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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGEC3 Gene

protein-coding   GIFtS: 44
GCID: GC0XP140926

Melanoma Antigen Family C, 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Melanoma Antigen Family C, 31 2     Member 21
Cancer/Testis Antigen 7.22 3     MAGE-C32
Hepatocellular Carcinoma-Associated Antigen 22 3     MAGEC42
CT7.22 3     Cancer/Testis Antigen Family 7, Member 22
HCA22 3     Hepatocellular Carcinoma-Associated Protein HCA22
MAGE-C3 Antigen2 3     MAGE Family Testis And Tumor-Specific Protein2
Cancer/Testis Antigen Family 71     Melanoma-Associated Antigen C32

External Ids:    HGNC: 237981   Entrez Gene: 1390812   Ensembl: ENSG000001655097   OMIM: 3004695   UniProtKB: Q8TD913   

Export aliases for MAGEC3 gene to outside databases

Previous GC identifers: GC0XP137783 GC0XP138859 GC0XP139619 GC0XP140651 GC0XP140753 GC0XP130029


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAGEC3 Gene:
This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues,
except for testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on
chromosome Xq26-q27. Two transcript variants encoding distinct isoforms have been found for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for MAGEC3 Gene: 
MAGEC3 (melanoma antigen family C, 3) is a protein-coding gene. Diseases associated with MAGEC3 include hepatocellular carcinoma, and melanoma. An important paralog of this gene is MAGEH1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGEC3 gene promoter:
         p53   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   CUTL1   POU3F2   LCR-F1   IRF-7A   NF-kappaB1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGEC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAGEC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq27.2   Ensembl cytogenetic band:  Xq27.2   HGNC cytogenetic band: Xq27.2

MAGEC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEC3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP140926:  view genomic region     (about GC identifiers)

Start:
140,926,102 bp from pter      End:
140,985,618 bp from pter
Size:
59,517 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAGC3_HUMAN, Q8TD91 (See protein sequence)
Recommended Name: Melanoma-associated antigen C3  
Size: 643 amino acids; 71909 Da
Secondary accessions: Q3SYA7 Q5JZ43 Q9BZ80
Alternative splicing: 2 isoforms:  Q8TD91-1   Q8TD91-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAGEC3: NX_Q8TD91

Explore proteomics data for MAGEC3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TD91

  • MAGEC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAGEC3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_619647.1  NP_803251.1  

    ENSEMBL proteins: 
     ENSP00000298296   ENSP00000386566   ENSP00000395092   ENSP00000441107   ENSP00000440444  
     ENSP00000438254  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry Q8TD91

    ProtoNet protein and cluster: Q8TD91

    UniProtKB/Swiss-Prot: MAGC3_HUMAN, Q8TD91
    Similarity: Contains 2 MAGE domains


    MAGEC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for MAGEC3:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAGEC3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEC3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAGEC3 (MAGC3)

    Search CenterWatch for drugs/clinical trials and news about MAGEC3 / MAGC3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for MAGEC3 gene (2 alternative transcripts): 
    NM_138702.1  NM_177456.2  

    Unigene Cluster for MAGEC3:

    Melanoma antigen family C, 3
    Hs.356870  [show with all ESTs]
    Unigene Representative Sequence: AF490508
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298296(uc011mwp.2) ENST00000483584 ENST00000409007 ENST00000448920
    ENST00000536088 ENST00000544766(uc004fbs.3 uc010nsj.3) ENST00000443323

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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEC3

    Additional mRNA sequence: 

    AF490508.1 AK297650.1 BC103893.1 BC103894.1 

    2 DOTS entries:

    DT.97819014  DT.100738207 

    4 AceView cDNA sequences:

    NM_177456 NM_138702 AF490508 BM547686 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEC3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                      -     -     -               
    SP2:                                                  -               
    SP3:                                            -                     


    ECgene alternative splicing isoforms for MAGEC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGEC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCACCAACT
    MAGEC3 Expression
    About this image


    See MAGEC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAGEC3

    SOURCE GeneReport for Unigene cluster: Hs.356870

    UniProtKB/Swiss-Prot: MAGC3_HUMAN, Q8TD91
    Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of
    different histological origins

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for MAGEC3 gene from 1/2 species (see all 2)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    28(a)
    possible ortholog
    X(119870193-119874265)


    ENSEMBL Gene Tree for MAGEC3 (if available)
    TreeFam Gene Tree for MAGEC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGEC3 gene
    MAGEH12  MAGEE22  MAGEE12  
    18/34 SIMAP similar genes for MAGEC3 using alignment to 3 protein entries:     MAGC3_HUMAN (see all proteins) (see all similar genes):
    MAGEC4    MAGEC1    MAGEA10    MAGEA8    MAGEH1    MAGEA2
    MAGEA2B    MAGEC2    MAGEE1    MAGEA9    MAGEB3    MAGEA6
    MAGEA11    MAGEA9B    MAGEB10    MAGEA3    MAGE-B1    MAGEA1

    MAGEC3 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for MAGEC3 (see all 6)
    PGOHUM00000241580 PGOHUM00000241581 PGOHUM00000250061 PGOHUM00000241583 PGOHUM00000242052


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1063 SNPs in MAGEC3 are shown (see all 1063)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512950161,2
    --140878753(+) TGACAA/GCCAAA 1 -- us2k10--------
    rs78896601,2
    C,F,H--140878778(+) gcaaaA/Gtgtct 1 -- us2k118Minor allele frequency- G:0.15NS EA NA WA 2039
    rs1456508311,2
    --140879039(+) GATGCA/GGGGCA 1 -- us2k10--------
    rs1849986811,2
    --140879165(+) TTCTTC/TATTTT 1 -- us2k10--------
    rs1895150831,2
    --140879340(+) TGCAGG/TTGCAA 1 -- us2k10--------
    rs1818481931,2
    --140879619(+) AGAAAC/TCATAT 1 -- us2k10--------
    rs1477571841,2
    --140879742(+) GTCCTC/TACTAA 1 -- us2k10--------
    rs735779561,2
    C,F--140879819(+) TGCAAC/TGTCCC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1501954171,2
    --140879830(+) GTGAGA/GTGGGA 1 -- us2k10--------
    rs1135289851,2
    C,F--140879874(+) CTGGGA/TCTGCA 1 -- us2k11Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for MAGEC3 (140926102 - 140985618 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MAGEC3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv522089CNV Gain19592680
    nsv483159CNV Complex15286789


    Human Gene Mutation Database (HGMD): MAGEC3

    Locus Specific Mutation Databases (LSDB): MAGEC3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300469    OMIM disorders: --

    2 diseases for MAGEC3:    About MalaCards
    hepatocellular carcinoma    melanoma


    MAGEC3 for disorders           About GeneDecksing


    Export disorders for MAGEC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGEC3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MAGEC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PubMed id 10861452)1, 2, 3 Lucas S.... Boon T. (2000)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008)2 Han G.... Gu J. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 139081 HGNC: 23798 AceView: MAGEC3 Ensembl:ENSG00000165509 euGenes: HUgn139081
    ECgene: MAGEC3 H-InvDB: MAGEC3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAGEC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEC3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAGEC3 gene:
    Search GeneIP for patents involving MAGEC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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