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MAGEC3 Gene

protein-coding GIFtS: 40

GC0XP140753

melanoma antigen family C, 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CT7.2 ^¹, ², ³
HCA2 ^¹, ², ³
MAGE-C3 ^¹, ²
MAGEC4 ^²
MGC119270 ^²
MGC119271 ^²
OTTHUMP00000024185 ^²

Descriptions
Cancer/testis antigen 7.2 ^³
Hepatocellular carcinoma-associated antigen 2 ^³
MAGE family testis and tumor-specific protein ^²
MAGE-C3 antigen ^³
cancer/testis antigen family 7, member 2 ^²
hepatocellular carcinoma-associated protein HCA2 ^²
melanoma antigen family C, 3 ^²
melanoma antigen, family C, 3 protein ^²

External Ids
HGNC: 23798¹
Entrez Gene: 139081²
UniProtKB: Q8TD91³
Ensembl: ENSG00000165509⁷

Search outside databases for aliases for MAGEC3 gene

Previous GC identifers: GC0XP137783 GC0XP138859 GC0XP139619 GC0XP140651

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for MAGEC3:

This gene is a member of the MAGEC gene family. The members of this family are not expressed in

normal tissues, except for testis, and are expressed in tumors of various histological types. The

MAGEC genes are clustered on chromosome Xq26-q27. Two transcript variants encoding distinct

isoforms have been found for this gene. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAGEC3 gene

Entrez Gene cytogenetic band: Xq27.2 Ensembl cytogenetic band: Xq27.2 HGNC cytogenetic band: Xq27.2

MAGEC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP140753: (about GC identifiers)

Start:	140,753,768 bp from pter
End:	140,813,284 bp from pter
Size:	59,517 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011786.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MAGC3_HUMAN, Q8TD91 (See protein sequence)

Recommended Name: Melanoma-associated antigen C3

Size: 643 amino acids; 71909 Da

Secondary accessions: Q5JZ43 Q9BZ80

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_619647.1 NP_803251.1

ENSEMBL proteins:

ENSP00000298296 ENSP00000329145 ENSP00000386566

Human Recombinant Proteins

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	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for MAGEC3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for MAGEC3

Assays for MAGEC3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8TD91

ProtoNet protein and cluster: Q8TD91

UniProtKB/Swiss-Prot: MAGC3_HUMAN, Q8TD91

Similarity: Contains 2 MAGE domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGEC3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_177456

Applied Biosystems Silencer® siRNAs for MAGEC3

Sigma-Aldrich siRNA for MAGEC3

Sigma-Aldrich shRNA for MAGEC3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_138702
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_138702
untagged cDNA clones in CMV expression vector (see all 2): NM_138702

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_138702

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGEC3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGEC3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_177456

Sigma-Aldrich siRNA for MAGEC3

Sigma-Aldrich shRNA for MAGEC3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_138702 NM_177456

REFSEQ mRNAs for MAGEC3 gene (2 alternative transcripts):

NM_138702.1 NM_177456.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_138702 NM_177456

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_138702
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_138702
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_138702

Additional cDNA sequence:

AF490508.1 AK297650.1 BC103893.1 BC103894.1

2 DOTS entries:

DT.97819014 DT.100738207

4 AceView cDNA sequences:

NM_177456 AF490508 NM_138702 BM547686

highest scoring ESTs for MAGEC3:

AF490508 NM_138702 NM_177456 BC103893 BC103894 BM547686 DB309880 XM_066469

Unigene Cluster for MAGEC3:

Melanoma antigen family C, 3

Hs.356870 [show with all ESTs]

Unigene Representative Sequence: AF490508

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEC3

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11
SP1:													-		-		-
SP2:																	-
SP3:															-

About this scheme

ECgene alternative splicing isoforms for MAGEC3

3 Ensembl transcripts including schematic representations:

ENST00000298296 ENST00000329936 ENST00000409007

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAGEC3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAGEC3

¹ / ²

2 probe-sets matching MAGEC3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
216592_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
216592_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCCACCAACT

SOURCE GeneReport for Unigene cluster: Hs.356870
UniProtKB/Swiss-Prot: MAGC3_HUMAN, Q8TD91
Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in
tumors of different histological origins

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

ENSEMBL Gene Tree for MAGEC3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAGEC3 gene

MAGEC1² MAGEC2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/207 NCBI SNPs in MAGEC3 are shown (see all 207 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 87)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2205912^1,2	A,C,F,H	140811916(+)	`ACAGGC/TGACCT`	2	--	ut5¹ int¹ ese³		4		EU EA WA	418
	rs5954446^1,2	A,C,F,H	140753185(+)	`CTTACG/ATTGTT`	1	--	ng5¹		8		EU EA WA	622
	rs176026^1,2	A,C,F,H	140810793(+)	`CTGAAA/GCATTT`	2	A/T	mis¹ ut5¹		4		EU EA WA	410
	rs11095910^1,2	A,C,F,H	140794861(+)	`AAAGGT/ATGTGG`	1	M/L	mis¹		8		EU EA WA	721
	rs176024^1,2	C,F,H	140810730(+)	`GGTCAG/ACCTTG`	2	T/A	mis¹ ut5¹ ese³		8		EU EA WA	733
	rs7889660^1,2	C,F,H	140751819(+)	`gcaaaA/Gtgtct`	1	--	ng5¹		8		EU EA WA	608
	rs12852593^1,2	C,H	140794787(+)	`GAAGGT/ACAGTG`	1	V/D	mis¹ ese³		8		EU EA WA	628
	rs11095909^1,2	A,C	140794831(+)	`CCCTTC/TCCCTT`	1	S/P	mis¹ trp³		0	--	--	--	--
	rs6636497^1,2	H	140753507(+)	`ttggtC/Aacttt`	1	--	ng5¹		4		EU EA WA	408
	rs5908057^1,2	A,C,F,H	140760647(+)	`ATAATT/GTCATT`	1	--	int¹		4		EU EA WA	360

About this table

HapMap Linkage Disequilibrium images for MAGEC3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300469

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for MAGEC3 gene:

MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PubMed id 10861452)^{2, 3, 4} Lucas S.... Boon T. (2000)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008)⁴ Han G.... Gu J. (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 139081	HGNC: 23798	AceView: MAGEC3	Ensembl:ENSG00000165509	euGenes: HUgn139081
ECgene: MAGEC3	H-InvDB: MAGEC3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MAGEC3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MAGEC3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MAGEC3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAGEC3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAGEC3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MAGEC3		Browse small molecules at Sigma-Aldrich
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	Recombinant & Natural Proteins

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Search Novus for antibodies for MAGEC3

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MAGEC3 Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for MAGEC3

Summaries
for MAGEC3

Genomic Location
for MAGEC3

Proteins
for MAGEC3

Protein Domains/
Families
for MAGEC3

Gene Function
for MAGEC3

Pathways & Interactions
for MAGEC3

Drugs & Compounds
for MAGEC3

Transcripts
for MAGEC3

Expression
for MAGEC3

Orthologs
for MAGEC3

Paralogs
for MAGEC3

SNPs/Variants
for MAGEC3

Disorders & Mutations
for MAGEC3

Medical News
for MAGEC3

Publications
for MAGEC3

Search for MAGEC3

Genome Databases showing MAGEC3

Other Databases showing MAGEC3

Specialized Databases showing MAGEC3

Licensable Technologies
for MAGEC3

Services
for MAGEC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAGEC3 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor MAGEC3

Summariesfor MAGEC3

Genomic Locationfor MAGEC3

Proteinsfor MAGEC3

Protein Domains/Familiesfor MAGEC3

Gene Functionfor MAGEC3

Pathways & Interactionsfor MAGEC3

Drugs & Compoundsfor MAGEC3

Transcriptsfor MAGEC3

Expression for MAGEC3

Orthologsfor MAGEC3

Paralogsfor MAGEC3

SNPs/Variantsfor MAGEC3

Disorders & Mutationsfor MAGEC3

Medical Newsfor MAGEC3

Publicationsfor MAGEC3

Search for MAGEC3

Genome Databases showing MAGEC3

Other Databases showing MAGEC3

Specialized Databases showing MAGEC3

Licensable Technologiesfor MAGEC3

Servicesfor MAGEC3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAGEC3

Summaries
for MAGEC3

Genomic Location
for MAGEC3

Proteins
for MAGEC3

Protein Domains/
Families
for MAGEC3

Gene Function
for MAGEC3

Pathways & Interactions
for MAGEC3

Drugs & Compounds
for MAGEC3

Transcripts
for MAGEC3

Expression
for MAGEC3

Orthologs
for MAGEC3

Paralogs
for MAGEC3

SNPs/Variants
for MAGEC3

Disorders & Mutations
for MAGEC3

Medical News
for MAGEC3

Publications
for MAGEC3

Licensable Technologies
for MAGEC3

Services
for MAGEC3