MAGEA12 Gene
protein-coding GIFtS: 50
GCID: GC0XM151899
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|
melanoma antigen family A, 12
(Previous symbol: MAGE12)
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Aliases
for MAGEA12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family A, 121 2 | | MAGE-12 Antigen2 3 | | MAGE121 2 3 5 | | MAGE12F Antigen2 3 | | CT1.121 2 3 | | Cancer/Testis Antigen Family 1, Member 122 | | Cancer/Testis Antigen 1.122 3 | | Melanoma-Associated Antigen 122 |
Export aliases for MAGEA12 gene to outside databasesPrevious GC identifers: GC0XM146239 GC0XM148556 GC0XM149647 GC0XM150516 GC0XM151476 GC0XM151628 GC0XM151649 GC0XM140701 |
Summaries
for MAGEA12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEA12:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequenceidentity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggestingthat the existence of this gene family enables the same function to be expressed under different transcriptionalcontrols. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditarydisorders, such as dyskeratosis congenita. Multiple alternatively spliced variants, encoding the same protein, havebeen identified. (provided by RefSeq, Oct 2009)
UniProtKB/Swiss-Prot: MAGAC_HUMAN, P43365Function: Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability inmelanoma cell lines
Gene Wiki entry for MAGEA12
|
Genomic Views
for MAGEA12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEA12 gene promoter:
TBP p53 POU2F1 POU2F1a TFIID MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEA12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28MAGEA12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM151899: view genomic region
(about GC identifiers)
Start:
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151,899,293 bp from pter |
End:
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151,903,184 bp from pter |
Size:
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3,892 bases |
Orientation:
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minus strand |
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Proteins
for MAGEA12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGAC_HUMAN, P43365 (See
protein sequence)Recommended Name: Melanoma-associated antigen 12 Size: 314 amino acids; 34836 Da
Secondary accessions: Q9NSD3Explore the universe of human proteins at neXtProt for MAGEA12: NX_P43365
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P43365
MAGEA12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001159858.1 NP_001159859.1 NP_005358.2
ENSEMBL proteins: ENSP00000350592 ENSP00000377447 ENSP00000377478
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
MAGEA12 for ontologies About GeneDecksing
MAGEA12 Antibody Products:
Assay Products for MAGEA12: |
Protein
Domains /
Families
for MAGEA12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEA12 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P43365ProtoNet protein and cluster: P43365 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGAC_HUMAN, P43365Similarity: Contains 1 MAGE domain |
Function
for MAGEA12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAGAC_HUMAN, P43365Function: Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability inmelanoma cell lines Genatlas biochemistry entry for MAGEA12:human melanoma antigen,family A,member 12,expressed in melanoma,testis
Clone
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
MAGEA12 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MAGEA12:
|
Pathways & Interactions
for MAGEA12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEA12
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for MAGEA12 (P433652, 3 ENSP000003505924) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
MAGEA12 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAGEA12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEA12
Search CenterWatch for drugs/clinical trials and news about MAGEA12 / MAGAC
|
Transcripts
for MAGEA12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEA12 gene (3 alternative transcripts): NM_001166386.1 NM_001166387.1 NM_005367.5 Unigene Cluster for MAGEA12: Melanoma antigen family A, 12 Hs.169246 [show with all ESTs]Unigene Representative Sequence: NM_0011663863 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357916(uc004fgc.3) ENST00000393869(uc022chi.1) ENST00000393900(uc010ntp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA12 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MAGEA12 (NM_005367) | | | DNA2.0 Custom Codon Optimized Gene
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Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEA12
Browse OriGene validated miRNA SYBR primer pairs
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Additional cDNA sequence: AK314168.1 BC003408.2 BC013171.1 BC098146.1 BT007108.1 CR541775.1 NR_073432.1 4 DOTS entries: DT.441466 DT.95280682 DT.95248475 DT.91772013 24/183 AceView cDNA sequences (see all 183): BE279401 CD557117 BC063681 AW673548 BG575302 BM762699 BX106621 BC003408 BU622519 NM_175743 BI090658 AI222439 CA429655 BE901056 BQ226610 CA441190 BE795782 BM760598 BC000340 BF791772 CR541774 BM999965 BM781931 AA905896
GeneLoc Exon Structure
|
Expression
for MAGEA12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEA12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATACCTGGA
About this image
See MAGEA12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEA12
SOURCE GeneReport for Unigene cluster: Hs.169246
UniProtKB/Swiss-Prot: MAGAC_HUMAN, P43365Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma,lung carcinoma and breast carcinoma, but not in normal tissues except for testes
SABiosciences Custom PCR Arrays for MAGEA12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEA12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MAGEA12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEA12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEA12 |
Orthologs
for MAGEA12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEA12 gene from 3/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
33(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
25(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
19(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEA12 (if available)
TreeFam Gene Tree for MAGEA12 (if available) |
Paralogs
for MAGEA12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEA12 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGEA82 MAGED22 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12 MAGED12
- MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2 MAGEE22
- MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/37 SIMAP similar genes for MAGEA12 using alignment to 2 protein entries: MAGAC_HUMAN (see all proteins)
(see all similar genes):MAGEA2B MAGEA6 MAGEA2 MAGEA3 MAGEA5 MAGEA4
MAGEA1 MAGEA8 MAGEA11 MAGEA9 MAGEA9B MAGEA13P
MAGEB16 MAGEH1 MAGEA10 MAGEC3 MAGEB5 MAGED1
MAGEA12 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MAGEA12
PGOHUM00000241296
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Genomic Variants
for MAGEA12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEA12 (151899293 - 151903184 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAGEA12
1 CNV: 3273
Locus Specific Mutation Databases (LSDB): MAGEA12
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEA12 |
|
Disorders
/ Diseases
for MAGEA12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEA12 for disorders About GeneDecksing
OMIM gene information: 300177
OMIM disorders: --
8  diseases for MAGEA12: About MalaCardsdyskeratosis congenita dyskeratosis melanoma oral squamous cell carcinoma
squamous cell carcinoma lung carcinoma carcinoma breast carcinoma
Export disorders for MAGEA12 gene to outside databases
|
Publications
for MAGEA12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEA12 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MAGEA12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Comparative genome sequence analysis of the Bpa/Str region in mouse and man. (PubMed id 10854409)1, 2 Mallon A.-M....Brown S.D.M. (2000)
- The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
- Cloning and analysis of MAGE-1-related genes. (PubMed id 8037761)1, 2 Ding M.... Fenton R.G. (1994)
- Sequence and expression pattern of the human MAGE2 gene. (PubMed id 8276455)1, 2 De Smet C....Boon T. (1994)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Expression of MAGE-A12 in oral squamous cell carcinoma. (PubMed id 18057533)1 Mollaoglu N....Ries J. (2008)
- Expression of melanoma-associated antigens in oral squamous cell carcinoma. (PubMed id 18197853)1 Ries J....Nkenke E. (2008)
- MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines. (PubMed id 17942928)2 Yang B.... Longley B.J. (2007)
|
External Searches for MAGEA12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEA12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEA12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEA12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEA12 gene:
Search GeneIP for patents involving MAGEA12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEA12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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