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Aliases for MAGEA5 Gene

Aliases for MAGEA5 Gene

  • Melanoma Antigen Family A5 2 3
  • MAGE5 3 4 6
  • Cancer/Testis Antigen 1.5 3 4
  • MAGE-5a Antigen 2 3
  • MAGE-5b Antigen 2 3
  • MAGE-5 Antigen 3 4
  • CT1.5 3 4
  • Cancer/Testis Antigen Family 1, Member 5 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma-Associated Antigen 5 3
  • Melanoma Antigen Family A, 5 3
  • Member 5 2
  • MAGEA4 3

External Ids for MAGEA5 Gene

Previous HGNC Symbols for MAGEA5 Gene

  • MAGE5

Previous GeneCards Identifiers for MAGEA5 Gene

  • GC0XM145618
  • GC0XM147941
  • GC0XM149030
  • GC0XM149900
  • GC0XM150953
  • GC0XM151033
  • GC0XM151282
  • GC0XM140136

Summaries for MAGEA5 Gene

Entrez Gene Summary for MAGEA5 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This MAGEA gene encodes a protein that is C-terminally truncated compared to other family members, and this gene can be alternatively interpreted to be a pseudogene. The protein is represented in this Gene record in accordance with the assumed protein-coding status defined in the literature. Read-through transcription exists between this gene and the upstream melanoma antigen family A, 10 (MAGEA10) gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for MAGEA5 Gene

MAGEA5 (Melanoma Antigen Family A5) is a Protein Coding gene. Diseases associated with MAGEA5 include dyskeratosis congenita and oral squamous cell carcinoma. An important paralog of this gene is MAGEA10-MAGEA5.

UniProtKB/Swiss-Prot for MAGEA5 Gene

  • Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA5 Gene

Genomics for MAGEA5 Gene

Regulatory Elements for MAGEA5 Gene

Genomic Location for MAGEA5 Gene

152,114,049 bp from pter
152,117,939 bp from pter
3,891 bases
Minus strand

Genomic View for MAGEA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA5 Gene

Proteins for MAGEA5 Gene

  • Protein details for MAGEA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen 5
    Protein Accession:
    Secondary Accessions:
    • Q32MD0

    Protein attributes for MAGEA5 Gene

    124 amino acids
    Molecular mass:
    13016 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEA5 Gene

Proteomics data for MAGEA5 Gene at MOPED

Post-translational modifications for MAGEA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEA5 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for MAGEA5 Gene

Domains for MAGEA5 Gene

Protein Domains for MAGEA5 Gene

Suggested Antigen Peptide Sequences for MAGEA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P43359
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEA5: view

No data available for Gene Families for MAGEA5 Gene

Function for MAGEA5 Gene

Molecular function for MAGEA5 Gene

GENATLAS Biochemistry: human melanoma antigen,family A,member 5,expressed in melanoma,testis
UniProtKB/Swiss-Prot Function: Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.

Gene Ontology (GO) - Molecular Function for MAGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MAGEA5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MAGEA5 Gene

Localization for MAGEA5 Gene

Gene Ontology (GO) - Cellular Components for MAGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAGEA5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MAGEA5 Gene

Pathways for MAGEA5 Gene

SuperPathways for MAGEA5 Gene

No Data Available

Interacting Proteins for MAGEA5 Gene

Gene Ontology (GO) - Biological Process for MAGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEA5: view

No data available for Pathways by source for MAGEA5 Gene

Transcripts for MAGEA5 Gene

mRNA/cDNA for MAGEA5 Gene

(48) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEA5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MAGEA5
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA5 Gene

No ASD Table

Relevant External Links for MAGEA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEA5 Gene

mRNA expression in normal human tissues for MAGEA5 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MAGEA5 Gene

SOURCE GeneReport for Unigene cluster for MAGEA5 Gene Hs.668021

mRNA Expression by UniProt/SwissProt for MAGEA5 Gene

Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes
genes like me logo Genes that share expressions with MAGEA5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAGEA5 Gene

Orthologs for MAGEA5 Gene

Evolution for MAGEA5 Gene

Gene Tree for MAGEA5 (if available)
Gene Tree for MAGEA5 (if available)

No data available for Orthologs for MAGEA5 Gene

Paralogs for MAGEA5 Gene

Paralogs for MAGEA5 Gene

Selected SIMAP similar genes for MAGEA5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAGEA5: view

Variants for MAGEA5 Gene

Sequence variations from dbSNP and Humsavar for MAGEA5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_053492 -

Structural Variations from Database of Genomic Variants (DGV) for MAGEA5 Gene

Variant ID Type Subtype PubMed ID
nsv520971 CNV Gain 19592680

Relevant External Links for MAGEA5 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA5 Gene

Disorders for MAGEA5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MAGEA5 Gene including...

Search for MAGEA5 Gene in MalaCards »
genes like me logo Genes that share disorders with MAGEA5: view

No data available for UniProtKB/Swiss-Prot for MAGEA5 Gene

Publications for MAGEA5 Gene

  1. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PMID: 7927540) De Plaen E. … Boon T. (Immunogenetics 1994) 3 4
  2. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner U.C. … Poustka A. (Genomics 1995) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Expression of melanoma-associated antigens in oral squamous cell carcinoma. (PMID: 18197853) Ries J. … Nkenke E. (J. Oral Pathol. Med. 2008) 3
  5. MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation analysis in induced sputum from patients with lung cancer and non-malignant lung diseases. (PMID: 22134685) Shin K.C. … Jeon C.H. (Oncol. Rep. 2012) 3

Products for MAGEA5 Gene

Sources for MAGEA5 Gene

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