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MAGEB4 Gene

protein-coding   GIFtS: 50
GCID: GC0XP030260

Melanoma Antigen Family B, 4

  See MAGEB4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Melanoma Antigen Family B, 41 2     Member 61
Melanoma-Associated Antigen B41 2     CT3.62
MAGE-B4 Antigen2 3     Cancer/Testis Antigen Family 3, Member 62
Cancer/Testis Antigen Family 31     

External Ids:    HGNC: 68111   Entrez Gene: 41152   Ensembl: ENSG000001202897   OMIM: 3001535   UniProtKB: O154813   

Export aliases for MAGEB4 gene to outside databases

Previous GC identifers: GC0XP028759 GC0XP028943 GC0XP029462 GC0XP029621 GC0XP030019 GC0XP030171 GC0XP027996


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAGEB4 Gene:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences
located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters
and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene
family enables the same function to be expressed under different transcriptional controls. The MAGEB genes are
clustered on chromosome Xp22-p21. This gene sequence ends in the first intron of MAGEB1, another family member.
This gene is expressed in testis. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAGEB4 Gene:
MAGEB4 (melanoma antigen family B, 4) is a protein-coding gene. Diseases associated with MAGEB4 include melanoma. An important paralog of this gene is MAGEC2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAGEB4 gene promoter:
         NF-kappaB2   ARP-1   RelA   NF-kappaB   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MAGEB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGEB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.3   Ensembl cytogenetic band:  Xp21.2   HGNC cytogenetic band: Xp21.3

MAGEB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEB4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP030260:  view genomic region     (about GC identifiers)

Start:
30,260,057 bp from pter      End:
30,262,310 bp from pter
Size:
2,254 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MAGB4_HUMAN, O15481 (See protein sequence)
Recommended Name: Melanoma-associated antigen B4  
Size: 346 amino acids; 38923 Da
Secondary accessions: B2R9G0 Q6FHH4 Q8IZ00

Explore the universe of human proteins at neXtProt for MAGEB4: NX_O15481

Explore proteomics data for MAGEB4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys284
  • Modification sites at PhosphoSitePlus

  • See MAGEB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002358.1  
    ENSEMBL proteins: 
     ENSP00000368266  

    MAGEB4 Human Recombinant Protein Products:

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    antibodies-online proteins for MAGEB4 (3 products) 

     
    antibodies-online peptides for MAGEB4

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    antibodies-online antibodies for MAGEB4 (18 products) 

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    antibodies-online kits for MAGEB4 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry O15481

    ProtoNet protein and cluster: O15481

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGB4_HUMAN, O15481
    Similarity: Contains 1 MAGE domain


    Find genes that share domains with MAGEB4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for MAGEB4:
    melanoma antigen,family B,member 4,expressed in testis

    Phenotypes:
         1 GenomeRNAi human phenotype for MAGEB4:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MAGEB4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAGEB4
    Interactions:

        Search GeneGlobe Interaction Network for MAGEB4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for MAGEB4 (O154813 ENSP000003682664) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FTSJ3Q8IY813I2D: score=3 
    CYP2D6P106353I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    --ENSP000003375184STRING: ENSP00000337518
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAGEB4 (MAGB4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAGEB4 gene: 
    NM_002367.3  

    Unigene Cluster for MAGEB4:

    Melanoma antigen family B, 4
    Hs.113291  [show with all ESTs]
    Unigene Representative Sequence: NM_002367
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000378982(uc004dcb.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MAGEB4
      QuantiFast Probe-based Assays in human, mouse, rat MAGEB4

    Additional mRNA sequence: 

    AK313769.1 BC032852.2 CR541779.1 

    1 DOTS entry:

    DT.95163779 

    24 AceView cDNA sequences:

    NM_002367 NM_177415 CR541762 BU189320 BQ428314 BU166425 NM_177404 BI826827 
    BC032852 AA634391 BI460724 BI831285 X82539 BC013772 NM_002363 BF979409 
    CR541779 BX105170 BE897525 BG719131 BG493595 AA412095 BF980356 BQ216792 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                          -     -                     
    SP2:                          -                           
    SP3:                    -     -     -                     
    SP4:                                -                     
    SP5:                                                      


    ECgene alternative splicing isoforms for MAGEB4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAGEB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAACATAT
    MAGEB4 Expression
    About this image

    MAGEB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAGEB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.113291

    UniProtKB/Swiss-Prot: MAGB4_HUMAN, O15481
    Tissue specificity: Expressed in testis

        Custom PCR Arrays for MAGEB4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MAGEB4 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mageb25 melanoma antigen, family B, 2   --   X (40.35 cM) 91331755 


    ENSEMBL Gene Tree for MAGEB4 (if available)
    TreeFam Gene Tree for MAGEB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAGEB4 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEC12  MAGED42  MAGEA82  
    MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGED12  MAGEA22  
    MAGEA32  MAGEB22  NDN2  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  MAGEA102  
    MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  MAGEA112  NDNL22  MAGEF12  
    Selected SIMAP similar genes for MAGEB4 using alignment to 1 protein entry:     MAGB4_HUMAN(see all similar genes):
    MAGE-B1    MAGEB1    MAGEB2    MAGEB10    MAGEB17    MAGEB18
    MAGEB3    MAGEB16    MAGEB5    MAGEA8    MAGEA1    MAGEA9
    MAGEA9B    MAGEC2    MAGEE1    MAGEA10    MAGEA11    MAGEB6

    Find genes that share paralogs with MAGEB4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MAGEB4
    PGOHUM00000241687


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAGEB4 (see all 24)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1902874951,2
    --30258150(+) CCACTC/TTTGGG 1 -- us2k10--------
    rs25295581,2
    C,F,A,H--30258204(+) CTATCT/AGATCT 1 -- us2k1 tfbs39Minor allele frequency- A:0.43EA NS NA WA CSA 307
    rs1825830401,2
    --30258320(+) GGACTA/GCTCAC 1 -- us2k10--------
    rs1859102151,2
    --30258337(+) ATAGAC/GAGAGC 1 -- us2k10--------
    rs1910478591,2
    --30258358(+) ACCCCC/TCTGCA 1 -- us2k10--------
    rs1811692661,2
    --30258454(+) TAGTTC/TTACGT 1 -- us2k10--------
    rs1434203901,2
    C--30258457(+) TTTTAC/TGTTCA 1 -- us2k10--------
    rs732058331,2
    --30258633(+) TGCTGC/TACATT 1 -- us2k10--------
    rs1480198271,2
    --30258664(+) AATGTA/GTAATG 1 -- us2k10--------
    rs1857720061,2
    --30258687(+) CACCAC/TAGAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAGEB4 (30260057 - 30262310 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAGEB4: --
    Locus Specific Mutation Databases (LSDB): MAGEB4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAGEB4
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGEB4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300153    OMIM disorders: --

    1 disease for MAGEB4:    
    About MalaCards
    melanoma


    Find genes that share disorders with MAGEB4           About GenesLikeMe


    Export disorders for MAGEB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAGEB4 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with MAGEB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PubMed id 9441743)1, 2, 3 Lurquin C.... Boon T. (Genomics 1997)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4115 HGNC: 6811 AceView: MAGEB1 Ensembl:ENSG00000120289 euGenes: HUgn4115
    ECgene: MAGEB4 H-InvDB: MAGEB4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAGEB4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEB4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAGEB4 gene:
    Search GeneIP for patents involving MAGEB4

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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