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MAGEB5 Gene

protein-coding   GIFtS: 37

GC0XP026144
melanoma antigen family B, 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CT3.3 1, 2, 3
MAGE-B5 1, 2
Descriptions
Cancer/testis antigen 3.3 3
MAGE family testis and tumor-specific protein 2
MAGE-B5 antigen 3
cancer/testis antigen family 3, member 3 2
melanoma antigen family B, 5 2
External Ids
HGNC: 237951
Entrez Gene: 3475412
UniProtKB: Q9BZ813
Ensembl: ENSG000001884087
Search outside databases for aliases for MAGEB5 gene

Previous GC identifers: GC0XU900004 GC0XP025596 GC0XP025995

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MAGEB5 gene  

Entrez Gene cytogenetic band: Xp21.3   Ensembl cytogenetic band:  Xp21.3   HGNC cytogenetic band: Xp22

MAGEB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP026144:     (about GC identifiers)

Start:
26,144,178 bp from pter
End:
26,146,308 bp from pter
Size:
2,131 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000023.9  NT_011757.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MAGB5_HUMAN, Q9BZ81 (See protein sequence)
Recommended Name: Melanoma-associated antigen B5  
Size: 275 amino acids; 31906 Da



ENSEMBL proteins: 
ENSP00000368315 ENSP00000343373 


Human Recombinant Proteins 
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Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005575 cellular_component ND--
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Antibodies for MAGEB5: 
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Search Novus for antibodies for MAGEB5

Assays for MAGEB5: 
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Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR002190 MAGE


   GeneDecks  MAGEB5 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9BZ81

ProtoNet protein and cluster: Q9BZ81

UniProtKB/Swiss-Prot: MAGB5_HUMAN, Q9BZ81
Similarity: Contains 1 MAGE domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (MAGEB5)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for MAGEB5

              Sigma-Aldrich siRNA for MAGEB5  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                Browse Origene for untagged/tagged cDNA clones in CMV expression vector

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                Browse Origene genome-wide validated SYBR primer pairs

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003674 molecular_function ND--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008150 biological_process ND--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGEB5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (MAGEB5)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Sigma-Aldrich siRNA for MAGEB5  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

XM_293407  

                Browse Origene for untagged/tagged cDNA clones in CMV expression vector

Additional cDNA sequence: XM_293407.6 

1 DOTS entry:

DT.75134306 

2 AceView cDNA sequences:

AI954607 BE552290 

highest scoring ESTs for MAGEB5:

AI954607 BE552290 CR747535 AL133110 XM_293407 

Unigene Cluster for MAGEB5:

Melanoma antigen family B, 5
Hs.224079  [show with all ESTs]
Unigene Representative Sequence: XM_293407


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000379029  ENST00000344732  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MAGEB5 expression in normal and diseased human tissues

1 / 3Data from (Publications) and GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.224079

UniProtKB/Swiss-Prot: MAGB5_HUMAN, Q9BZ81
Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in
tumors of different histological origins

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for MAGEB5 gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
MAGEB51   -- melanoma antigen family B, 5 71.63(n)
57.95(a)
480870  XM_537986.2  XP_537986.2 
cow
(Bos taurus)
MAGEB51   -- melanoma antigen family B, 5 75.27(n)
63.44(a)
782551  XM_001251181.1  XP_001251182.1 
rat
(Rattus norvegicus)
Mageb51   -- melanoma antigen, family B, 5 70(n)
55.45(a)
302442  XM_228606.1  XP_228606.1 
mouse
(Mus musculus)
Mageb51, 5 X5
melanoma antigen, family B, 51, 5 64.55(n)1
49.25(a)1
742711  XM_284719.31  XP_284719.11 
 AC0258745  AK0068075  (see all 8)
About this table        Species with no ortholog for MAGEB5

ENSEMBL Gene Tree for MAGEB5
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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Paralogs for MAGEB5 gene
MAGEB32  MAGEB162  MAGEB102  MAGEB182  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/17 NCBI SNPs in MAGEB5 are shown (see all 17 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 37)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs21907381,2
A,C,F,H,O26142566(-) TAAACT/GTTGGG 1 -- ng518Minor allele frequency- G:0.32EU EA WA NA 632
rs18600121,2
A,C,F,H26142802(-) TTTGAA/GGTAGT 1 -- ng517Minor allele frequency- G:0.20EU EA WA NA 558
rs59443601,2
A,C,F,H26143119(+) TTTTTT/CTCTCT 1 -- ng51 trp34Minor allele frequency- C:0.02EU EA WA 418
rs59865921,2
C,F,H26146733(+) TGAGGC/TTATGA 1 -- ng317Minor allele frequency- T:0.25EU EA WA NA 558
rs173438441,2
F,H26144114(+) CTAGAG/AGATTT 1 -- ng517Minor allele frequency- A:0.20NA EU EA WA 530
rs14767241,2
F26143098(-) AAACCA/GTTGCT 1 -- ng513Minor allele frequency- G:0.22NA EA 252
rs128439841,2
H26143166(+) CTTCAG/AATTTC 1 -- ng514Minor allele frequency- A:0.00EU EA WA 414
--
rs720280601,2
--26143116(+) TTTTT-/TTTTTCT 1 -- ng510--------
--
rs30545181,2
--26143106(-) AAAAA-/AAGAAAA 1 -- ng510--------
--
rs350988681,2
--26142459(+) TATTT-/GGGAGT 1 -- ng510--------
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HapMap Linkage Disequilibrium images for MAGEB5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300466

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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2 PubMed articles for MAGEB5 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 347541 HGNC: 23795 AceView: MAGEB5 Ensembl:ENSG00000188408 euGenes: HUgn347541
ECgene: MAGEB5 H-InvDB: MAGEB5
(According to HUGE)
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  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for MAGEB5 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for MAGEB5:
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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