MAGEC3 Gene
protein-coding GIFtS: 44
GCID: GC0XP140926
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melanoma antigen family C, 3
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Aliases
for MAGEC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family C, 31 2 | | MAGE-C3 Antigen2 3 | | CT7.21 2 3 | | MAGEC42 | | HCA21 2 3 | | Cancer/Testis Antigen Family 7, Member 22 | | MAGE-C31 2 | | Hepatocellular Carcinoma-Associated Protein HCA22 | | Cancer/Testis Antigen 7.22 3 | | MAGE Family Testis And Tumor-Specific Protein2 | | Hepatocellular Carcinoma-Associated Antigen 22 3 | | Melanoma-Associated Antigen C32 |
Export aliases for MAGEC3 gene to outside databasesPrevious GC identifers: GC0XP137783 GC0XP138859 GC0XP139619 GC0XP140651 GC0XP140753 GC0XP130029 |
Summaries
for MAGEC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEC3:
This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues, exceptfor testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on chromosomeXq26-q27. Two transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jul2008)
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Genomic Views
for MAGEC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEC3 gene promoter:
p53 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) CUTL1 POU3F2 LCR-F1 IRF-7A NF-kappaB1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEC3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEC3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq27.2 Ensembl cytogenetic band: Xq27.2 HGNC cytogenetic band: Xq27.2MAGEC3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP140926: view genomic region
(about GC identifiers)
Start:
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140,926,102 bp from pter |
End:
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140,985,618 bp from pter |
Size:
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59,517 bases |
Orientation:
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plus strand |
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Proteins
for MAGEC3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGC3_HUMAN, Q8TD91 (See
protein sequence)Recommended Name: Melanoma-associated antigen C3 Size: 643 amino acids; 71909 Da
Secondary accessions: Q3SYA7 Q5JZ43 Q9BZ80Alternative splicing: 2 isoforms: Q8TD91-1 Q8TD91-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MAGEC3: NX_Q8TD91
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TD91
MAGEC3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_619647.1 NP_803251.1
ENSEMBL proteins: ENSP00000298296 ENSP00000386566 ENSP00000395092 ENSP00000441107 ENSP00000440444 ENSP00000438254
Human Recombinant Protein Products:
MAGEC3 Antibody Products:
Assay Products for MAGEC3: |
Protein
Domains /
Families
for MAGEC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEC3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TD91ProtoNet protein and cluster: Q8TD91 UniProtKB/Swiss-Prot: MAGC3_HUMAN, Q8TD91Similarity: Contains 2 MAGE domains |
Function
for MAGEC3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEC3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEC3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MAGEC3 (NM_138702) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEC3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEC3 |
2 GenomeRNAi human phenotypes for MAGEC3:
|
Pathways & Interactions
for MAGEC3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEC3
|
Drugs & Compounds
for MAGEC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEC3
Search CenterWatch for drugs/clinical trials and news about MAGEC3 / MAGC3
|
Transcripts
for MAGEC3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEC3 gene (2 alternative transcripts): NM_138702.1 NM_177456.2 Unigene Cluster for MAGEC3: Melanoma antigen family C, 3 Hs.356870 [show with all ESTs]Unigene Representative Sequence: AF4905087 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000298296(uc011mwp.2) ENST00000483584 ENST00000409007 ENST00000448920
ENST00000536088 ENST00000544766(uc004fbs.3 uc010nsj.3) ENST00000443323
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEC3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEC3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MAGEC3 (NM_138702) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEC3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEC3 |
Additional cDNA sequence: AF490508.1 AK297650.1 BC103893.1 BC103894.1 2 DOTS entries: DT.97819014 DT.100738207 4 AceView cDNA sequences: AF490508 NM_177456 NM_138702 BM547686
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEC3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
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| SP1: | | | | | | | | | | | | | - | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for MAGEC3
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Expression
for MAGEC3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCACCAACT
About this image
See MAGEC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEC3
SOURCE GeneReport for Unigene cluster: Hs.356870
UniProtKB/Swiss-Prot: MAGC3_HUMAN, Q8TD91Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of differenthistological origins
SABiosciences Custom PCR Arrays for MAGEC3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEC3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MAGEC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEC3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEC3 |
Orthologs
for MAGEC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for MAGEC3 gene from 3/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
27(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
20(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
15(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEC3 (if available)
TreeFam Gene Tree for MAGEC3 (if available) |
Paralogs
for MAGEC3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEC3 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGEA82 MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12
- MAGED12 MAGEA22 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2 MAGEE22
- MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/35 SIMAP similar genes for MAGEC3 using alignment to 3 protein entries: MAGC3_HUMAN (see all proteins)
(see all similar genes):MAGEC4 MAGEC1 MAGEA10 MAGEA8 MAGEH1 MAGEA2
MAGEA2B MAGEC2 MAGEE1 MAGEA9 MAGEB3 MAGEA6
MAGEA11 MAGEA9B MAGEB10 MAGEA3 MAGE-B1 MAGEA1
MAGEC3 for paralogs About GeneDecksing
5/6 Pseudogenes.org Pseudogenes for MAGEC3 (see all 6)
PGOHUM00000241580 PGOHUM00000241581 PGOHUM00000250061 PGOHUM00000241583 PGOHUM00000242052
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Genomic Variants
for MAGEC3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEC3 (140926102 - 140985618 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAGEC3
1 CNV: 0255
Locus Specific Mutation Databases (LSDB): MAGEC3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEC3 |
|
Disorders
/ Diseases
for MAGEC3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEC3 for disorders About GeneDecksing
OMIM gene information: 300469
OMIM disorders: --
3  diseases for MAGEC3: About MalaCardshepatocellular carcinoma melanoma carcinoma
Export disorders for MAGEC3 gene to outside databases
|
Publications
for MAGEC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEC3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAGEC3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PubMed id 10861452)1, 2, 3 Lucas S.... Boon T. (2000)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008)2 Han G.... Gu J. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for MAGEC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MAGEC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEC3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEC3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEC3 gene:
Search GeneIP for patents involving MAGEC3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEC3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | MAGEC3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEC3 |
|  |  |  | | | | Search ThermoFisher Antibodies for MAGEC3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEC3 |
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