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MAGEC2 Gene

protein-coding   GIFtS: 53

GC0XM141117
melanoma antigen family C, 2
(Previous names: melanoma antigen, family E, 1, cancer/testis specific )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MAGEE1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CT10 1, 2, 3, 5
HCA587 2, 3, 5
MAGE-C2 1
MAGEE1 2, 3, 5
MGC13377 2
OTTHUMP00000024186 2
Descriptions
Cancer/testis antigen 10 2, 3
Hepatocellular carcinoma-associated antigen 587 3
MAGE-C2 antigen 2, 3
MAGE-E1 antigen 3
cancer-testis antigen CT10 2
hepatocellular cancer antigen 587 2
melanoma antigen family C, 2 2
melanoma antigen, family E, 1 protein 2
melanoma antigen, family E, 1, cancer/testis specific 1, 2
melanoma-associated antigen E1 2
External Ids
HGNC: 135741
Entrez Gene: 514382
UniProtKB: Q9UBF13
Ensembl: ENSG000000467747
Search outside databases for aliases for MAGEC2 gene

Previous GC identifers: GC0XM139983 GC0XM141015

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for MAGEC2:
This gene is related to members of the MAGEC gene family. It is not expressed in normal tissues,
except for testis, and is expressed in tumors of various histological types. This gene and the
MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq]

Gene Wiki entry for MAGEC2
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MAGEC2 gene  

Entrez Gene cytogenetic band: Xq27   Ensembl cytogenetic band:  Xq27.2   HGNC cytogenetic band: Xq27

MAGEC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM141117:     (about GC identifiers)

Start:
141,117,796 bp from pter
End:
141,120,744 bp from pter
Size:
2,949 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011786.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MAGC2_HUMAN, Q9UBF1 (See protein sequence)
Recommended Name: Melanoma-associated antigen C2  
Size: 373 amino acids; 41163 Da
Subcellular location: Cytoplasm. Nucleus. Note=Nuclear in germ cells. Cytoplasmic in
well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated
hepatocellular carcinoma
Developmental stage: Strongly expressed in spermatogonia and primary spermatocytes. At later stages
of maturation, expression gradually decreases and becomes undetectable in mature spermatids
Secondary accessions: Q5JZ00 Q96D45 Q9P1M6 Q9P1M7

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_057333.1  

    ENSEMBL proteins: 
    ENSP00000354660 ENSP00000385500 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (MAGEE1)
    Human Recombinant Proteins from Abnova (MAGEC2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA12920247
    GO:0005737 cytoplasm IDA12920247
    About this table

    Antibodies for MAGEC2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (MAGEE1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (MAGEC2)
    Novus Biologicals Antibody for MAGEC2

    Assays for MAGEC2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR002190 MAGE


       GeneDecks  MAGEC2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UBF1

    ProtoNet protein and cluster: Q9UBF1

    1 Blocks protein family: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGC2_HUMAN, Q9UBF1
    Similarity: Contains 1 MAGE domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MAGEC2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC005891

                  Applied Biosystems Silencer® siRNAs for MAGEC2

                  Sigma-Aldrich siRNA for MAGEC2  
                         Sigma-Aldrich shRNA for MAGEC2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for MAGEC2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_016249
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_016249
                                     untagged cDNA clone in CMV expression vector: NM_016249 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_016249

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  MAGEC2 


    5 Interacting proteins for MAGEC2 (ENSP000003546603) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKENSP000003005743STRING (score=.891)
    CRKLENSP000003463003STRING (score=.839)
    SRCENSP000003626593STRING (score=.822)
    SSX1ENSP000003661183STRING (score=.74)
    CTAG2ENSP000002473063STRING (score=.714)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for MAGEC2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MAGEC2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC005891

                  Sigma-Aldrich siRNA for MAGEC2  
                         Sigma-Aldrich shRNA for MAGEC2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_016249  

    REFSEQ mRNAs for MAGEC2 gene: 

    NM_016249.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_016249  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_016249
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_016249
                                     untagged cDNA clone in CMV expression vector: NM_016249 

    Additional cDNA sequence: 

    AF116194.1 AF151378.1 AF196482.1 AK313591.1 BC005891.2 BC013318.1 CR457168.1 

    1 DOTS entry:

    DT.405691 

    24/77 AceView cDNA sequences (see all 77 ):

    BE729944 BU188257 BC005891 BM548987 BE302201 AA813168 BE385327 BQ773540 
    BE384089 BQ772609 AF151378 BQ422712 BM550492 CA414295 BM473867 BE274181 
    BF025766 AF116194 AA581014 BE891830 BE385895 BE391951 BG282180 BU178455 

    highest scoring ESTs for MAGEC2:

    AA581014 AA863371 AF116194 AF151378 AF196482 BC013318 BE274181 BE276085 BE303049 BE384089 

    Unigene Cluster for MAGEC2:

    Melanoma antigen family C, 2
    Hs.123536  [show with all ESTs]
    Unigene Representative Sequence: BC013318


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000247452  ENST00000406005  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    MAGEC2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for MAGEC2

    1 / 2 / 3

    3 probe-sets matching MAGEC2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    76601_at2, 3 U95-D 1 1.00 1.00 1.00 1.00 AA863371 0.80 1.00 0.91 1

    220062_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_016249 0.60 1.00 0.82 1

    220062_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TATTGCTCTT

    SOURCE GeneReport for Unigene cluster: Hs.123536

    UniProtKB/Swiss-Prot: MAGC2_HUMAN, Q9UBF1
    Tissue specificity: Not expressed in normal tissues, except in germ cells in the seminiferous
    tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma,
    lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung cancer and liver
    cancer. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation
    and protein expression, i.e. the lower the differentiation, the higher percentage of expression

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    ENSEMBL Gene Tree for MAGEC2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for MAGEC2 gene
    MAGEC12  MAGEC32  

    Pseudogenes
    3 related pseudogenes


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/22 NCBI SNPs in MAGEC2 are shown (see all 22 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 25)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs22811501,2
    A,C,F,H141117528(+) AGAGAA/GGCAAC 1 -- ng514Minor allele frequency- G:0.42EU EA WA 416
    rs22330581,2
    A,C,F,H141121027(-) AAGGAC/TGGTGA 1 -- ng3111Minor allele frequency- T:0.44EU EA WA NA 750
    --
    rs15695641,2
    C,F,H141121865(+) CCGCAC/GTTCTA 1 -- ng317Minor allele frequency- G:0.15EU EA WA NA 560
    rs70625301,2
    F,H141122462(+) cgatgG/Tggata 1 -- ng314Minor allele frequency- T:0.02EU EA WA 396
    rs22330571,2
    F,H141121472(-) TTTAGG/AAGTCA 1 -- ng314Minor allele frequency- A:0.01EU EA WA 418
    rs22330601,2
    C,H141118944(-) AGGCAG/CAGATG 1 Q/E mis1 ese34Minor allele frequency- C:0.00EU EA WA 418
    rs120092271,2
    C141120570(+) GCAGCA/GCAGTA 1 -- ut51 ese30--------
    --
    rs178554381,2
    H141119405(+) TGTCAA/GCGTTG 1 V/A mis14Minor allele frequency- G:0.00EU EA WA 418
    --
    rs110959511,2
    C141120705(+) TGCCTC/TCGATC 1 -- ut51 ese30--------
    rs37652721,2
    A,C,F,H141118531(+) GCTCTT/CGGACC 1 P/P syn15Minor allele frequency- C:0.27EU EA WA NA 494
    About this table

    HapMap Linkage Disequilibrium images for MAGEC2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 300468

    5 Novoseek disease relationships for MAGEC2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 51.19 2 14999777 (1), 10699956 (1)
    hepatocellular carcinoma 48.72 2 12920247 (1), 15237429 (1)
    cirrhosis 35.04 2 12921655 (1), 15237429 (1)
    tumors 33.06 6 12920247 (2), 14999777 (2), 15061963 (1)
    cancer 27.03 2 12920247 (1), 10699956 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/20 PubMed articles for MAGEC2 gene (see all 20 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 51438 HGNC: 13574 AceView: MAGEC2 Ensembl:ENSG00000046774 euGenes: HUgn51438
    ECgene: MAGEC2 H-InvDB: MAGEC2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for MAGEC2 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for MAGEC2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for MAGEC2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for MAGEC2 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for MAGEC2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

     Recombinant Proteins (MAGEC2)
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     Search for Chimera RNAi
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     Custom Service for Rabbit Pab from Full-length Protein
      
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     Recombinant Proteins
    (MAGEE1)
     Antibodies (MAGEE1)
     Search OriGene for MAGEC2
     Search Tocris compounds for MAGEC2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for MAGEC2

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