MAGEA9B Gene
protein-coding GIFtS: 39
GCID: GC0XM148663
|
|
melanoma antigen family A, 9B
| |
Aliases
for MAGEA9B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family A, 9B1 2 | | Melanoma-Associated Antigen 92 | | Cancer/Testis Antigen 1.92 3 | | MAGE93 | | CT1.92 3 | | MAGEA9A3 | | MAGE-9 Antigen2 3 | | |
Export aliases for MAGEA9B gene to outside databasesPrevious GC identifers: GC0XM148471 GC00U922286 |
Summaries
for MAGEA9B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEA9B:
MAGEA9B is a duplication of the MAGEA9 gene (MIM 300342) on chromosome Xq28. The 2 copies are separated by about 194 kb(Hartz, 2009).(supplied by OMIM, Mar 2009)
UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumorprogression
|
Genomic Views
for MAGEA9B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011681.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEA9B gene promoter:
Nkx3-1 GR Pbx1a SREBP-1c GR-beta LCR-F1 HNF-3beta SREBP-1b SREBP-1a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEA9B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA9B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xp11MAGEA9B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM148663: view genomic region
(about GC identifiers)
Start:
|
148,663,309 bp from pter |
End:
|
148,669,116 bp from pter |
Size:
|
5,808 bases |
Orientation:
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minus strand |
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Proteins
for MAGEA9B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362 (See
protein sequence)Recommended Name: Melanoma-associated antigen 9 Size: 315 amino acids; 35088 Da
Secondary accessions: A8K8A7 Q7Z5K4 Q92910Explore the universe of human proteins at neXtProt for MAGEA9B: NX_P43362
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P43362
MAGEA9B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001074259.1
ENSEMBL proteins: ENSP00000243314
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
MAGEA9B for ontologies About GeneDecksing
MAGEA9B Antibody Products:
Assay Products for MAGEA9B: |
Protein
Domains /
Families
for MAGEA9B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEA9B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P43362ProtoNet protein and cluster: P43362 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362Similarity: Contains 1 MAGE domain |
Function
for MAGEA9B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumorprogression
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA9B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA9B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA9B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
MAGEA9B for ontologies About GeneDecksing
|
Pathways & Interactions
for MAGEA9B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEA9B
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
MAGEA9B for ontologies About GeneDecksing
|
Drugs & Compounds
for MAGEA9B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEA9B
Search CenterWatch for drugs/clinical trials and news about MAGEA9B / MAGA9
|
Transcripts
for MAGEA9B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEA9B gene: NM_001080790.1 Unigene Clusters for MAGEA9B: Melanoma antigen family A, 9B Hs.460974 [show with all ESTs], Hs.512582 [show with all ESTs]Unigene Representative Sequences: NM_001080790, NM_0053651 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000243314(uc004fdk.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA9B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA9B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAGEA9B (NM_001080790) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEA9B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAGEA9B |
Additional cDNA sequence: AK292272.1 AK313321.1 AY310325.1 BC002351.2 BC098100.1 5 DOTS entries: DT.92418006 DT.121317502 DT.100735256 DT.95328000 DT.100768078
GeneLoc Exon Structure
|
Expression
for MAGEA9B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEA9B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MAGEA9B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEA9B
SOURCE GeneReport for Unigene clusters: Hs.460974 Hs.512582
UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma,lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta
SABiosciences Custom PCR Arrays for MAGEA9B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEA9B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MAGEA9B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEA9B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEA9B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA9B |
Orthologs
for MAGEA9B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEA9B gene from 3/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
37(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
25(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
19(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEA9B (if available)
TreeFam Gene Tree for MAGEA9B (if available) |
Paralogs
for MAGEA9B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEA9B gene
- MAGEA91 2 MAGEC22 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGEA82 MAGED22 MAGEA122 MAGEB172 MAGEB102 MAGEA62 MAGEE12 MAGED12
- MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2 MAGEE22
- MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/37 SIMAP similar genes for MAGEA9B using alignment to 1 protein entry: MAGA9_HUMAN(see all similar genes):MAGEA9 MAGEA8 MAGEC4 MAGEA4 MAGEA12 MAGEA11
MAGEA1 MAGEA2 MAGEA6 MAGEA2B MAGEA3 MAGEA10
MAGEA5 MAGEB16 MAGEC1 MAGE-B1 MAGEB1 MAGEB17
MAGEA9B for paralogs About GeneDecksing
|
Genomic Variants
for MAGEA9B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEA9B (148663309 - 148669116 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MAGEA9B
3 CNVs: 4177 83832 9355 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEA9B |
|
Disorders
/ Diseases
for MAGEA9B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEA9B for disorders About GeneDecksing
OMIM gene information: 300764
OMIM disorders: --
8  diseases for MAGEA9B: About MalaCardsterminal osseous dysplasia osseous dysplasia melanoma enophthalmos
squamous cell carcinoma lung carcinoma breast carcinoma carcinoma
1 disease from the University of Copenhagen DISEASES database for MAGEA9B:Enophthalmos Export disorders for MAGEA9B gene to outside databases
|
Publications
for MAGEA9B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEA9B gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAGEA9B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Molecular and phenotypic variation in patients with severe Hunter syndrome. (PubMed id 9147653)1, 2 Timms K.M.... Gibbs R.A. (1997)
- Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (1994)
- Terminal osseous dysplasia is caused by a single recu rrent mutation in the FLNA gene. (PubMed id 20598277)2 Sun Y....Breuning M.H. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1 Rogner U.C....Poustka A. (1995)
|
External Searches for MAGEA9B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEA9B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEA9B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEA9B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAGEA9B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MAGEA9B gene:
Search GeneIP for patents involving MAGEA9B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEA9B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | Search Tocris compounds for MAGEA9B |
| |  |  |  |  | | | | |
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 | | | MAGEA9B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA9B |
|  |  |  | | | | Search ThermoFisher Antibodies for MAGEA9B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAGEA9B |
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