MAGED4 Gene
protein-coding GIFtS: 43
GCID: GC0XP051927
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melanoma antigen family D, 4
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Aliases for MAGED4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family D, 41 2 | | MAGE-D4 Antigen2 3 | | KIAA18591 3 5 | | MAGE-E1 Antigen2 3 | | MAGEE12 3 5 | | MGC32101 | | MAGE-E11 2 | | Melanoma-Associated Antigen D42 | | MAGE11 2 | | MAGED4A3 |
Export aliases for MAGED4 gene to outside databasesPrevious GC identifers: GC0XP049889 GC0XP050579 GC0XM050721 GC0XM051637 GC0XM051821 GC0XP051949 GC0XP051952 |
Summaries for MAGED4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: MAGD4_HUMAN, Q96JG8Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substratecomplex
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Genomic Views for MAGED4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011638.13
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MAGED4 gene promoter: RFX1 STAT5A NF-AT HNF-4alpha1 Meis-1b IRF-7A ZID Meis-1a NF-AT1 Meis-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGED4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGED4 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11MAGED4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP051927: view genomic region
(about GC identifiers)
Start:
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51,927,919 bp from pter |
End:
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51,935,364 bp from pter |
Size:
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7,446 bases |
Orientation:
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plus strand |
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Proteins for MAGED4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: MAGD4_HUMAN, Q96JG8 (See
protein sequence)Recommended Name: Melanoma-associated antigen D4 Size: 741 amino acids; 81378 Da
Subunit: Interacts with TRIM27
Sequence caution: Sequence=AAH01207.1; Type=Erroneous initiation; Sequence=AAL50032.1; Type=Frameshift; Positions=186,219; Sequence=BAB47488.2; Type=Erroneous initiation;
Secondary accessions: A8K093 Q5HYN6 Q8WXW4 Q9BQ84 Q9BVH1 Q9BYH3 Q9BYH4 Q9H217Alternative splicing: 4 isoforms: Q96JG8-1 Q96JG8-2 Q96JG8-3 Q96JG8-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MAGED4: NX_Q96JG8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96JG8 MAGED4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001092270.1 NP_001258990.1 NP_001258991.1 NP_001258992.1 ENSEMBL proteins: ENSP00000364777 ENSP00000399147 Human Recombinant Protein Products:
MAGED4 Antibody Products: Assay Products for MAGED4: |
Protein
Domains / Families for MAGED4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGED4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96JG8ProtoNet protein and cluster: Q96JG8 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGD4_HUMAN, Q96JG8Similarity: Contains 1 MAGE domain |
Function for MAGED4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: MAGD4_HUMAN, Q96JG8Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substratecomplex
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGED4 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGED4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): MAGED4 (NM_177535) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGED4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAGED4  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGED4 |
1 GenomeRNAi human phenotype for MAGED4:
|
Pathways & Interactions for MAGED4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGED4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 5 Interacting proteins for MAGED4 (Q96JG82, 3 ENSP000003647774) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds for MAGED4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for MAGED4 Search CenterWatch for drugs/clinical trials and news about MAGED4 / MAGD4 
|
Transcripts for MAGED4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MAGED4 gene (4 alternative transcripts): NM_001098800.2 NM_001272061.1 NM_001272062.1 NM_001272063.1 Unigene Cluster for MAGED4: Melanoma antigen family D, 4 Hs.571729 [show with all ESTs]Unigene Representative Sequence: BC00120712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000471932 ENST00000459685 ENST00000488430 ENST00000375626 ENST00000477634 ENST00000498483 ENST00000467526 ENST00000474812 ENST00000479281 ENST00000497416 ENST00000497348 ENST00000416960(uc004dpz.3 uc004dpx.3 uc004dpw.3 uc004dpy.3 uc004dqa.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGED4 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGED4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): MAGED4 (NM_177535) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGED4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAGED4  |
Additional cDNA sequence: AB040527.1 AB040528.1 AB058762.2 AF320908.1 AF329733.1 AK098830.1 AL136582.1 BC001207.1 BC063838.1 BC081566.1 20 DOTS entries: DT.100681454 DT.75111770 DT.100816309 DT.92430356 DT.100816300 DT.100665895 DT.100808063 DT.100816294 DT.100816303 DT.121302770 DT.121302806 DT.121318307 DT.121318314 DT.95301976 DT.100816302 DT.100816308 DT.102825067 DT.121302697 DT.121318299 DT.40107206 GeneLoc Exon Structure
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Expression for MAGED4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGED4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See MAGED4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MAGED4
SOURCE GeneReport for Unigene cluster: Hs.571729 UniProtKB/Swiss-Prot: MAGD4_HUMAN, Q96JG8Tissue specificity: Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specificallyexpressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples SABiosciences Custom PCR Arrays for MAGED4
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGED4 Browse OriGene validated miRNA SYBR primer pairs
| |  | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MAGED4 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGED4 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGED4 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGED4 |
Orthologs for MAGED4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGED4 gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
lizard (Anolis carolinensis) |
Reptilia |
-- |
-- |
37(a) |
1 → many |
1(205669616-205678308) |
zebrafish (Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
34(a) |
1 → many |
23(13012414-13025121) |
fruit fly (Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
23(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGED4 (if available) TreeFam Gene Tree for MAGED4 (if available)  |
Paralogs for MAGED4 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for MAGED4 gene
- MAGED4B1 2 MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12
- MAGEA82 MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12
- MAGED12 MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGEE22
- MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/23 SIMAP similar genes for MAGED4 using alignment to 1 protein entry: MAGD4_HUMAN(see all similar genes):MAGED4B MAGEH1 TRO MAGEA8 MAGEB2 MAGEA3 MAGEA12 MAGEA6 MAGEF1 MAGED2 MAGEB3 MAGEC4 NDNL2 MAGEB4 MAGEA4 MAGEA1 MAGEA9 MAGEA9B
MAGED4 for paralogs About GeneDecksing
|
Genomic Variants for MAGED4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr X pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for MAGED4 (51927919 - 51935364 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MAGED4: --  | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases for MAGED4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGED4 for disorders About GeneDecksing
OMIM gene information: 300702
OMIM disorders: --
3 diseases for MAGED4: About MalaCardsmelanoma renal cell carcinoma carcinoma Export disorders for MAGED4 gene to outside databases
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Publications for MAGED4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGED4 gene, integrated from 9 sources (see all 17): (articles sorted by number of sources associating them with MAGED4) | |  | Utopia: connect your pdf to the dynamic world of online information |
- MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma. (PubMed id 11406556)1, 2, 3 Sasaki M.... Ikenaka K. (2001)
- Structural characterization and chromosomal localization of the MAGE- E1 gene. (PubMed id 11602350)1, 2 Kawano Y....Ikenaka K. (2001)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Ubiquitin-specific peptidase 9, X-linked (USP9X) modul ates activity of mammalian target of rapamycin (mTOR). (PubMed id 22544753)1 Agrawal P....Hughes R.E. (2012)
- MAGE-RING protein complexes comprise a family of E3 u biquitin ligases. (PubMed id 20864041)2 Doyle J.M....Potts P.R. (2010)
- Expression of MAGE-D4, a novel MAGE family antigen, is correlated with tumor-cell proliferation of non-small cell lung cancer. (PubMed id 16225959)1 Ito S....Tanaka F. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- MAGED4-expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue. (PubMed id 16082191)2 Kraemer B.F....Stevanovic S. (2005)
- Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (2005)
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External Searches for MAGED4 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing MAGED4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGED4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing MAGED4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for MAGED4 gene: Search GeneIP for patents involving MAGED4
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MAGED4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for MAGED4 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAGED4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGED4 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for MAGED4 | | OriGene 3'-UTR Clone for MAGED4 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGED4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGED4 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for MAGED4 | | OriGene Custom Protein Services for MAGED4 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAGED4 | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGED4 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGED4 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAGED4 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGED4 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGED4 |
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 | | MAGED4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGED4 |
|  |  |  | | | Search ThermoFisher Antibodies for MAGED4 |
| | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAGED4 |
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