Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGEA3 Gene

protein-coding   GIFtS: 55
GCID: GC0XM151934

melanoma antigen family A, 3


(Previous symbol: MAGE3)
 Explore 53 diseases affiliated with
MAGEA3 via our new
 Human Malady Compendium 
Biological research products
for MAGEA3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Melanoma Antigen Family A, 31 2     Cancer/Testis Antigen 1.32 3
MAGE31 2 3 5     MAGE-3 Antigen2 3
CT1.31 2 3     MGC146131
HIP81 2     MAGEA62
HYPD1 2     Cancer/Testis Antigen Family 1, Member 32
Antigen MZ2-D2 3     Melanoma-Associated Antigen 32

External Ids:    HGNC: 68011   Entrez Gene: 41022   Ensembl: ENSG000002218677   OMIM: 3001745   UniProtKB: P433573   

Export aliases for MAGEA3 gene to outside databases

Previous GC identifers: GC0XM146274 GC0XM148591 GC0XM149682 GC0XM150552 GC0XM151605 GC0XM151685 GC0XM140736


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAGEA3:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence
identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting
that the existence of this gene family enables the same function to be expressed under different transcriptional
controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary
disorders, such as dyskeratosis congenita. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MAGA3_HUMAN, P43357
Function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein
ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to
act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play
a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell
viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes

Gene Wiki entry for MAGEA3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGEA3 gene promoter:
         MEF-2A   p53   FOXJ2 (long isoform)   MEF-2   MyoD   FOXJ2   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MAGEA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MAGEA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEA3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM151934:  view genomic region     (about GC identifiers)

Start:
151,934,652 bp from pter      End:
151,938,240 bp from pter
Size:
3,589 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MAGA3_HUMAN, P43357 (See protein sequence)
Recommended Name: Melanoma-associated antigen 3  
Size: 314 amino acids; 34747 Da
Subunit: Interacts with TRIM28
Caution: In vitro experiments by PubMed:17942928 measuring cell viability in melanoma cell lines used siRNA specific
for MAGEA3 and MAGEA6
1 PDB 3D structure from and Proteopedia for MAGEA3:
1QEW (3D)    
Secondary accessions: Q6FHI6

Explore the universe of human proteins at neXtProt for MAGEA3: NX_P43357

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P43357

  • MAGEA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005353.1  
    ENSEMBL proteins: 
     ENSP00000359301   ENSP00000392758   ENSP00000377480  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MAGEA3
    OriGene Protein Over-expression Lysate: MAGEA3
    OriGene Custom Protein Services for MAGEA3 
    GenScript Custom Purified and Recombinant Proteins Services for MAGEA3
    Novus Biologicals MAGEA3 Proteins
    Novus Biologicals MAGEA3 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MAGEA3
    Uscn Proteins for MAGEA3


    MAGEA3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 10): MAGEA3
    OriGene Custom Antibody Services for MAGEA3 
    GenScript Custom Superior Antibodies Services for MAGEA3
    Novus Biologicals MAGEA3 Antibodies
    Search for Antibodies for MAGEA3 at Abcam  
    Uscn Antibodies for MAGEA3
    ThermoFisher Antibodies for MAGEA3

    Assay Products for MAGEA3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAGEA3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAGEA3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MAGEA3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry P43357

    ProtoNet protein and cluster: P43357

    1 Blocks protein family: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGA3_HUMAN, P43357
    Similarity: Contains 1 MAGE domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MAGA3_HUMAN, P43357
    Function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein
    ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to
    act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play
    a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell
    viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes

         Genatlas biochemistry entry for MAGEA3:
    human melanoma antigen,family A,member 3,expressed in melanoma,testis,advanced gastric carcinomas and hepatocellular
    carcinomas

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAGEA3:
    hsa-mir-34a (MIRT004111)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAGEA3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MAGEA3
    SwitchGear 3'UTR luciferase reporter plasmidMAGEA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAGEA3
    OriGene shRNA RFP: MAGEA3
    OriGene siRNA: MAGEA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAGEA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAGEA3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA3
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAGEA3 (NM_005362)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGEA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEA3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAGEA3
    Search LifeMap BioReagents cell lines for MAGEA3

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA3

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    MAGEA3 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEA3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MAGEA3 (P433571, 3 ENSP000003593014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428583, ENSP000003471844I2D: score=1 STRING: ENSP00000347184
    TRIM28Q132631, ENSP000002530244EBI-5651459,EBI-78139 STRING: ENSP00000253024
    SUMO2ENSP000004059654STRING: ENSP00000405965
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAGEA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAGEA3
    4 Novoseek chemical compound relationships for MAGEA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hemocyanin 53.5 2 10431688 (1), 11522640 (1)
    ethidium bromide 11.2 1 15570431 (1)
    paraffin 6.12 2 11776642 (1), 15100734 (1)
    oligonucleotide 0 1 15355897 (1)

    Search CenterWatch for drugs/clinical trials and news about MAGEA3 / MAGA3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAGEA3 gene: 
    NM_005362.3  

    Unigene Cluster for MAGEA3:

    Melanoma antigen family A, 3
    Hs.417816  [show with all ESTs]
    Unigene Representative Sequence: NM_005362
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370278(uc004fgp.3) ENST00000417212 ENST00000393902

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAGEA3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MAGEA3
    SwitchGear 3'UTR luciferase reporter plasmidMAGEA3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAGEA3
    OriGene shRNA RFP: MAGEA3
    OriGene siRNA: MAGEA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAGEA3
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA3
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAGEA3 (NM_005362)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAGEA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEA3 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEA3
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat MAGEA3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEA3

    Additional cDNA sequence: 

    AK223519.1 AK292384.1 BC000340.2 BC005963.1 BC011744.2 BC016803.1 BC017389.1 CR541767.1 
    CR541768.1 CR541774.1 CR542020.1 

    3 DOTS entries:

    DT.91772022  DT.208961  DT.100777807 

    24/183 AceView cDNA sequences (see all 183):

    BI090658 BC005963 BX505148 BU182773 CA415709 BQ431490 BF219695 NM_153488 
    CA488474 BM846958 AW628104 BM549169 NM_005361 AW673548 BU622519 BQ226610 
    BE795782 NM_175743 NM_005362 BM999965 BM781931 BM479202 AI222439 BM762699 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGEA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGATAACTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    MAGEA3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSpermatogonium Type BGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAGEA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAGEA3

    SOURCE GeneReport for Unigene cluster: Hs.417816

    UniProtKB/Swiss-Prot: MAGA3_HUMAN, P43357
    Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma,
    lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in
    kidney tumors, Leukemias and lymphomas

        SABiosciences Custom PCR Arrays for MAGEA3
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEA3
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat MAGEA3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEA3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAGEA3 gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    35(a)
    1 → many
    1(205669616-205678308)
    zebrafish
    (Danio rerio)
    Actinopterygii ndnl26
    necdin-like 2
    25(a)
    1 → many
    23(13012414-13025121)
    fruit fly
    (Drosophila melanogaster)
    Insecta MAGE6
    MAGE
    20(a)
    1 → many
    3R(2979960-2980898)


    ENSEMBL Gene Tree for MAGEA3 (if available)
    TreeFam Gene Tree for MAGEA3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGEA3 gene
    MAGEA61 2  MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB42  MAGEB12  MAGEC12  
    MAGED42  MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEE12  
    MAGED12  MAGEA22  MAGEC32  NDN2  MAGEB22  MAGEB32  MAGED4B2  MAGEE22  
    MAGEA42  MAGEA12  MAGEA102  MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  
    MAGEA112  NDNL22  MAGEF12  
    18/38 SIMAP similar genes for MAGEA3 using alignment to 2 protein entries:     MAGA3_HUMAN (see all proteins) (see all similar genes):
    MAGEA6    MAGEA12    MAGEA2B    MAGEA2    MAGEA5    MAGEA4
    MAGEA8    MAGEA11    MAGEA1    MAGEA9B    MAGEA9    MAGEC4
    MAGEH1    TRO    MAGEC3    MAGED4    MAGED4B    MAGEB16

    MAGEA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/62 NCBI SNPs in MAGEA3 are shown (see all 62    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475063031,2
    --151934848(+) CTTTTA/TCCACT 1 -- ut310--------
    rs1385581711,2
    --151934851(+) TTACCA/GCTGCT 1 -- ut310--------
    rs35671,2
    C,F,A,H,--151935150(-) CATCCC/GTTAGT 1 -- ut3113Minor allele frequency- G:0.13NS EA NA 1785
    rs712133831,2
    C,,--151935181(-) GGGGTC/TTGGGC 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs617500341,2
    C,F--151935240(+) TCTCTC/AAAAAC 2 /L /F mis12Minor allele frequency- A:0.00NS NA 4624
    rs357809741,2
    C,F--151935244(-) GTGGGT/CTTTGA 2 /A /V mis12Minor allele frequency- C:0.00NS NA 4622
    rs1461269491,2
    C,F--151935272(+) GGAAAT/CGTGAG 2 /I /V mis11Minor allele frequency- C:0.00NA 4546
    rs359874571,2
    C,F,--151935274(-) ACCTCA/GCATTT 2 H R mis11Minor allele frequency- G:0.00NA 4546
    rs617518911,2
    C,F,--151935288(+) CCACTG/AATCTT 2 /I syn12Minor allele frequency- A:0.01NS NA 4624
    rs359831181,2
    C,F,--151935332(-) CCCTCG/ATTGAA 2 /I /V mis12Minor allele frequency- A:0.00NA 4548

    HapMap Linkage Disequilibrium report for MAGEA3 (151934652 - 151938240 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MAGEA3
         1 CNV: 3273
    Locus Specific Mutation Databases (LSDB): MAGEA3

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEA3
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGEA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MAGEA3 for disorders           About GeneDecksing

    OMIM gene information: 300174    OMIM disorders: --

    20/53 diseases for MAGEA3 (see all 53):    About MalaCards
    dyskeratosis congenita    dyskeratosis    melanoma    bile duct cancer
    non-small cell lung carcinoma    non-hodgkin lymphoma    squamous cell carcinoma    chromophobe renal cell carcinoma
    avian influenza    ocular melanoma    cancer progression/metastasis    oral squamous cell carcinoma
    squamous cell carcinoma of the head and neck    renal oncocytoma    esophageal squamous cell carcinoma    renal cell carcinoma
    hodgkin's lymphoma    germ cell tumor    transitional cell carcinoma    testicular cancer

    2 diseases from the University of Copenhagen DISEASES database for MAGEA3:
    Melanoma     Lung cancer

    10/35 Novoseek disease relationships for MAGEA3 gene (see all 35)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 81.8 90 15570431 (3), 10546159 (3), 7805731 (2), 15305155 (2) (see all 61)
    metastatic melanoma 75.8 17 15945101 (2), 12973032 (1), 9935203 (1), 11511319 (1) (see all 12)
    testicular cancer 70.4 3 14991579 (1), 12855658 (1), 12681059 (1)
    tumors 60.5 125 15570431 (4), 18505125 (4), 8900375 (4), 7805731 (3) (see all 67)
    hepatocellular carcinoma 48.1 22 19260505 (4), 10961717 (3), 16806006 (2), 11857021 (1) (see all 11)
    cancer 47.6 22 17007017 (3), 9815643 (2), 11329779 (2), 7805731 (1) (see all 16)
    ocular melanoma 42.9 2 9220316 (2)
    metastasis 42.2 10 15570431 (2), 11857021 (1), 15305155 (1), 15657294 (1) (see all 8)
    bile duct cancer 41.3 1 10873083 (1)
    gastric carcinoma 35.7 6 9854470 (3), 7557134 (2), 10431688 (1)


    Export disorders for MAGEA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGEA3 gene, integrated from 9 sources (see all 227):
    (articles sorted by number of sources associating them with MAGEA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. (PubMed id 8113684)1, 2, 9 Gaugler B.... Boon T. (1994)
    2. Cloning and analysis of MAGE-1-related genes. (PubMed id 8037761)1, 2, 9 Ding M.... Fenton R.G. (1994)
    3. MAGE-RING protein complexes comprise a family of E3 u biquitin ligases. (PubMed id 20864041)1, 2 Doyle J.M....Potts P.R. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Comparative genome sequence analysis of the Bpa/Str region in mouse and man. (PubMed id 10854409)1, 2 Mallon A.-M....Brown S.D.M. (2000)
    6. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
    7. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. (PubMed id 1840703)1, 3 van der Bruggen P.... Boon T. (1991)
    8. Fibroblast growth factor 2 and estrogen control the balance of histone 3 modifications targeting MAGE-A3 in pituitary neoplasia. (PubMed id 18381936)1, 9 Zhu X....Ezzat S. (2008)
    9. Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues. (PubMed id 17007017)1, 9 Kim K.H....Park J.G. (2006)
    10. [Expression of melanoma antigen-1, 3 genes in human intrahepatic cholangiocarcinoma and its clinical significance] (PubMed id 18505125)1, 9 Lu X....Huang J.F. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4102 HGNC: 6801 AceView: MAGEA2andMAGEA3andMAGEA12 Ensembl:ENSG00000221867 euGenes: HUgn4102
    ECgene: MAGEA3 H-InvDB: MAGEA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAGEA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEA3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAGEA3 gene:
    Search GeneIP for patents involving MAGEA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for MAGEA3   OriGene shRNA RFP for MAGEA3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAGEA3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEA3  
     OriGene Protein Over-expression Lysate for MAGEA3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MAGEA3   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for MAGEA3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAGEA3   OriGene Custom Protein Services for MAGEA3  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAGEA3
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEA3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAGEA3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEA3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEA3
     GenScript Custom Purified and Recombinant Proteins Services for MAGEA3 GenScript cDNA clones with any tag delivered in your preferred vector for MAGEA3
     GenScript Custom Assay Services for MAGEA3 GenScript Custom Superior Antibodies Services for MAGEA3
     GenScript Custom overexpressing Cell Line Services for MAGEA3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MAGEA3 promoter
     Search Chromatin IP Primers for MAGEA3
     Search RT2 qPCR Primer Assays in human, mouse, rat MAGEA3
     Search GNC Networks for MAGEA3
     SABiosciences Custom PCR Arrays for MAGEA3
     Search Tocris compounds for MAGEA3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MAGEA3 antibodies
     MAGEA3 proteins
     MAGEA3 lysates
     Search for Antibodies for MAGEA3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MAGEA3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for MAGEA3




     MAGEA3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MAGEA3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA3
     SwitchGear 3'UTR luciferase reporter plasmids for MAGEA3
     Browse SwitchGear Promoter luciferase reporter plasmids for MAGEA3
     ThermoFisher Antibodies for MAGEA3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEA3
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAGEA3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4