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Aliases & Descriptions for MAGEA3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CT1.3 1, 2, 3 | | HIP8 1, 2 | | HYPD 1, 2 | | MAGE3 2, 3, 5 | | MAGEA6 2 | | MGC14613 1, 2 | | OTTHUMP00000024220 2 |
| | | Descriptions |
|---|
| Antigen MZ2-D 2, 3 | | Cancer/testis antigen 1.3 3 | | MAGE-3 antigen 2, 3 | | cancer/testis antigen family 1, member 3 2 | | melanoma antigen family A, 3 2 | | melanoma-associated antigen 3 2 |
|
| | Search outside databases for aliases for MAGEA3 genePrevious GC identifers: GC0XM146274 GC0XM148591 GC0XM149682 GC0XM150552 GC0XM151605 |
Summaries for MAGEA3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for MAGEA3: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq] UniProtKB/Swiss-Prot: MAGA3_HUMAN, P43357Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytesGene Wiki entry for MAGEA3 |
Genomic Location for MAGEA3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the MAGEA3 gene 
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28MAGEA3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM151685:
(about GC identifiers)
Start:
|
151,685,308 bp from pter |
End:
|
151,688,896 bp from pter |
Size:
|
3,589 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011726.13
| Proteins for MAGEA3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MAGA3_HUMAN, P43357 (See
protein sequence)Recommended Name: Melanoma-associated antigen 3 Size: 314 amino acids; 34747 Da
PDB structures from and Proteopedia :1QEW (3D)
 REFSEQ proteins: NP_005353.1
ENSEMBL proteins: ENSP00000359301 ENSP00000377447
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for MAGEA3: Assays for MAGEA3: | Protein
Domains/ Families for MAGEA3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P43357
ProtoNet protein and cluster: P43357 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGA3_HUMAN, P43357Similarity: Contains 1 MAGE domain | Gene Function for MAGEA3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005362
Applied Biosystems Silencer® siRNAs for MAGEA3
Sigma-Aldrich siRNA for MAGEA3  Sigma-Aldrich shRNA Panels and shRNA for MAGEA3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005362                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005362                                  untagged cDNA clone in CMV expression vector: NM_005362 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005362
UniProtKB/Swiss-Prot: MAGA3_HUMAN, P43357Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytesGenatlas biochemistry entry for MAGEA3:human melanoma antigen,family A,member 3,expressed in melanoma,testis,advanced gastric carcinomas and hepatocellular carcinomas | Pathways & Interactions for MAGEA3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/12 Interacting proteins for MAGEA3 (ENSP000003593013) via UniProtKB, MINT, and/or STRING (see all 12
)About this table
|
Drugs & Compounds for MAGEA3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for MAGEA3 2 Novoseek chemical compound relationships for MAGEA3 gene
About this table
|
Transcripts for MAGEA3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005362
Sigma-Aldrich siRNA for MAGEA3  Sigma-Aldrich shRNA Panels and shRNA for MAGEA3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005362 REFSEQ mRNAs for MAGEA3 gene: NM_005362.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005362               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005362                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005362                                  untagged cDNA clone in CMV expression vector: NM_005362  Additional cDNA sequence: AK223519.1 AK292384.1 BC000340.2 BC005963.1 BC011744.2 BC016803.1 BC017389.1 CR541767.1 CR541768.1 CR541774.1 CR542020.1 3 DOTS entries: DT.91772022 DT.208961 DT.100777807 24/183 AceView cDNA sequences (see all 183
):BC063681 CR541774 BU622519 BC005963 BC000340 BC003408 CA488474 BE901056 BC017389 BC011744 CB145878 BF791772 BM449726 NM_005361 AI222439 BM762699 BX106621 BU182773 NM_175743 BQ226610 BM846958 BG575302 AA905896 CA429655
highest scoring ESTs for MAGEA3:BX505148 BE275759 CR746976 DB518773 EC446339 EC459045 EC489463 EC500116 EC502964 EC542499 Unigene Cluster for MAGEA3: Melanoma antigen family A, 3 Hs.417816 [show with all ESTs]Unigene Representative Sequence: NM_005362
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000370278
ENST00000393869
|
Expression for MAGEA3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MAGEA3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MAGEA3
1 / 2 / 3 6 probe-sets matching MAGEA3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGATAACTCA
SOURCE GeneReport for Unigene cluster: Hs.417816
Expression variation in blood from EXPOLDB for MAGEA3 UniProtKB/Swiss-Prot: MAGA3_HUMAN, P43357Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas |
Orthologs for MAGEA3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for MAGEA3 | Paralogs for MAGEA3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for MAGEA3 gene
- MAGEA61 2 MAGEA2B2 MAGEA82 MAGEA122 MAGEA92 MAGEA9B2 MAGEA42 MAGEA112
- MAGEA12 MAGEA102 MAGEA22
|
SNPs/Variants for MAGEA3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for MAGEA3 (up to first 250kb)
|
Disorders & Mutations for MAGEA3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300174
10/34 Novoseek disease relationships for MAGEA3 gene (see all 34
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| melanoma |
82.11 |
88 |
15570431 (3), 10546159 (3), 7805731 (2), 15305155 (2) (see all 59) |
| metastatic melanoma |
76.65 |
17 |
15945101 (2), 12973032 (1), 9935203 (1), 11511319 (1) (see all 12) |
| testicular cancer |
71.25 |
3 |
14991579 (1), 12855658 (1), 12681059 (1) |
| tumors |
60.64 |
117 |
15570431 (4), 18505125 (4), 8900375 (4), 7805731 (3) (see all 63) |
| hepatocellular carcinoma |
49.55 |
22 |
19260505 (4), 10961717 (3), 16806006 (2), 11857021 (1) (see all 11) |
| cancer |
47.93 |
21 |
17007017 (3), 9815643 (2), 11329779 (2), 7805731 (1) (see all 15) |
| ocular melanoma |
43.75 |
2 |
9220316 (2) |
| bile duct cancer |
42.56 |
1 |
10873083 (1) |
| metastasis |
41.82 |
10 |
15570431 (2), 11857021 (1), 15305155 (1), 15657294 (1) (see all 8) |
| gastric carcinoma |
36.77 |
6 |
9854470 (3), 7557134 (2), 10431688 (1) |
About this table
|
Medical News for MAGEA3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for MAGEA3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/197 PubMed articles for MAGEA3 gene (see all 197
):- Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. (PubMed id 8113684)1, 3, 4 Gaugler B.... Boon T. (1994)
- Cloning and analysis of MAGE-1-related genes. (PubMed id 8037761)1, 3, 4 Ding M.... Fenton R.G. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. (PubMed id 10854409)3, 4 Mallon A.M....Brown S.D. (2000)
- The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)2, 3 Rogner U.C....Poustka A. (1995)
- A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. (PubMed id 1840703)2, 3 van der Bruggen P.... Boon T. (1991)
- Fibroblast growth factor 2 and estrogen control the balance of histone 3 modifications targeting MAGE-A3 in pituitary neoplasia. (PubMed id 18381936)1, 3 Zhu X....Ezzat S. (2008)
- Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues. (PubMed id 17007017)1, 3 Kim K.H....Park J.G. (2006)
- Analysis of MAGE-3-specific cytolytic T lymphocytes in human leukocyte antigen-A2 melanoma patients. (PubMed id 9044853)1, 3 Valmori D....Romero P. (1997)
- Identification and intracellular location of MAGE-3 gene product. (PubMed id 7757970)1, 3 Kocher T....Spagnoli G.C. (1995)
|
Search for MAGEA3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MAGEA3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MAGEA3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEA3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for MAGEA3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for MAGEA3:

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