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Aliases for MAGEB6 Gene

Aliases for MAGEB6 Gene

  • Melanoma Antigen Family B6 2 3
  • Cancer/Testis Antigen 3.4 3 4
  • MAGE-B6 Antigen 3 4
  • CT3.4 3 4
  • Cancer/Testis Antigen Family 3, Member 4 3
  • Cancer/Testis Antigen Family 3 2
  • Melanoma-Associated Antigen B6 3
  • Melanoma Antigen Family B, 6 3
  • Member 4 2
  • MAGE-B6 3
  • MAGEB6A 3

External Ids for MAGEB6 Gene

Previous GeneCards Identifiers for MAGEB6 Gene

  • GC0XP024869
  • GC0XP025412
  • GC0XP025571
  • GC0XP025970
  • GC0XP026120
  • GC0XP023949

Summaries for MAGEB6 Gene

Entrez Gene Summary for MAGEB6 Gene

  • This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is expressed in testis, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEB6 Gene

MAGEB6 (Melanoma Antigen Family B6) is a Protein Coding gene. An important paralog of this gene is MAGED1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB6 Gene

Genomics for MAGEB6 Gene

Regulatory Elements for MAGEB6 Gene

Genomic Location for MAGEB6 Gene

Start:
26,192,440 bp from pter
End:
26,195,646 bp from pter
Size:
3,207 bases
Orientation:
Plus strand

Genomic View for MAGEB6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB6 Gene

Proteins for MAGEB6 Gene

  • Protein details for MAGEB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7X4-MAGB6_HUMAN
    Recommended name:
    Melanoma-associated antigen B6
    Protein Accession:
    Q8N7X4
    Secondary Accessions:
    • Q6GS19
    • Q9H219

    Protein attributes for MAGEB6 Gene

    Size:
    407 amino acids
    Molecular mass:
    43992 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEB6 Gene

Proteomics data for MAGEB6 Gene at MOPED

Post-translational modifications for MAGEB6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEB6 Gene

Domains for MAGEB6 Gene

Protein Domains for MAGEB6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7X4

UniProtKB/Swiss-Prot:

MAGB6_HUMAN :
  • Q8N7X4
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEB6: view

No data available for Gene Families for MAGEB6 Gene

Function for MAGEB6 Gene

Gene Ontology (GO) - Molecular Function for MAGEB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 23275563
genes like me logo Genes that share ontologies with MAGEB6: view

Phenotypes for MAGEB6 Gene

genes like me logo Genes that share phenotypes with MAGEB6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEB6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MAGEB6 Gene

Localization for MAGEB6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEB6 Gene COMPARTMENTS Subcellular localization image for MAGEB6 gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MAGEB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAGEB6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAGEB6 Gene

Pathways for MAGEB6 Gene

SuperPathways for MAGEB6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEB6: view

No data available for Pathways by source for MAGEB6 Gene

Transcripts for MAGEB6 Gene

mRNA/cDNA for MAGEB6 Gene

(11) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB6 Gene

Melanoma antigen family B, 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEB6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB6 Gene

No ASD Table

Relevant External Links for MAGEB6 Gene

GeneLoc Exon Structure for
MAGEB6
ECgene alternative splicing isoforms for
MAGEB6

Expression for MAGEB6 Gene

mRNA expression in normal human tissues for MAGEB6 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEB6 Gene

This gene is overexpressed in Testis (52.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAGEB6 Gene

SOURCE GeneReport for Unigene cluster for MAGEB6 Gene Hs.376011

mRNA Expression by UniProt/SwissProt for MAGEB6 Gene

Q8N7X4-MAGB6_HUMAN
Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different histological origins.
genes like me logo Genes that share expressions with MAGEB6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGEB6 Gene

Orthologs for MAGEB6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEB6 35
  • 97.99 (n)
  • 95.34 (a)
MAGEB6 36
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 44 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm5072 36
  • 35 (a)
OneToMany
Gm8914 36
  • 35 (a)
OneToMany
Mageb1 36
  • 37 (a)
OneToMany
Mageb17-ps 35
  • 66.36 (n)
  • 53.07 (a)
Mageb17-ps 16
Mageb2 36
  • 37 (a)
OneToMany
Mageb3 36
  • 44 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mageb6 35
  • 65.81 (n)
  • 50 (a)
Species with no ortholog for MAGEB6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB6 Gene

ENSEMBL:
Gene Tree for MAGEB6 (if available)
TreeFam:
Gene Tree for MAGEB6 (if available)

Paralogs for MAGEB6 Gene

Pseudogenes.org Pseudogenes for MAGEB6 Gene

genes like me logo Genes that share paralogs with MAGEB6: view

Variants for MAGEB6 Gene

Sequence variations from dbSNP and Humsavar for MAGEB6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4272533 -- 26,194,145(+) TGATG(C/T)CTCCG reference, missense
rs4351548 -- 26,194,134(+) AGCAC(C/T)TCCCG reference, synonymous-codon
rs4630029 -- 26,194,139(+) CTCCC(A/G)TGATG missense, reference
rs4997767 -- 26,194,188(+) GGCTC(G/T)CCTGA synonymous-codon, reference
rs5944355 -- 26,191,178(+) TTTTT(A/T)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAGEB6 Gene

Variant ID Type Subtype PubMed ID
esv2740021 CNV Deletion 23290073
esv2740022 CNV Deletion 23290073
esv2740023 CNV Deletion 23290073
esv2677789 CNV Deletion 23128226

Relevant External Links for MAGEB6 Gene

HapMap Linkage Disequilibrium report
MAGEB6
Locus Specific Mutation Databases (LSDB)
MAGEB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEB6 Gene

Disorders for MAGEB6 Gene

No disorders were found for MAGEB6 Gene.

No data available for UniProtKB/Swiss-Prot for MAGEB6 Gene

Publications for MAGEB6 Gene

  1. MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PMID: 10861452) Lucas S. … Boon T. (Int. J. Cancer 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3

Products for MAGEB6 Gene

  • antibodies-online proteins for MAGEB6
  • antibodies-online antibodies for MAGEB6
  • antibodies-online kits for MAGEB6

Sources for MAGEB6 Gene

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