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Aliases for MAGEA9 Gene

Aliases for MAGEA9 Gene

  • Melanoma Antigen Family A9 2 3
  • MAGE-9 Antigen 2 3 4
  • MAGE9 3 4 6
  • Melanoma-Associated Antigen 9 2 3
  • Cancer/Testis Antigen 1.9 3 4
  • CT1.9 3 4
  • Cancer/Testis Antigen Family 1, Member 9 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma Antigen Family A, 9 3
  • MAGEA9 MAGEA9B 4
  • Member 9 2
  • MAGEA9A 4

External Ids for MAGEA9 Gene

Previous HGNC Symbols for MAGEA9 Gene

  • MAGE9

Previous GeneCards Identifiers for MAGEA9 Gene

  • GC0XP143533
  • GC0XP145914
  • GC0XP146754
  • GC0XP147569
  • GC0XP148569
  • GC0XP148671
  • GC0XP148863
  • GC0XM137617

Summaries for MAGEA9 Gene

Entrez Gene Summary for MAGEA9 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA9 Gene

MAGEA9 (Melanoma Antigen Family A9) is a Protein Coding gene. Diseases associated with MAGEA9 include terminal osseous dysplasia and enophthalmos. An important paralog of this gene is MAGED1.

UniProtKB/Swiss-Prot for MAGEA9 Gene

  • Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression

Gene Wiki entry for MAGEA9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA9 Gene

Genomics for MAGEA9 Gene

Regulatory Elements for MAGEA9 Gene

Genomic Location for MAGEA9 Gene

Start:
149,781,921 bp from pter
End:
149,787,739 bp from pter
Size:
5,819 bases
Orientation:
Plus strand

Genomic View for MAGEA9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA9 Gene

Proteins for MAGEA9 Gene

  • Protein details for MAGEA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43362-MAGA9_HUMAN
    Recommended name:
    Melanoma-associated antigen 9
    Protein Accession:
    P43362
    Secondary Accessions:
    • A8K8A7
    • Q7Z5K4
    • Q92910

    Protein attributes for MAGEA9 Gene

    Size:
    315 amino acids
    Molecular mass:
    35088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEA9 Gene

Proteomics data for MAGEA9 Gene at MOPED

Post-translational modifications for MAGEA9 Gene

  • Ubiquitination at Lys243
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEA9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEA9 Gene

Domains for MAGEA9 Gene

Protein Domains for MAGEA9 Gene

Graphical View of Domain Structure for InterPro Entry

P43362

UniProtKB/Swiss-Prot:

MAGA9_HUMAN :
  • P43362
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEA9: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MAGEA9 Gene

Function for MAGEA9 Gene

Molecular function for MAGEA9 Gene

GENATLAS Biochemistry: human melanoma antigen,family A,member 9,expressed in melanoma,testis
UniProtKB/Swiss-Prot Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression

Gene Ontology (GO) - Molecular Function for MAGEA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEA9: view

Phenotypes for MAGEA9 Gene

GenomeRNAi human phenotypes for MAGEA9:
genes like me logo Genes that share phenotypes with MAGEA9: view

Animal Model Products

CRISPR Products

miRNA for MAGEA9 Gene

miRTarBase miRNAs that target MAGEA9

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAGEA9 Gene

Localization for MAGEA9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEA9 Gene COMPARTMENTS Subcellular localization image for MAGEA9 gene
Compartment Confidence
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAGEA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAGEA9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAGEA9 Gene

Pathways for MAGEA9 Gene

SuperPathways for MAGEA9 Gene

No Data Available

Interacting Proteins for MAGEA9 Gene

Gene Ontology (GO) - Biological Process for MAGEA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEA9: view

No data available for Pathways by source for MAGEA9 Gene

Transcripts for MAGEA9 Gene

mRNA/cDNA for MAGEA9 Gene

(15) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEA9 Gene

Melanoma antigen family A, 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEA9

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA9 Gene

No ASD Table

Relevant External Links for MAGEA9 Gene

GeneLoc Exon Structure for
MAGEA9
ECgene alternative splicing isoforms for
MAGEA9

Expression for MAGEA9 Gene

mRNA expression in normal human tissues for MAGEA9 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEA9 Gene

This gene is overexpressed in Testis (53.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEA9 Gene

SOURCE GeneReport for Unigene cluster for MAGEA9 Gene Hs.512582

mRNA Expression by UniProt/SwissProt for MAGEA9 Gene

P43362-MAGA9_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta
genes like me logo Genes that share expressions with MAGEA9: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGEA9 Gene

Orthologs for MAGEA9 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 1700080O16Rik 36
  • 39 (a)
ManyToMany
3830417A13Rik 36
  • 39 (a)
ManyToMany
Magea1 36
  • 39 (a)
ManyToMany
Magea10 36
  • 40 (a)
ManyToMany
Magea2 36
  • 39 (a)
ManyToMany
Magea3 36
  • 38 (a)
ManyToMany
Magea4 36
  • 38 (a)
ManyToMany
Magea5 36
  • 40 (a)
ManyToMany
Magea6 36
  • 39 (a)
ManyToMany
Magea8 36
  • 39 (a)
ManyToMany
Species with no ortholog for MAGEA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA9 Gene

ENSEMBL:
Gene Tree for MAGEA9 (if available)
TreeFam:
Gene Tree for MAGEA9 (if available)

Paralogs for MAGEA9 Gene

genes like me logo Genes that share paralogs with MAGEA9: view

Variants for MAGEA9 Gene

Sequence variations from dbSNP and Humsavar for MAGEA9 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs367182 -- 149,785,529(+) TGTTC(C/T)ATATC intron-variant
rs456870 -- 149,781,687(+) CACCC(C/T)GACCA upstream-variant-2KB
rs466116 -- 149,780,010(+) CCACT(A/G)CCACC upstream-variant-2KB
rs111482377 -- 149,780,314(+) AATAA(A/G)AAGAG upstream-variant-2KB
rs113451770 -- 149,785,673(+) GAGTG(C/T)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEA9 Gene

Variant ID Type Subtype PubMed ID
nsv525908 CNV Gain 19592680
nsv518742 CNV Gain 19592680
nsv508809 CNV Insertion 20534489
nsv818041 CNV Gain 17921354

Relevant External Links for MAGEA9 Gene

HapMap Linkage Disequilibrium report
MAGEA9
Human Gene Mutation Database (HGMD)
MAGEA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA9 Gene

Disorders for MAGEA9 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for MAGEA9 Gene including...

Search for MAGEA9 Gene in MalaCards »

(1) University of Copenhagen DISEASES for MAGEA9 Gene

genes like me logo Genes that share disorders with MAGEA9: view

No data available for UniProtKB/Swiss-Prot for MAGEA9 Gene

Publications for MAGEA9 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PMID: 7927540) De Plaen E. … Boon T. (Immunogenetics 1994) 3 4
  3. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner U.C. … Poustka A. (Genomics 1995) 2 3
  4. Molecular and phenotypic variation in patients with severe Hunter syndrome. (PMID: 9147653) Timms K.M. … Gibbs R.A. (Hum. Mol. Genet. 1997) 3 4
  5. Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries. (PMID: 10521804) Serrano A. … Boon T. (Int. J. Cancer 1999) 3

Products for MAGEA9 Gene

Sources for MAGEA9 Gene

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