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Aliases for MAGEA12 Gene

Aliases for MAGEA12 Gene

  • Melanoma Antigen Family A12 2 3
  • MAGE12 3 4 6
  • Cancer/Testis Antigen 1.12 3 4
  • MAGE12F Antigen 3 4
  • CT1.12 3 4
  • Cancer/Testis Antigen Family 1, Member 12 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma-Associated Antigen 12 3
  • Melanoma Antigen Family A, 12 3
  • MAGE-12 Antigen 4
  • Member 12 2

External Ids for MAGEA12 Gene

Previous HGNC Symbols for MAGEA12 Gene

  • MAGE12

Previous GeneCards Identifiers for MAGEA12 Gene

  • GC0XM146239
  • GC0XM148556
  • GC0XM149647
  • GC0XM150516
  • GC0XM151476
  • GC0XM151628
  • GC0XM151649
  • GC0XM151899
  • GC0XM140701

Summaries for MAGEA12 Gene

Entrez Gene Summary for MAGEA12 Gene

  • This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun 2014]

GeneCards Summary for MAGEA12 Gene

MAGEA12 (Melanoma Antigen Family A12) is a Protein Coding gene. Diseases associated with MAGEA12 include oral squamous cell carcinoma and dyskeratosis congenita. An important paralog of this gene is MAGED1.

UniProtKB/Swiss-Prot for MAGEA12 Gene

  • Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.

Gene Wiki entry for MAGEA12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA12 Gene

Genomics for MAGEA12 Gene

Regulatory Elements for MAGEA12 Gene

Genomic Location for MAGEA12 Gene

Start:
152,733,779 bp from pter
End:
152,737,669 bp from pter
Size:
3,891 bases
Orientation:
Plus strand

Genomic View for MAGEA12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEA12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA12 Gene

Proteins for MAGEA12 Gene

  • Protein details for MAGEA12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43365-MAGAC_HUMAN
    Recommended name:
    Melanoma-associated antigen 12
    Protein Accession:
    P43365
    Secondary Accessions:
    • Q9NSD3

    Protein attributes for MAGEA12 Gene

    Size:
    314 amino acids
    Molecular mass:
    34836 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEA12 Gene

Proteomics data for MAGEA12 Gene at MOPED

Post-translational modifications for MAGEA12 Gene

  • Ubiquitination at Lys244
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEA12 Gene

No data available for DME Specific Peptides for MAGEA12 Gene

Domains for MAGEA12 Gene

Protein Domains for MAGEA12 Gene

Suggested Antigen Peptide Sequences for MAGEA12 Gene

Graphical View of Domain Structure for InterPro Entry

P43365

UniProtKB/Swiss-Prot:

MAGAC_HUMAN :
  • P43365
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEA12: view

No data available for Gene Families for MAGEA12 Gene

Function for MAGEA12 Gene

Molecular function for MAGEA12 Gene

GENATLAS Biochemistry: human melanoma antigen,family A,member 12,expressed in melanoma,testis
UniProtKB/Swiss-Prot Function: Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.

Gene Ontology (GO) - Molecular Function for MAGEA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MAGEA12: view

Phenotypes for MAGEA12 Gene

GenomeRNAi human phenotypes for MAGEA12:
genes like me logo Genes that share phenotypes with MAGEA12: view

Animal Model Products

CRISPR Products

miRNA for MAGEA12 Gene

miRTarBase miRNAs that target MAGEA12

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAGEA12 Gene

Localization for MAGEA12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEA12 Gene COMPARTMENTS Subcellular localization image for MAGEA12 gene
Compartment Confidence
cytosol 2
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAGEA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MAGEA12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAGEA12 Gene

Pathways for MAGEA12 Gene

SuperPathways for MAGEA12 Gene

No Data Available

Interacting Proteins for MAGEA12 Gene

Gene Ontology (GO) - Biological Process for MAGEA12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MAGEA12: view

No data available for Pathways by source for MAGEA12 Gene

Transcripts for MAGEA12 Gene

Unigene Clusters for MAGEA12 Gene

Melanoma antigen family A, 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAGEA12

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA12 Gene

No ASD Table

Relevant External Links for MAGEA12 Gene

GeneLoc Exon Structure for
MAGEA12
ECgene alternative splicing isoforms for
MAGEA12

Expression for MAGEA12 Gene

mRNA expression in normal human tissues for MAGEA12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEA12 Gene

This gene is overexpressed in Testis (24.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEA12 Gene

SOURCE GeneReport for Unigene cluster for MAGEA12 Gene Hs.169246

mRNA Expression by UniProt/SwissProt for MAGEA12 Gene

P43365-MAGAC_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes
genes like me logo Genes that share expressions with MAGEA12: view

In Situ Assay Products

Orthologs for MAGEA12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEA12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEA12 35
  • 99.04 (n)
  • 98.73 (a)
MAGEA12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 40 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia 1700080O16Rik 36
  • 38 (a)
ManyToMany
3830417A13Rik 36
  • 38 (a)
ManyToMany
Magea1 36
  • 38 (a)
ManyToMany
Magea10 36
  • 40 (a)
ManyToMany
Magea2 36
  • 37 (a)
ManyToMany
Magea3 36
  • 38 (a)
ManyToMany
Magea4 36
  • 38 (a)
ManyToMany
Magea5 36
  • 38 (a)
ManyToMany
Magea6 36
  • 39 (a)
ManyToMany
Magea8 36
  • 38 (a)
ManyToMany
Species with no ortholog for MAGEA12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA12 Gene

ENSEMBL:
Gene Tree for MAGEA12 (if available)
TreeFam:
Gene Tree for MAGEA12 (if available)

Paralogs for MAGEA12 Gene

Pseudogenes.org Pseudogenes for MAGEA12 Gene

genes like me logo Genes that share paralogs with MAGEA12: view

Variants for MAGEA12 Gene

Sequence variations from dbSNP and Humsavar for MAGEA12 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_053498 -

Structural Variations from Database of Genomic Variants (DGV) for MAGEA12 Gene

Variant ID Type Subtype PubMed ID
dgv2493e1 CNV Complex 17122850

Relevant External Links for MAGEA12 Gene

HapMap Linkage Disequilibrium report
MAGEA12
Locus Specific Mutation Databases (LSDB)
MAGEA12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA12 Gene

Disorders for MAGEA12 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MAGEA12 Gene including...

Search for MAGEA12 Gene in MalaCards »
genes like me logo Genes that share disorders with MAGEA12: view

No data available for UniProtKB/Swiss-Prot for MAGEA12 Gene

Publications for MAGEA12 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Cloning and analysis of MAGE-1-related genes. (PMID: 8037761) Ding M. … Fenton R.G. (Biochem. Biophys. Res. Commun. 1994) 3 4
  3. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner U.C. … Poustka A. (Genomics 1995) 2 3
  4. Comparative genome sequence analysis of the Bpa/Str region in mouse and man. (PMID: 10854409) Mallon A.-M. … Brown S.D.M. (Genome Res. 2000) 3 4
  5. MAGE-12 and MAGE-6 are frequently expressed in malignant melanoma. (PMID: 10890380) Gibbs P. … Cebon J.S. (Melanoma Res. 2000) 3

Products for MAGEA12 Gene

Sources for MAGEA12 Gene

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