Aliases for MAGEA6 Gene
Aliases for MAGEA6 Gene
External Ids for MAGEA6 Gene
- HGNC: 6804
- Entrez Gene: 4105
- Ensembl: ENSG00000197172
- OMIM: 300176
- UniProtKB: P43360
Previous HGNC Symbols for MAGEA6 Gene
- MAGE6
Previous GeneCards Identifiers for MAGEA6 Gene
- GC0XU990097
- GC0XP148524
- GC0XP149615
- GC0XM150553
- GC0XP150484
- GC0XP151537
- GC0XP151617
- GC0XP151867
Summaries for MAGEA6 Gene
-
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for MAGEA6 Gene
MAGEA6 (MAGE Family Member A6) is a Protein Coding gene. Diseases associated with MAGEA6 include Melanoma and Terminal Osseous Dysplasia. An important paralog of this gene is MAGEA3.
UniProtKB/Swiss-Prot for MAGEA6 Gene
-
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA6 Gene
Genomics for MAGEA6 Gene
Regulatory Elements for MAGEA6 Gene
Enhancers for MAGEA6 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH0XG152641 | 0.5 | ENCODE | 7.7 | +128.4 | 128351 | 0.8 | POLR2A SMARCA4 TEAD4 POU5F1 | MAGEA6 GABRQ LOC100420250 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MAGEA6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the MAGEA6 gene promoter:
Regulatory Element Products
Genomic Location for MAGEA6 Gene
- Chromosome:
- X
- Start:
- 152,766,136 bp from pter
- End:
- 152,769,747 bp from pter
- Size:
- 3,612 bases
- Orientation:
- Minus strand
Genomic View for MAGEA6 Gene
Genes around MAGEA6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq28 by Ensembl
- Xq28 by Entrez Gene
- Xq28 by HGNC
MAGEA6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MAGEA6 Gene
Proteins for MAGEA6 Gene
-
Protein details for MAGEA6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P43360-MAGA6_HUMAN
- Recommended name:
- Melanoma-associated antigen 6
- Protein Accession:
- P43360
- A8IF93
- Q6NW44
Protein attributes for MAGEA6 Gene
- Size:
- 314 amino acids
- Molecular mass:
- 34891 Da
- Quaternary structure:
-
- Interacts with TRIM28.
Protein Expression for MAGEA6 Gene
Post-translational modifications for MAGEA6 Gene
Other Protein References for MAGEA6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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- GeneTex MAGEA6 antibody for MAGEA6
-
Santa Cruz Biotechnology (SCBT) Antibodies for MAGEA6
Protein Products
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- antibodies-online Proteins for MAGEA6: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for MAGEA6
No data available for DME Specific Peptides for MAGEA6 Gene
Domains & Families for MAGEA6 Gene
Gene Families for MAGEA6 Gene
- HGNC:
Protein Domains for MAGEA6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MAGEA6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for MAGEA6 Gene
Function for MAGEA6 Gene
Molecular function for MAGEA6 Gene
- GENATLAS Biochemistry:
- human melanoma antigen,family A,member 6,expressed in melanoma,testis
- UniProtKB/Swiss-Prot Function:
- Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005515 | protein binding | IPI | 20864041 |
Phenotypes for MAGEA6 Gene
- GenomeRNAi human phenotypes for MAGEA6:
Animal Model Products
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-
-
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-
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miRNA for MAGEA6 Gene
- miRTarBase miRNAs that target MAGEA6
miRNA Products
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Inhibitory RNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for MAGEA6
-
ViGene Biosciences adenoviral particle packaged cDNA for MAGEA6 gene
-
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-
ViGene Biosciences ready-to-package AAV shRNAs for MAGEA6 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEA6 Gene
Localization for MAGEA6 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 2 |
| plasma membrane | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAGEA6 Gene
Pathways & Interactions for MAGEA6 Gene
No Data Available
Interacting Proteins for MAGEA6 Gene
Selected Interacting proteins:
P43360-MAGA6_HUMAN
ENSP00000329199
for MAGEA6 Gene via
IID
UniProtKB
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for MAGEA6 Gene
Transcripts for MAGEA6 Gene
mRNA/cDNA for MAGEA6 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (138) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MAGEA6 Gene
CRISPR Products
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OriGene CRISPR knockouts for MAGEA6
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Santa Cruz Biotechnology (SCBT) CRISPR for MAGEA6
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miRNA Products
- Search ViGene Biosciences for MAGEA6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for MAGEA6
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ViGene Biosciences ready-to-package AAV shRNAs for MAGEA6 gene
Clone Products
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MAGEA6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAGEA6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for MAGEA6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for MAGEA6 Gene
This gene is overexpressed in Testis (x49.2).
This gene is overexpressed in Bone (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAGEA6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MAGEA6 Gene:
MAGEA6SOURCE GeneReport for Unigene cluster for MAGEA6 Gene:
Hs.441113mRNA Expression by UniProt/SwissProt for MAGEA6 Gene:
P43360-MAGA6_HUMAN
Tissue specificity:
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
Evidence on tissue expression from TISSUES for MAGEA6 Gene
- Skin(2.8)
Primer Products
-
OriGene qPCR primer pairs for MAGEA6
-
OriGene qPCR primer pairs and template standards for MAGEA6
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEA6 Gene
Orthologs for MAGEA6 Gene
This gene was present in the common ancestor of human and mouse.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Magea10 35 |
|
ManyToMany | |
| Magea6 35 |
|
ManyToMany | |||
| 1700080O16Rik 35 |
|
ManyToMany | |||
| 3830417A13Rik 35 |
|
ManyToMany | |||
| Magea1 35 |
|
ManyToMany | |||
| Magea3 35 |
|
ManyToMany | |||
| Magea5 35 |
|
ManyToMany | |||
| Magea8 35 |
|
ManyToMany | |||
| Magea2 35 |
|
ManyToMany | |||
| Magea4 35 |
|
ManyToMany |
- Species where no ortholog for MAGEA6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MAGEA6 Gene
Paralogs for MAGEA6 Gene
- MAGEA3 5
- MAGEA12 5
- MAGEA2B 5
- MAGEA2 5
- MAGEA4 5
- MAGEA1 5
- MAGEA8 5
- MAGEA11 5
- MAGEA9 5
- MAGEA9B 5
- MAGEA10 5
- MAGEB16 5
- MAGEB1 5
- MAGEB4 5
- MAGEB18 5
- MAGEB2 5
- MAGEB17 5
- MAGEB10 5
- MAGEC2 5
- MAGEC1 5
- MAGEB3 5
- MAGEB6P1 5
- MAGEB6 5
- MAGEC3 5
- MAGEL2 5
- TRO 5
- MAGEE1 5
- MAGEB5 5
- MAGED2 5
- MAGED4 5
- MAGED4B 5
- NSMCE3 5
- MAGED1 5
- MAGEE2 5
- MAGEF1 5
- NDN 5
- MAGEA3 34
(38) SIMAP similar genes for MAGEA6 Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for MAGEA6 Gene
Variants for MAGEA6 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs112483246 | -- | 152,771,535(-) | GATTG(C/T)GTCAA | intron-variant, upstream-variant-2KB | |
| rs113065219 | -- | 152,770,974(-) | AAAAA(C/G)CTTGA | intron-variant, upstream-variant-2KB | |
| rs116616525 | -- | 152,766,657(-) | GGCCA(G/T)TGCAC | utr-variant-3-prime | |
| rs12846936 | -- | 152,766,841(-) | TATGA(A/G)TTCCT | reference, synonymous-codon | |
| rs137998711 | -- | 152,767,007(+) | CGACT(C/G)TGCCC | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758901 | CNV | gain | 17122850 |
| nsv1119372 | CNV | duplication | 24896259 |
| nsv1148882 | CNV | duplication | 26484159 |
Residual Variation Intolerance Score:
84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.20;
61.97% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for MAGEA6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MAGEA6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA6 Gene
Disorders for MAGEA6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melanoma |
|
|
| terminal osseous dysplasia |
|
|
| dyskeratosis congenita |
|
|
Search MAGEA6 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for MAGEA6
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MAGEA6
No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA6 Gene
Publications for MAGEA6 Gene
- MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle J.M. … Potts P.R. (Mol. Cell 2010) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma. (PMID: 12631591) Tatsumi T. … Storkus W.J. (Clin. Cancer Res. 2003) 3 22 64
- The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner U.C. … Poustka A. (Genomics 1995) 2 3 64
- Sequence analysis of the MAGE gene family encoding human tumor- rejection antigens. (PMID: 7642112) Imai Y. … Itoh K. (Gene 1995) 3 4 64
Products for MAGEA6 Gene
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- VectorBuilder custom plasmid, inducible vectors for MAGEA6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MAGEA6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MAGEA6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
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- (115) ProteomicsDB
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- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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