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Aliases for MAGEA2 Gene

Aliases for MAGEA2 Gene

  • Melanoma Antigen Family A2 2 3
  • MAGE2 3 4 6
  • Cancer/Testis Antigen 1.2 3 4
  • MAGE-2 Antigen 3 4
  • MAGEA2A 3 4
  • CT1.2 3 4
  • Cancer/Testis Antigen Family 1, Member 2 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma-Associated Antigen 2 3
  • Melanoma Antigen Family A, 2 3
  • Melanoma Antigen 2 3
  • MAGEA2 MAGEA2B 4
  • Member 2 2

External Ids for MAGEA2 Gene

Previous Symbols for MAGEA2 Gene

  • MAGE2

Summaries for MAGEA2 Gene

Entrez Gene Summary for MAGEA2 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA2 Gene

MAGEA2 (Melanoma Antigen Family A2) is a Protein Coding gene. Diseases associated with MAGEA2 include oral squamous cell carcinoma and dyskeratosis congenita. An important paralog of this gene is MAGEA2B.

UniProtKB/Swiss-Prot for MAGEA2 Gene

  • Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Gene Wiki entry for MAGEA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA2 Gene

Genomics for MAGEA2 Gene

Genomic Location for MAGEA2 Gene

Start:
152,749,863 bp from pter
End:
152,753,884 bp from pter
Size:
4,022 bases
Orientation:
Minus strand

Genomic View for MAGEA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA2 Gene

Regulatory Elements for MAGEA2 Gene

Transcription factor binding sites by QIAGEN in the MAGEA2 gene promoter:

Proteins for MAGEA2 Gene

  • Protein details for MAGEA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43356-MAGA2_HUMAN
    Recommended name:
    Melanoma-associated antigen 2
    Protein Accession:
    P43356
    Secondary Accessions:
    • A8K328
    • Q32NC6

    Protein attributes for MAGEA2 Gene

    Size:
    314 amino acids
    Molecular mass:
    35055 Da
    Quaternary structure:
    • Interacts with TRIM28 and UBE2H. Interacts with HDAC3. Interacts with PML (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5).

neXtProt entry for MAGEA2 Gene

Proteomics data for MAGEA2 Gene at MOPED

Post-translational modifications for MAGEA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAGEA2 Gene

Domains for MAGEA2 Gene

Protein Domains for MAGEA2 Gene

UniProtKB/Swiss-Prot:

MAGA2_HUMAN
Domain:
  • Contains 1 MAGE domain.:
    • P43356
genes like me logo Genes that share domains with MAGEA2: view

No data available for Gene Families for MAGEA2 Gene

Function for MAGEA2 Gene

Molecular function for MAGEA2 Gene

GENATLAS Biochemistry: human melanoma antigen,family A,member 2,expressed in melanoma,testis and advanced gastric carcinomas
UniProtKB/Swiss-Prot Function: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Gene Ontology (GO) - Molecular Function for MAGEA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16847267
GO:0031625 ubiquitin protein ligase binding IDA 20864041
GO:0042826 histone deacetylase binding IDA 16847267
GO:0070491 repressing transcription factor binding IDA 16847267
genes like me logo Genes that share ontologies with MAGEA2: view

Phenotypes for MAGEA2 Gene

GenomeRNAi human phenotypes for MAGEA2:
genes like me logo Genes that share phenotypes with MAGEA2: view

miRNA for MAGEA2 Gene

miRTarBase miRNAs that target MAGEA2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAGEA2 Gene

Localization for MAGEA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEA2 Gene

Nucleus. Nucleus, PML body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEA2 Gene COMPARTMENTS Subcellular localization image for MAGEA2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MAGEA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16847267
GO:0016605 PML body IDA 22117195
genes like me logo Genes that share ontologies with MAGEA2: view

Pathways for MAGEA2 Gene

SuperPathways for MAGEA2 Gene

No Data Available

Interacting Proteins for MAGEA2 Gene

Gene Ontology (GO) - Biological Process for MAGEA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16847267
GO:0006351 transcription, DNA-templated IEA --
GO:0033234 negative regulation of protein sumoylation IDA 22117195
GO:0044257 cellular protein catabolic process IMP 20864041
GO:0051443 positive regulation of ubiquitin-protein transferase activity IMP 20864041
genes like me logo Genes that share ontologies with MAGEA2: view

No data available for Pathways by source for MAGEA2 Gene

Transcripts for MAGEA2 Gene

Unigene Clusters for MAGEA2 Gene

Melanoma antigen family A, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA2 Gene

No ASD Table

Relevant External Links for MAGEA2 Gene

GeneLoc Exon Structure for
MAGEA2
ECgene alternative splicing isoforms for
MAGEA2

Expression for MAGEA2 Gene

mRNA expression in normal human tissues for MAGEA2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MAGEA2 Gene

SOURCE GeneReport for Unigene cluster for MAGEA2 Gene Hs.713061

mRNA Expression by UniProt/SwissProt for MAGEA2 Gene

P43356-MAGA2_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes
genes like me logo Genes that share expressions with MAGEA2: view

Orthologs for MAGEA2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MAGEA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEA2 36
  • 98.73 (n)
  • 97.12 (a)
Species with no ortholog for MAGEA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA2 Gene

ENSEMBL:
Gene Tree for MAGEA2 (if available)
TreeFam:
Gene Tree for MAGEA2 (if available)

Paralogs for MAGEA2 Gene

Paralogs for MAGEA2 Gene

genes like me logo Genes that share paralogs with MAGEA2: view

Variants for MAGEA2 Gene

Sequence variations from dbSNP and Humsavar for MAGEA2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1894355 -- 152,752,377(-) GGTAC(C/T)CCTGG intron-variant
rs6627646 -- 152,751,731(-) CCAAC(A/G)CTGAA utr-variant-5-prime, intron-variant
rs6627647 -- 152,749,869(-) TCTTC(C/T)TGTTC utr-variant-3-prime
rs200459473 -- 152,750,623(-) CTCAT(C/G)CAAGA missense, reference
rs201146248 -- 152,750,616(-) AAGAT(C/T)TGGTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MAGEA2 Gene

Variant ID Type Subtype PubMed ID
dgv2493e1 CNV Complex 17122850

Relevant External Links for MAGEA2 Gene

HapMap Linkage Disequilibrium report
MAGEA2

Disorders for MAGEA2 Gene

genes like me logo Genes that share disorders with MAGEA2: view

No data available for UniProtKB/Swiss-Prot for MAGEA2 Gene

Publications for MAGEA2 Gene

  1. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. (PMID: 1840703) van der Bruggen P. … Boon T. (Science 1991) 2 3
  2. Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. (PMID: 8113684) Gaugler B. … Boon T. (J. Exp. Med. 1994) 3 4
  3. Sequence and expression pattern of the human MAGE2 gene. (PMID: 8276455) De Smet C. … Boon T. (Immunogenetics 1994) 3 4
  4. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner U.C. … Poustka A. (Genomics 1995) 2 3
  5. Comparative genome sequence analysis of the Bpa/Str region in mouse and man. (PMID: 10854409) Mallon A.-M. … Brown S.D.M. (Genome Res. 2000) 3 4

Products for MAGEA2 Gene

Sources for MAGEA2 Gene

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