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Aliases for MAGEA8 Gene

Aliases for MAGEA8 Gene

  • Melanoma Antigen Family A8 2 3
  • MAGE-8 Antigen 2 3 4
  • MAGE8 3 4 6
  • Cancer/Testis Antigen 1.8 3 4
  • CT1.8 3 4
  • Cancer/Testis Antigen Family 1, Member 8 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma-Associated Antigen 8 3
  • Melanoma Antigen Family A, 8 3
  • Member 8 2

External Ids for MAGEA8 Gene

Previous HGNC Symbols for MAGEA8 Gene

  • MAGE8

Previous GeneCards Identifiers for MAGEA8 Gene

  • GC0XP143633
  • GC0XP146013
  • GC0XP146853
  • GC0XP147668
  • GC0XP148668
  • GC0XP148770
  • GC0XP149009

Summaries for MAGEA8 Gene

Entrez Gene Summary for MAGEA8 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2009]

GeneCards Summary for MAGEA8 Gene

MAGEA8 (Melanoma Antigen Family A8) is a Protein Coding gene. Diseases associated with MAGEA8 include dyskeratosis congenita. An important paralog of this gene is MAGED1.

UniProtKB/Swiss-Prot for MAGEA8 Gene

  • Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA8 Gene

Genomics for MAGEA8 Gene

Regulatory Elements for MAGEA8 Gene

Transcription factor binding sites by QIAGEN in the MAGEA8 gene promoter:

Genomic Location for MAGEA8 Gene

Start:
149,881,141 bp from pter
End:
149,885,835 bp from pter
Size:
4,695 bases
Orientation:
Plus strand

Genomic View for MAGEA8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA8 Gene

Proteins for MAGEA8 Gene

  • Protein details for MAGEA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43361-MAGA8_HUMAN
    Recommended name:
    Melanoma-associated antigen 8
    Protein Accession:
    P43361
    Secondary Accessions:
    • Q9BUN9

    Protein attributes for MAGEA8 Gene

    Size:
    318 amino acids
    Molecular mass:
    35215 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEA8 Gene

Proteomics data for MAGEA8 Gene at MOPED

Post-translational modifications for MAGEA8 Gene

  • Ubiquitination at Lys288
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEA8 Gene

No data available for DME Specific Peptides for MAGEA8 Gene

Domains for MAGEA8 Gene

Protein Domains for MAGEA8 Gene

Suggested Antigen Peptide Sequences for MAGEA8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43361

UniProtKB/Swiss-Prot:

MAGA8_HUMAN :
  • P43361
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEA8: view

No data available for Gene Families for MAGEA8 Gene

Function for MAGEA8 Gene

Molecular function for MAGEA8 Gene

GENATLAS Biochemistry: human melanoma antigen,family A,member 8,expressed in melanoma,testis
UniProtKB/Swiss-Prot Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression

Gene Ontology (GO) - Molecular Function for MAGEA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MAGEA8: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MAGEA8 Gene

Localization for MAGEA8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEA8 Gene COMPARTMENTS Subcellular localization image for MAGEA8 gene
Compartment Confidence
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for MAGEA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAGEA8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAGEA8 Gene

Pathways for MAGEA8 Gene

SuperPathways for MAGEA8 Gene

No Data Available

Interacting Proteins for MAGEA8 Gene

Gene Ontology (GO) - Biological Process for MAGEA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEA8: view

No data available for Pathways by source for MAGEA8 Gene

Transcripts for MAGEA8 Gene

Unigene Clusters for MAGEA8 Gene

Melanoma antigen family A, 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3: -

Relevant External Links for MAGEA8 Gene

GeneLoc Exon Structure for
MAGEA8
ECgene alternative splicing isoforms for
MAGEA8

Expression for MAGEA8 Gene

mRNA expression in normal human tissues for MAGEA8 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEA8 Gene

This gene is overexpressed in Testis (15.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEA8 Gene

SOURCE GeneReport for Unigene cluster for MAGEA8 Gene Hs.522803

mRNA Expression by UniProt/SwissProt for MAGEA8 Gene

P43361-MAGA8_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testis and placenta
genes like me logo Genes that share expressions with MAGEA8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGEA8 Gene

Orthologs for MAGEA8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEA8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEA8 35
  • 99.58 (n)
  • 99.06 (a)
MAGEA8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 36 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 42 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 1700080O16Rik 36
  • 40 (a)
ManyToMany
3830417A13Rik 36
  • 39 (a)
ManyToMany
Magea1 36
  • 42 (a)
ManyToMany
Magea10 36
  • 43 (a)
ManyToMany
Magea2 36
  • 42 (a)
ManyToMany
Magea3 36
  • 42 (a)
ManyToMany
Magea4 36
  • 42 (a)
ManyToMany
Magea5 36
  • 43 (a)
ManyToMany
Magea6 36
  • 42 (a)
ManyToMany
Magea8 36
  • 42 (a)
ManyToMany
Species with no ortholog for MAGEA8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA8 Gene

ENSEMBL:
Gene Tree for MAGEA8 (if available)
TreeFam:
Gene Tree for MAGEA8 (if available)

Paralogs for MAGEA8 Gene

Pseudogenes.org Pseudogenes for MAGEA8 Gene

genes like me logo Genes that share paralogs with MAGEA8: view

Variants for MAGEA8 Gene

Sequence variations from dbSNP and Humsavar for MAGEA8 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_053494 -
VAR_053495 -

Structural Variations from Database of Genomic Variants (DGV) for MAGEA8 Gene

Variant ID Type Subtype PubMed ID
nsv525908 CNV Gain 19592680
essv14876 CNV CNV 17122850
esv22974 CNV Gain 19812545
nsv442819 CNV CNV 18776908
nsv515182 CNV Complex 21397061

Relevant External Links for MAGEA8 Gene

HapMap Linkage Disequilibrium report
MAGEA8
Locus Specific Mutation Databases (LSDB)
MAGEA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA8 Gene

Disorders for MAGEA8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MAGEA8 Gene including...

Search for MAGEA8 Gene in MalaCards »
genes like me logo Genes that share disorders with MAGEA8: view

No data available for UniProtKB/Swiss-Prot for MAGEA8 Gene

Publications for MAGEA8 Gene

  1. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PMID: 7927540) De Plaen E. … Boon T. (Immunogenetics 1994) 3 4
  2. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner U.C. … Poustka A. (Genomics 1995) 2 3
  3. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier L.D. … Marra M. (Genome Res. 1996) 3
  4. Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries. (PMID: 10521804) Serrano A. … Boon T. (Int. J. Cancer 1999) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MAGEA8 Gene

Sources for MAGEA8 Gene

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