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MAGEA11 Gene

protein-coding   GIFtS: 51
GCID: GC0XP148769

Melanoma Antigen Family A, 11


(Previous symbol: MAGE11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Melanoma Antigen Family A, 111 2     Cancer/Testis Antigen Family 11
MAGE111 2 3 5     Member 111
MAGE-11 Antigen1 2 3     MAGE-112
Melanoma-Associated Antigen 111 2     MAGEA-112
Cancer/Testis Antigen 1.112 3     Cancer/Testis Antigen Family 1, Member 112
CT1.112 3     

External Ids:    HGNC: 67981   Entrez Gene: 41102   Ensembl: ENSG000001852477   OMIM: 3003445   UniProtKB: P433643   

Export aliases for MAGEA11 gene to outside databases

Previous GC identifers: GC0XU990099 GC0XM146658 GC0XM147473 GC0XM148473 GC0XM148578 GC0XM137720


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAGEA11 Gene:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence
identity to each other. The promoters and first exons of the MAGEA genes show considerable variability,
suggesting that the existence of this gene family enables the same function to be expressed under different
transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated
in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAGEA11 Gene:
MAGEA11 (melanoma antigen family A, 11) is a protein-coding gene. Diseases associated with MAGEA11 include dyskeratosis congenita, and melanoma. An important paralog of this gene is MAGEC2.

UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364
Function: Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the
receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects
of tumor progression

Gene Wiki entry for MAGEA11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MAGEA11 gene promoter:
         TBP   c-Fos   Pbx1a   AP-1   TFIID   MyoD   c-Jun   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGEA11 promoter sequence
   Search Chromatin IP Primers for MAGEA11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGEA11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MAGEA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEA11 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP148769:  view genomic region     (about GC identifiers)

Start:
148,769,894 bp from pter      End:
148,798,928 bp from pter
Size:
29,035 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364 (See protein sequence)
Recommended Name: Melanoma-associated antigen 11  
Size: 429 amino acids; 48129 Da
Sequence caution: Sequence=AAA68870.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5ETU4 Q6ZRZ5
Alternative splicing: 2 isoforms:  P43364-1   P43364-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAGEA11: NX_P43364

Explore proteomics data for MAGEA11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAGEA11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001011544.1  NP_005357.2  

    ENSEMBL proteins: 
     ENSP00000391496   ENSP00000347358   ENSP00000328177  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry P43364

    ProtoNet protein and cluster: P43364

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364
    Similarity: Contains 1 MAGE domain


    MAGEA11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAGAB_HUMAN, P43364
    Function: Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the
    receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects
    of tumor progression

         Genatlas biochemistry entry for MAGEA11:
    human melanoma antigen,family A,member 11,expressed in testis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    MAGEA11 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAGEA11
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    miRTarBase miRNAs that target MAGEA11:
    hsa-mir-26b-5p (MIRT030319)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAGAB_HUMAN, P43364: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    MAGEA11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAGEA11
    Interactions:

        GeneGlobe Interaction Network for MAGEA11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAGEA11 (P433641, 2, 3 ENSP000003473584) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2D4AQ9H7881, 2, 3, ENSP000002658074EBI-739552,EBI-747035 MINT-67945 I2D: score=6 STRING: ENSP00000265807
    ENSG00000237071P143732, 3, ENSP000004052294MINT-67923 I2D: score=5 STRING: ENSP00000405229
    ENSG00000215641P143732, 3MINT-67923 I2D: score=5 
    ENSG00000229006P143732, 3MINT-67923 I2D: score=5 
    ENSG00000234495P143732, 3MINT-67923 I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAGEA11 (MAGAB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAGEA11 gene (2 alternative transcripts): 
    NM_001011544.1  NM_005366.4  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412632 ENST00000518694(uc004fdq.3) ENST00000355220 ENST00000333104(uc004fdr.3)

    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MAGEA11
      QuantiFast Probe-based Assays in human, mouse, rat MAGEA11

    Selected AceView cDNA sequences (see all 29):

    BQ224197 BQ212898 AI690425 AW129513 CA432574 BQ013273 BQ010568 BX337921 
    BU622427 NM_005366 BQ011399 BE730295 AI915285 BE894801 BX337920 BQ013935 
    BQ013976 BX371712 BU753959 BU621062 BC004479 CD244394 AK127849 CB145694 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAGEA11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTTTGCT
    MAGEA11 Expression
    About this image

    MAGEA11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAGEA11 Protein Expression

    UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364
    Tissue specificity: Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma,
    lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal
    tissue

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MAGEA11 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Magea41 melanoma antigen, family A, 4 61.37(n)
    43.24(a)
      17140  NM_020280.2  NP_064676.2 


    ENSEMBL Gene Tree for MAGEA11 (if available)
    TreeFam Gene Tree for MAGEA11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAGEA11 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEB42  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGED12  
    MAGEA22  MAGEA32  MAGEB22  NDN2  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  
    MAGEA102  MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  NDNL22  MAGEF12  
    Selected SIMAP similar genes for MAGEA11 using alignment to 3 protein entries:     MAGAB_HUMAN (see all proteins) (see all similar genes):
    MAGEA8    MAGEC1    MAGEC4    MAGEA12    MAGEA4    MAGEA9B
    MAGEA2B    MAGEA3    MAGEA9    MAGEA6    MAGEA2    MAGEA1
    MAGEB18    MAGEB6    MAGEC2    MAGEE1    MAGEA5    NDNL2

    MAGEA11 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MAGEA11
    PGOHUM00000241593 PGOHUM00000242072


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAGEA11 (see all 536)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809601421,2
    --148721675(+) GAATGA/GATGTC 1 -- us2k10--------
    rs1859867711,2
    --148721840(+) CATGAC/TTTTGT 1 -- us2k10--------
    rs1454931371,2
    --148722129(+) CCTCCC/TGCATG 1 -- us2k10--------
    rs1921139121,2
    --148722368(+) ACCACA/GCACAC 1 -- us2k10--------
    rs1439792601,2
    --148722519(+) AATCTC/GGGAAC 1 -- us2k10--------
    rs1466463201,2
    --148722572(+) GGCCCA/GGTAGC 1 -- us2k10--------
    rs1414188341,2
    C--148722653(+) GAAGAA/CTTCTG 1 -- us2k10--------
    rs1840117281,2
    --148722681(+) ATTTCG/TCCTCA 1 -- us2k10--------
    rs1884203331,2
    --148722957(+) TTACTG/TGTTTA 1 -- us2k10--------
    rs117959641,2
    C,H--148722989(-) tttcaC/Ttgtgt 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAGEA11 (148769894 - 148798928 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MAGEA11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508000CNV Insertion20534489
    nsv510566CNV Loss20534489
    nsv525908CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): MAGEA11

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAGEA11
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGEA11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300344    OMIM disorders: --

    6 diseases for MAGEA11:    About MalaCards
    dyskeratosis congenita    melanoma    hypoxia    prostate cancer
    squamous cell carcinoma    prostatitis


    MAGEA11 for disorders           About GeneDecksing


    Export disorders for MAGEA11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAGEA11 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with MAGEA11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction. (PubMed id 15684378)1, 2 Bai S.... Wilson E.M. (Mol. Cell. Biol. 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (Genomics 1995)
    5. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (Immunogenetics 1994)
    6. Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation. (PubMed id 18048459)1, 9 Bai S....Wilson E.M. (Mol. Hum. Reprod. 2008)
    7. Proto-oncogene activity of melanoma antigen-A11 (MAGE-A11) regulates retinoblastoma-related p107 and E2F1 proteins. (PubMed id 23853093)1 Su S....Wilson E.M. (J. Biol. Chem. 2013)
    8. Melanoma antigen-A11 (MAGE-A11) enhances transcriptional activity by linking androgen receptor dimers. (PubMed id 23172223)1 Minges J.T....Wilson E.M. (J. Biol. Chem. 2013)
    9. Androgen receptor exon 1 mutation causes androgen insensitivity by creating phosphorylation site and inhibiting melanoma antigen-A11 activation of NH2- and carboxyl-terminal interaction-dependent transactivation. (PubMed id 22334658)1 Lagarde W.H....Wilson E.M. (J. Biol. Chem. 2012)
    10. Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation. (PubMed id 22891251)1 Su S....Wilson E.M. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4110 HGNC: 6798 AceView: MAGEA11 Ensembl:ENSG00000185247 euGenes: HUgn4110
    ECgene: MAGEA11 H-InvDB: MAGEA11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAGEA11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEA11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAGEA11 gene:
    Search GeneIP for patents involving MAGEA11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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