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Aliases & Descriptions for MAGEA11
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CT1.11 1 , 2 , 3 MAGE-11 1 , 2 MAGE11 2 , 3 , 5 MAGEA-11 1 , 2 MGC10511 1 , 2 OTTHUMP00000024217 2
Descriptions Cancer/testis antigen 1.11 3 MAGE-11 antigen 2 , 3 cancer/testis antigen family 1, member 11 2 melanoma antigen family A, 11 2 melanoma-associated antigen 11 2
Search outside databases for aliases for MAGEA11 genePrevious GC identifers: GC0XU990099 GC0XM146658 GC0XM147473 GC0XM148473
Summaries for MAGEA11 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for MAGEA11 : This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes showconsiderable variability, suggesting that the existence of this gene family enables the samefunction to be expressed under different transcriptional controls. The MAGEA genes are clusteredat chromosomal location Xq28. They have been implicated in some hereditary disorders, such asdyskeratosis congenita. Two transcript variants encoding different isoforms have been found forthis gene. [provided by RefSeq] UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364 Function : Acts as androgen receptor co-regulator that increases androgen receptor activity bymodulating the receptors interdomain interaction. May play a role in embryonal development andtumor transformation or aspects of tumor progression
Gene Wiki entry for MAGEA11
Genomic Location for MAGEA11
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MAGEA11 gene Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28 MAGEA11 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM148578:
(about GC identifiers )
Start:
148,575,477 bp from pter
End:
148,604,507 bp from pter
Size:
29,031 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000023.9 NT_011681.15 Proteins for MAGEA11
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364 (See
protein sequence )Recommended Name: Melanoma-associated antigen 11 Size : 429 amino acids; 48129 Da
Subcellular location : Nucleus. Cytoplasm
Sequence caution : Sequence=AAA68870.1; Type=Erroneous gene model prediction;
Secondary accessions : Q5ETU4 Q6ZRZ5Alternative splicing : 2 isoforms : P43364-1 P43364-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001011544.1 NP_005357.2 ENSEMBL proteins: ENSP00000328177 ENSP00000347358 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for MAGEA11: Assays for MAGEA11:
Protein
Domains/ Families for MAGEA11(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P43364 ProtoNet protein and cluster: P43364
1 Blocks protein family : IPB002190 MAGE protein UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364 Similarity : Contains 1 MAGE domain
Gene Function for MAGEA11
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005366 Applied Biosystems Silencer ® siRNAs for MAGEA11 Sigma-Aldrich siRNA and siRNA Panels for MAGEA11 Sigma-Aldrich shRNA for MAGEA11 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001011544                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001011544                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001011544  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005366 UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364 Function : Acts as androgen receptor co-regulator that increases androgen receptor activity bymodulating the receptors interdomain interaction. May play a role in embryonal development andtumor transformation or aspects of tumor progression
Genatlas biochemistry entry for MAGEA11 :human melanoma antigen,family A,member 11,expressed in testis 1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for MAGEA11
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for MAGEA11 5/59 Interacting proteins for MAGEA11 (P43364 1 , 2 ENSP00000328177 3 ) via UniProtKB, MINT, and/or STRING (see all 59
)About this table
Drugs & Compounds for MAGEA11 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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PharmGKB )
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Browse Tocris compounds for MAGEA11
Transcripts for MAGEA11(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005366 Sigma-Aldrich siRNA and siRNA Panels for MAGEA11 Sigma-Aldrich shRNA for MAGEA11 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001011544 NM_005366
REFSEQ mRNAs for MAGEA11 gene (2 alternative transcripts): NM_001011544.1 NM_005366.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001011544 NM_005366
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001011544                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001011544                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001011544  
Additional cDNA sequence: AK127849.1 AY747607.1 BC004479.2
3 DOTS entries : DT.40111795 DT.101980120 DT.100660948
24/29 AceView cDNA sequences (see all 29
):BQ224197 BQ212898 BQ013976 CD244394 CA432574 AI690425 BQ011399 BX337921 BQ013273 CB145694 BX337920 AI915285 AK127849 BE894801 BX371712 BI092645 BU622427 BE730295 BQ013935 BQ010568 NM_005366 BC004479 BU753959 BU630798
highest scoring ESTs for MAGEA11 :BG183996 U10686 AK127849 AI690425 AI691089 BC004479 BE392039 BE730295 BE894801 BI092645
Unigene Cluster for MAGEA11: Melanoma antigen family A, 11 Hs.670252 [show with all ESTs ] Unigene Representative Sequence: AK127849 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000333104
ENST00000355220
Expression for MAGEA11
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MAGEA11 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MAGEA11 1 / 2 / 3
3 probe-sets matching MAGEA11 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TTGTTTTGCTSOURCE GeneReport for Unigene cluster: Hs.670252 Expression variation in blood from EXPOLDB for MAGEA11
UniProtKB/Swiss-Prot: MAGAB_HUMAN, P43364 Tissue specificity : Expressed in tumors of several types, such as melanoma, head and neck squamouscell carcinoma, lung carcinoma and breast carcinoma. Expressed in testis, ovary, prostate,cancerous prostate, breast and adrenal tissue
Orthologs for MAGEA11
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for MAGEA11 gene from 4 species
About this table Species with no ortholog for MAGEA11 ENSEMBL Gene Tree for MAGEA11 Paralogs for MAGEA11 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MAGEA11 gene MAGEA3 2 MAGEA2B 2 MAGEA8 2 MAGEA12 2 MAGEA9 2 MAGEA9B 2 MAGEA4 2 MAGEA1 2 MAGEA10 2 MAGEA6 2 MAGEA2 2
SNPs/Variants for MAGEA11 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MAGEA11 (up to first 250kb)
Disorders & Mutations for MAGEA11
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 300344
Medical News for MAGEA11 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MAGEA11 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/14 PubMed articles for MAGEA11 gene (see all 14
): Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction. (PubMed id 15684378) 3, 4 Bai S.... Wilson E.M. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766) 2, 3 Rogner U.C....Poustka A. (1995) Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540) 3, 4 De Plaen E.... Boon T. (1994) Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation. (PubMed id 18048459) 1, 3 Bai S....Wilson E.M. (2008) Increased expression of androgen receptor coregulator MAGE-11 in prostate cancer by DNA hypomethylation and cyclic AMP. (PubMed id 19372581) 3 Karpf A.R....Wilson E.M. (2009) Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. (PubMed id 19147576) 3 Aprelikova O....Niederhuber J. (2009) Epidermal-growth-factor-dependent phosphorylation and ubiquitinylation of MAGE-11 regulates its interaction with the androgen receptor. (PubMed id 18212060) 3 Bai S. and Wilson E.M. (2008)
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Genome Databases showing MAGEA11
(According to
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and/or
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Other Databases showing MAGEA11
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Specialized Databases showing MAGEA11 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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