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MAGEA6 Gene(Protein Coding)

MAGE Family Member A6

GCID:
GC0XM152766
GIFtS:
49
Genes Participants
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Aliases for MAGEA6 Gene

Aliases for MAGEA6 Gene

  • MAGE Family Member A6 2 3 5
  • MAGE-6 Antigen 2 3 4
  • Melanoma Antigen Family A6 2 3
  • Cancer/Testis Antigen 1.6 3 4
  • MAGE3B Antigen 3 4
  • MAGE6 3 4
  • CT1.6 3 4
  • Cancer/Testis Antigen Family 1, Member 6 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma-Associated Antigen 6 2
  • Melanoma Antigen Family A, 6 3
  • Melanoma Antigen Family A 6 2
  • Member 6 2
  • MAGE-3b 3
  • MAGE3B 3

External Ids for MAGEA6 Gene

Previous HGNC Symbols for MAGEA6 Gene

  • MAGE6

Previous GeneCards Identifiers for MAGEA6 Gene

  • GC0XU990097
  • GC0XP148524
  • GC0XP149615
  • GC0XM150553
  • GC0XP150484
  • GC0XP151537
  • GC0XP151617
  • GC0XP151867

Summaries for MAGEA6 Gene

Entrez Gene Summary for MAGEA6 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for MAGEA6 Gene

MAGEA6 (MAGE Family Member A6) is a Protein Coding gene. Diseases associated with MAGEA6 include Melanoma and Dyskeratosis Congenita. An important paralog of this gene is MAGEC3.

UniProtKB/Swiss-Prot for MAGEA6 Gene

  • Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA6 Gene

Genomics for MAGEA6 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MAGEA6 Gene


Transcription factor binding sites by QIAGEN in the MAGEA6 gene promoter:

Genomic Location for MAGEA6 Gene

Chromosome:
X
Start:
152,766,136 bp from pter
End:
152,769,747 bp from pter
Size:
3,612 bases
Orientation:
Minus strand

Genomic View for MAGEA6 Gene

Genes around MAGEA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAGEA6 Gene

Proteins for MAGEA6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MAGEA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43360-MAGA6_HUMAN
    Recommended name:
    Melanoma-associated antigen 6
    Protein Accession:
    P43360
    Secondary Accessions:
    • A8IF93
    • Q6NW44

    Protein attributes for MAGEA6 Gene

    Size:
    314 amino acids
    Molecular mass:
    34891 Da
    Quaternary structure:
    • Interacts with TRIM28.

neXtProt entry for MAGEA6 Gene

Proteomics data for MAGEA6 Gene at MOPED

Protein Expression for MAGEA6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MAGEA6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEA6 Gene

Domains & Families for MAGEA6 Gene

Gene Families for MAGEA6 Gene

HGNC:

Protein Domains for MAGEA6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43360

UniProtKB/Swiss-Prot:

MAGA6_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEA6: view

Function for MAGEA6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for MAGEA6 Gene

GENATLAS Biochemistry:
human melanoma antigen,family A,member 6,expressed in melanoma,testis
UniProtKB/Swiss-Prot Function:
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines.

Phenotypes for MAGEA6 Gene

GenomeRNAi human phenotypes for MAGEA6:
genes like me logo Genes that share phenotypes with MAGEA6: view

Animal Model Products

miRNA for MAGEA6 Gene

miRTarBase miRNAs that target MAGEA6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEA6 Gene

Localization for MAGEA6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEA6 Gene COMPARTMENTS Subcellular localization image for MAGEA6 gene
Compartment Confidence
cytosol 2
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEA6 Gene

Pathways & Interactions for MAGEA6 Gene

SuperPathways for MAGEA6 Gene

PathCards logoMore details on SuperPathways for MAGEA6
No Data Available

Interacting Proteins for MAGEA6 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000329199%0d%0a9606.ENSP00000287437%0d%0a9606.ENSP00000323439%0d%0a9606.ENSP00000355077%0d%0a9606.ENSP00000354957%0d%0a9606.ENSP00000358019%0d%0a
Selected Interacting proteins: ENSP00000329199 P43360-MAGA6_HUMAN for MAGEA6 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for MAGEA6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEA6 Gene

Drugs & Compounds for MAGEA6 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MAGEA6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MAGEA6 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(183) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEA6 Gene

Melanoma antigen family A, 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA6 Gene

No ASD Table

Relevant External Links for MAGEA6 Gene

GeneLoc Exon Structure for
MAGEA6
ECgene alternative splicing isoforms for
MAGEA6

Expression for MAGEA6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for MAGEA6 Gene

mRNA expression in normal human tissues for MAGEA6 Gene
mRNA expression by BioGPS for MAGEA6 GenemRNA expression by GTEx for MAGEA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEA6 Gene

This gene is overexpressed in Testis (x49.2).

Protein differential expression in normal tissues from HIPED for MAGEA6 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEA6 Gene



SOURCE GeneReport for Unigene cluster for MAGEA6 Gene Hs.441113

mRNA Expression by UniProt/SwissProt for MAGEA6 Gene

P43360-MAGA6_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
genes like me logo Genes that share expression patterns with MAGEA6: view

Protein tissue co-expression partners for MAGEA6 Gene

- Elite partner

Primer Products

Orthologs for MAGEA6 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA6 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
 Mammalia 1700080O16Rik 36
  • 38 (a)
 ManyToMany
3830417A13Rik 36
  • 38 (a)
 ManyToMany
Magea1 36
  • 38 (a)
 ManyToMany
Magea10 36
  • 40 (a)
 ManyToMany
Magea2 36
  • 37 (a)
 ManyToMany
Magea3 36
  • 38 (a)
 ManyToMany
Magea4 36
  • 37 (a)
 ManyToMany
Magea5 36
  • 38 (a)
 ManyToMany
Magea6 36
  • 39 (a)
 ManyToMany
Magea8 36
  • 38 (a)
 ManyToMany
Species with no ortholog for MAGEA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA6 Gene

ENSEMBL:
Gene Tree for MAGEA6 (if available)
TreeFam:
Gene Tree for MAGEA6 (if available)

Paralogs for MAGEA6 Gene

Paralogs for MAGEA6 Gene

(38) SIMAP similar genes for MAGEA6 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MAGEA6 Gene

genes like me logo Genes that share paralogs with MAGEA6: view

Variants for MAGEA6 Gene

Sequence variations from dbSNP and Humsavar for MAGEA6 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs7056365 - 152,767,196(+) CTTCA(G/T)CAAAG reference, missense
rs2014908 -- 152,771,171(+) TGCAC(A/T)CCTCG upstream-variant-2KB
rs5925209 -- 152,770,225(-) ACGAA(A/G)ACGAC upstream-variant-2KB
rs5925210 -- 152,767,840(-) CTGAC(C/G)TGGAG utr-variant-5-prime
rs5970360 -- 152,767,907(-) GCATG(C/T)GCTGG intron-variant, utr-variant-5-prime

Variation tolerance for MAGEA6 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 61.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MAGEA6 Gene

Disorders for MAGEA6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAGEA6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
dyskeratosis congenita
  • revesz syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEA6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEA6
genes like me logo Genes that share disorders with MAGEA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA6 Gene

Publications for MAGEA6 Gene

  1. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. (PMID: 20864041) Doyle J.M. … Potts P.R. (Mol. Cell 2010) 3 4 67
  2. MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma. (PMID: 12631591) Tatsumi T. … Storkus W.J. (Clin. Cancer Res. 2003) 3 23
  3. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner U.C. … Poustka A. (Genomics 1995) 2 3
  4. A Comprehensive Expression Analysis of Cancer Testis Antigens in Head and Neck Squamous Cell Carcinoma Revels MAGEA3/6 as a Marker for Recurrence. (PMID: 25564441) ZamunAcr F.T. … Vettore A.L. (Mol. Cancer Ther. 2015) 3
  5. Degradation of AMPK by a cancer-specific ubiquitin ligase. (PMID: 25679763) Pineda C.T. … Potts P.R. (Cell 2015) 3

Products for MAGEA6 Gene

Sources for MAGEA6 Gene

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