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Aliases for MAGEC3 Gene

Aliases for MAGEC3 Gene

  • MAGE Family Member C3 2 3 5
  • Hepatocellular Carcinoma-Associated Antigen 2 3 4
  • Cancer/Testis Antigen Family 7, Member 2 2 3
  • Melanoma Antigen Family C3 2 3
  • Cancer/Testis Antigen 7.2 3 4
  • MAGE-C3 Antigen 3 4
  • CT7.2 3 4
  • HCA2 3 4
  • Hepatocellular Carcinoma-Associated Protein HCA2 3
  • MAGE Family Testis And Tumor-Specific Protein 3
  • Melanoma-Associated Antigen C3 3
  • Melanoma Antigen Family C, 3 3
  • MAGE-C3 3
  • MAGEC4 3

External Ids for MAGEC3 Gene

Previous GeneCards Identifiers for MAGEC3 Gene

  • GC0XP137783
  • GC0XP138859
  • GC0XP139619
  • GC0XP140651
  • GC0XP140753
  • GC0XP140926
  • GC0XP130029

Summaries for MAGEC3 Gene

Entrez Gene Summary for MAGEC3 Gene

  • This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues, except for testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on chromosome Xq26-q27. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEC3 Gene

MAGEC3 (MAGE Family Member C3) is a Protein Coding gene. An important paralog of this gene is MAGEC1.

Additional gene information for MAGEC3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEC3 Gene

Genomics for MAGEC3 Gene

Regulatory Elements for MAGEC3 Gene

Enhancers for MAGEC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH141404 0.9 Ensembl ENCODE 20.3 -432.2 -432242 3.2 PKNOX1 JUN CEBPB NR3C1 DPF2 EP300 JUND GATA3 MAFF RCOR1 MAGEC3 GC0XP141381 SPANXA2-OT1
GH0XH141816 0.3 FANTOM5 8.2 -21.9 -21940 0 MAGEC3 GC0XP141798
GH0XH141814 0.2 ENCODE 0.3 -23.3 -23337 1.4 GC0XP141798 MAGEC3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAGEC3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MAGEC3 Gene

Genomic Locations for MAGEC3 Gene
59,517 bases
Plus strand

Genomic View for MAGEC3 Gene

Genes around MAGEC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEC3 Gene

Proteins for MAGEC3 Gene

  • Protein details for MAGEC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen C3
    Protein Accession:
    Secondary Accessions:
    • Q3SYA7
    • Q5JZ43
    • Q9BZ80

    Protein attributes for MAGEC3 Gene

    643 amino acids
    Molecular mass:
    71909 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAGEC3 Gene


neXtProt entry for MAGEC3 Gene

Post-translational modifications for MAGEC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEC3 Gene

No data available for DME Specific Peptides for MAGEC3 Gene

Domains & Families for MAGEC3 Gene

Gene Families for MAGEC3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for MAGEC3 Gene


Suggested Antigen Peptide Sequences for MAGEC3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEC3: view

No data available for UniProtKB/Swiss-Prot for MAGEC3 Gene

Function for MAGEC3 Gene

genes like me logo Genes that share phenotypes with MAGEC3: view

miRNA for MAGEC3 Gene

miRTarBase miRNAs that target MAGEC3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEC3 Gene

Localization for MAGEC3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEC3 gene
Compartment Confidence
plasma membrane 3
cytosol 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MAGEC3 Gene

Pathways & Interactions for MAGEC3 Gene

SuperPathways for MAGEC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEC3 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAGEC3 Gene

Drugs & Compounds for MAGEC3 Gene

No Compound Related Data Available

Transcripts for MAGEC3 Gene

mRNA/cDNA for MAGEC3 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEC3 Gene

Melanoma antigen family C, 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: -
SP3: -

Relevant External Links for MAGEC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEC3 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEC3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.8).

Protein differential expression in normal tissues from HIPED for MAGEC3 Gene

This gene is overexpressed in Cervix (49.1) and Tlymphocyte (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEC3 Gene

Protein tissue co-expression partners for MAGEC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGEC3 Gene:


SOURCE GeneReport for Unigene cluster for MAGEC3 Gene:


mRNA Expression by UniProt/SwissProt for MAGEC3 Gene:

Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.
genes like me logo Genes that share expression patterns with MAGEC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEC3 Gene

Orthologs for MAGEC3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC741769 33
  • 93.88 (n)
(Canis familiaris)
Mammalia -- 34
  • 30 (a)
-- 34
  • 26 (a)
(Bos Taurus)
Mammalia MAGEC3 34
  • 26 (a)
Species where no ortholog for MAGEC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEC3 Gene

Gene Tree for MAGEC3 (if available)
Gene Tree for MAGEC3 (if available)

Paralogs for MAGEC3 Gene

genes like me logo Genes that share paralogs with MAGEC3: view

Variants for MAGEC3 Gene

Sequence variations from dbSNP and Humsavar for MAGEC3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000040476 -- 141,846,484(+) AGGAC(A/G)ATGAG intron-variant
rs1000121902 -- 141,885,757(+) ATCTG(C/G)AAATG intron-variant
rs1000240356 -- 141,841,640(+) ACTTA(A/G)TAGAC intron-variant
rs1000323586 -- 141,866,863(+) CACAC(A/G)CAATA intron-variant
rs1000324302 -- 141,850,307(+) ATACT(C/G)CAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEC3 Gene

Variant ID Type Subtype PubMed ID
nsv522089 CNV gain 19592680
nsv473071 CNV novel sequence insertion 20440878
esv3574880 CNV loss 25503493
esv3574879 CNV loss 25503493

Variation tolerance for MAGEC3 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEC3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEC3 Gene

Disorders for MAGEC3 Gene

Relevant External Links for MAGEC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAGEC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGEC3 Gene

Publications for MAGEC3 Gene

  1. MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PMID: 10861452) Lucas S … Boon T (International journal of cancer 2000) 2 3 4 60
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  3. Soluble adenylyl cyclase mediates hydrogen peroxide-induced changes in epithelial barrier function. (PMID: 26857816) Ivonnet P … Conner GE (Respiratory research 2016) 3 60
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60
  5. Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PMID: 18318008) Han G … Gu J (Proteomics 2008) 4 60

Products for MAGEC3 Gene

Sources for MAGEC3 Gene

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