MAGEE2 Gene
protein-coding GIFtS: 45
GCID: GC0XM075002
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|
melanoma antigen family E, 2
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Aliases
for MAGEE2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family E, 21 2 | | HCA31 2 3 | | Hepatocellular Carcinoma-Associated Protein 32 3 | | MAGE-E2 Antigen2 3 | | Hepatocellular Carcinoma-Associated Protein HCA32 | | Melanoma-Associated Antigen E22 |
Export aliases for MAGEE2 gene to outside databasesPrevious GC identifers: GC0XM073870 GC0XM074785 GC0XM074919 GC0XM068636 |
Summaries
for MAGEE2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEE2:
This gene encodes a member of the E subfamily of MAGE (melanoma antigen-encoding gene) gene family. The gene isintronless and the encoded protein has two of the MAGE domains which are characteristic of MAGE family proteins.(provided by RefSeq, Sep 2011)
|
Genomic Views
for MAGEE2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEE2 gene promoter:
GR USF1 Sp1 GR-beta Arnt POU2F1 USF-1 POU2F1a Msx-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEE2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEE2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.3 Ensembl cytogenetic band: Xq13.3 HGNC cytogenetic band: Xq13MAGEE2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM075002: view genomic region
(about GC identifiers)
Start:
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75,002,823 bp from pter |
End:
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75,005,079 bp from pter |
Size:
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2,257 bases |
Orientation:
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minus strand |
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Proteins
for MAGEE2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGE2_HUMAN, Q8TD90 (See
protein sequence)Recommended Name: Melanoma-associated antigen E2 Size: 523 amino acids; 60378 Da
Secondary accessions: Q5JSI5Explore the universe of human proteins at neXtProt for MAGEE2: NX_Q8TD90
MAGEE2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_619648.1
ENSEMBL proteins: ENSP00000362457
Human Recombinant Protein Products for MAGEE2:
MAGEE2 Antibody Products:
Assay Products for MAGEE2: |
Protein
Domains /
Families
for MAGEE2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEE2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TD90ProtoNet protein and cluster: Q8TD90 UniProtKB/Swiss-Prot: MAGE2_HUMAN, Q8TD90Similarity: Contains 2 MAGE domains |
Function
for MAGEE2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEE2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEE2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MAGEE2 (NM_138703) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEE2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEE2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEE2 |
|
Pathways & Interactions
for MAGEE2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEE2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/526 Interacting proteins for MAGEE2 (Q8TD902 ENSP000003624574) via UniProtKB, MINT, STRING, and/or I2D (see all 526)About this table
|
Drugs & Compounds
for MAGEE2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEE2
Search CenterWatch for drugs/clinical trials and news about MAGEE2 / MAGE2
|
Transcripts
for MAGEE2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEE2 gene: NM_138703.4 Unigene Cluster for MAGEE2: Melanoma antigen family E, 2 Hs.356869 [show with all ESTs]Unigene Representative Sequence: NM_1387031 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000373359(uc004ecj.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEE2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEE2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAGEE2 (NM_138703) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEE2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEE2 |
Additional cDNA sequence: AF490509.1 AK094624.1 BC093964.1 BC111949.1 1 DOTS entry: DT.40109913 18 AceView cDNA sequences: AA447180 AF490509 AK094624 F01615 CR624393 NM_138703 CD636477 BX433215 F05356 CD636475 AL539705 CD636483 CD636491 CD636479 CD636489 CD636482 CD636487 AL568006
GeneLoc Exon Structure
|
Expression
for MAGEE2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEE2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTCCTTG
About this image
See MAGEE2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEE2
SOURCE GeneReport for Unigene cluster: Hs.356869
SABiosciences Custom PCR Arrays for MAGEE2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEE2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAGEE2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEE2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEE2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEE2 |
Orthologs
for MAGEE2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEE2 gene from 3/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
31(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
27(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
19(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEE2 (if available)
TreeFam Gene Tree for MAGEE2 (if available) |
Paralogs
for MAGEE2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEE2 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGEA82 MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12
- MAGED12 MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2
- MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
8 SIMAP similar genes for MAGEE2 using alignment to 1 protein entry: MAGE2_HUMAN:MAGEH1 NDNL2 MAGEF1 MAGEB2 MAGEB3 MAGEA8
NDN MAGEC4
MAGEE2 for paralogs About GeneDecksing
|
Genomic Variants
for MAGEE2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEE2 (75002823 - 75005079 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAGEE2
1 CNV: 8307
Human Gene Mutation Database (HGMD): MAGEE2
Locus Specific Mutation Databases (LSDB): MAGEE2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEE2 |
|
Disorders
/ Diseases
for MAGEE2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEE2 for disorders About GeneDecksing
OMIM gene information: 300760
OMIM disorders: --
3  diseases for MAGEE2: About MalaCardsmelanoma hepatocellular carcinoma carcinoma
Export disorders for MAGEE2 gene to outside databases
|
Publications
for MAGEE2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEE2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAGEE2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- An overview of the MAGE gene family with the identification of all human members of the family. (PubMed id 11454705)1, 3 Chomez P....Lucas S. (2001)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for MAGEE2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MAGEE2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEE2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEE2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEE2 gene:
Search GeneIP for patents involving MAGEE2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEE2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MAGEE2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAGEE2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEE2 | | | OriGene Protein Over-expression Lysate for MAGEE2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAGEE2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEE2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEE2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAGEE2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEE2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEE2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAGEE2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEE2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEE2 |
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 |  |  |  | |
| | | | Search Tocris compounds for MAGEE2 |
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 | | | MAGEE2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEE2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MAGEE2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEE2 |
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