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Aliases for MAGED4 Gene

Aliases for MAGED4 Gene

  • Melanoma Antigen Family D4 2 3
  • MAGEE1 3 4 6
  • MAGE-D4 Antigen 3 4
  • MAGE-E1 Antigen 3 4
  • KIAA1859 4 6
  • Melanoma-Associated Antigen D4 3
  • Melanoma Antigen Family D, 4 3
  • MAGE-E1 3
  • MAGED4A 4
  • MAGE1 3

External Ids for MAGED4 Gene

Previous GeneCards Identifiers for MAGED4 Gene

  • GC0XP049889
  • GC0XP050579
  • GC0XM050721
  • GC0XM051637
  • GC0XM051821
  • GC0XP051949
  • GC0XP051952
  • GC0XP051927

Summaries for MAGED4 Gene

GeneCards Summary for MAGED4 Gene

MAGED4 (Melanoma Antigen Family D4) is a Protein Coding gene. An important paralog of this gene is MAGED1.

UniProtKB/Swiss-Prot for MAGED4 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGED4 Gene

Genomics for MAGED4 Gene

Regulatory Elements for MAGED4 Gene

Genomic Location for MAGED4 Gene

52,184,823 bp from pter
52,192,268 bp from pter
7,446 bases
Plus strand

Genomic View for MAGED4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGED4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGED4 Gene

Proteins for MAGED4 Gene

  • Protein details for MAGED4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen D4
    Protein Accession:
    Secondary Accessions:
    • A8K093
    • Q5HYN6
    • Q8WXW4
    • Q9BQ84
    • Q9BVH1
    • Q9BYH3
    • Q9BYH4
    • Q9H217

    Protein attributes for MAGED4 Gene

    741 amino acids
    Molecular mass:
    81378 Da
    Quaternary structure:
    • Interacts with TRIM27.
    • Sequence=AAH01207.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL50032.1; Type=Frameshift; Positions=186, 219; Evidence={ECO:0000305}; Sequence=BAB47488.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAGED4 Gene


neXtProt entry for MAGED4 Gene

Proteomics data for MAGED4 Gene at MOPED

Post-translational modifications for MAGED4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGED4 Gene

No data available for DME Specific Peptides for MAGED4 Gene

Domains for MAGED4 Gene

Protein Domains for MAGED4 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MAGE domain.
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGED4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MAGED4 Gene

Function for MAGED4 Gene

Molecular function for MAGED4 Gene

UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Phenotypes for MAGED4 Gene

GenomeRNAi human phenotypes for MAGED4:
genes like me logo Genes that share phenotypes with MAGED4: view

Animal Model Products

CRISPR Products

miRNA for MAGED4 Gene

miRTarBase miRNAs that target MAGED4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAGED4 Gene

Localization for MAGED4 Gene

Subcellular locations from

Jensen Localization Image for MAGED4 Gene COMPARTMENTS Subcellular localization image for MAGED4 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGED4 Gene

Pathways for MAGED4 Gene

SuperPathways for MAGED4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGED4 Gene


No data available for Pathways by source for MAGED4 Gene

Transcripts for MAGED4 Gene

mRNA/cDNA for MAGED4 Gene

(4) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGED4 Gene

Melanoma antigen family D, 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGED4 Gene

No ASD Table

Relevant External Links for MAGED4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGED4 Gene

mRNA expression in normal human tissues for MAGED4 Gene

mRNA differential expression in normal tissues according to GTEx for MAGED4 Gene

This gene is overexpressed in Brain - Hypothalamus (10.7) and Brain - Amygdala (5.0).

Protein differential expression in normal tissues for MAGED4 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (65.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGED4 Gene

SOURCE GeneReport for Unigene cluster for MAGED4 Gene Hs.522650

mRNA Expression by UniProt/SwissProt for MAGED4 Gene

Tissue specificity: Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples.
genes like me logo Genes that share expressions with MAGED4: view

Expression partners for MAGED4 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGED4 Gene

Orthologs for MAGED4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAGED4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAGED4B 35
  • 88.48 (n)
  • 86.72 (a)
-- 36
  • 86 (a)
(Canis familiaris)
Mammalia LOC480926 35
  • 90.23 (n)
  • 89.86 (a)
-- 36
  • 90 (a)
(Pan troglodytes)
Mammalia LOC465643 35
  • 99.81 (n)
  • 99.72 (a)
-- 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
-- 36
  • 31 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
(Gallus gallus)
Aves MAGE 36
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
(Danio rerio)
Actinopterygii ndnl2 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for MAGED4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAGED4 Gene

Gene Tree for MAGED4 (if available)
Gene Tree for MAGED4 (if available)

Paralogs for MAGED4 Gene

genes like me logo Genes that share paralogs with MAGED4: view

Variants for MAGED4 Gene

Sequence variations from dbSNP and Humsavar for MAGED4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs112352914 -- 52,191,946(+) GGGGC(C/G)CTGGG intron-variant
rs201653231 -- 52,186,117(+) CCAGG(C/T)CTTCG reference, synonymous-codon
rs368363830 -- 52,192,078(+) GCAGC(A/G)ATCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAGED4 Gene

Variant ID Type Subtype PubMed ID
nsv516643 CNV Gain 19592680

Relevant External Links for MAGED4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGED4 Gene

Disorders for MAGED4 Gene

No disorders were found for MAGED4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MAGED4 Gene

Publications for MAGED4 Gene

  1. MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma. (PMID: 11406556) Sasaki M. … Ikenaka K. (Cancer Res. 2001) 2 3 4
  2. Structural characterization and chromosomal localization of the MAGE- E1 gene. (PMID: 11602350) Kawano Y. … Ikenaka K. (Gene 2001) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3
  5. Expression of MAGE-D4, a novel MAGE family antigen, is correlated with tumor-cell proliferation of non-small cell lung cancer. (PMID: 16225959) Ito S. … Tanaka F. (Lung Cancer 2006) 3

Products for MAGED4 Gene

Sources for MAGED4 Gene

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