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Aliases for MAGEC1 Gene

Aliases for MAGEC1 Gene

  • Melanoma Antigen Family C1 2 3
  • Cancer/Testis Antigen 7.1 3 4
  • MAGE-C1 Antigen 3 4
  • CT7.1 3 4
  • Cancer/Testis Antigen Family 7, Member 1 3
  • Cancer/Testis Antigen Family 7 2
  • Melanoma-Associated Antigen C1 3
  • Melanoma Antigen Family C, 1 3
  • Member 1 2
  • CT7 3

External Ids for MAGEC1 Gene

Previous GeneCards Identifiers for MAGEC1 Gene

  • GC0XP135521
  • GC0XP137849
  • GC0XP138924
  • GC0XP139685
  • GC0XP140717
  • GC0XP140819
  • GC0XP140991
  • GC0XP130087

Summaries for MAGEC1 Gene

Entrez Gene Summary for MAGEC1 Gene

  • This gene is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, and therefore is about 800 aa longer than the other MAGE proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEC1 Gene

MAGEC1 (Melanoma Antigen Family C1) is a Protein Coding gene. Diseases associated with MAGEC1 include mucosal melanoma and melanoma. An important paralog of this gene is MAGED1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEC1 Gene

Genomics for MAGEC1 Gene

Regulatory Elements for MAGEC1 Gene

Genomic Location for MAGEC1 Gene

141,903,856 bp from pter
141,909,401 bp from pter
5,546 bases
Plus strand

Genomic View for MAGEC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEC1 Gene

Proteins for MAGEC1 Gene

  • Protein details for MAGEC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen C1
    Protein Accession:
    Secondary Accessions:
    • A0PK03
    • O75451
    • Q8TCV4

    Protein attributes for MAGEC1 Gene

    1142 amino acids
    Molecular mass:
    123643 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAGEC1 Gene


neXtProt entry for MAGEC1 Gene

Proteomics data for MAGEC1 Gene at MOPED

Post-translational modifications for MAGEC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MAGEC1 Gene

Domains for MAGEC1 Gene

Protein Domains for MAGEC1 Gene


Suggested Antigen Peptide Sequences for MAGEC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MAGE domain.
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEC1: view

No data available for Gene Families for MAGEC1 Gene

Function for MAGEC1 Gene

Molecular function for MAGEC1 Gene

GENATLAS Biochemistry:
melanoma antigen,family C,member 1,expressed in a significant proportion of tumors of various histological types and in normal testis

Gene Ontology (GO) - Molecular Function for MAGEC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17137291
genes like me logo Genes that share ontologies with MAGEC1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEC1 Gene

Localization for MAGEC1 Gene

Subcellular locations from

Jensen Localization Image for MAGEC1 Gene COMPARTMENTS Subcellular localization image for MAGEC1 gene
Compartment Confidence
cytosol 2
golgi apparatus 1
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEC1 Gene

Pathways for MAGEC1 Gene

SuperPathways for MAGEC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEC1 Gene


No data available for Pathways by source for MAGEC1 Gene

Transcripts for MAGEC1 Gene

mRNA/cDNA for MAGEC1 Gene

Unigene Clusters for MAGEC1 Gene

Melanoma antigen family C, 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEC1 Gene

No ASD Table

Relevant External Links for MAGEC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEC1 Gene

mRNA expression in normal human tissues for MAGEC1 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEC1 Gene

This gene is overexpressed in Testis (48.9).

Protein differential expression in normal tissues for MAGEC1 Gene

This gene is overexpressed in Bone (28.1), Testis (25.4), and Ovary (14.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEC1 Gene

SOURCE GeneReport for Unigene cluster for MAGEC1 Gene Hs.132194

mRNA Expression by UniProt/SwissProt for MAGEC1 Gene

Tissue specificity: Expressed in testis and in tumors of a wide variety of histologic types
genes like me logo Genes that share expressions with MAGEC1: view

Expression partners for MAGEC1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGEC1 Gene

Orthologs for MAGEC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAGEC1 35
  • 88.76 (n)
  • 84.46 (a)
(Bos Taurus)
Mammalia MAGEA11 36
  • 42 (a)
(Canis familiaris)
Mammalia -- 36
  • 43 (a)
(Mus musculus)
Mammalia 4933402E13Rik 36
  • 32 (a)
Species with no ortholog for MAGEC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEC1 Gene

Gene Tree for MAGEC1 (if available)
Gene Tree for MAGEC1 (if available)

Paralogs for MAGEC1 Gene

genes like me logo Genes that share paralogs with MAGEC1: view

Variants for MAGEC1 Gene

Sequence variations from dbSNP and Humsavar for MAGEC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs368437701 -- 141,907,541(+) CTCAG(A/G)GTCCT reference, missense
rs367916501 -- 141,903,320(+) CAGGA(A/C)CAGCC upstream-variant-2KB
rs267606373 other 141,907,086(+) ATCTC(C/T)TCACT reference, missense
rs267606372 other 141,907,079(+) ACTCC(A/C)TATCT missense, reference
rs267606371 other 141,906,636(+) GATTC(C/T)TATGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAGEC1 Gene

Variant ID Type Subtype PubMed ID
nsv483159 CNV Complex 15286789
nsv9985 CNV Gain 18304495
esv2740535 CNV Deletion 23290073
esv2740536 CNV Deletion 23290073
esv2740537 CNV Deletion 23290073
esv1703664 CNV Insertion 17803354
esv2740538 CNV Deletion 23290073

Relevant External Links for MAGEC1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEC1 Gene

Disorders for MAGEC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MAGEC1 Gene in MalaCards »

(2) Diseases for MAGEC1 Gene

(1) University of Copenhagen DISEASES for MAGEC1 Gene

(3) Novoseek inferred disease relationships for MAGEC1 Gene

Disease -log(P) Hits PubMed IDs
melanoma 56.6 3
cancer 27.7 3
tumors 21.6 4

Relevant External Links for MAGEC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MAGEC1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for MAGEC1 Gene

Publications for MAGEC1 Gene

  1. Identification of a new MAGE gene with tumor-specific expression by representational difference analysis. (PMID: 9485030) Lucas S. … Boon T. (Cancer Res. 1998) 2 3 4 23
  2. Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. (PMID: 9618514) Chen Y.-T. … Old L.J. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  3. Cellular immune responses against CT7 (MAGE-C1) and humoral responses against other cancer-testis antigens in multiple myeloma patients. (PMID: 20108890) Lendvai N. … Cho H.J. (Cancer Immun. 2010) 3 23
  4. Expression of cancer-testis antigen CT7 (MAGE-C1) in breast cancer: an immunohistochemical study with emphasis on prognostic utility. (PMID: 17607369) KrA1ger S. … Friedrich M. (Pathol. Oncol. Res. 2007) 3 23
  5. Physical interaction of two cancer-testis antigens, MAGE-C1 (CT7) and NY-ESO-1 (CT6). (PMID: 17137291) Cho H.J. … Simpson A.J. (Cancer Immun. 2006) 3 23

Products for MAGEC1 Gene

Sources for MAGEC1 Gene

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