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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGEA6 Gene

protein-coding   GIFtS: 53
GCID: GC0XP151867

Melanoma Antigen Family A, 6


(Previous symbol: MAGE6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Melanoma Antigen Family A, 61 2     Cancer/Testis Antigen Family 11
MAGE61 2 3 5     Melanoma Antigen Family A 61
MAGE-6 Antigen1 2 3     Member 61
Melanoma-Associated Antigen 61 2     MAGE-3b2
Cancer/Testis Antigen 1.62 3     MAGE3B2
CT1.62 3     Cancer/Testis Antigen Family 1, Member 62
MAGE3B Antigen2 3     

External Ids:    HGNC: 68041   Entrez Gene: 41052   Ensembl: ENSG000001971727   OMIM: 3001765   UniProtKB: P433603   

Export aliases for MAGEA6 gene to outside databases

Previous GC identifers: GC0XU990097 GC0XP148524 GC0XP149615 GC0XM150553 GC0XP150484 GC0XP151537 GC0XP151617


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAGEA6 Gene:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence
identity to each other. The promoters and first exons of the MAGEA genes show considerable variability,
suggesting that the existence of this gene family enables the same function to be expressed under different
transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated
in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for MAGEA6 Gene: 
MAGEA6 (melanoma antigen family A, 6) is a protein-coding gene. Diseases associated with MAGEA6 include terminal osseous dysplasia, and oral squamous cell carcinoma. GO annotations related to this gene include protein binding and molecular_function. An important paralog of this gene is MAGEC2.

UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360
Function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein
ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28.
Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate
complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell
viability in melanoma cell lines




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGEA6 gene promoter:
         Bach1   p53   Olf-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGEA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAGEA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MAGEA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEA6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP151867:  view genomic region     (about GC identifiers)

Start:
151,867,214 bp from pter      End:
151,870,825 bp from pter
Size:
3,612 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360 (See protein sequence)
Recommended Name: Melanoma-associated antigen 6  
Size: 314 amino acids; 34891 Da
Subunit: Interacts with TRIM28
Caution: In vitro experiments by PubMed:17942928 measuring cell viability in melanoma cell lines used siRNA
specific for MAGEA3 and MAGEA6
Secondary accessions: A8IF93 Q6NW44

Explore the universe of human proteins at neXtProt for MAGEA6: NX_P43360

Explore proteomics data for MAGEA6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P43360

  • MAGEA6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAGEA6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_005354.1  NP_787064.1  

    ENSEMBL proteins: 
     ENSP00000329199   ENSP00000403303   ENSP00000401806  

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    ProSpec Recombinant Protein for MAGEA6
    Cloud-Clone Corp. Proteins for MAGEA6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    MAGEA6 for ontologies           About GeneDecksing



    MAGEA6 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry P43360

    ProtoNet protein and cluster: P43360

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360
    Similarity: Contains 1 MAGE domain


    MAGEA6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAGA6_HUMAN, P43360
    Function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein
    ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28.
    Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate
    complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell
    viability in melanoma cell lines

         Genatlas biochemistry entry for MAGEA6:
    human melanoma antigen,family A,member 6,expressed in melanoma,testis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
         
    MAGEA6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MAGEA6:
     Decreased melanin production 

    Animal Models:
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    miRTarBase miRNAs that target MAGEA6:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for MAGEA6 (P433601, 3 ENSP000003291994) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000137313Q128993I2D: score=1 
    ENSG00000226060Q128993I2D: score=1 
    ENSG00000228881Q128993I2D: score=1 
    ENSG00000230230Q128993I2D: score=1 
    ENSG00000231002Q128993I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    MAGEA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAGEA6 (MAGA6)

    Search CenterWatch for drugs/clinical trials and news about MAGEA6 / MAGA6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAGEA6 gene (2 alternative transcripts): 
    NM_005363.2  NM_175868.1  

    Unigene Cluster for MAGEA6:

    Melanoma antigen family A, 6
    Hs.441113  [show with all ESTs]
    Unigene Representative Sequence: BX640600
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329342(uc004ffq.1 uc004ffr.1) ENST00000412733 ENST00000457643

    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEA6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEA6

    Additional mRNA sequence: 

    AK289437.1 BC041599.1 BC067731.1 BX640600.1 D32076.1 EU161101.1 U10339.1 

    8 DOTS entries:

    DT.208961  DT.91772022  DT.91861095  DT.100777809  DT.97795237  DT.100029589  DT.100699310  DT.100777807 

    24/183 AceView cDNA sequences (see all 183):

    BE279401 BG575302 BC000340 BM781931 BM479202 BM999965 AI222439 BM762699 
    BQ226610 NM_005362 NM_175743 BE795782 BE901056 AA905896 CA429655 CA441190 
    BC017389 BQ436888 CR594285 BC003408 CR541774 AW673548 BU622519 BM760598 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGEA6 expression in normal human tissues (normalized intensities)      MAGEA6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAGEA6 Expression
    About this image


    MAGEA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             ES03(HES-3)
     
     Testis (Reproductive System)

     -- (Integumentary System)
             skin   

    See MAGEA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAGEA6

    SOURCE GeneReport for Unigene cluster: Hs.441113

    UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360
    Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell
    carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes

        SABiosciences Custom PCR Arrays for MAGEA6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for MAGEA6 (if available)
    TreeFam Gene Tree for MAGEA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGEA6 gene
    MAGEA31 2  MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEB42  MAGEC12  
    MAGED42  MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGED12  
    MAGEA22  MAGEB22  NDN2  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  MAGEA102  
    MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  MAGEA112  NDNL22  MAGEF12  
    18/38 SIMAP similar genes for MAGEA6 using alignment to 5 protein entries:     MAGA6_HUMAN (see all proteins) (see all similar genes):
    MAGEA3    MAGEA12    MAGEA2B    MAGEA2    MAGEA5    MAGEA4
    MAGEA8    MAGEA9B    MAGEA9    MAGEA1    MAGEA11    MAGEC4
    MAGEC3    MAGEH1    MAGEA13P    TRO    MAGEC1    MAGEB5

    MAGEA6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MAGEA6
    PGOHUM00000241601


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/76 SNPs in MAGEA6 are shown (see all 76)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998042841,2
    C--151865347(+) AGGGG-/AAAAAA 2 -- us2k10--------
    rs2015308551,2
    --151865980(+) TGAAA-/TTACAT 2 -- us2k10--------
    rs1444813821,2
    C,F--151869488(+) CACCAG/CATCCT 4 /H /D mis11Minor allele frequency- C:0.00NA 3032
    rs1496738971,2
    C--151869619(+) GAGTCC/TAGTTC 4 S syn10--------
    rs1426349541,2
    --151869647(+) GGAAGG/TTGGCC 4 V L mis10--------
    rs1505573421,2
    C,F--151869653(+) TGGCCA/GAGTTG 4 K E mis11Minor allele frequency- G:0.00NA 4542
    rs1406607901,2
    C,F--151869684(+) GTATCG/AAGCCA 4 /Q /R mis11Minor allele frequency- A:0.00NA 4552
    rs1478796391,2
    C--151869718(+) ATGCTG/AGGGAG 4 /L syn11Minor allele frequency- A:0.00NA 4552
    rs1414939431,2
    F--151869727(+) AGTGTC/TGTCGG 4 V syn11Minor allele frequency- T:0.00NA 4552
    rs1500148781,2
    C,F--151869731(+) TCGTCG/AGAAAT 4 /R /G mis11Minor allele frequency- A:0.00NA 4552

    HapMap Linkage Disequilibrium report for MAGEA6 (151867214 - 151870825 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAGEA6: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MAGEA6
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGEA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300176    OMIM disorders: --

    8 diseases for MAGEA6:    About MalaCards
    terminal osseous dysplasia    oral squamous cell carcinoma    dyskeratosis congenita    melanoma
    renal cell carcinoma    squamous cell carcinoma    gastric cancer    lung cancer

    1 disease from the University of Copenhagen DISEASES database for MAGEA6:
    Melanoma

    MAGEA6 for disorders           About GeneDecksing


    Export disorders for MAGEA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGEA6 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with MAGEA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MAGE-RING protein complexes comprise a family of E3 u biquitin ligases. (PubMed id 20864041)1, 2 Doyle J.M....Potts P.R. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
    4. Sequence analysis of the MAGE gene family encoding human tumor- rejection antigens. (PubMed id 7642112)1, 2 Imai Y.... Itoh K. (1995)
    5. Cloning and analysis of MAGE-1-related genes. (PubMed id 8037761)1, 2 Ding M.... Fenton R.G. (1994)
    6. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (1994)
    7. MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma. (PubMed id 12631591)1, 9 Tatsumi T....Storkus W.J. (2003)
    8. MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation anal ysis in induced sputum from patients with lung cancer and non-malignant lung dis eases. (PubMed id 22134685)1 Shin K.C....Jeon C.H. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Identification of novel MAGE-A6- and MAGE-A12-derived HLA-A24-restricted cytotoxic T lymphocyte epitopes using an in silico peptide-do cking assay. (PubMed id 22707303)1 Akiyama Y....Yamaguchi K. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4105 HGNC: 6804 AceView: MAGEA2andMAGEA3andMAGEA12 Ensembl:ENSG00000197172 euGenes: HUgn4105
    ECgene: MAGEA6 H-InvDB: MAGEA6

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for MAGEA6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEA6 Genetics and Cytogenetics in Oncology and Haematology

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    Patent Information for MAGEA6 gene:
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