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Aliases for MAGEA11 Gene

Aliases for MAGEA11 Gene

  • MAGE Family Member A11 2 3 5
  • MAGE-11 Antigen 2 3 4
  • Melanoma Antigen Family A11 2 3
  • Cancer/Testis Antigen 1.11 3 4
  • MAGE11 3 4
  • CT1.11 3 4
  • Cancer/Testis Antigen Family 1, Member 11 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma-Associated Antigen 11 2
  • Melanoma Antigen Family A, 11 3
  • Member 11 2
  • MAGEA-11 3
  • MAGE-11 3

External Ids for MAGEA11 Gene

Previous HGNC Symbols for MAGEA11 Gene

  • MAGE11

Previous GeneCards Identifiers for MAGEA11 Gene

  • GC0XU990099
  • GC0XM146658
  • GC0XM147473
  • GC0XM148473
  • GC0XM148578
  • GC0XP148769
  • GC0XM137720

Summaries for MAGEA11 Gene

Entrez Gene Summary for MAGEA11 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA11 Gene

MAGEA11 (MAGE Family Member A11) is a Protein Coding gene. Diseases associated with MAGEA11 include Melanoma and Dyskeratosis Congenita. An important paralog of this gene is MAGEC3.

UniProtKB/Swiss-Prot for MAGEA11 Gene

  • Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.

Gene Wiki entry for MAGEA11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA11 Gene

Genomics for MAGEA11 Gene

Regulatory Elements for MAGEA11 Gene

Enhancers for MAGEA11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAGEA11 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAGEA11 Gene

149,688,198 bp from pter
149,717,268 bp from pter
29,071 bases
Plus strand

Genomic View for MAGEA11 Gene

Genes around MAGEA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA11 Gene

Proteins for MAGEA11 Gene

  • Protein details for MAGEA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen 11
    Protein Accession:
    Secondary Accessions:
    • Q5ETU4
    • Q6ZRZ5

    Protein attributes for MAGEA11 Gene

    429 amino acids
    Molecular mass:
    48129 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA68870.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MAGEA11 Gene


neXtProt entry for MAGEA11 Gene

Proteomics data for MAGEA11 Gene at MOPED

Post-translational modifications for MAGEA11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEA11 Gene

No data available for DME Specific Peptides for MAGEA11 Gene

Domains & Families for MAGEA11 Gene

Gene Families for MAGEA11 Gene

Protein Domains for MAGEA11 Gene


Suggested Antigen Peptide Sequences for MAGEA11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 MAGE domain.
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEA11: view

Function for MAGEA11 Gene

Molecular function for MAGEA11 Gene

GENATLAS Biochemistry:
human melanoma antigen,family A,member 11,expressed in testis
UniProtKB/Swiss-Prot Function:
Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.

Phenotypes for MAGEA11 Gene

genes like me logo Genes that share phenotypes with MAGEA11: view

Animal Model Products

CRISPR Products

miRNA for MAGEA11 Gene

miRTarBase miRNAs that target MAGEA11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAGEA11 Gene

Localization for MAGEA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEA11 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for MAGEA11 Gene COMPARTMENTS Subcellular localization image for MAGEA11 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAGEA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MAGEA11: view

Pathways & Interactions for MAGEA11 Gene

SuperPathways for MAGEA11 Gene

No Data Available

SIGNOR curated interactions for MAGEA11 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAGEA11 Gene


No data available for Pathways by source for MAGEA11 Gene

Drugs & Compounds for MAGEA11 Gene

No Compound Related Data Available

Transcripts for MAGEA11 Gene

Unigene Clusters for MAGEA11 Gene

Melanoma antigen family A, 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA11 Gene

No ASD Table

Relevant External Links for MAGEA11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEA11 Gene

mRNA expression in normal human tissues for MAGEA11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEA11 Gene

This gene is overexpressed in Testis (x44.0).

Protein differential expression in normal tissues from HIPED for MAGEA11 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEA11 Gene

SOURCE GeneReport for Unigene cluster for MAGEA11 Gene Hs.670252

mRNA Expression by UniProt/SwissProt for MAGEA11 Gene

Tissue specificity: Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue.
genes like me logo Genes that share expression patterns with MAGEA11: view

Protein tissue co-expression partners for MAGEA11 Gene

Primer Products

Orthologs for MAGEA11 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA11 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Magea4 35
  • 61.37 (n)
  • 43.24 (a)
Magea4 16
1700080O16Rik 36
  • 44 (a)
3830417A13Rik 36
  • 44 (a)
Magea1 36
  • 41 (a)
Magea10 36
  • 43 (a)
Magea2 36
  • 40 (a)
Magea3 36
  • 41 (a)
Magea4 36
  • 40 (a)
Magea5 36
  • 42 (a)
Magea6 36
  • 42 (a)
Magea8 36
  • 41 (a)
(Pan troglodytes)
Mammalia MAGEA11 35
  • 99.41 (n)
  • 98.98 (a)
MAGEA11 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Magea4 35
  • 64.04 (n)
  • 47.26 (a)
Species with no ortholog for MAGEA11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA11 Gene

Gene Tree for MAGEA11 (if available)
Gene Tree for MAGEA11 (if available)

Paralogs for MAGEA11 Gene Pseudogenes for MAGEA11 Gene

genes like me logo Genes that share paralogs with MAGEA11: view

Variants for MAGEA11 Gene

Sequence variations from dbSNP and Humsavar for MAGEA11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2233049 - 149,716,059(+) GGGAG(A/C/T)CTATC reference, synonymous-codon, missense
rs916016 -- 149,688,525(-) GTTCC(C/T)GAAGC intron-variant
rs1303779 -- 149,699,260(+) TTGGG(C/G)AGATC intron-variant
rs1304308 -- 149,695,386(+) ATAAA(C/T)TAGAT intron-variant
rs1970766 -- 149,713,293(+) GGCAC(A/G)GTGGC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MAGEA11 Gene

Variant ID Type Subtype PubMed ID
nsv525908 CNV Gain 19592680
nsv510566 CNV Loss 20534489
nsv508000 CNV Insertion 20534489

Variation tolerance for MAGEA11 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAGEA11 Gene

Disorders for MAGEA11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAGEA11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
dyskeratosis congenita
  • revesz syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEA11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAGEA11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA11 Gene

Publications for MAGEA11 Gene

  1. Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction. (PMID: 15684378) Bai S. … Wilson E.M. (Mol. Cell. Biol. 2005) 3 4 67
  2. Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation. (PMID: 18048459) Bai S. … Wilson E.M. (Mol. Hum. Reprod. 2008) 3 23
  3. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner U.C. … Poustka A. (Genomics 1995) 2 3
  4. Post-translational Down-regulation of Melanoma Antigen-A11 (MAGE-A11) by Human p14-ARF Tumor Suppressor. (PMID: 26330556) Minges J.T. … Wilson E.M. (J. Biol. Chem. 2015) 3
  5. Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism. (PMID: 24316396) Hou S.Y. … Shan B.E. (Arch. Med. Res. 2014) 3

Products for MAGEA11 Gene

Sources for MAGEA11 Gene