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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAGEA11 Gene

protein-coding   GIFtS: 54
GCID: GC0XP148769

Melanoma Antigen Family A, 11


(Previous symbol: MAGE11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Melanoma Antigen Family A, 111 2     Cancer/Testis Antigen Family 11
MAGE111 2 3 5     Member 111
MAGE-11 Antigen1 2 3     MAGE-112
Melanoma-Associated Antigen 111 2     MAGEA-112
Cancer/Testis Antigen 1.112 3     Cancer/Testis Antigen Family 1, Member 112
CT1.112 3     

External Ids:    HGNC: 67981   Entrez Gene: 41102   Ensembl: ENSG000001852477   OMIM: 3003445   UniProtKB: P433643   

Export aliases for MAGEA11 gene to outside databases

Previous GC identifers: GC0XU990099 GC0XM146658 GC0XM147473 GC0XM148473 GC0XM148578 GC0XM137720


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAGEA11 Gene:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence
identity to each other. The promoters and first exons of the MAGEA genes show considerable variability,
suggesting that the existence of this gene family enables the same function to be expressed under different
transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated
in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAGEA11 Gene: 
MAGEA11 (melanoma antigen family A, 11) is a protein-coding gene. Diseases associated with MAGEA11 include dyskeratosis congenita, and melanoma. GO annotations related to this gene include protein binding. An important paralog of this gene is MAGEC2.

UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364
Function: Acts as androgen receptor co-regulator that increases androgen receptor activity by modulating the
receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects
of tumor progression

Gene Wiki entry for MAGEA11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011681.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGEA11 gene promoter:
         TBP   c-Fos   Pbx1a   AP-1   TFIID   MyoD   c-Jun   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGEA11 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAGEA11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MAGEA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEA11 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP148769:  view genomic region     (about GC identifiers)

Start:
148,769,894 bp from pter      End:
148,798,928 bp from pter
Size:
29,035 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364 (See protein sequence)
Recommended Name: Melanoma-associated antigen 11  
Size: 429 amino acids; 48129 Da
Subcellular location: Nucleus. Cytoplasm
Sequence caution: Sequence=AAA68870.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5ETU4 Q6ZRZ5
Alternative splicing: 2 isoforms:  P43364-1   P43364-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAGEA11: NX_P43364

Explore proteomics data for MAGEA11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P43364

  • MAGEA11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAGEA11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001011544.1  NP_005357.2  

    ENSEMBL proteins: 
     ENSP00000391496   ENSP00000347358   ENSP00000328177  

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    Cloud-Clone Corp. Proteins for MAGEA11 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    MAGEA11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry P43364

    ProtoNet protein and cluster: P43364

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364
    Similarity: Contains 1 MAGE domain


    MAGEA11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAGAB_HUMAN, P43364
    Function: Acts as androgen receptor co-regulator that increases androgen receptor activity by modulating the
    receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects
    of tumor progression

         Genatlas biochemistry entry for MAGEA11:
    human melanoma antigen,family A,member 11,expressed in testis

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    MAGEA11 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAGEA11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/121 Interacting proteins for MAGEA11 (P433641, 2, 3 ENSP000003473584) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2D4AQ9H7881, 2, 3, ENSP000002658074EBI-739552,EBI-747035 MINT-67945 I2D: score=6 STRING: ENSP00000265807
    ENSG00000237071P143732, 3, ENSP000004052294MINT-67923 I2D: score=5 STRING: ENSP00000405229
    ENSG00000215641P143732, 3MINT-67923 I2D: score=5 
    ENSG00000229006P143732, 3MINT-67923 I2D: score=5 
    ENSG00000234495P143732, 3MINT-67923 I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAGEA11 (MAGAB)

    Search CenterWatch for drugs/clinical trials and news about MAGEA11 / MAGAB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAGEA11 gene (2 alternative transcripts): 
    NM_001011544.1  NM_005366.4  

    Unigene Cluster for MAGEA11:

    Melanoma antigen family A, 11
    Hs.670252  [show with all ESTs]
    Unigene Representative Sequence: AK127849
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412632 ENST00000518694(uc004fdq.3) ENST00000355220 ENST00000333104(uc004fdr.3)

    miRNA
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of MAGEA11 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAGEA11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAGEA11

    Additional mRNA sequence: 

    AK127849.1 AY747607.1 BC004479.2 

    3 DOTS entries:

    DT.40111795  DT.100660948  DT.101980120 

    24/29 AceView cDNA sequences (see all 29):

    BQ212898 BQ224197 BU621062 BX337921 BQ013935 BX371712 AW129513 BE894801 
    BU630798 AI915285 BQ013273 BQ011399 NM_005366 BQ010568 AK127849 AI690425 
    BU753959 CD244394 BX337920 BI092645 BE730295 BC004479 BU622427 BQ013976 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAGEA11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTTTGCT
    MAGEA11 Expression
    About this image


    See MAGEA11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAGEA11

    SOURCE GeneReport for Unigene cluster: Hs.670252

    UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364
    Tissue specificity: Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma,
    lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal
    tissue

        SABiosciences Custom PCR Arrays for MAGEA11
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for MAGEA11 (if available)
    TreeFam Gene Tree for MAGEA11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAGEA11 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEB42  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGED12  
    MAGEA22  MAGEA32  MAGEB22  NDN2  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  
    MAGEA102  MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  NDNL22  MAGEF12  
    18/35 SIMAP similar genes for MAGEA11 using alignment to 3 protein entries:     MAGAB_HUMAN (see all proteins) (see all similar genes):
    MAGEA8    MAGEC1    MAGEC4    MAGEA12    MAGEA4    MAGEA9B
    MAGEA2B    MAGEA3    MAGEA9    MAGEA6    MAGEA2    MAGEA1
    MAGEB18    MAGEB6    MAGEC2    MAGEE1    MAGEA5    NDNL2

    MAGEA11 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MAGEA11
    PGOHUM00000241593 PGOHUM00000242072


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/536 SNPs in MAGEA11 are shown (see all 536)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809601421,2
    --148721675(+) GAATGA/GATGTC 1 -- us2k10--------
    rs1859867711,2
    --148721840(+) CATGAC/TTTTGT 1 -- us2k10--------
    rs1454931371,2
    --148722129(+) CCTCCC/TGCATG 1 -- us2k10--------
    rs1921139121,2
    --148722368(+) ACCACA/GCACAC 1 -- us2k10--------
    rs1439792601,2
    --148722519(+) AATCTC/GGGAAC 1 -- us2k10--------
    rs1466463201,2
    --148722572(+) GGCCCA/GGTAGC 1 -- us2k10--------
    rs1414188341,2
    C--148722653(+) GAAGAA/CTTCTG 1 -- us2k10--------
    rs1840117281,2
    --148722681(+) ATTTCG/TCCTCA 1 -- us2k10--------
    rs1884203331,2
    --148722957(+) TTACTG/TGTTTA 1 -- us2k10--------
    rs117959641,2
    C,H--148722989(-) tttcaC/Ttgtgt 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAGEA11 (148769894 - 148798928 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MAGEA11:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508000CNV Insertion20534489
    nsv510566CNV Loss20534489
    nsv525908CNV Gain19592680


    Locus Specific Mutation Databases (LSDB): MAGEA11
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300344    OMIM disorders: --

    6 diseases for MAGEA11:    About MalaCards
    dyskeratosis congenita    melanoma    hypoxia    prostate cancer
    squamous cell carcinoma    prostatitis


    MAGEA11 for disorders           About GeneDecksing


    Export disorders for MAGEA11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAGEA11 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with MAGEA11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction. (PubMed id 15684378)1, 2 Bai S.... Wilson E.M. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
    5. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (1994)
    6. Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation. (PubMed id 18048459)1, 9 Bai S....Wilson E.M. (2008)
    7. Melanoma antigen-A11 (MAGE-A11) enhances transcription al activity by linking androgen receptor dimers. (PubMed id 23172223)1 Minges J.T....Wilson E.M. (2013)
    8. Androgen receptor exon 1 mutation causes androgen inse nsitivity by creating phosphorylation site and inhibiting melanoma antigen-A11 a ctivation of NH2- and carboxyl-terminal interaction-dependent transactivation. (PubMed id 22334658)1 Lagarde W.H....Wilson E.M. (2012)
    9. Primate-specific melanoma antigen-A11 regulates isofor m-specific human progesterone receptor-B transactivation. (PubMed id 22891251)1 Su S....Wilson E.M. (2012)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4110 HGNC: 6798 AceView: MAGEA11 Ensembl:ENSG00000185247 euGenes: HUgn4110
    ECgene: MAGEA11 H-InvDB: MAGEA11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAGEA11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEA11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAGEA11 gene:
    Search GeneIP for patents involving MAGEA11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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