Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MAGED4 Gene

protein-coding   GIFtS: 43
GCID: GC0XP051927

Melanoma Antigen Family D, 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Melanoma Antigen Family D, 41 2     MAGE-E12
MAGEE12 3 5     MAGE12
MAGE-D4 Antigen2 3     Melanoma-Associated Antigen D42
MAGE-E1 Antigen2 3     MAGED4A3
KIAA18593 5     

External Ids:    HGNC: 237931   Entrez Gene: 7282392   Ensembl: ENSG000001545457   OMIM: 3007025   UniProtKB: Q96JG83   

Export aliases for MAGED4 gene to outside databases

Previous GC identifers: GC0XP049889 GC0XP050579 GC0XM050721 GC0XM051637 GC0XM051821 GC0XP051949 GC0XP051952


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MAGED4 Gene:
MAGED4 (melanoma antigen family D, 4) is a protein-coding gene. Diseases associated with MAGED4 include melanoma, and renal cell carcinoma. An important paralog of this gene is MAGEA3.

UniProtKB/Swiss-Prot: MAGD4_HUMAN, Q96JG8
Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.
Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate
complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_018934.2  NC_000023.11  NT_011630.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAGED4 gene promoter:
         RFX1   STAT5A   NF-AT   HNF-4alpha1   Meis-1b   IRF-7A   ZID   Meis-1a   NF-AT1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGED4 promoter sequence
   Search Chromatin IP Primers for MAGED4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGED4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11

MAGED4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGED4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP051927:  view genomic region     (about GC identifiers)

Start:
51,927,919 bp from pter      End:
51,935,364 bp from pter
Size:
7,446 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MAGD4_HUMAN, Q96JG8 (See protein sequence)
Recommended Name: Melanoma-associated antigen D4  
Size: 741 amino acids; 81378 Da
Subunit: Interacts with TRIM27
Sequence caution: Sequence=AAH01207.1; Type=Erroneous initiation; Sequence=AAL50032.1; Type=Frameshift;
Positions=186, 219; Sequence=BAB47488.2; Type=Erroneous initiation;
Secondary accessions: A8K093 Q5HYN6 Q8WXW4 Q9BQ84 Q9BVH1 Q9BYH3 Q9BYH4 Q9H217
Alternative splicing: 4 isoforms:  Q96JG8-1   Q96JG8-2   Q96JG8-3   Q96JG8-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAGED4: NX_Q96JG8

Explore proteomics data for MAGED4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAGED4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001092270.1  NP_001258990.1  NP_001258991.1  NP_001258992.1  

    ENSEMBL proteins: 
     ENSP00000364777   ENSP00000399147  

    MAGED4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAGED4
    GenScript Custom Purified and Recombinant Proteins Services for MAGED4
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAGED4

    MAGED4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MAGED4
    Search for Antibodies for MAGED4 at Abcam
    Cloud-Clone Corp. Antibodies for MAGED4
    Search ThermoFisher Antibodies for MAGED4
    LSBio Antibodies in human, mouse, rat for MAGED4

    MAGED4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAGED4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAGED4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAGED4
    Cloud-Clone Corp. CLIAs for MAGED4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry Q96JG8

    ProtoNet protein and cluster: Q96JG8

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGD4_HUMAN, Q96JG8
    Similarity: Contains 1 MAGE domain


    MAGED4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAGD4_HUMAN, Q96JG8
    Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.
    Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate
    complex

    Phenotypes:
         1 GenomeRNAi human phenotype for MAGED4:

     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAGED4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAGED4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAGED4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAGED4

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAGED4:
    hsa-mir-335-5p (MIRT018197)

    Block miRNA regulation of human, mouse, rat MAGED4 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate MAGED4:
    hsa-miR-411* hsa-miR-141 hsa-miR-379* hsa-miR-891b hsa-miR-200a hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidMAGED4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAGED4
    Predesigned siRNA for gene silencing in human, mouse, rat MAGED4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAGED4

    Clone
    Products:
         
    OriGene clones in human, mouse for MAGED4 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAGED4 (NM_177535)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGED4
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAGED4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAGED4
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAGED4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGED4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAGED4
    Interactions:

        Search GeneGlobe Interaction Network for MAGED4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5 Interacting proteins for MAGED4 (Q96JG82, 3 ENSP000003647774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK8IP2Q133872, 3MINT-8262521 I2D: score=2 
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    PHYHIPQ925613I2D: score=4 
    CHMP243863I2D: score=1 
    RAE1P784063I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAGED4 (MAGD4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MAGED4 gene (4 alternative transcripts): 
    NM_001098800.2  NM_001272061.1  NM_001272062.1  NM_001272063.1  

    Unigene Clusters for MAGED4:

    Melanoma antigen family D, 4
    Hs.522650  [show with all ESTs], Hs.571729  [show with all ESTs]
    Unigene Representative Sequences: NM_001242362, NM_001272061
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471932 ENST00000459685 ENST00000375626 ENST00000477634 ENST00000498483
    ENST00000467526 ENST00000474812 ENST00000479281 ENST00000497416 ENST00000497348
    ENST00000416960(uc004dpz.3 uc004dpx.3 uc004dpw.3 uc004dpy.3 uc004dqa.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAGED4 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate MAGED4:
    hsa-miR-411* hsa-miR-141 hsa-miR-379* hsa-miR-891b hsa-miR-200a hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidMAGED4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAGED4
    Predesigned siRNA for gene silencing in human, mouse, rat MAGED4
    Clone
    Products:
         
    OriGene clones in human, mouse for MAGED4 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MAGED4 (NM_177535)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGED4
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAGED4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MAGED4
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MAGED4
      QuantiTect SYBR Green Assays in human, mouse, rat MAGED4
      QuantiFast Probe-based Assays in human, mouse, rat MAGED4

    Additional mRNA sequence: AK289458.1 

    Selected DOTS entries (see all 26):

    DT.100681454  DT.75111770  DT.100816309  DT.92430356  DT.100816300  DT.100665895  DT.40107206  DT.100816302 
    DT.100816303  DT.121302806  DT.121302697  DT.100808063  DT.121302770  DT.100816294  DT.102825067  DT.121318314 
    DT.95301976  DT.100816308  DT.100840251  DT.121302698  DT.121318307  DT.100799336  DT.121302692  DT.121318299 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MAGED4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAGED4 Expression
    About this image

    MAGED4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAGED4 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.522650 Hs.571729

    UniProtKB/Swiss-Prot: MAGD4_HUMAN, Q96JG8
    Tissue specificity: Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are
    specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples

        Custom PCR Arrays for MAGED4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MAGED4
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MAGED4
    QuantiTect SYBR Green Assays in human, mouse, rat MAGED4
    QuantiFast Probe-based Assays in human, mouse, rat MAGED4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGED4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for MAGED4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia LOC4809261 melanoma-associated antigen D4-like 90.23(n)
    89.86(a)
      480926  XM_005641366.1  XP_005641423.1 
    chicken
    (Gallus gallus)
    Aves MAGE6
    Gallus gallus necdin-like 2 (NDNL2), mRNA.
    40(a)
    1 → many
    JH376257.1(2550-4829)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    37(a)
    1 → many
    1(205667349-205679701)
    zebrafish
    (Danio rerio)
    Actinopterygii ndnl26
    necdin-like 2
    36(a)
    1 → many
    23(13012414-13025121) ENSDARG00000058212


    ENSEMBL Gene Tree for MAGED4 (if available)
    TreeFam Gene Tree for MAGED4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MAGED4 gene
    MAGED4B1 2  MAGEA32  MAGEC22  NDN2  MAGEB22  MAGEA9B2  MAGEB32  MAGEB52  
    MAGEA42  MAGEA12  MAGEB162  MAGEB182  MAGEA102  MAGEB12  MAGEB42  MAGEC12  
    MAGEA2B2  MAGEA82  MAGEB62  MAGED22  MAGEA122  MAGEL22  TRO2  MAGEA92  
    NDNL22  MAGEB172  MAGEA112  MAGEB102  MAGEA62  MAGED12  MAGEA22  MAGEF12  
    Selected SIMAP similar genes for MAGED4 using alignment to 1 protein entry:     MAGD4_HUMAN(see all similar genes):
    MAGED4B    MAGEH1    TRO    MAGEA8    MAGEB2    MAGEA3
    MAGEA12    MAGEA6    MAGEF1    MAGED2    MAGEB3    MAGEC4
    NDNL2    MAGEB4    MAGEA4    MAGEA1    MAGEA9    MAGEA9B

    MAGED4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MAGED4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516643CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MAGED4
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGED4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 300702    OMIM disorders: --

    3 diseases for MAGED4:    About MalaCards
    melanoma    renal cell carcinoma    lung cancer


    MAGED4 for disorders           About GeneDecksing


    Export disorders for MAGED4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MAGED4 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with MAGED4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma. (PubMed id 11406556)1, 2, 3 Sasaki M.... Ikenaka K. (Cancer Res. 2001)
    2. Structural characterization and chromosomal localization of the MAGE- E1 gene. (PubMed id 11602350)1, 2 Kawano Y....Ikenaka K. (Gene 2001)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR). (PubMed id 22544753)1 Agrawal P....Hughes R.E. (J. Biol. Chem. 2012)
    7. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PubMed id 20864041)2 Doyle J.M.... Potts P.R. (Mol. Cell 2010)
    8. Expression of MAGE-D4, a novel MAGE family antigen, is correlated with tumor-cell proliferation of non-small cell lung cancer. (PubMed id 16225959)1 Ito S....Tanaka F. (Lung Cancer 2006)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    10. MAGED4-expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue. (PubMed id 16082191)2 Kraemer B.F....Stevanovic S. (Cancer Biol. Ther. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 728239 HGNC: 23793 Ensembl:ENSG00000154545 euGenes: HUgn728239 ECgene: MAGED4
    H-InvDB: MAGED4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1859

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MAGED4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGED4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MAGED4 gene:
    Search GeneIP for patents involving MAGED4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MAGED4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MAGED4  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAGED4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAGED4   OriGene Custom Protein Services for MAGED4  

     
     
     Block miRNA regulation of human, mouse, rat MAGED4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MAGED4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGED4 Predesigned siRNA for gene silencing in human, mouse, rat MAGED4
     QuantiFast Probe-based Assays in human, mouse, rat MAGED4 QuantiTect SYBR Green Assays in human, mouse, rat MAGED4
     Custom PCR Arrays for MAGED4 Search Chromatin IP Primers for MAGED4
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MAGED4 Search GeneGlobe Interaction Network for MAGED4
     Regulatory tfbs in MAGED4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MAGED4 GenScript cDNA clones with any tag delivered in your preferred vector for MAGED4
     GenScript Custom Assay Services for MAGED4 GenScript Custom overexpressing Cell Line Services for MAGED4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MAGED4 (MAGD4)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Search for Antibodies for MAGED4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MAGED4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MAGED4
     Antibodies for MAGED4
     ELISAs for MAGED4
     CLIAs for MAGED4



     Browse ESI BIO Cell Lines and PureStem Progenitors for MAGED4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGED4
     SwitchGear 3'UTR luciferase reporter plasmids for MAGED4
     SwitchGear Promoter luciferase reporter plasmids for MAGED4
     Search ThermoFisher Antibodies for MAGED4
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAGED4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAGED4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAGED4
     LSBio Antibodies in human, mouse, rat for MAGED4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAGED4 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4