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MAGEB17 Gene

protein-coding GIFtS: 28
GCID: GC0XP016183

Melanoma Antigen Family B, 17

(Previous names: melanoma antigen family B, 17 (pseudogene))

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Melanoma Antigen Family B, 17¹ ²
Melanoma Antigen Family B, 17 (Pseudogene)¹ ²
Melanoma-Associated Antigen B17²

External Ids:	HGNC: 17418¹	Entrez Gene: 645864²	Ensembl: ENSG00000182798⁷	OMIM: 300763⁵	UniProtKB: A8MXT2³

Export aliases for MAGEB17 gene to outside databases

Previous GC identifers: GC0XM015945 GC0XU900743 GC0XP016095 GC0XP013939

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAGEB17 Gene:

MAGEB17 (melanoma antigen family B, 17) is a protein-coding gene. Diseases associated with MAGEB17 include melanoma. An important paralog of this gene is MAGEC2.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Regulatory transcription factor binding sites in the MAGEB17 gene promoter:
HFH-3 STAT1 FOXI1 AREB6 FOXJ2 (long isoform) HOXA5 FOXJ2 ATF6
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for MAGEB17

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGEB17

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.2

MAGEB17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEB17 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP016183: view genomic region (about GC identifiers)

Start:	16,185,604 bp from pter	End:	16,189,587 bp from pter
Size:	3,984 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MAGBH_HUMAN, A8MXT2 (See protein sequence)

Recommended Name: Melanoma-associated antigen B17

Size: 457 amino acids; 51128 Da

Caution: Formerly thought to be the product of a pseudogene, although could be a bona fide protein. However,

scarce EST evidence confirms only the C-terminal sequence. The N-terminal sequence is based on a computational

prediction and so it is uncertain whether Met-1 or Met-122 is the initiator

Secondary accessions: A6NE98

Explore the universe of human proteins at neXtProt for MAGEB17: NX_A8MXT2

Explore proteomics data for MAGEB17 at MOPED

See MAGEB17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001264236.1

ENSEMBL proteins:

ENSP00000382884 ENSP00000382883 ENSP00000328274

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:

IPR021072 Melanoma_ass_antigen_N

IPR002190 MAGE

Graphical View of Domain Structure for InterPro Entry A8MXT2

ProtoNet protein and cluster: A8MXT2

UniProtKB/Swiss-Prot: MAGBH_HUMAN, A8MXT2

Similarity: Contains 1 MAGE domain

MAGEB17 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	3
cytosol	1
endoplasmic reticulum	1
mitochondrion	1
plasma membrane	1

About this image

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for MAGEB17
Interactions:

Search GeneGlobe Interaction Network for MAGEB17

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MAGEB17 gene:

NM_001277307.1

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000400004 ENST00000400003 ENST00000329538

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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MAGEB17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

MAGEB17 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Adipose (Muscoskeletal System)
Mesenchymal Stem Cells Subcutaneous White Adipose

Mesenchymal Stem Cells
Mesenchymal Stem Cells Subcutaneous White Adipose

MAGEB17 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

MAGEB17 Protein Expression

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEB17 gene from Selected species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Mageb5⁵ Gm5072¹	melanoma antigen, family B, 5⁵ predicted gene 5072¹	61.24(n)¹ 46.1(a)¹		X (40.50 cM)⁵ 278167¹ NM_001114678.1¹ NP_001108150.1¹ 91779544⁵

ENSEMBL Gene Tree for MAGEB17 (if available)
TreeFam Gene Tree for MAGEB17 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MAGEB17 gene

MAGEC2² MAGEA9B² MAGEB5² MAGEB16² MAGEB1² MAGEB4² MAGEC1² MAGED4²

MAGEA8² MAGED2² MAGEA12² MAGEA9² MAGEB10² MAGEA6² MAGED1² MAGEA2²

MAGEA3² MAGEB2² NDN² MAGEB3² MAGED4B² MAGEA4² MAGEA1² MAGEA10²

MAGEB18² MAGEA2B² MAGEB6² MAGEL2² TRO² MAGEA11² NDNL2² MAGEF1²

Selected SIMAP similar genes for MAGEB17 using alignment to 1 protein entry: MAGBH_HUMAN(see all similar genes):

MAGE-B1 MAGEB1 MAGEB2 MAGEC4 MAGEB3 MAGEB4

MAGEC1 MAGEB10 MAGEB18 MAGEH1 MAGEB5 MAGEC2

MAGEE1 MAGEA9 MAGEA9B MAGEB16 MAGEA1 MAGEA8

MAGEB17 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139111658^1,2	C	--	16098882(+)	`GGAACC/TATGAC`	1	--	us2k¹		0	--	--	--	--
rs186428658^1,2	C	--	16098900(+)	`CCTGTA/GGTCAA`	1	--	us2k¹		0	--	--	--	--
rs144092823^1,2		--	16098966(+)	`TTGTCA/TTAGGG`	1	--	us2k¹		0	--	--	--	--
rs12559221^1,2	C,F,A,H	--	16098990(+)	`AGGAAG/ACATGA`	1	--	us2k¹		9		NS EA WA NA CSA	431
rs12557236^1,2	C,F,A,H	--	16099006(+)	`GCTGGT/CGAATG`	1	--	us2k¹		13		NS EA NA WA CSA	562
rs73204608^1,2		--	16099017(+)	`CCATGA/GTAAGA`	1	--	us2k¹		0	--	--	--	--
rs75891152^1,2	C	--	16099073(+)	`TTTTT-/T/TTT CTTGA`	2	--	us2k¹ cds¹		0	--	--	--	--
rs144897399^1,2		--	16099101(+)	`TCGCCC/TATGCT`	1	--	us2k¹		0	--	--	--	--
rs145165790^1,2		--	16099112(+)	`GGAGTA/GCAGTG`	1	--	us2k¹		0	--	--	--	--
rs149132425^1,2		--	16099151(+)	`CCTCCC/TGGGTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MAGEB17 (16185604 - 16189587 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for MAGEB17: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300763 OMIM disorders: --

1 disease for MAGEB17:
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melanoma

MAGEB17 for disorders About GeneDecksing

Genetic Association Database (GAD): MAGEB17

Export disorders for MAGEB17 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MAGEB17 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MAGEB17)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (Nature 2005)
An overview of the MAGE gene family with the identification of all human members of the family. (PubMed id 11454705)^{1, 3} Chomez P.... Lucas S. (Cancer Res. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 645864	HGNC: 17418	Ensembl:ENSG00000182798	euGenes: HUgn645864	ECgene: MAGEB17
H-InvDB: MAGEB17

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MAGEB17	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MAGEB17	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MAGEB17 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MAGEB17 gene:
Search GeneIP for patents involving MAGEB17

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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MAGEB17 Gene

Melanoma Antigen Family B, 17

Aliases
for MAGEB17 gene

Summaries
for MAGEB17 gene

Genomic Views
for MAGEB17 gene

Proteins
for MAGEB17 gene

MAGEB17 Human Recombinant Protein Products:

MAGEB17 Antibody Products:

MAGEB17 Assay Products:

Domains /
Families
for MAGEB17 gene

Function
for MAGEB17 gene

Localization
for MAGEB17 gene

Pathways & Interactions
for MAGEB17 gene

Drugs & Compounds
for MAGEB17 gene

Transcripts
for MAGEB17 gene

Expression
for MAGEB17 gene

Orthologs
for MAGEB17 gene

Paralogs
for MAGEB17 gene

Genomic Variants
for MAGEB17 gene

Disorders / Diseases
for MAGEB17 gene

Publications
for MAGEB17 gene

External Searches for MAGEB17 gene

Genome Databases showing MAGEB17 gene

Other Databases showing MAGEB17 gene

Specialized Databases showing MAGEB17 gene

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for MAGEB17 gene

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for MAGEB17 gene

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MAGEB17 Gene

Melanoma Antigen Family B, 17

Aliasesfor MAGEB17 gene

Summariesfor MAGEB17 gene

Genomic Viewsfor MAGEB17 gene

Proteinsfor MAGEB17 gene

MAGEB17 Human Recombinant Protein Products:

MAGEB17 Antibody Products:

MAGEB17 Assay Products:

Domains /Familiesfor MAGEB17 gene

Functionfor MAGEB17 gene

Localizationfor MAGEB17 gene

Pathways & Interactionsfor MAGEB17 gene

Drugs & Compoundsfor MAGEB17 gene

Transcriptsfor MAGEB17 gene

Expression for MAGEB17 gene

Orthologsfor MAGEB17 gene

Paralogsfor MAGEB17 gene

Genomic Variantsfor MAGEB17 gene

Disorders / Diseasesfor MAGEB17 gene

Publicationsfor MAGEB17 gene

External Searches for MAGEB17 gene

Genome Databases showing MAGEB17 gene

Other Databases showing MAGEB17 gene

Specialized Databases showing MAGEB17 gene

Intellectual Propertyfor MAGEB17 gene

Productsfor MAGEB17 gene

View Random Gene

Aliases
for MAGEB17 gene

Summaries
for MAGEB17 gene

Genomic Views
for MAGEB17 gene

Proteins
for MAGEB17 gene

Domains /
Families
for MAGEB17 gene

Function
for MAGEB17 gene

Localization
for MAGEB17 gene

Pathways & Interactions
for MAGEB17 gene

Drugs & Compounds
for MAGEB17 gene

Transcripts
for MAGEB17 gene

Expression
for MAGEB17 gene

Orthologs
for MAGEB17 gene

Paralogs
for MAGEB17 gene

Genomic Variants
for MAGEB17 gene

Disorders / Diseases
for MAGEB17 gene

Publications
for MAGEB17 gene

Intellectual Property
for MAGEB17 gene

Products
for MAGEB17 gene