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Aliases & Descriptions for MAGEA10
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CT1.10 1 , 2 , 3 MAGE10 2 , 3 , 5 MGC10599 1 , 2 OTTHUMP00000025894 2
Descriptions Cancer/testis antigen 1.10 3 MAGE-10 antigen 2 , 3 cancer/testis antigen family 1, member 10 2 melanoma antigen family A, 10 2 melanoma-associated antigen 10 2
Search outside databases for aliases for MAGEA10 genePrevious GC identifers: GC0XM145637 GC0XM147960 GC0XM149050 GC0XM149920 GC0XM150973
Summaries for MAGEA10 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for MAGEA10 : This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes showconsiderable variability, suggesting that the existence of this gene family enables the samefunction to be expressed under different transcriptional controls. The MAGEA genes are clusteredat chromosomal location Xq28. They have been implicated in some hereditary disorders, such asdyskeratosis congenita. Two transcript variants encoding the same protein have been found for thisgene. [provided by RefSeq] UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363 Function : Not known, though may play a role in embryonal development and tumor transformation oraspects of tumor progression
Genomic Location for MAGEA10
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the MAGEA10 gene Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28 MAGEA10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM151052:
(about GC identifiers )
Start:
151,053,547 bp from pter
End:
151,057,681 bp from pter
Size:
4,135 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000023.9 NT_011726.13 Proteins for MAGEA10
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363 (See
protein sequence )Recommended Name: Melanoma-associated antigen 10 Size : 369 amino acids; 40767 Da
REFSEQ proteins (2 alternative transcripts):
NP_001011543.1 NP_066386.1 ENSEMBL proteins: ENSP00000359347 ENSP00000244096 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for MAGEA10: Assays for MAGEA10:
Protein
Domains/ Families for MAGEA10(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P43363 ProtoNet protein and cluster: P43363
1 Blocks protein family : IPB002190 MAGE protein UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363 Similarity : Contains 1 MAGE domain
Gene Function for MAGEA10
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
Q-PCR Products
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001011543 Applied Biosystems Silencer ® siRNAs for MAGEA10 Sigma-Aldrich siRNA for MAGEA10 Sigma-Aldrich shRNA for MAGEA10 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001011543                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001011543                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001011543  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_021048 UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363 Function : Not known, though may play a role in embryonal development and tumor transformation oraspects of tumor progression
Genatlas biochemistry entry for MAGEA10 :human melanoma antigen,family A,member 10,expressed in placenta,melanoma and testis Pathways & Interactions for MAGEA10
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Interacting protein for MAGEA10 (ENSP00000244096 3 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for MAGEA10 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for MAGEA10
Transcripts for MAGEA10(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001011543 Sigma-Aldrich siRNA for MAGEA10 Sigma-Aldrich shRNA for MAGEA10 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001011543 NM_021048
REFSEQ mRNAs for MAGEA10 gene (2 alternative transcripts): NM_001011543.1 NM_021048.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001011543 NM_021048
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001011543                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001011543                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001011543  
Additional cDNA sequence: AK314161.1 AY522506.1 AY531264.1 BC004105.2 CR622868.1
4 DOTS entries : DT.86849784 DT.91676023 DT.97836077 DT.100746182
24/48 AceView cDNA sequences (see all 48
):AI142010 BG477105 BQ217649 BG477436 AY531264 BX109673 CB158974 BE277360 BG477980 CR622868 BX335540 BX097006 BE277068 BE730450 BG282169 BG478456 CD109866 R23725 BX335541 BM458898 BC004105 BU167137 BE389926 BG478664
highest scoring ESTs for MAGEA10 :BC004105 BE277068 BE277360 BE389926 BE730450 BF792982 BG282169 BG397037 BG478456 BG478664
Unigene Cluster for MAGEA10: Melanoma antigen family A, 10 Hs.18048 [show with all ESTs ] Unigene Representative Sequence: NM_001011543 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA10 ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 SP1 :                   SP2 :             -       SP3 :           -   -       SP4 :                  
About this scheme ECgene alternative splicing isoforms for MAGEA10 2 Ensembl transcripts including schematic representations : ENST00000370323
ENST00000244096
Expression for MAGEA10
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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MAGEA10 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for MAGEA10 1 / 2 / 3
3 probe-sets matching MAGEA10 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ATTTTACTCASOURCE GeneReport for Unigene cluster: Hs.18048 Expression variation in blood from EXPOLDB for MAGEA10
UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363 Tissue specificity : Expressed in many tumors of several types, such as melanoma, head and necksquamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except fortestes and placenta
Orthologs for MAGEA10
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for MAGEA10 gene from 5 species
About this table Species with no ortholog for MAGEA10 ENSEMBL Gene Tree for MAGEA10 Paralogs for MAGEA10 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for MAGEA10 gene MAGEA3 2 MAGEA2B 2 MAGEA8 2 MAGEA12 2 MAGEA9 2 MAGEA9B 2 MAGEA4 2 MAGEA11 2 MAGEA1 2 MAGEA6 2 MAGEA2 2 Pseudogenes 2 related pseudogenes
SNPs/Variants for MAGEA10 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for MAGEA10 (up to first 250kb)
Disorders & Mutations for MAGEA10
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 300343 2 Novoseek disease relationships for MAGEA10 gene
About this table
Medical News for MAGEA10 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for MAGEA10 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for MAGEA10 gene : The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766) 2, 3 Rogner U.C....Poustka A. (1995) Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540) 3, 4 De Plaen E.... Boon T. (1994) Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants. (PubMed id 15355897) 1, 3 Lin J....Beer D.G. (2004) cDNA and protein characterization of human MAGE-10. (PubMed id 10446460) 1, 3 Rimoldi D....Cerottini J.C. (1999) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) MAGE-A protein and MAGE-A10 gene expressions in liver metastasis in patients with stomach cancer. (PubMed id 18594524) 1 Suzuki S....Tajiri T. (2008) Quantitative evaluation of the expression of MAGE genes in tumors by limiting dilution of cDNA libraries. (PubMed id 10521804) 1 Serrano A....Boon T. (1999) CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational difference analysis. (PubMed id 10699956) 1 Gure A.O.... Chen Y.-T. (2000)
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Genome Databases showing MAGEA10
(According to
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miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing MAGEA10
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Specialized Databases showing MAGEA10 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for MAGEA10 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
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