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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGEL2 Gene

protein-coding   GIFtS: 46
GCID: GC15M023888

MAGE-like 2


(Previous symbol: NDNL1)
 Explore 11 diseases affiliated with
MAGEL2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAGEL2    

Aliases
for MAGEL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
MAGE-Like 21 2
NDNL11 2 3 5
NM151
Necdin-Like Protein 12 3
Protein NM152 3
MAGE-Like Protein 22

External Ids:    HGNC: 68141   Entrez Gene: 545512   Ensembl: ENSG000002545857   OMIM: 6052835   UniProtKB: Q9UJ553   

Export aliases for MAGEL2 gene to outside databases

Previous GC identifers: GC15M021024 GC15M016778 GC15M021306 GC15M021436 GC15M021439 GC15M002024


Summaries
for MAGEL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAGEL2:
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region.
Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a
gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been
implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also
localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS.
(provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: MAGL2_HUMAN, Q9UJ55
Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.
Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate
complex




Genomic Views
for MAGEL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_026446.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGEL2 gene promoter:
         GR   AP-1   AML1a   MyoD   E47   CREB   HOXA5   Hand1   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MAGEL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q11-q12   Ensembl cytogenetic band:  15q11.2   HGNC cytogenetic band: 15q11-q12

MAGEL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEL2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M023888:  view genomic region     (about GC identifiers)

Start:
 23,888,691 bp from pter      End:
 23,892,993 bp from pter
Size:
 4,303 bases      Orientation:
 minus strand

Proteins
for MAGEL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAGL2_HUMAN, Q9UJ55 (See protein sequence)
Recommended Name: MAGE-like protein 2  
Size: 529 amino acids; 58669 Da
Subunit: Interacts with TRIM27

Explore the universe of human proteins at neXtProt for MAGEL2: NX_Q9UJ55

MAGEL2 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_061939.3  
ENSEMBL proteins: 
 ENSP00000433433  

Human Recombinant Protein Products for MAGEL2: 
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Browse ProSpec Recombinant Proteins
Uscn Proteins for MAGEL2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--

MAGEL2 for ontologies           About GeneDecksing



MAGEL2 Antibody Products: 
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Assay Products for MAGEL2: 
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Uscn ELISAs and CLIAs for MAGEL2

Protein Domains /
Families
for MAGEL2 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
MAGEL2 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR002190 MAGE

Graphical View of Domain Structure for InterPro Entry Q9UJ55

ProtoNet protein and cluster: Q9UJ55

1 Blocks protein family: IPB002190 MAGE protein

UniProtKB/Swiss-Prot: MAGL2_HUMAN, Q9UJ55
Similarity: Contains 1 MAGE domain


Function
for MAGEL2 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Molecular Function:

     UniProtKB/Swiss-Prot Summary: MAGL2_HUMAN, Q9UJ55
Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.
Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate
complex

     Genatlas biochemistry entry for MAGEL2:
melanoma antigen (MAGE)-like 2,intronless located in the PWCR region,(paternally) expressed in brain,fetal and
adult,maternally imprinted

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0005515protein binding ----
     
MAGEL2 for ontologies           About GeneDecksing


Phenotypes:
     9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Magel2):
 behavior/neurological  cellular  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
 mortality/aging  nervous system  reproductive system  taste/olfaction 

MAGEL2 for phenotypes           About GeneDecksing

Animal Models:
     Mouse knock-out Magel2tm1.1Mus for MAGEL2
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MAGEL2 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAGEL2
8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate MAGEL2 (see all 11):
hsa-miR-21* hsa-miR-520d-5p hsa-miR-1271 hsa-miR-551b* hsa-miR-3133 hsa-miR-548l hsa-miR-182 hsa-miR-513b
SwitchGear 3'UTR luciferase reporter plasmid: MAGEL2 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAGEL2
OriGene shRNA RFP: MAGEL2
OriGene siRNA: MAGEL2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAGEL2
Sirion Biotech Custom design and validation of potent shRNA sequences against MAGEL2 

Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of MAGEL2 
Sirion Biotech Customized adenovirus for potent knockdown of MAGEL2

Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEL2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEL2 

Cell Line
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Sirion Biotech Customized inducible overexpressing cell line services for MAGEL2

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEL2


Pathways & Interactions
for MAGEL2 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEL2

2 Interacting proteins for MAGEL2 (Q9UJ553) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
E2F1Q010943I2D: score=1 
NGFRP081383I2D: score=1 
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-dependent ----
GO:0008150biological_process ND--

MAGEL2 for ontologies           About GeneDecksing



Drugs & Compounds
for MAGEL2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAGEL2
Search CenterWatch for drugs/clinical trials and news about MAGEL2 / MAGL2 

Transcripts
for MAGEL2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for MAGEL2 gene: 
NM_019066.4  

Unigene Cluster for MAGEL2:

MAGE-like 2
Hs.141496  [show with all ESTs]
Unigene Representative Sequence: NM_019066
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000532292(uc001ywj.4)

miRNA
Products:     		 OriGene 3'-UTR Clone: MAGEL2
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAGEL2
8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate MAGEL2 (see all 11):
hsa-miR-21* hsa-miR-520d-5p hsa-miR-1271 hsa-miR-551b* hsa-miR-3133 hsa-miR-548l hsa-miR-182 hsa-miR-513b
SwitchGear 3'UTR luciferase reporter plasmid: MAGEL2 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAGEL2
OriGene shRNA RFP: MAGEL2
OriGene siRNA: MAGEL2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAGEL2
Sirion Biotech Custom design and validation of potent shRNA sequences against MAGEL2 
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEL2 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: MAGEL2 (NM_019066)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGEL2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEL2 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEL2
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAGEL2
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEL2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEL2

Additional cDNA sequence: 

AJ243531.1 BC035839.1 BC063834.1 BC112257.1 BC112259.1 

2 DOTS entries:

DT.431115  DT.102825782 

24/32 AceView cDNA sequences (see all 32):

AL528236 BC035839 AA939255 AI702224 CR592043 AI202090 BC063834 BQ884030 
BM547670 AI129312 AI375768 AA418718 AV751488 AJ243531 BF058258 NM_019066 
BF968700 AA451737 BG914365 BM887989 BI912687 AI206611 AA027026 BX108950 

GeneLoc Exon Structure


Expression
for MAGEL2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAGEL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCATTGTA
MAGEL2 Expression
About this image

MAGEL2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
Neural TubeDiencephalonNeural Tube
Neural TubeTelencephalonNeural Tube
SomiteLumbar Vertebral BodySomite
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

Genevestigator expression for MAGEL2

SOURCE GeneReport for Unigene cluster: Hs.141496

UniProtKB/Swiss-Prot: MAGL2_HUMAN, Q9UJ55
Tissue specificity: Expressed in placenta, fetal and adult brain. Not detected in heart and small intestine, very low
levels in fibroblasts. Not expressed in brain of a Prader-Willi patient

    SABiosciences Custom PCR Arrays for MAGEL2
Primer
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEL2

Orthologs
for MAGEL2 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of animals.

Orthologs for MAGEL2 gene from 3/16 species (see all 16)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
lizard
(Anolis carolinensis)		 Reptilia --
 --
 40(a)
 1 → many
 1(205669616-205678308)
zebrafish
(Danio rerio)		 Actinopterygii ndnl26
 necdin-like 2
 40(a)
 1 → many
 23(13012414-13025121)
fruit fly
(Drosophila melanogaster)		 Insecta MAGE6
 MAGE
 24(a)
 1 → many
 3R(2979960-2980898)


ENSEMBL Gene Tree for MAGEL2 (if available)
TreeFam Gene Tree for MAGEL2 (if available) 

Paralogs
for MAGEL2 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MAGEL2 gene
MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB42  MAGEB12  MAGEC12  MAGED42  
MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGEE12  
MAGED12  MAGEA22  MAGEC32  MAGEA32  NDN2  MAGEB22  MAGEB32  MAGED4B2  
MAGEA42  MAGEE22  MAGEA12  MAGEA102  MAGEB182  MAGEA2B2  MAGEB62  TRO2  
MAGEA112  NDNL22  MAGEF12  
18/30 SIMAP similar genes for MAGEL2 using alignment to 5 protein entries:     MAGL2_HUMAN (see all proteins) (see all similar genes):
TRO    MAGEH1    MAGEA8    MAGE-B1    MAGEB1    MAGEF1
MAGEB2    MAGEB4    NDNL2    MAGEA1    MAGEA4    MAGEB3
MAGEC4    MAGEA6    MAGEA2    MAGEA2B    MAGEA3    MAGEB10

MAGEL2 for paralogs           About GeneDecksing



Genomic Variants
for MAGEL2 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/106 NCBI SNPs in MAGEL2 are shown (see all 106)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 15 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1929773011,2
--23888199(+) ATGAAA/GACTGT 1 -- ds50010--------
rs1397133241,2
--23888204(+) GACTGC/TTTTTT 1 -- ds50010--------
rs1498473351,2
--23888257(+) TTTCCA/GTCCCG 1 -- ds50010--------
rs1448547841,2
--23888262(+) ATCCCA/GGTAGC 1 -- ds50010--------
rs111613181,2
C,F,A,H--23888266(+) CGGTAG/ACAGTG 1 -- ds500128Minor allele frequency- A:0.21NS EA NA WA 3136
rs8508231,2
C,F,O,A,H--23888309(-) CGTGGG/CGGGGT 1 -- ds500114Minor allele frequency- C:0.28MN NS EA NA WA CSA 976
rs1846505481,2
--23888465(+) GGCACC/TAACGT 1 -- ds50010--------
rs1485914851,2
--23888486(+) ATTAAA/TCTCCT 1 -- ds50010--------
rs1869622911,2
--23888491(+) TCTCCC/TGGAGA 1 -- ds50010--------
rs771059131,2
F--23888581(+) ATCACC/TGTGGT 1 -- ds50011Minor allele frequency- T:0.14EA 120

HapMap Linkage Disequilibrium report for MAGEL2 (23888691 - 23892993 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MAGEL2: --

SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEL2
DNA2.0 Custom Variant and Variant Library Synthesis for MAGEL2

Disorders / Diseases
for MAGEL2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
MAGEL2 for disorders           About GeneDecksing

OMIM gene information: 605283    OMIM disorders: --

UniProtKB/Swiss-Prot: MAGL2_HUMAN, Q9UJ55
  • Note=May play a role in Prader-Willi syndrome (PWS) which is a contiguous gene syndrome resulting from
    • inactivity of the paternal copies of a number of genes on 15q11, through deletion or disruption of these genes or
    maternal uniparental disomy 15. The PWS syndrome is characterized by muscular hypotonia, mental retardation, short
    stature, obesity, hypogonadotropic hypogonadism, and small hands and feet

    11 diseases for MAGEL2:    About MalaCards
    prader-willi syndrome    hypotonia    obesity    short stature
    angelman syndrome    mood disorder    hypogonadotropism    hypogonadism
    neuronitis    schizophrenia    melanoma

    2 Novoseek disease relationships for MAGEL2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prader-willi syndrome 88.4 2 14593116 (2)
    angelman syndrome 84.7 1 14593116 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAGEL2 (1 document)

    Export disorders for MAGEL2 gene to outside databases

    Publications
    for MAGEL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGEL2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with MAGEL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human MAGEL2 gene and its mouse homologue are paternally expressed and mapped to the Prader-Willi region. (PubMed id 10556298)1, 2, 3 Boccaccio I....Muscatelli F. (1999)
    2. MAGE-RING protein complexes comprise a family of E3 u biquitin ligases. (PubMed id 20864041)1, 2 Doyle J.M....Potts P.R. (2010)
    3. Expression and imprinting of MAGEL2 suggest a role in Prader-Willi syndrome and the homologous murine imprinting phenotype. (PubMed id 10915770)1, 2 Lee S.... Wevrick R. (2000)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. Lack of association between MAGEL2 and schizophrenia and mood disorders in the Japanese population. (PubMed id 20467835)1 Fukuo Y....Iwata N. (2010)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Prader-Willi Syndrome (PubMed id 20301505)1 Driscoll D.J....Cassidy S.B. (1993)
    8. Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. (PubMed id 14593116)9 Kuwako K....Yoshikawa K. (2004)
    9. Regionally reduced brain volume, altered serotonin ne urochemistry, and abnormal behavior in mice null for the circadian rhythm outpu t gene Magel2. (PubMed id 19199291)9 Mercer R.E....Wevrick R. (2009)
    10. The Prader-Willi syndrome murine imprinting center is not involved in the spatio-temporal transcriptional regulation of the Necdin gene. (PubMed id 15634360)9 Watrin F....Muscatelli F. (2005)

    External Searches for MAGEL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MAGEL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54551 HGNC: 6814 AceView: MAGEL2 Ensembl:ENSG00000254585 euGenes: HUgn54551
    ECgene: MAGEL2 H-InvDB: MAGEL2

    Other Databases showing MAGEL2 gene

    (According to HUGE)
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    Specialized Databases showing MAGEL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAGEL2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAGEL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for MAGEL2 gene:
    Search GeneIP for patents involving MAGEL2

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