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MAGI1 Gene

protein-coding GIFtS: 59

GC03M065318

membrane associated guanylate kinase, WW and PDZ domain containing 1
(Previous name: BAI1-associated protein 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: BAIAP1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AIP3 ^¹, ², ³
BAIAP1 ^², ³, ⁵
BAP-1 ^³
BAP1 ^¹, ², ³
MAGI-1 ^¹, ², ³
TNRC19 ^¹, ², ³, ⁵
WWP3 ^¹, ², ³, ⁵

Descriptions
Atrophin-1-interacting protein 3 ^³
BAI1-associated protein 1 ^¹, ², ³
Membrane-associated guanylate kinase inverted 1 ^³
Trinucleotide repeat-containing gene 19 protein ^³
WW domain-containing protein 3 ^², ³
atrophin-1 interacting protein 3 ^²
membrane associated guanylate kinase inverted-1 ^²
membrane associated guanylate kinase, WW and PDZ domain containing 1 ^²
trinucleotide repeat-containing gene 19 ^²

External Ids
HGNC: 946¹
Entrez Gene: 9223²
UniProtKB: Q96QZ7³
Ensembl: ENSG00000153721⁷

Search outside databases for aliases for MAGI1 gene

Previous GC identifers: GC06M154757 GC06M154818

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for MAGI1:

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue

(MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner

surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play

a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants

encoding different isoforms have been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: MAGI1_HUMAN, Q96QZ7

Function: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced

ACCN3 currents by modulating its expression at the cell surface (By similarity)

Gene Wiki entry for MAGI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAGI1 gene

Entrez Gene cytogenetic band: 3p14.1 Ensembl cytogenetic band: 6q25.2 HGNC cytogenetic band: 3p14.1

MAGI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M065318: (about GC identifiers)

Start:	65,314,946 bp from pter
End:	65,999,549 bp from pter
Size:	684,604 bases
Orientation:	minus strand

1 alternative location:

Chr6- 154,768,003-154,873,445

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MAGI1_HUMAN, Q96QZ7 (See protein sequence)

Recommended Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Size: 1491 amino acids; 164641 Da

Subunit: Interacts through its WW 2 domain with SYNPO and through its PDZ 5 domain with ACTN4.

Interacts with cytoplasmic domain of BAI1. Interacts via its WW domains with DRPLA. Interacts with

ESAM, LRP2 and CXADR. May interact with CTNNB1. Interacts through its PDZ 1 domain with NET1 (By

similarity). Interacts with ACCN3 and AMOT. Interacts with FCHSD2. Interacts with IGSF5/JAM4 and

through its PDZ 2 and 3 domains with NPHS1 forming a tripartite complex (By similarity). Interacts

with DDN

Subcellular location: Cell junction, tight junction. Cell membrane; Peripheral membrane protein.

Note=Localizes to epithelial cells tight junctions

PDB structures from and Proteopedia :

2Q9V (3D)

2R4H (3D)

2YSD (3D)

2YSE (3D)

2ZAJ (3D)

3BPU (3D)

Secondary accessions: O00309 O43863 O75085 Q96QZ8 Q96QZ9

Alternative splicing: 7 isoforms: Q96QZ7-1 Q96QZ7-2 Q96QZ7-3 Q96QZ7-4 Q96QZ7-5 Q96QZ7-6 Q96QZ7-7 (Additional isoforms seem to exist)

Post-translational modifications:

Phosphorylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001028229.1 NP_004733.2 NP_056335.1

ENSEMBL proteins:

ENSP00000356182 ENSP00000356178 ENSP00000356173

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MAGI1)
	Human Recombinant Proteins from Abnova (MAGI1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	9647739
GO:0005911	cell-cell junction	TAS	9647739
GO:0005923	tight junction	IEA	--

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Antibodies for MAGI1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for MAGI1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MAGI1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAGI1)
	Novus Biologicals Antibodies for MAGI1

Assays for MAGI1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q96QZ7

ProtoNet protein and cluster: Q96QZ7

1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain

UniProtKB/Swiss-Prot: MAGI1_HUMAN, Q96QZ7

Similarity: Contains 1 guanylate kinase-like domain

Similarity: Contains 6 PDZ (DHR) domains

Similarity: Contains 2 WW domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGI1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAGI1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004742

Applied Biosystems Silencer® siRNAs for MAGI1

Sigma-Aldrich siRNA and siRNA Panels for MAGI1

Sigma-Aldrich shRNA Panels and shRNA for MAGI1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001033057
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001033057
untagged cDNA clones in CMV expression vector (see all 3): NM_001033057

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001033057

UniProtKB/Swiss-Prot: MAGI1_HUMAN, Q96QZ7

Function: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced

ACCN3 currents by modulating its expression at the cell surface (By similarity)

2 MGI phenotypic alleles for Magi1 (no phenotypes)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0008022	protein C-terminus binding	TAS	9647739

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for MAGI1 (Your Favorite Gene powered by Ingenuity)

PTEN Signaling

GeneDecks MAGI1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for MAGI1

5/12 Interacting proteins for MAGI1 (Q96QZ7^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 12 )
Interactant Interaction Details
GeneCard External ID(s)
ADRB1 P08588¹ EBI-924464, EBI-991009
FCHSD2 O94868¹ EBI-924464, EBI-1215612
BZW1 Q9BUY0¹ EBI-924464, EBI-1046727
SFN P31947² MINT-3974930
-- P06428² MINT-74910
-- P17386² MINT-74905
-- P06463² MINT-6628204 MINT-6628216 MINT-69620 MINT-69618 MINT-74901
-- P04019² MINT-74909
-- P06931² MINT-74913
-- P03127² MINT-74914
-- P06462² MINT-74906
-- P03126² MINT-74902 MINT-69622
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3 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly NAS 9647739
GO:0007155 cell adhesion TAS 9647739
GO:0007166 cell surface receptor linked signal transduction TAS 9647739
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGI1
1 Novoseek chemical compound relationship for MAGI1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
guanylate	76.54	13	11168587 (2), 10618722 (2), 18971469 (1), 12773569 (1) (see all 10)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGI1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAGI1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004742

Sigma-Aldrich siRNA and siRNA Panels for MAGI1

Sigma-Aldrich shRNA Panels and shRNA for MAGI1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001033057 NM_004742 NM_015520

REFSEQ mRNAs for MAGI1 gene (3 alternative transcripts):

NM_001033057.1 NM_004742.2 NM_015520.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001033057 NM_004742 NM_015520

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001033057
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001033057
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001033057

Additional cDNA sequence:

AB010894.1 AF088016.1 AF401654.1 AF401655.1 AF401656.1 AK023358.1 AK127518.1 AK289803.1

AK307794.1 AK310365.1 AL050184.1 BC062367.1 U80754.1 U96115.1

15 DOTS entries:

DT.101959433 DT.100773907 DT.445868 DT.40126664 DT.40192152 DT.75149176 DT.97777599 DT.40207108

DT.40293603 DT.100725658 DT.91837245 DT.99959483 DT.40237242 DT.95304665 DT.95151745

24/187 AceView cDNA sequences (see all 187 ):

BM716032 BC062367 AI276206 AW136937 AI962678 AI130725 BM843919 BM763095

AK127518 AW615204 U80754 BM479650 BM717629 AK130632 AI424867 AF401656

AF401655 AI052089 AW241675 BG426447 CB216524 AK124433 AL044443 BQ938948

highest scoring ESTs for MAGI1:

AB010894 AA099904 BM762845 BM843919 BM844027 BQ706291 BU159638 U96115 AA026617 AA026729

Unigene Cluster for MAGI1:

Membrane associated guanylate kinase, WW and PDZ domain containing 1

Hs.651939 [show with all ESTs]

Unigene Representative Sequence: NM_015520

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000367213 ENST00000367209 ENST00000367205

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MAGI1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAGI1

¹ / ² / ³

16 probe-sets matching MAGI1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32268_at²^{, 3}	U95-A	1	1.00	1.00	-0.15	0.45	AB010894	1.00	0.85	0.93	1
67248_at²^{, 3}	U95-E	1	1.00	1.00	0.21	0.50	AI580392	0.60	1.00	0.82	1
63817_at²^{, 3}	U95-C	2	1.00	0.50	0.66	1.61	AA099904	0.80	1.00	0.91	1
150_at²^{, 3}	U95-A	2	1.00	0.50	-0.10	0.57	U96115	0.80	1.00	0.91	1
83698_r_at²^{, 3}	U95-D	2	1.00	0.50	0.55	1.18	AL044443	0.60	1.00	0.82	1
32270_g_at²^{, 3}	U95-A	2	1.00	0.50	-0.04	0.37	W26805	0.60	1.00	0.82	1
81395_at²^{, 3}	U95-D	1	0.88	1.00	0.42	1.19	N47255	0.60	1.00	0.82	1
206144_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004742	0.60	1.00	0.82	1
225465_at²^{, 3}	U133-B	2	1.00	0.50	--	--	AK023358	0.60	1.00	0.82	1
232859_s_at²	U133-B	3	1.00	0.48	--	--	--	--	--	--	--
206144_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1559257_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1559256_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555262_a_at²	U133Plus2	2	1.00	0.59	--	--	--	--	--	--	--
225465_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
232859_s_at²	U133Plus2	3	1.00	0.48	--	--	--	--	--	--	--

GeneDecks MAGI1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAATGTATG

SOURCE GeneReport for Unigene cluster: Hs.651939
Expression variation in blood from EXPOLDB for MAGI1
UniProtKB/Swiss-Prot: MAGI1_HUMAN, Q96QZ7
Tissue specificity: Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2
and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is
predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in
pancreas and brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for MAGI1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CNKSR3¹	--	CNKSR family member 3	90.97(n) 93.41(a)	476565 XM_533770.2 XP_533770.2
chimpanzee (Pan troglodytes)	CNKSR3¹	--	CNKSR family member 3	99.68(n) 99.66(a)	465215 XM_520680.2 XP_520680.2
rat (Rattus norvegicus)	Magi1¹	--	membrane associated guanylate kinase, WW and PDZ domain more	90.57(n) 95.08(a)	500261 NM_001030045.1 NP_001025216.1
mouse (Mus musculus)	Magi1^{1, 5}	6⁵	membrane associated guanylate kinase, WW and PDZ domain more^{1, 5}	89.71(n)¹ 94.38(a)¹	14924¹ NM_001029850.3¹ NP_001025021.1¹ AB194411⁵ AB194412⁵ (see all 26)
zebrafish (Danio rerio)	wufj98f08²	--	Transcribed sequence with moderate similarity to protein more	75.91(n)	AL927483.1

About this table Species with no ortholog for MAGI1

ENSEMBL Gene Tree for MAGI1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for MAGI1 gene

IPCEF1² CNKSR1² CNKSR2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/4724 NCBI SNPs in MAGI1 are shown (see all 4724 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1407)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2061937^1,2	A,C,F,H	65315948(-)	`TCTAGA/GTCTGG`	2	--	ut3¹		13	MN EU EA WA NA	2640
	rs11708083^1,2	C,F,H	65320068(+)	`CAATCG/AGAACA`	3	--	ut3¹ int¹		10	EU EA WA NA	1022
	rs9826322^1,2	F,H	65321626(+)	`ACAAAC/TAAACA`	3	--	int¹ ut3¹		4	EU EA WA	414
--	rs9863699^1,2	F,H	65321526(+)	`CCTCAA/GCATAT`	3	--	int¹ ut3¹		4	EU EA WA	420
	rs9831035^1,2	H	65315121(+)	`CCATAA/CGTCAA`	2	--	ut3¹		4	EU EA WA	404
	rs3796146^1,2	H	65315816(+)	`GGCTAC/TGGCCG`	2	--	ut3¹		4	EU EA WA	406
	rs2199818^1,2	H	65321708(-)	`ATGGCC/TTAAGA`	3	--	int¹ ut3¹		4	EU EA WA	418
	rs1904533^1,2	H	65321524(-)	`ATGTTG/CAGGCA`	3	--	int¹ ut3¹		5	MN EU EA WA	604
	rs1524972^1,2	A,C,F,H,O	65485436(+)	`CTGAAT/CGATAG`	3	--	int¹		12	MN EU EA WA NA	1164
	rs970935^1,2	A,C,F,H,O	65702652(+)	`CCCGGT/AACTAG`	3	--	int¹		16	EU EA WA NA	1472

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HapMap Linkage Disequilibrium images for MAGI1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 602625

1 Novoseek disease relationship for MAGI1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0.00	2	10618722 (1), 17267502 (1)

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Human Genome Epidemiology Navigator: MAGI1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/41 PubMed articles for MAGI1 gene (see all 41 ):

Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. (PubMed id 9647739)^{1, 2, 3, 4} Shiratsuchi T....Tokino T. (1998)
MAGI-1: a widely expressed, alternatively spliced tight junction protein. (PubMed id 11969287)^{1, 3, 4} Laura R.P.... Lasky L.A. (2002)
Angiomotin regulates endothelial cell-cell junctions and cell motility. (PubMed id 16043488)^{3, 4} Bratt A....Holmgren L. (2005)
PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. (PubMed id 15317815)^{3, 4} Hruska-Hageman A.M....Welsh M.J. (2004)
Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains. (PubMed id 14627983)^{3, 4} Ohno H.... Hata Y. (2003)
Interaction of two actin-binding proteins, synaptopodin and alpha- actinin-4, with the tight junction protein MAGI-1. (PubMed id 12042308)^{3, 4} Patrie K.M.... Margolis B. (2002)
Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. (PubMed id 9647693)^{3, 4} Wood J.D....Ross C.A. (1998)
cDNAs with long CAG trinucleotide repeats from human brain. (PubMed id 9225980)^{2, 3} Margolis R.L....Ross C.A. (1997)
Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)^{3, 4} Pirozzi G.... Fowlkes D.M. (1997)
Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1. (PubMed id 16019084)^{1, 3} Patrie K.M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9223	HGNC: 946	AceView: BAIAP1	Ensembl:ENSG00000153721	euGenes: HUgn9223
ECgene: MAGI1	H-InvDB: MAGI1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for MAGI1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MAGI1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAGI1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAGI1		Antibodies for MAGI1
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	Lentivirus-delivered shRNAs for MAGI1		Browse small molecules at Sigma-Aldrich
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	Antibodies (MAGI1)

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Antibodies for MAGI1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MAGI1 Gene at Home site.
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MAGI1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for MAGI1

Summaries
for MAGI1

Genomic Location
for MAGI1

Proteins
for MAGI1

Protein Domains/
Families
for MAGI1

Gene Function
for MAGI1

Pathways & Interactions
for MAGI1

Drugs & Compounds
for MAGI1

Transcripts
for MAGI1

Expression
for MAGI1

Orthologs
for MAGI1

Paralogs
for MAGI1

SNPs/Variants
for MAGI1

Disorders & Mutations
for MAGI1

Medical News
for MAGI1

Publications
for MAGI1

Search for MAGI1

Genome Databases showing MAGI1

Other Databases showing MAGI1

Specialized Databases showing MAGI1

Licensable Technologies
for MAGI1

Services
for MAGI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAGI1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor MAGI1

Summariesfor MAGI1

Genomic Locationfor MAGI1

Proteinsfor MAGI1

Protein Domains/Familiesfor MAGI1

Gene Functionfor MAGI1

Pathways & Interactionsfor MAGI1

Drugs & Compoundsfor MAGI1

Transcriptsfor MAGI1

Expression for MAGI1

Orthologsfor MAGI1

Paralogsfor MAGI1

SNPs/Variantsfor MAGI1

Disorders & Mutationsfor MAGI1

Medical Newsfor MAGI1

Publicationsfor MAGI1

Search for MAGI1

Genome Databases showing MAGI1

Other Databases showing MAGI1

Specialized Databases showing MAGI1

Licensable Technologiesfor MAGI1

Servicesfor MAGI1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAGI1

Summaries
for MAGI1

Genomic Location
for MAGI1

Proteins
for MAGI1

Protein Domains/
Families
for MAGI1

Gene Function
for MAGI1

Pathways & Interactions
for MAGI1

Drugs & Compounds
for MAGI1

Transcripts
for MAGI1

Expression
for MAGI1

Orthologs
for MAGI1

Paralogs
for MAGI1

SNPs/Variants
for MAGI1

Disorders & Mutations
for MAGI1

Medical News
for MAGI1

Publications
for MAGI1

Licensable Technologies
for MAGI1

Services
for MAGI1