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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGEB17 Gene

protein-coding   GIFtS: 28
GCID: GC0XP016183

Melanoma Antigen Family B, 17

(Previous names: melanoma antigen family B, 17 (pseudogene))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Melanoma Antigen Family B, 171 2
Melanoma Antigen Family B, 17 (Pseudogene)1 2
Melanoma-Associated Antigen B172

External Ids:    HGNC: 174181   Entrez Gene: 6458642   Ensembl: ENSG000001827987   OMIM: 3007635   UniProtKB: A8MXT23   

Export aliases for MAGEB17 gene to outside databases

Previous GC identifers: GC0XM015945 GC0XU900743 GC0XP016095 GC0XP013939


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MAGEB17 Gene: 
MAGEB17 (melanoma antigen family B, 17) is a protein-coding gene. Diseases associated with MAGEB17 include melanoma. An important paralog of this gene is MAGEC2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGEB17 gene promoter:
         HFH-3   STAT1   FOXI1   AREB6   FOXJ2 (long isoform)   HOXA5   FOXJ2   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MAGEB17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEB17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.2

MAGEB17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEB17 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP016183:  view genomic region     (about GC identifiers)

Start:
16,185,604 bp from pter      End:
16,189,587 bp from pter
Size:
3,984 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAGBH_HUMAN, A8MXT2 (See protein sequence)
Recommended Name: Melanoma-associated antigen B17  
Size: 457 amino acids; 51128 Da
Caution: Formerly thought to be the product of a pseudogene, although could be a bona fide protein. However,
scarce EST evidence confirms only the C-terminal sequence. The N-terminal sequence is based on a computational
prediction and so it is uncertain whether Met-1 or Met-122 is the initiator
Secondary accessions: A6NE98

Explore the universe of human proteins at neXtProt for MAGEB17: NX_A8MXT2

Explore proteomics data for MAGEB17 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A8MXT2

  • MAGEB17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAGEB17 Protein Expression
    REFSEQ proteins: NP_001264236.1  
    ENSEMBL proteins: 
     ENSP00000382884   ENSP00000382883   ENSP00000328274  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry A8MXT2

    ProtoNet protein and cluster: A8MXT2

    UniProtKB/Swiss-Prot: MAGBH_HUMAN, A8MXT2
    Similarity: Contains 1 MAGE domain


    MAGEB17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEB17

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAGEB17 (MAGBH)

    Search CenterWatch for drugs/clinical trials and news about MAGEB17 / MAGBH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for MAGEB17 gene: 
    NM_001277307.1  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400004 ENST00000400003 ENST00000329538
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGEB17 expression in normal human tissues (normalized intensities)      MAGEB17 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAGEB17 Expression
    About this image


    MAGEB17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose

    See MAGEB17 Protein Expression from SPIRE MOPED and PaxDB    SABiosciences Custom PCR Arrays for MAGEB17
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for MAGEB17 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mageb51 , 5 melanoma antigen, family B, 51, 5 55.08(n)1
    42.38(a)1
      X (40.50 cM)5
    742711  NM_028847.11  NP_083123.11 
     917795445 


    ENSEMBL Gene Tree for MAGEB17 (if available)
    TreeFam Gene Tree for MAGEB17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGEB17 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEB42  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB102  MAGEA62  MAGED12  MAGEA22  
    MAGEA32  MAGEB22  NDN2  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  MAGEA102  
    MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  MAGEA112  NDNL22  MAGEF12  
    18/33 SIMAP similar genes for MAGEB17 using alignment to 1 protein entry:     MAGBH_HUMAN(see all similar genes):
    MAGE-B1    MAGEB1    MAGEB2    MAGEC4    MAGEB3    MAGEB4
    MAGEC1    MAGEB10    MAGEB18    MAGEH1    MAGEB5    MAGEC2
    MAGEE1    MAGEA9    MAGEA9B    MAGEB16    MAGEA1    MAGEA8

    MAGEB17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/90 SNPs in MAGEB17 are shown (see all 90)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391116581,2
    C--16098882(+) GGAACC/TATGAC 1 -- us2k10--------
    rs1864286581,2
    C--16098900(+) CCTGTA/GGTCAA 1 -- us2k10--------
    rs1440928231,2
    --16098966(+) TTGTCA/TTAGGG 1 -- us2k10--------
    rs125592211,2
    C,F,A,H--16098990(+) AGGAAG/ACATGA 1 -- us2k19Minor allele frequency- A:0.20NS EA WA NA CSA 431
    rs125572361,2
    C,F,A,H--16099006(+) GCTGGT/CGAATG 1 -- us2k113Minor allele frequency- C:0.25NS EA NA WA CSA 562
    rs732046081,2
    --16099017(+) CCATGA/GTAAGA 1 -- us2k10--------
    rs758911521,2
    C--16099073(+) TTTTT-/T/TTT 
            
    CTTGA
    2 -- us2k1 cds10--------
    rs1448973991,2
    --16099101(+) TCGCCC/TATGCT 1 -- us2k10--------
    rs1451657901,2
    --16099112(+) GGAGTA/GCAGTG 1 -- us2k10--------
    rs1491324251,2
    --16099151(+) CCTCCC/TGGGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAGEB17 (16185604 - 16189587 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAGEB17: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAGEB17
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGEB17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300763    OMIM disorders: --

    2 diseases for MAGEB17:    About MalaCards
    melanoma    


    MAGEB17 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MAGEB17

    Export disorders for MAGEB17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGEB17 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MAGEB17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. An overview of the MAGE gene family with the identification of all human members of the family. (PubMed id 11454705)1, 3 Chomez P....Lucas S. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 645864 HGNC: 17418 Ensembl:ENSG00000182798 euGenes: HUgn645864 ECgene: MAGEB17
    H-InvDB: MAGEB17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAGEB17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEB17 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAGEB17 gene:
    Search GeneIP for patents involving MAGEB17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Search LifeMap BioReagents cell lines for MAGEB17
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB17
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MAGEB17
     Browse SwitchGear Promoter luciferase reporter plasmids for MAGEB17
     Search ThermoFisher Antibodies for MAGEB17
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAGEB17
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MAGEB17
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAGEB17
    Customized:
     lentivirus for stable overexpression of MAGEB17
     lentivirus expression plasmids for stable overexpression of MAGEB17
     adenovirus for overexpression of MAGEB17
     Search LSBio for Antibodies for MAGEB17
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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