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Aliases for MAGEC3 Gene

Aliases for MAGEC3 Gene

  • Melanoma Antigen Family C3 2 3
  • Hepatocellular Carcinoma-Associated Antigen 2 3 4
  • Cancer/Testis Antigen 7.2 3 4
  • MAGE-C3 Antigen 3 4
  • CT7.2 3 4
  • HCA2 3 4
  • Hepatocellular Carcinoma-Associated Protein HCA2 3
  • MAGE Family Testis And Tumor-Specific Protein 3
  • Cancer/Testis Antigen Family 7, Member 2 3
  • Cancer/Testis Antigen Family 7 2
  • Melanoma Antigen Family C, 3 3
  • Member 2 2
  • MAGE-C3 3
  • MAGEC4 3

External Ids for MAGEC3 Gene

Previous GeneCards Identifiers for MAGEC3 Gene

  • GC0XP137783
  • GC0XP138859
  • GC0XP139619
  • GC0XP140651
  • GC0XP140753
  • GC0XP140926
  • GC0XP130029

Summaries for MAGEC3 Gene

Entrez Gene Summary for MAGEC3 Gene

  • This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues, except for testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on chromosome Xq26-q27. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEC3 Gene

MAGEC3 (Melanoma Antigen Family C3) is a Protein Coding gene. An important paralog of this gene is MAGEE1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEC3 Gene

Genomics for MAGEC3 Gene

Regulatory Elements for MAGEC3 Gene

Genomic Location for MAGEC3 Gene

141,838,316 bp from pter
141,897,832 bp from pter
59,517 bases
Plus strand

Genomic View for MAGEC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEC3 Gene

Proteins for MAGEC3 Gene

  • Protein details for MAGEC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen C3
    Protein Accession:
    Secondary Accessions:
    • Q3SYA7
    • Q5JZ43
    • Q9BZ80

    Protein attributes for MAGEC3 Gene

    643 amino acids
    Molecular mass:
    71909 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAGEC3 Gene


neXtProt entry for MAGEC3 Gene

Proteomics data for MAGEC3 Gene at MOPED

Post-translational modifications for MAGEC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEC3 Gene

No data available for DME Specific Peptides for MAGEC3 Gene

Domains & Families for MAGEC3 Gene

Gene Families for MAGEC3 Gene

Protein Domains for MAGEC3 Gene


Suggested Antigen Peptide Sequences for MAGEC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 MAGE domains.
  • Contains 2 MAGE domains.
genes like me logo Genes that share domains with MAGEC3: view

Function for MAGEC3 Gene

genes like me logo Genes that share phenotypes with MAGEC3: view

Animal Model Products

CRISPR Products

miRNA for MAGEC3 Gene

miRTarBase miRNAs that target MAGEC3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEC3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEC3 Gene

Localization for MAGEC3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MAGEC3 Gene

Pathways & Interactions for MAGEC3 Gene

SuperPathways for MAGEC3 Gene

No Data Available

Interacting Proteins for MAGEC3 Gene

Gene Ontology (GO) - Biological Process for MAGEC3 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAGEC3 Gene

Drugs & Compounds for MAGEC3 Gene

No Compound Related Data Available

Transcripts for MAGEC3 Gene

mRNA/cDNA for MAGEC3 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEC3 Gene

Melanoma antigen family C, 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: -
SP3: -

Relevant External Links for MAGEC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEC3 Gene

mRNA expression in normal human tissues for MAGEC3 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEC3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.8).

Protein differential expression in normal tissues from HIPED for MAGEC3 Gene

This gene is overexpressed in Cervix (49.1) and Tlymphocyte (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEC3 Gene

SOURCE GeneReport for Unigene cluster for MAGEC3 Gene Hs.356870

mRNA Expression by UniProt/SwissProt for MAGEC3 Gene

Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.
genes like me logo Genes that share expression patterns with MAGEC3: view

Protein tissue co-expression partners for MAGEC3 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGEC3 Gene

Orthologs for MAGEC3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC741769 35
  • 93.88 (n)
  • 88.58 (a)
(Bos Taurus)
Mammalia MAGEC3 36
  • 26 (a)
(Canis familiaris)
Mammalia -- 36
  • 26 (a)
-- 36
  • 30 (a)
Species with no ortholog for MAGEC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEC3 Gene

Gene Tree for MAGEC3 (if available)
Gene Tree for MAGEC3 (if available)

Paralogs for MAGEC3 Gene

Paralogs for MAGEC3 Gene

genes like me logo Genes that share paralogs with MAGEC3: view

Variants for MAGEC3 Gene

Sequence variations from dbSNP and Humsavar for MAGEC3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs176022 -- 141,894,971(+) gggaa(A/G)gtggg intron-variant, upstream-variant-2KB
rs176023 -- 141,895,245(+) GCCCC(A/G)CCCCA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs176024 - 141,895,278(+) GGTCA(A/G)CCTTG missense, reference, utr-variant-5-prime, upstream-variant-2KB
rs176025 -- 141,895,317(+) TTGCA(C/T)TGTGG reference, synonymous-codon, utr-variant-5-prime, upstream-variant-2KB
rs176026 - 141,895,341(+) CTGAA(A/G)CATTT missense, reference, utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAGEC3 Gene

Variant ID Type Subtype PubMed ID
nsv522089 CNV Gain 19592680
nsv483159 CNV Complex 15286789

Variation tolerance for MAGEC3 Gene

Residual Variation Intolerance Score: 68.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.59; 72.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEC3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEC3 Gene

Disorders for MAGEC3 Gene

Relevant External Links for MAGEC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAGEC3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGEC3 Gene

Publications for MAGEC3 Gene

  1. MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PMID: 10861452) Lucas S. … Boon T. (Int. J. Cancer 2000) 2 67
  2. Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PMID: 18318008) Han G. … Gu J. (Proteomics 2008) 67
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for MAGEC3 Gene

Sources for MAGEC3 Gene

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