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MAGEB18 Gene

protein-coding GIFtS: 49

GC0XP026066

melanoma antigen family B, 18
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC33889 ^¹, ²
OTTHUMP00000023091 ^²

Descriptions
MAGE-B18 antigen ^³
melanoma antigen family B, 18 ^²

External Ids
HGNC: 28515¹
Entrez Gene: 286514²
UniProtKB: Q96M61³
Ensembl: ENSG00000176774⁷

Search outside databases for aliases for MAGEB18 gene

Previous GC identifer: GC0XP025917

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAGEB18 gene

Entrez Gene cytogenetic band: Xp21.3 Ensembl cytogenetic band: Xp21.3 HGNC cytogenetic band: Xp21.3

MAGEB18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP026066: (about GC identifiers)

Start:	26,066,381 bp from pter
End:	26,068,773 bp from pter
Size:	2,393 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011757.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MAGBI_HUMAN, Q96M61 (See protein sequence)

Recommended Name: Melanoma-associated antigen B18

Size: 343 amino acids; 38523 Da

REFSEQ proteins: NP_775970.1

ENSEMBL proteins:

ENSP00000314543

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MAGEB18)
	Human Recombinant Proteins from Abnova (MAGEB18)

OriGene Purified Recombinant Human Protein: MAGEB18

Antibodies for MAGEB18:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MAGEB18), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAGEB18)
	Novus Biologicals Antibodies for MAGEB18

Assays for MAGEB18:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q96M61

ProtoNet protein and cluster: Q96M61

1 Blocks protein family: IPB002190 MAGE protein

UniProtKB/Swiss-Prot: MAGBI_HUMAN, Q96M61

Similarity: Contains 1 MAGE domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGEB18)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173699

Applied Biosystems Silencer® siRNAs for MAGEB18

Sigma-Aldrich siRNA for MAGEB18

Sigma-Aldrich shRNA for MAGEB18

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MAGEB18
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_173699
Myc/DDK tagged cDNA clone in CMV expression vector: NM_173699
untagged cDNA clone in CMV expression vector: NM_173699

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_173699

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16189514

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Interacting proteins for MAGEB18 (Q96M61^{1, 2}) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
TNIP1 Q15025¹^,² EBI-741835, EBI-357849 MINT-67152 EBI-741835, EBI-357849 MINT-67152
TNIP1 Q15025¹^,² EBI-741835, EBI-357849 MINT-67152 EBI-741835, EBI-357849 MINT-67152
TP53 P04637² MINT-66234 MINT-2879329
LNX1 Q8TBB1² MINT-67378
TRIM37 O94972² MINT-66203
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGEB18

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAGEB18)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173699

Sigma-Aldrich siRNA for MAGEB18

Sigma-Aldrich shRNA for MAGEB18

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_173699

REFSEQ mRNAs for MAGEB18 gene:

NM_173699.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_173699

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173699
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_173699
                                 untagged cDNA clone in CMV expression vector: NM_173699

Additional cDNA sequence:

AK057361.1 BC029525.1

1 DOTS entry:

DT.100009708

4 AceView cDNA sequences:

NM_173699 AK057361 BC029525 BI561895

highest scoring ESTs for MAGEB18:

AK057361 BC029525 BI561895 NM_173699 DB335989 CV024659 DB021794

Unigene Cluster for MAGEB18:

Melanoma antigen family B, 18

Hs.350683 [show with all ESTs]

Unigene Representative Sequence: BC029525

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000325250

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MAGEB18 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAGEB18

¹ / ²

1 probe-set matching MAGEB18 gene

	Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
	1552913_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTAAGTGAAA

SOURCE GeneReport for Unigene cluster: Hs.350683

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for MAGEB18 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAGEB18¹	--	melanoma antigen family B, 18	78.23(n) 69.39(a)	491786 XM_548906.2 XP_548906.1
chimpanzee (Pan troglodytes)	MAGEB18¹	--	melanoma antigen family B, 18	99.51(n) 99.13(a)	473540 XM_528911.2 XP_528911.1
cow (Bos taurus)	MAGEB18¹	--	melanoma antigen family B, 18	77.78(n) 66.37(a)	532174 XM_610684.1 XP_610684.1
rat (Rattus norvegicus)	Mageb18¹	--	melanoma antigen family B, 18	71.96(n) 60.75(a)	317270 XM_228594.4 XP_228594.4
mouse (Mus musculus)	Mageb18^{1, 5}	X⁵	melanoma antigen family B, 18^{1, 5}	72.43(n)¹ 61.11(a)¹	215641¹ NM_173783.3¹ NP_776144.1¹ AK046641⁵ AL646048⁵ (see all 7)

About this table Species with no ortholog for MAGEB18

ENSEMBL Gene Tree for MAGEB18

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for MAGEB18 gene

MAGEB3² MAGEB5² MAGEB16² MAGEB10²

Pseudogenes

4 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/17 NCBI SNPs in MAGEB18 are shown (see all 17 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 23)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6526549^1,2	A,C,F,H	26066369(+)	`CGTTAT/AGCTGG`	1	--	ng5¹		7		NA EU EA WA	535
	rs4898259^1,2	A,C,F,H	26068730(+)	`CTTAGC/TTTACT`	1	--	ut3¹ ese³		11		NA EU EA WA	743
	rs5944317^1,2	A,C,F,H	26067141(+)	`CCTCCT/CCTGCC`	1	P/S	mis¹ ese³		4		EU EA WA	420
	rs5944316^1,2	A,C,F,H	26066966(+)	`GGGTGC/ACCTCT`	1	--	ut5¹		7		EU EA WA NA	529
--	rs5944320^1,2	A,C,F	26068414(+)	`TTGTTG/TCTTAT`	1	--	ut3¹ ese³		3		NA	117
--	rs5943844^1,2	A,C,F	26066979(+)	`ATCAAT/CTCAAC`	1	--	ut5¹		3		NA	110
--	rs5943845^1,2	A,C	26066980(+)	`TCAATC/TCAACT`	1	--	ut5¹		0	--	--	--	--
	rs6653745^1,2	H	26067592(+)	`CAGTGA/CTGAAG`	1	D/A	mis¹		4		EU EA WA	416
	rs5944318^1,2	A,C,F,H	26067713(+)	`TATGCT/CGATAG`	1	A/A	syn¹ ese³		4		EU EA WA	396
	rs5944319^1,2	C,F,H	26068154(+)	`ATCATC/ATTTGC`	1	--	int¹		4		EU EA WA	412

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HapMap Linkage Disequilibrium images for MAGEB18 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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5 PubMed articles for MAGEB18 gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)³ Lim J....Zoghbi H.Y. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 286514	HGNC: 28515	AceView: MGC33889	Ensembl:ENSG00000176774	euGenes: HUgn286514
ECgene: MAGEB18	H-InvDB: MAGEB18

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for MAGEB18	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MAGEB18
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MAGEB18:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAGEB18-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAGEB18		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MAGEB18		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MAGEB18)
	Antibodies (MAGEB18)
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	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (MAGEB18)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for MAGEB18

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MAGEB18

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MAGEB18 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for MAGEB18

Summaries
for MAGEB18

Genomic Location
for MAGEB18

Proteins
for MAGEB18

Protein Domains/
Families
for MAGEB18

Gene Function
for MAGEB18

Pathways & Interactions
for MAGEB18

Drugs & Compounds
for MAGEB18

Transcripts
for MAGEB18

Expression
for MAGEB18

Orthologs
for MAGEB18

Paralogs
for MAGEB18

SNPs/Variants
for MAGEB18

Disorders & Mutations
for MAGEB18

Medical News
for MAGEB18

Publications
for MAGEB18

Search for MAGEB18

Genome Databases showing MAGEB18

Other Databases showing MAGEB18

Specialized Databases showing MAGEB18

Licensable Technologies
for MAGEB18

Services
for MAGEB18

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAGEB18 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor MAGEB18

Summariesfor MAGEB18

Genomic Locationfor MAGEB18

Proteinsfor MAGEB18

Protein Domains/Familiesfor MAGEB18

Gene Functionfor MAGEB18

Pathways & Interactionsfor MAGEB18

Drugs & Compoundsfor MAGEB18

Transcriptsfor MAGEB18

Expression for MAGEB18

Orthologsfor MAGEB18

Paralogsfor MAGEB18

SNPs/Variantsfor MAGEB18

Disorders & Mutationsfor MAGEB18

Medical Newsfor MAGEB18

Publicationsfor MAGEB18

Search for MAGEB18

Genome Databases showing MAGEB18

Other Databases showing MAGEB18

Specialized Databases showing MAGEB18

Licensable Technologiesfor MAGEB18

Servicesfor MAGEB18

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAGEB18

Summaries
for MAGEB18

Genomic Location
for MAGEB18

Proteins
for MAGEB18

Protein Domains/
Families
for MAGEB18

Gene Function
for MAGEB18

Pathways & Interactions
for MAGEB18

Drugs & Compounds
for MAGEB18

Transcripts
for MAGEB18

Expression
for MAGEB18

Orthologs
for MAGEB18

Paralogs
for MAGEB18

SNPs/Variants
for MAGEB18

Disorders & Mutations
for MAGEB18

Medical News
for MAGEB18

Publications
for MAGEB18

Licensable Technologies
for MAGEB18

Services
for MAGEB18