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Aliases &
Descriptions
for MAGEA2B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| CT1.2 3 | | MAGE2 1, 2, 3 | | MAGEA2 1, 2, 3 | | MAGEA2A 3 | | MAGEA2b 1 | | MGC16973 1, 2 | | OTTHUMP00000024226 2 |
| | | Descriptions |
|---|
| Cancer/testis antigen 1.2 3 | | MAGE-2 antigen 3 | | melanoma antigen 2 2 | | melanoma antigen family A, 2B 2 | | melanoma antigen, family A, 2, copy b 2 | | melanoma-associated antigen 2 2 |
|
| |
Search outside databases for aliases for MAGEA2B genePrevious GC identifers: GC0XP150502 GC0XP151538 GC0XM151670 |
Summaries
for MAGEA2B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for MAGEA2B:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50
to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show
considerable variability, suggesting that the existence of this gene family enables the same
function to be expressed under different transcriptional controls. The MAGEA genes are clustered
at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as
dyskeratosis congenita. This gene has two identical copies at different loci. [provided by RefSeq]
UniProtKB/Swiss-Prot: MAGA2_HUMAN, P43356Function: Not known, though may play a role in embryonal development and tumor transformation or
aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic
T-lymphocytes |
Genomic Location
for MAGEA2B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the MAGEA2B gene 
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28MAGEA2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP151633:
(about GC identifiers)
Start:
|
151,633,746 bp from pter |
End:
|
151,637,752 bp from pter |
Size:
|
4,007 bases |
Orientation:
|
plus strand |
| Proteins
for MAGEA2B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MAGA2_HUMAN, P43356 (See
protein sequence)Recommended Name: Melanoma-associated antigen 2 Size: 314 amino acids; 35055 Da
Secondary accessions: Q32NC6REFSEQ proteins: NP_705692.1
ENSEMBL proteins: ENSP00000377477 ENSP00000333487 ENSP00000359316 ENSP00000386463
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
Antibodies for MAGEA2B:
Assays for MAGEA2B: | Protein
Domains/
Families
for MAGEA2B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P43356
ProtoNet protein and cluster: P43356 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGA2_HUMAN, P43356Similarity: Contains 1 MAGE domain | Gene Function
for MAGEA2B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153488
 Applied Biosystems Silencer® siRNAs for MAGEA2B
 Sigma-Aldrich siRNA for MAGEA2B
Sigma-Aldrich shRNA for MAGEA2B
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_153488
Myc/DDK tagged cDNA clone in CMV expression vector: NM_153488
untagged cDNA clone in CMV expression vector: NM_153488
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_153488
UniProtKB/Swiss-Prot: MAGA2_HUMAN, P43356Function: Not known, though may play a role in embryonal development and tumor transformation or
aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic
T-lymphocytes | Pathways & Interactions
for MAGEA2B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
-- |
Drugs & Compounds
for MAGEA2B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for MAGEA2B
|
Transcripts
for MAGEA2B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153488
Sigma-Aldrich siRNA for MAGEA2B
Sigma-Aldrich shRNA for MAGEA2B
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_153488 REFSEQ mRNAs for MAGEA2B gene: NM_153488.3
OriGene GFP tagged cDNA clone in CMV expression vector: NM_153488
Myc/DDK tagged cDNA clone in CMV expression vector: NM_153488
untagged cDNA clone in CMV expression vector: NM_153488
24/183 AceView cDNA sequences (see all 183
):AW673548 CA429655 BM762699 AI222439 BM479202 BC003408 NM_175742 BQ431490 CB145878 BF219695 BU622519 BQ436888 CR594285 BC000340 BC063681 NM_005361 CA415709 BC017389 CA488474 BM781931 AA905896 CD557117 BI090658 BG575302
 highest scoring ESTs for MAGEA2B:AW731700 BF791379 BC013098 AL044465 AW673548 BF793468 BF970108 BI093960 BQ020664 BU622519
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations: ENST00000393899
ENST00000331220
ENST00000370293
ENST00000409560
|
Expression
for MAGEA2B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MAGEA2B expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching MAGEA2B gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
UniProtKB/Swiss-Prot: MAGA2_HUMAN, P43356Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck
squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for
testes |
Orthologs
for MAGEA2B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for MAGEA2B | Paralogs
for MAGEA2B(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MAGEA2B gene
- MAGEA21 2 MAGEA32 MAGEA82 MAGEA122 MAGEA92 MAGEA9B2 MAGEA42 MAGEA112
- MAGEA12 MAGEA102 MAGEA62
|
SNPs/Variants
for MAGEA2B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations
for MAGEA2B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300549
|
Medical News
for MAGEA2B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MAGEA2B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for MAGEA2B gene:- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. (PubMed id 10854409)3, 4 Mallon A.M....Brown S.D. (2000)
- The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)2, 3 Rogner U.C....Poustka A. (1995)
- Sequence and expression pattern of the human MAGE2 gene. (PubMed id 8276455)3, 4 De Smet C....Boon T. (1994)
- Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. (PubMed id 8113684)3, 4 Gaugler B.... Boon T. (1994)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)3 De Plaen E.... Boon T. (1994)
- A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. (PubMed id 1840703)3 van der Bruggen P.... Boon T. (1991)
|
Search for MAGEA2B
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEA2B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MAGEA2B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEA2B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for MAGEA2B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for MAGEA2B:
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