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Aliases for MAGEE1 Gene

Aliases for MAGEE1 Gene

  • MAGE Family Member E1 2 3 5
  • Hepatocellular Carcinoma-Associated Protein 1 3 4
  • Alpha-Dystrobrevin-Associated MAGE Protein 3 4
  • Melanoma Antigen Family E1 2 3
  • MAGE-E1 Antigen 3 4
  • DAMAGE 3 4
  • HCA1 3 4
  • Hepatocellular Carcinoma-Associated HCA1 3
  • Dystrobrevin-Associated MAGE Protein 3
  • Melanoma-Associated Antigen E1 3
  • Melanoma Antigen Family E, 1 3
  • KIAA1587 4

External Ids for MAGEE1 Gene

Previous GeneCards Identifiers for MAGEE1 Gene

  • GC0XM135820
  • GC0XM138147
  • GC0XM139216
  • GC0XM139976
  • GC0XP074516
  • GC0XP075430
  • GC0XP075564
  • GC0XP069280

Summaries for MAGEE1 Gene

Entrez Gene Summary for MAGEE1 Gene

  • This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to cognitive disability. [provided by RefSeq, Mar 2010]

GeneCards Summary for MAGEE1 Gene

MAGEE1 (MAGE Family Member E1) is a Protein Coding gene. Diseases associated with MAGEE1 include Melanoma. An important paralog of this gene is TRO.

UniProtKB/Swiss-Prot for MAGEE1 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Additional gene information for MAGEE1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEE1 Gene

Genomics for MAGEE1 Gene

GeneHancer (GH) Regulatory Elements for MAGEE1 Gene

Promoters and enhancers for MAGEE1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI076427 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 550.8 +0.4 386 1.9 SAP130 NRF1 ZNF48 ZNF335 ZFHX2 POLR2A PRDM10 ZFX EGR2 MAGEE1 ZDHHC15 TTC3P1 PBDC1 GC0XP076431
GH0XI076147 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.1 -277.9 -277897 5.3 PKNOX1 ATF1 ZSCAN4 ZNF335 ZNF366 ATF7 ZEB2 ZNF585B GLIS1 PRDM1 PIR52738 ZDHHC15 TTC3P1 PBDC1 ENSG00000232186 MAGEE1 GC0XP076095
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAGEE1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGEE1 gene promoter:

Genomic Locations for MAGEE1 Gene

Genomic Locations for MAGEE1 Gene
3,701 bases
Plus strand

Genomic View for MAGEE1 Gene

Genes around MAGEE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEE1 Gene

Proteins for MAGEE1 Gene

  • Protein details for MAGEE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen E1
    Protein Accession:
    Secondary Accessions:
    • Q5JXC7
    • Q86TG0
    • Q8TD92
    • Q9H216

    Protein attributes for MAGEE1 Gene

    957 amino acids
    Molecular mass:
    103254 Da
    Quaternary structure:
    • Interacts with DTNA (By similarity). Interacts with TRIM28.
    • Sequence=BAB13413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAGEE1 Gene

neXtProt entry for MAGEE1 Gene

Post-translational modifications for MAGEE1 Gene

Other Protein References for MAGEE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEE1 Gene

Domains & Families for MAGEE1 Gene

Gene Families for MAGEE1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAGEE1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEE1: view

No data available for UniProtKB/Swiss-Prot for MAGEE1 Gene

Function for MAGEE1 Gene

Molecular function for MAGEE1 Gene

UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Phenotypes From GWAS Catalog for MAGEE1 Gene

Gene Ontology (GO) - Molecular Function for MAGEE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20864041
genes like me logo Genes that share ontologies with MAGEE1: view
genes like me logo Genes that share phenotypes with MAGEE1: view

miRNA for MAGEE1 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEE1 Gene

Localization for MAGEE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEE1 Gene

Cytoplasm, perinuclear region. Nucleus. Cell membrane. Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEE1 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAGEE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 14623885
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane ISS 14623885
GO:0016010 colocalizes_with dystrophin-associated glycoprotein complex IEA,ISS 14623885
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MAGEE1: view

Pathways & Interactions for MAGEE1 Gene

SuperPathways for MAGEE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEE1: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEE1 Gene

Drugs & Compounds for MAGEE1 Gene

No Compound Related Data Available

Transcripts for MAGEE1 Gene

mRNA/cDNA for MAGEE1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEE1 Gene

Melanoma antigen family E, 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEE1 Gene

No ASD Table

Relevant External Links for MAGEE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEE1 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEE1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.3), Brain - Anterior cingulate cortex (BA24) (x4.1), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for MAGEE1 Gene

This gene is overexpressed in Stomach (62.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGEE1 Gene:


SOURCE GeneReport for Unigene cluster for MAGEE1 Gene:


Evidence on tissue expression from TISSUES for MAGEE1 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with MAGEE1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEE1 Gene

Orthologs for MAGEE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAGEE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAGEE1 33 34
  • 98.27 (n)
(Rattus norvegicus)
Mammalia Magee1 33
  • 76.09 (n)
(Mus musculus)
Mammalia Magee1 33 16 34
  • 74.23 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAN4 36
Species where no ortholog for MAGEE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEE1 Gene

Gene Tree for MAGEE1 (if available)
Gene Tree for MAGEE1 (if available)

Paralogs for MAGEE1 Gene Pseudogenes for MAGEE1 Gene

genes like me logo Genes that share paralogs with MAGEE1: view

Variants for MAGEE1 Gene

Sequence variations from dbSNP and Humsavar for MAGEE1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
VAR_036585 A breast cancer sample p.Tyr640Phe
VAR_036586 A breast cancer sample p.Thr664Asn
rs1000589097 -- 76,427,866(+) C/A 5_prime_UTR_variant
rs1000938436 -- 76,428,162(+) A/T coding_sequence_variant, missense_variant
rs1004099932 -- 76,429,266(+) G/A/T coding_sequence_variant, missense_variant

Variation tolerance for MAGEE1 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEE1 Gene

Disorders for MAGEE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEE1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MAGEE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEE1 Gene

Publications for MAGEE1 Gene

  1. Frequent MAGE mutations in human melanoma. (PMID: 20862285) Caballero OL … Simpson AJ (PloS one 2010) 3 44 58
  2. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle JM … Potts PR (Molecular cell 2010) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes. (PMID: 14623885) Albrecht DE … Froehner SC (The Journal of biological chemistry 2004) 2 3 58
  5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58

Products for MAGEE1 Gene

Sources for MAGEE1 Gene

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