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Aliases for MAGEF1 Gene

Aliases for MAGEF1 Gene

  • Melanoma Antigen Family F1 2 3
  • MAGE-F1 Antigen 4

External Ids for MAGEF1 Gene

Summaries for MAGEF1 Gene

Entrez Gene Summary for MAGEF1 Gene

  • This intronless gene encodes a member of the MAGE superfamily. It is ubiquitously expressed in normal tissues and in tumor cells. This gene includes a microsatellite repeat in the coding region. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEF1 Gene

MAGEF1 (Melanoma Antigen Family F1) is a Protein Coding gene. An important paralog of this gene is MAGED1.

UniProtKB/Swiss-Prot for MAGEF1 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEF1 Gene

Genomics for MAGEF1 Gene

Genomic Location for MAGEF1 Gene

Start:
184,710,367 bp from pter
End:
184,712,048 bp from pter
Size:
1,682 bases
Orientation:
Minus strand

Genomic View for MAGEF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEF1 Gene

Regulatory Elements for MAGEF1 Gene

Proteins for MAGEF1 Gene

  • Protein details for MAGEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAY2-MAGF1_HUMAN
    Recommended name:
    Melanoma-associated antigen F1
    Protein Accession:
    Q9HAY2
    Secondary Accessions:
    • Q9H215

    Protein attributes for MAGEF1 Gene

    Size:
    307 amino acids
    Molecular mass:
    35222 Da
    Quaternary structure:
    • Interacts with LNX1, TRIM27 and NSMCE1.

neXtProt entry for MAGEF1 Gene

Proteomics data for MAGEF1 Gene at MOPED

Post-translational modifications for MAGEF1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys251

Other Protein References for MAGEF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEF1 Gene

Domains for MAGEF1 Gene

Protein Domains for MAGEF1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

MAGF1_HUMAN
Domain:
  • Contains 1 MAGE domain.:
    • Q9HAY2
genes like me logo Genes that share domains with MAGEF1: view

No data available for Gene Families for MAGEF1 Gene

Function for MAGEF1 Gene

Molecular function for MAGEF1 Gene

UniProtKB/Swiss-Prot Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Ontology (GO) - Molecular Function for MAGEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEF1: view

miRNA for MAGEF1 Gene

miRTarBase miRNAs that target MAGEF1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAGEF1 Gene

Localization for MAGEF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEF1 Gene COMPARTMENTS Subcellular localization image for MAGEF1 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MAGEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with MAGEF1: view

Pathways for MAGEF1 Gene

SuperPathways for MAGEF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEF1 Gene

None

No data available for Pathways by source for MAGEF1 Gene

Transcripts for MAGEF1 Gene

mRNA/cDNA for MAGEF1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(316) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEF1 Gene

Melanoma antigen family F, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEF1 Gene

No ASD Table

Relevant External Links for MAGEF1 Gene

GeneLoc Exon Structure for
MAGEF1
ECgene alternative splicing isoforms for
MAGEF1

Expression for MAGEF1 Gene

mRNA expression in normal human tissues for MAGEF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAGEF1 Gene

SOURCE GeneReport for Unigene cluster for MAGEF1 Gene Hs.306123

mRNA Expression by UniProt/SwissProt for MAGEF1 Gene

Q9HAY2-MAGF1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with MAGEF1: view

Orthologs for MAGEF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAGEF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEF1 36
  • 98.7 (n)
  • 97.72 (a)
MAGEF1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAGEF1 36
  • 87.81 (n)
  • 85.91 (a)
MAGEF1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAGEF1 36
  • 88.29 (n)
  • 86.38 (a)
MAGEF1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Magef1 16
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 44 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 34 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAGE 37
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 43 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ndnl2 37
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
Species with no ortholog for MAGEF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAGEF1 Gene

ENSEMBL:
Gene Tree for MAGEF1 (if available)
TreeFam:
Gene Tree for MAGEF1 (if available)

Paralogs for MAGEF1 Gene

genes like me logo Genes that share paralogs with MAGEF1: view

Variants for MAGEF1 Gene

Sequence variations from dbSNP and Humsavar for MAGEF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs12011 -- 184,711,930(-) GCTCC(C/T)TGTAC utr-variant-5-prime
rs2889559 -- 184,709,998(+) CCTCC(A/G)TCTCC downstream-variant-500B
rs4444691 -- 184,709,999(+) CTCCG(C/T)CTCCT downstream-variant-500B
rs6770319 -- 184,711,623(+) TGCCA(A/C)GGCTT missense, reference
rs9682732 -- 184,713,071(+) tccct(C/T)ccttc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAGEF1 Gene

Variant ID Type Subtype PubMed ID
nsv829816 CNV Loss 17160897
nsv508973 CNV Insertion 20534489

Relevant External Links for MAGEF1 Gene

HapMap Linkage Disequilibrium report
MAGEF1

Disorders for MAGEF1 Gene

Relevant External Links for MAGEF1

Genetic Association Database (GAD)
MAGEF1
Human Genome Epidemiology (HuGE) Navigator
MAGEF1
genes like me logo Genes that share disorders with MAGEF1: view

No data available for UniProtKB/Swiss-Prot for MAGEF1 Gene

Publications for MAGEF1 Gene

  1. MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily. (PMID: 11313144) Stone B. … Nelson B.H. (Gene 2001) 2 3 4
  2. An overview of the MAGE gene family with the identification of all human members of the family. (PMID: 11454705) Chomez P. … Lucas S. (Cancer Res. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 49
  5. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle J.M. … Potts P.R. (Mol. Cell 2010) 3 4

Products for MAGEF1 Gene

Sources for MAGEF1 Gene

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