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Aliases for MAGEC1 Gene

Aliases for MAGEC1 Gene

  • MAGE Family Member C1 2 3 5
  • Cancer/Testis Antigen Family 7, Member 1 2 3
  • Melanoma Antigen Family C1 2 3
  • Cancer/Testis Antigen 7.1 3 4
  • MAGE-C1 Antigen 3 4
  • CT7.1 3 4
  • Melanoma-Associated Antigen C1 3
  • Melanoma Antigen Family C, 1 3
  • CT7 3

External Ids for MAGEC1 Gene

Previous GeneCards Identifiers for MAGEC1 Gene

  • GC0XP135521
  • GC0XP137849
  • GC0XP138924
  • GC0XP139685
  • GC0XP140717
  • GC0XP140819
  • GC0XP140991
  • GC0XP130087

Summaries for MAGEC1 Gene

Entrez Gene Summary for MAGEC1 Gene

  • This gene is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, and therefore is about 800 aa longer than the other MAGE proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEC1 Gene

MAGEC1 (MAGE Family Member C1) is a Protein Coding gene. Diseases associated with MAGEC1 include Mucosal Melanoma and Spermatocytoma. An important paralog of this gene is MAGEC3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEC1 Gene

Genomics for MAGEC1 Gene

Regulatory Elements for MAGEC1 Gene

Genomic Location for MAGEC1 Gene

141,903,856 bp from pter
141,909,401 bp from pter
5,546 bases
Plus strand

Genomic View for MAGEC1 Gene

Genes around MAGEC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEC1 Gene

Proteins for MAGEC1 Gene

  • Protein details for MAGEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen C1
    Protein Accession:
    Secondary Accessions:
    • A0PK03
    • O75451
    • Q8TCV4

    Protein attributes for MAGEC1 Gene

    1142 amino acids
    Molecular mass:
    123643 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAGEC1 Gene


neXtProt entry for MAGEC1 Gene

Post-translational modifications for MAGEC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEC1 Gene

Domains & Families for MAGEC1 Gene

Gene Families for MAGEC1 Gene

Protein Domains for MAGEC1 Gene


Suggested Antigen Peptide Sequences for MAGEC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MAGE domain.
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEC1: view

Function for MAGEC1 Gene

Molecular function for MAGEC1 Gene

GENATLAS Biochemistry:
melanoma antigen,family C,member 1,expressed in a significant proportion of tumors of various histological types and in normal testis

Gene Ontology (GO) - Molecular Function for MAGEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17137291
genes like me logo Genes that share ontologies with MAGEC1: view

Phenotypes for MAGEC1 Gene

genes like me logo Genes that share phenotypes with MAGEC1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEC1 Gene

Localization for MAGEC1 Gene

Subcellular locations from

Jensen Localization Image for MAGEC1 Gene COMPARTMENTS Subcellular localization image for MAGEC1 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEC1 Gene

Pathways & Interactions for MAGEC1 Gene

SuperPathways for MAGEC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAGEC1 Gene

Transcripts for MAGEC1 Gene

mRNA/cDNA for MAGEC1 Gene

Unigene Clusters for MAGEC1 Gene

Melanoma antigen family C, 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEC1 Gene

No ASD Table

Relevant External Links for MAGEC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAGEC1 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEC1 Gene

This gene is overexpressed in Testis (x48.9).

Protein differential expression in normal tissues from HIPED for MAGEC1 Gene

This gene is overexpressed in Bone (28.1), Testis (25.4), and Ovary (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAGEC1 Gene

Protein tissue co-expression partners for MAGEC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAGEC1 Gene:


SOURCE GeneReport for Unigene cluster for MAGEC1 Gene:


mRNA Expression by UniProt/SwissProt for MAGEC1 Gene:

Tissue specificity: Expressed in testis and in tumors of a wide variety of histologic types.
genes like me logo Genes that share expression patterns with MAGEC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGEC1 Gene

Orthologs for MAGEC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAGEC1 34
  • 88.76 (n)
(Canis familiaris)
Mammalia -- 35
  • 43 (a)
(Bos Taurus)
Mammalia MAGEA11 35
  • 42 (a)
(Mus musculus)
Mammalia 4933402E13Rik 35
  • 32 (a)
Species where no ortholog for MAGEC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEC1 Gene

Gene Tree for MAGEC1 (if available)
Gene Tree for MAGEC1 (if available)

Paralogs for MAGEC1 Gene

Variants for MAGEC1 Gene

Sequence variations from dbSNP and Humsavar for MAGEC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1003682 -- 141,903,065(+) GTCCC(C/T)GGAGA upstream-variant-2KB
rs1055491 -- 141,906,336(+) CTCCT(C/T)CTCCT reference, missense
rs109168 -- 141,904,305(+) GGTGT(A/G)GGGGA intron-variant
rs111335385 -- 141,907,149(+) TCCTC(A/G)GAGCC reference, missense
rs111723844 -- 141,907,209(+) TCAGG(A/G)GGAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAGEC1 Gene

Variant ID Type Subtype PubMed ID
esv1703664 CNV insertion 17803354
esv2740535 CNV deletion 23290073
esv2740536 CNV deletion 23290073
esv2740537 CNV deletion 23290073
esv2740538 CNV deletion 23290073
nsv9985 CNV gain 18304495

Variation tolerance for MAGEC1 Gene

Residual Variation Intolerance Score: 100% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.72; 94.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEC1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEC1 Gene

Disorders for MAGEC1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MAGEC1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mucosal melanoma
  • spermatocytic seminoma
  • parapsoriasis nos
multiple myeloma
  • myeloma, multiple amyloidosis, systemic, included
malignant melanoma, somatic
  • dysplastic nevus syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAGEC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEC1 Gene

Publications for MAGEC1 Gene

  1. Identification of a new MAGE gene with tumor-specific expression by representational difference analysis. (PMID: 9485030) Lucas S. … Boon T. (Cancer Res. 1998) 2 3 4 22 64
  2. Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. (PMID: 9618514) Chen Y.-T. … Old L.J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 64
  3. Cellular immune responses against CT7 (MAGE-C1) and humoral responses against other cancer-testis antigens in multiple myeloma patients. (PMID: 20108890) Lendvai N. … Cho H.J. (Cancer Immun. 2010) 3 22 64
  4. Frequent MAGE mutations in human melanoma. (PMID: 20862285) Caballero O.L. … Simpson A.J. (PLoS ONE 2010) 3 46 64
  5. Expression of cancer-testis antigen CT7 (MAGE-C1) in breast cancer: an immunohistochemical study with emphasis on prognostic utility. (PMID: 17607369) KrA1ger S. … Friedrich M. (Pathol. Oncol. Res. 2007) 3 22 64

Products for MAGEC1 Gene

Sources for MAGEC1 Gene

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