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MAGEB4 Gene

protein-coding GIFtS: 53

GC0XP030171

melanoma antigen family B, 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CT3.6 ^¹, ²
MGC33144 ^¹, ²

Descriptions
MAGE-B4 antigen ^³
cancer/testis antigen family 3, member 6 ^²
melanoma antigen family B, 4 ^²
melanoma-associated antigen B4 ^²

External Ids
HGNC: 6811¹
Entrez Gene: 4115²
UniProtKB: O15481³
Ensembl: ENSG00000120289⁷

Search outside databases for aliases for MAGEB4 gene

Previous GC identifers: GC0XP028759 GC0XP028943 GC0XP029462 GC0XP029621 GC0XP030019

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAGEB4:

This gene is a member of the MAGEB gene family. The members of this family have their entire coding

sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to

each other. The promoters and first exons of the MAGEB genes show considerable variability,

suggesting that the existence of this gene family enables the same function to be expressed under

different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21. This

gene sequence ends in the first intron of MAGEB1, another family member. This gene is expressed in

testis. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAGEB4 gene

Entrez Gene cytogenetic band: Xp21.3 Ensembl cytogenetic band: Xp21.2 HGNC cytogenetic band: Xp21.3

MAGEB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP030171: (about GC identifiers)

Start:	30,170,090 bp from pter
End:	30,172,231 bp from pter
Size:	2,142 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011757.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MAGB4_HUMAN, O15481 (See protein sequence)

Recommended Name: Melanoma-associated antigen B4

Size: 346 amino acids; 38923 Da

Secondary accessions: Q6FHH4 Q8IZ00

REFSEQ proteins: NP_002358.1

ENSEMBL proteins:

ENSP00000368266

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MAGEB4)
	Human Recombinant Proteins from Abnova (MAGEB4)

OriGene Purified Recombinant Human Protein: MAGEB4

Antibodies for MAGEB4:

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	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MAGEB4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAGEB4)
	Search Novus for antibodies for MAGEB4

Assays for MAGEB4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15481

ProtoNet protein and cluster: O15481

1 Blocks protein family: IPB002190 MAGE protein

UniProtKB/Swiss-Prot: MAGB4_HUMAN, O15481

Similarity: Contains 1 MAGE domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGEB4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002367

Applied Biosystems Silencer® siRNAs for MAGEB4

Sigma-Aldrich siRNA for MAGEB4

Sigma-Aldrich shRNA for MAGEB4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MAGEB4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002367
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002367
untagged cDNA clone in CMV expression vector: NM_002367

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002367

Genatlas biochemistry entry for MAGEB4:

melanoma antigen,family B,member 4,expressed in testis

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGEB4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGEB4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002367

Sigma-Aldrich siRNA for MAGEB4

Sigma-Aldrich shRNA for MAGEB4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002367

REFSEQ mRNAs for MAGEB4 gene:

NM_002367.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002367

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002367
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002367
                                 untagged cDNA clone in CMV expression vector: NM_002367

Additional cDNA sequence:

AK313769.1 BC032852.2 CR541779.1

1 DOTS entry:

DT.95163779

24 AceView cDNA sequences:

CR541762 BU189320 NM_177415 NM_177404 NM_002367 BU166425 BQ428314 BI831285

BC013772 BF979409 BE897525 BX105170 X82539 AA634391 BC032852 BI460724

NM_002363 BI826827 CR541779 BG719131 AA412095 BG493595 BF980356 BQ216792

highest scoring ESTs for MAGEB4:

AA634391 BC032852 BF980356 BX280791 DB336182 BF979409 BI460724 NM_002367 DB023175 DB032949

Unigene Cluster for MAGEB4:

Melanoma antigen family B, 4

Hs.113291 [show with all ESTs]

Unigene Representative Sequence: BC032852

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB4

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c
SP1:									-		-
SP2:									-
SP3:							-		-		-
SP4:											-
SP5:

About this scheme

ECgene alternative splicing isoforms for MAGEB4

1 Ensembl transcript including schematic representation:

ENST00000378982

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MAGEB4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAGEB4

¹ / ² / ³

5 probe-sets matching MAGEB4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31582_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	U93163	0.20	0.33	0.27	1
207580_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002367	0.60	0.83	0.73	1
207581_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002367	0.60	0.83	0.73	1
207580_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207581_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATAACATAT

SOURCE GeneReport for Unigene cluster: Hs.113291
Expression variation in blood from EXPOLDB for MAGEB4
UniProtKB/Swiss-Prot: MAGB4_HUMAN, O15481
Tissue specificity: Expressed in testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAGEB4 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	MAGEB4¹	--	melanoma antigen family B, 4	99.33(n) 98.55(a)	473548 XM_528920.2 XP_528920.1
cow (Bos taurus)	MGC133764¹	--	melanoma antigen family B-like	71.96(n) 58.57(a)	788454 XM_001255511.1 XP_001255512.1
rat (Rattus norvegicus)	RGD1565746¹	--	similar to Melanoma-associated antigen B1 (MAGE-B1 more	65.58(n) 50.89(a)	302748 XM_229040.4 XP_229040.4

About this table Species with no ortholog for MAGEB4

ENSEMBL Gene Tree for MAGEB4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAGEB4 gene

MAGEB17² MAGEB6² MAGEB1² MAGEB2²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/13 NCBI SNPs in MAGEB4 are shown (see all 13 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 40)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2158945^1,2	A,C,F,H	30169113(+)	`gtccaC/Tcagca`	1	--	ng5¹		4		EU EA WA	418
	rs2529558^1,2	A,C,F,H	30168125(+)	`CTATCT/AGATCT`	1	--	ng5¹ tfbs³		3		EA WA	298
	rs1573631^1,2	H	30169267(+)	`atcatT/Gtcatg`	1	--	ng5¹		4		EU EA WA	420
--	rs2529560^1,2	--	30168685(+)	`aacctG/Ttggaa`	1	--	ng5¹		0	--	--	--	--
--	rs73205833^1,2	--	30168554(+)	`TGCTGC/TACATT`	1	--	ng5¹		0	--	--	--	--
--	rs2529561^1,2	--	30168782(+)	`ttggcC/Ttcttt`	1	--	ng5¹		0	--	--	--	--
--	rs5901946^1,2	--	30168334(+)	`ATCAC-/TTTTTT`	1	--	ng5¹ trp³		0	--	--	--	--
--	rs2529562^1,2	--	30169086(+)	`ttcaaA/Gagtgg`	1	--	ng5¹		0	--	--	--	--
--	rs63311160^1,2	--	30168335(+)	`TCACT-/TTTTTT`	1	--	ng5¹		0	--	--	--	--
--	rs58637485^1,2	--	30168345(+)	`TTTTT-/TAATAA`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for MAGEB4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300153

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for MAGEB4 gene:

Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PubMed id 9441743)^{2, 3, 4} Lurquin C....Boon T. (1997)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Comparative plasma proteome analysis of lymphoma-bearing SJL mice. (PubMed id 16212437)¹ Bhat V.B....Tannenbaum S.R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4115	HGNC: 6811	AceView: MAGEB1	Ensembl:ENSG00000120289	euGenes: HUgn4115
ECgene: MAGEB4	H-InvDB: MAGEB4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for MAGEB4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MAGEB4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MAGEB4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAGEB4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAGEB4		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for MAGEB4		Browse small molecules at Sigma-Aldrich
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
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	shRNA in GFP-retroviral vector

Search Tocris compounds for MAGEB4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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MAGEB4 Gene

protein-coding GIFtS: 53

Aliases &
Descriptions
for MAGEB4

Summaries
for MAGEB4

Genomic Location
for MAGEB4

Proteins
for MAGEB4

Protein Domains/
Families
for MAGEB4

Gene Function
for MAGEB4

Pathways & Interactions
for MAGEB4

Drugs & Compounds
for MAGEB4

Transcripts
for MAGEB4

Expression
for MAGEB4

Orthologs
for MAGEB4

Paralogs
for MAGEB4

SNPs/Variants
for MAGEB4

Disorders & Mutations
for MAGEB4

Medical News
for MAGEB4

Publications
for MAGEB4

Search for MAGEB4

Genome Databases showing MAGEB4

Other Databases showing MAGEB4

Specialized Databases showing MAGEB4

Licensable Technologies
for MAGEB4

Services
for MAGEB4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAGEB4 Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor MAGEB4

Summariesfor MAGEB4

Genomic Locationfor MAGEB4

Proteinsfor MAGEB4

Protein Domains/Familiesfor MAGEB4

Gene Functionfor MAGEB4

Pathways & Interactionsfor MAGEB4

Drugs & Compoundsfor MAGEB4

Transcriptsfor MAGEB4

Expression for MAGEB4

Orthologsfor MAGEB4

Paralogsfor MAGEB4

SNPs/Variantsfor MAGEB4

Disorders & Mutationsfor MAGEB4

Medical Newsfor MAGEB4

Publicationsfor MAGEB4

Search for MAGEB4

Genome Databases showing MAGEB4

Other Databases showing MAGEB4

Specialized Databases showing MAGEB4

Licensable Technologiesfor MAGEB4

Servicesfor MAGEB4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAGEB4

Summaries
for MAGEB4

Genomic Location
for MAGEB4

Proteins
for MAGEB4

Protein Domains/
Families
for MAGEB4

Gene Function
for MAGEB4

Pathways & Interactions
for MAGEB4

Drugs & Compounds
for MAGEB4

Transcripts
for MAGEB4

Expression
for MAGEB4

Orthologs
for MAGEB4

Paralogs
for MAGEB4

SNPs/Variants
for MAGEB4

Disorders & Mutations
for MAGEB4

Medical News
for MAGEB4

Publications
for MAGEB4

Licensable Technologies
for MAGEB4

Services
for MAGEB4