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Aliases for MAGEA2B Gene

Aliases for MAGEA2B Gene

  • MAGE Family Member A2B 2 3 5
  • Melanoma Antigen Family A2B 2 3
  • Cancer/Testis Antigen 1.2 3 4
  • MAGE-2 Antigen 3 4
  • MAGE2 3 4
  • CT1.2 3 4
  • Melanoma Antigen, Family A, 2, Copy B 3
  • Melanoma Antigen Family A, 2B 3
  • Melanoma Antigen 2 3
  • MAGEA2 MAGEA2B 4
  • MAGEA2A 4
  • MAGEA2 4

External Ids for MAGEA2B Gene

Previous GeneCards Identifiers for MAGEA2B Gene

  • GC0XP150502
  • GC0XP151538
  • GC0XM151670
  • GC0XP151633
  • GC0XP151883

Summaries for MAGEA2B Gene

Entrez Gene Summary for MAGEA2B Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA2B Gene

MAGEA2B (MAGE Family Member A2B) is a Protein Coding gene. Diseases associated with MAGEA2B include melanoma and dyskeratosis congenita. GO annotations related to this gene include ubiquitin protein ligase binding and repressing transcription factor binding. An important paralog of this gene is MAGEC3.

UniProtKB/Swiss-Prot for MAGEA2B Gene

  • Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA2B Gene

Genomics for MAGEA2B Gene

Regulatory Elements for MAGEA2B Gene

Genomic Location for MAGEA2B Gene

Chromosome:
X
Start:
152,714,502 bp from pter
End:
152,718,607 bp from pter
Size:
4,106 bases
Orientation:
Plus strand

Genomic View for MAGEA2B Gene

Genes around MAGEA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA2B Gene

Proteins for MAGEA2B Gene

  • Protein details for MAGEA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43356-MAGA2_HUMAN
    Recommended name:
    Melanoma-associated antigen 2
    Protein Accession:
    P43356
    Secondary Accessions:
    • A8K328
    • Q32NC6

    Protein attributes for MAGEA2B Gene

    Size:
    314 amino acids
    Molecular mass:
    35055 Da
    Quaternary structure:
    • Interacts with TRIM28 and UBE2H. Interacts with HDAC3. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5).
    • Interacts with TRIM28 and UBE2H. Interacts with HDAC3. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5).

neXtProt entry for MAGEA2B Gene

Proteomics data for MAGEA2B Gene at MOPED

Post-translational modifications for MAGEA2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGEA2B Gene

Domains & Families for MAGEA2B Gene

Gene Families for MAGEA2B Gene

Protein Domains for MAGEA2B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEA2B Gene

Graphical View of Domain Structure for InterPro Entry

P43356

UniProtKB/Swiss-Prot:

MAGA2_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEA2B: view

Function for MAGEA2B Gene

Molecular function for MAGEA2B Gene

UniProtKB/Swiss-Prot Function:
Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Phenotypes for MAGEA2B Gene

GenomeRNAi human phenotypes for MAGEA2B:
genes like me logo Genes that share phenotypes with MAGEA2B: view

Animal Model Products

CRISPR Products

miRNA for MAGEA2B Gene

miRTarBase miRNAs that target MAGEA2B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEA2B Gene

Localization for MAGEA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEA2B Gene

Nucleus. Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEA2B Gene COMPARTMENTS Subcellular localization image for MAGEA2B gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for MAGEA2B Gene

Pathways & Interactions for MAGEA2B Gene

SuperPathways for MAGEA2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16847267
GO:0006351 transcription, DNA-templated IEA --
GO:0033234 negative regulation of protein sumoylation IDA 22117195
GO:0090398 cellular senescence IDA 22117195
genes like me logo Genes that share ontologies with MAGEA2B: view

No data available for Pathways by source and SIGNOR curated interactions for MAGEA2B Gene

Drugs & Compounds for MAGEA2B Gene

No Compound Related Data Available

Transcripts for MAGEA2B Gene

Unigene Clusters for MAGEA2B Gene

Melanoma antigen family A, 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA2B Gene

No ASD Table

Relevant External Links for MAGEA2B Gene

GeneLoc Exon Structure for
MAGEA2B
ECgene alternative splicing isoforms for
MAGEA2B

Expression for MAGEA2B Gene

mRNA expression in normal human tissues for MAGEA2B Gene

mRNA differential expression in normal tissues according to GTEx for MAGEA2B Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for MAGEA2B Gene

This gene is overexpressed in Bone (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAGEA2B Gene



SOURCE GeneReport for Unigene cluster for MAGEA2B Gene Hs.534597

mRNA Expression by UniProt/SwissProt for MAGEA2B Gene

P43356-MAGA2_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
genes like me logo Genes that share expression patterns with MAGEA2B: view

Protein tissue co-expression partners for MAGEA2B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGEA2B Gene

Orthologs for MAGEA2B Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEA2 35
  • 98.73 (n)
  • 97.12 (a)
mouse
(Mus musculus)
Mammalia 1700080O16Rik 36
  • 38 (a)
ManyToMany
3830417A13Rik 36
  • 38 (a)
ManyToMany
Magea1 36
  • 38 (a)
ManyToMany
Magea10 36
  • 41 (a)
ManyToMany
Magea2 36
  • 38 (a)
ManyToMany
Magea3 36
  • 38 (a)
ManyToMany
Magea4 36
  • 39 (a)
ManyToMany
Magea5 36
  • 39 (a)
ManyToMany
Magea6 36
  • 40 (a)
ManyToMany
Magea8 36
  • 38 (a)
ManyToMany
Species with no ortholog for MAGEA2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA2B Gene

ENSEMBL:
Gene Tree for MAGEA2B (if available)
TreeFam:
Gene Tree for MAGEA2B (if available)

Paralogs for MAGEA2B Gene

genes like me logo Genes that share paralogs with MAGEA2B: view

Variants for MAGEA2B Gene

Sequence variations from dbSNP and Humsavar for MAGEA2B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs6627648 -- 152,719,067(+) AAGAT(C/T)TAGGT downstream-variant-500B
rs6627663 -- 152,719,089(-) TTGCA(A/G)ATGAT downstream-variant-500B
rs6627665 -- 152,718,888(-) CATTA(A/G)AATCA downstream-variant-500B
rs199764571 -- 152,717,854(-) CACCA(A/G)ATCTT reference, synonymous-codon
rs201464439 -- 152,717,598(+) ACCTC(A/G)ATGCC reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for MAGEA2B Gene

Variant ID Type Subtype PubMed ID
dgv2493e1 CNV Complex 17122850

Relevant External Links for MAGEA2B Gene

HapMap Linkage Disequilibrium report
MAGEA2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MAGEA2B Gene

Disorders for MAGEA2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAGEA2B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
dyskeratosis congenita
  • revesz syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEA2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEA2B
genes like me logo Genes that share disorders with MAGEA2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA2B Gene

Publications for MAGEA2B Gene

  1. MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs. (PMID: 22117195) Peche L.Y. … Schneider C. (Cell Death Differ. 2012) 3 4 67
  2. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner U.C. … Poustka A. (Genomics 1995) 2 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for MAGEA2B Gene

Sources for MAGEA2B Gene

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