MAGEA11 Gene
protein-coding GIFtS: 54
GCID: GC0XP148769
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melanoma antigen family A, 11
(Previous symbol: MAGE11)
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Aliases
for MAGEA11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family A, 111 2 | | Cancer/Testis Antigen 1.112 3 | | MAGE111 2 3 5 | | MAGE-11 Antigen2 3 | | CT1.111 2 3 | | MGC105111 | | MAGE-111 2 | | Cancer/Testis Antigen Family 1, Member 112 | | MAGEA-111 2 | | Melanoma-Associated Antigen 112 |
Export aliases for MAGEA11 gene to outside databasesPrevious GC identifers: GC0XU990099 GC0XM146658 GC0XM147473 GC0XM148473 GC0XM148578 GC0XM137720 |
Summaries
for MAGEA11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEA11:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequenceidentity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggestingthat the existence of this gene family enables the same function to be expressed under different transcriptionalcontrols. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditarydisorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found forthis gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364Function: Acts as androgen receptor co-regulator that increases androgen receptor activity by modulating the receptorsinterdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumorprogression
Gene Wiki entry for MAGEA11
|
Genomic Views
for MAGEA11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011681.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEA11 gene promoter:
TBP c-Fos Pbx1a AP-1 TFIID MyoD c-Jun Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEA11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28MAGEA11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP148769: view genomic region
(about GC identifiers)
Start:
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148,769,894 bp from pter |
End:
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148,798,928 bp from pter |
Size:
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29,035 bases |
Orientation:
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plus strand |
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Proteins
for MAGEA11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364 (See
protein sequence)Recommended Name: Melanoma-associated antigen 11 Size: 429 amino acids; 48129 Da
Subcellular location: Nucleus. Cytoplasm
Sequence caution: Sequence=AAA68870.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5ETU4 Q6ZRZ5Alternative splicing: 2 isoforms: P43364-1 P43364-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MAGEA11: NX_P43364
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P43364
MAGEA11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001011544.1 NP_005357.2
ENSEMBL proteins: ENSP00000391496 ENSP00000347358 ENSP00000328177
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MAGEA11 for ontologies About GeneDecksing
MAGEA11 Antibody Products:
Assay Products for MAGEA11: |
Protein
Domains /
Families
for MAGEA11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEA11 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P43364ProtoNet protein and cluster: P43364 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364Similarity: Contains 1 MAGE domain |
Function
for MAGEA11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364Function: Acts as androgen receptor co-regulator that increases androgen receptor activity by modulating the receptorsinterdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumorprogression Genatlas biochemistry entry for MAGEA11:human melanoma antigen,family A,member 11,expressed in testis
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA11 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA11 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
MAGEA11 for ontologies About GeneDecksing
|
Pathways & Interactions
for MAGEA11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAGEA11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/118 Interacting proteins for MAGEA11 (P433641, 2, 3 ENSP000003473584) via UniProtKB, MINT, STRING, and/or I2D (see all 118)| Interactant | Interaction Details |
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| GeneCard | External ID(s) |
|---|
| SH2D4A | Q9H7881, 2, 3, ENSP000002658074 | EBI-739552,EBI-2558037 MINT-67945 I2D:
score=6 STRING: ENSP00000265807 | | TRMT1 | Q9NXH92, 3, ENSP000003503524 | MINT-67392 I2D:
score=6 STRING: ENSP00000350352 | | AKR1C3 | P423302, 3, ENSP000003699274 | MINT-66510 I2D:
score=5 STRING: ENSP00000369927 | | ARHGAP29 | Q52LW32, 3, ENSP000002605264 | MINT-67052 I2D:
score=5 STRING: ENSP00000260526 | | CCDC14 | Q49A882, 3, ENSP000003868664 | MINT-68001 I2D:
score=5 STRING: ENSP00000386866 |
About this table
|
Drugs & Compounds
for MAGEA11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEA11
Search CenterWatch for drugs/clinical trials and news about MAGEA11 / MAGAB
|
Transcripts
for MAGEA11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEA11 gene (2 alternative transcripts): NM_001011544.1 NM_005366.4 Unigene Cluster for MAGEA11: Melanoma antigen family A, 11 Hs.670252 [show with all ESTs]Unigene Representative Sequence: AK1278494 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000412632 ENST00000518694(uc004fdq.3) ENST00000355220 ENST00000333104(uc004fdr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA11 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MAGEA11 (NM_001011544) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAGEA11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEA11 |
Additional cDNA sequence: AK127849.1 AY747607.1 BC004479.2 3 DOTS entries: DT.40111795 DT.100660948 DT.101980120 24/29 AceView cDNA sequences (see all 29): BQ224197 BQ212898 CA432574 CD244394 BU622427 BU621062 BU630798 BQ013976 BX337921 BU753959 BC004479 BQ013935 BI092645 NM_005366 CB145694 BX371712 BE730295 AW129513 BE894801 AK127849 BQ013273 BX337920 AI915285 AI690425
GeneLoc Exon Structure
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Expression
for MAGEA11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEA11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTTTTGCT
About this image
See MAGEA11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEA11
SOURCE GeneReport for Unigene cluster: Hs.670252
UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364Tissue specificity: Expressed in tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lungcarcinoma and breast carcinoma. Expressed in testis, ovary, prostate, cancerous prostate, breast and adrenal tissue
SABiosciences Custom PCR Arrays for MAGEA11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEA11
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA11 |
Orthologs
for MAGEA11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEA11 gene from 3/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
37(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
28(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
20(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEA11 (if available)
TreeFam Gene Tree for MAGEA11 (if available) |
Paralogs
for MAGEA11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEA11 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGEA82 MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12
- MAGED12 MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2
- MAGEE22 MAGEA42 MAGEA12 MAGEA102 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22
- TRO2 NDNL22 MAGEF12
18/35 SIMAP similar genes for MAGEA11 using alignment to 3 protein entries: MAGAB_HUMAN (see all proteins)
(see all similar genes):MAGEA8 MAGEC1 MAGEC4 MAGEA12 MAGEA4 MAGEA9B
MAGEA2B MAGEA3 MAGEA9 MAGEA6 MAGEA2 MAGEA1
MAGEB18 MAGEB6 MAGEC2 MAGEE1 MAGEA5 NDNL2
MAGEA11 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for MAGEA11
PGOHUM00000241593 PGOHUM00000242072
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Genomic Variants
for MAGEA11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEA11 (148769894 - 148798928 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAGEA11
1 CNV: 4177
Locus Specific Mutation Databases (LSDB): MAGEA11
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEA11 |
|
Disorders
/ Diseases
for MAGEA11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEA11 for disorders About GeneDecksing
OMIM gene information: 300344
OMIM disorders: --
10  diseases for MAGEA11: About MalaCardsdyskeratosis congenita dyskeratosis melanoma squamous cell carcinoma
lung carcinoma breast carcinoma carcinoma prostate cancer
hypoxia prostatitis
Export disorders for MAGEA11 gene to outside databases
|
Publications
for MAGEA11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEA11 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with MAGEA11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction. (PubMed id 15684378)1, 2 Bai S.... Wilson E.M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
- Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (1994)
- Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation. (PubMed id 18048459)1, 9 Bai S....Wilson E.M. (2008)
- Androgen receptor exon 1 mutation causes androgen inse nsitivity by creating phosphorylation site and inhibiting melanoma antigen-A11 a ctivation of NH2- and carboxyl-terminal interaction-dependent transactivation. (PubMed id 22334658)1 Lagarde W.H....Wilson E.M. (2012)
- Primate-specific melanoma antigen-A11 regulates isofor m-specific human progesterone receptor-B transactivation. (PubMed id 22891251)1 Su S....Wilson E.M. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Gain in transcriptional activity by primate-specific coevolution of melanoma antigen-A11 and its interaction site in androgen recept or. (PubMed id 21730049)1 Liu Q....Wilson E.M. (2011)
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External Searches for MAGEA11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEA11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEA11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEA11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEA11 gene:
Search GeneIP for patents involving MAGEA11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEA11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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