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MAGEB1 Gene

protein-coding   GIFtS: 51

GC0XP030170
melanoma antigen family B, 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for MAGEB1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CT3.1 1, 2, 3
DAM10 1, 2, 3, 5
MAGE-Xp 1, 2
MAGEL1 1, 2, 3, 5
MAGEXP 3
MGC9322 1, 2
OTTHUMP00000023101 2
Descriptions
Cancer/testis antigen 3.1 3
DSS-AHC critical interval MAGE superfamily 10 3
DSS/AHC critical interval MAGE superfamily 10 2
MAGE-B1 antigen 3
MAGE-XP antigen 3
cancer/testis antigen family 3, member 1 2
melanoma antigen family B, 1 2
External Ids
HGNC: 68081
Entrez Gene: 41122
UniProtKB: P433663
Ensembl: ENSG000002141077
Search outside databases for aliases for MAGEB1 gene

Previous GC identifers: GC0XP028761 GC0XP028944 GC0XP029463 GC0XP029623 GC0XP030021

Summaries
for MAGEB1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for MAGEB1:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding
sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to
each other. The promoters and first exons of the MAGEB genes show considerable variability,
suggesting that the existence of this gene family enables the same function to be expressed under
different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex
reversal) critical region, and expressed in testis and in a significant fraction of tumors of
various histological types. This gene and other MAGEB members are clustered on chromosome
Xp22-p21. Multiple alternatively spliced transcript variants encoding the same protein have been
found for this gene, however, the full length nature of some variants has not been defined.
[provided by RefSeq]

Genomic Location
for MAGEB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MAGEB1 gene  

Entrez Gene cytogenetic band: Xp21.3   Ensembl cytogenetic band:  Xp21.2   HGNC cytogenetic band: Xp21.3

MAGEB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP030170:     (about GC identifiers)

Start:
 30,171,769 bp from pter
End:
 30,180,076 bp from pter
Size:
 8,308 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000023.9  NT_011757.15  

Proteins
for MAGEB1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: MAGB1_HUMAN, P43366 (See protein sequence)
Recommended Name: Melanoma-associated antigen B1  
Size: 347 amino acids; 39037 Da
Secondary accessions: O00601 O75862 Q6FHJ0 Q96CW8

REFSEQ proteins (3 alternative transcripts): 
NP_002354.2  NP_796379.1  NP_803134.1  


ENSEMBL proteins: 
ENSP00000380683 ENSP00000368264 ENSP00000380681 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (MAGEB1)
Human Recombinant Proteins from Abnova (MAGEB1)
              OriGene Purified Recombinant Human Protein: MAGEB1 

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IDA18029348
GO:0005730 nucleolus IDA18029348
GO:0005737 cytoplasm IDA18029348
GO:0005794 Golgi apparatus IDA18029348
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Antibodies for MAGEB1: 
Browse Antibodies Central at Invitrogen
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Sigma-Aldrich Antibodies for MAGEB1
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Antibodies from Abcam (MAGEB1), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (MAGEB1)
Novus Biologicals Antibodies for MAGEB1

Assays for MAGEB1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for MAGEB1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR002190 MAGE


   GeneDecks  MAGEB1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P43366

ProtoNet protein and cluster: P43366

1 Blocks protein family: IPB002190 MAGE protein

UniProtKB/Swiss-Prot: MAGB1_HUMAN, P43366
Similarity: Contains 1 MAGE domain

Gene Function
for MAGEB1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (MAGEB1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002363

              Applied Biosystems Silencer® siRNAs for MAGEB1

              Sigma-Aldrich siRNA for MAGEB1  
                     Sigma-Aldrich shRNA for MAGEB1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002363
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002363
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002363 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_002363

Genatlas biochemistry entry for MAGEB1:
melanoma antigen,family B,member 1,with two alternatively spliced isoforms,expressed in
testis,melanoma and lung carcinomas

Pathways & Interactions
for MAGEB1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



1 Interacting protein for MAGEB1 (ENSP000003682643) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
NR0B1ENSP000003682533STRING (score=.775)
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Drugs & Compounds
for MAGEB1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGEB1

Transcripts
for MAGEB1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (MAGEB1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002363

              Sigma-Aldrich siRNA for MAGEB1  
                     Sigma-Aldrich shRNA for MAGEB1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_002363  NM_177404  NM_177415  

REFSEQ mRNAs for MAGEB1 gene (3 alternative transcripts): 

NM_002363.3   NM_177404.1   NM_177415.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_002363  NM_177404  NM_177415  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002363
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002363
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002363 

Additional cDNA sequence: 

AK314977.1 BC013772.1 CR541762.1 X82539.1 

3 DOTS entries:

DT.207292  DT.95163781  DT.100738208 

24 AceView cDNA sequences:

CR541762 BU189320 NM_177404 NM_002367 BU166425 NM_177415 BQ428314 BE897525 
BC013772 BF979409 BI826827 BI831285 X82539 CR541779 BX105170 BC032852 
NM_002363 BI460724 AA634391 AA412095 BG493595 BG719131 BF980356 BQ216792 

highest scoring ESTs for MAGEB1:

X82539 AA412095 BC013772 BX105170 BE897525 BG493595 BI826827 BQ428314 BU166425 BU189320 

Unigene Cluster for MAGEB1:

Melanoma antigen family B, 1
Hs.73021  [show with all ESTs]
Unigene Representative Sequence: X82539


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000397550  ENST00000378981  ENST00000397548  

Expression
for MAGEB1

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAGEB1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for MAGEB1

1 / 2 / 3

3 probe-sets matching MAGEB1 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

33970_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X82539 1.00 0.90 0.95 1

207534_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002363 0.60 1.00 0.82 1

207534_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TCAAGTTTTT

SOURCE GeneReport for Unigene cluster: Hs.73021

Expression variation in blood from EXPOLDB for MAGEB1

UniProtKB/Swiss-Prot: MAGB1_HUMAN, P43366
Tissue specificity: Expressed only in testis

Orthologs
for MAGEB1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for MAGEB1 gene from 5 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 MAGEB11   -- melanoma antigen family B, 1 76.19(n)
62.39(a)		 491802  XM_548921.1  XP_548921.1 
chimpanzee
(Pan troglodytes)		 MAGEB11   -- melanoma antigen family B, 1 99.03(n)
98.26(a)		 473549  XM_528921.2  XP_528921.1 
cow
(Bos taurus)		 MAGEB41   -- melanoma antigen family B, 4 71.92(n)
56.55(a)		 510437  XM_587577.3  XP_587577.2 
rat
(Rattus norvegicus)		 RGD15609041   -- similar to melanoma antigen family B, 2 71.47(n)
54.23(a)		 302744  XM_229036.3  XP_229036.3 
mouse
(Mus musculus)		 CN7168931   -- expressed sequence CN716893 71.47(n)
55.17(a)		 434903  NM_001033492.2  NP_001028664.2 
About this table        Species with no ortholog for MAGEB1

ENSEMBL Gene Tree for MAGEB1

Paralogs
for MAGEB1

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for MAGEB1 gene
MAGEB172  MAGEB62  MAGEB42  MAGEB22  

SNPs/Variants
for MAGEB1

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/30 NCBI SNPs in MAGEB1 are shown (see all 30 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 52)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs20747941,2
A,C,F,H,O30175476(+) TCAGCC/GGAGGG 3 -- int1 ut5111Minor allele frequency- G:0.20EU EA WA NA 745
rs25295691,2
C,F,H30179808(+) GCATAA/TGAGTT 3 -- ut314Minor allele frequency- T:0.01EU EA WA 416
--
rs70626401,2
C,F,H30179330(+) CCCCAC/TGCTAT 3 R/C mis15Minor allele frequency- T:0.01EU EA WA NA 468
--
rs172828441,2
F,H30175134(+) GAAGCG/CTACCA 3 -- int1 ng517Minor allele frequency- C:0.10NA EU EA WA 508
--
rs120116741,2
A,C30175155(+) CAGCCA/CGGAGG 3 -- int1 ng510--------
rs169889321,2
F,H30180346(+) TGTTAA/TTTTCC 3 -- ng317Minor allele frequency- T:0.02NA EU EA WA 528
--
rs25295671,2
H30178614(+) GGTTGC/GTCACG 3 A/G mis14Minor allele frequency- G:0.00EU EA WA 402
rs25295681,2
H30179045(+) CTAGTG/AGCCAC 3 S/G mis14Minor allele frequency- A:0.00EU EA WA 418
rs9503531,2
A,C,F,H,O30173133(+) AAAGGC/TCAGAG 2 -- int115Minor allele frequency- T:0.19NA EA NS EU WA 1022
rs25295661,2
C,F,H,O30176299(+) TTCATA/GGTCTT 3 -- int111Minor allele frequency- G:0.41EU EA WA NA 770
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HapMap Linkage Disequilibrium images for MAGEB1 (up to first 250kb)

Disorders & Mutations
for MAGEB1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 300097

Medical News
for MAGEB1

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for MAGEB1

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

8 PubMed articles for MAGEB1 gene:

Search for MAGEB1

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing MAGEB1

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 4112 HGNC: 6808 AceView: MAGEB1 Ensembl:ENSG00000214107 euGenes: HUgn4112
ECgene: MAGEB1 H-InvDB: MAGEB1

Other Databases showing MAGEB1

(According to HUGE)
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   --

Specialized Databases showing MAGEB1

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
ATLAS Chromosomes in Cancer entry for MAGEB1 Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies
for MAGEB1

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for MAGEB1

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for MAGEB1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Recombinant Proteins
(MAGEB1)
 Antibodies (MAGEB1)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for MAGEB1




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for MAGEB1

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