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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGED2 Gene

protein-coding   GIFtS: 56
GCID: GC0XP054834

melanoma antigen family D, 2

 Explore 6 diseases affiliated with
MAGED2 via our new
 Human Malady Compendium 
Biological research products
for MAGED2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Melanoma Antigen Family D, 21 2     Hepatocellular Carcinoma-Associated Protein JCL-12 3
11B61 2 3     BCG-12 3
BCG11 2 3     MAGE-D2 Antigen2 3
MAGED1 2 5     MGC83861
HCA101 2     Breast Cancer Associated Gene 12
JCL-11 2     Hepatocellular Carcinoma Associated Protein2
MAGE-D21 2     Hepatocellular Carcinoma-Associated Protein HCA102
Breast Cancer-Associated Gene 1 Protein2 3     Melanoma-Associated Antigen D22

External Ids:    HGNC: 163531   Entrez Gene: 109162   Ensembl: ENSG000001023167   OMIM: 3004705   UniProtKB: Q9UNF13   

Export aliases for MAGED2 gene to outside databases

Previous GC identifers: GC0XP051686 GC0XP052772 GC0XP053439 GC0XP053800 GC0XP054717 GC0XP054850 GC0XP051883


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAGED2:
This gene is a member of the MAGED gene family. While the MAGEA and MAGEB genes are silent in normal tissues with the
exception of testis and placenta, the MAGED genes are expressed ubiquitously. The MAGED genes are clustered on
chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked mental retardation (XLMR). Multiple
alternatively spliced transcript variants have been found for this gene, however, the full length nature of some
variants has not been defined. (provided by RefSeq, Jul 2008)

Gene Wiki entry for MAGED2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011630.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGED2 gene promoter:
         p53   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAGED2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAGED2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGED2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.2   Ensembl cytogenetic band:  Xp11.21   HGNC cytogenetic band: Xp11.2

MAGED2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGED2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP054834:  view genomic region     (about GC identifiers)

Start:
54,834,032 bp from pter      End:
54,842,445 bp from pter
Size:
8,414 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MAGD2_HUMAN, Q9UNF1 (See protein sequence)
Recommended Name: Melanoma-associated antigen D2  
Size: 606 amino acids; 64954 Da
Secondary accessions: A6NMX0 O76058 Q5BJF3 Q8NAL6 Q9H218 Q9P0U9 Q9UM52
Alternative splicing: 2 isoforms:  Q9UNF1-1   Q9UNF1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAGED2: NX_Q9UNF1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UNF1

  • MAGED2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_055414.2  NP_803182.1  NP_957516.1  

    ENSEMBL proteins: 
     ENSP00000364209   ENSP00000336962   ENSP00000364198   ENSP00000364200   ENSP00000364193  
     ENSP00000340290   ENSP00000364202   ENSP00000218439   ENSP00000379526  

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    Uscn Proteins for MAGED2


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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MAGED2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry Q9UNF1

    ProtoNet protein and cluster: Q9UNF1

    1 Blocks protein family: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGD2_HUMAN, Q9UNF1
    Similarity: Contains 1 MAGE domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-647 hsa-miR-3121-3p hsa-miR-548u hsa-miR-604 hsa-miR-3605-5p
    SwitchGear 3'UTR luciferase reporter plasmidMAGED2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGED2

    1 GenomeRNAi human phenotype for MAGED2:
     Decreased nuclei size in G2M 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAGED2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/570 Interacting proteins for MAGED2 (Q9UNF12, 3 ENSP000002184394) via UniProtKB, MINT, STRING, and/or I2D (see all 570)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1A1P681042, 3MINT-7945693 I2D: score=3 
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    TCEA2Q155603, ENSP000003435154I2D: score=1 STRING: ENSP00000343515
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAGED2
    Search CenterWatch for drugs/clinical trials and news about MAGED2 / MAGD2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAGED2 gene (3 alternative transcripts): 
    NM_014599.4  NM_177433.1  NM_201222.1  

    Unigene Cluster for MAGED2:

    Melanoma antigen family D, 2
    Hs.522665  [show with all ESTs]
    Unigene Representative Sequence: AK092463
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375068(uc004dtk.1) ENST00000347546(uc004dto.1) ENST00000463787
    ENST00000375058(uc004dtl.1) ENST00000375060(uc004dtm.1) ENST00000485483
    ENST00000497484 ENST00000487482 ENST00000487463 ENST00000375053 ENST00000343474
    ENST00000375062 ENST00000218439 ENST00000396224(uc004dtn.1)

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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate MAGED2:
    hsa-miR-647 hsa-miR-3121-3p hsa-miR-548u hsa-miR-604 hsa-miR-3605-5p
    SwitchGear 3'UTR luciferase reporter plasmidMAGED2 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF126181.1 AF128527.1 AF128528.1 AF148815.1 AF320907.1 AJ293618.1 AK092463.1 AK098645.1 
    AK297910.1 AK301599.1 AK301821.1 BC000304.2 BC091503.1 BC107040.1 BX647995.1 U92544.1 

    24/30 DOTS entries (see all 30):

    DT.450043  DT.100042116  DT.92044994  DT.92464652  DT.87079441  DT.92464648  DT.100681955  DT.100848601 
    DT.100681934  DT.40288367  DT.95186940  DT.87079444  DT.95186927  DT.100875514  DT.99983002  DT.100042128 
    DT.100681933  DT.100867368  DT.100681946  DT.102835893  DT.121321810  DT.121632604  DT.95186923  DT.100033072 

    24/1068 AceView cDNA sequences (see all 1068):

    BQ683743 BU146958 BX385171 BQ677764 BQ436316 AA604206 BM014129 BF222395 
    AI139827 AL138163 BG059808 BQ679904 BM474835 BE276801 CD109209 BQ581546 
    BU556568 NM_177433 AI129909 BM848628 T35190 BQ575270 BM975640 CF132135 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for MAGED2 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^
    SP1:                                      -                       -     -     -                                   -     -                             -         
    SP2:                    -     -     -     -                                                                                                           -         
    SP3:                                      -                                                                                                           -         
    SP4:                                                                                                                                                  -         
    SP5:                    -     -     -     -           -     -     -     -     -     -                                                                           

    ExUns: 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:              -     -                                 
    SP2:              -     -                                 
    SP3:              -     -                                 
    SP4:              -     -                                 
    SP5:                                                      


    ECgene alternative splicing isoforms for MAGED2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGED2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATGGAAATC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MAGED2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAGED2

    SOURCE GeneReport for Unigene cluster: Hs.522665

    UniProtKB/Swiss-Prot: MAGD2_HUMAN, Q9UNF1
    Tissue specificity: Widely expressed in normal tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGED2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAGED2 gene from 3/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    44(a)
    1 → many
    1(205669616-205678308)
    zebrafish
    (Danio rerio)
    Actinopterygii ndnl26
    necdin-like 2
    39(a)
    1 → many
    23(13012414-13025121)
    fruit fly
    (Drosophila melanogaster)
    Insecta MAGE6
    MAGE
    22(a)
    1 → many
    3R(2979960-2980898)


    ENSEMBL Gene Tree for MAGED2 (if available)
    TreeFam Gene Tree for MAGED2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGED2 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB42  MAGEB12  MAGEC12  MAGED42  
    MAGEA82  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGEE12  MAGED12  
    MAGEA22  MAGEC32  MAGEA32  NDN2  MAGEB22  MAGEB32  MAGED4B2  MAGEE22  
    MAGEA42  MAGEA12  MAGEA102  MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  
    MAGEA112  NDNL22  MAGEF12  
    18/35 SIMAP similar genes for MAGED2 using alignment to 4 protein entries:     MAGD2_HUMAN (see all proteins) (see all similar genes):
    MAGED1    TRO    MAGEH1    MAGEC1    MAGEC4    NDNL2
    MAGEA10    MAGEA1    MAGEA11    MAGEA8    MAGEC3    MAGEA9
    MAGEA9B    MAGEB5    MAGED4    MAGED4B    NDN    MAGEA2

    MAGED2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/136 NCBI SNPs in MAGED2 are shown (see all 136    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842358761,2
    --54832264(+) GACACC/TCCCCT 1 -- us2k10--------
    rs1882898921,2
    --54832367(+) TGCCAC/TCACTC 1 -- us2k10--------
    rs70609601,2
    C,--54832446(+) gacaaC/Gaccta 1 -- us2k10--------
    rs46125171,2
    C,H--54832519(+) CCTAGA/CATTCT 1 -- us2k16Minor allele frequency- C:0.00NS EA NA 422
    rs1922307621,2
    --54832615(+) GGGTGC/GGGAAT 1 -- us2k10--------
    rs1838547841,2
    --54832658(+) CTATGG/TCTAGT 1 -- us2k10--------
    rs1112793551,2
    C,--54833164(+) TTAGTC/TTGCAC 2 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1126892231,2
    C,--54833220(+) GAATCT/CGTATA 2 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1381478871,2
    C,--54833301(+) AACGGA/GGTTTG 2 -- us2k10--------
    rs1428123971,2
    --54833352(+) TCCAGG/TTGTGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAGED2 (54834032 - 54842445 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MAGED2
         1 CNV: 23256
    Locus Specific Mutation Databases (LSDB): MAGED2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGED2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGED2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MAGED2 for disorders           About GeneDecksing

    OMIM gene information: 300470    OMIM disorders: --

    6 diseases for MAGED2:    About MalaCards
    hepatocellular carcinoma    breast cancer    carcinoma    melanoma
    hepatitis b    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: MAGED2 (3 documents)

    Export disorders for MAGED2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAGED2 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with MAGED2)
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    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues. (PubMed id 11856887)1, 2 Langnaese K.... Wieacker P. (2001)
    6. Isolation of genes overexpressed in freshly isolated breast cancer specimens. (PubMed id 10752678)1, 2 Kurt R.A.... Schoof D.D. (2000)
    7. A new MAGE gene with ubiquitous expression does not code for known MAGE antigens recognized by T cells. (PubMed id 10463614)1, 2 Lucas S.... Boon T. (1999)
    8. Identification of a novel MAGE D2 antisense RNA transcript in human tissues. (PubMed id 15465002)1, 9 Harper R....Wu R. (2004)
    9. Comparative expression analysis of the MAGED genes during embryogenesis and brain development. (PubMed id 15162511)1, 9 Bertrand M....De Backer O. (2004)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10916 HGNC: 16353 AceView: MAGED2 Ensembl:ENSG00000102316 euGenes: HUgn10916
    ECgene: MAGED2 H-InvDB: MAGED2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAGED2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGED2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAGED2 gene:
    Search GeneIP for patents involving MAGED2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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