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Aliases for MAGED1 Gene

Aliases for MAGED1 Gene

  • Melanoma Antigen Family D1 2 3
  • Neurotrophin Receptor-Interacting MAGE Homolog 3 4
  • MAGE Tumor Antigen CCF 3 4
  • MAGE-D1 Antigen 3 4
  • NRAGE 3 4
  • Melanoma-Associated Antigen D1 3
  • Melanoma Antigen Family D, 1 3
  • DLXIN-1 3

External Ids for MAGED1 Gene

Summaries for MAGED1 Gene

Entrez Gene Summary for MAGED1 Gene

  • This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGED1 Gene

MAGED1 (Melanoma Antigen Family D1) is a Protein Coding gene. Diseases associated with MAGED1 include melanoma. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is MAGEB4.

UniProtKB/Swiss-Prot for MAGED1 Gene

  • Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.

Gene Wiki entry for MAGED1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGED1 Gene

Genomics for MAGED1 Gene

Genomic Location for MAGED1 Gene

Start:
51,803,007 bp from pter
End:
51,902,357 bp from pter
Size:
99,351 bases
Orientation:
Plus strand

Genomic View for MAGED1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGED1 Gene

Regulatory Elements for MAGED1 Gene

Proteins for MAGED1 Gene

  • Protein details for MAGED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5V3-MAGD1_HUMAN
    Recommended name:
    Melanoma-associated antigen D1
    Protein Accession:
    Q9Y5V3
    Secondary Accessions:
    • Q5VSH6
    • Q8IZ84
    • Q8WY92
    • Q9H352
    • Q9HBT4
    • Q9UF36

    Protein attributes for MAGED1 Gene

    Size:
    778 amino acids
    Molecular mass:
    86161 Da
    Quaternary structure:
    • Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA.
    SequenceCaution:
    • Sequence=AAD31421.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG35551.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAGED1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGED1 Gene

Proteomics data for MAGED1 Gene at MOPED

Post-translational modifications for MAGED1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys86, Lys101, Lys141, Lys154, Lys178, Lys182, Lys189, Lys251, Lys480, Lys489, Lys493, Lys522, Lys523, Lys605, Lys613, Lys615, and Lys656

Other Protein References for MAGED1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGED1 Gene

Domains for MAGED1 Gene

Protein Domains for MAGED1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

MAGD1_HUMAN
Domain:
  • Contains 1 MAGE domain.:
    • Q9Y5V3
genes like me logo Genes that share domains with MAGED1: view

No data available for Gene Families for MAGED1 Gene

Function for MAGED1 Gene

Molecular function for MAGED1 Gene

GENATLAS Biochemistry: putative melanoma antigen,family D,member 1,expressed in breast,colon,brain,fetal tissue,tumoral cell (breast,lung,prostate,Wilms),not recognized by T cells but expressed only in tumor and germ-line cells
UniProtKB/Swiss-Prot Function: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.

Gene Ontology (GO) - Molecular Function for MAGED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IEA --
GO:0005515 protein binding IPI 15930293
genes like me logo Genes that share ontologies with MAGED1: view
genes like me logo Genes that share phenotypes with MAGED1: view

Animal Models for MAGED1 Gene

MGI Knock Outs for MAGED1:

miRNA for MAGED1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MAGED1 Gene

Localization for MAGED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGED1 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGED1 Gene COMPARTMENTS Subcellular localization image for MAGED1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MAGED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISS --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0043234 protein complex IDA 15930293
genes like me logo Genes that share ontologies with MAGED1: view

Pathways for MAGED1 Gene

genes like me logo Genes that share pathways with MAGED1: view

Pathways by source for MAGED1 Gene

Gene Ontology (GO) - Biological Process for MAGED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 15930293
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006915 apoptotic process TAS --
GO:0012501 programmed cell death TAS --
GO:0032922 circadian regulation of gene expression ISS --
genes like me logo Genes that share ontologies with MAGED1: view

Transcripts for MAGED1 Gene

Unigene Clusters for MAGED1 Gene

Melanoma antigen family D, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGED1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15
SP1: - - -
SP2: - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6:
SP7: -
SP8: - -
SP9:

Relevant External Links for MAGED1 Gene

GeneLoc Exon Structure for
MAGED1
ECgene alternative splicing isoforms for
MAGED1

Expression for MAGED1 Gene

mRNA expression in normal human tissues for MAGED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGED1 Gene

SOURCE GeneReport for Unigene cluster for MAGED1 Gene Hs.5258

mRNA Expression by UniProt/SwissProt for MAGED1 Gene

Q9Y5V3-MAGD1_HUMAN
Tissue specificity: Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed
genes like me logo Genes that share expressions with MAGED1: view

Orthologs for MAGED1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAGED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGED1 36
  • 99.72 (n)
  • 99.52 (a)
MAGED1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAGED1 36
  • 89.9 (n)
  • 91.6 (a)
MAGED1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAGED1 36
  • 91.16 (n)
  • 92.91 (a)
MAGED1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Maged1 36
  • 88.62 (n)
  • 88.84 (a)
Maged1 16
Maged1 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 43 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 40 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Maged1 36
  • 88.79 (n)
  • 89.4 (a)
chicken
(Gallus gallus)
Aves MAGE 37
  • 41 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ndnl2 37
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToMany
Species with no ortholog for MAGED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAGED1 Gene

ENSEMBL:
Gene Tree for MAGED1 (if available)
TreeFam:
Gene Tree for MAGED1 (if available)

Paralogs for MAGED1 Gene

genes like me logo Genes that share paralogs with MAGED1: view

Variants for MAGED1 Gene

Sequence variations from dbSNP and Humsavar for MAGED1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs893663 -- 51,853,483(-) ACAAT(A/G)AGCTG intron-variant
rs980344 -- 51,842,978(-) GTGGC(A/G)CATGC intron-variant
rs1048435 -- 51,872,630(+) AATGT(C/T)TTGGT intron-variant
rs1048437 -- 51,873,031(+) acttg(A/C)tttct intron-variant
rs1130004 -- 51,872,772(+) gacac(G/T)tctac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGED1 Gene

Variant ID Type Subtype PubMed ID
nsv516643 CNV Gain 19592680
nsv6906 CNV Loss 18451855
esv2664331 CNV Deletion 23128226

Relevant External Links for MAGED1 Gene

HapMap Linkage Disequilibrium report
MAGED1
Locus Specific Mutation Databases (LSDB)
MAGED1

Disorders for MAGED1 Gene

(1) MalaCards Diseases for MAGED1 Gene

Search for MAGED1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MAGED1 Gene

(2) Novoseek inferred disease relationships for MAGED1 Gene

Disease -log(P) Hits PubMed IDs
melanoma 32.8 2
tumors 0 2

Relevant External Links for MAGED1

Genetic Association Database (GAD)
MAGED1
Human Genome Epidemiology (HuGE) Navigator
MAGED1
genes like me logo Genes that share disorders with MAGED1: view

No data available for UniProtKB/Swiss-Prot for MAGED1 Gene

Publications for MAGED1 Gene

  1. NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor dependent apoptosis. (PMID: 10985348) Salehi A.H. … Barker P.A. (Neuron 2000) 3 4 23
  2. A new melanoma antigen-encoding gene subfamily in human chromosome X. (PMID: 11280991) Zhang C.G. … He F.C. (Yi Chuan Xue Bao 2001) 3 4 23
  3. hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation. (PMID: 15094062) Wen C.-J. … Li C.-J. (FEBS Lett. 2004) 3 4 23
  4. Identification of a new, unorthodox member of the MAGE gene family. (PMID: 10409427) Pold M. … Berenson J.R. (Genomics 1999) 2 3 4
  5. Comparative expression analysis of the MAGED genes during embryogenesis and brain development. (PMID: 15162511) Bertrand M. … De Backer O. (Dev. Dyn. 2004) 3 23

Products for MAGED1 Gene

Sources for MAGED1 Gene

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