Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAGEB4 Gene

Aliases for MAGEB4 Gene

  • Melanoma Antigen Family B4 2 3
  • MAGE-B4 Antigen 3 4
  • Cancer/Testis Antigen Family 3, Member 6 3
  • Cancer/Testis Antigen Family 3 2
  • Melanoma-Associated Antigen B4 2
  • Melanoma Antigen Family B, 4 3
  • Member 6 2
  • CT3.6 3

External Ids for MAGEB4 Gene

Previous GeneCards Identifiers for MAGEB4 Gene

  • GC0XP028759
  • GC0XP028943
  • GC0XP029462
  • GC0XP029621
  • GC0XP030019
  • GC0XP030171
  • GC0XP027996

Summaries for MAGEB4 Gene

Entrez Gene Summary for MAGEB4 Gene

  • This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21. This gene sequence ends in the first intron of MAGEB1, another family member. This gene is expressed in testis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEB4 Gene

MAGEB4 (Melanoma Antigen Family B4) is a Protein Coding gene. An important paralog of this gene is MAGED1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB4 Gene

Genomics for MAGEB4 Gene

Regulatory Elements for MAGEB4 Gene

Genomic Location for MAGEB4 Gene

30,241,940 bp from pter
30,244,193 bp from pter
2,254 bases
Plus strand

Genomic View for MAGEB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB4 Gene

Proteins for MAGEB4 Gene

  • Protein details for MAGEB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen B4
    Protein Accession:
    Secondary Accessions:
    • B2R9G0
    • Q6FHH4
    • Q8IZ00

    Protein attributes for MAGEB4 Gene

    346 amino acids
    Molecular mass:
    38923 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEB4 Gene

Proteomics data for MAGEB4 Gene at MOPED

Post-translational modifications for MAGEB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEB4 Gene

Domains & Families for MAGEB4 Gene

Gene Families for MAGEB4 Gene

Protein Domains for MAGEB4 Gene


Suggested Antigen Peptide Sequences for MAGEB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MAGE domain.
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEB4: view

Function for MAGEB4 Gene

Molecular function for MAGEB4 Gene

GENATLAS Biochemistry:
melanoma antigen,family B,member 4,expressed in testis

Gene Ontology (GO) - Molecular Function for MAGEB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEB4: view

Phenotypes for MAGEB4 Gene

GenomeRNAi human phenotypes for MAGEB4:
genes like me logo Genes that share phenotypes with MAGEB4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEB4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEB4 Gene

Localization for MAGEB4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MAGEB4 Gene

Pathways & Interactions for MAGEB4 Gene

SuperPathways for MAGEB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB4 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAGEB4 Gene

Drugs & Compounds for MAGEB4 Gene

No Compound Related Data Available

Transcripts for MAGEB4 Gene

mRNA/cDNA for MAGEB4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB4 Gene

Melanoma antigen family B, 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEB4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for MAGEB4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEB4 Gene

mRNA expression in normal human tissues for MAGEB4 Gene

Protein differential expression in normal tissues from HIPED for MAGEB4 Gene

This gene is overexpressed in Platelet (34.2), Testis (21.0), Heart (6.9), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEB4 Gene

SOURCE GeneReport for Unigene cluster for MAGEB4 Gene Hs.113291

mRNA Expression by UniProt/SwissProt for MAGEB4 Gene

Tissue specificity: Expressed in testis
genes like me logo Genes that share expression patterns with MAGEB4: view

Protein tissue co-expression partners for MAGEB4 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAGEB4 Gene

Orthologs for MAGEB4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC101906038 35
  • 73.76 (n)
  • 58.91 (a)
-- 36
  • 52 (a)
-- 36
  • 48 (a)
-- 36
  • 54 (a)
-- 36
  • 42 (a)
-- 36
  • 49 (a)
-- 36
  • 49 (a)
-- 36
  • 50 (a)
-- 36
  • 48 (a)
-- 36
  • 52 (a)
-- 36
  • 50 (a)
-- 36
  • 42 (a)
  • 49 (a)
MGC133764 36
  • 48 (a)
(Pan troglodytes)
Mammalia MAGEB4 35
  • 99.13 (n)
  • 98.55 (a)
(Rattus norvegicus)
Mammalia Mageb1 35
  • 66.36 (n)
  • 52.48 (a)
(Mus musculus)
Mammalia Mageb2 16
Mageb4 36
  • 33 (a)
Species with no ortholog for MAGEB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB4 Gene

Gene Tree for MAGEB4 (if available)
Gene Tree for MAGEB4 (if available)

Paralogs for MAGEB4 Gene Pseudogenes for MAGEB4 Gene

genes like me logo Genes that share paralogs with MAGEB4: view

Variants for MAGEB4 Gene

Sequence variations from dbSNP and Humsavar for MAGEB4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1573631 -- 30,241,229(+) atcat(G/T)tcatg upstream-variant-2KB
rs2158945 -- 30,241,075(+) gtcca(C/T)cagca upstream-variant-2KB
rs2529558 -- 30,240,087(+) CTATC(A/T)GATCT upstream-variant-2KB
rs2529559 -- 30,240,258(+) TTAAA(G/T)TGCCA upstream-variant-2KB
rs2529560 -- 30,240,647(+) aacct(G/T)tggaa upstream-variant-2KB

Variation tolerance for MAGEB4 Gene

Residual Variation Intolerance Score: 74.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEB4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEB4 Gene

Disorders for MAGEB4 Gene

Relevant External Links for MAGEB4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAGEB4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGEB4 Gene

Publications for MAGEB4 Gene

  1. Comparative plasma proteome analysis of lymphoma-bearing SJL mice. (PMID: 16212437) Bhat V.B. … Tannenbaum S.R. (J. Proteome Res. 2005) 23 67
  2. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PMID: 9441743) Lurquin C. … Boon T. (Genomics 1997) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67

Products for MAGEB4 Gene

Sources for MAGEB4 Gene

Back to Top