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MAGEB16 Gene

protein-coding   GIFtS: 32

GC0XP035726
melanoma antigen family B, 16
(Previous names: melanoma antigen family B, 16 (pseudogene) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for MAGEB16

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
OTTHUMP00000159282 2
OTTHUMP00000159283 2
OTTHUMP00000159284 2
OTTHUMP00000159285 2
Descriptions
MAGE-B16 antigen 3
melanoma antigen family B, 16 2
melanoma antigen family B, 16 (pseudogene) 1, 2
External Ids
HGNC: 211881
Entrez Gene: 1396042
UniProtKB: A2A3683
Ensembl: ENSG000001890237
Search outside databases for aliases for MAGEB16 gene

Previous GC identifer: GC0XU900549

Summaries
for MAGEB16

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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   --

Genomic Location
for MAGEB16

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.1   Ensembl cytogenetic band:  Xp21.1   HGNC chromosome: X

MAGEB16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP035726:     (about GC identifiers)

Start:
 35,726,380 bp from pter
End:
 35,731,773 bp from pter
Size:
 5,394 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000023.9  NT_011757.15  

Proteins
for MAGEB16

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: MAGBG_HUMAN, A2A368 (See protein sequence)
Recommended Name: Melanoma-associated antigen B16  
Size: 324 amino acids; 36178 Da
Sequence caution: Sequence=CAM20853.1; Type=Erroneous gene model prediction;
Secondary accessions: A8MU30

REFSEQ proteins: NP_001093391.1  

ENSEMBL proteins: 
ENSP00000382871 ENSP00000382869 ENSP00000382870 ENSP00000382874 ENSP00000382867 


Human Recombinant Proteins 
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Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for MAGEB16: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for MAGEB16

Assays for MAGEB16: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for MAGEB16

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR002190 MAGE


   GeneDecks  MAGEB16 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry A2A368

ProtoNet protein and cluster: A2A368

UniProtKB/Swiss-Prot: MAGBG_HUMAN, A2A368
Similarity: Contains 1 MAGE domain

Gene Function
for MAGEB16

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (MAGEB16)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for MAGEB16

              Sigma-Aldrich siRNA for MAGEB16  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001099921
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001099921
                                 untagged cDNA clone in CMV expression vector: NM_001099921 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001099921

Pathways & Interactions
for MAGEB16

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

Drugs & Compounds
for MAGEB16

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGEB16

Transcripts
for MAGEB16

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (MAGEB16)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Sigma-Aldrich siRNA for MAGEB16  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001099921  

REFSEQ mRNAs for MAGEB16 gene: 

NM_001099921.1   


              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001099921
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001099921
                                 untagged cDNA clone in CMV expression vector: NM_001099921 

Unigene Cluster for MAGEB16:

Melanoma antigen family B, 16
Hs.700562
Unigene Representative Sequence: NM_001099921


GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations:
ENST00000399989  ENST00000399987  ENST00000399988  ENST00000399992  ENST00000399985  

Expression
for MAGEB16

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MAGEB16 expression in normal and diseased human tissues

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: ACATTGCTAA

SOURCE GeneReport for Unigene cluster: Hs.700562

Orthologs
for MAGEB16

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for MAGEB16 gene from 5 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 MAGEB161   -- melanoma antigen family B, 16 72.76(n)
60.22(a)		 491811  XM_548931.2  XP_548931.2 
chimpanzee
(Pan troglodytes)		 MAGEB161   -- melanoma antigen family B, 16 98.46(n)
96.91(a)		 473559  XM_528931.2  XP_528931.2 
cow
(Bos taurus)		 MAGEB161   -- melanoma antigen family B, 16 77.5(n)
63.47(a)		 528275  XM_606691.2  XP_606691.2 
rat
(Rattus norvegicus)		 Mageb161   -- melanoma antigen family B, 16 67.41(n)
56.87(a)		 317274  NM_001025013.1  NP_001020184.1 
mouse
(Mus musculus)		 2410003J06Rik1, 5 X5
 RIKEN cDNA 2410003J06 gene1, 5 66.99(n)1
56.41(a)1		 719671  XM_135953.71  XP_135953.11 
 AF1638655  AI4483805  (see all 14)
About this table        Species with no ortholog for MAGEB16

ENSEMBL Gene Tree for MAGEB16

Paralogs
for MAGEB16

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for MAGEB16 gene
MAGEB32  MAGEB52  MAGEB102  MAGEB182  

SNPs/Variants
for MAGEB16

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/53 NCBI SNPs in MAGEB16 are shown (see all 53 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 51)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs21497011,2
A,C,F,H,O35731479(+) TTTAGA/GTAGTT 1 -- ut317Minor allele frequency- G:0.34NA EU EA WA 560
rs14109611,2
A,C,F,H35730346(+) AGACCT/CTCCTC 1 F/L mis1 trp310Minor allele frequency- C:0.31NA EA EU WA 785
rs48293921,2
A,C,F,H35731048(+) CTGCAT/CGATAT 1 X/R non1 ese38Minor allele frequency- C:0.30EU EA WA 626
rs59734851,2
A,C,F,H35725639(+) TCTAAA/GGGAAT 1 -- ng517Minor allele frequency- G:0.06EU EA WA NA 538
rs15714711,2
A,C,F,H35731684(+) GCAAAA/GGTTTT 1 -- ut318Minor allele frequency- G:0.29EU EA WA 624
rs59719751,2
A,C,F,H35726454(+) GTGTCG/AAGGTA 1 -- ut517Minor allele frequency- A:0.09EU EA WA NA 562
--
rs48293911,2
A,C,F,H35730977(+) CAGAAA/AT    
   /GA/TGCTCA 		3 M/K M/N M/R mis1 fra14EU EA WA 412
rs14109621,2
A,C,F,H35730617(+) CAAGTA/GTCAGA 1 C/Y mis1 ese311Minor allele frequency- G:0.34EU EA WA NA 836
rs59734881,2
A,C,F,H35730716(+) TGAGCG/ACCTAG 1 R/H mis1 ese311Minor allele frequency- A:0.33EU EA WA NA 874
rs59719771,2
A,C,H35732241(+) AATTCG/AGGTGT 1 -- ng314Minor allele frequency- A:0.00EU EA WA 404
About this table

HapMap Linkage Disequilibrium images for MAGEB16 (up to first 250kb)

Disorders & Mutations
for MAGEB16

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 300762

Medical News
for MAGEB16

(Possibly Related Articles in Doctor's Guide)
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   --

Publications
for MAGEB16

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

2 PubMed articles for MAGEB16 gene:

Search for MAGEB16

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing MAGEB16

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 139604 HGNC: 21188 Ensembl:ENSG00000189023 euGenes: HUgn139604 ECgene: MAGEB16
H-InvDB: MAGEB16

Other Databases showing MAGEB16

(According to HUGE)
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   --

Specialized Databases showing MAGEB16

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
ATLAS Chromosomes in Cancer entry for MAGEB16 Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies
for MAGEB16

(Available from WIS Yeda, Salk, Tufts)
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  --

Services
for MAGEB16

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for MAGEB16:
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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