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Aliases for MAGI1 Gene

Aliases for MAGI1 Gene

  • Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1 2 3
  • BAI1-Associated Protein 1 2 3 4
  • BAIAP1 3 4 6
  • TNRC19 3 4 6
  • WWP3 3 4 6
  • Membrane-Associated Guanylate Kinase Inverted 1 3 4
  • Trinucleotide Repeat-Containing Gene 19 Protein 3 4
  • Atrophin-1-Interacting Protein 3 3 4
  • WW Domain-Containing Protein 3 3 4
  • MAGI-1 3 4
  • AIP-3 3 4
  • BAP-1 3 4
  • AIP3 3 4
  • BAP1 3 4
  • Membrane-Associated Guanylate Kinase, WW And PDZ Domain-Containing Protein 1 3
  • Magi1d 3

External Ids for MAGI1 Gene

Previous HGNC Symbols for MAGI1 Gene

  • BAIAP1

Previous GeneCards Identifiers for MAGI1 Gene

  • GC06M154757
  • GC06M154818

Summaries for MAGI1 Gene

Entrez Gene Summary for MAGI1 Gene

  • The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGI1 Gene

MAGI1 (Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Cytoskeletal Signaling. GO annotations related to this gene include protein C-terminus binding and alpha-actinin binding. An important paralog of this gene is MAGI3.

UniProtKB/Swiss-Prot for MAGI1 Gene

  • May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).

Gene Wiki entry for MAGI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGI1 Gene

Genomics for MAGI1 Gene

Regulatory Elements for MAGI1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAGI1 Gene

65,353,525 bp from pter
66,038,836 bp from pter
685,312 bases
Minus strand

Genomic View for MAGI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGI1 Gene

Proteins for MAGI1 Gene

  • Protein details for MAGI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K188
    • O00309
    • O43863
    • O75085
    • Q96QZ8
    • Q96QZ9

    Protein attributes for MAGI1 Gene

    1491 amino acids
    Molecular mass:
    164581 Da
    Quaternary structure:
    • Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4. Interacts with cytoplasmic domain of BAI1. Interacts via its WW domains with DRPLA. Interacts with ESAM, LRP2 and CXADR. May interact with CTNNB1. Interacts through its PDZ 1 domain with NET1 (By similarity). Interacts with ASIC3 and AMOT. Interacts with FCHSD2. Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex (By similarity). Interacts with DDN. Isoform 3 (via PDZ domain) interacts with RAPGEF2.

    Three dimensional structures from OCA and Proteopedia for MAGI1 Gene

    Alternative splice isoforms for MAGI1 Gene

neXtProt entry for MAGI1 Gene

Proteomics data for MAGI1 Gene at MOPED

Post-translational modifications for MAGI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGI1 Gene

Domains for MAGI1 Gene

Suggested Antigen Peptide Sequences for MAGI1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96QZ7
  • Contains 1 guanylate kinase-like domain.
  • Contains 6 PDZ (DHR) domains.
  • Contains 2 WW domains.
genes like me logo Genes that share domains with MAGI1: view

No data available for Gene Families for MAGI1 Gene

Function for MAGI1 Gene

Molecular function for MAGI1 Gene

UniProtKB/Swiss-Prot Function: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).

Gene Ontology (GO) - Molecular Function for MAGI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11168587
GO:0005524 ATP binding IEA --
GO:0008022 protein C-terminus binding TAS 9647739
GO:0032947 protein complex scaffold IEA --
GO:0051393 alpha-actinin binding IPI 16464232
genes like me logo Genes that share ontologies with MAGI1: view

Animal Model Products

CRISPR Products

miRNA for MAGI1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGI1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAGI1 Gene

Localization for MAGI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGI1 Gene

Cell junction, tight junction. Cell membrane; Peripheral membrane protein. Note=Localizes to epithelial cells tight junctions.

Subcellular locations from

Jensen Localization Image for MAGI1 Gene COMPARTMENTS Subcellular localization image for MAGI1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MAGI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 16464232
GO:0005886 plasma membrane IEA --
GO:0005911 cell-cell junction TAS 9647739
genes like me logo Genes that share ontologies with MAGI1: view

Pathways for MAGI1 Gene

genes like me logo Genes that share pathways with MAGI1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MAGI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly NAS 9647739
GO:0007155 cell adhesion TAS 9647739
GO:0007166 cell surface receptor signaling pathway TAS 9647739
GO:0070997 neuron death IMP 22166940
genes like me logo Genes that share ontologies with MAGI1: view

Compounds for MAGI1 Gene

(1) Novoseek inferred chemical compound relationships for MAGI1 Gene

Compound -log(P) Hits PubMed IDs
guanylate 76.6 13
genes like me logo Genes that share compounds with MAGI1: view

Transcripts for MAGI1 Gene

Unigene Clusters for MAGI1 Gene

Membrane associated guanylate kinase, WW and PDZ domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGI1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MAGI1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGI1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -

Relevant External Links for MAGI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGI1 Gene

mRNA expression in normal human tissues for MAGI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGI1 Gene

SOURCE GeneReport for Unigene cluster for MAGI1 Gene Hs.476636

mRNA Expression by UniProt/SwissProt for MAGI1 Gene

Tissue specificity: Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain.
genes like me logo Genes that share expressions with MAGI1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAGI1 Gene

Orthologs for MAGI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAGI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAGI1 35
  • 99.7 (n)
  • 99.73 (a)
MAGI1 36
  • 99 (a)
(Bos Taurus)
Mammalia MAGI1 35
  • 91.89 (n)
  • 95.8 (a)
MAGI1 36
  • 93 (a)
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
-- 36
  • 97 (a)
MAGI1 35
  • 89.04 (n)
  • 90.83 (a)
(Mus musculus)
Mammalia Magi1 35
  • 89.44 (n)
  • 94.04 (a)
Magi1 16
Magi1 36
  • 92 (a)
(Monodelphis domestica)
Mammalia MAGI1 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia MAGI1 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Magi1 35
  • 90.57 (n)
  • 95.08 (a)
(Gallus gallus)
Aves MAGI1 35
  • 80.81 (n)
  • 87.18 (a)
MAGI1 36
  • 84 (a)
(Anolis carolinensis)
Reptilia MAGI1 36
  • 84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19209 35
(Danio rerio)
Actinopterygii magi1a 36
  • 58 (a)
magi1b 35
  • 72.34 (n)
  • 78.08 (a)
magi1b 36
  • 72 (a)
wufj98f08 35
fruit fly
(Drosophila melanogaster)
Insecta Magi 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea magi-1 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for MAGI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAGI1 Gene

Gene Tree for MAGI1 (if available)
Gene Tree for MAGI1 (if available)

Paralogs for MAGI1 Gene

Paralogs for MAGI1 Gene

Selected SIMAP similar genes for MAGI1 Gene using alignment to 5 proteins: Pseudogenes for MAGI1 Gene

genes like me logo Genes that share paralogs with MAGI1: view

Variants for MAGI1 Gene

Sequence variations from dbSNP and Humsavar for MAGI1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs166431 -- 65,778,471(+) AAATG(C/T)AGGAA intron-variant
rs169059 -- 65,794,689(+) CTCCA(A/C)CCTGC intron-variant
rs174640 -- 65,759,024(+) ATTTT(C/T)TTTAC intron-variant
rs183811 -- 65,812,809(+) GGGTT(C/G)AAGCG intron-variant
rs190534 -- 65,758,998(+) GCTTT(C/T)TCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGI1 Gene

Variant ID Type Subtype PubMed ID
nsv876902 CNV Loss 21882294
esv2661867 CNV Deletion 23128226
nsv526343 CNV Loss 19592680
nsv460696 CNV Loss 19166990
esv2725361 CNV Deletion 23290073
esv2725364 CNV Deletion 23290073
nsv526223 CNV Loss 19592680
nsv3856 CNV Insertion 18451855
esv992084 CNV Insertion 20482838
esv1335536 CNV Insertion 17803354
nsv876903 CNV Gain 21882294
dgv5155n71 CNV Loss 21882294
nsv3857 CNV Insertion 18451855
nsv876906 CNV Loss 21882294
esv29286 CNV Loss 19812545
esv2562385 CNV Insertion 19546169
nsv507099 CNV Insertion 20534489
nsv460697 CNV Loss 19166990
nsv507100 CNV Insertion 20534489
esv2302597 CNV Deletion 18987734
esv2725365 CNV Deletion 23290073
nsv3858 CNV Loss 18451855
esv2202487 CNV Deletion 18987734
esv2725366 CNV Deletion 23290073
dgv5157n71 CNV Gain 21882294
esv2663523 CNV Deletion 23128226
nsv522932 CNV Loss 19592680

Relevant External Links for MAGI1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGI1 Gene

Disorders for MAGI1 Gene

(1) Novoseek inferred disease relationships for MAGI1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 2

Relevant External Links for MAGI1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MAGI1: view

No data available for UniProtKB/Swiss-Prot for MAGI1 Gene

Publications for MAGI1 Gene

  1. Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. (PMID: 9647739) Shiratsuchi T. … Tokino T. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. MAGI-1: a widely expressed, alternatively spliced tight junction protein. (PMID: 11969287) Laura R.P. … Lasky L.A. (Exp. Cell Res. 2002) 3 4 23
  3. Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions. (PMID: 11168587) Mino A. … Takai Y. (Genes Cells 2000) 3 4 23
  4. JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1. (PMID: 12773569) Hirabayashi S. … Hata Y. (Mol. Cell. Biol. 2003) 3 4 23
  5. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PMID: 9169421) Pirozzi G. … Fowlkes D.M. (J. Biol. Chem. 1997) 3 4

Products for MAGI1 Gene

  • Addgene plasmids for MAGI1

Sources for MAGI1 Gene

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