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Aliases for MAGEC3 Gene

Aliases for MAGEC3 Gene

  • Melanoma Antigen Family C3 2 3
  • Hepatocellular Carcinoma-Associated Antigen 2 3 4
  • Cancer/Testis Antigen 7.2 3 4
  • MAGE-C3 Antigen 3 4
  • CT7.2 3 4
  • HCA2 3 4
  • Hepatocellular Carcinoma-Associated Protein HCA2 3
  • MAGE Family Testis And Tumor-Specific Protein 3
  • Cancer/Testis Antigen Family 7, Member 2 3
  • Cancer/Testis Antigen Family 7 2
  • Melanoma-Associated Antigen C3 3
  • Melanoma Antigen Family C, 3 3
  • Member 2 2
  • MAGE-C3 3
  • MAGEC4 3

External Ids for MAGEC3 Gene

Summaries for MAGEC3 Gene

Entrez Gene Summary for MAGEC3 Gene

  • This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues, except for testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on chromosome Xq26-q27. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEC3 Gene

MAGEC3 (Melanoma Antigen Family C3) is a Protein Coding gene. Diseases associated with MAGEC3 include hepatocellular carcinoma. An important paralog of this gene is MAGEE1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEC3 Gene

Genomics for MAGEC3 Gene

Genomic Location for MAGEC3 Gene

Start:
141,838,316 bp from pter
End:
141,897,832 bp from pter
Size:
59,517 bases
Orientation:
Plus strand

Genomic View for MAGEC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEC3 Gene

Regulatory Elements for MAGEC3 Gene

Proteins for MAGEC3 Gene

  • Protein details for MAGEC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD91-MAGC3_HUMAN
    Recommended name:
    Melanoma-associated antigen C3
    Protein Accession:
    Q8TD91
    Secondary Accessions:
    • Q3SYA7
    • Q5JZ43
    • Q9BZ80

    Protein attributes for MAGEC3 Gene

    Size:
    643 amino acids
    Molecular mass:
    71909 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAGEC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGEC3 Gene

Proteomics data for MAGEC3 Gene at MOPED

Post-translational modifications for MAGEC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEC3 Gene

No data available for DME Specific Peptides for MAGEC3 Gene

Domains for MAGEC3 Gene

Protein Domains for MAGEC3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MAGC3_HUMAN
Domain:
  • Contains 2 MAGE domains.:
    • Q8TD91
genes like me logo Genes that share domains with MAGEC3: view

No data available for Gene Families for MAGEC3 Gene

Function for MAGEC3 Gene

Phenotypes for MAGEC3 Gene

GenomeRNAi human phenotypes for MAGEC3:
genes like me logo Genes that share phenotypes with MAGEC3: view

miRNA for MAGEC3 Gene

miRTarBase miRNAs that target MAGEC3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAGEC3 Gene

Localization for MAGEC3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEC3 Gene COMPARTMENTS Subcellular localization image for MAGEC3 gene
Compartment Confidence
cytosol 3
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MAGEC3 Gene

Pathways for MAGEC3 Gene

SuperPathways for MAGEC3 Gene

No Data Available

Interacting Proteins for MAGEC3 Gene

Gene Ontology (GO) - Biological Process for MAGEC3 Gene

None

No data available for Pathways by source for MAGEC3 Gene

Transcripts for MAGEC3 Gene

mRNA/cDNA for MAGEC3 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEC3 Gene

Melanoma antigen family C, 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: -
SP3: -

Relevant External Links for MAGEC3 Gene

GeneLoc Exon Structure for
MAGEC3
ECgene alternative splicing isoforms for
MAGEC3

Expression for MAGEC3 Gene

mRNA expression in normal human tissues for MAGEC3 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEC3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAGEC3 Gene

SOURCE GeneReport for Unigene cluster for MAGEC3 Gene Hs.356870

mRNA Expression by UniProt/SwissProt for MAGEC3 Gene

Q8TD91-MAGC3_HUMAN
Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.
genes like me logo Genes that share expressions with MAGEC3: view

Orthologs for MAGEC3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC741769 36
  • 93.88 (n)
  • 88.58 (a)
cow
(Bos Taurus)
Mammalia MAGEC3 37
  • 26 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 26 (a)
OneToMany
-- 37
  • 30 (a)
OneToMany
Species with no ortholog for MAGEC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEC3 Gene

ENSEMBL:
Gene Tree for MAGEC3 (if available)
TreeFam:
Gene Tree for MAGEC3 (if available)

Paralogs for MAGEC3 Gene

Paralogs for MAGEC3 Gene

genes like me logo Genes that share paralogs with MAGEC3: view

Variants for MAGEC3 Gene

Sequence variations from dbSNP and Humsavar for MAGEC3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs176022 -- 141,894,971(+) gggaa(A/G)gtggg intron-variant, upstream-variant-2KB
rs176023 -- 141,895,245(+) GCCCC(A/G)CCCCA intron-variant, upstream-variant-2KB
rs176024 - 141,895,278(+) GGTCA(A/G)CCTTG missense, reference, utr-variant-5-prime, upstream-variant-2KB
rs176025 -- 141,895,317(+) TTGCA(C/T)TGTGG reference, synonymous-codon, utr-variant-5-prime, upstream-variant-2KB
rs176026 - 141,895,341(+) CTGAA(A/G)CATTT missense, reference, utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAGEC3 Gene

Variant ID Type Subtype PubMed ID
nsv522089 CNV Gain 19592680
nsv483159 CNV Complex 15286789

Relevant External Links for MAGEC3 Gene

HapMap Linkage Disequilibrium report
MAGEC3
Human Gene Mutation Database (HGMD)
MAGEC3
Locus Specific Mutation Databases (LSDB)
MAGEC3

Disorders for MAGEC3 Gene

(1) MalaCards Diseases for MAGEC3 Gene

Search for MAGEC3 Gene in MalaCards »
genes like me logo Genes that share disorders with MAGEC3: view

No data available for UniProtKB/Swiss-Prot for MAGEC3 Gene

Publications for MAGEC3 Gene

  1. MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PMID: 10861452) Lucas S. … Boon T. (Int. J. Cancer 2000) 2 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PMID: 18318008) Han G. … Gu J. (Proteomics 2008) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MAGEC3 Gene

Sources for MAGEC3 Gene

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