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Aliases for MAGEE2 Gene

Aliases for MAGEE2 Gene

  • MAGE Family Member E2 2 3 5
  • Hepatocellular Carcinoma-Associated Protein 3 3 4
  • Melanoma Antigen Family E2 2 3
  • MAGE-E2 Antigen 3 4
  • HCA3 3 4
  • Hepatocellular Carcinoma-Associated Protein HCA3 3
  • Melanoma-Associated Antigen E2 3
  • Melanoma Antigen Family E, 2 3

External Ids for MAGEE2 Gene

Previous GeneCards Identifiers for MAGEE2 Gene

  • GC0XM073870
  • GC0XM074785
  • GC0XM074919
  • GC0XM075002
  • GC0XM068636

Summaries for MAGEE2 Gene

Entrez Gene Summary for MAGEE2 Gene

  • This gene encodes a member of the E subfamily of MAGE (melanoma antigen-encoding gene) gene family. The gene is intronless and the encoded protein has two of the MAGE domains which are characteristic of MAGE family proteins. [provided by RefSeq, Sep 2011]

GeneCards Summary for MAGEE2 Gene

MAGEE2 (MAGE Family Member E2) is a Protein Coding gene. Diseases associated with MAGEE2 include Melanoma. An important paralog of this gene is MAGEE1.

Additional gene information for MAGEE2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEE2 Gene

Genomics for MAGEE2 Gene

Regulatory Elements for MAGEE2 Gene

Enhancers for MAGEE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH075738 0.3 FANTOM5 5.4 +46.4 46395 0 MAGEE2 ZDHHC15 GC0XP075736 TTC3P1
GH0XH075785 0.4 Ensembl 0.7 +0.1 144 0 NRF1 MAGEE2 GC0XM075746
GH0XH075746 0.4 ENCODE 0.3 +38.1 38093 1 SCRT2 GABPA GC0XM075746 MAGEE2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAGEE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAGEE2 Gene

75,782,988 bp from pter
75,785,244 bp from pter
2,257 bases
Minus strand

Genomic View for MAGEE2 Gene

Genes around MAGEE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEE2 Gene

Proteins for MAGEE2 Gene

  • Protein details for MAGEE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen E2
    Protein Accession:
    Secondary Accessions:
    • Q5JSI5

    Protein attributes for MAGEE2 Gene

    523 amino acids
    Molecular mass:
    60378 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEE2 Gene

Post-translational modifications for MAGEE2 Gene

No Post-translational modifications

Other Protein References for MAGEE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEE2 Gene

Domains & Families for MAGEE2 Gene

Gene Families for MAGEE2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEE2 Gene


Suggested Antigen Peptide Sequences for MAGEE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEE2: view

No data available for UniProtKB/Swiss-Prot for MAGEE2 Gene

Function for MAGEE2 Gene

Phenotypes for MAGEE2 Gene

GenomeRNAi human phenotypes for MAGEE2:
genes like me logo Genes that share phenotypes with MAGEE2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAGEE2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEE2 Gene

Localization for MAGEE2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEE2 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MAGEE2 Gene

Pathways & Interactions for MAGEE2 Gene

SuperPathways for MAGEE2 Gene

No Data Available

Interacting Proteins for MAGEE2 Gene

Gene Ontology (GO) - Biological Process for MAGEE2 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAGEE2 Gene

Drugs & Compounds for MAGEE2 Gene

No Compound Related Data Available

Transcripts for MAGEE2 Gene

mRNA/cDNA for MAGEE2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEE2 Gene

Melanoma antigen family E, 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAGEE2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEE2 Gene

No ASD Table

Relevant External Links for MAGEE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEE2 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEE2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.9), Brain - Frontal Cortex (BA9) (x5.4), Brain - Hypothalamus (x5.1), Brain - Cerebellum (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.4), and Brain - Cortex (x4.3).

Protein differential expression in normal tissues from HIPED for MAGEE2 Gene

This gene is overexpressed in Heart (41.6) and CD4 Tcells (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEE2 Gene

Protein tissue co-expression partners for MAGEE2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGEE2 Gene:


SOURCE GeneReport for Unigene cluster for MAGEE2 Gene:

genes like me logo Genes that share expression patterns with MAGEE2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEE2 Gene

Orthologs for MAGEE2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAGEE2 33
  • 99.35 (n)
(Bos Taurus)
Mammalia MAGEE2 33 34
  • 89.46 (n)
(Canis familiaris)
Mammalia MAGEE2 33 34
  • 89.14 (n)
(Mus musculus)
Mammalia Magee2 33 16 34
  • 86.22 (n)
(Rattus norvegicus)
Mammalia Magee2 33
  • 86.22 (n)
Species where no ortholog for MAGEE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEE2 Gene

Gene Tree for MAGEE2 (if available)
Gene Tree for MAGEE2 (if available)

Paralogs for MAGEE2 Gene

(8) SIMAP similar genes for MAGEE2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAGEE2: view

Variants for MAGEE2 Gene

Sequence variations from dbSNP and Humsavar for MAGEE2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1002821756 -- 75,785,589(+) GGAGG(G/T)CGCTA intron-variant, upstream-variant-2KB
rs1002832729 -- 75,782,625(+) TGTCC(C/G)CAGCC intron-variant, downstream-variant-500B
rs1004248089 -- 75,782,601(+) AATAG(A/G)TGTCA intron-variant, downstream-variant-500B
rs1004832128 -- 75,786,147(+) ATTGC(A/G)GGCAG intron-variant, upstream-variant-2KB
rs1006183717 -- 75,784,327(+) TGCCA(G/T)ACACC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAGEE2 Gene

Variant ID Type Subtype PubMed ID
esv2752334 CNV gain 17911159

Variation tolerance for MAGEE2 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.96; 91.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEE2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEE2 Gene

Disorders for MAGEE2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEE2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAGEE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEE2 Gene

Publications for MAGEE2 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. An overview of the MAGE gene family with the identification of all human members of the family. (PMID: 11454705) Chomez P … Lucas S (Cancer research 2001) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for MAGEE2 Gene

Sources for MAGEE2 Gene

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