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Aliases for MAGEA12 Gene

Aliases for MAGEA12 Gene

  • MAGE Family Member A12 2 3 5
  • Melanoma Antigen Family A12 2 3
  • Cancer/Testis Antigen 1.12 3 4
  • MAGE12F Antigen 3 4
  • MAGE12 3 4
  • CT1.12 3 4
  • Cancer/Testis Antigen Family 1, Member 12 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma Antigen Family A, 12 3
  • MAGE-12 Antigen 4
  • Member 12 2

External Ids for MAGEA12 Gene

Previous HGNC Symbols for MAGEA12 Gene

  • MAGE12

Previous GeneCards Identifiers for MAGEA12 Gene

  • GC0XM146239
  • GC0XM148556
  • GC0XM149647
  • GC0XM150516
  • GC0XM151476
  • GC0XM151628
  • GC0XM151649
  • GC0XM151899
  • GC0XM140701

Summaries for MAGEA12 Gene

Entrez Gene Summary for MAGEA12 Gene

  • This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun 2014]

GeneCards Summary for MAGEA12 Gene

MAGEA12 (MAGE Family Member A12) is a Protein Coding gene. Diseases associated with MAGEA12 include Melanoma. An important paralog of this gene is MAGEC3.

UniProtKB/Swiss-Prot for MAGEA12 Gene

  • Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.

Gene Wiki entry for MAGEA12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA12 Gene

Genomics for MAGEA12 Gene

Regulatory Elements for MAGEA12 Gene


Promoters for MAGEA12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAGEA12 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAGEA12 Gene

Chromosome:
X
Start:
152,733,779 bp from pter
End:
152,737,669 bp from pter
Size:
3,891 bases
Orientation:
Plus strand

Genomic View for MAGEA12 Gene

Genes around MAGEA12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA12 Gene

Proteins for MAGEA12 Gene

  • Protein details for MAGEA12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43365-MAGAC_HUMAN
    Recommended name:
    Melanoma-associated antigen 12
    Protein Accession:
    P43365
    Secondary Accessions:
    • Q9NSD3

    Protein attributes for MAGEA12 Gene

    Size:
    314 amino acids
    Molecular mass:
    34836 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEA12 Gene

Proteomics data for MAGEA12 Gene at MOPED

Post-translational modifications for MAGEA12 Gene

  • Ubiquitination at Lys 244
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEA12 Gene

No data available for DME Specific Peptides for MAGEA12 Gene

Domains & Families for MAGEA12 Gene

Gene Families for MAGEA12 Gene

Protein Domains for MAGEA12 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEA12 Gene

Graphical View of Domain Structure for InterPro Entry

P43365

UniProtKB/Swiss-Prot:

MAGAC_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEA12: view

Function for MAGEA12 Gene

Molecular function for MAGEA12 Gene

GENATLAS Biochemistry:
human melanoma antigen,family A,member 12,expressed in melanoma,testis
UniProtKB/Swiss-Prot Function:
Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.
genes like me logo Genes that share phenotypes with MAGEA12: view

Animal Model Products

CRISPR Products

miRNA for MAGEA12 Gene

miRTarBase miRNAs that target MAGEA12

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEA12 Gene

Localization for MAGEA12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEA12 Gene COMPARTMENTS Subcellular localization image for MAGEA12 gene
Compartment Confidence
cytosol 2
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAGEA12 Gene

Pathways & Interactions for MAGEA12 Gene

SuperPathways for MAGEA12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEA12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEA12 Gene

Drugs & Compounds for MAGEA12 Gene

(1) Drugs for MAGEA12 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MAGE-12 peptide vaccine (emulsified inMontanide ISA-51) Pharma Vaccine Vaccines 0
genes like me logo Genes that share compounds with MAGEA12: view

Transcripts for MAGEA12 Gene

Unigene Clusters for MAGEA12 Gene

Melanoma antigen family A, 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA12 Gene

No ASD Table

Relevant External Links for MAGEA12 Gene

GeneLoc Exon Structure for
MAGEA12
ECgene alternative splicing isoforms for
MAGEA12

Expression for MAGEA12 Gene

mRNA expression in normal human tissues for MAGEA12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEA12 Gene

This gene is overexpressed in Testis (x24.6).

Protein differential expression in normal tissues from HIPED for MAGEA12 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEA12 Gene



SOURCE GeneReport for Unigene cluster for MAGEA12 Gene Hs.169246

mRNA Expression by UniProt/SwissProt for MAGEA12 Gene

P43365-MAGAC_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
genes like me logo Genes that share expression patterns with MAGEA12: view

Protein tissue co-expression partners for MAGEA12 Gene

- Elite partner

Primer Products

Orthologs for MAGEA12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEA12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEA12 35
  • 99.04 (n)
  • 98.73 (a)
MAGEA12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 40 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 1700080O16Rik 36
  • 38 (a)
ManyToMany
3830417A13Rik 36
  • 38 (a)
ManyToMany
Magea1 36
  • 38 (a)
ManyToMany
Magea10 36
  • 40 (a)
ManyToMany
Magea2 36
  • 37 (a)
ManyToMany
Magea3 36
  • 38 (a)
ManyToMany
Magea4 36
  • 38 (a)
ManyToMany
Magea5 36
  • 38 (a)
ManyToMany
Magea6 36
  • 39 (a)
ManyToMany
Magea8 36
  • 38 (a)
ManyToMany
Species with no ortholog for MAGEA12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA12 Gene

ENSEMBL:
Gene Tree for MAGEA12 (if available)
TreeFam:
Gene Tree for MAGEA12 (if available)

Paralogs for MAGEA12 Gene

Pseudogenes.org Pseudogenes for MAGEA12 Gene

genes like me logo Genes that share paralogs with MAGEA12: view

Variants for MAGEA12 Gene

Sequence variations from dbSNP and Humsavar for MAGEA12 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_053498 -

Structural Variations from Database of Genomic Variants (DGV) for MAGEA12 Gene

Variant ID Type Subtype PubMed ID
dgv2493e1 CNV Complex 17122850

Variation tolerance for MAGEA12 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAGEA12 Gene

Disorders for MAGEA12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAGEA12 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEA12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEA12
genes like me logo Genes that share disorders with MAGEA12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA12 Gene

Publications for MAGEA12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner U.C. … Poustka A. (Genomics 1995) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Preferential expression of cancer/testis genes in cancer stem-like cells: proposal of a novel sub-category, cancer/testis/stem gene. (PMID: 23574628) Yamada R. … Sato N. (Tissue Antigens 2013) 3
  5. Discovery and validation of DNA hypomethylation biomarkers for liver cancer using HRM-specific probes. (PMID: 23950870) Stefanska B. … Szyf M. (PLoS ONE 2013) 3

Products for MAGEA12 Gene

Sources for MAGEA12 Gene

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