Aliases for MAGEB2 Gene
External Ids for MAGEB2 Gene
Previous GeneCards Identifiers for MAGEB2 Gene
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAGEB2 Gene
MAGEB2 (MAGE Family Member B2) is a Protein Coding gene. An important paralog of this gene is MAGEB4.
UniProtKB/Swiss-Prot for MAGEB2 Gene
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.