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MAGEA6 Gene

protein-coding GIFtS: 49

GC0XP151617

melanoma antigen family A, 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MAGE6)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CT1.6 ^¹, ², ³
MAGE-3b ^²
MAGE3B ^²
MAGE6 ^², ³, ⁵
MGC52297 ^²
OTTHUMP00000024223 ^²

Descriptions
Cancer/testis antigen 1.6 ^³
MAGE-6 antigen ^², ³
MAGE3B antigen ^³
cancer/testis antigen family 1, member 6 ^²
melanoma antigen family A, 6 ^²
melanoma-associated antigen 6 ^²

External Ids
HGNC: 6804¹
Entrez Gene: 4105²
UniProtKB: P43360³
Ensembl: ENSG00000221867⁷

Search outside databases for aliases for MAGEA6 gene

Previous GC identifers: GC0XU990097 GC0XP148524 GC0XP149615 GC0XM150553 GC0XP150484 GC0XP151537

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAGEA6:

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50

to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show

considerable variability, suggesting that the existence of this gene family enables the same

function to be expressed under different transcriptional controls. The MAGEA genes are clustered

at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as

dyskeratosis congenita. Two transcript variants encoding the same protein have been identified for

this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360

Function: Not known, though may play a role in tumor or aspects of tumor progression

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAGEA6 gene

Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28

MAGEA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP151617: (about GC identifiers)

Start:	151,617,901 bp from pter
End:	151,621,480 bp from pter
Size:	3,580 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011726.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360 (See protein sequence)

Recommended Name: Melanoma-associated antigen 6

Size: 314 amino acids; 34891 Da

Secondary accessions: Q6NW44

REFSEQ proteins (2 alternative transcripts):

NP_005354.1 NP_787064.1

ENSEMBL proteins:

ENSP00000377480 ENSP00000329199 ENSP00000377478

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MAGEA6)
	Human Recombinant Proteins from Abnova (MAGEA6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

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Antibodies for MAGEA6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (MAGEA6), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAGEA6)
	Search Novus for antibodies for MAGEA6

Assays for MAGEA6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P43360

ProtoNet protein and cluster: P43360

1 Blocks protein family: IPB002190 MAGE protein

UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360

Similarity: Contains 1 MAGE domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005363

Applied Biosystems Silencer® siRNAs for MAGEA6

Sigma-Aldrich siRNA for MAGEA6

Sigma-Aldrich shRNA for MAGEA6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MAGEA6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005363
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005363
untagged cDNA clones in CMV expression vector (see all 2): NM_005363

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005363

UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360

Function: Not known, though may play a role in tumor or aspects of tumor progression

Genatlas biochemistry entry for MAGEA6:

human melanoma antigen,family A,member 6,expressed in melanoma,testis

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/10 Interacting proteins for MAGEA6 (P43360¹) via UniProtKB, MINT, and/or STRING (see all 10 )
Interactant Interaction Details
GeneCard External ID(s)
DDOST P39656¹ EBI-1045155, EBI-358866
EIF4G1 Q04637¹ EBI-1045155, EBI-73711
EIF4G2 P78344¹ EBI-1045155, EBI-296519
HDLBP Q00341¹ EBI-1045155, EBI-1049478
HEATR2 Q86Y56¹ EBI-1045155, EBI-719966
About this table
1 Gene Ontology (GO) biological process term (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGEA6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005363

Sigma-Aldrich siRNA for MAGEA6

Sigma-Aldrich shRNA for MAGEA6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005363 NM_175868

REFSEQ mRNAs for MAGEA6 gene (2 alternative transcripts):

NM_005363.2 NM_175868.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_175868

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_005363
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_005363
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005363

Additional cDNA sequence:

AK289437.1 BC041599.1 BC067731.1 BX640600.1 CR595748.1 CR611124.1 D32076.1 EU161101.1

U10339.1

8 DOTS entries:

DT.208961 DT.91772022 DT.91861095 DT.100777809 DT.97795237 DT.100029589 DT.100699310 DT.100777807

24/183 AceView cDNA sequences (see all 183 ):

CB145878 BM999965 NM_005362 BX106621 AW673548 CA441190 BM846958 AA905896

BM760598 BC005963 BI090658 BC017389 CR594285 BF791772 BC063681 BU622519

CA429655 NM_175743 BM015882 CR541774 BU182773 BM479202 BE795782 BC011744

highest scoring ESTs for MAGEA6:

AA995045 AL562721 BC041599 BC067731 BE207491 BE615120 BF792356 BG030104 BG254589 BG397171

Unigene Cluster for MAGEA6:

Melanoma antigen family A, 6

Hs.441113 [show with all ESTs]

Unigene Representative Sequence: BX640600

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000393902 ENST00000329342 ENST00000393900

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAGEA6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAGEA6

¹ / ² / ³

6 probe-sets matching MAGEA6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31599_f_at²^{, 3}	U95-A	10	1.00	0.32	1.00	1.00	U10691	0.20	0.50	0.38	1
33517_f_at²^{, 3}	U95-A	10	1.00	0.28	-0.28	1.06	U03735	0.20	0.50	0.38	1
209942_x_at²^{, 3}	U133-A	9	1.00	0.40	--	--	BC000340	0.40	0.38	0.39	2
214612_x_at²^{, 3}	U133-A	10	1.00	0.36	--	--	U10691	0.20	0.50	0.38	1
209942_x_at²	U133Plus2	9	1.00	0.40	--	--	--	--	--	--	--
214612_x_at²	U133Plus2	10	1.00	0.36	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.441113
Expression variation in blood from EXPOLDB for MAGEA6
UniProtKB/Swiss-Prot: MAGA6_HUMAN, P43360
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck
squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for
testes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

ENSEMBL Gene Tree for MAGEA6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAGEA6 gene

MAGEA3¹ ² MAGEA2B² MAGEA8² MAGEA12² MAGEA9² MAGEA9B² MAGEA4² MAGEA11²

MAGEA1² MAGEA10² MAGEA2²

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

5 NCBI SNPs in MAGEA6 are shown

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs7056365^1,2	A,C,F,H	151620421(+)	`CTTCAG/TCAAAG`	2	S/I	mis¹		3		EA WA	290
--	rs7057497^1,2	A,C	151620401(+)	`CAGTAC/TTTCTT`	2	Y/Y	syn¹		0	--	--	--	--
--	rs12846936^1,2	H	151620776(+)	`TATGAG/ATTCCT`	2	E/E	syn¹		4		EU EA WA	416
--	rs35823109^1,2	--	151620983(+)	`CATCCC/GTTAGT`	2	--	ut3¹		0	--	--	--	--
--	rs4007794^1,2	--	151616121(-)	`TTTTT-/TTTACCNA`	2	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for MAGEA6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300176

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/12 PubMed articles for MAGEA6 gene (see all 12 ):

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)^{2, 3} Rogner U.C....Poustka A. (1995)
Sequence analysis of the MAGE gene family encoding human tumor- rejection antigens. (PubMed id 7642112)^{3, 4} Imai Y.... Itoh K. (1995)
Cloning and analysis of MAGE-1-related genes. (PubMed id 8037761)^{3, 4} Ding M.... Fenton R.G. (1994)
Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)^{3, 4} De Plaen E.... Boon T. (1994)
MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma. (PubMed id 12631591)^{1, 3} Tatsumi T....Storkus W.J. (2003)
Expression of melanoma-associated antigens in oral squamous cell carcinoma. (PubMed id 18197853)³ Ries J....Nkenke E. (2008)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma. (PubMed id 12208877)³ Tatsumi T....Storkus W.J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4105	HGNC: 6804	AceView: MAGEA2andMAGEA3andMAGEA12	Ensembl:ENSG00000221867	euGenes: HUgn4105
ECgene: MAGEA6	H-InvDB: MAGEA6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MAGEA6	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MAGEA6
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MAGEA6:

TaqMan ® Gene Expression Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAGEA6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAGEA6		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MAGEA6		Browse small molecules at Sigma-Aldrich
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	Recombinant & Natural Proteins

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MAGEA6 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for MAGEA6

Summaries
for MAGEA6

Genomic Location
for MAGEA6

Proteins
for MAGEA6

Protein Domains/
Families
for MAGEA6

Gene Function
for MAGEA6

Pathways & Interactions
for MAGEA6

Drugs & Compounds
for MAGEA6

Transcripts
for MAGEA6

Expression
for MAGEA6

Orthologs
for MAGEA6

Paralogs
for MAGEA6

SNPs/Variants
for MAGEA6

Disorders & Mutations
for MAGEA6

Medical News
for MAGEA6

Publications
for MAGEA6

Search for MAGEA6

Genome Databases showing MAGEA6

Other Databases showing MAGEA6

Specialized Databases showing MAGEA6

Licensable Technologies
for MAGEA6

Services
for MAGEA6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAGEA6 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor MAGEA6

Summariesfor MAGEA6

Genomic Locationfor MAGEA6

Proteinsfor MAGEA6

Protein Domains/Familiesfor MAGEA6

Gene Functionfor MAGEA6

Pathways & Interactionsfor MAGEA6

Drugs & Compoundsfor MAGEA6

Transcriptsfor MAGEA6

Expression for MAGEA6

Orthologsfor MAGEA6

Paralogsfor MAGEA6

SNPs/Variantsfor MAGEA6

Disorders & Mutationsfor MAGEA6

Medical Newsfor MAGEA6

Publicationsfor MAGEA6

Search for MAGEA6

Genome Databases showing MAGEA6

Other Databases showing MAGEA6

Specialized Databases showing MAGEA6

Licensable Technologiesfor MAGEA6

Servicesfor MAGEA6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAGEA6

Summaries
for MAGEA6

Genomic Location
for MAGEA6

Proteins
for MAGEA6

Protein Domains/
Families
for MAGEA6

Gene Function
for MAGEA6

Pathways & Interactions
for MAGEA6

Drugs & Compounds
for MAGEA6

Transcripts
for MAGEA6

Expression
for MAGEA6

Orthologs
for MAGEA6

Paralogs
for MAGEA6

SNPs/Variants
for MAGEA6

Disorders & Mutations
for MAGEA6

Medical News
for MAGEA6

Publications
for MAGEA6

Licensable Technologies
for MAGEA6

Services
for MAGEA6