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Aliases & Descriptions for MAGEC2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CT10 1 , 2 , 3 , 5 HCA587 2 , 3 , 5 MAGE-C2 1 MAGEE1 2 , 3 , 5 MGC13377 2 OTTHUMP00000024186 2
Descriptions Cancer/testis antigen 10 2 , 3 Hepatocellular carcinoma-associated antigen 587 3 MAGE-C2 antigen 2 , 3 MAGE-E1 antigen 3 cancer-testis antigen CT10 2 hepatocellular cancer antigen 587 2 melanoma antigen family C, 2 2 melanoma antigen, family E, 1 protein 2 melanoma antigen, family E, 1, cancer/testis specific 1 , 2 melanoma-associated antigen E1 2
Search outside databases for aliases for MAGEC2 genePrevious GC identifers: GC0XM139983 GC0XM141015
Summaries for MAGEC2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for MAGEC2 : This gene is related to members of the MAGEC gene family. It is not expressed in normal tissues,except for testis, and is expressed in tumors of various histological types. This gene and theMAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq] Gene Wiki entry for MAGEC2
Genomic Location for MAGEC2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MAGEC2 gene Entrez Gene cytogenetic band: Xq27 Ensembl cytogenetic band: Xq27.2 HGNC cytogenetic band: Xq27 MAGEC2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM141117:
(about GC identifiers )
Start:
141,117,796 bp from pter
End:
141,120,744 bp from pter
Size:
2,949 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000023.9 NT_011786.15 Proteins for MAGEC2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: MAGC2_HUMAN, Q9UBF1 (See
protein sequence )Recommended Name: Melanoma-associated antigen C2 Size : 373 amino acids; 41163 Da
Subcellular location : Cytoplasm. Nucleus. Note=Nuclear in germ cells. Cytoplasmic inwell-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiatedhepatocellular carcinoma
Developmental stage : Strongly expressed in spermatogonia and primary spermatocytes. At later stagesof maturation, expression gradually decreases and becomes undetectable in mature spermatids
Secondary accessions : Q5JZ00 Q96D45 Q9P1M6 Q9P1M7
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_057333.1 ENSEMBL proteins: ENSP00000354660 ENSP00000385500 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for MAGEC2: Assays for MAGEC2:
Protein
Domains/ Families for MAGEC2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UBF1 ProtoNet protein and cluster: Q9UBF1
1 Blocks protein family : IPB002190 MAGE protein UniProtKB/Swiss-Prot: MAGC2_HUMAN, Q9UBF1 Similarity : Contains 1 MAGE domain
Gene Function for MAGEC2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): BC005891 Applied Biosystems Silencer ® siRNAs for MAGEC2 Sigma-Aldrich siRNA for MAGEC2 Sigma-Aldrich shRNA for MAGEC2 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016249                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016249                                  untagged cDNA clone in CMV expression vector: NM_016249  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016249 Pathways & Interactions for MAGEC2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for MAGEC2 5 Interacting proteins for MAGEC2 (ENSP00000354660 3 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for MAGEC2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for MAGEC2
Transcripts for MAGEC2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): BC005891 Sigma-Aldrich siRNA for MAGEC2 Sigma-Aldrich shRNA for MAGEC2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_016249
REFSEQ mRNAs for MAGEC2 gene: NM_016249.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016249
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016249                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016249                                  untagged cDNA clone in CMV expression vector: NM_016249  
Additional cDNA sequence: AF116194.1 AF151378.1 AF196482.1 AK313591.1 BC005891.2 BC013318.1 CR457168.1
1 DOTS entry : DT.405691
24/77 AceView cDNA sequences (see all 77
):BE729944 BU188257 BC005891 BM548987 BE302201 AA813168 BE385327 BQ773540 BE384089 BQ772609 AF151378 BQ422712 BM550492 CA414295 BM473867 BE274181 BF025766 AF116194 AA581014 BE891830 BE385895 BE391951 BG282180 BU178455
highest scoring ESTs for MAGEC2 :AA581014 AA863371 AF116194 AF151378 AF196482 BC013318 BE274181 BE276085 BE303049 BE384089
Unigene Cluster for MAGEC2: Melanoma antigen family C, 2 Hs.123536 [show with all ESTs ] Unigene Representative Sequence: BC013318 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000247452
ENST00000406005
Expression for MAGEC2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MAGEC2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MAGEC2 1 / 2 / 3
3 probe-sets matching MAGEC2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TATTGCTCTTSOURCE GeneReport for Unigene cluster: Hs.123536 UniProtKB/Swiss-Prot: MAGC2_HUMAN, Q9UBF1 Tissue specificity : Not expressed in normal tissues, except in germ cells in the seminiferoustubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma,lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung cancer and livercancer. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiationand protein expression, i.e. the lower the differentiation, the higher percentage of expression
Orthologs for MAGEC2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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ENSEMBL Gene Tree for MAGEC2 Paralogs for MAGEC2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MAGEC2 gene MAGEC1 2 MAGEC3 2 Pseudogenes 3 related pseudogenes
SNPs/Variants for MAGEC2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MAGEC2 (up to first 250kb)
Disorders & Mutations for MAGEC2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 300468 5 Novoseek disease relationships for MAGEC2 gene
About this table
Medical News for MAGEC2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MAGEC2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/20 PubMed articles for MAGEC2 gene (see all 20
): CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational difference analysis. (PubMed id 10699956) 1, 2, 3, 4 Gure A.O.... Chen Y.-T. (2000) HCA587 antigen expression in normal tissues and cancers: correlation with tumor differentiation in hepatocellular carcinoma. (PubMed id 12920247) 1, 3, 4 Li B....Chen W.-F. (2003) The DNA sequence of the human X chromosome. (PubMed id 15772651) 3, 4 Ross M.T.... Bentley D.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. (PubMed id 12097419) 3, 4 Wang Y....Chen W.F. (2002) MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PubMed id 10861452) 3, 4 Lucas S.... Boon T. (2000) Two new tumor-specific antigenic peptides encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2. (PubMed id 14999777) 1, 3 Ma W....Van den Eynde B.J. (2004) [Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery] (PubMed id 15061963) 1, 3 Wang Y....Zhang L.J. (2004) Frequent expression of the novel cancer testis antigen MAGE-C2/CT-10 in hepatocellular carcinoma. (PubMed id 18942708) 3 Riener M.O....Jochum W. (2009) Epigenetic control of MAGE gene expression by the KIT tyrosine kinase. (PubMed id 17495964) 3 Yang B....Longley B.J. (2007)
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Genome Databases showing MAGEC2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing MAGEC2
(According to HUGE )
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Specialized Databases showing MAGEC2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for MAGEC2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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