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MAGEA10 Gene

protein-coding   GIFtS: 54

GC0XM151052
melanoma antigen family A, 10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MAGE10)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CT1.10 1, 2, 3
MAGE10 2, 3, 5
MGC10599 1, 2
OTTHUMP00000025894 2
Descriptions
Cancer/testis antigen 1.10 3
MAGE-10 antigen 2, 3
cancer/testis antigen family 1, member 10 2
melanoma antigen family A, 10 2
melanoma-associated antigen 10 2
External Ids
HGNC: 67971
Entrez Gene: 41092
UniProtKB: P433633
Ensembl: ENSG000001242607
Search outside databases for aliases for MAGEA10 gene

Previous GC identifers: GC0XM145637 GC0XM147960 GC0XM149050 GC0XM149920 GC0XM150973

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAGEA10:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50
to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show
considerable variability, suggesting that the existence of this gene family enables the same
function to be expressed under different transcriptional controls. The MAGEA genes are clustered
at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as
dyskeratosis congenita. Two transcript variants encoding the same protein have been found for this
gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363
Function: Not known, though may play a role in embryonal development and tumor transformation or
aspects of tumor progression

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MAGEA10 gene  

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MAGEA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM151052:     (about GC identifiers)

Start:
151,053,547 bp from pter
End:
151,057,681 bp from pter
Size:
4,135 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011726.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363 (See protein sequence)
Recommended Name: Melanoma-associated antigen 10  
Size: 369 amino acids; 40767 Da

REFSEQ proteins (2 alternative transcripts): 
NP_001011543.1  NP_066386.1  


ENSEMBL proteins: 
ENSP00000359347 ENSP00000244096 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (MAGEA10)
Human Recombinant Proteins from Abnova (MAGEA10)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for MAGEA10: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (MAGEA10), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (MAGEA10)
Search Novus for antibodies for MAGEA10

Assays for MAGEA10: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR002190 MAGE


   GeneDecks  MAGEA10 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P43363

ProtoNet protein and cluster: P43363

1 Blocks protein family: IPB002190 MAGE protein

UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363
Similarity: Contains 1 MAGE domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (MAGEA10)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001011543

              Applied Biosystems Silencer® siRNAs for MAGEA10

              Sigma-Aldrich siRNA for MAGEA10  
                     Sigma-Aldrich shRNA for MAGEA10  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for MAGEA10
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001011543
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001011543
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001011543 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_021048

UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363
Function: Not known, though may play a role in embryonal development and tumor transformation or
aspects of tumor progression

Genatlas biochemistry entry for MAGEA10:
human melanoma antigen,family A,member 10,expressed in placenta,melanoma and testis
(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



1 Interacting protein for MAGEA10 (ENSP000002440963) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
BAGE5ENSP000003355283STRING (score=.722)
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MAGEA10

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (MAGEA10)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001011543

              Sigma-Aldrich siRNA for MAGEA10  
                     Sigma-Aldrich shRNA for MAGEA10  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001011543  NM_021048  

REFSEQ mRNAs for MAGEA10 gene (2 alternative transcripts): 

NM_001011543.1   NM_021048.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001011543  NM_021048  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001011543
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001011543
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001011543 

Additional cDNA sequence: 

AK314161.1 AY522506.1 AY531264.1 BC004105.2 CR622868.1 

4 DOTS entries:

DT.86849784  DT.91676023  DT.97836077  DT.100746182 

24/48 AceView cDNA sequences (see all 48 ):

AI142010 BG477105 BQ217649 BG477436 AY531264 BX109673 CB158974 BE277360 
BG477980 CR622868 BX335540 BX097006 BE277068 BE730450 BG282169 BG478456 
CD109866 R23725 BX335541 BM458898 BC004105 BU167137 BE389926 BG478664 

highest scoring ESTs for MAGEA10:

BC004105 BE277068 BE277360 BE389926 BE730450 BF792982 BG282169 BG397037 BG478456 BG478664 

Unigene Cluster for MAGEA10:

Melanoma antigen family A, 10
Hs.18048  [show with all ESTs]
Unigene Representative Sequence: NM_001011543


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA10

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:                                                      
SP2:                                      -               
SP3:                                -     -               
SP4:                                                      

About this scheme

ECgene alternative splicing isoforms for MAGEA10

2 Ensembl transcripts including schematic representations:
ENST00000370323  ENST00000244096  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAGEA10 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for MAGEA10

1 / 2 / 3

3 probe-sets matching MAGEA10 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

35491_at2, 3 U95-A 2 1.00 0.94 1.00 1.00 U10685 0.20 1.00 0.72 1

210295_at2, 3 U133-A 3 1.00 0.91 -- -- BC004105 0.80 0.88 0.84 1

210295_at2 U133Plus2 3 1.00 0.91 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ATTTTACTCA

SOURCE GeneReport for Unigene cluster: Hs.18048

Expression variation in blood from EXPOLDB for MAGEA10

UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck
squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for
testes and placenta

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for MAGEA10 gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
MAGEA101   -- melanoma antigen family A, 10 70.81(n)
56.65(a)
492173  XM_549293.1  XP_549293.1 
chimpanzee
(Pan troglodytes)
MAGEA101   -- melanoma antigen family A, 10 99.27(n)
98.9(a)
465913  XM_521312.2  XP_521312.2 
cow
(Bos taurus)
MAGEA101   -- melanoma antigen family A, 10 72.14(n)
61.28(a)
509805  XM_586847.3  XP_586847.3 
rat
(Rattus norvegicus)
LOC3028451   -- similar to mage-k1 62.63(n)
47.14(a)
302845  NM_001013962.1  NP_001013984.1 
mouse
(Mus musculus)
Magea105
4930550L24Rik1
X5
melanoma antigen family A, 105
RIKEN cDNA 4930550L24 gene1
62.29(n)1
46.13(a)1
753521  NM_023774.21  NP_076263.11 
 AK1360645  AL8078165 
About this table        Species with no ortholog for MAGEA10

ENSEMBL Gene Tree for MAGEA10
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for MAGEA10 gene
MAGEA32  MAGEA2B2  MAGEA82  MAGEA122  MAGEA92  MAGEA9B2  MAGEA42  MAGEA112  
MAGEA12  MAGEA62  MAGEA22  

Pseudogenes
2 related pseudogenes


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/31 NCBI SNPs in MAGEA10 are shown (see all 31 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 21)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs2105851,2
A,C,F,H151054252(-) CATAAA/GAAATT 2 K/R mis1 ese310Minor allele frequency- G:0.05NA EA EU WA 892
rs2105871,2
A,C,F,H151053065(-) tttttT/Gttttt 2 -- ng51 trp34Minor allele frequency- G:0.01EU EA WA 418
rs2105861,2
A,C,F,H151054049(-) GCATAA/GTCTTC 2 I/V mis111Minor allele frequency- G:0.01NA PA EU EA WA 880
rs59698621,2
A,F,H151058479(+) TGTGGA/GGAGGT 2 -- ng314Minor allele frequency- G:0.03EU EA WA 418
rs1697621,2
C,F,H151057721(-) CGGGGA/GCCGGA 2 -- ng317Minor allele frequency- G:0.17NA PA EU EA WA 670
--
rs2105831,2
A,C151058081(-) CCACAA/GCCCTC 2 -- ng310--------
--
rs2105821,2
A,C151058088(-) ACCCCG/TACCAC 2 -- ng310--------
--
rs2105811,2
F,H151058321(-) AGGGAC/TCATCT 2 -- ng315Minor allele frequency- T:0.09EA WA NA 465
rs66275391,2
H151058503(+) GTTTAG/CCTGAT 2 -- ng314Minor allele frequency- C:0.00EU EA WA 418
rs2105841,2
A,C,F,H151055600(-) CTCAGA/GTCAAC 2 -- int18Minor allele frequency- G:0.27EU EA WA 628
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HapMap Linkage Disequilibrium images for MAGEA10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300343

2 Novoseek disease relationships for MAGEA10 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma 43.96 3 10446460 (2), 10521804 (1)
tumors 15.36 2 10446460 (1), 10521804 (1)
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(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

9 PubMed articles for MAGEA10 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4109 HGNC: 6797 AceView: MAGEA10andMAGEA5 Ensembl:ENSG00000124260 euGenes: HUgn4109
ECgene: MAGEA10 H-InvDB: MAGEA10
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for MAGEA10 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for MAGEA10:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for MAGEA10 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for MAGEA10

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