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Aliases for MAGEE1 Gene

Aliases for MAGEE1 Gene

  • Melanoma Antigen Family E1 2 3
  • Hepatocellular Carcinoma-Associated Protein 1 3 4
  • Alpha-Dystrobrevin-Associated MAGE Protein 3 4
  • MAGE-E1 Antigen 3 4
  • DAMAGE 3 4
  • HCA1 3 4
  • Hepatocellular Carcinoma-Associated HCA1 3
  • Dystrobrevin-Associated MAGE Protein 3
  • Melanoma Antigen Family E, 1 3
  • KIAA1587 4

External Ids for MAGEE1 Gene

Previous GeneCards Identifiers for MAGEE1 Gene

  • GC0XM135820
  • GC0XM138147
  • GC0XM139216
  • GC0XM139976
  • GC0XP074516
  • GC0XP075430
  • GC0XP075564
  • GC0XP069280

Summaries for MAGEE1 Gene

Entrez Gene Summary for MAGEE1 Gene

  • This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to mental retardation. [provided by RefSeq, Mar 2010]

GeneCards Summary for MAGEE1 Gene

MAGEE1 (Melanoma Antigen Family E1) is a Protein Coding gene. Diseases associated with MAGEE1 include melanoma. An important paralog of this gene is MAGEC3.

UniProtKB/Swiss-Prot for MAGEE1 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEE1 Gene

Genomics for MAGEE1 Gene

Regulatory Elements for MAGEE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAGEE1 Gene

Chromosome:
X
Start:
76,427,653 bp from pter
End:
76,431,353 bp from pter
Size:
3,701 bases
Orientation:
Plus strand

Genomic View for MAGEE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEE1 Gene

Proteins for MAGEE1 Gene

  • Protein details for MAGEE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCI5-MAGE1_HUMAN
    Recommended name:
    Melanoma-associated antigen E1
    Protein Accession:
    Q9HCI5
    Secondary Accessions:
    • Q5JXC7
    • Q86TG0
    • Q8TD92
    • Q9H216

    Protein attributes for MAGEE1 Gene

    Size:
    957 amino acids
    Molecular mass:
    103254 Da
    Quaternary structure:
    • Interacts with DTNA (By similarity). Interacts with TRIM28.
    SequenceCaution:
    • Sequence=BAB13413.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAGEE1 Gene

neXtProt entry for MAGEE1 Gene

Proteomics data for MAGEE1 Gene at MOPED

Post-translational modifications for MAGEE1 Gene

  • Ubiquitination at Lys 734
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEE1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEE1 Gene

Domains & Families for MAGEE1 Gene

Gene Families for MAGEE1 Gene

Protein Domains for MAGEE1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9HCI5

UniProtKB/Swiss-Prot:

MAGE1_HUMAN :
  • Contains 2 MAGE domains.
Domain:
  • Contains 2 MAGE domains.
genes like me logo Genes that share domains with MAGEE1: view

Function for MAGEE1 Gene

Molecular function for MAGEE1 Gene

UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Ontology (GO) - Molecular Function for MAGEE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20864041
genes like me logo Genes that share ontologies with MAGEE1: view

Phenotypes for MAGEE1 Gene

GenomeRNAi human phenotypes for MAGEE1:
genes like me logo Genes that share phenotypes with MAGEE1: view

Animal Model Products

miRNA for MAGEE1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEE1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEE1 Gene

Localization for MAGEE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEE1 Gene

Cytoplasm, perinuclear region. Nucleus. Cell membrane. Note=In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEE1 Gene COMPARTMENTS Subcellular localization image for MAGEE1 gene
Compartment Confidence
nucleus 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for MAGEE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 14623885
GO:0005886 plasma membrane ISS 14623885
GO:0016010 colocalizes_with dystrophin-associated glycoprotein complex ISS 14623885
GO:0030425 dendrite ISS 14623885
GO:0045211 postsynaptic membrane ISS 14623885
genes like me logo Genes that share ontologies with MAGEE1: view

Pathways & Interactions for MAGEE1 Gene

SuperPathways for MAGEE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEE1: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEE1 Gene

Drugs & Compounds for MAGEE1 Gene

No Compound Related Data Available

Transcripts for MAGEE1 Gene

mRNA/cDNA for MAGEE1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEE1 Gene

Melanoma antigen family E, 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEE1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEE1 Gene

No ASD Table

Relevant External Links for MAGEE1 Gene

GeneLoc Exon Structure for
MAGEE1
ECgene alternative splicing isoforms for
MAGEE1

Expression for MAGEE1 Gene

mRNA expression in normal human tissues for MAGEE1 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEE1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.3), Brain - Anterior cingulate cortex (BA24) (x4.1), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for MAGEE1 Gene

This gene is overexpressed in Stomach (62.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEE1 Gene



SOURCE GeneReport for Unigene cluster for MAGEE1 Gene Hs.8453

genes like me logo Genes that share expression patterns with MAGEE1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MAGEE1 Gene

Orthologs for MAGEE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAGEE1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Magee1 35
  • 74.23 (n)
  • 65.64 (a)
Magee1 16
Magee1 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAGEE1 35
  • 98.27 (n)
  • 97.79 (a)
MAGEE1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Magee1 35
  • 76.09 (n)
  • 68.26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAN4 38
Species with no ortholog for MAGEE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEE1 Gene

ENSEMBL:
Gene Tree for MAGEE1 (if available)
TreeFam:
Gene Tree for MAGEE1 (if available)

Paralogs for MAGEE1 Gene

Paralogs for MAGEE1 Gene

Pseudogenes.org Pseudogenes for MAGEE1 Gene

genes like me logo Genes that share paralogs with MAGEE1: view

Variants for MAGEE1 Gene

Sequence variations from dbSNP and Humsavar for MAGEE1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2144455 -- 76,431,715(-) TGAGC(C/T)GAGAT downstream-variant-500B
rs6647995 -- 76,426,541(+) CAATA(A/G)AGGGT upstream-variant-2KB
rs6647996 -- 76,427,234(+) CAGGC(A/T)TTCAG upstream-variant-2KB
rs7051260 - 76,428,947(+) GAGGA(C/G)TTGAG missense, reference
rs7066146 -- 76,428,158(+) GGCCC(A/C)AGCAC reference, synonymous-codon

Variation tolerance for MAGEE1 Gene

Residual Variation Intolerance Score: 73.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEE1 Gene

HapMap Linkage Disequilibrium report
MAGEE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEE1 Gene

Disorders for MAGEE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association

Relevant External Links for MAGEE1

Genetic Association Database (GAD)
MAGEE1
Human Genome Epidemiology (HuGE) Navigator
MAGEE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEE1
genes like me logo Genes that share disorders with MAGEE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEE1 Gene

Publications for MAGEE1 Gene

  1. DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes. (PMID: 14623885) Albrecht D.E. … Froehner S.C. (J. Biol. Chem. 2004) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition. (PMID: 23268337) Doyle J.R. … Kopin A.S. (J. Lipid Res. 2013) 67
  4. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. (PMID: 22632162) Lin C.W. … Jan M.S. (J Drug Target 2012) 67
  5. Frequent MAGE mutations in human melanoma. (PMID: 20862285) Caballero O.L. … Simpson A.J. (PLoS ONE 2010) 67

Products for MAGEE1 Gene

Sources for MAGEE1 Gene

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