MAGEC1 Gene
protein-coding GIFtS: 53
GCID: GC0XP140991
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melanoma antigen family C, 1
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Aliases
for MAGEC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family C, 11 2 | | MAGE-C11 | | CT7.11 2 3 | | MGC393661 | | CT71 2 | | Cancer/Testis Antigen Family 7, Member 12 | | Cancer/Testis Antigen 7.12 3 | | Melanoma-Associated Antigen C12 | | MAGE-C1 Antigen2 3 | | |
Export aliases for MAGEC1 gene to outside databasesPrevious GC identifers: GC0XP135521 GC0XP137849 GC0XP138924 GC0XP139685 GC0XP140717 GC0XP140819 GC0XP130087 |
Summaries
for MAGEC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEC1:
This gene is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specificantigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of uniqueshort repetitive sequences in front of the MAGE-homologous sequence, and therefore is about 800 aa longer than theother MAGE proteins. (provided by RefSeq, Jul 2008)
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Genomic Views
for MAGEC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEC1 gene promoter:
AP-2rep p53 ZID NF-kappaB1 LCR-F1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq26 Ensembl cytogenetic band: Xq27.2 HGNC cytogenetic band: Xq26MAGEC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP140991: view genomic region
(about GC identifiers)
Start:
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140,991,642 bp from pter |
End:
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140,997,187 bp from pter |
Size:
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5,546 bases |
Orientation:
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plus strand |
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Proteins
for MAGEC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGC1_HUMAN, O60732 (See
protein sequence)Recommended Name: Melanoma-associated antigen C1 Size: 1142 amino acids; 123643 Da
Secondary accessions: O75451 Q8TCV4Explore the universe of human proteins at neXtProt for MAGEC1: NX_O60732
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60732
MAGEC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005453.2
ENSEMBL proteins: ENSP00000285879 ENSP00000359542 ENSP00000385500
Human Recombinant Protein Products:
MAGEC1 Antibody Products:
Assay Products for MAGEC1: |
Protein
Domains /
Families
for MAGEC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O60732ProtoNet protein and cluster: O60732 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGC1_HUMAN, O60732Similarity: Contains 1 MAGE domain |
Function
for MAGEC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for MAGEC1:melanoma antigen,family C,member 1,expressed in a significant proportion of tumors of various histological types and innormal testis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEC1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEC1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
MAGEC1 for ontologies About GeneDecksing
|
Pathways & Interactions
for MAGEC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/10 Interacting proteins for MAGEC1 (O607321, 3 ENSP000002858794) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for MAGEC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEC1
Search CenterWatch for drugs/clinical trials and news about MAGEC1 / MAGC1
|
Transcripts
for MAGEC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEC1 gene: NM_005462.4 Unigene Cluster for MAGEC1: Melanoma antigen family C, 1 Hs.132194 [show with all ESTs]Unigene Representative Sequence: NM_0054623 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000285879(uc010nsl.2 uc004fbt.3) ENST00000370511 ENST00000406005
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEC1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAGEC1 (NM_005462) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEC1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAGEC1 |
Additional cDNA sequence: AF056334.1 BC127771.1 2 DOTS entries: DT.100742553 DT.40129166 24/32 AceView cDNA sequences (see all 32): BM472698 BE729100 BQ772869 BE728581 CA428538 AI652057 BU167318 BG476223 BM792325 BM787462 AL135051 AL121366 BQ429989 CA428722 BX102175 BV198183 AW515767 AF056334 AI126114 BU619882 BE727610 BE729883 AL121291 BM904844
GeneLoc Exon Structure
|
Expression
for MAGEC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAAAGAATA
About this image
See MAGEC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEC1
SOURCE GeneReport for Unigene cluster: Hs.132194
UniProtKB/Swiss-Prot: MAGC1_HUMAN, O60732Tissue specificity: Expressed in testis and in tumors of a wide variety of histologic types
SABiosciences Custom PCR Arrays for MAGEC1
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MAGEC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEC1 |
Orthologs
for MAGEC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEC1 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
33(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
28(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
21(a) |
1 → many |
3R(2979960-2980898) |
worm
(Caenorhabditis elegans) |
Secernentea |
CELE_Y75B8A.131 |
Protein Y75B8A.13 |
35.52(n)
25.49(a) |
|
176648 NM_067185.2 NP_499586.2 |
ENSEMBL Gene Tree for MAGEC1 (if available)
TreeFam Gene Tree for MAGEC1 (if available) |
Paralogs
for MAGEC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEC1 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGED42 MAGEA82
- MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12 MAGED12
- MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2 MAGEE22
- MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/34 SIMAP similar genes for MAGEC1 using alignment to 3 protein entries: MAGC1_HUMAN (see all proteins)
(see all similar genes):MAGEC4 MAGEC3 MAGEE1 MAGEA11 MAGEC2 MAGEA10
MAGEB16 MAGEB17 MAGEA9 MAGEA13P MAGEB2 MAGE-B1
MAGEA8 MAGEB1 MAGEB10 MAGEB18 MAGEA9B MAGED2
MAGEC1 for paralogs About GeneDecksing
|
Genomic Variants
for MAGEC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEC1 (140991642 - 140997187 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MAGEC1
2 CNVs: 0255 31569
Human Gene Mutation Database (HGMD): MAGEC1
Locus Specific Mutation Databases (LSDB): MAGEC1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEC1 |
|
Disorders
/ Diseases
for MAGEC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEC1 for disorders About GeneDecksing
OMIM gene information: 300223
OMIM disorders: --
8  diseases for MAGEC1: About MalaCardsmelanoma multiple myeloma myeloma leiomyoma
prostate cancer breast cancer prostatitis schizophrenia
1 disease from the University of Copenhagen DISEASES database for MAGEC1:Multiple myeloma 3 Novoseek disease relationships for MAGEC1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: MAGEC1 (1 document)
Export disorders for MAGEC1 gene to outside databases
|
Publications
for MAGEC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEC1 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with MAGEC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a new MAGE gene with tumor-specific expression by representational difference analysis. (PubMed id 9485030)1, 2, 3, 9 Lucas S....Boon T. (1998)
- Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. (PubMed id 9618514)1, 2, 3 Chen Y.T....Old L.J. (1998)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Cellular immune responses against CT7 (MAGE-C1) and h umoral responses against other cancer-testis antigens in multiple myeloma patie nts. (PubMed id 20108890)1, 9 Lendvai N....Cho H.J. (2010)
- Physical interaction of two cancer-testis antigens, MAGE-C1 (CT7) and NY-ESO-1 (CT6). (PubMed id 17137291)1, 9 Cho H.J....Simpson A.J. (2006)
- Expression of cancer-testis antigen CT7 (MAGE-C1) in breast cancer: an immunohistochemical study with emphasis on prognostic utility. (PubMed id 17607369)1, 9 Kruger S....Friedrich M. (2007)
- Expression of MAGE-C1/CT7 and MAGE-C2/CT10 predicts l ymph node metastasis in melanoma patients. (PubMed id 21738656)1 Curioni-Fontecedro A....Moch H. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Targeting MAGE-C1/CT7 expression increases cell sensit ivity to the proteasome inhibitor bortezomib in multiple myeloma cell lines. (PubMed id 22110734)1 de Carvalho F....Colleoni G.W. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
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External Searches for MAGEC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEC1 gene:
Search GeneIP for patents involving MAGEC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for MAGEC1 | | OriGene Custom Protein Services for MAGEC1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAGEC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAGEC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEC1 |
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| | | | Search Tocris compounds for MAGEC1 |
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 | | | MAGEC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEC1 |
|  |  |  | | | | ThermoFisher Antibodies for MAGEC1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAGEC1 |
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