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Aliases for MAGEB10 Gene

Aliases for MAGEB10 Gene

  • Melanoma Antigen Family B10 2 3
  • MAGE-B10 Antigen 4

External Ids for MAGEB10 Gene

Previous GeneCards Identifiers for MAGEB10 Gene

  • GC0XP027585
  • GC0XM027672
  • GC0XM027821
  • GC0XP027736
  • GC0XP025565

Summaries for MAGEB10 Gene

Entrez Gene Summary for MAGEB10 Gene

  • This gene encodes a member of the B subfamily of the melanoma associated antigen protein family. The encoded protein is specifically expressed in testis and tumor cells. [provided by RefSeq, Apr 2010]

GeneCards Summary for MAGEB10 Gene

MAGEB10 (Melanoma Antigen Family B10) is a Protein Coding gene. Diseases associated with MAGEB10 include melanoma. An important paralog of this gene is MAGED1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB10 Gene

Genomics for MAGEB10 Gene

Regulatory Elements for MAGEB10 Gene

Genomic Location for MAGEB10 Gene

Start:
27,807,990 bp from pter
End:
27,823,014 bp from pter
Size:
15,025 bases
Orientation:
Plus strand

Genomic View for MAGEB10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB10 Gene

Proteins for MAGEB10 Gene

  • Protein details for MAGEB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LZ2-MAGBA_HUMAN
    Recommended name:
    Melanoma-associated antigen B10
    Protein Accession:
    Q96LZ2
    Secondary Accessions:
    • Q494Y6
    • Q494Y7
    • Q9BZ78

    Protein attributes for MAGEB10 Gene

    Size:
    347 amino acids
    Molecular mass:
    38971 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEB10 Gene

Proteomics data for MAGEB10 Gene at MOPED

Post-translational modifications for MAGEB10 Gene

  • Ubiquitination at Lys287
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEB10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEB10 Gene

Domains for MAGEB10 Gene

Protein Domains for MAGEB10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEB10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LZ2

UniProtKB/Swiss-Prot:

MAGBA_HUMAN :
  • Q96LZ2
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEB10: view

No data available for Gene Families for MAGEB10 Gene

Function for MAGEB10 Gene

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEB10

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MAGEB10 Gene

Localization for MAGEB10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEB10 Gene COMPARTMENTS Subcellular localization image for MAGEB10 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEB10 Gene

Pathways for MAGEB10 Gene

SuperPathways for MAGEB10 Gene

No Data Available

Interacting Proteins for MAGEB10 Gene

Gene Ontology (GO) - Biological Process for MAGEB10 Gene

None

No data available for Pathways by source for MAGEB10 Gene

Transcripts for MAGEB10 Gene

mRNA/cDNA for MAGEB10 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEB10 Gene

Melanoma antigen family B, 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEB10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MAGEB10
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB10 Gene

No ASD Table

Relevant External Links for MAGEB10 Gene

GeneLoc Exon Structure for
MAGEB10
ECgene alternative splicing isoforms for
MAGEB10

Expression for MAGEB10 Gene

mRNA expression in normal human tissues for MAGEB10 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEB10 Gene

This gene is overexpressed in Testis (50.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAGEB10 Gene

SOURCE GeneReport for Unigene cluster for MAGEB10 Gene Hs.447363

genes like me logo Genes that share expressions with MAGEB10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAGEB10 Gene

Orthologs for MAGEB10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEB10 35
  • 98.56 (n)
  • 96.54 (a)
MAGEB10 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAGEB10 36
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAGEB10 35
  • 76.77 (n)
  • 65.48 (a)
MAGEB10 36
  • 63 (a)
OneToOne
Species with no ortholog for MAGEB10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB10 Gene

ENSEMBL:
Gene Tree for MAGEB10 (if available)
TreeFam:
Gene Tree for MAGEB10 (if available)

Paralogs for MAGEB10 Gene

genes like me logo Genes that share paralogs with MAGEB10: view

Variants for MAGEB10 Gene

Sequence variations from dbSNP and Humsavar for MAGEB10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs999577 -- 27,819,337(+) GCACT(A/G)GGTCC intron-variant
rs1368769 - 27,821,455(+) TGTTT(C/T)CCAGA missense, reference
rs4399068 -- 27,819,465(+) TTCCA(A/G)GTCCT intron-variant
rs4829084 -- 27,808,995(+) CCCTC(A/G)CTGGC intron-variant
rs4829085 -- 27,809,036(+) TTTGG(C/T)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEB10 Gene

Variant ID Type Subtype PubMed ID
nsv526948 CNV Gain 19592680
nsv521729 CNV Gain 19592680
esv274034 CNV Insertion 20981092

Relevant External Links for MAGEB10 Gene

HapMap Linkage Disequilibrium report
MAGEB10
Locus Specific Mutation Databases (LSDB)
MAGEB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEB10 Gene

Disorders for MAGEB10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MAGEB10 Gene including...

Search for MAGEB10 Gene in MalaCards »
genes like me logo Genes that share disorders with MAGEB10: view

No data available for UniProtKB/Swiss-Prot for MAGEB10 Gene

Publications for MAGEB10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. An overview of the MAGE gene family with the identification of all human members of the family. (PMID: 11454705) Chomez P. … Lucas S. (Cancer Res. 2001) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for MAGEB10 Gene

Sources for MAGEB10 Gene

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