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Aliases for MAGEB3 Gene

Aliases for MAGEB3 Gene

  • Melanoma Antigen Family B3 2 3
  • MAGE-B3 Antigen 3 4
  • Cancer/Testis Antigen Family 3, Member 5 3
  • Cancer/Testis Antigen Family 3 2
  • Melanoma Antigen Family B, 3 3
  • Member 5 2
  • CT3.5 3

External Ids for MAGEB3 Gene

Previous GeneCards Identifiers for MAGEB3 Gene

  • GC0XP028753
  • GC0XP028932
  • GC0XP029450
  • GC0XP029615
  • GC0XP030008
  • GC0XP030158
  • GC0XP027985

Summaries for MAGEB3 Gene

Entrez Gene Summary for MAGEB3 Gene

  • This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEB3 Gene

MAGEB3 (Melanoma Antigen Family B3) is a Protein Coding gene. Diseases associated with MAGEB3 include melanoma. An important paralog of this gene is MAGED1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB3 Gene

Genomics for MAGEB3 Gene

Regulatory Elements for MAGEB3 Gene

Genomic Location for MAGEB3 Gene

30,230,436 bp from pter
30,237,493 bp from pter
7,058 bases
Plus strand

Genomic View for MAGEB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB3 Gene

Proteins for MAGEB3 Gene

  • Protein details for MAGEB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen B3
    Protein Accession:
    Secondary Accessions:
    • A0AVE4
    • B3KQ52
    • O75861

    Protein attributes for MAGEB3 Gene

    346 amino acids
    Molecular mass:
    39211 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEB3 Gene

Proteomics data for MAGEB3 Gene at MOPED

Post-translational modifications for MAGEB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEB3 Gene

Domains & Families for MAGEB3 Gene

Gene Families for MAGEB3 Gene

Protein Domains for MAGEB3 Gene


Suggested Antigen Peptide Sequences for MAGEB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MAGE domain.
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEB3: view

Function for MAGEB3 Gene

Molecular function for MAGEB3 Gene

GENATLAS Biochemistry:
melanoma antigen,family B,member 3,expressed in normal testis and in testicular tumor

Phenotypes for MAGEB3 Gene

GenomeRNAi human phenotypes for MAGEB3:
genes like me logo Genes that share phenotypes with MAGEB3: view

Animal Model Products

miRNA for MAGEB3 Gene

miRTarBase miRNAs that target MAGEB3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEB3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEB3 Gene

Localization for MAGEB3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MAGEB3 Gene

Pathways & Interactions for MAGEB3 Gene

SuperPathways for MAGEB3 Gene

No Data Available

Interacting Proteins for MAGEB3 Gene

Gene Ontology (GO) - Biological Process for MAGEB3 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAGEB3 Gene

Drugs & Compounds for MAGEB3 Gene

No Compound Related Data Available

Transcripts for MAGEB3 Gene

mRNA/cDNA for MAGEB3 Gene

Unigene Clusters for MAGEB3 Gene

Melanoma antigen family B, 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEB3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB3 Gene

No ASD Table

Relevant External Links for MAGEB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEB3 Gene

mRNA expression in normal human tissues for MAGEB3 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEB3 Gene

This gene is overexpressed in Testis (x52.1).

Protein differential expression in normal tissues from HIPED for MAGEB3 Gene

This gene is overexpressed in Heart (48.3) and Testis (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEB3 Gene

SOURCE GeneReport for Unigene cluster for MAGEB3 Gene Hs.113290

mRNA Expression by UniProt/SwissProt for MAGEB3 Gene

Tissue specificity: Expressed in testis
genes like me logo Genes that share expression patterns with MAGEB3: view

Protein tissue co-expression partners for MAGEB3 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGEB3 Gene

Orthologs for MAGEB3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAGEB3 35
  • 74.64 (n)
  • 62.73 (a)
-- 36
  • 59 (a)
-- 36
  • 59 (a)
(Pan troglodytes)
Mammalia MAGEB3 35
  • 99.13 (n)
  • 97.4 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Mageb3 35
  • 73.54 (n)
  • 62.15 (a)
Species with no ortholog for MAGEB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB3 Gene

Gene Tree for MAGEB3 (if available)
Gene Tree for MAGEB3 (if available)

Paralogs for MAGEB3 Gene Pseudogenes for MAGEB3 Gene

genes like me logo Genes that share paralogs with MAGEB3: view

Variants for MAGEB3 Gene

Sequence variations from dbSNP and Humsavar for MAGEB3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2071308 - 30,236,244(+) GTCTC(A/G)CACAG missense, reference
rs2071309 - 30,236,259(+) TCTAA(C/T)CATGA missense, reference
rs2071310 -- 30,236,413(+) GTGGT(A/G)TTTGG reference, synonymous-codon
rs2239433 -- 30,234,767(+) AAACA(A/G)TGTCC intron-variant
rs2239434 -- 30,234,999(+) GAAGC(C/T)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEB3 Gene

Variant ID Type Subtype PubMed ID
esv2668620 CNV Deletion 23128226
esv2740048 CNV Deletion 23290073

Variation tolerance for MAGEB3 Gene

Residual Variation Intolerance Score: 82.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEB3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEB3 Gene

Disorders for MAGEB3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEB3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
- elite association

Relevant External Links for MAGEB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAGEB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEB3 Gene

Publications for MAGEB3 Gene

  1. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PMID: 9441743) Lurquin C. … Boon T. (Genomics 1997) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for MAGEB3 Gene

Sources for MAGEB3 Gene

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