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Aliases for MAGEA11 Gene

Aliases for MAGEA11 Gene

  • Melanoma Antigen Family A11 2 3
  • MAGE-11 Antigen 2 3 4
  • MAGE11 3 4 6
  • Melanoma-Associated Antigen 11 2 3
  • Cancer/Testis Antigen 1.11 3 4
  • CT1.11 3 4
  • Cancer/Testis Antigen Family 1, Member 11 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma Antigen Family A, 11 3
  • Member 11 2
  • MAGEA-11 3
  • MAGE-11 3

External Ids for MAGEA11 Gene

Previous Symbols for MAGEA11 Gene

  • MAGE11

Summaries for MAGEA11 Gene

Entrez Gene Summary for MAGEA11 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA11 Gene

MAGEA11 (Melanoma Antigen Family A11) is a Protein Coding gene. Diseases associated with MAGEA11 include melanoma. An important paralog of this gene is MAGED1.

UniProtKB/Swiss-Prot for MAGEA11 Gene

  • Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.

Gene Wiki entry for MAGEA11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA11 Gene

Genomics for MAGEA11 Gene

Genomic Location for MAGEA11 Gene

Start:
149,688,228 bp from pter
End:
149,717,268 bp from pter
Size:
29,041 bases
Orientation:
Plus strand

Genomic View for MAGEA11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAGEA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA11 Gene

Regulatory Elements for MAGEA11 Gene

Proteins for MAGEA11 Gene

  • Protein details for MAGEA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43364-MAGAB_HUMAN
    Recommended name:
    Melanoma-associated antigen 11
    Protein Accession:
    P43364
    Secondary Accessions:
    • Q5ETU4
    • Q6ZRZ5

    Protein attributes for MAGEA11 Gene

    Size:
    429 amino acids
    Molecular mass:
    48129 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA68870.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MAGEA11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAGEA11 Gene

Proteomics data for MAGEA11 Gene at MOPED

Post-translational modifications for MAGEA11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEA11 Gene

No data available for DME Specific Peptides for MAGEA11 Gene

Domains for MAGEA11 Gene

Protein Domains for MAGEA11 Gene

UniProtKB/Swiss-Prot:

MAGAB_HUMAN
Domain:
  • Contains 1 MAGE domain.:
    • P43364
genes like me logo Genes that share domains with MAGEA11: view

No data available for Gene Families for MAGEA11 Gene

Function for MAGEA11 Gene

Molecular function for MAGEA11 Gene

GENATLAS Biochemistry: human melanoma antigen,family A,member 11,expressed in testis
UniProtKB/Swiss-Prot Function: Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.

Gene Ontology (GO) - Molecular Function for MAGEA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with MAGEA11: view

miRNA for MAGEA11 Gene

miRTarBase miRNAs that target MAGEA11

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAGEA11 Gene

Localization for MAGEA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEA11 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEA11 Gene COMPARTMENTS Subcellular localization image for MAGEA11 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAGEA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MAGEA11: view

Pathways for MAGEA11 Gene

SuperPathways for MAGEA11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEA11 Gene

None

No data available for Pathways by source for MAGEA11 Gene

Transcripts for MAGEA11 Gene

Unigene Clusters for MAGEA11 Gene

Melanoma antigen family A, 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA11 Gene

No ASD Table

Relevant External Links for MAGEA11 Gene

GeneLoc Exon Structure for
MAGEA11
ECgene alternative splicing isoforms for
MAGEA11

Expression for MAGEA11 Gene

mRNA expression in normal human tissues for MAGEA11 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEA11 Gene

This gene is overexpressed in Testis (44.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEA11 Gene

SOURCE GeneReport for Unigene cluster for MAGEA11 Gene Hs.670252

mRNA Expression by UniProt/SwissProt for MAGEA11 Gene

P43364-MAGAB_HUMAN
Tissue specificity: Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue.
genes like me logo Genes that share expressions with MAGEA11: view

Orthologs for MAGEA11 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEA11 36
  • 99.41 (n)
  • 98.98 (a)
MAGEA11 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700080O16Rik 37
  • 44 (a)
ManyToMany
3830417A13Rik 37
  • 44 (a)
ManyToMany
Magea1 37
  • 41 (a)
ManyToMany
Magea10 37
  • 43 (a)
ManyToMany
Magea2 37
  • 40 (a)
ManyToMany
Magea3 37
  • 41 (a)
ManyToMany
Magea4 36
  • 61.37 (n)
  • 43.24 (a)
Magea4 37
  • 40 (a)
ManyToMany
Magea5 37
  • 42 (a)
ManyToMany
Magea6 37
  • 42 (a)
ManyToMany
Magea8 37
  • 41 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Magea4 36
  • 64.04 (n)
  • 47.26 (a)
Species with no ortholog for MAGEA11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA11 Gene

ENSEMBL:
Gene Tree for MAGEA11 (if available)
TreeFam:
Gene Tree for MAGEA11 (if available)

Paralogs for MAGEA11 Gene

Pseudogenes.org Pseudogenes for MAGEA11 Gene

genes like me logo Genes that share paralogs with MAGEA11: view

Variants for MAGEA11 Gene

Sequence variations from dbSNP and Humsavar for MAGEA11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs916016 -- 149,688,525(-) GTTCC(C/T)GAAGC intron-variant
rs1303779 -- 149,699,260(+) TTGGG(C/G)AGATC intron-variant
rs1304308 -- 149,695,386(+) ATAAA(C/T)TAGAT intron-variant
rs1970766 -- 149,713,293(+) GGCAC(A/G)GTGGC intron-variant
rs2156978 -- 149,707,816(+) atcct(A/C/G/T)ttatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEA11 Gene

Variant ID Type Subtype PubMed ID
nsv525908 CNV Gain 19592680
nsv510566 CNV Loss 20534489
nsv508000 CNV Insertion 20534489

Relevant External Links for MAGEA11 Gene

HapMap Linkage Disequilibrium report
MAGEA11
Locus Specific Mutation Databases (LSDB)
MAGEA11

Disorders for MAGEA11 Gene

(1) MalaCards Diseases for MAGEA11 Gene

Search for MAGEA11 Gene in MalaCards »
genes like me logo Genes that share disorders with MAGEA11: view

No data available for UniProtKB/Swiss-Prot for MAGEA11 Gene

Publications for MAGEA11 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction. (PMID: 15684378) Bai S. … Wilson E.M. (Mol. Cell. Biol. 2005) 3 4
  4. Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation. (PMID: 18048459) Bai S. … Wilson E.M. (Mol. Hum. Reprod. 2008) 3 23
  5. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PMID: 7927540) De Plaen E. … Boon T. (Immunogenetics 1994) 3 4

Products for MAGEA11 Gene

Sources for MAGEA11 Gene

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