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Aliases for MAGEH1 Gene

Aliases for MAGEH1 Gene

  • Melanoma Antigen Family H1 2 3
  • Apoptosis-Related Protein 1 3 4
  • Restin 3 4
  • APR-1 3 4
  • APR1 3 4
  • Melanoma Antigen Family H, 1 3
  • MAGE-H1 Antigen 4
  • MAGEH 3

External Ids for MAGEH1 Gene

Previous GeneCards Identifiers for MAGEH1 Gene

  • GC0XP052453
  • GC0XP053416
  • GC0XP054083
  • GC0XP054445
  • GC0XP055361
  • GC0XP055495
  • GC0XP052527

Summaries for MAGEH1 Gene

Entrez Gene Summary for MAGEH1 Gene

  • This gene belongs to the non-CT (non cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. [provided by RefSeq, Aug 2013]

GeneCards Summary for MAGEH1 Gene

MAGEH1 (Melanoma Antigen Family H1) is a Protein Coding gene. Diseases associated with MAGEH1 include melanoma. Among its related pathways are p75(NTR)-mediated signaling. An important paralog of this gene is MAGEC3.

Gene Wiki entry for MAGEH1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEH1 Gene

Genomics for MAGEH1 Gene

Regulatory Elements for MAGEH1 Gene

Genomic Location for MAGEH1 Gene

Chromosome:
X
Start:
55,452,089 bp from pter
End:
55,453,568 bp from pter
Size:
1,480 bases
Orientation:
Plus strand

Genomic View for MAGEH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEH1 Gene

Proteins for MAGEH1 Gene

  • Protein details for MAGEH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H213-MAGH1_HUMAN
    Recommended name:
    Melanoma-associated antigen H1
    Protein Accession:
    Q9H213
    Secondary Accessions:
    • B2R8V9
    • Q5JRJ3
    • Q9Y5M2

    Protein attributes for MAGEH1 Gene

    Size:
    219 amino acids
    Molecular mass:
    24441 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEH1 Gene

Proteomics data for MAGEH1 Gene at MOPED

Post-translational modifications for MAGEH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MAGEH1 Gene

Domains & Families for MAGEH1 Gene

Gene Families for MAGEH1 Gene

Protein Domains for MAGEH1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H213

UniProtKB/Swiss-Prot:

MAGH1_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEH1: view

Function for MAGEH1 Gene

Gene Ontology (GO) - Molecular Function for MAGEH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEH1: view
genes like me logo Genes that share phenotypes with MAGEH1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEH1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEH1 Gene

Localization for MAGEH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEH1 Gene COMPARTMENTS Subcellular localization image for MAGEH1 gene
Compartment Confidence
cytosol 1

Gene Ontology (GO) - Cellular Components for MAGEH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MAGEH1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAGEH1 Gene

Pathways & Interactions for MAGEH1 Gene

SuperPathways for MAGEH1 Gene

Superpath Contained pathways
1 p75(NTR)-mediated signaling
genes like me logo Genes that share pathways with MAGEH1: view

Pathways by source for MAGEH1 Gene

1 BioSystems pathway for MAGEH1 Gene

Gene Ontology (GO) - Biological Process for MAGEH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 10948432
genes like me logo Genes that share ontologies with MAGEH1: view

No data available for SIGNOR curated interactions for MAGEH1 Gene

Drugs & Compounds for MAGEH1 Gene

No Compound Related Data Available

Transcripts for MAGEH1 Gene

mRNA/cDNA for MAGEH1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(166) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEH1 Gene

Melanoma antigen family H, 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEH1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEH1 Gene

No ASD Table

Relevant External Links for MAGEH1 Gene

GeneLoc Exon Structure for
MAGEH1
ECgene alternative splicing isoforms for
MAGEH1

Expression for MAGEH1 Gene

mRNA expression in normal human tissues for MAGEH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAGEH1 Gene

This gene is overexpressed in Fetal Brain (52.3) and Islet of Langerhans (16.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEH1 Gene



SOURCE GeneReport for Unigene cluster for MAGEH1 Gene Hs.279819

genes like me logo Genes that share expression patterns with MAGEH1: view

Protein tissue co-expression partners for MAGEH1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAGEH1 Gene

Orthologs for MAGEH1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAGEH1 35
  • 88.22 (n)
  • 93.43 (a)
MAGEH1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAGEH1 35
  • 87.41 (n)
  • 93.37 (a)
MAGEH1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mageh1 35
  • 88.55 (n)
  • 92.82 (a)
Mageh1 16
Mageh1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mageh1 35
  • 88.21 (n)
  • 92.31 (a)
chimpanzee
(Pan troglodytes)
Mammalia MAGEH1 36
  • 100 (a)
OneToOne
Species with no ortholog for MAGEH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEH1 Gene

ENSEMBL:
Gene Tree for MAGEH1 (if available)
TreeFam:
Gene Tree for MAGEH1 (if available)

Paralogs for MAGEH1 Gene

Paralogs for MAGEH1 Gene

genes like me logo Genes that share paralogs with MAGEH1: view

Variants for MAGEH1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MAGEH1 Gene

Variant ID Type Subtype PubMed ID
nsv435891 CNV Deletion 17901297
esv2740175 CNV Deletion 23290073
nsv469510 CNV Complex 16826518
nsv7448 OTHER Inversion 18451855

Variation tolerance for MAGEH1 Gene

Residual Variation Intolerance Score: 13.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEH1 Gene

HapMap Linkage Disequilibrium report
MAGEH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MAGEH1 Gene

Disorders for MAGEH1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEH1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association

Relevant External Links for MAGEH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEH1
genes like me logo Genes that share disorders with MAGEH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEH1 Gene

Publications for MAGEH1 Gene

  1. Identification of functional genes during Fas-mediated apoptosis using a randomly fragmented cDNA library. (PMID: 16091844) Hassan M. … Hengge U.R. (Cell. Mol. Life Sci. 2005) 23 67
  2. The p75 neurotrophin receptor interacts with multiple MAGE proteins. (PMID: 12414813) Tcherpakov M. … Fainzilber M. (J. Biol. Chem. 2002) 2 67
  3. Identification of a new MAGE gene with tumor-specific expression by representational difference analysis. (PMID: 9485030) Lucas S. … Boon T. (Cancer Res. 1998) 2 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Genome-wide association study of smoking behaviours among Bangladeshi adults. (PMID: 24665060) Argos M. … Ahsan H. (J. Med. Genet. 2014) 67

Products for MAGEH1 Gene

Sources for MAGEH1 Gene

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