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Aliases & Descriptions for MAGED2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases 11B6 1 , 2 , 3 BCG-1 3 BCG1 1 , 2 , 3 HCA10 1 , 2 JCL-1 1 , 2 MAGE-D 3 MAGE-D2 1 , 2 MAGED 1 , 2 , 5 MGC8386 1 , 2 OTTHUMP00000023381 2 OTTHUMP00000023382 2
Descriptions Breast cancer-associated gene 1 protein 3 Hepatocellular carcinoma-associated protein JCL-1 3 MAGE-D2 antigen 3 breast cancer associated gene 1 2 hepatocellular carcinoma associated protein 2 hepatocellular carcinoma-associated protein HCA10 2 melanoma antigen family D, 2 2 melanoma-associated antigen D2 2
Search outside databases for aliases for MAGED2 genePrevious GC identifers: GC0XP051686 GC0XP052772 GC0XP053439 GC0XP053800 GC0XP054717
Summaries for MAGED2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for MAGED2 : This gene is a member of the MAGED gene family. While the MAGEA and MAGEB genes are silent innormal tissues with the exception of testis and placenta, the MAGED genes are expressedubiquitously. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, ahot spot for X-linked mental retardation (XLMR). Multiple alternatively spliced transcriptvariants have been found for this gene, however, the full length nature of some variants has notbeen defined. [provided by RefSeq] Gene Wiki entry for MAGED2
Genomic Location for MAGED2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MAGED2 gene Entrez Gene cytogenetic band: Xp11.2 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.2 MAGED2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP054850:
(about GC identifiers )
Start:
54,850,757 bp from pter
End:
54,859,170 bp from pter
Size:
8,414 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000023.9 NT_011630.14 Proteins for MAGED2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: MAGD2_HUMAN, Q9UNF1 (See
protein sequence )Recommended Name: Melanoma-associated antigen D2 Size : 606 amino acids; 64954 Da
Secondary accessions : A6NMX0 O76058 Q5BJF3 Q8NAL6 Q9H218 Q9P0U9 Q9UM52Alternative splicing : 2 isoforms : Q9UNF1-1 Q9UNF1-2
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_055414.2 NP_803182.1 NP_957516.1 ENSEMBL proteins: ENSP00000364198 ENSP00000364200 ENSP00000364209 ENSP00000336962 ENSP00000364193 ENSP00000340290 ENSP00000218439 ENSP00000379526 ENSP00000364202 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for MAGED2: Assays for MAGED2:
Protein
Domains/ Families for MAGED2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UNF1 ProtoNet protein and cluster: Q9UNF1
1 Blocks protein family : IPB002190 MAGE protein UniProtKB/Swiss-Prot: MAGD2_HUMAN, Q9UNF1 Similarity : Contains 1 MAGE domain
Gene Function for MAGED2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_014599 Applied Biosystems Silencer ® siRNAs for MAGED2 Sigma-Aldrich siRNA for MAGED2 Sigma-Aldrich shRNA for MAGED2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_014599                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_014599                                  untagged cDNA clones in CMV expression vector (see all 5 ): AK091003  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_177433 Pathways & Interactions for MAGED2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for MAGED2 4 Interacting proteins for MAGED2 (ENSP00000364209 3 Q9UNF1 2 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for MAGED2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for MAGED2
Transcripts for MAGED2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_014599 Sigma-Aldrich siRNA for MAGED2 Sigma-Aldrich shRNA for MAGED2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_014599 NM_177433 NM_201222
REFSEQ mRNAs for MAGED2 gene (3 alternative transcripts): NM_014599.4 NM_177433.1 NM_201222.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014599 NM_177433 NM_201222
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_014599                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_014599                                  untagged cDNA clones in CMV expression vector (see all 5 ): AK091003  
Additional cDNA sequence: AF126181.1 AF128527.1 AF128528.1 AF148815.1 AF320907.1 AJ293618.1 AK092463.1 AK098645.1 AK297910.1 AK301599.1 AK301821.1 BC000304.2 BC091503.1 BC107040.1 BX647995.1 CR595215.1 CR597524.1 CR605686.1 CR606543.1 CR624805.1 U92544.1
24/30 DOTS entries (see all 30
): DT.450043 DT.100042116 DT.92044994 DT.92464652 DT.87079441 DT.92464648 DT.100681955 DT.100848601 DT.40288367 DT.100681934 DT.95186940 DT.87079444 DT.95186927 DT.100875514 DT.99983002 DT.100042128 DT.100681933 DT.100867368 DT.100681946 DT.102835893 DT.95186923 DT.100033072 DT.100042122 DT.100681971
24/1068 AceView cDNA sequences (see all 1068
):BM846856 AA176338 CA448962 AA643888 BE383843 BM694110 CB305571 AI564907 CF131211 CA447098 BU556549 AA613956 BM550206 AI306585 NM_201222 T30710 BU556568 BM980484 BQ720755 BF689822 BF434364 AI669857 AI369794 CR606543
highest scoring ESTs for MAGED2 :AI934895 AA039316 AA081759 AA101569 AA113973 AA113981 AA115167 AA166897 AA172257 AA176356
Unigene Cluster for MAGED2: Melanoma antigen family D, 2 Hs.522665 [show with all ESTs ] Unigene Representative Sequence: AK092463 GeneLoc Exon Structure 5/15 Alternative Splicing Database (ASD) splice patterns (SP) for MAGED2 (see all 15
) ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ SP1 :             -         -   -   -             -   -           -     SP2 :       -   -   -   -                                     -     SP3 :             -                                     -     SP4 :                                                 -     SP5 :       -   -   -   -     -   -   -   -   -   -                          
ExUns: 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b SP1 :     -   -             SP2 :     -   -             SP3 :     -   -             SP4 :     -   -             SP5 :                  
About this scheme ECgene alternative splicing isoforms for MAGED2 9 Ensembl transcripts including schematic representations : ENST00000375058
ENST00000375060
ENST00000375068
ENST00000347546
ENST00000375053
ENST00000343474
ENST00000218439
ENST00000396224
ENST00000375062
Expression for MAGED2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MAGED2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MAGED2 1 / 2 / 3
7 probe-sets matching MAGED2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AATGGAAATCSOURCE GeneReport for Unigene cluster: Hs.522665 Expression variation in blood from EXPOLDB for MAGED2
UniProtKB/Swiss-Prot: MAGD2_HUMAN, Q9UNF1 Tissue specificity : Widely expressed in normal tissues
Orthologs for MAGED2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for MAGED2 gene from 5 species
About this table Species with no ortholog for MAGED2 ENSEMBL Gene Tree for MAGED2 Paralogs for MAGED2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MAGED2 gene MAGED4B 2 LOC100132401 2 MAGED4 2 MAGED1 2 TRO 2
SNPs/Variants for MAGED2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MAGED2 (up to first 250kb)
Disorders & Mutations for MAGED2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 300470 Human Genome Epidemiology Navigator: MAGED2 (1 document)
Medical News for MAGED2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MAGED2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/20 PubMed articles for MAGED2 gene (see all 20
): Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) The DNA sequence of the human X chromosome. (PubMed id 15772651) 3, 4 Ross M.T.... Bentley D.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935) 3, 4 Beausoleil S.A....Gygi S.P. (2004) Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues. (PubMed id 11856887) 3, 4 Langnaese K.... Wieacker P. (2001) Isolation of genes overexpressed in freshly isolated breast cancer specimens. (PubMed id 10752678) 3, 4 Kurt R.A.... Schoof D.D. (2000) A new MAGE gene with ubiquitous expression does not code for known MAGE antigens recognized by T cells. (PubMed id 10463614) 3, 4 Lucas S.... Boon T. (1999) Identification of a novel MAGE D2 antisense RNA transcript in human tissues. (PubMed id 15465002) 1, 3 Harper R....Wu R. (2004) Comparative expression analysis of the MAGED genes during embryogenesis and brain development. (PubMed id 15162511) 1, 3 Bertrand M....De Backer O. (2004)
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Genome Databases showing MAGED2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing MAGED2
(According to HUGE )
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Specialized Databases showing MAGED2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for MAGED2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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