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MAGI1 Gene

protein-coding   GIFtS: 61
GCID: GC03M065318

Membrane Associated Guanylate Kinase, WW And PDZ Domain...

(Previous name: BAI1-associated protein 1)
(Previous symbol: BAIAP1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing
11 2
     AIP-32 3
BAIAP11 2 3 5     AIP32 3
BAI1-Associated Protein 11 2 3     BAP-12 3
TNRC192 3 5     BAP12 3
WWP32 3 5     MAGI-12 3
Atrophin-1-Interacting Protein 32 3     WW Domain-Containing Protein 32 3
Membrane-Associated Guanylate Kinase Inverted 12 3     Magi1d2
Trinucleotide Repeat-Containing Gene 19 Protein2 3     Membrane-Associated Guanylate Kinase, WW And PDZ Domain-Containing Protein
12

External Ids:    HGNC: 9461   Entrez Gene: 92232   Ensembl: ENSG000001512767   OMIM: 6026255   UniProtKB: Q96QZ73   

Export aliases for MAGI1 gene to outside databases

Previous GC identifers: GC06M154757 GC06M154818


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAGI1 Gene:
The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family.
MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane
at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell
junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. (provided
by RefSeq, Jul 2008)

GeneCards Summary for MAGI1 Gene:
MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1) is a protein-coding gene. Diseases associated with MAGI1 include avian influenza, and influenza. GO annotations related to this gene include alpha-actinin binding and protein C-terminus binding. An important paralog of this gene is MAGI2.

UniProtKB/Swiss-Prot: MAGI1_HUMAN, Q96QZ7
Function: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents
by modulating its expression at the cell surface (By similarity)

Gene Wiki entry for MAGI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAGI1 gene promoter:
         STAT1   STAT1beta   NF-kappaB   STAT1alpha   GATA-1   c-Rel   STAT2   NF-kappaB2   TGIF   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGI1 promoter sequence
   Search Chromatin IP Primers for MAGI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.1   Ensembl cytogenetic band:  3p14.1   HGNC cytogenetic band: 3p14.1

MAGI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGI1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M065318:  view genomic region     (about GC identifiers)

Start:
65,339,200 bp from pter      End:
66,024,509 bp from pter
Size:
685,310 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MAGI1_HUMAN, Q96QZ7 (See protein sequence)
Recommended Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1  
Size: 1491 amino acids; 164581 Da
Subunit: Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4. Interacts with
cytoplasmic domain of BAI1. Interacts via its WW domains with DRPLA. Interacts with ESAM, LRP2 and CXADR. May
interact with CTNNB1. Interacts through its PDZ 1 domain with NET1 (By similarity). Interacts with ASIC3 and
AMOT. Interacts with FCHSD2. Interacts with IGSF5/JAM4 and through its PDZ 2 and 3 domains with NPHS1 forming a
tripartite complex (By similarity). Interacts with DDN. Isoform 3 (via PDZ domain) interacts with RAPGEF2
Selected PDB 3D structures from and Proteopedia for MAGI1 (see all 8):
2KPK (3D)        2KPL (3D)        2Q9V (3D)        2R4H (3D)        2YSD (3D)        2YSE (3D)    
Secondary accessions: O00309 O43863 O75085 Q96QZ8 Q96QZ9
Alternative splicing: 7 isoforms:  Q96QZ7-1   Q96QZ7-2   Q96QZ7-3   Q96QZ7-4   Q96QZ7-5   Q96QZ7-6   Q96QZ7-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAGI1: NX_Q96QZ7

Explore proteomics data for MAGI1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAGI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001028229.1  NP_004733.2  NP_056335.1  

    ENSEMBL proteins: 
     ENSP00000331157   ENSP00000385450   ENSP00000418177   ENSP00000420323   ENSP00000418862  
     ENSP00000424369   ENSP00000420796   ENSP00000418044  

    MAGI1 Human Recombinant Protein Products:

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    Novus Biologicals MAGI1 Protein
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    Cloud-Clone Corp. Proteins for MAGI1

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    LSBio Antibodies in human, mouse, rat for MAGI1

    MAGI1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for MAGI1
    Cloud-Clone Corp. CLIAs for MAGI1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR008144 Guanylate_kin-like
     IPR008145 GK/Ca_channel_bsu
     IPR027417 P-loop_NTPase
     IPR001478 PDZ
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q96QZ7

    ProtoNet protein and cluster: Q96QZ7

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: MAGI1_HUMAN, Q96QZ7
    Similarity: Contains 1 guanylate kinase-like domain
    Similarity: Contains 6 PDZ (DHR) domains
    Similarity: Contains 2 WW domains


    MAGI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAGI1_HUMAN, Q96QZ7
    Function: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents
    by modulating its expression at the cell surface (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11168587
    GO:0005524ATP binding IEA--
    GO:0008022protein C-terminus binding TAS9647739
    GO:0051393alpha-actinin binding IPI16464232
         
    MAGI1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Magi1 (no phenotypes)

    MAGI1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAGI1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAGI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAGI1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAGI1

    miRNA
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    miRTarBase miRNAs that target MAGI1:
    hsa-mir-335-5p (MIRT017415), hsa-mir-24-3p (MIRT030459), hsa-mir-34a-5p (MIRT025370), hsa-mir-324-3p (MIRT042831)

    Block miRNA regulation of human, mouse, rat MAGI1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAGI1 (see all 67):
    hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-361-5p hsa-miR-300 hsa-miR-188-5p hsa-miR-130b hsa-miR-2113 hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAGI1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAGI1
    Predesigned siRNA for gene silencing in human, mouse, rat MAGI1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MAGI1 (see all 20)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAGI1 (NM_015520)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGI1

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    GenScript Custom overexpressing Cell Line Services for MAGI1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAGI1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAGI1_HUMAN, Q96QZ7: Cell junction, tight junction. Cell membrane; Peripheral membrane protein. Note=Localizes to
    epithelial cells tight junctions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA16464232
    GO:0005886plasma membrane IEA--
    GO:0005911cell-cell junction TAS9647739

    MAGI1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAGI1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Ras signaling pathway
    Rap1 signaling pathway0.36
    2Tight junction
    Tight junction
    3G protein signaling Rap1A regulation pathway
    G protein signaling Rap1A regulation pathway
    4G protein signaling H RAS regulation pathway
    G protein signaling H RAS regulation pathway
    5Cell adhesion Endothelial cell contacts by non junctional mechanisms
    Cell adhesion Endothelial cell contacts by non junctional mechanisms

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MAGI1
        Epithelial Tight Junctions

    4 GeneGo (Thomson Reuters) Pathways for MAGI1
        G-protein signaling H-RAS regulation pathway
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    G-protein signaling Rap1A regulation pathway
    Cell adhesion Endothelial cell contacts by junctional mechanisms


    2 Kegg Pathways  (Kegg details for MAGI1):
        Rap1 signaling pathway
    Tight junction


    MAGI1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MAGI1: 
              Tight Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAGI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAGI1 (Q96QZ71, 2, 3 ENSP000003854504) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FCHSD2O948681, 3, ENSP000003867224EBI-924464,EBI-1215612 I2D: score=2 STRING: ENSP00000386722
    SFNP319472, 3MINT-3974930 I2D: score=2 
    ASIC3Q9UHC33, ENSP000002975124I2D: score=4 STRING: ENSP00000297512
    ACTN4O437073, ENSP000002526994I2D: score=3 STRING: ENSP00000252699
    NET1Q7Z6283, ENSP000003471344I2D: score=3 STRING: ENSP00000347134
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly NAS9647739
    GO:0007155cell adhesion TAS9647739
    GO:0007166cell surface receptor signaling pathway TAS9647739
    GO:0070997neuron death IMP--

    MAGI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAGI1

    1 Novoseek inferred chemical compound relationship for MAGI1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 76.6 14 11168587 (2), 10618722 (2), 18971469 (1), 16177990 (1) (see all 11)



    MAGI1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAGI1 gene (3 alternative transcripts): 
    NM_001033057.1  NM_004742.2  NM_015520.1  

    Unigene Cluster for MAGI1:

    Membrane associated guanylate kinase, WW and PDZ domain containing 1
    Hs.476636  [show with all ESTs]
    Unigene Representative Sequence: NM_015520
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330909(uc003dmm.3) ENST00000402939(uc003dmn.3) ENST00000463103
    ENST00000483466(uc003dmo.3 uc003dmp.3) ENST00000460329 ENST00000497477
    ENST00000472257 ENST00000480729 ENST00000468159(uc010hnx.1) ENST00000470990(uc010hny.2)
    ENST00000494271 ENST00000479287 ENST00000464060(uc021xac.1 uc003dmr.3)
    ENST00000476703 ENST00000476403 ENST00000496734
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAGI1 (see all 67):
    hsa-miR-3678-3p hsa-miR-323-3p hsa-miR-361-5p hsa-miR-300 hsa-miR-188-5p hsa-miR-130b hsa-miR-2113 hsa-miR-3688-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAGI1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MAGI1
    Predesigned siRNA for gene silencing in human, mouse, rat MAGI1
    Clone
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    OriGene clones in human, mouse for MAGI1 (see all 20)
    OriGene ORF clones in mouse, rat for MAGI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAGI1 (NM_015520)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGI1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAGI1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAGI1
      QuantiTect SYBR Green Assays in human, mouse, rat MAGI1
      QuantiFast Probe-based Assays in human, mouse, rat MAGI1

    Additional mRNA sequence: 

    AB010894.1 AF088016.1 AF401654.1 AF401655.1 AF401656.1 AK022064.1 AK023358.1 AK056866.1 
    AK127518.1 AK289803.1 AK307794.1 AK310365.1 AL050129.1 AL050184.1 AL831897.1 AY358705.1 
    BC062367.1 BX648886.1 U80754.1 U96115.1 XR_110023.1 XR_112486.1 XR_132712.1 XR_133343.1 
    XR_171387.1 XR_171388.1 

    Selected DOTS entries (see all 41):

    DT.101959433  DT.100773907  DT.445868  DT.40126664  DT.40192152  DT.91913972  DT.97812711  DT.75149176 
    DT.97777599  DT.306704  DT.408920  DT.429962  DT.438400  DT.95128777  DT.101978301  DT.91808933 
    DT.100725658  DT.40207108  DT.40293603  DT.91754370  DT.91837245  DT.99959483  DT.40124425  DT.95234561 

    Selected AceView cDNA sequences (see all 187):

    AI985308 AL050184 AF401654 NM_004742 CA436947 BE646018 AF401656 AK124433 
    BM717629 BM848545 AW136937 BU556664 CA393929 BX282162 AL044443 U80754 
    AK130632 AI052089 AA385767 AI424867 BQ576182 BM789196 CB216524 AF401655 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MAGI1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:        -     -     -                                   -                                       
    SP2:                                                                                                
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for MAGI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAGI1 expression in normal human tissues (normalized intensities)      MAGI1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATGTATG
    MAGI1 Expression
    About this image


    MAGI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MAGI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAGI1 Protein Expression

    Genevestigator expression for MAGI1

    SOURCE GeneReport for Unigene cluster: Hs.476636

    UniProtKB/Swiss-Prot: MAGI1_HUMAN, Q96QZ7
    Tissue specificity: Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are
    highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and
    heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain

        Pathway & Disease-focused RT2 Profiler PCR Array including MAGI1: 
              Tight Junctions in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAGI1
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    QuantiFast Probe-based Assays in human, mouse, rat MAGI1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAGI1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Magi11 , 5 membrane associated guanylate kinase, WW and PDZ domain more1, 5 89.44(n)1
    94.04(a)1
      6 (42.70 cM)5
    149241  NM_001029850.41  NP_001025021.11 
     936754555 
    chicken
    (Gallus gallus)
    Aves MAGI11 membrane associated guanylate kinase, WW and PDZ domain more 80.81(n)
    87.18(a)
      416083  XM_003642021.2  XP_003642069.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAGI16
    membrane associated guanylate kinase, WW and PDZ d...
    84(a)
    1 ↔ 1
    GL343210.1(486563-628989)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.192092 Xenopus laevis transcribed sequence with weak similarity more 82.55(n)    CA790764.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj98f082 Transcribed sequence with moderate similarity to protein more 75.91(n)    AL927483.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Magi6
    Magi
    30(a)
    1 → many
    2R(17016968-17030067)
    worm
    (Caenorhabditis elegans)
    Secernentea magi-16
    Protein MAGI-1, isoform c (magi-1) mRNA, complete ...
    33(a)
    1 → many
    IV(11715090-11729281) WBGene00010444


    ENSEMBL Gene Tree for MAGI1 (if available)
    TreeFam Gene Tree for MAGI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAGI1 gene
    MAGI22  SAV12  MAGIX2  MAGI32  
    10 SIMAP similar genes for MAGI1 using alignment to 5 protein entries:     MAGI1_HUMAN (see all proteins):
    ARHGAP23    MAGI2    LIN7C    SCRIB    DLG4    PDLIM7
    MAGIX    SYNJ2BP    WWC2    MAGI3

    MAGI1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MAGI1
    PGOHUM00000235503


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAGI1 (see all 13832)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1458001091,2
    --65291020(+) AAACTA/GTATCT 2 -- ds50010--------
    rs1870839451,2
    --65291024(+) TATATA/CTTTCT 2 -- ds50010--------
    rs1389131671,2
    --65291032(+) TCTGCA/GTAATG 2 -- ds50010--------
    rs1413654631,2
    --65291207(+) AACTTC/GAGGAT 2 -- ds50010--------
    rs1507642341,2
    --65291268(+) ATTGAA/GAGCAT 2 -- ds50010--------
    rs1921981281,2
    --65291271(+) GAGAGC/TATCAG 2 -- ds50010--------
    rs1380367321,2
    --65291421(+) ACTACA/GGCTCA 2 -- ut310--------
    rs1495207501,2
    --65291437(+) TGCTTG/TGTATG 2 -- ut310--------
    rs1460905451,2
    C--65291470(+) GCATTC/TACAGA 2 -- ut310--------
    rs1400915431,2
    --65291508(+) GTATAC/TTGTGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MAGI1 (65339200 - 65589200 bp, first 250kb of MAGI1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAGI1 (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2302597CNV Deletion18987734
    esv2661867CNV Deletion23128226
    esv2725361CNV Deletion23290073
    esv2663523CNV Deletion23128226
    esv2725364CNV Deletion23290073
    esv2202487CNV Deletion18987734
    esv2725365CNV Deletion23290073
    esv2725366CNV Deletion23290073
    nsv507100CNV Insertion20534489
    nsv507099CNV Insertion20534489

    Human Gene Mutation Database (HGMD): MAGI1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAGI1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602625    OMIM disorders: --

    6 diseases for MAGI1:    About MalaCards
    avian influenza    influenza    b-cell lymphomas    schizophrenia
    hepatocellular carcinoma    endotheliitis


    MAGI1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MAGI1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 10618722 (1), 17267502 (1)

    Genetic Association Database (GAD): MAGI1
    Human Genome Epidemiology (HuGE) Navigator: MAGI1 (5 documents)

    Export disorders for MAGI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAGI1 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with MAGI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. (PubMed id 9647739)1, 2, 3, 9 Shiratsuchi T....Tokino T. (Biochem. Biophys. Res. Commun. 1998)
    2. JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1. (PubMed id 12773569)1, 2, 9 Hirabayashi S.... Hata Y. (Mol. Cell. Biol. 2003)
    3. MAGI-1: a widely expressed, alternatively spliced tight junction protein. (PubMed id 11969287)1, 2, 9 Laura R.P.... Lasky L.A. (Exp. Cell Res. 2002)
    4. Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions. (PubMed id 11168587)1, 2, 9 Mino A....Takai Y. (amp 2000)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    7. Angiomotin regulates endothelial cell-cell junctions and cell motility. (PubMed id 16043488)1, 2 Bratt A....Holmgren L. (J. Biol. Chem. 2005)
    8. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. (PubMed id 15317815)1, 2 Hruska-Hageman A.M....Welsh M.J. (J. Biol. Chem. 2004)
    9. Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains. (PubMed id 14627983)1, 2 Ohno H.... Hata Y. (Oncogene 2003)
    10. Interaction of two actin-binding proteins, synaptopodin and alpha- actinin-4, with the tight junction protein MAGI-1. (PubMed id 12042308)1, 2 Patrie K.M.... Margolis B. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9223 HGNC: 946 AceView: BAIAP1 Ensembl:ENSG00000151276 euGenes: HUgn9223
    ECgene: MAGI1 Kegg: 9223 H-InvDB: MAGI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAGI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAGI1 gene:
    Search GeneIP for patents involving MAGI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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