MAGEF1 Gene
protein-coding GIFtS: 44
GCID: GC03M184428
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|
melanoma antigen family F, 1
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Aliases
for MAGEF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family F, 11 2 | | MAGE-F1 Antigen2 3 | | Melanoma-Associated Antigen F12 |
Export aliases for MAGEF1 gene to outside databasesPrevious GC identifers: GC03M181388 GC03M185611 GC03M185830 GC03M185749 GC03M185910 GC03M181838 |
Summaries
for MAGEF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEF1:
This intronless gene encodes a member of the MAGE superfamily. It is ubiquitously expressed in normal tissues and intumor cells. This gene includes a microsatellite repeat in the coding region. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MAGF1_HUMAN, Q9HAY2Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substratecomplex
|
Genomic Views
for MAGEF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEF1 gene promoter:
GATA-3 POU3F2 GATA-2 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q13MAGEF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M184428: view genomic region
(about GC identifiers)
Start:
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184,428,155 bp from pter |
End:
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184,429,836 bp from pter |
Size:
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1,682 bases |
Orientation:
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minus strand |
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Proteins
for MAGEF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGF1_HUMAN, Q9HAY2 (See
protein sequence)Recommended Name: Melanoma-associated antigen F1 Size: 307 amino acids; 35222 Da
Subunit: Interacts with LNX1, TRIM27 and NSMCE1
Secondary accessions: Q9H215Explore the universe of human proteins at neXtProt for MAGEF1: NX_Q9HAY2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HAY2
MAGEF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071432.2
ENSEMBL proteins: ENSP00000315064
Human Recombinant Protein Products:
MAGEF1 Antibody Products:
Assay Products for MAGEF1: |
Protein
Domains /
Families
for MAGEF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEF1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9HAY2ProtoNet protein and cluster: Q9HAY2 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGF1_HUMAN, Q9HAY2Similarity: Contains 1 MAGE domain |
Function
for MAGEF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAGF1_HUMAN, Q9HAY2Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substratecomplex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEF1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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|
Pathways & Interactions
for MAGEF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for MAGEF1 (ENSP000003150644) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for MAGEF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEF1
Search CenterWatch for drugs/clinical trials and news about MAGEF1 / MAGF1
|
Transcripts
for MAGEF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEF1 gene: NM_022149.4 Unigene Cluster for MAGEF1: Melanoma antigen family F, 1 Hs.306123 [show with all ESTs]Unigene Representative Sequence: NM_0221491 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000317897(uc003fpa.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEF1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAGEF1 (NM_022149) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEF1 |
Additional cDNA sequence: AF295378.1 AF320910.1 BC010056.2 5 DOTS entries: DT.452747 DT.100763175 DT.120905120 DT.100786142 DT.95257879 24/316 AceView cDNA sequences (see all 316): BU677828 AI636328 CA413331 BQ548668 NM_022149 BM979935 BX279894 BU902884 AA410365 BM849292 AI336191 AI698878 BM661739 CR605167 AW016506 CR601957 BM781997 BM671062 AI824237 AI370700 BM671615 BF445547 CR623566 AA773748
GeneLoc Exon Structure
|
Expression
for MAGEF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCTTCATT
About this image
See MAGEF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEF1
SOURCE GeneReport for Unigene cluster: Hs.306123
UniProtKB/Swiss-Prot: MAGF1_HUMAN, Q9HAY2Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for MAGEF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MAGEF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEF1 |
Orthologs
for MAGEF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEF1 gene from 3/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
45(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
34(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
21(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEF1 (if available)
TreeFam Gene Tree for MAGEF1 (if available) |
Paralogs
for MAGEF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEF1 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGEA82 MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12
- MAGED12 MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2
- MAGEE22 MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22
- TRO2 MAGEA112 NDNL22
18/37 SIMAP similar genes for MAGEF1 using alignment to 1 protein entry: MAGF1_HUMAN(see all similar genes):MAGEE1 NDNL2 MAGEB16 MAGEB17 TRO MAGEA10
MAGEA11 MAGEB3 MAGEL2 MAGED1 MAGED4 MAGED4B
MAGEA9 MAGEA9B MAGEC2 MAGEE2 MAGEA2 MAGEA2B
MAGEF1 for paralogs About GeneDecksing
|
Genomic Variants
for MAGEF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEF1 (184428155 - 184429836 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAGEF1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEF1 |
|
Disorders
/ Diseases
for MAGEF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEF1 for disorders About GeneDecksing
OMIM gene information: 609267
OMIM disorders: --
1  disease for MAGEF1: About MalaCardsmelanoma
Human Genome Epidemiology (HuGE) Navigator: MAGEF1 (1 document)
Export disorders for MAGEF1 gene to outside databases
|
Publications
for MAGEF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEF1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with MAGEF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily. (PubMed id 11313144)1, 2, 3 Stone B....Nelson B.H. (2001)
- MAGE-RING protein complexes comprise a family of E3 u biquitin ligases. (PubMed id 20864041)1, 2 Doyle J.M....Potts P.R. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- An overview of the MAGE gene family with the identification of all human members of the family. (PubMed id 11454705)1, 2 Chomez P....Lucas S. (2001)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
|
External Searches for MAGEF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEF1 gene:
Search GeneIP for patents involving MAGEF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAGEF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAGEF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEF1 |
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 | | | MAGEF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for MAGEF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEF1 |
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