MAGEA9 Gene
protein-coding GIFtS: 49
GCID: GC0XP148863
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|
melanoma antigen family A, 9
(Previous symbol: MAGE9)
| |
Aliases
for MAGEA9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family A, 91 2 | | MGC84211 | | MAGE91 2 3 5 | | Cancer/Testis Antigen Family 1, Member 92 | | CT1.91 2 3 | | Melanoma-Associated Antigen 92 | | Cancer/Testis Antigen 1.92 3 | | MAGEA9A3 | | MAGE-9 Antigen2 3 | | |
Export aliases for MAGEA9 gene to outside databasesPrevious GC identifers: GC0XP143533 GC0XP145914 GC0XP146754 GC0XP147569 GC0XP148569 GC0XP148671 GC0XM137617 |
Summaries
for MAGEA9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEA9:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequenceidentity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggestingthat the existence of this gene family enables the same function to be expressed under different transcriptionalcontrols. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditarydisorders, such as dyskeratosis congenita. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumorprogression
Gene Wiki entry for MAGEA9
|
Genomic Views
for MAGEA9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEA9 gene promoter:
Nkx3-1 GR Pbx1a SREBP-1c GR-beta LCR-F1 HNF-3beta SREBP-1b SREBP-1a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEA9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28MAGEA9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP148863: view genomic region
(about GC identifiers)
Start:
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148,863,584 bp from pter |
End:
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148,869,399 bp from pter |
Size:
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5,816 bases |
Orientation:
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plus strand |
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Proteins
for MAGEA9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362 (See
protein sequence)Recommended Name: Melanoma-associated antigen 9 Size: 315 amino acids; 35088 Da
Secondary accessions: A8K8A7 Q7Z5K4 Q92910Explore the universe of human proteins at neXtProt for MAGEA9: NX_P43362
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P43362
MAGEA9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005356.1
ENSEMBL proteins: ENSP00000430634 ENSP00000298974 ENSP00000428234 ENSP00000430957 ENSP00000427988
Human Recombinant Protein Products for MAGEA9:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
-- | -- |
MAGEA9 for ontologies About GeneDecksing
MAGEA9 Antibody Products:
Assay Products for MAGEA9: |
Protein
Domains /
Families
for MAGEA9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEA9 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P43362ProtoNet protein and cluster: P43362 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362Similarity: Contains 1 MAGE domain |
Function
for MAGEA9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: MAGA9_HUMAN, P43362Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumorprogression Genatlas biochemistry entry for MAGEA9:human melanoma antigen,family A,member 9,expressed in melanoma,testis
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
-- | -- |
MAGEA9 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for MAGEA9:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA9
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA9 |
|
Pathways & Interactions
for MAGEA9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEA9
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
-- | -- |
MAGEA9 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAGEA9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEA9
Search CenterWatch for drugs/clinical trials and news about MAGEA9 / MAGA9
|
Transcripts
for MAGEA9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEA9 gene: NM_005365.4 5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000439010 ENST00000298974(uc004fdv.3) ENST00000522429 ENST00000519822
ENST00000523516
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA9
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA9
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAGEA9 (NM_005365) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEA9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEA9 |
15 AceView cDNA sequences: NM_005365 BC002351 CB121911 BE793498 BX362002 BX365439 CA431031 AW249285 AI830281 BG288125 AL557512 AY310325 BI561505 BF220321 AW248864
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA9 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|
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| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAGEA9
|
Expression
for MAGEA9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEA9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGAGAAAT
About this image
See MAGEA9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEA9
UniProtKB/Swiss-Prot: MAGA9_HUMAN, P43362Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma,lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta
SABiosciences Custom PCR Arrays for MAGEA9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEA9
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MAGEA9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEA9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEA9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA9 |
Orthologs
for MAGEA9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEA9 gene from 3/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
37(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
25(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
19(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEA9 (if available)
TreeFam Gene Tree for MAGEA9 (if available) |
Paralogs
for MAGEA9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEA9 gene
- MAGEA9B1 2 MAGEC22 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGEA82 MAGED22 MAGEA122 MAGEB172 MAGEB102 MAGEA62 MAGEE12 MAGED12
- MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2 MAGEE22
- MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/37 SIMAP similar genes for MAGEA9 using alignment to 5 protein entries: MAGA9_HUMAN (see all proteins)
(see all similar genes):MAGEA9B MAGEA8 MAGEC4 MAGEA12 MAGEA2 MAGEA6
MAGEA2B MAGEA11 MAGEA3 MAGEA4 MAGEC1 MAGEC3
MAGEA5 TRO MAGEB1 MAGEB17 MAGEB4 MAGEB5
MAGEA9 for paralogs About GeneDecksing
|
Genomic Variants
for MAGEA9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEA9 (148863584 - 148869399 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MAGEA9
3 CNVs: 4177 83832 9355 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEA9 |
|
Disorders
/ Diseases
for MAGEA9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEA9 for disorders About GeneDecksing
OMIM gene information: 300342
OMIM disorders: --
11  diseases for MAGEA9: About MalaCardsdyskeratosis congenita dyskeratosis terminal osseous dysplasia osseous dysplasia
melanoma enophthalmos renal cell carcinoma squamous cell carcinoma
lung carcinoma carcinoma breast carcinoma
1 disease from the University of Copenhagen DISEASES database for MAGEA9:Enophthalmos Export disorders for MAGEA9 gene to outside databases
|
Publications
for MAGEA9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEA9 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with MAGEA9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular and phenotypic variation in patients with severe Hunter syndrome. (PubMed id 9147653)1, 2 Timms K.M.... Gibbs R.A. (1997)
- The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
- Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (1994)
- Terminal osseous dysplasia is caused by a single recu rrent mutation in the FLNA gene. (PubMed id 20598277)2 Sun Y....Breuning M.H. (2010)
- Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. (PubMed id 19147576)1 Aprelikova O....Niederhuber J. (2009)
- High frequency of MAGE-A4 and MAGE-A9 expression in h igh-risk bladder cancer. (PubMed id 19533752)1 Bergeron A....Fradet Y. (2009)
- Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell carcinoma. (PubMed id 15900605)1 Oehlrich N....Zoller M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MAGEA9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEA9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEA9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEA9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEA9 gene:
Search GeneIP for patents involving MAGEA9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEA9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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