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MAGEB2 Gene

protein-coding   GIFtS: 55
GCID: GC0XP030233

Melanoma Antigen Family B, 2

  See MAGEB2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Melanoma Antigen Family B, 21 2     MAGE XP-2 Antigen2 3
DAM62 3 5     MAGE-B2 Antigen2 3
DSS/AHC Critical Interval MAGE Superfamily 61 2     Cancer/Testis Antigen Family 31
Melanoma-Associated Antigen B21 2     Member 21
Cancer/Testis Antigen 3.22 3     MAGE-XP-22
CT3.22 3     Cancer/Testis Antigen Family 3, Member 22
DSS-AHC Critical Interval MAGE Superfamily 62 3     

External Ids:    HGNC: 68091   Entrez Gene: 41132   Ensembl: ENSG000000993997   OMIM: 3000985   UniProtKB: O154793   

Export aliases for MAGEB2 gene to outside databases

Previous GC identifers: GC0XP028733 GC0XP028917 GC0XP029435 GC0XP029595 GC0XP029993 GC0XP030143 GC0XP027970


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAGEB2 Gene:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences
located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters
and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene
family enables the same function to be expressed under different transcriptional controls. This gene is localized
in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a
significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome
Xp22-p21. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAGEB2 Gene:
MAGEB2 (melanoma antigen family B, 2) is a protein-coding gene. Diseases associated with MAGEB2 include dosage-sensitive sex reversal, and melanoma. An important paralog of this gene is MAGEC2.

UniProtKB/Swiss-Prot: MAGB2_HUMAN, O15479
Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.
Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate
complex

Gene Wiki entry for MAGEB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAGEB2 gene promoter:
         Pbx1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   MEF-2A   c-Rel   POU2F1   FOXO4   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGEB2 promoter sequence
   Search Chromatin IP Primers for MAGEB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGEB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.3   Ensembl cytogenetic band:  Xp21.2   HGNC cytogenetic band: Xp21.3

MAGEB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEB2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP030233:  view genomic region     (about GC identifiers)

Start:
30,233,675 bp from pter      End:
30,238,206 bp from pter
Size:
4,532 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAGB2_HUMAN, O15479 (See protein sequence)
Recommended Name: Melanoma-associated antigen B2  
Size: 319 amino acids; 35277 Da
Subunit: Interacts with TRIM28
Secondary accessions: O75860

Explore the universe of human proteins at neXtProt for MAGEB2: NX_O15479

Explore proteomics data for MAGEB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys114, Lys287
  • Modification sites at PhosphoSitePlus

  • See MAGEB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002355.2  
    ENSEMBL proteins: 
     ENSP00000368273  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry O15479

    ProtoNet protein and cluster: O15479

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGB2_HUMAN, O15479
    Similarity: Contains 1 MAGE domain


    Find genes that share domains with MAGEB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAGB2_HUMAN, O15479
    Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.
    Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate
    complex

         Genatlas biochemistry entry for MAGEB2:
    melanoma antigen,family B,member 2,expressed in placenta,testis,melanoma and lung carcinomas

    Phenotypes:
         2 GenomeRNAi human phenotypes for MAGEB2:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAGEB2
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    miRTarBase miRNAs that target MAGEB2:
    hsa-mir-193b-3p (MIRT041337), hsa-mir-98-5p (MIRT027712)

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    6 qRT-PCR Assays for microRNAs that regulate MAGEB2:
    hsa-miR-23b hsa-miR-130a* hsa-miR-3613-3p hsa-miR-23a hsa-miR-3120-3p hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidMAGEB2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAGEB2
    Interactions:

        Search GeneGlobe Interaction Network for MAGEB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAGEB2 (O154793 ENSP000003682734) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224774P678703, ENSP000004156154I2D: score=2 STRING: ENSP00000415615
    ENSG00000232960P678703, ENSP000003955464I2D: score=2 STRING: ENSP00000395546
    CSNK2BP678703I2D: score=2 
    ENSG00000206406P678703I2D: score=2 
    ENSG00000224398P678703I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAGEB2 (MAGB2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAGEB2 gene: 
    NM_002364.4  

    Unigene Cluster for MAGEB2:

    Melanoma antigen family B, 2
    Hs.113824  [show with all ESTs]
    Unigene Representative Sequence: NM_002364
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000378988(uc004dbz.3)
    miRNA
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    hsa-miR-23b hsa-miR-130a* hsa-miR-3613-3p hsa-miR-23a hsa-miR-3120-3p hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidMAGEB2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat MAGEB2

    Additional mRNA sequence: 

    AF015766.1 AK223081.1 AK313347.1 BC026071.2 

    2 DOTS entries:

    DT.307058  DT.95163778 

    Selected AceView cDNA sequences (see all 61):

    NM_002365 BI520298 CR590008 CR593708 CR618499 BX107939 CR611588 CR621494 
    CR618278 BU621468 BX113848 BU175305 AW589912 AA889133 BM473754 BQ773446 
    NM_002364 BC026071 BU188463 AA936574 BM471242 BP430619 AL525917 AF015766 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c
    SP1:        -               
    SP2:                        


    ECgene alternative splicing isoforms for MAGEB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAGEB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAACTTGT
    MAGEB2 Expression
    About this image


    MAGEB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
    MAGEB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAGEB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.113824

    UniProtKB/Swiss-Prot: MAGB2_HUMAN, O15479
    Tissue specificity: Expressed in testis and placenta, and in a significant fraction of tumors of various
    histologic types

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MAGEB2 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mageb41 , 5 melanoma antigen, family B, 41, 5 70.28(n)1
    54.46(a)1
      X (39.71 cM)5
    4349031  NM_001033492.21  NP_001028664.21 
     862502545 


    ENSEMBL Gene Tree for MAGEB2 (if available)
    TreeFam Gene Tree for MAGEB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAGEB2 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEB42  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGED12  
    MAGEA22  MAGEA32  NDN2  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  MAGEA102  
    MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  MAGEA112  NDNL22  MAGEF12  
    Selected SIMAP similar genes for MAGEB2 using alignment to 1 protein entry:     MAGB2_HUMAN(see all similar genes):
    MAGE-B1    MAGEB1    MAGEB4    MAGEB17    MAGEB5    MAGEB18
    MAGEB3    MAGEH1    MAGEC1    MAGEC4    MAGEB10    MAGEB16
    MAGEA8    MAGEA11    MAGEB6    MAGEC2    MAGED4    MAGED4B

    Find genes that share paralogs with MAGEB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAGEB2 (see all 182)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894021411,2
    --30146401(+) AAAAAA/CTGGTC 1 -- us2k10--------
    rs1926015391,2
    --30146403(+) AAACTG/TGTCAT 1 -- us2k10--------
    rs734603671,2
    C,F--30146526(+) CTCATG/CTGCTC 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1478432921,2
    C--30146601(+) TCTCAC/TGGACA 1 -- us2k10--------
    rs1394713081,2
    C--30146637(+) CAGTAC/GATGCA 1 -- us2k10--------
    rs1837698531,2
    --30146788(+) CACCAC/TAACTT 1 -- us2k10--------
    rs22389201,2
    C,F,O,A,H--30146848(+) CCTCAA/GGTCAG 1 -- us2k1 tfbs319Minor allele frequency- G:0.84NS EA NA CSA 2116
    rs117975941,2
    C,F,A,H--30146864(+) GATGGA/CGTGCC 1 -- us2k117Minor allele frequency- C:0.09NS EA NA 1857
    rs22389221,2
    C,F,H--30147145(+) ggtaaA/Ggggga 1 -- us2k18Minor allele frequency- G:0.19NS EA NA WA 401
    rs1504662661,2
    --30147157(+) GAAATA/CATCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAGEB2 (30233675 - 30238206 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAGEB2: --
    Locus Specific Mutation Databases (LSDB): MAGEB2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAGEB2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGEB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300098    OMIM disorders: --

    2 diseases for MAGEB2:    
    About MalaCards
    dosage-sensitive sex reversal    melanoma


    Find genes that share disorders with MAGEB2           About GenesLikeMe

    1 Novoseek inferred disease relationship for MAGEB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 18.3 2 9441743 (2)


    Export disorders for MAGEB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAGEB2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with MAGEB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PubMed id 9441743)1, 2, 3, 9 Lurquin C.... Boon T. (Genomics 1997)
    2. MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera. (PubMed id 9538511)1, 2, 9 McCurdy D.K.... Gatti R.A. (Mol. Genet. Metab. 1998)
    3. A family of rapidly evolving genes from the sex reversal critical region in Xp21. (PubMed id 8535061)1, 2, 9 Dabovic B.... Camerino G. (Mamm. Genome 1995)
    4. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PubMed id 20864041)1, 2 Doyle J.M.... Potts P.R. (Mol. Cell 2010)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. MAGEB2 is activated by promoter demethylation in head and neck squamous cell carcinoma. (PubMed id 23029077)1 Pattani K.M....Califano J.A. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4113 HGNC: 6809 AceView: MAGEB2andMAGEB3 Ensembl:ENSG00000099399 euGenes: HUgn4113
    ECgene: MAGEB2 H-InvDB: MAGEB2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAGEB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEB2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAGEB2 gene:
    Search GeneIP for patents involving MAGEB2

    GeneCards and IP:
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