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MAGEB18 Gene

protein-coding   GIFtS: 49
GCID: GC0XP026156

Melanoma Antigen Family B, 18

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Melanoma Antigen Family B, 181 2
MAGE-B18 Antigen2 3
Melanoma-Associated Antigen B182

External Ids:    HGNC: 285151   Entrez Gene: 2865142   Ensembl: ENSG000001767747   UniProtKB: Q96M613   

Export aliases for MAGEB18 gene to outside databases

Previous GC identifers: GC0XP025917 GC0XP026066 GC0XP023893


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAGEB18 Gene:
MAGEB18 (melanoma antigen family B, 18) is a protein-coding gene. An important paralog of this gene is MAGEC2.

UniProtKB/Swiss-Prot: MAGBI_HUMAN, Q96M61
Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.
Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate
complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAGEB18 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pax-5   HSF1 (long)   Pax-2   Nkx3-1 v1   Pax-2a   Evi-1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGEB18 promoter sequence
   Search Chromatin IP Primers for MAGEB18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGEB18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.3   Ensembl cytogenetic band:  Xp21.3   HGNC cytogenetic band: Xp21.3

MAGEB18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEB18 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP026156:  view genomic region     (about GC identifiers)

Start:
26,156,460 bp from pter      End:
26,158,853 bp from pter
Size:
2,394 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAGBI_HUMAN, Q96M61 (See protein sequence)
Recommended Name: Melanoma-associated antigen B18  
Size: 343 amino acids; 38533 Da
Subunit: Interacts with LNX1

Explore the universe of human proteins at neXtProt for MAGEB18: NX_Q96M61

Explore proteomics data for MAGEB18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAGEB18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775970.1  
    ENSEMBL proteins: 
     ENSP00000314543  

    MAGEB18 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry Q96M61

    ProtoNet protein and cluster: Q96M61

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGBI_HUMAN, Q96M61
    Similarity: Contains 1 MAGE domain


    Find genes that share domains with MAGEB18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAGBI_HUMAN, Q96M61
    Function: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.
    Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate
    complex

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with MAGEB18           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAGEB18:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAGEB18
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    miRNA
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    1 qRT-PCR Assays for microRNA that regulate MAGEB18:
    hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidMAGEB18 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAGEB18
    Predesigned siRNA for gene silencing in human, mouse, rat MAGEB18

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MAGEB18 (NM_173699)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGEB18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEB18

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with MAGEB18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAGEB18
    Interactions:

        Search GeneGlobe Interaction Network for MAGEB18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for MAGEB18 (Q96M611, 2, 3 ENSP000003145434) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNIP1Q150251, 2, 3, ENSP000003178914EBI-741835,EBI-357849 MINT-67152 I2D: score=5 STRING: ENSP00000317891
    LNX1Q8TBB11, 2, 3, ENSP000002639254EBI-741835,EBI-739832 MINT-67378 I2D: score=4 STRING: ENSP00000263925
    TP53P046372, 3, ENSP000002693054MINT-66234 MINT-2879329 I2D: score=4 STRING: ENSP00000269305
    TRIM37O949722, 3, ENSP000002622944MINT-66203 I2D: score=4 STRING: ENSP00000262294
    GABPB1Q065471, 3, ENSP000003702594EBI-741835,EBI-618165 I2D: score=3 STRING: ENSP00000370259
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAGEB18 (MAGBI)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAGEB18 gene: 
    NM_173699.3  

    Unigene Cluster for MAGEB18:

    Melanoma antigen family B, 18
    Hs.350683  [show with all ESTs]
    Unigene Representative Sequence: BC029525
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000325250(uc004dbq.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAGEB18 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MAGEB18:
    hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidMAGEB18 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat MAGEB18
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MAGEB18
      QuantiFast Probe-based Assays in human, mouse, rat MAGEB18

    Additional mRNA sequence: 

    AK057361.1 BC029525.1 

    1 DOTS entry:

    DT.100009708 

    4 AceView cDNA sequences:

    AK057361 BC029525 NM_173699 BI561895 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAGEB18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAAGTGAAA
    MAGEB18 Expression
    About this image

    MAGEB18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAGEB18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.350683
        Custom PCR Arrays for MAGEB18
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MAGEB18 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mageb181 , 5 melanoma antigen family B, 181, 5 71.54(n)1
    60.54(a)1
      X (40.62 cM)5
    2156411  NM_173783.31  NP_776144.11 
     921188795 


    ENSEMBL Gene Tree for MAGEB18 (if available)
    TreeFam Gene Tree for MAGEB18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAGEB18 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEB42  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGED12  
    MAGEA22  MAGEA32  MAGEB22  NDN2  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  
    MAGEA102  MAGEA2B2  MAGEB62  MAGEL22  TRO2  MAGEA112  NDNL22  MAGEF12  
    Selected SIMAP similar genes for MAGEB18 using alignment to 1 protein entry:     MAGBI_HUMAN(see all similar genes):
    MAGE-B1    MAGEB1    MAGEB16    MAGEB2    MAGEB4    MAGEC4
    MAGEB10    MAGEB17    MAGEA11    MAGEC1    MAGEH1    MAGEA8
    MAGEB3    MAGEA13P    MAGEA1    MAGEA9    MAGEA9B    MAGEB5

    Find genes that share paralogs with MAGEB18           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for MAGEB18
    PGOHUM00000241685 PGOHUM00000241686 PGOHUM00000241697


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAGEB18 (see all 96)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1385208781,2
    Cuntested126072623(+) GATTTG/AAAGGA 2 /L syn11Minor allele frequency- A:0.00NA 4488
    rs1121338891,2
    C,F--26069541(+) CACCAC/TGGCAT 1 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1113350731,2
    C,F--26069566(+) GACACA/GTGTTT 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1807979391,2
    --26069779(+) CATTGA/CTGAGA 1 -- us2k10--------
    rs2013895381,2
    --26069824(+) ACAAC-/AAATAA 1 -- us2k10--------
    rs1861937511,2
    --26069879(+) CAAAAA/GGTCAA 1 -- us2k10--------
    rs1908608041,2
    --26069889(+) AGAAAA/GTAACA 1 -- us2k10--------
    rs59443151,2
    C,F--26070005(+) tgaaaG/Acaaaa 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs1404739641,2
    --26070082(+) AAAGGC/TACATT 1 -- us2k10--------
    rs1839132521,2
    --26070323(+) ATAAGG/TGGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAGEB18 (26156460 - 26158853 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAGEB18: --
    Locus Specific Mutation Databases (LSDB): MAGEB18

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAGEB18
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGEB18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAGEB18 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MAGEB18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PubMed id 20864041)1, 2 Doyle J.M.... Potts P.R. (Mol. Cell 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    5. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1 Kerns S.L....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
    6. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
    7. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
    8. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 286514 HGNC: 28515 AceView: MGC33889 Ensembl:ENSG00000176774 euGenes: HUgn286514
    ECgene: MAGEB18 H-InvDB: MAGEB18

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAGEB18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEB18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAGEB18 gene:
    Search GeneIP for patents involving MAGEB18

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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      eBioscience FlowRNA Probe Sets
           
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