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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGEA6 Gene

protein-coding   GIFtS: 52
GCID: GC0XP151867

melanoma antigen family A, 6


(Previous symbol: MAGE6)
 Explore 11 diseases affiliated with
MAGEA6 via our new
 Human Malady Compendium 
Biological research products
for MAGEA6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Melanoma Antigen Family A, 61 2     MAGE3B Antigen2 3
MAGE61 2 3 5     MAGE-3b2
CT1.61 2 3     MAGE3B2
Cancer/Testis Antigen 1.62 3     Cancer/Testis Antigen Family 1, Member 62
MAGE-6 Antigen2 3     Melanoma-Associated Antigen 62

External Ids:    HGNC: 68041   Entrez Gene: 41052   Ensembl: ENSG000001971727   OMIM: 3001765   UniProtKB: P433603   

Export aliases for MAGEA6 gene to outside databases

Previous GC identifers: GC0XU990097 GC0XP148524 GC0XP149615 GC0XM150553 GC0XP150484 GC0XP151537 GC0XP151617


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAGEA6:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence
identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting
that the existence of this gene family enables the same function to be expressed under different transcriptional
controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary
disorders, such as dyskeratosis congenita. Two transcript variants encoding the same protein have been identified for
this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360
Function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein
ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to
act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play
a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell
lines




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGEA6 gene promoter:
         Bach1   p53   Olf-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGEA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAGEA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MAGEA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEA6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP151867:  view genomic region     (about GC identifiers)

Start:
151,867,214 bp from pter      End:
151,870,825 bp from pter
Size:
3,612 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360 (See protein sequence)
Recommended Name: Melanoma-associated antigen 6  
Size: 314 amino acids; 34891 Da
Subunit: Interacts with TRIM28
Caution: In vitro experiments by PubMed:17942928 measuring cell viability in melanoma cell lines used siRNA specific
for MAGEA3 and MAGEA6
Secondary accessions: A8IF93 Q6NW44

Explore the universe of human proteins at neXtProt for MAGEA6: NX_P43360

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P43360

  • MAGEA6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_005354.1  NP_787064.1  

    ENSEMBL proteins: 
     ENSP00000329199   ENSP00000403303   ENSP00000401806  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    MAGEA6 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MAGEA6 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry P43360

    ProtoNet protein and cluster: P43360

    1 Blocks protein family: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360
    Similarity: Contains 1 MAGE domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360
    Function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein
    ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to
    act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play
    a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell
    lines

         Genatlas biochemistry entry for MAGEA6:
    human melanoma antigen,family A,member 6,expressed in melanoma,testis

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--


    MAGEA6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MAGEA6:
     Decreased melanin production 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for MAGEA6 (P433601, 3 ENSP000003291994) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDOSTP396563, ENSP000003641884I2D: score=2 STRING: ENSP00000364188
    SNRNP40Q96DI73, ENSP000002636944I2D: score=2 STRING: ENSP00000263694
    CCDC47Q96A333, ENSP000002257264I2D: score=1 STRING: ENSP00000225726
    GTF2IP783473, ENSP000003225424I2D: score=1 STRING: ENSP00000322542
    HELLSQ9NRZ93, ENSP000002390274I2D: score=1 STRING: ENSP00000239027
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    MAGEA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAGEA6
    Search CenterWatch for drugs/clinical trials and news about MAGEA6 / MAGA6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAGEA6 gene (2 alternative transcripts): 
    NM_005363.2  NM_175868.1  

    Unigene Cluster for MAGEA6:

    Melanoma antigen family A, 6
    Hs.441113  [show with all ESTs]
    Unigene Representative Sequence: BX640600
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329342(uc004ffq.1 uc004ffr.1) ENST00000412733 ENST00000457643


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    Additional cDNA sequence: 

    AK289437.1 BC041599.1 BC067731.1 BX640600.1 D32076.1 EU161101.1 U10339.1 

    8 DOTS entries:

    DT.208961  DT.91772022  DT.91861095  DT.100777809  DT.97795237  DT.100029589  DT.100699310  DT.100777807 

    24/183 AceView cDNA sequences (see all 183):

    BG575302 BC063681 BM760598 BM015882 BU182773 BC005963 BX505148 BQ431490 
    CA415709 BF219695 BM846958 CA488474 NM_153488 AW628104 BM549169 NM_005361 
    AA905896 BE795782 BE901056 CA429655 NM_005362 BQ436888 BC017389 CR594285 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGEA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MAGEA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAGEA6

    SOURCE GeneReport for Unigene cluster: Hs.441113

    UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360
    Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma,
    lung carcinoma and breast carcinoma, but not in normal tissues except for testes

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    In Situ
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for MAGEA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAGEA6 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    35(a)
    1 → many
    1(205669616-205678308)
    zebrafish
    (Danio rerio)
    Actinopterygii ndnl26
    necdin-like 2
    25(a)
    1 → many
    23(13012414-13025121)
    fruit fly
    (Drosophila melanogaster)
    Insecta MAGE6
    MAGE
    21(a)
    1 → many
    3R(2979960-2980898)


    ENSEMBL Gene Tree for MAGEA6 (if available)
    TreeFam Gene Tree for MAGEA6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGEA6 gene
    MAGEA31 2  MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB42  MAGEB12  MAGEC12  
    MAGED42  MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEE12  
    MAGED12  MAGEA22  MAGEC32  NDN2  MAGEB22  MAGEB32  MAGED4B2  MAGEE22  
    MAGEA42  MAGEA12  MAGEA102  MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  
    MAGEA112  NDNL22  MAGEF12  
    18/38 SIMAP similar genes for MAGEA6 using alignment to 5 protein entries:     MAGA6_HUMAN (see all proteins) (see all similar genes):
    MAGEA3    MAGEA12    MAGEA2B    MAGEA2    MAGEA5    MAGEA4
    MAGEA8    MAGEA9B    MAGEA9    MAGEA1    MAGEA11    MAGEC4
    MAGEC3    MAGEH1    MAGEA13P    TRO    MAGEC1    MAGEB5

    MAGEA6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MAGEA6
    PGOHUM00000241601


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/49 NCBI SNPs in MAGEA6 are shown (see all 49    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2015308551,2
    --151865980(+) TGAAA-/TTACAT 2 -- us2k10--------
    rs1444813821,2
    C,F--151869488(+) CACCAG/CATCCT 4 /H /D mis11Minor allele frequency- C:0.00NA 3032
    rs1496738971,2
    C,F--151869619(+) GAGTCT/CGAGTT 4 /S syn11Minor allele frequency- C:0.00NA 4546
    rs1426349541,2
    C,--151869647(+) GGAAGG/TTGGCC 4 V L mis11Minor allele frequency- T:0.00NA 4552
    rs1505573421,2
    C,F--151869653(+) TGGCCA/GAGTTG 4 K E mis11Minor allele frequency- G:0.00NA 4542
    rs1406607901,2
    C,F--151869684(+) GTATCG/AAGCCA 4 /Q /R mis11Minor allele frequency- A:0.00NA 4552
    rs1478796391,2
    C,--151869718(+) ATGCTG/AGGGAG 4 /L syn11Minor allele frequency- A:0.00NA 4552
    rs1414939431,2
    F--151869727(+) AGTGTC/TGTCGG 4 V syn11Minor allele frequency- T:0.00NA 4552
    rs1500148781,2
    C,F--151869731(+) TCGTCG/AGAAAT 4 /R /G mis11Minor allele frequency- A:0.00NA 4552
    rs1452282681,2
    C--151869738(+) AAATTG/CGCAGT 4 /S /W mis11Minor allele frequency- C:0.00NA 4552

    HapMap Linkage Disequilibrium report for MAGEA6 (151867214 - 151870825 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAGEA6: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MAGEA6 for disorders           About GeneDecksing

    OMIM gene information: 300176    OMIM disorders: --

    11 diseases for MAGEA6:    About MalaCards
    dyskeratosis congenita    dyskeratosis    terminal osseous dysplasia    osseous dysplasia
    melanoma    oral squamous cell carcinoma    squamous cell carcinoma    renal cell carcinoma
    carcinoma    lung carcinoma    breast carcinoma

    1 disease from the University of Copenhagen DISEASES database for MAGEA6:
    Melanoma

    Export disorders for MAGEA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGEA6 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with MAGEA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MAGE-RING protein complexes comprise a family of E3 u biquitin ligases. (PubMed id 20864041)1, 2 Doyle J.M....Potts P.R. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
    4. Sequence analysis of the MAGE gene family encoding human tumor- rejection antigens. (PubMed id 7642112)1, 2 Imai Y.... Itoh K. (1995)
    5. Cloning and analysis of MAGE-1-related genes. (PubMed id 8037761)1, 2 Ding M.... Fenton R.G. (1994)
    6. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (1994)
    7. MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma. (PubMed id 12631591)1, 9 Tatsumi T....Storkus W.J. (2003)
    8. MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation anal ysis in induced sputum from patients with lung cancer and non-malignant lung dis eases. (PubMed id 22134685)1 Shin K.C....Jeon C.H. (2012)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4105 HGNC: 6804 AceView: MAGEA2andMAGEA3andMAGEA12 Ensembl:ENSG00000197172 euGenes: HUgn4105
    ECgene: MAGEA6 H-InvDB: MAGEA6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for MAGEA6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEA6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for MAGEA6 gene:
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