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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGEA4 Gene

protein-coding   GIFtS: 57
GCID: GC0XP151080

melanoma antigen family A, 4


(Previous symbol: MAGE4)
 Explore 52 diseases affiliated with
MAGEA4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAGEA4    

Aliases
for MAGEA4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Melanoma Antigen Family A, 41 2     Cancer/Testis Antigen 1.42 3
CT1.41 2 3     MAGE-4 Antigen2 3
MAGE41 2 3     MAGE-41 Antigen2 3
MAGE4A1 2 5     MAGE-X2 Antigen2 3
MAGE4B1 2 5     MGC213361
MAGE-411 2     Cancer/Testis Antigen Family 1, Member 42
MAGE-X21 2     Melanoma-Associated Antigen 42

External Ids:    HGNC: 68021   Entrez Gene: 41032   Ensembl: ENSG000001473817   OMIM: 3001755   UniProtKB: P433583   

Export aliases for MAGEA4 gene to outside databases

Previous GC identifers: GC0XP145421 GC0XP147744 GC0XP148829 GC0XP149702 GC0XP149699 GC0XP150752 GC0XP150832 GC0XP139939


Summaries
for MAGEA4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAGEA4:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence
identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting
that the existence of this gene family enables the same function to be expressed under different transcriptional
controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary
disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this
gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MAGA4_HUMAN, P43358
Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor
progression

Gene Wiki entry for MAGEA4


Genomic Views
for MAGEA4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGEA4 gene promoter:
         Elk-1   p53   Olf-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAGEA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAGEA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MAGEA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEA4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP151080:  view genomic region     (about GC identifiers)

Start:
 151,080,981 bp from pter      End:
 151,093,642 bp from pter
Size:
 12,662 bases      Orientation:
 plus strand

Proteins
for MAGEA4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAGA4_HUMAN, P43358 (See protein sequence)
Recommended Name: Melanoma-associated antigen 4  
Size: 317 amino acids; 34899 Da
2 PDB 3D structures from and Proteopedia for MAGEA4:
1I4F (3D)        2WA0 (3D)    
Secondary accessions: Q14798

Explore the universe of human proteins at neXtProt for MAGEA4: NX_P43358

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P43358

    • MAGEA4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001011548.1  NP_001011549.1  NP_001011550.1  NP_002353.3  

    ENSEMBL proteins: 
     ENSP00000387777   ENSP00000391904   ENSP00000394149   ENSP00000402624   ENSP00000359365  
     ENSP00000394073   ENSP00000400900   ENSP00000402186   ENSP00000359360   ENSP00000353379  
     ENSP00000390096   ENSP00000276344   ENSP00000377498   ENSP00000359362   ENSP00000377497  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--


    MAGEA4 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MAGEA4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAGEA4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry P43358

    ProtoNet protein and cluster: P43358

    1 Blocks protein family: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGA4_HUMAN, P43358
    Similarity: Contains 1 MAGE domain


    Function
    for MAGEA4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MAGA4_HUMAN, P43358
    Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor
    progression

         Genatlas biochemistry entry for MAGEA4:
    human melanoma antigen,family A,member 4,expressed in melanoma,testis and placenta

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI14739298


    MAGEA4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MAGEA4:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for MAGEA4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAGEA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for MAGEA4 (P433581, 2, 3 ENSP000002763444) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UQCRBP149272, 3, ENSP000002870224MINT-66319 I2D: score=5 STRING: ENSP00000287022
    TEKT4Q8WW242, 3, ENSP000002952014MINT-67802 I2D: score=4 STRING: ENSP00000295201
    HLA-AP304433, ENSP000003660054I2D: score=2 I2D: score=1 STRING: ENSP00000366005
    PSMD10O758321, 3, ENSP000002179584EBI-743122,EBI-752185 I2D: score=3 STRING: ENSP00000217958
    ZBTB17Q131051, 3, ENSP000003648954EBI-743122,EBI-372156 I2D: score=1 STRING: ENSP00000364895
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    MAGEA4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAGEA4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAGEA4
    Search CenterWatch for drugs/clinical trials and news about MAGEA4 / MAGA4 

    Transcripts
    for MAGEA4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAGEA4 gene (4 alternative transcripts): 
    NM_001011548.1  NM_001011549.1  NM_001011550.1  NM_002362.4  

    Unigene Cluster for MAGEA4:

    Melanoma antigen family A, 4
    Hs.37107  [show with all ESTs]
    Unigene Representative Sequence: BC017723
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431963 ENST00000448295 ENST00000430273 ENST00000441865 ENST00000370340
    ENST00000416020 ENST00000425182 ENST00000457310 ENST00000370335 ENST00000360243(uc004ffd.3)
    ENST00000431971 ENST00000276344(uc004ffa.3) ENST00000393921 ENST00000370337
    ENST00000393920(uc022cgu.1 uc004fez.3 uc004ffb.3 uc004ffc.3)


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    Additional cDNA sequence: 

    AK300179.1 AK313862.1 AY954624.1 BC017723.1 BC096712.1 D32075.1 D32077.1 U10340.1 

    2 DOTS entries:

    DT.309111  DT.97775458 

    24/69 AceView cDNA sequences (see all 69):

    CB123950 BM562465 CB120212 AI805352 CB123276 CR623041 BM556490 CR622709 
    AI863022 CB120460 CB121933 CB118648 D32077 AW103946 BG115115 AA857809 
    BM783686 BM909650 BM561507 BX479311 CB115479 BM479073 BM172347 BG024106 

    GeneLoc Exon Structure


    Expression
    for MAGEA4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGEA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAGEA4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryOvigerous CordOogoniaFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAGEA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAGEA4

    SOURCE GeneReport for Unigene cluster: Hs.37107

    UniProtKB/Swiss-Prot: MAGA4_HUMAN, P43358
    Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma,
    lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta

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    In Situ
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    Orthologs
    for MAGEA4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MAGEA4 gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 32(a)
    		 1 → many
    		 1(205669616-205678308)
    zebrafish
    (Danio rerio)    		 Actinopterygii ndnl26
    		 necdin-like 2
    		 25(a)
    		 1 → many
    		 23(13012414-13025121)
    fruit fly
    (Drosophila melanogaster)    		 Insecta MAGE6
    		 MAGE
    		 19(a)
    		 1 → many
    		 3R(2979960-2980898)


    ENSEMBL Gene Tree for MAGEA4 (if available)
    TreeFam Gene Tree for MAGEA4 (if available) 

    Paralogs
    for MAGEA4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGEA4 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB42  MAGEB12  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGEE12  
    MAGED12  MAGEA22  MAGEC32  MAGEA32  NDN2  MAGEB22  MAGEB32  MAGED4B2  
    MAGEE22  MAGEA12  MAGEA102  MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  
    MAGEA112  NDNL22  MAGEF12  
    18/39 SIMAP similar genes for MAGEA4 using alignment to 7 protein entries:     MAGA4_HUMAN (see all proteins) (see all similar genes):
    MAGEA5    MAGEA12    MAGEA1    MAGEA2B    MAGEA6    MAGEA2
    MAGEA8    MAGEA3    MAGEA9B    MAGEA11    MAGEH1    MAGEC4
    MAGEA9    MAGEB16    MAGEA13P    MAGEB5    MAGEC1    TRO

    MAGEA4 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MAGEA4
    PGOHUM00000260931 PGOHUM00000260998


    Genomic Variants
    for MAGEA4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/184 NCBI SNPs in MAGEA4 are shown (see all 184)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs126892751,2
    		C,H--139937598(+) GCTTAG/TTCCCT 3 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1127578421,2
    		C,--139937611(+) TGTCAT/GCCCTG 3 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1116842521,2
    		C,--139937892(+) TGACTC/TGCGCA 3 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs28563761,2
    		C--139939629(+) AATCCC/TGCACC 1 -- int10--------
    rs561448841,2
    		C--139939714(+) TCGCAG/TGGGAC 1 -- int10--------
    rs562995591,2
    		C--139940026(+) CGCTTC/TCAACC 1 -- int10--------
    rs560503411,2
    		C--139940149(+) GATGCC/TACTGA 1 -- int10--------
    rs23011921,2
    		C,F,A,H,--151079445(+) AGAACA/GTTGTA 3 -- us2k1 int114Minor allele frequency- G:0.40NS EA NA 1982
    rs1916516901,2
    		--151079534(+) TGCTGC/TTCTCT 3 -- nc-transcript-variantus2k10--------
    rs1838003641,2
    		--151079703(+) GAGGGA/GGGTTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAGEA4 (151080981 - 151093642 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for MAGEA4
         3 CNVs: 97092 83852 83853
    Locus Specific Mutation Databases (LSDB): MAGEA4

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MAGEA4

    Disorders / Diseases
    for MAGEA4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAGEA4 for disorders           About GeneDecksing

    OMIM gene information: 300175    OMIM disorders: --

    20/52 diseases for MAGEA4 (see all 52):    About MalaCards
    dyskeratosis congenita    dyskeratosis    non-small cell lung carcinoma    melanoma
    testicular germ cell tumor    non-hodgkin lymphoma    squamous cell carcinoma    chromophobe renal cell carcinoma
    germ cell tumor    liver cirrhosis    oral squamous cell carcinoma    renal oncocytoma
    esophageal squamous cell carcinoma    cervical squamous cell carcinoma    renal cell carcinoma    hodgkin's lymphoma
    carcinoma    transitional cell carcinoma    testicular cancer    klinefelter's syndrome

    1 disease from the University of Copenhagen DISEASES database for MAGEA4:
    Melanoma

    10/28 Novoseek disease relationships for MAGEA4 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testicular cancer 85.1 7 16467087 (2), 14991579 (1), 19207618 (1), 12875607 (1) (see all 6)
    uterine neoplasms 72.1 1 14695148 (1)
    melanoma 57.8 13 9618514 (1), 11502003 (1), 16845331 (1), 12209997 (1) (see all 9)
    tumors 52 60 11983123 (4), 14695148 (4), 10842198 (4), 11753951 (3) (see all 31)
    esophageal carcinoma 46.2 1 10540345 (1)
    cancer 46.1 15 16596224 (3), 10540345 (2), 9033629 (2), 16061876 (2) (see all 9)
    seminoma 42.8 13 11753951 (4), 12605640 (3), 17993720 (1)
    carcinoma 42.3 19 14695148 (4), 12209997 (3), 9033629 (2), 16151806 (2) (see all 11)
    hepatocellular carcinoma 38.5 6 9369941 (2), 11983123 (1), 12747756 (1), 18942708 (1) (see all 5)
    carcinoma non-small cell lung 34.8 3 16596224 (2), 16651421 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAGEA4 (1 document)

    Export disorders for MAGEA4 gene to outside databases

    Publications
    for MAGEA4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGEA4 gene, integrated from 9 sources (see all 106):
    (articles sorted by number of sources associating them with MAGEA4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. High-resolution structure of HLA-A*0201 in complex with a tumour- specific antigenic peptide encoded by the MAGE-A4 gene. (PubMed id 11502003)1, 2, 9 Hillig R.C....Hulsmeyer M. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Sequence analysis of the MAGE gene family encoding human tumor- rejection antigens. (PubMed id 7642112)1, 2 Imai Y.... Itoh K. (1995)
    4. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
    5. Cloning and analysis of MAGE-1-related genes. (PubMed id 8037761)1, 2 Ding M.... Fenton R.G. (1994)
    6. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (1994)
    7. A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells. (PubMed id 14739298)1, 9 Sakurai T.... Fujita J. (2004)
    8. Melanoma antigen A4 is expressed in non-small cell lung cancers and promotes apoptosis. (PubMed id 16651421)1, 9 Peikert T.... Comhair S.A. (2006)
    9. Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance. (PubMed id 16596224)1, 9 Yoshida N....Nishimura T. (2006)
    10. Clinical significance of cancer/testis antigens expre ssion in patients with non-small cell lung cancer. (PubMed id 19545928)1, 9 Shigematsu Y....Yasumoto K. (2010)

    External Searches for MAGEA4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing MAGEA4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4103 HGNC: 6802 AceView: MAGEA4 Ensembl:ENSG00000147381 euGenes: HUgn4103
    ECgene: MAGEA4 H-InvDB: MAGEA4

    Other Databases showing MAGEA4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAGEA4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAGEA4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEA4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAGEA4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAGEA4 gene:
    Search GeneIP for patents involving MAGEA4

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