 |
 | Services
| |
 |
Aliases &
Descriptions
for MAGEB6
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| CT3.4 1, 2, 3 | | FLJ40242 1, 2 | | MAGE-B6 1, 2 | | MAGEB6A 1, 2 | | OTTHUMP00000023093 2 |
| | | Descriptions |
|---|
| Cancer/testis antigen 3.4 3 | | MAGE-B6 antigen 3 | | cancer/testis antigen family 3, member 4 2 | | melanoma antigen family B, 6 2 |
|
| |
Search outside databases for aliases for MAGEB6 genePrevious GC identifers: GC0XP024869 GC0XP025412 GC0XP025571 GC0XP025970 |
Summaries
for MAGEB6(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for MAGEB6:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding
sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to
each other. The promoters and first exons of the MAGEB genes show considerable variability,
suggesting that the existence of this gene family enables the same function to be expressed under
different transcriptional controls. This gene is expressed in testis, and in a significant
fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome
Xp22-p21. [provided by RefSeq]
|
Genomic Location
for MAGEB6
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the MAGEB6 gene 
Entrez Gene cytogenetic band: Xp21.3 Ensembl cytogenetic band: Xp21.3 HGNC cytogenetic band: Xp22.12MAGEB6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP026120:
(about GC identifiers)
Start:
|
26,120,478 bp from pter |
End:
|
26,123,684 bp from pter |
Size:
|
3,207 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011757.15
| Proteins
for MAGEB6
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MAGB6_HUMAN, Q8N7X4 (See
protein sequence)Recommended Name: Melanoma-associated antigen B6 Size: 407 amino acids; 43992 Da
Secondary accessions: Q6GS19 Q9H219REFSEQ proteins: NP_775794.2
ENSEMBL proteins: ENSP00000368320 ENSP00000380696
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
About this table
Antibodies for MAGEB6:
Assays for MAGEB6: | Protein
Domains/
Families
for MAGEB6(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8N7X4
ProtoNet protein and cluster: Q8N7X4 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGB6_HUMAN, Q8N7X4Similarity: Contains 1 MAGE domain | Gene Function
for MAGEB6
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173523
 Applied Biosystems Silencer® siRNAs for MAGEB6
 Sigma-Aldrich siRNA for MAGEB6
Sigma-Aldrich shRNA for MAGEB6
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_173523
Myc/DDK tagged cDNA clone in CMV expression vector: NM_173523
untagged cDNA clones in CMV expression vector (see all 2): NM_173523
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_173523
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
About this table | Pathways & Interactions
for MAGEB6
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
--1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
About this table
|
Drugs & Compounds
for MAGEB6(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for MAGEB6
|
Transcripts
for MAGEB6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173523
Sigma-Aldrich siRNA for MAGEB6
Sigma-Aldrich shRNA for MAGEB6
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_173523 REFSEQ mRNAs for MAGEB6 gene: NM_173523.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_173523
OriGene GFP tagged cDNA clone in CMV expression vector: NM_173523
Myc/DDK tagged cDNA clone in CMV expression vector: NM_173523
untagged cDNA clones in CMV expression vector (see all 2): NM_173523
Additional cDNA sequence: AK097561.1 BC067286.1 BC074920.2 CR604094.1 2 DOTS entries: DT.401462 DT.100740565 11 AceView cDNA sequences:NM_173523 BC074920 BC067286 CR604094 AL521086 AK097561 BX328917 AA913917 BX368980 CD359761 AL521085
 highest scoring ESTs for MAGEB6:AA913917 AK097561 BC067286 CD359761 AA758924 AL521086 BC074920 BX368980 NM_173523 CR604094 Unigene Cluster for MAGEB6: Melanoma antigen family B, 6 Hs.376011 [show with all ESTs]Unigene Representative Sequence: BC067286
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000379034
ENST00000397565
|
Expression
for MAGEB6
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MAGEB6 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MAGEB6
1 / 2 1 probe-set matching MAGEB6 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTAACAGAGA
SOURCE GeneReport for Unigene cluster: Hs.376011
UniProtKB/Swiss-Prot: MAGB6_HUMAN, Q8N7X4Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in
tumors of different histological origins |
Orthologs
for MAGEB6
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MAGEB6 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
MAGEB61 |
-- |
melanoma antigen family B, 6 |
97.99(n)
95.34(a) |
473542 XM_528913.2 XP_528913.1 |
About this table Species with no ortholog for MAGEB6
ENSEMBL Gene Tree for MAGEB6 | Paralogs
for MAGEB6(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MAGEB6 gene
- MAGEB172 MAGEB12 MAGEB42 MAGEB22
|
SNPs/Variants
for MAGEB6(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for MAGEB6 (up to first 250kb)
|
Disorders & Mutations
for MAGEB6
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300467
|
Medical News
for MAGEB6(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MAGEB6 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 4 PubMed articles for MAGEB6 gene:- MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PubMed id 10861452)2, 3, 4 Lucas S.... Boon T. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for MAGEB6
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEB6
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MAGEB6
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEB6(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for MAGEB6(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for MAGEB6:
 | |
 | | | | |
 |
 |  |  | |
| | |  | Search Tocris compounds for MAGEB6 |
|
 |
 | | |
|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|
V3 here soon-try beta now
