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Aliases for MAGED4B Gene

Aliases for MAGED4B Gene

  • Melanoma Antigen Family D4B 2 3
  • MAGE-D4 Antigen 4
  • MAGE-E1 Antigen 4
  • KIAA1859 4
  • MAGED4A 4
  • MAGEE1 4

External Ids for MAGED4B Gene

Previous GeneCards Identifiers for MAGED4B Gene

  • GC0XU900705
  • GC0XM051822
  • GC0XM049240
  • GC0XM051805

Summaries for MAGED4B Gene

Entrez Gene Summary for MAGED4B Gene

  • This gene is a member of the MAGED gene family. It is expressed only in brain and ovary, and some transcript variants of this gene are specifically expressed in glioma cells. This gene is clustered with other MAGED genes on chromosome Xp11. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for MAGED4B Gene

MAGED4B (Melanoma Antigen Family D4B) is a Protein Coding gene. Diseases associated with MAGED4B include malignant glioma and oral squamous cell carcinoma. An important paralog of this gene is MAGED1.

UniProtKB/Swiss-Prot for MAGED4B Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Wiki entry for MAGED4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGED4B Gene

Genomics for MAGED4B Gene

Regulatory Elements for MAGED4B Gene

Genomic Location for MAGED4B Gene

52,061,827 bp from pter
52,069,272 bp from pter
7,446 bases
Minus strand

Genomic View for MAGED4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGED4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGED4B Gene

Proteins for MAGED4B Gene

  • Protein details for MAGED4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen D4
    Protein Accession:
    Secondary Accessions:
    • A8K093
    • Q5HYN6
    • Q8WXW4
    • Q9BQ84
    • Q9BVH1
    • Q9BYH3
    • Q9BYH4
    • Q9H217

    Protein attributes for MAGED4B Gene

    741 amino acids
    Molecular mass:
    81378 Da
    Quaternary structure:
    • Interacts with TRIM27.
    • Sequence=AAH01207.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL50032.1; Type=Frameshift; Positions=186, 219; Evidence={ECO:0000305}; Sequence=BAB47488.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAGED4B Gene


neXtProt entry for MAGED4B Gene

Proteomics data for MAGED4B Gene at MOPED

Post-translational modifications for MAGED4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGED4B Gene

Domains for MAGED4B Gene

Protein Domains for MAGED4B Gene


Suggested Antigen Peptide Sequences for MAGED4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MAGE domain.
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGED4B: view

No data available for Gene Families for MAGED4B Gene

Function for MAGED4B Gene

Molecular function for MAGED4B Gene

UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Animal Model Products

CRISPR Products

miRNA for MAGED4B Gene

miRTarBase miRNAs that target MAGED4B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGED4B Gene

Localization for MAGED4B Gene

Subcellular locations from

Jensen Localization Image for MAGED4B Gene COMPARTMENTS Subcellular localization image for MAGED4B gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGED4B Gene

Pathways for MAGED4B Gene

SuperPathways for MAGED4B Gene

No Data Available

Interacting Proteins for MAGED4B Gene

Gene Ontology (GO) - Biological Process for MAGED4B Gene


No data available for Pathways by source for MAGED4B Gene

Drugs for MAGED4B Gene

(1) Novoseek inferred chemical compound relationships for MAGED4B Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 46.8 1
genes like me logo Genes that share compounds with MAGED4B: view

Transcripts for MAGED4B Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MAGED4B Gene

No ASD Table

Relevant External Links for MAGED4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGED4B Gene

mRNA expression in normal human tissues for MAGED4B Gene

mRNA differential expression in normal tissues according to GTEx for MAGED4B Gene

This gene is overexpressed in Brain - Hypothalamus (9.7) and Brain - Amygdala (4.3).

Protein differential expression in normal tissues for MAGED4B Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (65.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MAGED4B Gene

mRNA Expression by UniProt/SwissProt for MAGED4B Gene

Tissue specificity: Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples.
genes like me logo Genes that share expressions with MAGED4B: view

Expression partners for MAGED4B Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGED4B Gene

Orthologs for MAGED4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAGED4B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAGED4B 35
  • 88.48 (n)
  • 86.72 (a)
-- 36
  • 86 (a)
(Canis familiaris)
Mammalia LOC480926 35
  • 90.23 (n)
  • 89.86 (a)
-- 36
  • 90 (a)
(Pan troglodytes)
Mammalia LOC465643 35
  • 99.81 (n)
  • 99.72 (a)
-- 36
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
-- 36
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
(Gallus gallus)
Aves MAGE 36
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
(Danio rerio)
Actinopterygii ndnl2 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for MAGED4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAGED4B Gene

Gene Tree for MAGED4B (if available)
Gene Tree for MAGED4B (if available)

Paralogs for MAGED4B Gene Pseudogenes for MAGED4B Gene

genes like me logo Genes that share paralogs with MAGED4B: view

Variants for MAGED4B Gene

Sequence variations from dbSNP and Humsavar for MAGED4B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs200011554 -- 52,067,978(+) CGAAG(A/G)CCTGG reference, synonymous-codon
rs373827485 -- 52,062,160(+) CACCC(C/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGED4B Gene

Variant ID Type Subtype PubMed ID
nsv516643 CNV Gain 19592680

Relevant External Links for MAGED4B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGED4B Gene

Disorders for MAGED4B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MAGED4B Gene in MalaCards »

(2) Diseases for MAGED4B Gene

(10) Novoseek inferred disease relationships for MAGED4B Gene

Disease -log(P) Hits PubMed IDs
melanoma 72.3 27
metastatic melanoma 48 1
glioblastoma 47.2 2
astrocytoma 42.2 1
malignant glioma 36 1
genes like me logo Genes that share disorders with MAGED4B: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for MAGED4B Gene

Publications for MAGED4B Gene

  1. Structural characterization and chromosomal localization of the MAGE- E1 gene. (PMID: 11602350) Kawano Y. … Ikenaka K. (Gene 2001) 3 4 23
  2. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle J.M. … Potts P.R. (Mol. Cell 2010) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  5. MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma. (PMID: 11406556) Sasaki M. … Ikenaka K. (Cancer Res. 2001) 3 4

Products for MAGED4B Gene

Sources for MAGED4B Gene

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