MAGEA8 Gene
protein-coding GIFtS: 48
GCID: GC0XP149009
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melanoma antigen family A, 8
(Previous symbol: MAGE8)
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Aliases
for MAGEA8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family A, 81 2 | | MAGE-8 Antigen2 3 | | MAGE81 2 3 5 | | MGC21821 | | CT1.81 2 3 | | Cancer/Testis Antigen Family 1, Member 82 | | Cancer/Testis Antigen 1.82 3 | | Melanoma-Associated Antigen 82 |
Export aliases for MAGEA8 gene to outside databasesPrevious GC identifers: GC0XP143633 GC0XP146013 GC0XP146853 GC0XP147668 GC0XP148668 GC0XP148770 |
Summaries
for MAGEA8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEA8:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequenceidentity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggestingthat the existence of this gene family enables the same function to be expressed under different transcriptionalcontrols. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditarydisorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, havebeen identified. (provided by RefSeq, Oct 2009)
UniProtKB/Swiss-Prot: MAGA8_HUMAN, P43361Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumorprogression
|
Genomic Views
for MAGEA8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011681.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEA8 gene promoter:
p53
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEA8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28MAGEA8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP149009: view genomic region
(about GC identifiers)
Start:
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149,009,941 bp from pter |
End:
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149,014,609 bp from pter |
Size:
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4,669 bases |
Orientation:
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plus strand |
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Proteins
for MAGEA8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGA8_HUMAN, P43361 (See
protein sequence)Recommended Name: Melanoma-associated antigen 8 Size: 318 amino acids; 35215 Da
Secondary accessions: Q9BUN9Explore the universe of human proteins at neXtProt for MAGEA8: NX_P43361
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P43361
MAGEA8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001159872.1 NP_001159873.1 NP_005355.2
ENSEMBL proteins: ENSP00000286482 ENSP00000438293 ENSP00000443776
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
MAGEA8 for ontologies About GeneDecksing
MAGEA8 Antibody Products:
Assay Products for MAGEA8: |
Protein
Domains /
Families
for MAGEA8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEA8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P43361ProtoNet protein and cluster: P43361 UniProtKB/Swiss-Prot: MAGA8_HUMAN, P43361Similarity: Contains 1 MAGE domain |
Function
for MAGEA8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAGA8_HUMAN, P43361Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumorprogression Genatlas biochemistry entry for MAGEA8:human melanoma antigen,family A,member 8,expressed in melanoma,testis
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA8 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
MAGEA8 for ontologies About GeneDecksing
|
Pathways & Interactions
for MAGEA8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEA8
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
MAGEA8 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAGEA8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEA8
Search CenterWatch for drugs/clinical trials and news about MAGEA8 / MAGA8
|
Transcripts
for MAGEA8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEA8 gene (3 alternative transcripts): NM_001166400.1 NM_001166401.1 NM_005364.4 Unigene Cluster for MAGEA8: Melanoma antigen family A, 8 Hs.522803 [show with all ESTs]Unigene Representative Sequence: NM_0011664005 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000286482 ENST00000345830 ENST00000493910 ENST00000535454(uc022cgo.1)
ENST00000542674(uc004fdw.2 uc022cgp.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA8 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MAGEA8 (NM_005364) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AK313943.1 BC002455.2 BC012744.2 BC098120.1 BT007340.1 2 DOTS entries: DT.207126 DT.100768791 24/33 AceView cDNA sequences (see all 33): BQ434005 BI092675 CR619399 BC012744 BC002455 NM_005364 AA045817 BX360398 BI087522 BX102591 BE388427 CF994013 BE892022 BI087592 BU188475 BE275893 AI032153 BX399615 BE729897 BX417414 BE407511 BG481340 BE727811 BT007340
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA8 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c |
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| SP1: | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAGEA8
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Expression
for MAGEA8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEA8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATAAAGAC
About this image
See MAGEA8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEA8
SOURCE GeneReport for Unigene cluster: Hs.522803
UniProtKB/Swiss-Prot: MAGA8_HUMAN, P43361Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma,lung carcinoma and breast carcinoma, but not in normal tissues except for testis and placenta
SABiosciences Custom PCR Arrays for MAGEA8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEA8
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA8 |
Orthologs
for MAGEA8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEA8 gene from 3/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
37(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
28(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
20(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEA8 (if available)
TreeFam Gene Tree for MAGEA8 (if available) |
Paralogs
for MAGEA8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEA8 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12 MAGED12
- MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2 MAGEE22
- MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/39 SIMAP similar genes for MAGEA8 using alignment to 3 protein entries: MAGA8_HUMAN (see all proteins)
(see all similar genes):MAGEA9B MAGEA9 MAGEA12 MAGEA4 MAGEA1 MAGEA2B
MAGEA2 MAGEA6 MAGEA11 MAGEA3 MAGEC4 MAGEA5
MAGEB16 MAGEC3 MAGEH1 MAGEC1 MAGE-B1 MAGEA13P
MAGEA8 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MAGEA8
PGOHUM00000260994
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Genomic Variants
for MAGEA8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEA8 (149009941 - 149014609 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for MAGEA8
6 CNVs: 31571 3258 74073 38929 4177 83832
Locus Specific Mutation Databases (LSDB): MAGEA8
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEA8 |
|
Disorders
/ Diseases
for MAGEA8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEA8 for disorders About GeneDecksing
OMIM gene information: 300341
OMIM disorders: --
7  diseases for MAGEA8: About MalaCardsdyskeratosis congenita dyskeratosis melanoma squamous cell carcinoma
lung carcinoma breast carcinoma carcinoma
Export disorders for MAGEA8 gene to outside databases
|
Publications
for MAGEA8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEA8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAGEA8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
- Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (1994)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries. (PubMed id 10521804)1 Serrano A....Boon T. (1999)
- Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (1996)
|
External Searches for MAGEA8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEA8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEA8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEA8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEA8 gene:
Search GeneIP for patents involving MAGEA8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEA8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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