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Aliases for MAGEA4 Gene

Aliases for MAGEA4 Gene

  • MAGE Family Member A4 2 3 5
  • Melanoma Antigen Family A4 2 3
  • Cancer/Testis Antigen 1.4 3 4
  • MAGE-41 Antigen 3 4
  • MAGE-X2 Antigen 3 4
  • MAGE-4 Antigen 3 4
  • MAGE4 3 4
  • CT1.4 3 4
  • Cancer/Testis Antigen Family 1, Member 4 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma-Associated Antigen 4 2
  • Melanoma Antigen Family A, 4 3
  • Member 4 2
  • MAGE-41 3
  • MAGE-X2 3
  • MAGE4A 3
  • MAGE4B 3

External Ids for MAGEA4 Gene

Previous HGNC Symbols for MAGEA4 Gene

  • MAGE4

Previous GeneCards Identifiers for MAGEA4 Gene

  • GC0XP145421
  • GC0XP147744
  • GC0XP148829
  • GC0XP149702
  • GC0XP149699
  • GC0XP150752
  • GC0XP150832
  • GC0XP151080
  • GC0XP139939

Summaries for MAGEA4 Gene

Entrez Gene Summary for MAGEA4 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA4 Gene

MAGEA4 (MAGE Family Member A4) is a Protein Coding gene. Diseases associated with MAGEA4 include Melanoma and Testicular Leukemia. An important paralog of this gene is MAGEC3.

UniProtKB/Swiss-Prot for MAGEA4 Gene

  • Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Gene Wiki entry for MAGEA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA4 Gene

Genomics for MAGEA4 Gene

Regulatory Elements for MAGEA4 Gene

Enhancers for MAGEA4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAGEA4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MAGEA4 gene promoter:

Genomic Location for MAGEA4 Gene

151,912,509 bp from pter
151,925,170 bp from pter
12,662 bases
Plus strand

Genomic View for MAGEA4 Gene

Genes around MAGEA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA4 Gene

Proteins for MAGEA4 Gene

  • Protein details for MAGEA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen 4
    Protein Accession:
    Secondary Accessions:
    • Q14798

    Protein attributes for MAGEA4 Gene

    317 amino acids
    Molecular mass:
    34899 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MAGEA4 Gene

neXtProt entry for MAGEA4 Gene

Proteomics data for MAGEA4 Gene at MOPED

Post-translational modifications for MAGEA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGEA4 Gene

Domains & Families for MAGEA4 Gene

Gene Families for MAGEA4 Gene

Protein Domains for MAGEA4 Gene


Suggested Antigen Peptide Sequences for MAGEA4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MAGE domain.
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEA4: view

Function for MAGEA4 Gene

Molecular function for MAGEA4 Gene

GENATLAS Biochemistry:
human melanoma antigen,family A,member 4,expressed in melanoma,testis and placenta
UniProtKB/Swiss-Prot Function:
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
genes like me logo Genes that share phenotypes with MAGEA4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEA4 Gene

Localization for MAGEA4 Gene

Subcellular locations from

Jensen Localization Image for MAGEA4 Gene COMPARTMENTS Subcellular localization image for MAGEA4 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEA4 Gene

Pathways & Interactions for MAGEA4 Gene

SuperPathways for MAGEA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEA4 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAGEA4 Gene

Drugs & Compounds for MAGEA4 Gene

No Compound Related Data Available

Transcripts for MAGEA4 Gene

Unigene Clusters for MAGEA4 Gene

Melanoma antigen family A, 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA4 Gene

No ASD Table

Relevant External Links for MAGEA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEA4 Gene

mRNA expression in normal human tissues for MAGEA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEA4 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for MAGEA4 Gene

This gene is overexpressed in Ovary (29.1), Lung (21.3), and Testis (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEA4 Gene

SOURCE GeneReport for Unigene cluster for MAGEA4 Gene Hs.37107

mRNA Expression by UniProt/SwissProt for MAGEA4 Gene

Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
genes like me logo Genes that share expression patterns with MAGEA4: view

Protein tissue co-expression partners for MAGEA4 Gene

Orthologs for MAGEA4 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAGEA4 35
  • 98.84 (n)
  • 97.16 (a)
  • 97 (a)
(Mus musculus)
Mammalia 1700080O16Rik 36
  • 40 (a)
3830417A13Rik 36
  • 38 (a)
Magea1 36
  • 38 (a)
Magea10 36
  • 42 (a)
Magea2 36
  • 38 (a)
Magea3 36
  • 39 (a)
Magea4 36
  • 38 (a)
Magea5 36
  • 39 (a)
Magea6 36
  • 40 (a)
Magea8 36
  • 39 (a)
Species with no ortholog for MAGEA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA4 Gene

Gene Tree for MAGEA4 (if available)
Gene Tree for MAGEA4 (if available)

Paralogs for MAGEA4 Gene Pseudogenes for MAGEA4 Gene

genes like me logo Genes that share paralogs with MAGEA4: view

Variants for MAGEA4 Gene

Sequence variations from dbSNP and Humsavar for MAGEA4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1047251 - 151,924,181(+) ACCCC(A/G)CCAGC reference, missense
VAR_036582 A breast cancer sample
rs747765671 -- 151,925,091(+) TAAAA(A/T)ATATA utr-variant-3-prime
rs747897935 -- 151,919,470(+) CCCAT(C/G)CACAC intron-variant, upstream-variant-2KB
rs747954097 -- 151,924,289(+) TGGGC(A/T)CAATT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAGEA4 Gene

Variant ID Type Subtype PubMed ID
nsv510866 CNV Loss 20534489
nsv528228 CNV Gain 19592680
esv2656900 CNV Deletion 23128226
esv22619 CNV Gain 19812545
esv1005324 CNV Deletion 20482838
esv2664390 CNV Deletion 23128226
esv2740611 CNV Deletion 23290073

Variation tolerance for MAGEA4 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEA4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA4 Gene

Disorders for MAGEA4 Gene

MalaCards: The human disease database

(10) MalaCards diseases for MAGEA4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
testicular leukemia
testicular cancer
  • childhood neoplasm of the testis
  • seminoma, pure
klinefelter's syndrome
  • hypogonadotropic hypogonadism
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEA4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAGEA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA4 Gene

Publications for MAGEA4 Gene

  1. High-resolution structure of HLA-A*0201 in complex with a tumour- specific antigenic peptide encoded by the MAGE-A4 gene. (PMID: 11502003) Hillig R.C. … Hulsmeyer M. (J. Mol. Biol. 2001) 3 4 23 67
  2. Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer. (PMID: 19545928) Shigematsu Y. … Yasumoto K. (Lung Cancer 2010) 3 23
  3. High frequency of MAGE-A4 and MAGE-A9 expression in high-risk bladder cancer. (PMID: 19533752) Bergeron A. … Fradet Y. (Int. J. Cancer 2009) 3 23
  4. Cancer/testis antigen MAGE-A4 expression pattern differs in epithelial skin tumors of organ-transplant recipients and immunocompetent patients. (PMID: 17214847) Muehleisen B. … Hofbauer G.F. (J. Cutan. Pathol. 2007) 3 23
  5. Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance. (PMID: 16596224) Yoshida N. … Nishimura T. (Int. J. Oncol. 2006) 3 23

Products for MAGEA4 Gene

Sources for MAGEA4 Gene