Aliases for MAGED1 Gene
External Ids for MAGED1 Gene
Previous GeneCards Identifiers for MAGED1 Gene
This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAGED1 Gene
MAGED1 (MAGE Family Member D1) is a Protein Coding gene. Diseases associated with MAGED1 include Melanoma and Keratosis, Seborrheic, Somatic. Among its related pathways are Signaling by GPCR and Neurotrophic factor-mediated Trk receptor signaling. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is MAGED4.
UniProtKB/Swiss-Prot for MAGED1 Gene
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.