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MAGEB6 Gene

protein-coding   GIFtS: 46
GCID: GC0XP026210

Melanoma Antigen Family B, 6

  Search for MAGEB6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Melanoma Antigen Family B, 61 2     Member 41
Cancer/Testis Antigen 3.42 3     MAGE-B62
CT3.42 3     MAGEB6A2
MAGE-B6 Antigen2 3     Cancer/Testis Antigen Family 3, Member 42
Cancer/Testis Antigen Family 31     Melanoma-Associated Antigen B62

External Ids:    HGNC: 237961   Entrez Gene: 1588092   Ensembl: ENSG000001767467   OMIM: 3004675   UniProtKB: Q8N7X43   

Export aliases for MAGEB6 gene to outside databases

Previous GC identifers: GC0XP024869 GC0XP025412 GC0XP025571 GC0XP025970 GC0XP026120 GC0XP023949


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAGEB6 Gene:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences
located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters
and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene
family enables the same function to be expressed under different transcriptional controls. This gene is expressed
in testis, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered
on chromosome Xp22-p21. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAGEB6 Gene:
MAGEB6 (melanoma antigen family B, 6) is a protein-coding gene. An important paralog of this gene is MAGEC2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAGEB6 gene promoter:
         AhR   PPAR-alpha   Hand1   C/EBPalpha   Arnt   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGEB6 promoter sequence
   Search Chromatin IP Primers for MAGEB6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGEB6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.3   Ensembl cytogenetic band:  Xp21.3   HGNC cytogenetic band: Xp22.12

MAGEB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEB6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP026210:  view genomic region     (about GC identifiers)

Start:
26,210,557 bp from pter      End:
26,213,763 bp from pter
Size:
3,207 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAGB6_HUMAN, Q8N7X4 (See protein sequence)
Recommended Name: Melanoma-associated antigen B6  
Size: 407 amino acids; 43992 Da
Secondary accessions: Q6GS19 Q9H219

Explore the universe of human proteins at neXtProt for MAGEB6: NX_Q8N7X4

Explore proteomics data for MAGEB6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAGEB6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775794.2  
    ENSEMBL proteins: 
     ENSP00000368320  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry Q8N7X4

    ProtoNet protein and cluster: Q8N7X4

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGB6_HUMAN, Q8N7X4
    Similarity: Contains 1 MAGE domain


    Find genes that share domains with MAGEB6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with MAGEB6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAGEB6:
     Decreased TP53 protein express  Increased G1 DNA content 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with MAGEB6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAGEB6
    Interactions:

        Search GeneGlobe Interaction Network for MAGEB6

    1 Interacting protein for MAGEB6 (Q8N7X41) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428581EBI-6447163,EBI-466029
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with MAGEB6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAGEB6 (MAGB6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAGEB6 gene: 
    NM_173523.2  

    Unigene Cluster for MAGEB6:

    Melanoma antigen family B, 6
    Hs.376011  [show with all ESTs]
    Unigene Representative Sequence: BC067286
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000379034(uc004dbr.3)
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    Additional mRNA sequence: 

    AK097561.1 BC067286.1 BC074920.2 

    2 DOTS entries:

    DT.401462  DT.100740565 

    11 AceView cDNA sequences:

    BC074920 NM_173523 AK097561 AL521086 BC067286 CR604094 BX328917 AA913917 
    BX368980 CD359761 AL521085 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAGEB6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAACAGAGA
    MAGEB6 Expression
    About this image

    MAGEB6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAGEB6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.376011

    UniProtKB/Swiss-Prot: MAGB6_HUMAN, Q8N7X4
    Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of
    different histological origins

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MAGEB6 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mageb17-ps1 , 5 melanoma antigen family B, 17, pseudogene1, 5 66.36(n)1
    53.07(a)1
      X (40.45 cM)5
    2368911  XM_141933.31  XP_141933.21 
     916253955 


    ENSEMBL Gene Tree for MAGEB6 (if available)
    TreeFam Gene Tree for MAGEB6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAGEB6 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEB42  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGED12  
    MAGEA22  MAGEA32  MAGEB22  NDN2  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  
    MAGEA102  MAGEB182  MAGEA2B2  MAGEL22  TRO2  MAGEA112  NDNL22  MAGEF12  
    Selected SIMAP similar genes for MAGEB6 using alignment to 1 protein entry:     MAGB6_HUMAN(see all similar genes):
    MAGE-B1    MAGEB1    MAGEA11    MAGEB3    MAGEC4    MAGEB2
    MAGEB4    MAGEB5    MAGEA4    MAGEA13P    MAGEB16    MAGEH1
    MAGEA1    MAGEA8    MAGEA10    MAGEB17    MAGEB18    MAGEA2

    Find genes that share paralogs with MAGEB6           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MAGEB6
    PGOHUM00000241672


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAGEB6 (see all 146)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1874085211,2
    --26123607(+) AATACA/CAGTGT 1 -- us2k10--------
    rs117982481,2
    C,A,H--26123807(+) AATACT/CGAGTA 1 -- us2k14Minor allele frequency- C:0.00WA NA 8
    rs1411419121,2
    --26123891(+) ATTGGC/TGCAAA 1 -- us2k10--------
    rs1114784651,2
    C--26124082(-) TCCTTA/GATGAA 1 -- us2k10--------
    rs2014754781,2
    --26124305(+) AAGAA-/TTTTTT 1 -- us2k10--------
    rs59443551,2
    C,F,A,H--26124315(+) TTTTTT/AAAAAA 1 -- us2k1 trp33Minor allele frequency- A:0.20WA NA 10
    rs750662611,2
    F--26124316(+) TTTTAT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1469462221,2
    --26124395(+) AGAATA/GGGTGT 1 -- us2k10--------
    rs1380152001,2
    C--26124456(+) ACAGAC/TGCAGA 1 -- us2k10--------
    rs1869211091,2
    --26124614(+) TGCCAC/TAGCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAGEB6 (26210557 - 26213763 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MAGEB6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740023CNV Deletion23290073
    esv2677789CNV Deletion23128226
    esv2740022CNV Deletion23290073
    esv2740021CNV Deletion23290073

    Locus Specific Mutation Databases (LSDB): MAGEB6

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300467    OMIM disorders: --


    Find genes that share disorders with MAGEB6           About GenesLikeMe


    Export disorders for MAGEB6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAGEB6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MAGEB6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PubMed id 10861452)1, 2, 3 Lucas S.... Boon T. (Int. J. Cancer 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 158809 HGNC: 23796 AceView: MAGEB6 Ensembl:ENSG00000176746 euGenes: HUgn158809
    ECgene: MAGEB6 H-InvDB: MAGEB6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAGEB6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEB6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAGEB6 gene:
    Search GeneIP for patents involving MAGEB6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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