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MAGEF1 Gene

protein-coding GIFtS: 47

GC03M185910

melanoma antigen family F, 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC19617 ^²

Descriptions
MAGE-F1 antigen ^², ³
melanoma antigen family F, 1 ^²
melanoma-associated antigen F1 ^²

External Ids
HGNC: 29639¹
Entrez Gene: 64110²
UniProtKB: Q9HAY2³
Ensembl: ENSG00000177383⁷

Search outside databases for aliases for MAGEF1 gene

Previous GC identifers: GC03M181388 GC03M185611 GC03M185830 GC03M185749

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for MAGEF1:

This intronless gene encodes a member of the MAGE superfamily. It is ubiquitously expressed in

normal tissues and in tumor cells. This gene includes a microsatellite repeat in the coding

region. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAGEF1 gene

Entrez Gene cytogenetic band: 3q13 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q13

MAGEF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M185910: (about GC identifiers)

Start:	185,910,849 bp from pter
End:	185,912,530 bp from pter
Size:	1,682 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MAGF1_HUMAN, Q9HAY2 (See protein sequence)

Recommended Name: Melanoma-associated antigen F1

Size: 308 amino acids; 35309 Da

Secondary accessions: Q9H215

REFSEQ proteins: NP_071432.2

ENSEMBL proteins:

ENSP00000315064

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MAGEF1)
	Human Recombinant Proteins from Abnova (MAGEF1)

OriGene Purified Recombinant Human Protein: MAGEF1

Antibodies for MAGEF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MAGEF1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAGEF1)
	Novus Biologicals Antibody for MAGEF1

Assays for MAGEF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9HAY2

ProtoNet protein and cluster: Q9HAY2

1 Blocks protein family: IPB002190 MAGE protein

UniProtKB/Swiss-Prot: MAGF1_HUMAN, Q9HAY2

Similarity: Contains 1 MAGE domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGEF1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022149

Applied Biosystems Silencer® siRNAs for MAGEF1

Sigma-Aldrich siRNA for MAGEF1

Sigma-Aldrich shRNA for MAGEF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MAGEF1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_022149
Myc/DDK tagged cDNA clone in CMV expression vector: NM_022149
untagged cDNA clones in CMV expression vector (see all 2): NM_022149

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_022149

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGEF1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGEF1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022149

Sigma-Aldrich siRNA for MAGEF1

Sigma-Aldrich shRNA for MAGEF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_022149

REFSEQ mRNAs for MAGEF1 gene:

NM_022149.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_022149

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022149
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_022149
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_022149

Additional cDNA sequence:

AF295378.1 AF320910.1 BC010056.2 CR590592.1 CR592482.1 CR596075.1 CR597086.1 CR601957.1

CR604017.1 CR605167.1 CR605442.1 CR611656.1 CR621352.1 CR623566.1

5 DOTS entries:

DT.452747 DT.100763175 DT.120905120 DT.100786142 DT.95257879

24/316 AceView cDNA sequences (see all 316 ):

AI824237 AI597665 CR623566 CR601957 BU902884 BQ070043 CR605442 BM661739

AI263037 BM781997 CR604017 AI698878 BX279894 BM761980 BU688128 BQ548668

CR592482 BU677828 CR596075 BM849292 BP351675 AI658601 BQ953639 AA906701

highest scoring ESTs for MAGEF1:

AI889519 AA057086 AA057382 AA312097 AA370572 AA425485 AA443464 AA459871 AF295378 AF320910

Unigene Cluster for MAGEF1:

Melanoma antigen family F, 1

Hs.306123 [show with all ESTs]

Unigene Representative Sequence: NM_022149

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000317897

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MAGEF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAGEF1

¹ / ² / ³

4 probe-sets matching MAGEF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
43533_s_at²^{, 3}	U95-B	1	1.00	1.00	0.94	1.23	AI889519	1.00	1.00	1.00	1
48654_r_at²^{, 3}	U95-C	1	1.00	1.00	0.98	0.77	W28443	0.40	1.00	0.76	1
218176_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_022149	0.60	1.00	0.82	1
218176_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MAGEF1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TACCTTCATT

SOURCE GeneReport for Unigene cluster: Hs.306123
UniProtKB/Swiss-Prot: MAGF1_HUMAN, Q9HAY2
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for MAGEF1 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAGEF1¹	--	melanoma antigen family F, 1	88.27(n) 86.64(a)	488109 XM_545233.2 XP_545233.2
chimpanzee (Pan troglodytes)	MAGEF1¹	--	melanoma antigen family F, 1	99.46(n) 99.02(a)	460895 XM_516919.2 XP_516919.2
cow (Bos taurus)	MAGEF1¹	--	melanoma antigen family F, 1	88.03(n) 86.24(a)	518728 XM_596928.3 XP_596928.2
mouse (Mus musculus)	Magef1⁵	16	melanoma antigen family F, 1	--	AK018285

About this table Species with no ortholog for MAGEF1

ENSEMBL Gene Tree for MAGEF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAGEF1 gene

MAGEH1² NDNL2² MAGEE2² MAGEE1² NDN²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/44 NCBI SNPs in MAGEF1 are shown (see all 44 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 18)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9872799^1,2	A,C,F,H	185911597(+)	`CATATG/TCTGGT`	1	E/A	mis¹ ese³		9		EU EA WA NA	874
	rs10937187^1,2	A,C,F,H	185912108(-)	`CCAAAT/GCCTTG`	1	S/A	mis¹ ese³		4		EU EA NA	358
	rs12011^1,2	A,C,F	185912412(-)	`GCTCCC/TTGTAC`	1	--	ut5¹		2		MN	372
--	rs4444691^1,2	A,C	185910481(+)	`ctccgC/Tctcct`	1	--	ng5¹		0	--	--	--	--
	rs34540780^1,2	C,F	185912026(-)	`CAAGAA/GGAAGA`	1	K/R	mis¹		5		NA EU EA WA	488
	rs10212515^1,2	A,C	185910729(+)	`CTCATG/TGCACT`	1	--	ng5¹		0	--	--	--	--
--	rs2889559^1,2	C	185910480(+)	`cctccA/Gtctcc`	1	--	ng5¹		0	--	--	--	--
	rs34792132^1,2	F	185911494(-)	`TGGCCA/GGTGCA`	1	P/P	syn¹		1		NA	72
	rs34404407^1,2	F	185911959(-)	`TTCCCG/TGACAT`	1	P/P	syn¹		1		NA	62
--	rs73189844^1,2	--	185912855(+)	`TTCAGG/TGCTTT`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for MAGEF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 609267

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for MAGEF1 gene:

MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily. (PubMed id 11313144)^{2, 3, 4} Stone B....Nelson B.H. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
An overview of the MAGE gene family with the identification of all human members of the family. (PubMed id 11454705)^{3, 4} Chomez P....Lucas S. (2001)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 64110	HGNC: 29639	AceView: MAGEF1	Ensembl:ENSG00000177383	euGenes: HUgn64110
ECgene: MAGEF1	H-InvDB: MAGEF1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for MAGEF1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MAGEF1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MAGEF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAGEF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAGEF1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MAGEF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
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	shRNA in GFP-retroviral vector

Search Tocris compounds for MAGEF1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MAGEF1

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MAGEF1 Gene

protein-coding GIFtS: 47

Aliases &
Descriptions
for MAGEF1

Summaries
for MAGEF1

Genomic Location
for MAGEF1

Proteins
for MAGEF1

Protein Domains/
Families
for MAGEF1

Gene Function
for MAGEF1

Pathways & Interactions
for MAGEF1

Drugs & Compounds
for MAGEF1

Transcripts
for MAGEF1

Expression
for MAGEF1

Orthologs
for MAGEF1

Paralogs
for MAGEF1

SNPs/Variants
for MAGEF1

Disorders & Mutations
for MAGEF1

Medical News
for MAGEF1

Publications
for MAGEF1

Search for MAGEF1

Genome Databases showing MAGEF1

Other Databases showing MAGEF1

Specialized Databases showing MAGEF1

Licensable Technologies
for MAGEF1

Services
for MAGEF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAGEF1 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor MAGEF1

Summariesfor MAGEF1

Genomic Locationfor MAGEF1

Proteinsfor MAGEF1

Protein Domains/Familiesfor MAGEF1

Gene Functionfor MAGEF1

Pathways & Interactionsfor MAGEF1

Drugs & Compoundsfor MAGEF1

Transcriptsfor MAGEF1

Expression for MAGEF1

Orthologsfor MAGEF1

Paralogsfor MAGEF1

SNPs/Variantsfor MAGEF1

Disorders & Mutationsfor MAGEF1

Medical Newsfor MAGEF1

Publicationsfor MAGEF1

Search for MAGEF1

Genome Databases showing MAGEF1

Other Databases showing MAGEF1

Specialized Databases showing MAGEF1

Licensable Technologiesfor MAGEF1

Servicesfor MAGEF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAGEF1

Summaries
for MAGEF1

Genomic Location
for MAGEF1

Proteins
for MAGEF1

Protein Domains/
Families
for MAGEF1

Gene Function
for MAGEF1

Pathways & Interactions
for MAGEF1

Drugs & Compounds
for MAGEF1

Transcripts
for MAGEF1

Expression
for MAGEF1

Orthologs
for MAGEF1

Paralogs
for MAGEF1

SNPs/Variants
for MAGEF1

Disorders & Mutations
for MAGEF1

Medical News
for MAGEF1

Publications
for MAGEF1

Licensable Technologies
for MAGEF1

Services
for MAGEF1