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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGEB16 Gene

protein-coding   GIFtS: 35
GCID: GC0XP035816

Melanoma Antigen Family B, 16

(Previous names: melanoma antigen family B, 16 (pseudogene))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Melanoma Antigen Family B, 161 2
Melanoma Antigen Family B, 16 (Pseudogene)1 2
MAGE-B16 Antigen2 3
Melanoma-Associated Antigen B162

External Ids:    HGNC: 211881   Entrez Gene: 1396042   Ensembl: ENSG000001890237   OMIM: 3007625   UniProtKB: A2A3683   

Export aliases for MAGEB16 gene to outside databases

Previous GC identifers: GC0XU900549 GC0XP035726 GC0XP033557


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MAGEB16 Gene: 
MAGEB16 (melanoma antigen family B, 16) is a protein-coding gene. Diseases associated with MAGEB16 include melanoma. An important paralog of this gene is MAGEC2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGEB16 gene promoter:
         C/EBPbeta   Pax-2   IRF-1   Pax-2a   C/EBPalpha   POU2F1   Pax-2b   POU2F1a   PPAR-gamma2   LyF-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MAGEB16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEB16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.1   Ensembl cytogenetic band:  Xp21.1   HGNC cytogenetic band: Xp21.1

MAGEB16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEB16 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP035816:  view genomic region     (about GC identifiers)

Start:
35,816,459 bp from pter      End:
35,821,852 bp from pter
Size:
5,394 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAGBG_HUMAN, A2A368 (See protein sequence)
Recommended Name: Melanoma-associated antigen B16  
Size: 324 amino acids; 36178 Da
Sequence caution: Sequence=CAM20853.1; Type=Erroneous gene model prediction;
Secondary accessions: A8MU30

Explore the universe of human proteins at neXtProt for MAGEB16: NX_A2A368

Explore proteomics data for MAGEB16 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A2A368

  • MAGEB16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAGEB16 Protein Expression
    REFSEQ proteins: NP_001093391.1  
    ENSEMBL proteins: 
     ENSP00000382870   ENSP00000382874   ENSP00000382869   ENSP00000382871   ENSP00000382867  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry A2A368

    ProtoNet protein and cluster: A2A368

    UniProtKB/Swiss-Prot: MAGBG_HUMAN, A2A368
    Similarity: Contains 1 MAGE domain


    MAGEB16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEB16

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAGEB16 (MAGBG)

    Search CenterWatch for drugs/clinical trials and news about MAGEB16 / MAGBG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for MAGEB16 gene: 
    NM_001099921.1  

    Unigene Cluster for MAGEB16:

    Melanoma antigen family B, 16
    Hs.700562
    Unigene Representative Sequence: NM_001099921
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399988 ENST00000399992 ENST00000399987 ENST00000399989(uc010ngt.1)
    ENST00000399985
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEB16

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGEB16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATTGCTAA
    MAGEB16 Expression
    About this image


    See MAGEB16 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.700562
        SABiosciences Custom PCR Arrays for MAGEB16
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for MAGEB16 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mageb161 , 5 melanoma antigen family B, 161, 5 66.99(n)1
    56.41(a)1
      X (38.38 cM)5
    719671  NM_001113734.11  NP_001107206.11 
     796232315 


    ENSEMBL Gene Tree for MAGEB16 (if available)
    TreeFam Gene Tree for MAGEB16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGEB16 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB12  MAGEB42  MAGEC12  MAGED42  MAGEA82  
    MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGED12  MAGEA22  
    MAGEA32  MAGEB22  NDN2  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  MAGEA102  
    MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  MAGEA112  NDNL22  MAGEF12  
    18/36 SIMAP similar genes for MAGEB16 using alignment to 1 protein entry:     MAGBG_HUMAN(see all similar genes):
    MAGEH1    MAGE-B1    MAGEA8    MAGEB1    MAGEB18    MAGEC1
    NDNL2    MAGEB10    MAGEB4    MAGEB5    MAGEC2    MAGEC4
    MAGEE1    MAGEA4    MAGEA10    MAGEA9B    MAGEB2    MAGEA11

    MAGEB16 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MAGEB16
    PGOHUM00000241674 PGOHUM00000241699


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/141 SNPs in MAGEB16 are shown (see all 141)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs736295591,2
    C,F--35814697(+) CATTAT/CTTTAT 1 -- us2k12Minor allele frequency- C:0.00WA CSA 3
    rs1885662741,2
    --35814700(+) TACTTA/TATTAT 1 -- us2k10--------
    rs98870631,2
    H--35815290(+) ACCAAC/GTGGTG 1 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs1813625051,2
    C--35815324(+) AGTAGA/GATTTC 1 -- us2k10--------
    rs1852493351,2
    --35815468(+) ATTGGA/GTATAC 1 -- us2k10--------
    rs1900381661,2
    --35815521(+) AAGAAA/CAAATT 1 -- us2k10--------
    rs1478957021,2
    --35815597(+) CATTGC/TACTAT 1 -- us2k10--------
    rs736295601,2
    C,F--35815685(+) AACCCT/AAGTGA 1 -- us2k11Minor allele frequency- A:0.00WA 2
    rs59734851,2
    C,F,A,H--35815718(+) TCTAAA/GGGAAT 1 -- us2k110Minor allele frequency- G:0.06NS EA NA WA CSA 543
    rs1870129061,2
    --35815944(+) GACCAA/GCCTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAGEB16 (35816459 - 35821852 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MAGEB16:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv24451CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300762    OMIM disorders: --

    2 diseases for MAGEB16:    About MalaCards
    melanoma    


    MAGEB16 for disorders           About GeneDecksing


    Export disorders for MAGEB16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGEB16 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MAGEB16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. An overview of the MAGE gene family with the identification of all human members of the family. (PubMed id 11454705)1, 3 Chomez P....Lucas S. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 139604 HGNC: 21188 Ensembl:ENSG00000189023 euGenes: HUgn139604 ECgene: MAGEB16
    H-InvDB: MAGEB16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAGEB16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEB16 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAGEB16 gene:
    Search GeneIP for patents involving MAGEB16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Search ThermoFisher Antibodies for MAGEB16
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAGEB16
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MAGEB16
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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