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Aliases for MAGEB1 Gene

Aliases for MAGEB1 Gene

  • MAGE Family Member B1 2 3 5
  • DSS/AHC Critical Interval MAGE Superfamily 10 2 3
  • DSS-AHC Critical Interval MAGE Superfamily 10 3 4
  • Melanoma Antigen Family B1 2 3
  • Cancer/Testis Antigen 3.1 3 4
  • MAGE-B1 Antigen 3 4
  • MAGE-XP Antigen 3 4
  • MAGEL1 3 4
  • CT3.1 3 4
  • DAM10 3 4
  • Cancer/Testis Antigen Family 3, Member 1 3
  • Cancer/Testis Antigen Family 3 2
  • Melanoma Antigen Family B, 1 3
  • Member 1 2
  • MAGE-Xp 3
  • MAGEXP 4

External Ids for MAGEB1 Gene

Previous GeneCards Identifiers for MAGEB1 Gene

  • GC0XP028761
  • GC0XP028944
  • GC0XP029463
  • GC0XP029623
  • GC0XP030021
  • GC0XP030170
  • GC0XP027998

Summaries for MAGEB1 Gene

Entrez Gene Summary for MAGEB1 Gene

  • This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region, and expressed in testis and in a significant fraction of tumors of various histological types. This gene and other MAGEB members are clustered on chromosome Xp22-p21. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene, however, the full length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEB1 Gene

MAGEB1 (MAGE Family Member B1) is a Protein Coding gene. Diseases associated with MAGEB1 include melanoma and alternating hemiplegia of childhood. An important paralog of this gene is MAGEC3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEB1 Gene

Genomics for MAGEB1 Gene

Regulatory Elements for MAGEB1 Gene

Genomic Location for MAGEB1 Gene

Chromosome:
X
Start:
30,243,730 bp from pter
End:
30,252,038 bp from pter
Size:
8,309 bases
Orientation:
Plus strand

Genomic View for MAGEB1 Gene

Genes around MAGEB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEB1 Gene

Proteins for MAGEB1 Gene

  • Protein details for MAGEB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43366-MAGB1_HUMAN
    Recommended name:
    Melanoma-associated antigen B1
    Protein Accession:
    P43366
    Secondary Accessions:
    • B2RC79
    • O00601
    • O75862
    • Q6FHJ0
    • Q96CW8

    Protein attributes for MAGEB1 Gene

    Size:
    347 amino acids
    Molecular mass:
    39037 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEB1 Gene

Proteomics data for MAGEB1 Gene at MOPED

Post-translational modifications for MAGEB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEB1 Gene

No data available for DME Specific Peptides for MAGEB1 Gene

Domains & Families for MAGEB1 Gene

Gene Families for MAGEB1 Gene

Protein Domains for MAGEB1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43366

UniProtKB/Swiss-Prot:

MAGB1_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEB1: view

Function for MAGEB1 Gene

Molecular function for MAGEB1 Gene

GENATLAS Biochemistry:
melanoma antigen,family B,member 1,with two alternatively spliced isoforms,expressed in testis,melanoma and lung carcinomas

Phenotypes for MAGEB1 Gene

genes like me logo Genes that share phenotypes with MAGEB1: view

Animal Model Products

miRNA for MAGEB1 Gene

miRTarBase miRNAs that target MAGEB1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEB1 Gene

Localization for MAGEB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEB1 Gene COMPARTMENTS Subcellular localization image for MAGEB1 gene
Compartment Confidence
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEB1 Gene

Pathways & Interactions for MAGEB1 Gene

SuperPathways for MAGEB1 Gene

No Data Available

Interacting Proteins for MAGEB1 Gene

Gene Ontology (GO) - Biological Process for MAGEB1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEB1 Gene

Drugs & Compounds for MAGEB1 Gene

No Compound Related Data Available

Transcripts for MAGEB1 Gene

mRNA/cDNA for MAGEB1 Gene

Unigene Clusters for MAGEB1 Gene

Melanoma antigen family B, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEB1 Gene

No ASD Table

Relevant External Links for MAGEB1 Gene

GeneLoc Exon Structure for
MAGEB1
ECgene alternative splicing isoforms for
MAGEB1

Expression for MAGEB1 Gene

mRNA expression in normal human tissues for MAGEB1 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEB1 Gene

This gene is overexpressed in Testis (x52.0).

Protein differential expression in normal tissues from HIPED for MAGEB1 Gene

This gene is overexpressed in Testis (35.3) and Ovary (27.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEB1 Gene



SOURCE GeneReport for Unigene cluster for MAGEB1 Gene Hs.73021

mRNA Expression by UniProt/SwissProt for MAGEB1 Gene

P43366-MAGB1_HUMAN
Tissue specificity: Expressed only in testis.
genes like me logo Genes that share expression patterns with MAGEB1: view

Protein tissue co-expression partners for MAGEB1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGEB1 Gene

Orthologs for MAGEB1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEB1 35
  • 99.04 (n)
  • 98.27 (a)
MAGEB1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 56 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
MAGEB4 36
  • 47 (a)
ManyToMany
MGC133764 36
  • 44 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
ManyToMany
LOC491795 35
  • 68.82 (n)
  • 57.77 (a)
mouse
(Mus musculus)
Mammalia Mageb3 35
  • 65.33 (n)
  • 53.67 (a)
Mageb4 36
  • 32 (a)
OneToMany
Mageb3 16
Species with no ortholog for MAGEB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEB1 Gene

ENSEMBL:
Gene Tree for MAGEB1 (if available)
TreeFam:
Gene Tree for MAGEB1 (if available)

Paralogs for MAGEB1 Gene

genes like me logo Genes that share paralogs with MAGEB1: view

Variants for MAGEB1 Gene

Sequence variations from dbSNP and Humsavar for MAGEB1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs7062640 - 30,251,292(+) CCCCA(A/C/T)GCTAT reference, missense
rs2074794 -- 30,247,438(+) TCAGC(C/G)GAGGG intron-variant, utr-variant-5-prime
rs2529566 -- 30,248,261(+) TTCAT(A/G)GTCTT intron-variant
rs2529567 -- 30,250,576(+) GGTTG(C/G)TCACG reference, missense
rs6631062 -- 30,247,701(+) gaact(C/T)tggga intron-variant

Variation tolerance for MAGEB1 Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEB1 Gene

HapMap Linkage Disequilibrium report
MAGEB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAGEB1 Gene

Disorders for MAGEB1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAGEB1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
alternating hemiplegia of childhood
  • ahc
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEB1

Genetic Association Database (GAD)
MAGEB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEB1
genes like me logo Genes that share disorders with MAGEB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEB1 Gene

Publications for MAGEB1 Gene

  1. Isolation and characterization of a MAGE gene family in the Xp21.3 region. (PMID: 7761436) Muscatelli F. … Monaco A.P. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 67
  2. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PMID: 9441743) Lurquin C. … Boon T. (Genomics 1997) 2 3 23
  3. A family of rapidly evolving genes from the sex reversal critical region in Xp21. (PMID: 8535061) Dabovic B. … Camerino G. (Mamm. Genome 1995) 3 23
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. (PMID: 21364888) Hudson J.J. … Palecek J. (PLoS ONE 2011) 3

Products for MAGEB1 Gene

Sources for MAGEB1 Gene

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