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Aliases for MAGEB2 Gene

Aliases for MAGEB2 Gene

  • Melanoma Antigen Family B2 2 3
  • DAM6 3 4 6
  • DSS/AHC Critical Interval MAGE Superfamily 6 2 3
  • DSS-AHC Critical Interval MAGE Superfamily 6 3 4
  • Melanoma-Associated Antigen B2 2 3
  • Cancer/Testis Antigen 3.2 3 4
  • MAGE XP-2 Antigen 3 4
  • MAGE-B2 Antigen 3 4
  • CT3.2 3 4
  • Cancer/Testis Antigen Family 3, Member 2 3
  • Cancer/Testis Antigen Family 3 2
  • Melanoma Antigen Family B, 2 3
  • MAGE-XP-2 3
  • Member 2 2

External Ids for MAGEB2 Gene

Previous GeneCards Identifiers for MAGEB2 Gene

  • GC0XP028733
  • GC0XP028917
  • GC0XP029435
  • GC0XP029595
  • GC0XP029993
  • GC0XP030143
  • GC0XP027970

Summaries for MAGEB2 Gene

Entrez Gene Summary for MAGEB2 Gene

  • This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEB2 Gene

MAGEB2 (Melanoma Antigen Family B2) is a Protein Coding gene. Diseases associated with MAGEB2 include melanoma. An important paralog of this gene is MAGED1.

UniProtKB/Swiss-Prot for MAGEB2 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Wiki entry for MAGEB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB2 Gene

Genomics for MAGEB2 Gene

Regulatory Elements for MAGEB2 Gene

Genomic Location for MAGEB2 Gene

Start:
30,215,558 bp from pter
End:
30,220,089 bp from pter
Size:
4,532 bases
Orientation:
Plus strand

Genomic View for MAGEB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB2 Gene

Proteins for MAGEB2 Gene

  • Protein details for MAGEB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15479-MAGB2_HUMAN
    Recommended name:
    Melanoma-associated antigen B2
    Protein Accession:
    O15479
    Secondary Accessions:
    • O75860

    Protein attributes for MAGEB2 Gene

    Size:
    319 amino acids
    Molecular mass:
    35277 Da
    Quaternary structure:
    • Interacts with TRIM28.

neXtProt entry for MAGEB2 Gene

Proteomics data for MAGEB2 Gene at MOPED

Post-translational modifications for MAGEB2 Gene

  • Ubiquitination at Lys114 and Lys287
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEB2 Gene

Domains for MAGEB2 Gene

Protein Domains for MAGEB2 Gene

Suggested Antigen Peptide Sequences for MAGEB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15479

UniProtKB/Swiss-Prot:

MAGB2_HUMAN :
  • O15479
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEB2: view

No data available for Gene Families for MAGEB2 Gene

Function for MAGEB2 Gene

Molecular function for MAGEB2 Gene

GENATLAS Biochemistry: melanoma antigen,family B,member 2,expressed in placenta,testis,melanoma and lung carcinomas
UniProtKB/Swiss-Prot Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Ontology (GO) - Molecular Function for MAGEB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEB2: view

Phenotypes for MAGEB2 Gene

GenomeRNAi human phenotypes for MAGEB2:
genes like me logo Genes that share phenotypes with MAGEB2: view

miRNA for MAGEB2 Gene

miRTarBase miRNAs that target MAGEB2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAGEB2 Gene

Localization for MAGEB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEB2 Gene COMPARTMENTS Subcellular localization image for MAGEB2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEB2 Gene

Pathways for MAGEB2 Gene

SuperPathways for MAGEB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB2 Gene

None

No data available for Pathways by source for MAGEB2 Gene

Transcripts for MAGEB2 Gene

mRNA/cDNA for MAGEB2 Gene

(61) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB2 Gene

Melanoma antigen family B, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB2 Gene

ExUns: 1 ^ 2a · 2b · 2c
SP1: -
SP2:

Relevant External Links for MAGEB2 Gene

GeneLoc Exon Structure for
MAGEB2
ECgene alternative splicing isoforms for
MAGEB2

Expression for MAGEB2 Gene

mRNA expression in normal human tissues for MAGEB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEB2 Gene

This gene is overexpressed in Testis (50.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEB2 Gene

SOURCE GeneReport for Unigene cluster for MAGEB2 Gene Hs.113824

mRNA Expression by UniProt/SwissProt for MAGEB2 Gene

O15479-MAGB2_HUMAN
Tissue specificity: Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types
genes like me logo Genes that share expressions with MAGEB2: view

Orthologs for MAGEB2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEB2 35
  • 98.54 (n)
  • 96.24 (a)
MAGEB2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
LOC788399 35
  • 69.26 (n)
  • 54.73 (a)
MAGEB4 36
  • 44 (a)
ManyToMany
MGC133764 36
  • 42 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia MAGEB4 35
  • 75.69 (n)
  • 64.33 (a)
mouse
(Mus musculus)
Mammalia Mageb4 35
  • 70.28 (n)
  • 54.46 (a)
Mageb4 16
Mageb4 36
  • 31 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mageb2 35
  • 70.31 (n)
  • 56.27 (a)
Species with no ortholog for MAGEB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB2 Gene

ENSEMBL:
Gene Tree for MAGEB2 (if available)
TreeFam:
Gene Tree for MAGEB2 (if available)

Paralogs for MAGEB2 Gene

genes like me logo Genes that share paralogs with MAGEB2: view

Variants for MAGEB2 Gene

Sequence variations from dbSNP and Humsavar for MAGEB2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs714793 -- 30,217,416(-) CTTAA(C/T)GATGA intron-variant
rs1053918 -- 30,219,973(+) AGAGG(G/T)GTAAA utr-variant-3-prime
rs1894386 -- 30,218,277(+) AGGCC(G/T)CACTG intron-variant
rs1974548 -- 30,220,471(+) accct(A/G)tctct downstream-variant-500B
rs2074793 -- 30,218,886(+) ACATC(C/T)ACTAA reference, synonymous-codon

Relevant External Links for MAGEB2 Gene

HapMap Linkage Disequilibrium report
MAGEB2
Locus Specific Mutation Databases (LSDB)
MAGEB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEB2 Gene

Disorders for MAGEB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MAGEB2 Gene including...

Search for MAGEB2 Gene in MalaCards »

(1) Novoseek inferred disease relationships for MAGEB2 Gene

Disease -log(P) Hits PubMed IDs
tumors 18.3 2
genes like me logo Genes that share disorders with MAGEB2: view

No data available for UniProtKB/Swiss-Prot for MAGEB2 Gene

Publications for MAGEB2 Gene

  1. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PMID: 9441743) Lurquin C. … Boon T. (Genomics 1997) 2 3 4 23
  2. MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera. (PMID: 9538511) McCurdy D.K. … Gatti R.A. (Mol. Genet. Metab. 1998) 3 4 23
  3. A family of rapidly evolving genes from the sex reversal critical region in Xp21. (PMID: 8535061) Dabovic B. … Camerino G. (Mamm. Genome 1995) 3 4 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for MAGEB2 Gene

Sources for MAGEB2 Gene

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