT.91978936

DT.99987070

1 AceView cDNA sequence:

BX645880

highest scoring ESTs for MAGI2:

AB014605 BX645880 AA448219 AA448362 AA890379 AA976171 AI023086 AI038850 AI142921 AI263875

Unigene Cluster for MAGI2:

Membrane associated guanylate kinase, WW and PDZ domain containing 2

Hs.603842 [show with all ESTs]

Unigene Representative Sequence: NM_012301

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000354212 ENST00000404825

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAGI2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAGI2

¹ / ² / ³

5 probe-sets matching MAGI2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34257_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB014605	1.00	0.87	0.94	1
209737_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB014605	1.00	0.87	0.94	1
207702_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012301	0.60	1.00	0.82	1
209737_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207702_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MAGI2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATTAATAGT

SOURCE GeneReport for Unigene cluster: Hs.603842
UniProtKB/Swiss-Prot: MAGI2_HUMAN, Q86UL8
Tissue specificity: Specifically expressed in brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAGI2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAGI2¹	--	membrane associated guanylate kinase, WW and PDZ domain more	89.66(n) 93.1(a)	475904 XM_533111.2 XP_533111.2
chimpanzee (Pan troglodytes)	MAGI2¹	--	membrane associated guanylate kinase, WW and PDZ domain more	95.29(n) 94.66(a)	463498 XM_519172.2 XP_519172.2
cow (Bos taurus)	MAGI2¹	--	membrane associated guanylate kinase, WW and PDZ domain more	90.64(n) 93.41(a)	517124 XM_595287.3 XP_595287.3
rat (Rattus norvegicus)	Magi2¹	--	membrane associated guanylate kinase, WW and PDZ domain more	92.12(n) 97.96(a)	113970 NM_053621.1 NP_446073.1
mouse (Mus musculus)	Magi2^{1, 5}	5⁵	membrane associated guanylate kinase, WW and PDZ domain more^{1, 5}	92.31(n)¹ 96.39(a)¹	50791¹ XM_001000876.2¹ XP_001000876.1¹ AA275788⁵ AB029485⁵ (see all 13)

About this table Species with no ortholog for MAGI2

ENSEMBL Gene Tree for MAGI2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAGI2 gene

ENSG00000151276² MAGIX² MAGI3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/9572 NCBI SNPs in MAGI2 are shown (see all 9572 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 3137)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4473963^1,2	A,C,F,H	77485258(+)	`GCTAAT/CTAATT`	1	--	ut3¹		4	EU EA WA	402
	rs10231884^1,2	A,C,F,H	78922736(+)	`TTAAAA/GAAAGA`	1	--	ng3¹		8	EU EA WA	826
	rs2428919^1,2	A,F	77484238(+)	`GTCGAT/CGAAAA`	1	--	ng5¹		2	NA	182
	rs17152525^1,2	F,H	78921916(+)	`TGACAA/GTTTAA`	1	--	ng3¹		7	NA EU EA WA	558
	rs1990098^1,2	H,O	78921790(+)	`CGGTTG/TTCTGG`	1	--	ng3¹		3	EU EA	290
	rs10279502^1,2	F,H	78920673(+)	`GAAGAA/CCAGCA`	1	--	ut5¹ trp³		4	EU EA WA	420
	rs13233158^1,2	H	78920855(+)	`gtggtG/Agtggc`	1	--	ng3¹		4	EU EA WA	420
--	rs3185768^1,2	F	77486248(-)	`TCCCCA/CCTGCA`	1	--	ut3¹		1	MN	184
	rs1009524^1,2	A,C,F,H,O	77627339(-)	`GAGAAT/CGAGGG`	1	N/N	syn¹		11	MN EU EA WA NA	2396
	rs2074641^1,2	C,F,H,O	77594516(+)	`TCCAGC/TAGGGG`	1	L/L	syn¹ ese³		9	EA NA EU WA	1944

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HapMap Linkage Disequilibrium images for MAGI2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606382

Human Gene Mutation Database: MAGI2
Human Genome Epidemiology Navigator: MAGI2 (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/28 PubMed articles for MAGI2 gene (see all 28 ):

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{2, 3, 4} Ishikawa K....Ohara O. (1998)
Evidence for regulation of the PTEN tumor suppressor by a membrane- localized multi-PDZ domain containing scaffold protein MAGI-2. (PubMed id 10760291)^{1, 3, 4} Wu X.... Whang Y.E. (2000)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{3, 4} Scherer S.W....Tsui L.C. (2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. (PubMed id 11707428)^{3, 4} Vazquez F....Sellers W.R. (2001)
Identification and characterization of a PDZ protein that interacts with activin type II receptors. (PubMed id 10681527)^{2, 3} Shoji H....Sugino H. (2000)
Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. (PubMed id 9647693)^{3, 4} Wood J.D....Ross C.A. (1998)
beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. (PubMed id 11526121)^{1, 3} Xu J....Hall R.A. (2001)
MAGI2 genetic variation and inflammatory bowel disease. (PubMed id 18720471)³ McGovern D.P....Rotter J.I. (2009)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)³ Trynka G....Wijmenga C. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9863	HGNC: 18957	AceView: AIP1.2	Ensembl:ENSG00000187391	euGenes: HUgn9863
ECgene: MAGI2	H-InvDB: MAGI2

(According to HUGE)
About This Section

HUGE: KIAA0705

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for MAGI2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MAGI2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAGI2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAGI2		Antibodies for MAGI2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MAGI2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MAGI2)
	Antibodies (MAGI2)
	Chimera RNAi (MAGI2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (AIP1)

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Search Tocris compounds for MAGI2

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Antibodies for MAGI2

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MAGI2 Gene at Home site.
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MAGI2 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for MAGI2

Summaries
for MAGI2

Genomic Location
for MAGI2

Proteins
for MAGI2

Protein Domains/
Families
for MAGI2

Gene Function
for MAGI2

Pathways & Interactions
for MAGI2

Drugs & Compounds
for MAGI2

Transcripts
for MAGI2

Expression
for MAGI2

Orthologs
for MAGI2

Paralogs
for MAGI2

SNPs/Variants
for MAGI2

Disorders & Mutations
for MAGI2

Medical News
for MAGI2

Publications
for MAGI2

Search for MAGI2

Genome Databases showing MAGI2

Other Databases showing MAGI2

Specialized Databases showing MAGI2

Licensable Technologies
for MAGI2

Services
for MAGI2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAGI2 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor MAGI2

Summariesfor MAGI2

Genomic Locationfor MAGI2

Proteinsfor MAGI2

Protein Domains/Familiesfor MAGI2

Gene Functionfor MAGI2

Pathways & Interactionsfor MAGI2

Drugs & Compoundsfor MAGI2

Transcriptsfor MAGI2

Expression for MAGI2

Orthologsfor MAGI2

Paralogsfor MAGI2

SNPs/Variantsfor MAGI2

Disorders & Mutationsfor MAGI2

Medical Newsfor MAGI2

Publicationsfor MAGI2

Search for MAGI2

Genome Databases showing MAGI2

Other Databases showing MAGI2

Specialized Databases showing MAGI2

Licensable Technologiesfor MAGI2

Servicesfor MAGI2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAGI2

Summaries
for MAGI2

Genomic Location
for MAGI2

Proteins
for MAGI2

Protein Domains/
Families
for MAGI2

Gene Function
for MAGI2

Pathways & Interactions
for MAGI2

Drugs & Compounds
for MAGI2

Transcripts
for MAGI2

Expression
for MAGI2

Orthologs
for MAGI2

Paralogs
for MAGI2

SNPs/Variants
for MAGI2

Disorders & Mutations
for MAGI2

Medical News
for MAGI2

Publications
for MAGI2

Licensable Technologies
for MAGI2

Services
for MAGI2