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Aliases for MAGEA3 Gene

Aliases for MAGEA3 Gene

  • MAGE Family Member A3 2 3 5
  • MAGE-3 Antigen 2 3 4
  • Antigen MZ2-D 2 3 4
  • Melanoma Antigen Family A3 2 3
  • Cancer/Testis Antigen 1.3 3 4
  • MAGE3 3 4
  • CT1.3 3 4
  • Cancer/Testis Antigen Family 1, Member 3 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma-Associated Antigen 3 2
  • Melanoma Antigen Family A, 3 3
  • Member 3 2
  • MAGEA6 3
  • HIP8 3
  • HYPD 3

External Ids for MAGEA3 Gene

Previous HGNC Symbols for MAGEA3 Gene

  • MAGE3

Previous GeneCards Identifiers for MAGEA3 Gene

  • GC0XM146274
  • GC0XM148591
  • GC0XM149682
  • GC0XM150552
  • GC0XM151605
  • GC0XM151685
  • GC0XM151934
  • GC0XM140736

Summaries for MAGEA3 Gene

Entrez Gene Summary for MAGEA3 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA3 Gene

MAGEA3 (MAGE Family Member A3) is a Protein Coding gene. Diseases associated with MAGEA3 include melanoma and hepatocellular carcinoma. An important paralog of this gene is MAGEC3.

UniProtKB/Swiss-Prot for MAGEA3 Gene

  • Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Gene Wiki entry for MAGEA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA3 Gene

Genomics for MAGEA3 Gene

Regulatory Elements for MAGEA3 Gene

Genomic Location for MAGEA3 Gene

Chromosome:
X
Start:
152,698,732 bp from pter
End:
152,702,347 bp from pter
Size:
3,616 bases
Orientation:
Plus strand

Genomic View for MAGEA3 Gene

Genes around MAGEA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA3 Gene

Proteins for MAGEA3 Gene

  • Protein details for MAGEA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43357-MAGA3_HUMAN
    Recommended name:
    Melanoma-associated antigen 3
    Protein Accession:
    P43357
    Secondary Accessions:
    • Q6FHI6

    Protein attributes for MAGEA3 Gene

    Size:
    314 amino acids
    Molecular mass:
    34747 Da
    Quaternary structure:
    • Interacts with TRIM28.

    Three dimensional structures from OCA and Proteopedia for MAGEA3 Gene

neXtProt entry for MAGEA3 Gene

Proteomics data for MAGEA3 Gene at MOPED

Post-translational modifications for MAGEA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEA3 Gene

Domains & Families for MAGEA3 Gene

Gene Families for MAGEA3 Gene

Protein Domains for MAGEA3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43357

UniProtKB/Swiss-Prot:

MAGA3_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEA3: view

Function for MAGEA3 Gene

Molecular function for MAGEA3 Gene

GENATLAS Biochemistry:
human melanoma antigen,family A,member 3,expressed in melanoma,testis,advanced gastric carcinomas and hepatocellular carcinomas
UniProtKB/Swiss-Prot Function:
Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Phenotypes for MAGEA3 Gene

GenomeRNAi human phenotypes for MAGEA3:
genes like me logo Genes that share phenotypes with MAGEA3: view

Animal Model Products

miRNA for MAGEA3 Gene

miRTarBase miRNAs that target MAGEA3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEA3 Gene

Localization for MAGEA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEA3 Gene COMPARTMENTS Subcellular localization image for MAGEA3 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 3
nucleus 2
endosome 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEA3 Gene

Pathways & Interactions for MAGEA3 Gene

SuperPathways for MAGEA3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 12097332
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP 12097332
genes like me logo Genes that share ontologies with MAGEA3: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEA3 Gene

Drugs & Compounds for MAGEA3 Gene

(4) Drugs for MAGEA3 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Astuprotimut-R Pharma Vaccine Vaccines 0
EP-2101 Pharma Vaccine Vaccines 0
GSK1572932A Pharma Vaccine Vaccines 0
MAGE-A3 Pharma 0

(4) Additional Compounds for MAGEA3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAGEA3: view

Transcripts for MAGEA3 Gene

Unigene Clusters for MAGEA3 Gene

Melanoma antigen family A, 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA3 Gene

No ASD Table

Relevant External Links for MAGEA3 Gene

GeneLoc Exon Structure for
MAGEA3
ECgene alternative splicing isoforms for
MAGEA3

Expression for MAGEA3 Gene

mRNA expression in normal human tissues for MAGEA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEA3 Gene

This gene is overexpressed in Testis (x49.5).

Protein differential expression in normal tissues from HIPED for MAGEA3 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEA3 Gene



SOURCE GeneReport for Unigene cluster for MAGEA3 Gene Hs.417816

mRNA Expression by UniProt/SwissProt for MAGEA3 Gene

P43357-MAGA3_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas.
genes like me logo Genes that share expression patterns with MAGEA3: view

Protein tissue co-expression partners for MAGEA3 Gene

Primer Products

In Situ Assay Products

Orthologs for MAGEA3 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA3 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia 1700080O16Rik 36
  • 38 (a)
ManyToMany
3830417A13Rik 36
  • 38 (a)
ManyToMany
Magea1 36
  • 38 (a)
ManyToMany
Magea10 36
  • 40 (a)
ManyToMany
Magea2 36
  • 37 (a)
ManyToMany
Magea3 36
  • 38 (a)
ManyToMany
Magea4 36
  • 37 (a)
ManyToMany
Magea5 36
  • 38 (a)
ManyToMany
Magea6 36
  • 39 (a)
ManyToMany
Magea8 36
  • 38 (a)
ManyToMany
Species with no ortholog for MAGEA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA3 Gene

ENSEMBL:
Gene Tree for MAGEA3 (if available)
TreeFam:
Gene Tree for MAGEA3 (if available)

Paralogs for MAGEA3 Gene

genes like me logo Genes that share paralogs with MAGEA3: view

Variants for MAGEA3 Gene

Sequence variations from dbSNP and Humsavar for MAGEA3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1047232 -- 152,702,096(-) TTTTA(C/T)TCAGA utr-variant-3-prime
rs34624093 -- 152,701,464(-) CGCAA(A/G)AGAGG reference, missense
rs35319241 -- 152,701,433(-) CAGGC(C/T)TCCTG reference, missense
rs35983118 -- 152,701,667(-) CCCTC(A/G)TTGAA reference, missense
rs35014283 -- 152,701,175(-) TGGCC(A/G)AGTTG reference, missense, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for MAGEA3 Gene

Variant ID Type Subtype PubMed ID
dgv2493e1 CNV Complex 17122850

Variation tolerance for MAGEA3 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEA3 Gene

HapMap Linkage Disequilibrium report
MAGEA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA3 Gene

Disorders for MAGEA3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MAGEA3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
dyskeratosis congenita
  • revesz syndrome
lung cancer
  • lung cancer, protection against
femoral neuropathy
  • femoral nerve lesions
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEA3
genes like me logo Genes that share disorders with MAGEA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA3 Gene

Publications for MAGEA3 Gene

  1. Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. (PMID: 8113684) Gaugler B. … Boon T. (J. Exp. Med. 1994) 3 4 23 67
  2. Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines. (PMID: 20423514) Zhang S. … Yu Y. (BMC Cancer 2010) 3 23
  3. Melanoma gene expression and clinical course. (PMID: 19326132) Vourc'h-Jourdain M. … Dreno B. (Arch. Dermatol. Res. 2009) 3 23
  4. [Expression of melanoma antigen-1, 3 genes in human intrahepatic cholangiocarcinoma and its clinical significance]. (PMID: 18505125) Lu X. … Huang J.F. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2008) 3 23
  5. Fibroblast growth factor 2 and estrogen control the balance of histone 3 modifications targeting MAGE-A3 in pituitary neoplasia. (PMID: 18381936) Zhu X. … Ezzat S. (Clin. Cancer Res. 2008) 3 23

Products for MAGEA3 Gene

Sources for MAGEA3 Gene

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