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Aliases for MAGED4B Gene

Aliases for MAGED4B Gene

  • MAGE Family Member D4B 2 5
  • Melanoma Antigen Family D4B 2 3
  • MAGE-E1 Antigen 4
  • MAGE-D4 Antigen 4
  • MAGED4 MAGED4B 4
  • KIAA1859 4
  • MAGED4A 4
  • MAGEE1 4

External Ids for MAGED4B Gene

Previous GeneCards Identifiers for MAGED4B Gene

  • GC0XU900705
  • GC0XM051822
  • GC0XM049240
  • GC0XM051805

Summaries for MAGED4B Gene

Entrez Gene Summary for MAGED4B Gene

  • This gene is a member of the MAGED gene family. It is expressed only in brain and ovary, and some transcript variants of this gene are specifically expressed in glioma cells. This gene is clustered with other MAGED genes on chromosome Xp11. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for MAGED4B Gene

MAGED4B (MAGE Family Member D4B) is a Protein Coding gene. Diseases associated with MAGED4B include Glioma. An important paralog of this gene is MAGEC3.

UniProtKB/Swiss-Prot for MAGED4B Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Wiki entry for MAGED4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGED4B Gene

Genomics for MAGED4B Gene

Regulatory Elements for MAGED4B Gene


Promoters for MAGED4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAGED4B on UCSC Golden Path with GeneCards custom track

Genomic Location for MAGED4B Gene

Chromosome:
X
Start:
52,061,827 bp from pter
End:
52,069,272 bp from pter
Size:
7,446 bases
Orientation:
Minus strand

Genomic View for MAGED4B Gene

Genes around MAGED4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGED4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGED4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGED4B Gene

Proteins for MAGED4B Gene

  • Protein details for MAGED4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JG8-MAGD4_HUMAN
    Recommended name:
    Melanoma-associated antigen D4
    Protein Accession:
    Q96JG8
    Secondary Accessions:
    • A8K093
    • Q5HYN6
    • Q8WXW4
    • Q9BQ84
    • Q9BVH1
    • Q9BYH3
    • Q9BYH4
    • Q9H217

    Protein attributes for MAGED4B Gene

    Size:
    741 amino acids
    Molecular mass:
    81378 Da
    Quaternary structure:
    • Interacts with TRIM27.
    • Interacts with TRIM27.
    SequenceCaution:
    • Sequence=AAH01207.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL50032.1; Type=Frameshift; Positions=186, 219; Evidence={ECO:0000305}; Sequence=BAB47488.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAGED4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGED4B Gene

Proteomics data for MAGED4B Gene at MOPED

Post-translational modifications for MAGED4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGED4B Gene

Domains & Families for MAGED4B Gene

Gene Families for MAGED4B Gene

Protein Domains for MAGED4B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGED4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JG8

UniProtKB/Swiss-Prot:

MAGD4_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGED4B: view

Function for MAGED4B Gene

Molecular function for MAGED4B Gene

UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Phenotypes for MAGED4B Gene

genes like me logo Genes that share phenotypes with MAGED4B: view

Animal Model Products

CRISPR Products

miRNA for MAGED4B Gene

miRTarBase miRNAs that target MAGED4B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGED4B Gene

Localization for MAGED4B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGED4B Gene COMPARTMENTS Subcellular localization image for MAGED4B gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGED4B Gene

Pathways & Interactions for MAGED4B Gene

SuperPathways for MAGED4B Gene

No Data Available

Interacting Proteins for MAGED4B Gene

Gene Ontology (GO) - Biological Process for MAGED4B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGED4B Gene

Drugs & Compounds for MAGED4B Gene

(1) Additional Compounds for MAGED4B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAGED4B: view

Transcripts for MAGED4B Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MAGED4B Gene

No ASD Table

Relevant External Links for MAGED4B Gene

GeneLoc Exon Structure for
MAGED4B
ECgene alternative splicing isoforms for
MAGED4B

Expression for MAGED4B Gene

mRNA expression in normal human tissues for MAGED4B Gene

mRNA differential expression in normal tissues according to GTEx for MAGED4B Gene

This gene is overexpressed in Brain - Hypothalamus (x9.7) and Brain - Amygdala (x4.3).

Protein differential expression in normal tissues from HIPED for MAGED4B Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MAGED4B Gene



mRNA Expression by UniProt/SwissProt for MAGED4B Gene

Q96JG8-MAGD4_HUMAN
Tissue specificity: Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples.
genes like me logo Genes that share expression patterns with MAGED4B: view

Protein tissue co-expression partners for MAGED4B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGED4B Gene

Orthologs for MAGED4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAGED4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAGED4B 35
  • 88.48 (n)
  • 86.72 (a)
-- 36
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC480926 35
  • 90.23 (n)
  • 89.86 (a)
-- 36
  • 90 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC465643 35
  • 99.81 (n)
  • 99.72 (a)
-- 36
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAGE 36
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ndnl2 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for MAGED4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAGED4B Gene

ENSEMBL:
Gene Tree for MAGED4B (if available)
TreeFam:
Gene Tree for MAGED4B (if available)

Paralogs for MAGED4B Gene

Pseudogenes.org Pseudogenes for MAGED4B Gene

genes like me logo Genes that share paralogs with MAGED4B: view

Variants for MAGED4B Gene

Sequence variations from dbSNP and Humsavar for MAGED4B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs200011554 -- 52,067,978(+) CGAAG(A/G)CCTGG reference, synonymous-codon
rs373827485 -- 52,062,160(+) CACCC(C/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGED4B Gene

Variant ID Type Subtype PubMed ID
nsv516643 CNV Gain 19592680

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for MAGED4B Gene

Disorders for MAGED4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGED4B Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
glioma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGED4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGED4B
genes like me logo Genes that share disorders with MAGED4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGED4B Gene

Publications for MAGED4B Gene

  1. Structural characterization and chromosomal localization of the MAGE- E1 gene. (PMID: 11602350) Kawano Y. … Ikenaka K. (Gene 2001) 3 4 23 67
  2. Expression of MAGE-D4, a novel MAGE family antigen, is correlated with tumor-cell proliferation of non-small cell lung cancer. (PMID: 16225959) Ito S. … Tanaka F. (Lung Cancer 2006) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Evaluation of MAGE-D4 expression in hepatocellular carcinoma in Japanese patients. (PMID: 24068544) Takami H. … Kodera Y. (J Surg Oncol 2013) 3
  5. MAGE-D4B is a novel marker of poor prognosis and potential therapeutic target involved in breast cancer tumorigenesis. (PMID: 21618523) Germano S. … O'Driscoll L. (Int. J. Cancer 2012) 3

Products for MAGED4B Gene

Sources for MAGED4B Gene

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