MAGEB3 Gene
protein-coding GIFtS: 46
GCID: GC0XP030248
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melanoma antigen family B, 3
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Aliases
for MAGEB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family B, 31 2 | | CT3.51 2 | | MAGE-B3 Antigen2 3 | | Cancer/Testis Antigen Family 3, Member 52 | | Melanoma-Associated Antigen B32 |
Export aliases for MAGEB3 gene to outside databasesPrevious GC identifers: GC0XP028753 GC0XP028932 GC0XP029450 GC0XP029615 GC0XP030008 GC0XP030158 GC0XP027985 |
Summaries
for MAGEB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEB3:
This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression oftumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters ofMAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members ofthe MAGE-B subfamily are clustered in the Xp21 region. (provided by RefSeq, Jul 2008)
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Genomic Views
for MAGEB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEB3 gene promoter:
LHX3b/Lhx3b Brachyury RelA Ik-3 NF-kappaB c-Rel ARP-1 LHX3a/Lhx3a NF-kappaB1 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp21.3 Ensembl cytogenetic band: Xp21.2 HGNC cytogenetic band: Xp21.3MAGEB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP030248: view genomic region
(about GC identifiers)
Start:
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30,248,553 bp from pter |
End:
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30,255,610 bp from pter |
Size:
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7,058 bases |
Orientation:
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plus strand |
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Proteins
for MAGEB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGB3_HUMAN, O15480 (See
protein sequence)Recommended Name: Melanoma-associated antigen B3 Size: 346 amino acids; 39211 Da
Secondary accessions: A0AVE4 B3KQ52 O75861Explore the universe of human proteins at neXtProt for MAGEB3: NX_O15480
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15480
MAGEB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002356.2
ENSEMBL proteins: ENSP00000368271 ENSP00000355198
Human Recombinant Protein Products:
MAGEB3 Antibody Products:
Assay Products for MAGEB3: |
Protein
Domains /
Families
for MAGEB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEB3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O15480ProtoNet protein and cluster: O15480 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGB3_HUMAN, O15480Similarity: Contains 1 MAGE domain |
Function
for MAGEB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for MAGEB3:melanoma antigen,family B,member 3,expressed in normal testis and in testicular tumor
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB3 |
|
Pathways & Interactions
for MAGEB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEB3
|
Drugs & Compounds
for MAGEB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEB3
Search CenterWatch for drugs/clinical trials and news about MAGEB3 / MAGB3
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Transcripts
for MAGEB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEB3 gene: NM_002365.4 Unigene Cluster for MAGEB3: Melanoma antigen family B, 3 Hs.113290 [show with all ESTs]Unigene Representative Sequence: NM_0023652 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378986 ENST00000361644(uc004dca.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAGEB3 (NM_002365) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEB3 |
Additional cDNA sequence: AK057441.1 BC069784.1 BC074756.2 BC126320.1 BC126322.1 1 DOTS entry: DT.106558 24/61 AceView cDNA sequences (see all 61): CR618499 CR593708 CR618278 CR621494 BX107939 NM_002365 BI520298 CR590008 CR611588 BC069784 BU629619 AA815379 AI637744 BP430619 BI831893 NM_002364 AF015766 AL562631 AK057441 CA423793 AA936574 BC026071 CA428956 BM453282
GeneLoc Exon Structure
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Expression
for MAGEB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCAGAAAGT
About this image
See MAGEB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEB3
SOURCE GeneReport for Unigene cluster: Hs.113290
UniProtKB/Swiss-Prot: MAGB3_HUMAN, O15480Tissue specificity: Expressed in testis
SABiosciences Custom PCR Arrays for MAGEB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEB3
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB3 |
Orthologs
for MAGEB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for MAGEB3 gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
37(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
31(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
23(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEB3 (if available)
TreeFam Gene Tree for MAGEB3 (if available) |
Paralogs
for MAGEB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEB3 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGEA82 MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12
- MAGED12 MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGED4B2 MAGEE22
- MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/39 SIMAP similar genes for MAGEB3 using alignment to 1 protein entry: MAGB3_HUMAN(see all similar genes):MAGE-B1 MAGEB1 MAGEB17 MAGEB2 MAGEB4 MAGEC4
MAGEB10 MAGEB5 MAGEH1 MAGEB18 MAGEC3 MAGEB16
MAGEB6 MAGEC2 MAGEC1 MAGEA11 MAGEA8 MAGEF1
MAGEB3 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for MAGEB3
PGOHUM00000241671 PGOHUM00000241673 PGOHUM00000241675
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Genomic Variants
for MAGEB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEB3 (30248553 - 30255610 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAGEB3
1 CNV: 3265
Locus Specific Mutation Databases (LSDB): MAGEB3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEB3 |
|
Disorders
/ Diseases
for MAGEB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEB3 for disorders About GeneDecksing
OMIM gene information: 300152
OMIM disorders: --
3  diseases for MAGEB3: About MalaCardsmelanoma hepatocellular carcinoma carcinoma
Export disorders for MAGEB3 gene to outside databases
|
Publications
for MAGEB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEB3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAGEB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PubMed id 9441743)1, 2, 3 Lurquin C.... Boon T. (1997)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PubMed id 10861452)1 Lucas S.... Boon T. (2000)
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External Searches for MAGEB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MAGEB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEB3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEB3 gene:
Search GeneIP for patents involving MAGEB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | MAGEB3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB3 |
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