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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGEA5 Gene

protein-coding   GIFtS: 44
GCID: GC0XM151282

Melanoma Antigen Family A, 5


(Previous symbol: MAGE5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Melanoma Antigen Family A, 51 2     MAGE-5 Antigen2 3
MAGE51 2 3 5     Cancer/Testis Antigen Family 11
MAGE-5a Antigen1 2     Member 51
MAGE-5b Antigen1 2     MAGEA42
Cancer/Testis Antigen 1.52 3     Cancer/Testis Antigen Family 1, Member 52
CT1.52 3     Melanoma-Associated Antigen 52

External Ids:    HGNC: 68031   Entrez Gene: 41042   Ensembl: ENSG000002425207   OMIM: 3003405   UniProtKB: P433593   

Export aliases for MAGEA5 gene to outside databases

Previous GC identifers: GC0XM145618 GC0XM147941 GC0XM149030 GC0XM149900 GC0XM150953 GC0XM151033 GC0XM140136


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAGEA5 Gene:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence
identity to each other. The promoters and first exons of the MAGEA genes show considerable variability,
suggesting that the existence of this gene family enables the same function to be expressed under different
transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated
in some hereditary disorders, such as dyskeratosis congenita. This MAGEA gene encodes a protein that is
C-terminally truncated compared to other family members, and this gene can be alternatively interpreted to be a
pseudogene. The protein is represented in this Gene record in accordance with the assumed protein-coding status
defined in the literature. Read-through transcription exists between this gene and the upstream melanoma antigen
family A, 10 (MAGEA10) gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for MAGEA5 Gene: 
MAGEA5 (melanoma antigen family A, 5) is a protein-coding gene. Diseases associated with MAGEA5 include oral squamous cell carcinoma, and dyskeratosis congenita. An important paralog of this gene is MAGEA10-MAGEA5.

UniProtKB/Swiss-Prot: MAGA5_HUMAN, P43359
Function: Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability
in melanoma cell lines




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGEA5 gene promoter:
         AhR   GR   MEF-2A   Nkx6-1   FOXJ2 (long isoform)   FOXJ2   aMEF-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGEA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAGEA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MAGEA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEA5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM151282:  view genomic region     (about GC identifiers)

Start:
151,282,526 bp from pter      End:
151,286,444 bp from pter
Size:
3,919 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAGA5_HUMAN, P43359 (See protein sequence)
Recommended Name: Melanoma-associated antigen 5  
Size: 124 amino acids; 13016 Da
Secondary accessions: Q32MD0

Explore the universe of human proteins at neXtProt for MAGEA5: NX_P43359

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P43359

  • MAGEA5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_066387.1  
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry P43359

    ProtoNet protein and cluster: P43359

    UniProtKB/Swiss-Prot: MAGA5_HUMAN, P43359
    Similarity: Contains 1 MAGE domain


    MAGEA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAGA5_HUMAN, P43359
    Function: Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability
    in melanoma cell lines

         Genatlas biochemistry entry for MAGEA5:
    human melanoma antigen,family A,member 5,expressed in melanoma,testis

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEA5

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MAGEA5 (MAGA5)

    Search CenterWatch for drugs/clinical trials and news about MAGEA5 / MAGA5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAGEA5 gene: 
    NM_021049.4  

    Unigene Cluster for MAGEA5:

    Melanoma antigen family A, 5
    Hs.668021
    Unigene Representative Sequence: NM_021049
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446757 ENST00000427663(uc004ffj.3 uc022cgy.1)
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    Additional mRNA sequence: BC109187.1 

    1 DOTS entry:

    DT.95103326 

    24/48 AceView cDNA sequences (see all 48):

    BX335540 BX109673 BQ217649 BE277360 CB158974 BG477105 BG477980 AI142010 
    CR622868 BG477436 AY531264 BU167137 NM_021048 BX335541 BG478456 BM458898 
    BG282169 BE730450 CD109866 AY310324 R23725 AI200443 BG478664 NM_021049 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGEA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAGEA5 Expression
    About this image


    Genevestigator expression for MAGEA5

    SOURCE GeneReport for Unigene cluster: Hs.668021

    UniProtKB/Swiss-Prot: MAGA5_HUMAN, P43359
    Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell
    carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for MAGEA5 (if available)
    TreeFam Gene Tree for MAGEA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGEA5 gene
    MAGEA10-MAGEA5  
    16 SIMAP similar genes for MAGEA5 using alignment to 1 protein entry:     MAGA5_HUMAN:
    MAGEA12    MAGEA2B    MAGEA2    MAGEA4    MAGEA3    MAGEA6
    MAGEA1    MAGEA8    MAGEA11    MAGEA9B    MAGEA9    MAGEA13P
    MAGEB16    MAGEA10    MAGEC2    MAGEE1

    MAGEA5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/136 SNPs in MAGEA5 are shown (see all 136)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397093481,2
    --151148530(+) TGATGA/CGTGTC 1 -- ds50010--------
    rs1828954781,2
    --151148566(+) CAACAA/GCACTG 1 -- ds50010--------
    rs1876472471,2
    --151148580(+) CTAAAA/GCACAA 1 -- ds50010--------
    rs59251201,2
    C--151148674(+) CACACC/TCTCTG 1 -- ds50014Minor allele frequency- T:0.00NA 6
    rs736390611,2
    C--151148712(+) CCCCCC/GCCGAT 1 -- ds50011Minor allele frequency- G:0.00WA 2
    rs2110581,2
    C,F,H--151148862(+) GGGCAT/CCTCTC 1 -- ds500114Minor allele frequency- C:0.02NS EA WA NA CSA 1099
    rs1920231261,2
    --151148911(+) CCCTGG/TGGGTA 1 -- ds50010--------
    rs24719781,2
    C,A--151149090(+) TTTTTA/TAAAAA 1 -- ut311Minor allele frequency- T:0.00NA 2
    rs2105711,2
    C,F,H--151149108(+) ACCGAA/GTAGAC 1 -- ut3111Minor allele frequency- G:0.01NS EA WA NA CSA 418
    rs1875343101,2
    --151149139(+) AATATC/TTTTTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MAGEA5 (151282526 - 151286444 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MAGEA5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv520971CNV Gain19592680


    Locus Specific Mutation Databases (LSDB): MAGEA5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300340    OMIM disorders: --

    5 diseases for MAGEA5:    About MalaCards
    oral squamous cell carcinoma    dyskeratosis congenita    melanoma    squamous cell carcinoma
    lung cancer


    MAGEA5 for disorders           About GeneDecksing


    Export disorders for MAGEA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGEA5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MAGEA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
    3. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (1994)
    4. MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation anal ysis in induced sputum from patients with lung cancer and non-malignant lung dis eases. (PubMed id 22134685)1 Shin K.C....Jeon C.H. (2012)
    5. Expression of melanoma-associated antigens in oral squamous cell carcinoma. (PubMed id 18197853)1 Ries J....Nkenke E. (2008)
    6. MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines. (PubMed id 17942928)2 Yang B.... Longley B.J. (2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries. (PubMed id 10521804)1 Serrano A....Boon T. (1999)
    9. Proapoptotic signaling induced by RIG-I and MDA-5 res ults in type I interferon-independent apoptosis in human melanoma cells. (PubMed id 19620789)9 Besch R....Hartmann G. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4104 HGNC: 6803 AceView: MAGEA10andMAGEA5 Ensembl:ENSG00000242520 euGenes: HUgn4104
    ECgene: MAGEA5 H-InvDB: MAGEA5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAGEA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEA5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAGEA5 gene:
    Search GeneIP for patents involving MAGEA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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