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Aliases for MAGEB10 Gene

Aliases for MAGEB10 Gene

  • MAGE Family Member B10 2 3 5
  • Melanoma Antigen Family B10 2
  • MAGE-B10 Antigen 4

External Ids for MAGEB10 Gene

Previous GeneCards Identifiers for MAGEB10 Gene

  • GC0XP027585
  • GC0XM027672
  • GC0XM027821
  • GC0XP027736
  • GC0XP025565

Summaries for MAGEB10 Gene

Entrez Gene Summary for MAGEB10 Gene

  • This gene encodes a member of the B subfamily of the melanoma associated antigen protein family. The encoded protein is specifically expressed in testis and tumor cells. [provided by RefSeq, Apr 2010]

GeneCards Summary for MAGEB10 Gene

MAGEB10 (MAGE Family Member B10) is a Protein Coding gene. An important paralog of this gene is MAGEC3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB10 Gene

Genomics for MAGEB10 Gene

Regulatory Elements for MAGEB10 Gene

Enhancers for MAGEB10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAGEB10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAGEB10 Gene

Chromosome:
X
Start:
27,807,450 bp from pter
End:
27,823,532 bp from pter
Size:
16,083 bases
Orientation:
Plus strand

Genomic View for MAGEB10 Gene

Genes around MAGEB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB10 Gene

Proteins for MAGEB10 Gene

  • Protein details for MAGEB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LZ2-MAGBA_HUMAN
    Recommended name:
    Melanoma-associated antigen B10
    Protein Accession:
    Q96LZ2
    Secondary Accessions:
    • Q494Y6
    • Q494Y7
    • Q9BZ78

    Protein attributes for MAGEB10 Gene

    Size:
    347 amino acids
    Molecular mass:
    38971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEB10 Gene

Proteomics data for MAGEB10 Gene at MOPED

Post-translational modifications for MAGEB10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MAGEB10 Gene

Domains & Families for MAGEB10 Gene

Gene Families for MAGEB10 Gene

Protein Domains for MAGEB10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEB10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LZ2

UniProtKB/Swiss-Prot:

MAGBA_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEB10: view

Function for MAGEB10 Gene

genes like me logo Genes that share phenotypes with MAGEB10: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEB10 Gene

Localization for MAGEB10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEB10 Gene COMPARTMENTS Subcellular localization image for MAGEB10 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEB10 Gene

Pathways & Interactions for MAGEB10 Gene

SuperPathways for MAGEB10 Gene

No Data Available

Interacting Proteins for MAGEB10 Gene

Gene Ontology (GO) - Biological Process for MAGEB10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEB10 Gene

Drugs & Compounds for MAGEB10 Gene

No Compound Related Data Available

Transcripts for MAGEB10 Gene

mRNA/cDNA for MAGEB10 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB10 Gene

Melanoma antigen family B, 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB10 Gene

No ASD Table

Relevant External Links for MAGEB10 Gene

GeneLoc Exon Structure for
MAGEB10
ECgene alternative splicing isoforms for
MAGEB10

Expression for MAGEB10 Gene

mRNA expression in normal human tissues for MAGEB10 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEB10 Gene

This gene is overexpressed in Testis (x50.6).

Protein differential expression in normal tissues from HIPED for MAGEB10 Gene

This gene is overexpressed in Platelet (44.4), Testis (13.4), and Fetal ovary (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEB10 Gene



SOURCE GeneReport for Unigene cluster for MAGEB10 Gene Hs.447363

genes like me logo Genes that share expression patterns with MAGEB10: view

Protein tissue co-expression partners for MAGEB10 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAGEB10 Gene

Orthologs for MAGEB10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB10 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia MAGEB10 35
  • 76.77 (n)
  • 65.48 (a)
MAGEB10 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAGEB10 35
  • 98.56 (n)
  • 96.54 (a)
MAGEB10 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAGEB10 36
  • 55 (a)
OneToOne
Species with no ortholog for MAGEB10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB10 Gene

ENSEMBL:
Gene Tree for MAGEB10 (if available)
TreeFam:
Gene Tree for MAGEB10 (if available)

Paralogs for MAGEB10 Gene

genes like me logo Genes that share paralogs with MAGEB10: view

Variants for MAGEB10 Gene

Sequence variations from dbSNP and Humsavar for MAGEB10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs12557898 - 27,821,500(+) ACTTC(A/G)GGAAG reference, missense
rs1368769 - 27,821,455(+) TGTTT(C/T)CCAGA reference, missense
rs747672749 -- 27,816,085(+) ACCTG(C/T)CTCAC intron-variant
rs747684284 -- 27,822,394(+) TGCAC(A/T)TTCTG utr-variant-3-prime
rs747767443 -- 27,812,594(+) GAGCA(C/T)GTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEB10 Gene

Variant ID Type Subtype PubMed ID
nsv526948 CNV Gain 19592680
nsv521729 CNV Gain 19592680
esv274034 CNV Insertion 20981092

Variation tolerance for MAGEB10 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEB10 Gene

HapMap Linkage Disequilibrium report
MAGEB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEB10 Gene

Disorders for MAGEB10 Gene

Relevant External Links for MAGEB10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEB10

No disorders were found for MAGEB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAGEB10 Gene

Publications for MAGEB10 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. An overview of the MAGE gene family with the identification of all human members of the family. (PMID: 11454705) Chomez P. … Lucas S. (Cancer Res. 2001) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MAGEB10 Gene

Sources for MAGEB10 Gene

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