MAGEA6 Gene
protein-coding GIFtS: 52
GCID: GC0XP151867
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melanoma antigen family A, 6 (Previous symbol: MAGE6)
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Aliases for MAGEA6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family A, 61 2 | | MAGE3B Antigen2 3 | | MAGE61 2 3 5 | | MAGE-3b2 | | CT1.61 2 3 | | MAGE3B2 | | Cancer/Testis Antigen 1.62 3 | | Cancer/Testis Antigen Family 1, Member 62 | | MAGE-6 Antigen2 3 | | Melanoma-Associated Antigen 62 |
Export aliases for MAGEA6 gene to outside databasesPrevious GC identifers: GC0XU990097 GC0XP148524 GC0XP149615 GC0XM150553 GC0XP150484 GC0XP151537 GC0XP151617 |
Summaries for MAGEA6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for MAGEA6: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequenceidentity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggestingthat the existence of this gene family enables the same function to be expressed under different transcriptionalcontrols. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditarydisorders, such as dyskeratosis congenita. Two transcript variants encoding the same protein have been identified forthis gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360Function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-proteinligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed toact through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May playa role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma celllines
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Genomic Views for MAGEA6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MAGEA6 gene promoter: Bach1 p53 Olf-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEA6
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA6 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28MAGEA6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP151867: view genomic region
(about GC identifiers)
Start:
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151,867,214 bp from pter |
End:
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151,870,825 bp from pter |
Size:
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3,612 bases |
Orientation:
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plus strand |
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Proteins for MAGEA6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360 (See
protein sequence)Recommended Name: Melanoma-associated antigen 6 Size: 314 amino acids; 34891 Da
Subunit: Interacts with TRIM28
Caution: In vitro experiments by PubMed:17942928 measuring cell viability in melanoma cell lines used siRNA specificfor MAGEA3 and MAGEA6
Secondary accessions: A8IF93 Q6NW44Explore the universe of human proteins at neXtProt for MAGEA6: NX_P43360
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P43360 MAGEA6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_005354.1 NP_787064.1 ENSEMBL proteins: ENSP00000329199 ENSP00000403303 ENSP00000401806 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
MAGEA6 for ontologies About GeneDecksing
MAGEA6 Antibody Products: Assay Products for MAGEA6: |
Protein
Domains / Families for MAGEA6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEA6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P43360ProtoNet protein and cluster: P43360 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360Similarity: Contains 1 MAGE domain |
Function for MAGEA6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360Function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-proteinligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed toact through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May playa role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma celllines Genatlas biochemistry entry for MAGEA6:human melanoma antigen,family A,member 6,expressed in melanoma,testis
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA6 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA6 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005515 | protein binding |
IPI | -- |
MAGEA6 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MAGEA6:
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Pathways & Interactions for MAGEA6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEA6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/48 Interacting proteins for MAGEA6 (P433601, 3 ENSP000003291994) via UniProtKB, MINT, STRING, and/or I2D (see all 48)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
MAGEA6 for ontologies About GeneDecksing
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Drugs & Compounds for MAGEA6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for MAGEA6 Search CenterWatch for drugs/clinical trials and news about MAGEA6 / MAGA6 
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Transcripts for MAGEA6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MAGEA6 gene (2 alternative transcripts): NM_005363.2 NM_175868.1 Unigene Cluster for MAGEA6: Melanoma antigen family A, 6 Hs.441113 [show with all ESTs]Unigene Representative Sequence: BX6406003 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000329342(uc004ffq.1 uc004ffr.1) ENST00000412733 ENST00000457643
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA6 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA6 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MAGEA6 (NM_005363) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEA6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEA6  |
Additional cDNA sequence: AK289437.1 BC041599.1 BC067731.1 BX640600.1 D32076.1 EU161101.1 U10339.1 8 DOTS entries: DT.208961 DT.91772022 DT.91861095 DT.100777809 DT.97795237 DT.100029589 DT.100699310 DT.100777807 24/183 AceView cDNA sequences (see all 183): BG575302 BC063681 BM760598 BM015882 BU182773 BC005963 BX505148 BQ431490 CA415709 BF219695 BM846958 CA488474 NM_153488 AW628104 BM549169 NM_005361 AA905896 BE795782 BE901056 CA429655 NM_005362 BQ436888 BC017389 CR594285 GeneLoc Exon Structure
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Expression for MAGEA6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEA6 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See MAGEA6 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MAGEA6
SOURCE GeneReport for Unigene cluster: Hs.441113 UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma,lung carcinoma and breast carcinoma, but not in normal tissues except for testes SABiosciences Custom PCR Arrays for MAGEA6
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEA6 Browse OriGene validated miRNA SYBR primer pairs
| |  | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MAGEA6 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEA6 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEA6 |
Orthologs for MAGEA6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEA6 gene from 3/14 species (see all 14) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
lizard (Anolis carolinensis) |
Reptilia |
-- |
-- |
35(a) |
1 → many |
1(205669616-205678308) |
zebrafish (Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
25(a) |
1 → many |
23(13012414-13025121) |
fruit fly (Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
21(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEA6 (if available) TreeFam Gene Tree for MAGEA6 (if available)  |
Paralogs for MAGEA6 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for MAGEA6 gene
- MAGEA31 2 MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12
- MAGED42 MAGEA82 MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEE12
- MAGED12 MAGEA22 MAGEC32 NDN2 MAGEB22 MAGEB32 MAGED4B2 MAGEE22
- MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/38 SIMAP similar genes for MAGEA6 using alignment to 5 protein entries: MAGA6_HUMAN (see all proteins)
(see all similar genes):MAGEA3 MAGEA12 MAGEA2B MAGEA2 MAGEA5 MAGEA4 MAGEA8 MAGEA9B MAGEA9 MAGEA1 MAGEA11 MAGEC4 MAGEC3 MAGEH1 MAGEA13P TRO MAGEC1 MAGEB5
MAGEA6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MAGEA6 PGOHUM00000241601
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Genomic Variants for MAGEA6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr X pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for MAGEA6 (151867214 - 151870825 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MAGEA6: --  | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases for MAGEA6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEA6 for disorders About GeneDecksing
OMIM gene information: 300176
OMIM disorders: --
11 diseases for MAGEA6: About MalaCardsdyskeratosis congenita dyskeratosis terminal osseous dysplasia osseous dysplasia melanoma oral squamous cell carcinoma squamous cell carcinoma renal cell carcinoma carcinoma lung carcinoma breast carcinoma 1 disease from the University of Copenhagen DISEASES database for MAGEA6:Melanoma Export disorders for MAGEA6 gene to outside databases
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Publications for MAGEA6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEA6 gene, integrated from 9 sources (see all 20): (articles sorted by number of sources associating them with MAGEA6) | |  | Utopia: connect your pdf to the dynamic world of online information |
- MAGE-RING protein complexes comprise a family of E3 u biquitin ligases. (PubMed id 20864041)1, 2 Doyle J.M....Potts P.R. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
- Sequence analysis of the MAGE gene family encoding human tumor- rejection antigens. (PubMed id 7642112)1, 2 Imai Y.... Itoh K. (1995)
- Cloning and analysis of MAGE-1-related genes. (PubMed id 8037761)1, 2 Ding M.... Fenton R.G. (1994)
- Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (1994)
- MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma. (PubMed id 12631591)1, 9 Tatsumi T....Storkus W.J. (2003)
- MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation anal ysis in induced sputum from patients with lung cancer and non-malignant lung dis eases. (PubMed id 22134685)1 Shin K.C....Jeon C.H. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for MAGEA6 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing MAGEA6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEA6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEA6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for MAGEA6 gene: Search GeneIP for patents involving MAGEA6
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MAGEA6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| |  |  |  |  | | | | | Recombinant Protein for MAGEA6 |
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| | | |  |  |  | | | ThermoFisher Antibodies for MAGEA6 |
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