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Aliases for MAGED1 Gene

Aliases for MAGED1 Gene

  • Melanoma Antigen Family D1 2 3
  • Neurotrophin Receptor-Interacting MAGE Homolog 3 4
  • MAGE Tumor Antigen CCF 3 4
  • MAGE-D1 Antigen 3 4
  • NRAGE 3 4
  • Melanoma Antigen Family D, 1 3
  • DLXIN-1 3

External Ids for MAGED1 Gene

Previous GeneCards Identifiers for MAGED1 Gene

  • GC0XU990274
  • GC0XP049684
  • GC0XP050230
  • GC0XP050553
  • GC0XP051469
  • GC0XP051562
  • GC0XP048983

Summaries for MAGED1 Gene

Entrez Gene Summary for MAGED1 Gene

  • This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGED1 Gene

MAGED1 (Melanoma Antigen Family D1) is a Protein Coding gene. Diseases associated with MAGED1 include keratosis, seborrheic, somatic and melanoma. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is MAGEB4.

UniProtKB/Swiss-Prot for MAGED1 Gene

  • Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.

Gene Wiki entry for MAGED1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGED1 Gene

Genomics for MAGED1 Gene

Regulatory Elements for MAGED1 Gene

Genomic Location for MAGED1 Gene

Chromosome:
X
Start:
51,803,007 bp from pter
End:
51,902,357 bp from pter
Size:
99,351 bases
Orientation:
Plus strand

Genomic View for MAGED1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGED1 Gene

Proteins for MAGED1 Gene

  • Protein details for MAGED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5V3-MAGD1_HUMAN
    Recommended name:
    Melanoma-associated antigen D1
    Protein Accession:
    Q9Y5V3
    Secondary Accessions:
    • Q5VSH6
    • Q8IZ84
    • Q8WY92
    • Q9H352
    • Q9HBT4
    • Q9UF36

    Protein attributes for MAGED1 Gene

    Size:
    778 amino acids
    Molecular mass:
    86161 Da
    Quaternary structure:
    • Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA.
    SequenceCaution:
    • Sequence=AAD31421.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG35551.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAGED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGED1 Gene

Proteomics data for MAGED1 Gene at MOPED

Post-translational modifications for MAGED1 Gene

  • Ubiquitination at Lys 86, Lys 101, Lys 141, Lys 154, Lys 178, Lys 182, Lys 189, Lys 251, Lys 493, Lys 522, Lys 523, Lys 605, Lys 613, Lys 615, and Lys 656
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGED1 Gene

Antibody Products

No data available for DME Specific Peptides for MAGED1 Gene

Domains & Families for MAGED1 Gene

Gene Families for MAGED1 Gene

Protein Domains for MAGED1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGED1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5V3

UniProtKB/Swiss-Prot:

MAGD1_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGED1: view

Function for MAGED1 Gene

Molecular function for MAGED1 Gene

GENATLAS Biochemistry:
putative melanoma antigen,family D,member 1,expressed in breast,colon,brain,fetal tissue,tumoral cell (breast,lung,prostate,Wilms),not recognized by T cells but expressed only in tumor and germ-line cells
UniProtKB/Swiss-Prot Function:
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.

Gene Ontology (GO) - Molecular Function for MAGED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IEA --
GO:0005515 protein binding IPI 15930293
genes like me logo Genes that share ontologies with MAGED1: view
genes like me logo Genes that share phenotypes with MAGED1: view

Animal Models for MAGED1 Gene

MGI Knock Outs for MAGED1:

Animal Model Products

CRISPR Products

miRNA for MAGED1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MAGED1 Gene

Localization for MAGED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGED1 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGED1 Gene COMPARTMENTS Subcellular localization image for MAGED1 gene
Compartment Confidence
nucleus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MAGED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISS --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0043234 protein complex IDA 15930293
genes like me logo Genes that share ontologies with MAGED1: view

Pathways & Interactions for MAGED1 Gene

genes like me logo Genes that share pathways with MAGED1: view

Pathways by source for MAGED1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for MAGED1 Gene

Activates:

Gene Ontology (GO) - Biological Process for MAGED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 15930293
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006915 apoptotic process TAS --
GO:0012501 programmed cell death TAS --
GO:0032922 circadian regulation of gene expression ISS --
genes like me logo Genes that share ontologies with MAGED1: view

Drugs & Compounds for MAGED1 Gene

No Compound Related Data Available

Transcripts for MAGED1 Gene

Unigene Clusters for MAGED1 Gene

Melanoma antigen family D, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGED1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15
SP1: - - -
SP2: - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6:
SP7: -
SP8: - -
SP9:

Relevant External Links for MAGED1 Gene

GeneLoc Exon Structure for
MAGED1
ECgene alternative splicing isoforms for
MAGED1

Expression for MAGED1 Gene

mRNA expression in normal human tissues for MAGED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAGED1 Gene

This gene is overexpressed in Bone (47.2) and Heart (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGED1 Gene



SOURCE GeneReport for Unigene cluster for MAGED1 Gene Hs.5258

mRNA Expression by UniProt/SwissProt for MAGED1 Gene

Q9Y5V3-MAGD1_HUMAN
Tissue specificity: Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed
genes like me logo Genes that share expression patterns with MAGED1: view

Protein tissue co-expression partners for MAGED1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAGED1 Gene

Orthologs for MAGED1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAGED1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAGED1 35
  • 89.9 (n)
  • 91.6 (a)
MAGED1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAGED1 35
  • 91.16 (n)
  • 92.91 (a)
MAGED1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Maged1 35
  • 88.62 (n)
  • 88.84 (a)
Maged1 16
Maged1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAGED1 35
  • 99.72 (n)
  • 99.52 (a)
MAGED1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Maged1 35
  • 88.79 (n)
  • 89.4 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAGE 36
  • 41 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ndnl2 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for MAGED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAGED1 Gene

ENSEMBL:
Gene Tree for MAGED1 (if available)
TreeFam:
Gene Tree for MAGED1 (if available)

Paralogs for MAGED1 Gene

genes like me logo Genes that share paralogs with MAGED1: view

Variants for MAGED1 Gene

Sequence variations from dbSNP and Humsavar for MAGED1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs148317541 -- 51,824,891(+) TGTGT(-/TGTG)GTGTG intron-variant
rs148003180 -- 51,840,976(+) AATGG(C/T)ATTTC intron-variant
rs145367362 -- 51,806,164(+) AGACG(A/G)GGTTT intron-variant
rs144264968 -- 51,895,451(+) AAGGC(C/T)CAGAA reference, synonymous-codon
rs143297607 -- 51,824,712(+) GTGTG(-/GTGT)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGED1 Gene

Variant ID Type Subtype PubMed ID
nsv516643 CNV Gain 19592680
nsv6906 CNV Loss 18451855
esv2664331 CNV Deletion 23128226

Variation tolerance for MAGED1 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGED1 Gene

HapMap Linkage Disequilibrium report
MAGED1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGED1 Gene

Disorders for MAGED1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAGED1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
keratosis, seborrheic, somatic
  • seborrheic keratosis
melanoma
  • malignant melanoma
- elite association

Relevant External Links for MAGED1

Genetic Association Database (GAD)
MAGED1
Human Genome Epidemiology (HuGE) Navigator
MAGED1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGED1
genes like me logo Genes that share disorders with MAGED1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGED1 Gene

Publications for MAGED1 Gene

  1. Mapping of NRAGE domains reveals clues to cell viability in BMP signaling. (PMID: 19937275) Rochira J.A. … Verdi J.M. (Apoptosis 2010) 23 67
  2. A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway. (PMID: 20100315) Matluk N. … Verdi J.M. (BMC Biol. 2010) 23 67
  3. NRAGE is a negative regulator of nerve growth factor-stimulated neurite outgrowth in PC12 cells mediated through TrkA-ERK signaling. (PMID: 20127820) Feng Z. … Wen C. (J. Neurosci. Res. 2010) 23 67
  4. MAGE-D1 inhibits proliferation, migration and invasion of human breast cancer cells. (PMID: 19639218) Du Q. … Fang W.G. (Oncol. Rep. 2009) 23 67
  5. Melanoma-associated antigen family protein-D1 regulation of tumor cell migration, adhesion to endothelium, and actin structures reorganization in response to hypoxic stress. (PMID: 17453828) Shen W.G. … Su Q. (Cell Commun. Adhes. 2007) 23 67

Products for MAGED1 Gene

Sources for MAGED1 Gene

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