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Aliases for MAGEH1 Gene

Aliases for MAGEH1 Gene

  • MAGE Family Member H1 2 3 5
  • Apoptosis-Related Protein 1 3 4
  • Melanoma Antigen Family H1 2 3
  • Restin 3 4
  • APR-1 3 4
  • APR1 3 4
  • Melanoma-Associated Antigen H1 3
  • Melanoma Antigen Family H, 1 3
  • MAGE-H1 Antigen 4
  • MAGEH 3

External Ids for MAGEH1 Gene

Previous GeneCards Identifiers for MAGEH1 Gene

  • GC0XP052453
  • GC0XP053416
  • GC0XP054083
  • GC0XP054445
  • GC0XP055361
  • GC0XP055495
  • GC0XP052527

Summaries for MAGEH1 Gene

Entrez Gene Summary for MAGEH1 Gene

  • This gene belongs to the non-CT (non cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. [provided by RefSeq, Aug 2013]

CIViC summary for MAGEH1 Gene

GeneCards Summary for MAGEH1 Gene

MAGEH1 (MAGE Family Member H1) is a Protein Coding gene. Diseases associated with MAGEH1 include Melanoma. Among its related pathways are p75(NTR)-mediated signaling.

Gene Wiki entry for MAGEH1 Gene

Additional gene information for MAGEH1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEH1 Gene

Genomics for MAGEH1 Gene

Regulatory Elements for MAGEH1 Gene

Enhancers for MAGEH1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH055716 1 ENCODE 8.8 +265.9 265936 2 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 YY1 GTF3C2 ELK1 ZNF207 KLF8 APEX2 ENSG00000227486 MAGEH1 RRAGB
GH0XH055488 0.8 ENCODE 11 +37.2 37239 4 ZNF76 SIN3A YY1 EGR1 SCRT2 CREM SP3 SMAD5 REST TFDP1 MAGEH1 KLF8 USP51 LOC101928692
GH0XH055450 0.8 ENCODE 10.8 +0.1 115 2 PKNOX1 MXI1 MAX ZBTB40 RAD21 E2F1 ZNF316 POLR2A ETV6 MAFK MAGEH1 KLF8 PAGE3
GH0XH055866 0.7 ENCODE 9.2 +415.8 415803 2 EBF1 BATF EED ATF7 RUNX3 IKZF2 ZNF687 NR2F1 JUNB DPF2 ENSG00000227486 MAGEH1 RRAGB
GH0XH055919 0.8 ENCODE 7.7 +467.6 467648 1 PKNOX1 TBL1XR1 RB1 BMI1 BATF ATF7 ETV6 RUNX3 CREM IKZF2 MAGEH1 ENSG00000227486 LOC644924
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAGEH1 on UCSC Golden Path with GeneCards custom track

Promoters for MAGEH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246769 511 2400 PKNOX1 MXI1 MAX ZBTB40 RAD21 E2F1 ZNF316 POLR2A ETV6 RUNX3

Genomic Location for MAGEH1 Gene

Chromosome:
X
Start:
55,452,089 bp from pter
End:
55,453,568 bp from pter
Size:
1,480 bases
Orientation:
Plus strand

Genomic View for MAGEH1 Gene

Genes around MAGEH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEH1 Gene

Proteins for MAGEH1 Gene

  • Protein details for MAGEH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H213-MAGH1_HUMAN
    Recommended name:
    Melanoma-associated antigen H1
    Protein Accession:
    Q9H213
    Secondary Accessions:
    • B2R8V9
    • Q5JRJ3
    • Q9Y5M2

    Protein attributes for MAGEH1 Gene

    Size:
    219 amino acids
    Molecular mass:
    24441 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEH1 Gene

Post-translational modifications for MAGEH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEH1 Gene

Domains & Families for MAGEH1 Gene

Gene Families for MAGEH1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MAGEH1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEH1: view

No data available for UniProtKB/Swiss-Prot for MAGEH1 Gene

Function for MAGEH1 Gene

Gene Ontology (GO) - Molecular Function for MAGEH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEH1: view
genes like me logo Genes that share phenotypes with MAGEH1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAGEH1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEH1 Gene

Localization for MAGEH1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEH1 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAGEH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MAGEH1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAGEH1 Gene

Pathways & Interactions for MAGEH1 Gene

SuperPathways for MAGEH1 Gene

SuperPathway Contained pathways
1 p75(NTR)-mediated signaling
genes like me logo Genes that share pathways with MAGEH1: view

Pathways by source for MAGEH1 Gene

1 BioSystems pathway for MAGEH1 Gene

Gene Ontology (GO) - Biological Process for MAGEH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 10948432
genes like me logo Genes that share ontologies with MAGEH1: view

No data available for SIGNOR curated interactions for MAGEH1 Gene

Drugs & Compounds for MAGEH1 Gene

No Compound Related Data Available

Transcripts for MAGEH1 Gene

mRNA/cDNA for MAGEH1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(166) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEH1 Gene

Melanoma antigen family H, 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAGEH1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEH1 Gene

No ASD Table

Relevant External Links for MAGEH1 Gene

GeneLoc Exon Structure for
MAGEH1
ECgene alternative splicing isoforms for
MAGEH1

Expression for MAGEH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAGEH1 Gene

This gene is overexpressed in Fetal Brain (52.3) and Islet of Langerhans (16.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEH1 Gene



Protein tissue co-expression partners for MAGEH1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGEH1 Gene:

MAGEH1

SOURCE GeneReport for Unigene cluster for MAGEH1 Gene:

Hs.279819

Evidence on tissue expression from TISSUES for MAGEH1 Gene

  • Nervous system(4.8)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with MAGEH1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEH1 Gene

Orthologs for MAGEH1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEH1 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mageh1 33 16 34
  • 88.55 (n)
cow
(Bos Taurus)
Mammalia MAGEH1 33 34
  • 88.22 (n)
rat
(Rattus norvegicus)
Mammalia Mageh1 33
  • 88.21 (n)
dog
(Canis familiaris)
Mammalia MAGEH1 33 34
  • 87.41 (n)
Species where no ortholog for MAGEH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEH1 Gene

ENSEMBL:
Gene Tree for MAGEH1 (if available)
TreeFam:
Gene Tree for MAGEH1 (if available)

Paralogs for MAGEH1 Gene

genes like me logo Genes that share paralogs with MAGEH1: view

No data available for Paralogs for MAGEH1 Gene

Variants for MAGEH1 Gene

Sequence variations from dbSNP and Humsavar for MAGEH1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000343355 -- 55,451,666(+) ACAAT(A/G)TTATC downstream-variant-500B, upstream-variant-2KB
rs1005481725 -- 55,453,577(+) TGCGC(A/T)TTTTC downstream-variant-500B, upstream-variant-2KB
rs1005933950 -- 55,453,026(+) ATTCC(G/T)CCCCT upstream-variant-2KB, reference, missense
rs1006126666 -- 55,453,488(+) GCTGT(G/T)GTGTG upstream-variant-2KB, utr-variant-3-prime
rs1009888782 -- 55,450,444(+) ACAGC(A/T)GATGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAGEH1 Gene

Variant ID Type Subtype PubMed ID
esv2740175 CNV deletion 23290073
nsv435891 CNV deletion 17901297
nsv469510 CNV gain 16826518
nsv7448 OTHER inversion 18451855

Variation tolerance for MAGEH1 Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEH1 Gene

Disorders for MAGEH1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEH1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEH1
genes like me logo Genes that share disorders with MAGEH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEH1 Gene

Publications for MAGEH1 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The p75 neurotrophin receptor interacts with multiple MAGE proteins. (PMID: 12414813) Tcherpakov M … Fainzilber M (The Journal of biological chemistry 2002) 2 3 60
  4. An overview of the MAGE gene family with the identification of all human members of the family. (PMID: 11454705) Chomez P … Lucas S (Cancer research 2001) 3 4 60
  5. Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes. (PMID: 10948432) Zhu F … Wang CJ (BioTechniques 2000) 3 4 60

Products for MAGEH1 Gene

Sources for MAGEH1 Gene

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