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MAGEB17 Gene(Protein Coding)

MAGE Family Member B17

GCID:
GC0XP016183
GIFtS:
36
Genes Participants
UDN Logo

Aliases for MAGEB17 Gene

Aliases for MAGEB17 Gene

  • MAGE Family Member B17 2 3 5
  • Melanoma Antigen Family B, 17 (Pseudogene) 2
  • Melanoma Antigen Family B17 2

External Ids for MAGEB17 Gene

Previous GeneCards Identifiers for MAGEB17 Gene

  • GC0XM015945
  • GC0XU900743
  • GC0XP016095
  • GC0XP013939

Summaries for MAGEB17 Gene

GeneCards Summary for MAGEB17 Gene

MAGEB17 (MAGE Family Member B17) is a Protein Coding gene. An important paralog of this gene is MAGEB4.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB17 Gene

Genomics for MAGEB17 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MAGEB17 Gene

Enhancers for MAGEB17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG016215 0.7 ENCODE dbSUPER 12.8 +48.5 48538 1.9 CHD7 ATF2 EZH2 LOC102724124 MAGEB17 ZRSR2 RPL6P30 GC0XP016374
GH0XG016198 0.6 ENCODE dbSUPER 13.5 +31.8 31819 1.1 SPI1 LOC102724124 MAGEB17 ZRSR2 RPL6P30
GH0XG016211 0.6 dbSUPER 12.5 +44.7 44706 0.6 CTCF JUND SMC3 FOS REST RAD21 MAGEB17 LOC102724124 GRPR ZRSR2 RPL6P30 GC0XP016374
GH0XG016122 0.7 ENCODE 0.3 -44.0 -44016 1.0 CTCF ATF1 WRNIP1 TRIM22 REST RAD21 RFX5 NFYB ZNF143 SMC3 GRPR MAGEB17
GH0XG016159 0.5 ENCODE 0.4 -6.7 -6650 2.1 JUND SIN3A FOS TCF7L2 GRPR ZRSR2 MAGEB17
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAGEB17 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MAGEB17 gene promoter:

Genomic Location for MAGEB17 Gene

Chromosome:
X
Start:
16,167,481 bp from pter
End:
16,172,097 bp from pter
Size:
4,617 bases
Orientation:
Plus strand

Genomic View for MAGEB17 Gene

Genes around MAGEB17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEB17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEB17 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAGEB17 Gene

Proteins for MAGEB17 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MAGEB17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MXT2-MAGBH_HUMAN
    Recommended name:
    Melanoma-associated antigen B17
    Protein Accession:
    A8MXT2
    Secondary Accessions:
    • A6NE98

    Protein attributes for MAGEB17 Gene

    Size:
    336 amino acids
    Molecular mass:
    37578 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW98911.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MAGEB17 Gene

Protein Expression for MAGEB17 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MAGEB17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEB17 Gene

Domains & Families for MAGEB17 Gene

Gene Families for MAGEB17 Gene

HGNC:

Protein Domains for MAGEB17 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEB17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEB17: view

No data available for UniProtKB/Swiss-Prot for MAGEB17 Gene

Function for MAGEB17 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes for MAGEB17 Gene

GenomeRNAi human phenotypes for MAGEB17:
genes like me logo Genes that share phenotypes with MAGEB17: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEB17 Gene

Localization for MAGEB17 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEB17 gene
Compartment Confidence
nucleus 3
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEB17 Gene

Pathways & Interactions for MAGEB17 Gene

SuperPathways for MAGEB17 Gene

PathCards logo More details on SuperPathways for MAGEB17
No Data Available

Interacting Proteins for MAGEB17 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000382883%0d%0a9606.ENSP00000354957%0d%0a9606.ENSP00000355077%0d%0a9606.ENSP00000287437%0d%0a9606.ENSP00000435619%0d%0a9606.ENSP00000358019%0d%0a
Selected Interacting proteins: ENSP00000382883 for MAGEB17 Gene via STRING

Gene Ontology (GO) - Biological Process for MAGEB17 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEB17 Gene

Drugs & Compounds for MAGEB17 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MAGEB17 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MAGEB17 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB17 Gene

No ASD Table

Relevant External Links for MAGEB17 Gene

GeneLoc Exon Structure for
MAGEB17
ECgene alternative splicing isoforms for
MAGEB17

Expression for MAGEB17 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEB17 Gene

mRNA expression in normal human tissues for MAGEB17 Gene
mRNA expression by GTEx for MAGEB17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEB17 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x9.3), Pancreas (x7.9), Testis (x7.8), and Esophagus - Muscularis (x6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEB17 Gene



NURSA nuclear receptor signaling pathways regulating expression of MAGEB17 Gene:

MAGEB17
genes like me logo Genes that share expression patterns with MAGEB17: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEB17 Gene

Orthologs for MAGEB17 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MAGEB17 34 35
  • 98.31 (n)
cow
(Bos Taurus)
 Mammalia LOC618686 34
  • 68.94 (n)
-- 35
  • 49 (a)
 ManyToMany
dog
(Canis familiaris)
 Mammalia LOC100684355 34
  • 65.22 (n)
MAGEB10 35
  • 47 (a)
 ManyToMany
mouse
(Mus musculus)
 Mammalia Gm5072 34 16
  • 61.24 (n)
Species where no ortholog for MAGEB17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB17 Gene

ENSEMBL:
Gene Tree for MAGEB17 (if available)
TreeFam:
Gene Tree for MAGEB17 (if available)

Paralogs for MAGEB17 Gene

Variants for MAGEB17 Gene

Sequence variations from dbSNP and Humsavar for MAGEB17 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000823851 -- 16,171,188(+) ACGCT(A/G)CGAGT reference, missense
rs1000925813 -- 16,170,786(+) AGCCA(C/T)GCTGA reference, missense
rs1000966987 -- 16,168,881(+) AGAAA(A/G)GAGTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001510017 -- 16,166,451(+) TCCTG(A/G)GCCCC intron-variant, upstream-variant-2KB
rs1001972277 -- 16,170,766(+) AAAGA(A/G)CCCAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MAGEB17 Gene

Variant ID Type Subtype PubMed ID
nsv436917 CNV insertion 17901297

Variation tolerance for MAGEB17 Gene

Gene Damage Index Score: 0.71; 15.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEB17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEB17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEB17 Gene

Disorders for MAGEB17 Gene

Relevant External Links for MAGEB17

Genetic Association Database (GAD)
MAGEB17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEB17

No disorders were found for MAGEB17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGEB17 Gene

Publications for MAGEB17 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. An overview of the MAGE gene family with the identification of all human members of the family. (PMID: 11454705) Chomez P. … Lucas S. (Cancer Res. 2001) 2 3 64

Products for MAGEB17 Gene

Sources for MAGEB17 Gene

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