MAGEB18 Gene
protein-coding GIFtS: 47
GCID: GC0XP026156
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|
melanoma antigen family B, 18
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Aliases
for MAGEB18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family B, 181 2 | | MAGE-B18 Antigen2 3 | | MGC338891 | | Melanoma-Associated Antigen B182 |
Export aliases for MAGEB18 gene to outside databasesPrevious GC identifers: GC0XP025917 GC0XP026066 GC0XP023893 |
Summaries
for MAGEB18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MAGBI_HUMAN, Q96M61Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substratecomplex
|
Genomic Views
for MAGEB18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEB18 gene promoter:
Nkx3-1 Nkx3-1 v4 Pax-5 HSF1 (long) Pax-2 Nkx3-1 v1 Pax-2a Evi-1 Nkx3-1 v2 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEB18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEB18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp21.3 Ensembl cytogenetic band: Xp21.3 HGNC cytogenetic band: Xp21.3MAGEB18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP026156: view genomic region
(about GC identifiers)
Start:
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26,156,460 bp from pter |
End:
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26,158,853 bp from pter |
Size:
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2,394 bases |
Orientation:
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plus strand |
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Proteins
for MAGEB18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGBI_HUMAN, Q96M61 (See
protein sequence)Recommended Name: Melanoma-associated antigen B18 Size: 343 amino acids; 38533 Da
Subunit: Interacts with LNX1Explore the universe of human proteins at neXtProt for MAGEB18: NX_Q96M61
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96M61
MAGEB18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775970.1
ENSEMBL proteins: ENSP00000314543
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
MAGEB18 for ontologies About GeneDecksing
MAGEB18 Antibody Products:
Assay Products for MAGEB18: |
Protein
Domains /
Families
for MAGEB18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEB18 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96M61ProtoNet protein and cluster: Q96M61 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGBI_HUMAN, Q96M61Similarity: Contains 1 MAGE domain |
Function
for MAGEB18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAGBI_HUMAN, Q96M61Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substratecomplex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MAGEB18 (NM_173699) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEB18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEB18 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB18 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
MAGEB18 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MAGEB18:
|
Pathways & Interactions
for MAGEB18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEB18
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for MAGEB18 (Q96M611, 2, 3 ENSP000003145434) via UniProtKB, MINT, STRING, and/or I2D (see all 8)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TNIP1 | Q150251, 2, 3, ENSP000003178914 | EBI-741835,EBI-357849 MINT-67152 I2D:
score=5 STRING: ENSP00000317891 | | LNX1 | Q8TBB11, 2, 3, ENSP000002639254 | EBI-741835,EBI-739832 MINT-67378 I2D:
score=4 STRING: ENSP00000263925 | | TP53 | P046372, 3, ENSP000002693054 | MINT-66234 MINT-2879329 I2D:
score=4 STRING: ENSP00000269305 | | TRIM37 | O949722, 3, ENSP000002622944 | MINT-66203 I2D:
score=4 STRING: ENSP00000262294 | | GABPB1 | Q065471, 3, ENSP000003702594 | EBI-741835,EBI-618165 I2D:
score=3 STRING: ENSP00000370259 |
About this table
|
Drugs & Compounds
for MAGEB18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEB18
Search CenterWatch for drugs/clinical trials and news about MAGEB18 / MAGBI
|
Transcripts
for MAGEB18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEB18 gene: NM_173699.3 Unigene Cluster for MAGEB18: Melanoma antigen family B, 18 Hs.350683 [show with all ESTs]Unigene Representative Sequence: BC0295251 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000325250(uc004dbq.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAGEB18 (NM_173699) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEB18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEB18 |
Additional cDNA sequence: AK057361.1 BC029525.1 1 DOTS entry: DT.100009708 4 AceView cDNA sequences: AK057361 NM_173699 BC029525 BI561895
GeneLoc Exon Structure
|
Expression
for MAGEB18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEB18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAAGTGAAA
About this image
See MAGEB18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEB18
SOURCE GeneReport for Unigene cluster: Hs.350683
SABiosciences Custom PCR Arrays for MAGEB18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEB18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAGEB18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEB18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEB18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB18 |
Orthologs
for MAGEB18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEB18 gene from 3/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
37(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
30(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
22(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEB18 (if available)
TreeFam Gene Tree for MAGEB18 (if available) |
Paralogs
for MAGEB18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEB18 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGEA82 MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12
- MAGED12 MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2
- MAGEE22 MAGEA42 MAGEA12 MAGEA102 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/34 SIMAP similar genes for MAGEB18 using alignment to 1 protein entry: MAGBI_HUMAN(see all similar genes):MAGE-B1 MAGEB1 MAGEB16 MAGEB2 MAGEB4 MAGEC4
MAGEB10 MAGEB17 MAGEA11 MAGEC1 MAGEH1 MAGEA8
MAGEB3 MAGEA13P MAGEA1 MAGEA9 MAGEA9B MAGEB5
MAGEB18 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for MAGEB18
PGOHUM00000241685 PGOHUM00000241686 PGOHUM00000241697
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Genomic Variants
for MAGEB18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEB18 (26156460 - 26158853 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAGEB18: --
Locus Specific Mutation Databases (LSDB): MAGEB18
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEB18 |
|
Disorders
/ Diseases
for MAGEB18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEB18 for disorders About GeneDecksing
4  diseases for MAGEB18: About MalaCardsmelanoma prostate cancer ataxia prostatitis
Export disorders for MAGEB18 gene to outside databases
|
Publications
for MAGEB18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEB18 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAGEB18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MAGE-RING protein complexes comprise a family of E3 u biquitin ligases. (PubMed id 20864041)1, 2 Doyle J.M....Potts P.R. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1 Kerns S.L....Rosenstein B.S. (2010)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MAGEB18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEB18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEB18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEB18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEB18 gene:
Search GeneIP for patents involving MAGEB18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEB18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for MAGEB18 | | OriGene Custom Protein Services for MAGEB18 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAGEB18 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEB18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEB18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAGEB18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEB18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEB18 |
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| |  |  |  |  | | | | |
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 | | | MAGEB18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB18 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEB18 |
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