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Aliases for MAGEB2 Gene

Aliases for MAGEB2 Gene

  • Melanoma Antigen Family B2 2 3
  • DSS/AHC Critical Interval MAGE Superfamily 6 2 3
  • DSS-AHC Critical Interval MAGE Superfamily 6 3 4
  • Cancer/Testis Antigen 3.2 3 4
  • MAGE XP-2 Antigen 3 4
  • MAGE-B2 Antigen 3 4
  • CT3.2 3 4
  • DAM6 3 4
  • Cancer/Testis Antigen Family 3, Member 2 3
  • Cancer/Testis Antigen Family 3 2
  • Melanoma-Associated Antigen B2 2
  • Melanoma Antigen Family B, 2 3
  • MAGE-XP-2 3
  • Member 2 2

External Ids for MAGEB2 Gene

Previous GeneCards Identifiers for MAGEB2 Gene

  • GC0XP028733
  • GC0XP028917
  • GC0XP029435
  • GC0XP029595
  • GC0XP029993
  • GC0XP030143
  • GC0XP027970

Summaries for MAGEB2 Gene

Entrez Gene Summary for MAGEB2 Gene

  • This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEB2 Gene

MAGEB2 (Melanoma Antigen Family B2) is a Protein Coding gene. Diseases associated with MAGEB2 include melanoma. An important paralog of this gene is MAGED1.

UniProtKB/Swiss-Prot for MAGEB2 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Wiki entry for MAGEB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB2 Gene

Genomics for MAGEB2 Gene

Regulatory Elements for MAGEB2 Gene

Genomic Location for MAGEB2 Gene

Chromosome:
X
Start:
30,215,558 bp from pter
End:
30,220,089 bp from pter
Size:
4,532 bases
Orientation:
Plus strand

Genomic View for MAGEB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB2 Gene

Proteins for MAGEB2 Gene

  • Protein details for MAGEB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15479-MAGB2_HUMAN
    Recommended name:
    Melanoma-associated antigen B2
    Protein Accession:
    O15479
    Secondary Accessions:
    • O75860

    Protein attributes for MAGEB2 Gene

    Size:
    319 amino acids
    Molecular mass:
    35277 Da
    Quaternary structure:
    • Interacts with TRIM28.

neXtProt entry for MAGEB2 Gene

Proteomics data for MAGEB2 Gene at MOPED

Post-translational modifications for MAGEB2 Gene

  • Ubiquitination at Lys 114
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MAGEB2 Gene

Domains & Families for MAGEB2 Gene

Gene Families for MAGEB2 Gene

Protein Domains for MAGEB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15479

UniProtKB/Swiss-Prot:

MAGB2_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEB2: view

Function for MAGEB2 Gene

Molecular function for MAGEB2 Gene

GENATLAS Biochemistry:
melanoma antigen,family B,member 2,expressed in placenta,testis,melanoma and lung carcinomas
UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Ontology (GO) - Molecular Function for MAGEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEB2: view
genes like me logo Genes that share phenotypes with MAGEB2: view

Animal Model Products

miRNA for MAGEB2 Gene

miRTarBase miRNAs that target MAGEB2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEB2 Gene

Localization for MAGEB2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MAGEB2 Gene

Pathways & Interactions for MAGEB2 Gene

SuperPathways for MAGEB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEB2 Gene

Drugs & Compounds for MAGEB2 Gene

No Compound Related Data Available

Transcripts for MAGEB2 Gene

mRNA/cDNA for MAGEB2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(61) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB2 Gene

Melanoma antigen family B, 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB2 Gene

ExUns: 1 ^ 2a · 2b · 2c
SP1: -
SP2:

Relevant External Links for MAGEB2 Gene

GeneLoc Exon Structure for
MAGEB2
ECgene alternative splicing isoforms for
MAGEB2

Expression for MAGEB2 Gene

mRNA expression in normal human tissues for MAGEB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEB2 Gene

This gene is overexpressed in Testis (x50.5).

Protein differential expression in normal tissues from HIPED for MAGEB2 Gene

This gene is overexpressed in Testis (31.6), Urine (20.0), and Ovary (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEB2 Gene



SOURCE GeneReport for Unigene cluster for MAGEB2 Gene Hs.113824

mRNA Expression by UniProt/SwissProt for MAGEB2 Gene

O15479-MAGB2_HUMAN
Tissue specificity: Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types
genes like me logo Genes that share expression patterns with MAGEB2: view

Protein tissue co-expression partners for MAGEB2 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for MAGEB2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC788399 35
  • 69.26 (n)
  • 54.73 (a)
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
MAGEB4 36
  • 44 (a)
ManyToMany
MGC133764 36
  • 42 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia MAGEB4 35
  • 75.69 (n)
  • 64.33 (a)
mouse
(Mus musculus)
Mammalia Mageb4 35
  • 70.28 (n)
  • 54.46 (a)
Mageb4 16
Mageb4 36
  • 31 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MAGEB2 35
  • 98.54 (n)
  • 96.24 (a)
MAGEB2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mageb2 35
  • 70.31 (n)
  • 56.27 (a)
Species with no ortholog for MAGEB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB2 Gene

ENSEMBL:
Gene Tree for MAGEB2 (if available)
TreeFam:
Gene Tree for MAGEB2 (if available)

Paralogs for MAGEB2 Gene

genes like me logo Genes that share paralogs with MAGEB2: view

Variants for MAGEB2 Gene

Sequence variations from dbSNP and Humsavar for MAGEB2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs714793 -- 30,217,416(-) CTTAA(C/T)GATGA intron-variant
rs1053918 -- 30,219,973(+) AGAGG(G/T)GTAAA utr-variant-3-prime
rs1894386 -- 30,218,277(+) AGGCC(G/T)CACTG intron-variant
rs1974548 -- 30,220,471(+) accct(A/G)tctct downstream-variant-500B
rs2074793 -- 30,218,886(+) ACATC(C/T)ACTAA reference, synonymous-codon

Variation tolerance for MAGEB2 Gene

Residual Variation Intolerance Score: 81.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 21.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEB2 Gene

HapMap Linkage Disequilibrium report
MAGEB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEB2 Gene

Disorders for MAGEB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEB2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association

Relevant External Links for MAGEB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEB2
genes like me logo Genes that share disorders with MAGEB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEB2 Gene

Publications for MAGEB2 Gene

  1. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PMID: 9441743) Lurquin C. … Boon T. (Genomics 1997) 2 23 67
  2. Expression of cancer/testis (CT) antigens in Chinese hepatocellular carcinoma and its correlation with clinical parameters. (PMID: 15723723) Peng J.R. … Chen W.F. (Cancer Lett. 2005) 23 67
  3. [Expression of MAGE-B genes in hepatocellular carcinoma]. (PMID: 15059354) Mou D.C. … Zhu J.Y. (Zhonghua Zhong Liu Za Zhi 2004) 23 67
  4. Prognostic significance of cancer-testis gene expression in resected non-small cell lung cancer patients. (PMID: 15201976) Melloni G. … Traversari C. (Oncol. Rep. 2004) 23 67
  5. MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera. (PMID: 9538511) McCurdy D.K. … Gatti R.A. (Mol. Genet. Metab. 1998) 23 67

Products for MAGEB2 Gene

Sources for MAGEB2 Gene

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