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Aliases for MAGEB18 Gene

Aliases for MAGEB18 Gene

  • Melanoma Antigen Family B18 2 3
  • MAGE-B18 Antigen 4

External Ids for MAGEB18 Gene

Summaries for MAGEB18 Gene

GeneCards Summary for MAGEB18 Gene

MAGEB18 (Melanoma Antigen Family B18) is a Protein Coding gene. An important paralog of this gene is MAGED1.

UniProtKB/Swiss-Prot for MAGEB18 Gene

  • May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB18 Gene

Genomics for MAGEB18 Gene

Genomic Location for MAGEB18 Gene

Start:
26,138,343 bp from pter
End:
26,140,736 bp from pter
Size:
2,394 bases
Orientation:
Plus strand

Genomic View for MAGEB18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEB18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB18 Gene

Regulatory Elements for MAGEB18 Gene

Proteins for MAGEB18 Gene

  • Protein details for MAGEB18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M61-MAGBI_HUMAN
    Recommended name:
    Melanoma-associated antigen B18
    Protein Accession:
    Q96M61
    Secondary Accessions:

    Protein attributes for MAGEB18 Gene

    Size:
    343 amino acids
    Molecular mass:
    38533 Da
    Quaternary structure:
    • Interacts with LNX1.

neXtProt entry for MAGEB18 Gene

Proteomics data for MAGEB18 Gene at MOPED

Post-translational modifications for MAGEB18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEB18 Gene

Domains for MAGEB18 Gene

Protein Domains for MAGEB18 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEB18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96M61

UniProtKB/Swiss-Prot:

MAGBI_HUMAN
Domain:
  • Contains 1 MAGE domain.:
    • Q96M61
genes like me logo Genes that share domains with MAGEB18: view

No data available for Gene Families for MAGEB18 Gene

Function for MAGEB18 Gene

Molecular function for MAGEB18 Gene

UniProtKB/Swiss-Prot Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.

Gene Ontology (GO) - Molecular Function for MAGEB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MAGEB18: view
genes like me logo Genes that share phenotypes with MAGEB18: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MAGEB18 Gene

Localization for MAGEB18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEB18 Gene COMPARTMENTS Subcellular localization image for MAGEB18 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAGEB18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MAGEB18: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAGEB18 Gene

Pathways for MAGEB18 Gene

SuperPathways for MAGEB18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB18 Gene

None

No data available for Pathways by source for MAGEB18 Gene

Transcripts for MAGEB18 Gene

mRNA/cDNA for MAGEB18 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB18 Gene

Melanoma antigen family B, 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB18 Gene

No ASD Table

Relevant External Links for MAGEB18 Gene

GeneLoc Exon Structure for
MAGEB18
ECgene alternative splicing isoforms for
MAGEB18

Expression for MAGEB18 Gene

mRNA expression in normal human tissues for MAGEB18 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEB18 Gene

This gene is overexpressed in Testis (53.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEB18 Gene

SOURCE GeneReport for Unigene cluster for MAGEB18 Gene Hs.350683

genes like me logo Genes that share expressions with MAGEB18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAGEB18 Gene

Orthologs for MAGEB18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEB18 35
  • 99.42 (n)
  • 99.13 (a)
MAGEB18 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAGEB18 35
  • 77.38 (n)
  • 66.56 (a)
MAGEB18 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAGEB18 35
  • 78.95 (n)
  • 70.83 (a)
MAGEB18 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mageb18 35
  • 71.54 (n)
  • 60.54 (a)
Mageb18 16
Mageb18 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mageb18 35
  • 71.66 (n)
  • 60.88 (a)
Species with no ortholog for MAGEB18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB18 Gene

ENSEMBL:
Gene Tree for MAGEB18 (if available)
TreeFam:
Gene Tree for MAGEB18 (if available)

Paralogs for MAGEB18 Gene

Pseudogenes.org Pseudogenes for MAGEB18 Gene

genes like me logo Genes that share paralogs with MAGEB18: view

Variants for MAGEB18 Gene

Sequence variations from dbSNP and Humsavar for MAGEB18 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4898259 -- 26,140,692(+) CTTAG(C/T)TTACT utr-variant-3-prime
rs5943844 -- 26,138,941(+) ATCAA(C/T)TCAAC utr-variant-5-prime
rs5943845 -- 26,138,942(+) TCAAT(C/T)CAACT utr-variant-5-prime
rs5944315 -- 26,136,859(+) tgaaa(A/G)caaaa upstream-variant-2KB
rs5944316 -- 26,138,928(+) GGGTG(A/C)CCTCT utr-variant-5-prime

Relevant External Links for MAGEB18 Gene

HapMap Linkage Disequilibrium report
MAGEB18
Locus Specific Mutation Databases (LSDB)
MAGEB18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEB18 Gene

Disorders for MAGEB18 Gene

No disorders were found for MAGEB18 Gene.

No data available for UniProtKB/Swiss-Prot for MAGEB18 Gene

Publications for MAGEB18 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle J.M. … Potts P.R. (Mol. Cell 2010) 3 4
  4. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns S.L. … Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010) 3
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3

Products for MAGEB18 Gene

Sources for MAGEB18 Gene

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