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Aliases for MAGEC2 Gene

Aliases for MAGEC2 Gene

  • Melanoma Antigen Family C2 2 3
  • Cancer/Testis Antigen 10 2 3 4
  • MAGEE1 3 4 6
  • HCA587 3 4 6
  • CT10 3 4 6
  • Melanoma Antigen, Family E, 1, Cancer/Testis Specific 2 3
  • Hepatocellular Carcinoma-Associated Antigen 587 3 4
  • MAGE-E1 Antigen 3 4
  • MAGE-C2 Antigen 3 4
  • Hepatocellular Cancer Antigen 587 3
  • Melanoma-Associated Antigen C2 3
  • Melanoma Antigen Family C, 2 3
  • MAGEC2 6

External Ids for MAGEC2 Gene

Previous Symbols for MAGEC2 Gene

  • MAGEE1

Summaries for MAGEC2 Gene

Entrez Gene Summary for MAGEC2 Gene

  • This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]

GeneCards Summary for MAGEC2 Gene

MAGEC2 (Melanoma Antigen Family C2) is a Protein Coding gene. Diseases associated with MAGEC2 include brain cancer and testicular germ cell tumor. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is MAGED1.

UniProtKB/Swiss-Prot for MAGEC2 Gene

  • Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.

Gene Wiki entry for MAGEC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEC2 Gene

Genomics for MAGEC2 Gene

Genomic Location for MAGEC2 Gene

Start:
142,202,342 bp from pter
End:
142,205,290 bp from pter
Size:
2,949 bases
Orientation:
Minus strand

Genomic View for MAGEC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEC2 Gene

Regulatory Elements for MAGEC2 Gene

Transcription factor binding sites by QIAGEN in the MAGEC2 gene promoter:

Proteins for MAGEC2 Gene

  • Protein details for MAGEC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBF1-MAGC2_HUMAN
    Recommended name:
    Melanoma-associated antigen C2
    Protein Accession:
    Q9UBF1
    Secondary Accessions:
    • Q5JZ00
    • Q96D45
    • Q9P1M6
    • Q9P1M7

    Protein attributes for MAGEC2 Gene

    Size:
    373 amino acids
    Molecular mass:
    41163 Da
    Quaternary structure:
    • Interacts with TRIM28 and UBE2H.

neXtProt entry for MAGEC2 Gene

Proteomics data for MAGEC2 Gene at MOPED

Post-translational modifications for MAGEC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEC2 Gene

Domains for MAGEC2 Gene

Protein Domains for MAGEC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBF1

UniProtKB/Swiss-Prot:

MAGC2_HUMAN
Domain:
  • Contains 1 MAGE domain.:
    • Q9UBF1
genes like me logo Genes that share domains with MAGEC2: view

No data available for Gene Families for MAGEC2 Gene

Function for MAGEC2 Gene

Molecular function for MAGEC2 Gene

UniProtKB/Swiss-Prot Function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.

Gene Ontology (GO) - Molecular Function for MAGEC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20864041
GO:0031625 ubiquitin protein ligase binding IDA 20864041
genes like me logo Genes that share ontologies with MAGEC2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MAGEC2 Gene

Localization for MAGEC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEC2 Gene

Cytoplasm. Nucleus. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEC2 Gene COMPARTMENTS Subcellular localization image for MAGEC2 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAGEC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12920247
GO:0005737 cytoplasm IDA 12920247
genes like me logo Genes that share ontologies with MAGEC2: view

Pathways for MAGEC2 Gene

SuperPathways for MAGEC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044257 cellular protein catabolic process IMP 20864041
GO:0051443 positive regulation of ubiquitin-protein transferase activity IMP 20864041
genes like me logo Genes that share ontologies with MAGEC2: view

No data available for Pathways by source for MAGEC2 Gene

Transcripts for MAGEC2 Gene

mRNA/cDNA for MAGEC2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(77) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEC2 Gene

Melanoma antigen family C, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEC2 Gene

No ASD Table

Relevant External Links for MAGEC2 Gene

GeneLoc Exon Structure for
MAGEC2
ECgene alternative splicing isoforms for
MAGEC2

Expression for MAGEC2 Gene

mRNA expression in normal human tissues for MAGEC2 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEC2 Gene

This gene is overexpressed in Testis (51.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAGEC2 Gene

SOURCE GeneReport for Unigene cluster for MAGEC2 Gene Hs.123536

mRNA Expression by UniProt/SwissProt for MAGEC2 Gene

Q9UBF1-MAGC2_HUMAN
Tissue specificity: Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression.
genes like me logo Genes that share expressions with MAGEC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGEC2 Gene

Orthologs for MAGEC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEC2 35
  • 98.02 (n)
  • 95.93 (a)
MAGEC2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 42 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 41 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 4930550L24Rik 36
  • 36 (a)
ManyToMany
Species with no ortholog for MAGEC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEC2 Gene

ENSEMBL:
Gene Tree for MAGEC2 (if available)
TreeFam:
Gene Tree for MAGEC2 (if available)

Paralogs for MAGEC2 Gene

Pseudogenes.org Pseudogenes for MAGEC2 Gene

genes like me logo Genes that share paralogs with MAGEC2: view

Variants for MAGEC2 Gene

Sequence variations from dbSNP and Humsavar for MAGEC2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1569564 -- 142,206,413(+) CCGCA(C/G)TTCTA upstream-variant-2KB
rs2233057 -- 142,206,020(-) TTTAG(A/G)AGTCA upstream-variant-2KB
rs2233058 -- 142,205,575(-) AAGGA(C/T)GGTGA upstream-variant-2KB
rs2233059 -- 142,205,414(-) CTGGG(A/T)GGTGG upstream-variant-2KB
rs2233060 -- 142,203,492(-) AGGCA(C/G)AGATG missense, reference

Relevant External Links for MAGEC2 Gene

HapMap Linkage Disequilibrium report
MAGEC2
Locus Specific Mutation Databases (LSDB)
MAGEC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEC2 Gene

Disorders for MAGEC2 Gene

(5) Novoseek inferred disease relationships for MAGEC2 Gene

Disease -log(P) Hits PubMed IDs
melanoma 50.3 2
hepatocellular carcinoma 47.6 2
cirrhosis 34 2
tumors 32 5
cancer 25.6 2

Relevant External Links for MAGEC2

Genetic Association Database (GAD)
MAGEC2
Human Genome Epidemiology (HuGE) Navigator
MAGEC2
genes like me logo Genes that share disorders with MAGEC2: view

No data available for UniProtKB/Swiss-Prot for MAGEC2 Gene

Publications for MAGEC2 Gene

  1. CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational difference analysis. (PMID: 10699956) Gure A.O. … Chen Y.-T. (Int. J. Cancer 2000) 2 3 4 23
  2. HCA587 antigen expression in normal tissues and cancers: correlation with tumor differentiation in hepatocellular carcinoma. (PMID: 12920247) Li B. … Chen W.-F. (Lab. Invest. 2003) 3 4 23
  3. Two new tumor-specific antigenic peptides encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2. (PMID: 14999777) Ma W. … Van den Eynde B.J. (Int. J. Cancer 2004) 3 23
  4. [Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery]. (PMID: 15061963) Wang Y. … Zhang L.J. (Zhonghua Yi Xue Za Zhi 2004) 3 23
  5. MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PMID: 10861452) Lucas S. … Boon T. (Int. J. Cancer 2000) 3 4

Products for MAGEC2 Gene

Sources for MAGEC2 Gene

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