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MAGEB10 Gene

protein-coding   GIFtS: 45
GCID: GC0XP027826

Melanoma Antigen Family B, 10

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Melanoma Antigen Family B, 101 2
MAGE-B10 Antigen2 3
MAGE Family Testis And Tumor-Specific Protein2
Melanoma-Associated Antigen B102

External Ids:    HGNC: 253771   Entrez Gene: 1394222   Ensembl: ENSG000001776897   OMIM: 3007615   UniProtKB: Q96LZ23   

Export aliases for MAGEB10 gene to outside databases

Previous GC identifers: GC0XP027585 GC0XM027672 GC0XM027821 GC0XP027736 GC0XP025565


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAGEB10 Gene:
This gene encodes a member of the B subfamily of the melanoma associated antigen protein family. The encoded
protein is specifically expressed in testis and tumor cells. (provided by RefSeq, Apr 2010)

GeneCards Summary for MAGEB10 Gene:
MAGEB10 (melanoma antigen family B, 10) is a protein-coding gene. Diseases associated with MAGEB10 include melanoma. An important paralog of this gene is MAGEC2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAGEB10 gene promoter:
         TBP   RFX1   Tal-1   ATF-2   MyoD   CUTL1   POU6F1 (c2)   E47   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGEB10 promoter sequence
   Search Chromatin IP Primers for MAGEB10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGEB10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.3   Ensembl cytogenetic band:  Xp21.3   HGNC cytogenetic band: Xp21.3

MAGEB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEB10 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP027826:  view genomic region     (about GC identifiers)

Start:
27,826,107 bp from pter      End:
27,841,131 bp from pter
Size:
15,025 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAGBA_HUMAN, Q96LZ2 (See protein sequence)
Recommended Name: Melanoma-associated antigen B10  
Size: 347 amino acids; 38971 Da
Secondary accessions: Q494Y6 Q494Y7 Q9BZ78

Explore the universe of human proteins at neXtProt for MAGEB10: NX_Q96LZ2

Explore proteomics data for MAGEB10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys287
  • Modification sites at PhosphoSitePlus

  • See MAGEB10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872312.2  
    ENSEMBL proteins: 
     ENSP00000368304  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry Q96LZ2

    ProtoNet protein and cluster: Q96LZ2

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGBA_HUMAN, Q96LZ2
    Similarity: Contains 1 MAGE domain


    MAGEB10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAGEB10
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytosol1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAGEB10
    Interactions:

        Search GeneGlobe Interaction Network for MAGEB10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for MAGEB10 (Q96LZ23 ENSP000003683044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    MAP3K4Q9Y6R43I2D: score=2 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAGEB10 (MAGBA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAGEB10 gene: 
    NM_182506.3  

    Unigene Cluster for MAGEB10:

    Melanoma antigen family B, 10
    Hs.447363  [show with all ESTs]
    Unigene Representative Sequence: NM_182506
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000356790(uc004dbw.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MAGEB10
      QuantiFast Probe-based Assays in human, mouse, rat MAGEB10

    Additional mRNA sequence: 

    AK057527.1 BC101307.2 BC101308.2 BC101309.3 BC101310.2 

    1 DOTS entry:

    DT.95217355 

    3 AceView cDNA sequences:

    AK057527 BV169219 NM_182506 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAGEB10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAAACCAG
    MAGEB10 Expression
    About this image

    MAGEB10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAGEB10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.447363
        Custom PCR Arrays for MAGEB10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for MAGEB10 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia MAGEB101 melanoma antigen family B, 10 76.77(n)
    65.48(a)
      403710  NM_001003116.1  NP_001003116.1 


    ENSEMBL Gene Tree for MAGEB10 (if available)
    TreeFam Gene Tree for MAGEB10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAGEB10 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEB42  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEA62  MAGED12  MAGEA22  
    MAGEA32  MAGEB22  NDN2  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  MAGEA102  
    MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  MAGEA112  NDNL22  MAGEF12  
    Selected SIMAP similar genes for MAGEB10 using alignment to 1 protein entry:     MAGBA_HUMAN(see all similar genes):
    MAGEC4    MAGEB4    MAGE-B1    MAGEB1    MAGEB16    MAGEB17
    MAGEB18    MAGEB5    MAGEB2    MAGEB3    MAGEC1    MAGEH1
    MAGEA8    MAGEC3    MAGEA9    MAGEA9B    MAGEC2    MAGEE1

    MAGEB10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAGEB10 (see all 223)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs66535561,2
    C,F--27739110(+) AGTGTG/TATCAG 1 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1917766091,2
    --27739263(+) TGATTA/CTGAGT 1 -- us2k10--------
    rs1838162171,2
    --27739358(+) CAAATG/TAAAAC 1 -- us2k10--------
    rs1879109001,2
    --27739430(+) ATTGCA/GAAACG 1 -- us2k10--------
    rs1512382191,2
    --27739432(+) TGCGAA/GACGCA 1 -- us2k10--------
    rs1404685991,2
    --27739580(+) ACTCAA/CTTTCC 1 -- us2k10--------
    rs2009318451,2
    --27739762(+) AATGG-/AAAAAA 1 -- us2k10--------
    rs675286721,2
    C,F--27739813(+) AAAAAT/ATTGCC 1 -- us2k12Minor allele frequency- A:0.25WA 4
    rs59265001,2
    C,A--27739957(+) TGGCTG/CAGACT 1 -- us2k15Minor allele frequency- C:0.12WA NA CSA 8
    rs1125924321,2
    C,F--27740074(+) TCATGG/TGTCAG 1 -- us2k11Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for MAGEB10 (27826107 - 27841131 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MAGEB10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274034CNV Insertion20981092
    nsv521729CNV Gain19592680
    nsv526948CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): MAGEB10

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MAGEB10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300761    OMIM disorders: --

    1 disease for MAGEB10:    
    About MalaCards
    melanoma


    MAGEB10 for disorders           About GeneDecksing


    Export disorders for MAGEB10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAGEB10 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MAGEB10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. An overview of the MAGE gene family with the identification of all human members of the family. (PubMed id 11454705)1, 3 Chomez P.... Lucas S. (Cancer Res. 2001)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 139422 HGNC: 25377 AceView: MAGEB10 Ensembl:ENSG00000177689 euGenes: HUgn139422
    ECgene: MAGEB10 H-InvDB: MAGEB10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAGEB10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEB10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAGEB10 gene:
    Search GeneIP for patents involving MAGEB10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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