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Aliases for MAGEB10 Gene

Aliases for MAGEB10 Gene

  • MAGE Family Member B10 2 3 5
  • Melanoma Antigen Family B10 2
  • MAGE-B10 Antigen 4

External Ids for MAGEB10 Gene

Previous GeneCards Identifiers for MAGEB10 Gene

  • GC0XP027585
  • GC0XM027672
  • GC0XM027821
  • GC0XP027736
  • GC0XP025565

Summaries for MAGEB10 Gene

Entrez Gene Summary for MAGEB10 Gene

  • This gene encodes a member of the B subfamily of the melanoma associated antigen protein family. The encoded protein is specifically expressed in testis and tumor cells. [provided by RefSeq, Apr 2010]

GeneCards Summary for MAGEB10 Gene

MAGEB10 (MAGE Family Member B10) is a Protein Coding gene. Diseases associated with MAGEB10 include Melanoma. An important paralog of this gene is MAGEB4.

Additional gene information for MAGEB10 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB10 Gene

Genomics for MAGEB10 Gene

Regulatory Elements for MAGEB10 Gene

Enhancers for MAGEB10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH027619 0.5 ENCODE 0.1 -187.8 -187759 1 CTCF JUN RAD21 DCAF8L2 MAGEB10
GH0XH027675 0.4 ENCODE 0.1 -131.8 -131772 0 NFIB CEBPB DCAF8L2 MAGEB10
GH0XH027597 0.4 ENCODE 0.1 -209.0 -209013 1 SOX5 SOX13 DCAF8L2 MAGEB10
GH0XH027600 0.4 ENCODE 0.1 -206.5 -206512 0 JUN DCAF8L2 MAGEB10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAGEB10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAGEB10 Gene

Chromosome:
X
Start:
27,807,450 bp from pter
End:
27,823,532 bp from pter
Size:
16,083 bases
Orientation:
Plus strand

Genomic View for MAGEB10 Gene

Genes around MAGEB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB10 Gene

Proteins for MAGEB10 Gene

  • Protein details for MAGEB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LZ2-MAGBA_HUMAN
    Recommended name:
    Melanoma-associated antigen B10
    Protein Accession:
    Q96LZ2
    Secondary Accessions:
    • Q494Y6
    • Q494Y7
    • Q9BZ78

    Protein attributes for MAGEB10 Gene

    Size:
    347 amino acids
    Molecular mass:
    38971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEB10 Gene

Post-translational modifications for MAGEB10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEB10 Gene

Domains & Families for MAGEB10 Gene

Gene Families for MAGEB10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEB10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEB10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEB10: view

No data available for UniProtKB/Swiss-Prot for MAGEB10 Gene

Function for MAGEB10 Gene

genes like me logo Genes that share phenotypes with MAGEB10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAGEB10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEB10 Gene

Localization for MAGEB10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEB10 gene
Compartment Confidence
mitochondrion 2
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MAGEB10 Gene

Pathways & Interactions for MAGEB10 Gene

SuperPathways for MAGEB10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEB10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEB10 Gene

Drugs & Compounds for MAGEB10 Gene

No Compound Related Data Available

Transcripts for MAGEB10 Gene

mRNA/cDNA for MAGEB10 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB10 Gene

Melanoma antigen family B, 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAGEB10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB10 Gene

No ASD Table

Relevant External Links for MAGEB10 Gene

GeneLoc Exon Structure for
MAGEB10
ECgene alternative splicing isoforms for
MAGEB10

Expression for MAGEB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEB10 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEB10 Gene

This gene is overexpressed in Testis (x50.6).

Protein differential expression in normal tissues from HIPED for MAGEB10 Gene

This gene is overexpressed in Platelet (44.4), Testis (13.4), and Fetal ovary (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEB10 Gene



Protein tissue co-expression partners for MAGEB10 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGEB10 Gene:

MAGEB10

SOURCE GeneReport for Unigene cluster for MAGEB10 Gene:

Hs.447363
genes like me logo Genes that share expression patterns with MAGEB10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEB10 Gene

Orthologs for MAGEB10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEB10 33 34
  • 98.56 (n)
dog
(Canis familiaris)
Mammalia MAGEB10 33 34
  • 76.77 (n)
cow
(Bos Taurus)
Mammalia MAGEB10 34
  • 55 (a)
OneToOne
Species where no ortholog for MAGEB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB10 Gene

ENSEMBL:
Gene Tree for MAGEB10 (if available)
TreeFam:
Gene Tree for MAGEB10 (if available)

Paralogs for MAGEB10 Gene

Variants for MAGEB10 Gene

Sequence variations from dbSNP and Humsavar for MAGEB10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000211395 -- 27,822,603(+) TATAA(A/G)TCTAA utr-variant-3-prime
rs1000322499 -- 27,822,932(+) ATGGC(A/G)TAAAC utr-variant-3-prime
rs1000387714 -- 27,814,865(+) CTGTC(-/TT)TTAAT intron-variant
rs1000878544 -- 27,812,667(+) GGGAA(A/G)TGCCC intron-variant
rs1001330618 -- 27,817,914(+) TCCAC(A/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEB10 Gene

Variant ID Type Subtype PubMed ID
esv3309762 CNV mobile element insertion 20981092
esv3336974 CNV insertion 20981092
esv3432532 CNV insertion 20981092
nsv521729 CNV gain 19592680
nsv526948 CNV gain 19592680

Variation tolerance for MAGEB10 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEB10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAGEB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEB10 Gene

Disorders for MAGEB10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEB10 Gene - From: GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEB10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEB10
genes like me logo Genes that share disorders with MAGEB10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEB10 Gene

Publications for MAGEB10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. An overview of the MAGE gene family with the identification of all human members of the family. (PMID: 11454705) Chomez P … Lucas S (Cancer research 2001) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 60

Products for MAGEB10 Gene

Sources for MAGEB10 Gene

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