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Aliases for MAGEF1 Gene

Aliases for MAGEF1 Gene

  • MAGE Family Member F1 2 3 5
  • Melanoma Antigen Family F1 2
  • MAGE-F1 Antigen 4

External Ids for MAGEF1 Gene

Previous GeneCards Identifiers for MAGEF1 Gene

  • GC03M181388
  • GC03M185611
  • GC03M185830
  • GC03M185749
  • GC03M185910
  • GC03M184428
  • GC03M181838

Summaries for MAGEF1 Gene

Entrez Gene Summary for MAGEF1 Gene

  • This intronless gene encodes a member of the MAGE superfamily. It is ubiquitously expressed in normal tissues and in tumor cells. This gene includes a microsatellite repeat in the coding region. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEF1 Gene

MAGEF1 (MAGE Family Member F1) is a Protein Coding gene. An important paralog of this gene is MAGEC3.

UniProtKB/Swiss-Prot for MAGEF1 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEF1 Gene

Genomics for MAGEF1 Gene

Regulatory Elements for MAGEF1 Gene

Enhancers for MAGEF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAGEF1 on UCSC Golden Path with GeneCards custom track

Promoters for MAGEF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAGEF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAGEF1 Gene

184,710,367 bp from pter
184,712,048 bp from pter
1,682 bases
Minus strand

Genomic View for MAGEF1 Gene

Genes around MAGEF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEF1 Gene

Proteins for MAGEF1 Gene

  • Protein details for MAGEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen F1
    Protein Accession:
    Secondary Accessions:
    • Q9H215

    Protein attributes for MAGEF1 Gene

    307 amino acids
    Molecular mass:
    35222 Da
    Quaternary structure:
    • Interacts with LNX1, TRIM27 and NSMCE1.

neXtProt entry for MAGEF1 Gene

Proteomics data for MAGEF1 Gene at MOPED

Post-translational modifications for MAGEF1 Gene

  • Ubiquitination at Lys 251
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MAGEF1 Gene

Domains & Families for MAGEF1 Gene

Gene Families for MAGEF1 Gene

Protein Domains for MAGEF1 Gene


Suggested Antigen Peptide Sequences for MAGEF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MAGE domain.
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEF1: view

Function for MAGEF1 Gene

Molecular function for MAGEF1 Gene

UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Phenotypes for MAGEF1 Gene

genes like me logo Genes that share phenotypes with MAGEF1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEF1 Gene

Localization for MAGEF1 Gene

Subcellular locations from

Jensen Localization Image for MAGEF1 Gene COMPARTMENTS Subcellular localization image for MAGEF1 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEF1 Gene

Pathways & Interactions for MAGEF1 Gene

SuperPathways for MAGEF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEF1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAGEF1 Gene

Drugs & Compounds for MAGEF1 Gene

No Compound Related Data Available

Transcripts for MAGEF1 Gene

mRNA/cDNA for MAGEF1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(316) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEF1 Gene

Melanoma antigen family F, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEF1 Gene

No ASD Table

Relevant External Links for MAGEF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEF1 Gene

mRNA expression in normal human tissues for MAGEF1 Gene

Protein differential expression in normal tissues from HIPED for MAGEF1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEF1 Gene

SOURCE GeneReport for Unigene cluster for MAGEF1 Gene Hs.306123

mRNA Expression by UniProt/SwissProt for MAGEF1 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MAGEF1: view

Protein tissue co-expression partners for MAGEF1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAGEF1 Gene

Orthologs for MAGEF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAGEF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAGEF1 35
  • 87.81 (n)
  • 85.91 (a)
  • 83 (a)
(Canis familiaris)
Mammalia MAGEF1 35
  • 88.29 (n)
  • 86.38 (a)
  • 85 (a)
(Pan troglodytes)
Mammalia MAGEF1 35
  • 98.7 (n)
  • 97.72 (a)
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
-- 36
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
(Gallus gallus)
Aves MAGE 36
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 43 (a)
(Danio rerio)
Actinopterygii ndnl2 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for MAGEF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAGEF1 Gene

Gene Tree for MAGEF1 (if available)
Gene Tree for MAGEF1 (if available)

Paralogs for MAGEF1 Gene

genes like me logo Genes that share paralogs with MAGEF1: view

Variants for MAGEF1 Gene

Sequence variations from dbSNP and Humsavar for MAGEF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs34540780 - 184,711,544(-) CAAGA(A/G)GAAGA reference, missense
rs12011 -- 184,711,930(-) GCTCC(C/T)TGTAC utr-variant-5-prime
rs4444691 -- 184,709,999(+) CTCCG(C/T)CTCCT downstream-variant-500B
rs10212515 -- 184,710,247(+) CTCAT(G/T)GCACT downstream-variant-500B
rs10628735 -- 184,712,843(+) TTTTT(-/TT)GCGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAGEF1 Gene

Variant ID Type Subtype PubMed ID
nsv829816 CNV Loss 17160897
nsv508973 CNV Insertion 20534489

Variation tolerance for MAGEF1 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.13; 87.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAGEF1 Gene

Disorders for MAGEF1 Gene

Relevant External Links for MAGEF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAGEF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGEF1 Gene

Publications for MAGEF1 Gene

  1. MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily. (PMID: 11313144) Stone B. … Nelson B.H. (Gene 2001) 2 3 4 67
  2. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3
  3. Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase. (PMID: 24911587) Gur I. … Yoshikawa K. (PLoS ONE 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for MAGEF1 Gene

Sources for MAGEF1 Gene