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Aliases for MAGEB18 Gene

Aliases for MAGEB18 Gene

  • MAGE Family Member B18 2 3 5
  • Melanoma Antigen Family B18 2
  • MAGE-B18 Antigen 4

External Ids for MAGEB18 Gene

Previous GeneCards Identifiers for MAGEB18 Gene

  • GC0XP025917
  • GC0XP026066
  • GC0XP023893

Summaries for MAGEB18 Gene

GeneCards Summary for MAGEB18 Gene

MAGEB18 (MAGE Family Member B18) is a Protein Coding gene. An important paralog of this gene is MAGEC3.

UniProtKB/Swiss-Prot for MAGEB18 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB18 Gene

Genomics for MAGEB18 Gene

Regulatory Elements for MAGEB18 Gene

Genomic Location for MAGEB18 Gene

26,138,343 bp from pter
26,140,736 bp from pter
2,394 bases
Plus strand

Genomic View for MAGEB18 Gene

Genes around MAGEB18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEB18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEB18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB18 Gene

Proteins for MAGEB18 Gene

  • Protein details for MAGEB18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen B18
    Protein Accession:

    Protein attributes for MAGEB18 Gene

    343 amino acids
    Molecular mass:
    38533 Da
    Quaternary structure:
    • Interacts with LNX1.

neXtProt entry for MAGEB18 Gene

Proteomics data for MAGEB18 Gene at MOPED

Post-translational modifications for MAGEB18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MAGEB18 Gene

Domains & Families for MAGEB18 Gene

Gene Families for MAGEB18 Gene

Protein Domains for MAGEB18 Gene


Suggested Antigen Peptide Sequences for MAGEB18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MAGE domain.
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEB18: view

Function for MAGEB18 Gene

Molecular function for MAGEB18 Gene

UniProtKB/Swiss-Prot Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
genes like me logo Genes that share phenotypes with MAGEB18: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEB18 Gene

Localization for MAGEB18 Gene

Subcellular locations from

Jensen Localization Image for MAGEB18 Gene COMPARTMENTS Subcellular localization image for MAGEB18 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEB18 Gene

Pathways & Interactions for MAGEB18 Gene

SuperPathways for MAGEB18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB18 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAGEB18 Gene

Drugs & Compounds for MAGEB18 Gene

No Compound Related Data Available

Transcripts for MAGEB18 Gene

mRNA/cDNA for MAGEB18 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB18 Gene

Melanoma antigen family B, 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB18 Gene

No ASD Table

Relevant External Links for MAGEB18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEB18 Gene

mRNA expression in normal human tissues for MAGEB18 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEB18 Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for MAGEB18 Gene

This gene is overexpressed in Placenta (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEB18 Gene

SOURCE GeneReport for Unigene cluster for MAGEB18 Gene Hs.350683

genes like me logo Genes that share expression patterns with MAGEB18: view

Protein tissue co-expression partners for MAGEB18 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAGEB18 Gene

Orthologs for MAGEB18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAGEB18 35
  • 77.38 (n)
  • 66.56 (a)
MAGEB18 36
  • 66 (a)
(Canis familiaris)
Mammalia MAGEB18 35
  • 78.95 (n)
  • 70.83 (a)
MAGEB18 36
  • 66 (a)
(Mus musculus)
Mammalia Mageb18 35
  • 71.54 (n)
  • 60.54 (a)
Mageb18 16
Mageb18 36
  • 59 (a)
(Pan troglodytes)
Mammalia MAGEB18 35
  • 99.42 (n)
  • 99.13 (a)
MAGEB18 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mageb18 35
  • 71.66 (n)
  • 60.88 (a)
Species with no ortholog for MAGEB18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB18 Gene

Gene Tree for MAGEB18 (if available)
Gene Tree for MAGEB18 (if available)

Paralogs for MAGEB18 Gene Pseudogenes for MAGEB18 Gene

genes like me logo Genes that share paralogs with MAGEB18: view

Variants for MAGEB18 Gene

Sequence variations from dbSNP and Humsavar for MAGEB18 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5944317 - 26,139,103(+) CCTCC(C/T)CTGCC reference, missense
rs4898259 -- 26,140,692(+) CTTAG(C/T)TTACT utr-variant-3-prime
rs5943844 -- 26,138,941(+) ATCAA(C/T)TCAAC utr-variant-5-prime
rs5943845 -- 26,138,942(+) TCAAT(C/T)CAACT utr-variant-5-prime
rs6526549 -- 26,138,331(+) CGTTA(A/T)GCTGG upstream-variant-2KB

Variation tolerance for MAGEB18 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEB18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEB18 Gene

Disorders for MAGEB18 Gene

Relevant External Links for MAGEB18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAGEB18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGEB18 Gene

Publications for MAGEB18 Gene

  1. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle J.M. … Potts P.R. (Mol. Cell 2010) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3
  4. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns S.L. … Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010) 3
  5. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3

Products for MAGEB18 Gene

Sources for MAGEB18 Gene

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