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Aliases for MAGEH1 Gene

Aliases for MAGEH1 Gene

  • Melanoma Antigen Family H1 2 3
  • Apoptosis-Related Protein 1 3 4
  • Restin 3 4
  • MAGEH 3 6
  • APR-1 3 4
  • APR1 3 4
  • Melanoma-Associated Antigen H1 3
  • Melanoma Antigen Family H, 1 3
  • MAGE-H1 Antigen 4

External Ids for MAGEH1 Gene

Summaries for MAGEH1 Gene

Entrez Gene Summary for MAGEH1 Gene

  • This gene belongs to the non-CT (non cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. [provided by RefSeq, Aug 2013]

GeneCards Summary for MAGEH1 Gene

MAGEH1 (Melanoma Antigen Family H1) is a Protein Coding gene. Diseases associated with MAGEH1 include melanoma. Among its related pathways are p75(NTR)-mediated signaling. An important paralog of this gene is MAGEC3.

Gene Wiki entry for MAGEH1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEH1 Gene

Genomics for MAGEH1 Gene

Genomic Location for MAGEH1 Gene

Start:
55,452,089 bp from pter
End:
55,453,568 bp from pter
Size:
1,480 bases
Orientation:
Plus strand

Genomic View for MAGEH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEH1 Gene

Regulatory Elements for MAGEH1 Gene

Proteins for MAGEH1 Gene

  • Protein details for MAGEH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H213-MAGH1_HUMAN
    Recommended name:
    Melanoma-associated antigen H1
    Protein Accession:
    Q9H213
    Secondary Accessions:
    • B2R8V9
    • Q5JRJ3
    • Q9Y5M2

    Protein attributes for MAGEH1 Gene

    Size:
    219 amino acids
    Molecular mass:
    24441 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEH1 Gene

Proteomics data for MAGEH1 Gene at MOPED

Post-translational modifications for MAGEH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEH1 Gene

Domains for MAGEH1 Gene

Protein Domains for MAGEH1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H213

UniProtKB/Swiss-Prot:

MAGH1_HUMAN
Domain:
  • Contains 1 MAGE domain.:
    • Q9H213
genes like me logo Genes that share domains with MAGEH1: view

No data available for Gene Families for MAGEH1 Gene

Function for MAGEH1 Gene

Gene Ontology (GO) - Molecular Function for MAGEH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEH1: view

Phenotypes for MAGEH1 Gene

GenomeRNAi human phenotypes for MAGEH1:
genes like me logo Genes that share phenotypes with MAGEH1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MAGEH1 Gene

Localization for MAGEH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEH1 Gene COMPARTMENTS Subcellular localization image for MAGEH1 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MAGEH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MAGEH1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAGEH1 Gene

Pathways for MAGEH1 Gene

SuperPathways for MAGEH1 Gene

Superpath Contained pathways
1 p75(NTR)-mediated signaling
genes like me logo Genes that share pathways with MAGEH1: view

Pathways by source for MAGEH1 Gene

1 BioSystems pathway for MAGEH1 Gene

Gene Ontology (GO) - Biological Process for MAGEH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 10948432
genes like me logo Genes that share ontologies with MAGEH1: view

Transcripts for MAGEH1 Gene

mRNA/cDNA for MAGEH1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(166) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEH1 Gene

Melanoma antigen family H, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEH1 Gene

No ASD Table

Relevant External Links for MAGEH1 Gene

GeneLoc Exon Structure for
MAGEH1
ECgene alternative splicing isoforms for
MAGEH1

Expression for MAGEH1 Gene

mRNA expression in normal human tissues for MAGEH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAGEH1 Gene

SOURCE GeneReport for Unigene cluster for MAGEH1 Gene Hs.279819

genes like me logo Genes that share expressions with MAGEH1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAGEH1 Gene

Orthologs for MAGEH1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEH1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAGEH1 35
  • 88.22 (n)
  • 93.43 (a)
MAGEH1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAGEH1 35
  • 87.41 (n)
  • 93.37 (a)
MAGEH1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mageh1 35
  • 88.55 (n)
  • 92.82 (a)
Mageh1 16
Mageh1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mageh1 35
  • 88.21 (n)
  • 92.31 (a)
Species with no ortholog for MAGEH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEH1 Gene

ENSEMBL:
Gene Tree for MAGEH1 (if available)
TreeFam:
Gene Tree for MAGEH1 (if available)

Paralogs for MAGEH1 Gene

Paralogs for MAGEH1 Gene

genes like me logo Genes that share paralogs with MAGEH1: view

Variants for MAGEH1 Gene

Sequence variations from dbSNP and Humsavar for MAGEH1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2499877 -- 55,453,568(+) AGTAC(A/G)TCTTG utr-variant-3-prime
rs11545211 -- 55,452,866(+) TGGGG(A/G)CCCCG synonymous-codon, reference
rs12014852 -- 55,453,106(+) GGGTC(C/T)TAAGT utr-variant-3-prime
rs140966823 -- 55,452,728(+) AAGTT(A/G)GGAAT reference, synonymous-codon
rs142873199 -- 55,452,464(+) GAGGC(C/T)TCCGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MAGEH1 Gene

Variant ID Type Subtype PubMed ID
nsv435891 CNV Deletion 17901297
esv2740175 CNV Deletion 23290073
nsv469510 CNV Complex 16826518
nsv7448 OTHER Inversion 18451855

Relevant External Links for MAGEH1 Gene

HapMap Linkage Disequilibrium report
MAGEH1
Locus Specific Mutation Databases (LSDB)
MAGEH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEH1 Gene

Disorders for MAGEH1 Gene

(1) MalaCards Diseases for MAGEH1 Gene

Search for MAGEH1 Gene in MalaCards »
genes like me logo Genes that share disorders with MAGEH1: view

No data available for UniProtKB/Swiss-Prot for MAGEH1 Gene

Publications for MAGEH1 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  2. Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes. (PMID: 10948432) Zhu F. … Wang C.J. (BioTechniques 2000) 3 4
  3. An overview of the MAGE gene family with the identification of all human members of the family. (PMID: 11454705) Chomez P. … Lucas S. (Cancer Res. 2001) 3 4
  4. The p75 neurotrophin receptor interacts with multiple MAGE proteins. (PMID: 12414813) Tcherpakov M. … Fainzilber M. (J. Biol. Chem. 2002) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MAGEH1 Gene

Sources for MAGEH1 Gene

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