MAGEB1 Gene
protein-coding GIFtS: 48
GCID: GC0XP030261
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melanoma antigen family B, 1
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Aliases
for MAGEB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family B, 11 2 | | MAGE-B1 Antigen2 3 | | DAM101 2 3 5 | | MAGE-XP Antigen2 3 | | MAGEL11 2 3 5 | | MGC93221 | | CT3.11 2 3 | | Cancer/Testis Antigen Family 3, Member 12 | | MAGE-Xp1 2 | | DSS/AHC Critical Interval MAGE Superfamily 102 | | Cancer/Testis Antigen 3.12 3 | | Melanoma-Associated Antigen B12 | | DSS-AHC Critical Interval MAGE Superfamily 102 3 | | MAGEXP3 |
Export aliases for MAGEB1 gene to outside databasesPrevious GC identifers: GC0XP028761 GC0XP028944 GC0XP029463 GC0XP029623 GC0XP030021 GC0XP030170 GC0XP027998 |
Summaries
for MAGEB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEB1:
This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences locatedin the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and firstexons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables thesame function to be expressed under different transcriptional controls. This gene is localized in the DSS(dosage-sensitive sex reversal) critical region, and expressed in testis and in a significant fraction of tumors ofvarious histological types. This gene and other MAGEB members are clustered on chromosome Xp22-p21. Multiplealternatively spliced transcript variants encoding the same protein have been found for this gene, however, the fulllength nature of some variants has not been defined. (provided by RefSeq, Jul 2008)
|
Genomic Views
for MAGEB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEB1 gene promoter:
ARP-1 RelA NF-kappaB1 NF-kappaB
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp21.3 Ensembl cytogenetic band: Xp21.2 HGNC cytogenetic band: Xp21.3MAGEB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP030261: view genomic region
(about GC identifiers)
Start:
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30,261,847 bp from pter |
End:
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30,270,155 bp from pter |
Size:
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8,309 bases |
Orientation:
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plus strand |
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Proteins
for MAGEB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGB1_HUMAN, P43366 (See
protein sequence)Recommended Name: Melanoma-associated antigen B1 Size: 347 amino acids; 39037 Da
Secondary accessions: B2RC79 O00601 O75862 Q6FHJ0 Q96CW8Explore the universe of human proteins at neXtProt for MAGEB1: NX_P43366
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P43366
MAGEB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_002354.2 NP_796379.1 NP_803134.1
ENSEMBL proteins: ENSP00000368264 ENSP00000380683 ENSP00000380681
Human Recombinant Protein Products:
MAGEB1 Antibody Products:
Assay Products for MAGEB1: |
Protein
Domains /
Families
for MAGEB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEB1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P43366ProtoNet protein and cluster: P43366 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGB1_HUMAN, P43366Similarity: Contains 1 MAGE domain |
Function
for MAGEB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for MAGEB1:melanoma antigen,family B,member 1,with two alternatively spliced isoforms,expressed in testis,melanoma and lungcarcinomas
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB1 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB1 |
|
Pathways & Interactions
for MAGEB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEB1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for MAGEB1 (ENSP000003682644) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for MAGEB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEB1
Search CenterWatch for drugs/clinical trials and news about MAGEB1 / MAGB1
|
Transcripts
for MAGEB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEB1 gene (3 alternative transcripts): NM_002363.4 NM_177404.2 NM_177415.2 Unigene Cluster for MAGEB1: Melanoma antigen family B, 1 Hs.73021 [show with all ESTs]Unigene Representative Sequence: X825393 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378981(uc004dcc.3) ENST00000397550(uc004dcd.3) ENST00000397548(uc004dce.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEB1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MAGEB1 (NM_177404) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEB1 |
Additional cDNA sequence: AK314977.1 BC013772.1 CR541762.1 X82539.1 3 DOTS entries: DT.207292 DT.95163781 DT.100738208 24 AceView cDNA sequences: BU189320 NM_177404 BU166425 NM_177415 CR541762 NM_002367 BQ428314 BI460724 BE897525 BI826827 BI831285 BC013772 BC032852 X82539 AA634391 BF979409 CR541779 NM_002363 BX105170 BG719131 AA412095 BG493595 BF980356 BQ216792
GeneLoc Exon Structure
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Expression
for MAGEB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAAGTTTTT
About this image
See MAGEB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEB1
SOURCE GeneReport for Unigene cluster: Hs.73021
UniProtKB/Swiss-Prot: MAGB1_HUMAN, P43366Tissue specificity: Expressed only in testis
SABiosciences Custom PCR Arrays for MAGEB1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MAGEB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB1 |
Orthologs
for MAGEB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEB1 gene from 3/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
34(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
29(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
24(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEB1 (if available)
TreeFam Gene Tree for MAGEB1 (if available) |
Paralogs
for MAGEB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEB1 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEC12 MAGED42 MAGEA82
- MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12 MAGED12
- MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2 MAGEE22
- MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/38 SIMAP similar genes for MAGEB1 using alignment to 1 protein entry: MAGB1_HUMAN(see all similar genes):MAGE-B1 MAGEB2 MAGEB4 MAGEB17 MAGEB18 MAGEH1
MAGEB16 MAGEB3 MAGEB6 MAGEB10 MAGEC2 MAGEC4
MAGEC1 MAGEA8 MAGEB5 MAGEA9 MAGEA9B NDNL2
MAGEB1 for paralogs About GeneDecksing
|
Genomic Variants
for MAGEB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEB1 (30261847 - 30270155 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAGEB1
1 CNV: 3265
Locus Specific Mutation Databases (LSDB): MAGEB1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEB1 |
|
Disorders
/ Diseases
for MAGEB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEB1 for disorders About GeneDecksing
OMIM gene information: 300097
OMIM disorders: --
5  diseases for MAGEB1: About MalaCardsdosage-sensitive sex reversal sex reversal melanoma lung carcinoma
carcinoma
Export disorders for MAGEB1 gene to outside databases
|
Publications
for MAGEB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEB1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with MAGEB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterization of a MAGE gene family in the Xp21.3 region. (PubMed id 7761436)1, 2, 3 Muscatelli F.... Monaco A.P. (1995)
- Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. (PubMed id 9441743)1, 3, 9 Lurquin C.... Boon T. (1997)
- A family of rapidly evolving genes from the sex reversal critical region in Xp21. (PubMed id 8535061)1, 2, 9 Dabovic B.... Camerino G. (1995)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
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External Searches for MAGEB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEB1 gene:
Search GeneIP for patents involving MAGEB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | MAGEB1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEB1 |
|  |  |  | | | | ThermoFisher Antibodies for MAGEB1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEB1 |
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