Aliases for MAGEA5 Gene
External Ids for MAGEA5 Gene
Previous HGNC Symbols for MAGEA5 Gene
Previous GeneCards Identifiers for MAGEA5 Gene
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This MAGEA gene encodes a protein that is C-terminally truncated compared to other family members, and this gene can be alternatively interpreted to be a pseudogene. The protein is represented in this Gene record in accordance with the assumed protein-coding status defined in the literature. Read-through transcription exists between this gene and the upstream melanoma antigen family A, 10 (MAGEA10) gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for MAGEA5 Gene
MAGEA5 (Melanoma Antigen Family A5) is a Protein Coding gene. Diseases associated with MAGEA5 include dyskeratosis congenita and oral squamous cell carcinoma. An important paralog of this gene is MAGEA10-MAGEA5.
UniProtKB/Swiss-Prot for MAGEA5 Gene
Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.