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MAGEA9 Gene

protein-coding   GIFtS: 51

GC0XP148671
melanoma antigen family A, 9
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MAGE9)
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Aliases &
Descriptions
for MAGEA9

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CT1.9 1, 2, 3
MAGE9 2, 3, 5
MAGEA9A 3
MGC8421 1, 2
OTTHUMP00000024214 2
Descriptions
Cancer/testis antigen 1.9 3
MAGE-9 antigen 2, 3
cancer/testis antigen family 1, member 9 2
melanoma antigen family A, 9 2
melanoma-associated antigen 9 2
External Ids
HGNC: 68071
Entrez Gene: 41082
UniProtKB: P433623
Ensembl: ENSG000001660087
Search outside databases for aliases for MAGEA9 gene

Previous GC identifers: GC0XP143533 GC0XP145914 GC0XP146754 GC0XP147569 GC0XP148569

Summaries
for MAGEA9

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for MAGEA9:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50
to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show
considerable variability, suggesting that the existence of this gene family enables the same
function to be expressed under different transcriptional controls. The MAGEA genes are clustered
at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as
dyskeratosis congenita. [provided by RefSeq]

UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362
Function: Not known, though may play a role in embryonal development and tumor transformation or
aspects of tumor progression

Gene Wiki entry for MAGEA9

Genomic Location
for MAGEA9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MAGEA9 gene  

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MAGEA9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP148671:     (about GC identifiers)

Start:
 148,671,395 bp from pter
End:
 148,677,206 bp from pter
Size:
 5,812 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000023.9  NT_011681.15  

Proteins
for MAGEA9

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362 (See protein sequence)
Recommended Name: Melanoma-associated antigen 9  
Size: 315 amino acids; 35088 Da
Secondary accessions: A8K8A7 Q7Z5K4 Q92910

REFSEQ proteins: NP_005356.1  

ENSEMBL proteins: 
ENSP00000298974 


Human Recombinant Proteins 
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Recombinant Proteins from Abcam (MAGEA9)
Human Recombinant Proteins from Abnova (MAGEA9)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for MAGEA9: 
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Assays for MAGEA9: 
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Protein Domains/
Families
for MAGEA9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR002190 MAGE


   GeneDecks  MAGEA9 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P43362

ProtoNet protein and cluster: P43362

1 Blocks protein family: IPB002190 MAGE protein

UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362
Similarity: Contains 1 MAGE domain

Gene Function
for MAGEA9

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (MAGEA9)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (MAGEA9)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005365

              Applied Biosystems Silencer® siRNAs for MAGEA9

              Sigma-Aldrich siRNA for MAGEA9  
                     Sigma-Aldrich shRNA for MAGEA9  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005365
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005365
                                 untagged cDNA clone in CMV expression vector: NM_005365 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_005365

UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362
Function: Not known, though may play a role in embryonal development and tumor transformation or
aspects of tumor progression

Genatlas biochemistry entry for MAGEA9:
human melanoma antigen,family A,member 9,expressed in melanoma,testis

Pathways & Interactions
for MAGEA9

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for MAGEA9

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGEA9

Transcripts
for MAGEA9

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (MAGEA9)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (MAGEA9)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005365

              Sigma-Aldrich siRNA for MAGEA9  
                     Sigma-Aldrich shRNA for MAGEA9  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_005365  

REFSEQ mRNAs for MAGEA9 gene: 

NM_005365.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_005365  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005365
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005365
                                 untagged cDNA clone in CMV expression vector: NM_005365 

5 DOTS entries:

DT.121317502  DT.92418006  DT.100735256  DT.95328000  DT.100768078 

15 AceView cDNA sequences:

BC002351 CB121911 NM_005365 BE793498 AL557512 AI830281 AY310325 BG288125 
CA431031 AW249285 BX362002 BX365439 BI561505 BF220321 AW248864 

highest scoring ESTs for MAGEA9:

AY310325 BF220168 AW249285 BC002351 BF220321 CB121911 AW248864 BU618634 NM_005365 DB031218 

Unigene Cluster for MAGEA9:

Melanoma antigen family A, 9
Hs.512582  [show with all ESTs]
Unigene Representative Sequence: NM_005365


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA9

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1:                    -     -                                             
SP2:                          -                                             
SP3:                                                                        
SP4:                    -     -     -                                       
SP5:                          -     -                                       

About this scheme

ECgene alternative splicing isoforms for MAGEA9

1 Ensembl transcript including schematic representation:
ENST00000298974  

Expression
for MAGEA9

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAGEA9 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for MAGEA9

1 / 2 / 3

3 probe-sets matching MAGEA9 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

34577_at2, 3 U95-A 2 1.00 0.50 1.00 1.00 U10694 0.20 0.50 0.38 1

210437_at2, 3 U133-A 2 1.00 0.50 -- -- BC002351 0.80 0.88 0.84 1

210437_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TAAGAGAAAT

SOURCE GeneReport for Unigene cluster: Hs.512582

Expression variation in blood from EXPOLDB for MAGEA9

UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck
squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for
testes and placenta

Orthologs
for MAGEA9

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for MAGEA9 gene from 3 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 MAGEA91   -- melanoma antigen family A, 9 67.66(n)
53.73(a)		 492226  XM_549346.2  XP_549346.2 
chimpanzee
(Pan troglodytes)		 MAGEA91   -- melanoma antigen family A, 9 98.62(n)
97.14(a)		 473817  XM_529190.2  XP_529190.1 
cow
(Bos taurus)		 MAGEA9B1   -- similar to Melanoma-associated antigen 4 (MAGE-4 antigen) more 64.86(n)
48.01(a)		 525400  XM_603753.3  XP_603753.3 
About this table        Species with no ortholog for MAGEA9

ENSEMBL Gene Tree for MAGEA9

Paralogs
for MAGEA9

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for MAGEA9 gene
MAGEA9B1 2  MAGEA32  MAGEA2B2  MAGEA82  MAGEA122  MAGEA42  MAGEA112  MAGEA12  
MAGEA102  MAGEA62  MAGEA22  

SNPs/Variants
for MAGEA9

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --

Disorders & Mutations
for MAGEA9

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 300342

Medical News
for MAGEA9

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for MAGEA9

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

9 PubMed articles for MAGEA9 gene:

Search for MAGEA9

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing MAGEA9

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 4108 HGNC: 6807 AceView: MAGEA9 Ensembl:ENSG00000166008 euGenes: HUgn4108
ECgene: MAGEA9 H-InvDB: MAGEA9

Other Databases showing MAGEA9

(According to HUGE)
About This Section

   --

Specialized Databases showing MAGEA9

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
ATLAS Chromosomes in Cancer entry for MAGEA9 Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies
for MAGEA9

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for MAGEA9

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for MAGEA9:
 TaqMan ® Gene Expression Assays
  Free SNP selection tool



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 Antibodies for MAGEA9

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