MAGEA5 Gene
protein-coding GIFtS: 44
GCID: GC0XM151282
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melanoma antigen family A, 5
(Previous symbol: MAGE5)
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Aliases
for MAGEA5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| Melanoma Antigen Family A, 51 2 | | MAGEA42 | | MAGE51 2 3 5 | | Cancer/Testis Antigen Family 1, Member 52 | | CT1.51 2 3 | | MAGE-5a Antigen2 | | Cancer/Testis Antigen 1.52 3 | | MAGE-5b Antigen2 | | MAGE-5 Antigen2 3 | | Melanoma-Associated Antigen 52 | | MGC1295261 | | |
Export aliases for MAGEA5 gene to outside databasesPrevious GC identifers: GC0XM145618 GC0XM147941 GC0XM149030 GC0XM149900 GC0XM150953 GC0XM151033 GC0XM140136 |
Summaries
for MAGEA5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEA5:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequenceidentity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggestingthat the existence of this gene family enables the same function to be expressed under different transcriptionalcontrols. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditarydisorders, such as dyskeratosis congenita. This MAGEA gene encodes a protein that is C-terminally truncated comparedto other family members, and this gene can be alternatively interpreted to be a pseudogene. The protein is representedin this Gene record in accordance with the assumed protein-coding status defined in the literature. Read-throughtranscription exists between this gene and the upstream melanoma antigen family A, 10 (MAGEA10) gene. (provided byRefSeq, Oct 2011)
UniProtKB/Swiss-Prot: MAGA5_HUMAN, P43359Function: Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability inmelanoma cell lines
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Genomic Views
for MAGEA5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEA5 gene promoter:
AhR GR MEF-2A Nkx6-1 FOXJ2 (long isoform) FOXJ2 aMEF-2 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEA5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28MAGEA5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM151282: view genomic region
(about GC identifiers)
Start:
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151,282,526 bp from pter |
End:
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151,286,444 bp from pter |
Size:
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3,919 bases |
Orientation:
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minus strand |
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Proteins
for MAGEA5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGA5_HUMAN, P43359 (See
protein sequence)Recommended Name: Melanoma-associated antigen 5 Size: 124 amino acids; 13016 Da
Secondary accessions: Q32MD0Explore the universe of human proteins at neXtProt for MAGEA5: NX_P43359
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P43359
MAGEA5 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_066387.1
Human Recombinant Protein Products:
MAGEA5 Antibody Products:
Assay Products for MAGEA5: |
Protein
Domains /
Families
for MAGEA5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEA5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P43359ProtoNet protein and cluster: P43359 UniProtKB/Swiss-Prot: MAGA5_HUMAN, P43359Similarity: Contains 1 MAGE domain |
Function
for MAGEA5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: MAGA5_HUMAN, P43359Function: Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability inmelanoma cell lines Genatlas biochemistry entry for MAGEA5:human melanoma antigen,family A,member 5,expressed in melanoma,testis
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA5 |
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Pathways & Interactions
for MAGEA5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEA5
|
Drugs & Compounds
for MAGEA5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEA5
Search CenterWatch for drugs/clinical trials and news about MAGEA5 / MAGA5
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Transcripts
for MAGEA5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEA5 gene: NM_021049.4 Unigene Cluster for MAGEA5: Melanoma antigen family A, 5 Hs.668021 Unigene Representative Sequence: NM_0210492 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000446757 ENST00000427663(uc004ffj.3 uc022cgy.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAGEA5 (NM_021049) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEA5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEA5 |
Additional cDNA sequence: AY310324.1 BC109187.1 1 DOTS entry: DT.95103326 24/48 AceView cDNA sequences (see all 48): BX109673 AY531264 BG477105 BE277360 AI142010 BX335540 BG477436 CB158974 BQ217649 BG477980 CR622868 R23725 BX097006 BX335541 BE277068 CD109866 AY310324 AI200443 NM_021049 BE389926 BE730450 NM_021048 BG478664 BG478456
GeneLoc Exon Structure
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Expression
for MAGEA5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEA5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for MAGEA5
SOURCE GeneReport for Unigene cluster: Hs.668021
UniProtKB/Swiss-Prot: MAGA5_HUMAN, P43359Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma,lung carcinoma and breast carcinoma, but not in normal tissues except for testes
SABiosciences Custom PCR Arrays for MAGEA5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEA5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MAGEA5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEA5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEA5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA5 |
Orthologs
for MAGEA5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for MAGEA5 (if available)
TreeFam Gene Tree for MAGEA5 (if available) |
Paralogs
for MAGEA5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEA5 gene
- MAGEA10-MAGEA5
17 SIMAP similar genes for MAGEA5 using alignment to 1 protein entry: MAGA5_HUMAN:MAGEA12 MAGEA2B MAGEA2 MAGEA4 MAGEA3 MAGEA6
MAGEA1 MAGEA8 MAGEA11 MAGEA9B MAGEA9 MAGEA13P
MAGEB16 MAGEA10 MAGEC2 MAGEE1 MAGEC3
MAGEA5 for paralogs About GeneDecksing
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Genomic Variants
for MAGEA5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEA5 (151282526 - 151286444 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAGEA5
1 CNV: 52961
Locus Specific Mutation Databases (LSDB): MAGEA5
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MAGEA5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEA5 for disorders About GeneDecksing
OMIM gene information: 300340
OMIM disorders: --
8  diseases for MAGEA5: About MalaCardsdyskeratosis congenita melanoma dyskeratosis oral squamous cell carcinoma
squamous cell carcinoma lung carcinoma carcinoma breast carcinoma
Export disorders for MAGEA5 gene to outside databases
|
Publications
for MAGEA5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEA5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAGEA5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
- Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (1994)
- MAGE A1-A6 RT-PCR and MAGE A3 and p16 methylation anal ysis in induced sputum from patients with lung cancer and non-malignant lung dis eases. (PubMed id 22134685)1 Shin K.C....Jeon C.H. (2012)
- Expression of melanoma-associated antigens in oral squamous cell carcinoma. (PubMed id 18197853)1 Ries J....Nkenke E. (2008)
- MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines. (PubMed id 17942928)2 Yang B.... Longley B.J. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries. (PubMed id 10521804)1 Serrano A....Boon T. (1999)
- Proapoptotic signaling induced by RIG-I and MDA-5 res ults in type I interferon-independent apoptosis in human melanoma cells. (PubMed id 19620789)9 Besch R....Hartmann G. (2009)
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External Searches for MAGEA5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MAGEA5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MAGEA5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEA5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
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About This Section
| Patent Information for MAGEA5 gene:
Search GeneIP for patents involving MAGEA5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEA5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| |  |  |  |  | | | | | | Recombinant Protein for MAGEA5 |
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 | | | MAGEA5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA5 |
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