MAGEB6 Gene
protein-coding GIFtS: 45
GCID: GC0XP026210
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|
melanoma antigen family B, 6
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Aliases
for MAGEB6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family B, 61 2 | | MAGE-B6 Antigen2 3 | | CT3.41 2 3 | | FLJ402421 | | MAGE-B61 2 | | Cancer/Testis Antigen Family 3, Member 42 | | MAGEB6A1 2 | | Melanoma-Associated Antigen B62 | | Cancer/Testis Antigen 3.42 3 | | |
Export aliases for MAGEB6 gene to outside databasesPrevious GC identifers: GC0XP024869 GC0XP025412 GC0XP025571 GC0XP025970 GC0XP026120 GC0XP023949 |
Summaries
for MAGEB6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEB6:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences locatedin the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and firstexons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables thesame function to be expressed under different transcriptional controls. This gene is expressed in testis, and in asignificant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21.(provided by RefSeq, Jul 2008)
|
Genomic Views
for MAGEB6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEB6 gene promoter:
AhR PPAR-alpha Hand1 C/EBPalpha Arnt E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEB6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEB6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp21.3 Ensembl cytogenetic band: Xp21.3 HGNC cytogenetic band: Xp22.12MAGEB6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP026210: view genomic region
(about GC identifiers)
Start:
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26,210,557 bp from pter |
End:
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26,213,763 bp from pter |
Size:
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3,207 bases |
Orientation:
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plus strand |
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Proteins
for MAGEB6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGB6_HUMAN, Q8N7X4 (See
protein sequence)Recommended Name: Melanoma-associated antigen B6 Size: 407 amino acids; 43992 Da
Secondary accessions: Q6GS19 Q9H219Explore the universe of human proteins at neXtProt for MAGEB6: NX_Q8N7X4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N7X4
MAGEB6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775794.2
ENSEMBL proteins: ENSP00000368320
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
MAGEB6 for ontologies About GeneDecksing
MAGEB6 Antibody Products:
Assay Products for MAGEB6: |
Protein
Domains /
Families
for MAGEB6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEB6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N7X4ProtoNet protein and cluster: Q8N7X4 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGB6_HUMAN, Q8N7X4Similarity: Contains 1 MAGE domain |
Function
for MAGEB6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB6
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
MAGEB6 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MAGEB6:
|
Pathways & Interactions
for MAGEB6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEB6
1 Interacting protein for MAGEB6 (Q8N7X41) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
MAGEB6 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAGEB6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEB6
Search CenterWatch for drugs/clinical trials and news about MAGEB6 / MAGB6
|
Transcripts
for MAGEB6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEB6 gene: NM_173523.2 Unigene Cluster for MAGEB6: Melanoma antigen family B, 6 Hs.376011 [show with all ESTs]Unigene Representative Sequence: BC0672861 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000379034(uc004dbr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB6
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAGEB6 (NM_173523) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEB6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEB6 |
Additional cDNA sequence: AK097561.1 BC067286.1 BC074920.2 2 DOTS entries: DT.401462 DT.100740565 11 AceView cDNA sequences: BC074920 NM_173523 CR604094 BC067286 BX328917 AK097561 AL521086 BX368980 AA913917 CD359761 AL521085
GeneLoc Exon Structure
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Expression
for MAGEB6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEB6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTAACAGAGA
About this image
See MAGEB6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEB6
SOURCE GeneReport for Unigene cluster: Hs.376011
UniProtKB/Swiss-Prot: MAGB6_HUMAN, Q8N7X4Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of differenthistological origins
SABiosciences Custom PCR Arrays for MAGEB6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEB6
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB6 |
Orthologs
for MAGEB6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEB6 gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
35(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
27(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
23(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEB6 (if available)
TreeFam Gene Tree for MAGEB6 (if available) |
Paralogs
for MAGEB6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEB6 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGEA82 MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12
- MAGED12 MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2
- MAGEE22 MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/37 SIMAP similar genes for MAGEB6 using alignment to 1 protein entry: MAGB6_HUMAN(see all similar genes):MAGE-B1 MAGEB1 MAGEA11 MAGEB3 MAGEC4 MAGEB2
MAGEB4 MAGEB5 MAGEA4 MAGEA13P MAGEB16 MAGEH1
MAGEA1 MAGEA8 MAGEA10 MAGEB17 MAGEB18 MAGEA2
MAGEB6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MAGEB6
PGOHUM00000241672
|
Genomic Variants
for MAGEB6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEB6 (26210557 - 26213763 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAGEB6: --
Locus Specific Mutation Databases (LSDB): MAGEB6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEB6 |
|
Disorders
/ Diseases
for MAGEB6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEB6 for disorders About GeneDecksing
OMIM gene information: 300467
OMIM disorders: --
1  disease for MAGEB6: About MalaCardsmelanoma
Export disorders for MAGEB6 gene to outside databases
|
Publications
for MAGEB6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEB6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAGEB6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PubMed id 10861452)1, 2, 3 Lucas S.... Boon T. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MAGEB6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEB6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEB6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEB6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEB6 gene:
Search GeneIP for patents involving MAGEB6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEB6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | MAGEB6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB6 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEB6 |
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