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Aliases for MAGEE1 Gene

Aliases for MAGEE1 Gene

  • MAGE Family Member E1 2 3 5
  • Hepatocellular Carcinoma-Associated Protein 1 3 4
  • Alpha-Dystrobrevin-Associated MAGE Protein 3 4
  • Melanoma Antigen Family E1 2 3
  • MAGE-E1 Antigen 3 4
  • DAMAGE 3 4
  • HCA1 3 4
  • Hepatocellular Carcinoma-Associated HCA1 3
  • Dystrobrevin-Associated MAGE Protein 3
  • Melanoma-Associated Antigen E1 3
  • Melanoma Antigen Family E, 1 3
  • KIAA1587 4

External Ids for MAGEE1 Gene

Previous GeneCards Identifiers for MAGEE1 Gene

  • GC0XM135820
  • GC0XM138147
  • GC0XM139216
  • GC0XM139976
  • GC0XP074516
  • GC0XP075430
  • GC0XP075564
  • GC0XP069280

Summaries for MAGEE1 Gene

Entrez Gene Summary for MAGEE1 Gene

  • This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to mental retardation. [provided by RefSeq, Mar 2010]

GeneCards Summary for MAGEE1 Gene

MAGEE1 (MAGE Family Member E1) is a Protein Coding gene. Diseases associated with MAGEE1 include Melanoma. An important paralog of this gene is MAGEL2.

UniProtKB/Swiss-Prot for MAGEE1 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEE1 Gene

Genomics for MAGEE1 Gene

Regulatory Elements for MAGEE1 Gene

Enhancers for MAGEE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG076147 1.3 Ensembl ENCODE dbSUPER 4 -277.9 -277898 5.3 PKNOX1 ATF1 ZSCAN4 ZBTB40 ZNF366 FOS ZEB2 RAD51 ZNF585B GLIS1 PBDC1 ZDHHC15 ENSG00000232186 MAGEE1 PIR52738 GC0XP076095
GH0XG076427 0.6 ENCODE 0.7 +0.2 205 1.6 ZFHX2 SAP130 POLR2A NRF1 PRDM10 ZFX ZNF48 EGR2 ZDHHC15 TTC3P1 GC0XP076431 MAGEE1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAGEE1 on UCSC Golden Path with GeneCards custom track

Promoters for MAGEE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247301 548 1600 ELF3 MLX ZNF48 RARA GATA4 CREM MIXL1 EGR2 PPARG KAT8

Genomic Location for MAGEE1 Gene

Chromosome:
X
Start:
76,427,653 bp from pter
End:
76,431,353 bp from pter
Size:
3,701 bases
Orientation:
Plus strand

Genomic View for MAGEE1 Gene

Genes around MAGEE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEE1 Gene

Proteins for MAGEE1 Gene

  • Protein details for MAGEE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCI5-MAGE1_HUMAN
    Recommended name:
    Melanoma-associated antigen E1
    Protein Accession:
    Q9HCI5
    Secondary Accessions:
    • Q5JXC7
    • Q86TG0
    • Q8TD92
    • Q9H216

    Protein attributes for MAGEE1 Gene

    Size:
    957 amino acids
    Molecular mass:
    103254 Da
    Quaternary structure:
    • Interacts with DTNA (By similarity). Interacts with TRIM28.
    SequenceCaution:
    • Sequence=BAB13413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAGEE1 Gene

neXtProt entry for MAGEE1 Gene

Post-translational modifications for MAGEE1 Gene

  • Ubiquitination at posLast=734734
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEE1 Gene

Domains & Families for MAGEE1 Gene

Gene Families for MAGEE1 Gene

Protein Domains for MAGEE1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEE1: view

No data available for UniProtKB/Swiss-Prot for MAGEE1 Gene

Function for MAGEE1 Gene

Molecular function for MAGEE1 Gene

UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Ontology (GO) - Molecular Function for MAGEE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20864041
genes like me logo Genes that share ontologies with MAGEE1: view
genes like me logo Genes that share phenotypes with MAGEE1: view

Animal Model Products

CRISPR Products

miRNA for MAGEE1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEE1 Gene

Localization for MAGEE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEE1 Gene

Cytoplasm, perinuclear region. Nucleus. Cell membrane. Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEE1 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAGEE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 14623885
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane ISS 14623885
GO:0016010 colocalizes_with dystrophin-associated glycoprotein complex IEA,ISS 14623885
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MAGEE1: view

Pathways & Interactions for MAGEE1 Gene

SuperPathways for MAGEE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEE1: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEE1 Gene

Transcripts for MAGEE1 Gene

mRNA/cDNA for MAGEE1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEE1 Gene

Melanoma antigen family E, 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEE1 Gene

No ASD Table

Relevant External Links for MAGEE1 Gene

GeneLoc Exon Structure for
MAGEE1
ECgene alternative splicing isoforms for
MAGEE1

Expression for MAGEE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEE1 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEE1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.3), Brain - Anterior cingulate cortex (BA24) (x4.1), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for MAGEE1 Gene

This gene is overexpressed in Stomach (62.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEE1 Gene



NURSA nuclear receptor signaling pathways regulating expression of MAGEE1 Gene:

MAGEE1

SOURCE GeneReport for Unigene cluster for MAGEE1 Gene:

Hs.8453

Evidence on tissue expression from TISSUES for MAGEE1 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with MAGEE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEE1 Gene

Orthologs for MAGEE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAGEE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEE1 34 35
  • 98.27 (n)
rat
(Rattus norvegicus)
Mammalia Magee1 34
  • 76.09 (n)
mouse
(Mus musculus)
Mammalia Magee1 34 16 35
  • 74.23 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAN4 37
Species where no ortholog for MAGEE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEE1 Gene

ENSEMBL:
Gene Tree for MAGEE1 (if available)
TreeFam:
Gene Tree for MAGEE1 (if available)

Paralogs for MAGEE1 Gene

Pseudogenes.org Pseudogenes for MAGEE1 Gene

genes like me logo Genes that share paralogs with MAGEE1: view

Variants for MAGEE1 Gene

Sequence variations from dbSNP and Humsavar for MAGEE1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036585 A breast cancer sample
VAR_036586 A breast cancer sample
rs1000589097 -- 76,427,866(+) CCCGT(A/C)CTCTC utr-variant-5-prime
rs1000938436 -- 76,428,162(+) CAAGC(A/T)CCTTT reference, missense
rs1004099932 -- 76,429,266(+) ACTCA(G/T)ATTCT reference, missense

Variation tolerance for MAGEE1 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEE1 Gene

Disorders for MAGEE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEE1

Genetic Association Database (GAD)
MAGEE1
Human Genome Epidemiology (HuGE) Navigator
MAGEE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEE1
genes like me logo Genes that share disorders with MAGEE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEE1 Gene

Publications for MAGEE1 Gene

  1. Frequent MAGE mutations in human melanoma. (PMID: 20862285) Caballero O.L. … Simpson A.J. (PLoS ONE 2010) 3 46 64
  2. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle J.M. … Potts P.R. (Mol. Cell 2010) 3 4 64
  3. DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes. (PMID: 14623885) Albrecht D.E. … Froehner S.C. (J. Biol. Chem. 2004) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64

Products for MAGEE1 Gene

Sources for MAGEE1 Gene

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