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MAGEA11 Gene

protein-coding   GIFtS: 57

GC0XM148578
melanoma antigen family A, 11
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MAGE11)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CT1.11 1, 2, 3
MAGE-11 1, 2
MAGE11 2, 3, 5
MAGEA-11 1, 2
MGC10511 1, 2
OTTHUMP00000024217 2
Descriptions
Cancer/testis antigen 1.11 3
MAGE-11 antigen 2, 3
cancer/testis antigen family 1, member 11 2
melanoma antigen family A, 11 2
melanoma-associated antigen 11 2
External Ids
HGNC: 67981
Entrez Gene: 41102
UniProtKB: P433643
Ensembl: ENSG000001852477
Search outside databases for aliases for MAGEA11 gene

Previous GC identifers: GC0XU990099 GC0XM146658 GC0XM147473 GC0XM148473

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for MAGEA11:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50
to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show
considerable variability, suggesting that the existence of this gene family enables the same
function to be expressed under different transcriptional controls. The MAGEA genes are clustered
at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as
dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for
this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364
Function: Acts as androgen receptor co-regulator that increases androgen receptor activity by
modulating the receptors interdomain interaction. May play a role in embryonal development and
tumor transformation or aspects of tumor progression

Gene Wiki entry for MAGEA11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MAGEA11 gene  

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MAGEA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM148578:     (about GC identifiers)

Start:
148,575,477 bp from pter
End:
148,604,507 bp from pter
Size:
29,031 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011681.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364 (See protein sequence)
Recommended Name: Melanoma-associated antigen 11  
Size: 429 amino acids; 48129 Da
Subcellular location: Nucleus. Cytoplasm
Sequence caution: Sequence=AAA68870.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5ETU4 Q6ZRZ5
Alternative splicing: 2 isoforms:  P43364-1   P43364-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001011544.1  NP_005357.2  


    ENSEMBL proteins: 
    ENSP00000328177 ENSP00000347358 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (MAGEA11)
    Human Recombinant Proteins from Abnova (MAGEA11)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for MAGEA11: 
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    Novus Biologicals Antibodies for MAGEA11

    Assays for MAGEA11: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR002190 MAGE


       GeneDecks  MAGEA11 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P43364

    ProtoNet protein and cluster: P43364

    1 Blocks protein family: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364
    Similarity: Contains 1 MAGE domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MAGEA11)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MAGEA11)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005366

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    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001011544
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001011544
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001011544 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005366

    UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364
    Function: Acts as androgen receptor co-regulator that increases androgen receptor activity by
    modulating the receptors interdomain interaction. May play a role in embryonal development and
    tumor transformation or aspects of tumor progression

    Genatlas biochemistry entry for MAGEA11:
    human melanoma antigen,family A,member 11,expressed in testis

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI16189514
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  MAGEA11 


    5/59 Interacting proteins for MAGEA11 (P433641, 2 ENSP000003281773) via UniProtKB, MINT, and/or STRING (see all 59 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2D4AQ9H7881, 2EBI-739552, EBI-747035 MINT-67945 EBI-739552, EBI-747035 MINT-67945
    CLUAP1Q96AJ11EBI-739552, EBI-739780
    TCEA2Q155601EBI-739552, EBI-710310
    SH2D4AQ9H7881, 2EBI-739552, EBI-747035 MINT-67945 EBI-739552, EBI-747035 MINT-67945
    ACMSDQ8TDX52MINT-67614
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for MAGEA11

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MAGEA11)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MAGEA11)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005366

                  Sigma-Aldrich siRNA and siRNA Panels for MAGEA11  
                         Sigma-Aldrich shRNA for MAGEA11  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001011544  NM_005366  

    REFSEQ mRNAs for MAGEA11 gene (2 alternative transcripts): 

    NM_001011544.1   NM_005366.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001011544  NM_005366  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001011544
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001011544
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001011544 

    Additional cDNA sequence: 

    AK127849.1 AY747607.1 BC004479.2 

    3 DOTS entries:

    DT.40111795  DT.101980120  DT.100660948 

    24/29 AceView cDNA sequences (see all 29 ):

    BQ224197 BQ212898 BQ013976 CD244394 CA432574 AI690425 BQ011399 BX337921 
    BQ013273 CB145694 BX337920 AI915285 AK127849 BE894801 BX371712 BI092645 
    BU622427 BE730295 BQ013935 BQ010568 NM_005366 BC004479 BU753959 BU630798 

    highest scoring ESTs for MAGEA11:

    BG183996 U10686 AK127849 AI690425 AI691089 BC004479 BE392039 BE730295 BE894801 BI092645 

    Unigene Cluster for MAGEA11:

    Melanoma antigen family A, 11
    Hs.670252  [show with all ESTs]
    Unigene Representative Sequence: AK127849


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000333104  ENST00000355220  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    MAGEA11 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for MAGEA11

    1 / 2 / 3

    3 probe-sets matching MAGEA11 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    34574_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U10686 0.20 1.00 0.72 1

    210503_at2, 3 U133-A 2 1.00 0.91 -- -- BC004479 0.40 0.67 0.55 1

    210503_at2 U133Plus2 2 1.00 0.91 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTGTTTTGCT

    SOURCE GeneReport for Unigene cluster: Hs.670252

    Expression variation in blood from EXPOLDB for MAGEA11

    UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364
    Tissue specificity: Expressed in tumors of several types, such as melanoma, head and neck squamous
    cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate,
    cancerous prostate, breast and adrenal tissue

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for MAGEA11 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    MAGEA111   -- melanoma antigen family A, 11 97.52(n)
    96.63(a)
    465899  XM_521299.2  XP_521299.2 
    cow
    (Bos taurus)
    MAGEA111   -- melanoma antigen family A, 11 69.87(n)
    52.88(a)
    519325  XM_597541.3  XP_597541.2 
    rat
    (Rattus norvegicus)
    Magea81   -- melanoma antigen, family A, 8 63.57(n)
    45.02(a)
    302638  XM_228890.1  XP_228890.1 
    mouse
    (Mus musculus)
    Magea81   -- melanoma antigen, family A, 8 62.76(n)
    46.55(a)
    17144  NM_020020.3  NP_064404.1 
    About this table        Species with no ortholog for MAGEA11

    ENSEMBL Gene Tree for MAGEA11
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for MAGEA11 gene
    MAGEA32  MAGEA2B2  MAGEA82  MAGEA122  MAGEA92  MAGEA9B2  MAGEA42  MAGEA12  
    MAGEA102  MAGEA62  MAGEA22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/124 NCBI SNPs in MAGEA11 are shown (see all 124 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 29)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs66413521,2
    A,C,F,H148581595(+) TTTATT/CTACTG 2 -- ng31 int116Minor allele frequency- C:0.39EU EA WA NS NA 839
    rs101263161,2
    A,C,F,H148575735(+) CCAAAG/AGGAAA 2 -- ut31 ese38Minor allele frequency- A:0.32EU EA WA 732
    rs48931241,2
    A,C,F,H148582655(+) TCACAC/TGTCTC 2 -- int1 ng314Minor allele frequency- T:0.23EU EA WA 418
    rs22330491,2
    C,F,H148576686(-) GGGAGC/ACTATC 2 R/S mis18Minor allele frequency- A:0.01EU EA WA 624
    --
    rs66413531,2
    A,C148581801(+) TCCCCC/GCCAAT 2 -- int1 ng31 trp30--------
    --
    rs125560821,2
    C148604714(+) tgaacA/Ggctga 1 -- ng310--------
    --
    rs66413501,2
    H148576546(+) TGACTC/GGATAC 2 R/P mis1 ese34Minor allele frequency- G:0.00EU EA WA 406
    rs74710611,2
    C148575315(+) CTACTC/TTGGAA 2 -- ng510--------
    --
    rs22330501,2
    A,C148576182(-) CTCCTC/TACCCA 2 L/L syn1 ese30--------
    --
    rs120133431,2
    A,C,F,H148599085(+) atttgA/Ctatgg 1 -- int14Minor allele frequency- C:0.47EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for MAGEA11 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 300344

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/14 PubMed articles for MAGEA11 gene (see all 14 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4110 HGNC: 6798 AceView: MAGEA11 Ensembl:ENSG00000185247 euGenes: HUgn4110
    ECgene: MAGEA11 H-InvDB: MAGEA11
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for MAGEA11 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for MAGEA11:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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