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MAGEA10 Gene

protein-coding   GIFtS: 52
GCID: GC0XM151302

Melanoma Antigen Family A, 10


(Previous symbol: MAGE10)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Melanoma Antigen Family A, 101 2     CT1.102 3
MAGE101 2 3 5     Cancer/Testis Antigen Family 11
MAGE-10 Antigen1 2 3     Member 101
Melanoma-Associated Antigen 101 2     Cancer/Testis Antigen Family 1, Member 102
Cancer/Testis Antigen 1.102 3     

External Ids:    HGNC: 67971   Entrez Gene: 41092   Ensembl: ENSG000001242607   OMIM: 3003435   UniProtKB: P433633   
ORGUL members:         

Export aliases for MAGEA10 gene to outside databases

Previous GC identifers: GC0XM145637 GC0XM147960 GC0XM149050 GC0XM149920 GC0XM150973 GC0XM151052 GC0XM140156


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAGEA10 Gene:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence
identity to each other. The promoters and first exons of the MAGEA genes show considerable variability,
suggesting that the existence of this gene family enables the same function to be expressed under different
transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated
in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript
variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A,
5 (MAGEA5) gene.(provided by RefSeq, Oct 2011)

GeneCards Summary for MAGEA10 Gene:
MAGEA10 (melanoma antigen family A, 10) is a protein-coding gene. Diseases associated with MAGEA10 include intrahepatic cholangiocarcinoma, and stomach cancer. An important paralog of this gene is MAGEC2.

UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363
Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor
progression




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011681.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAGEA10 gene promoter:
         NCX/Ncx   MEF-2A   POU2F1   GATA-6   Nkx6-1   FOXJ2 (long isoform)   POU2F1a   aMEF-2   FOXJ2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAGEA10 promoter sequence
   Search Chromatin IP Primers for MAGEA10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAGEA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MAGEA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEA10 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM151302:  view genomic region     (about GC identifiers)

Start:
151,301,782 bp from pter      End:
151,307,033 bp from pter
Size:
5,252 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363 (See protein sequence)
Recommended Name: Melanoma-associated antigen 10  
Size: 369 amino acids; 40780 Da

Explore the universe of human proteins at neXtProt for MAGEA10: NX_P43363

Explore proteomics data for MAGEA10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys269
  • Modification sites at PhosphoSitePlus

  • See MAGEA10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001011543.2  NP_001238757.1  NP_066386.2  

    ENSEMBL proteins: 
     ENSP00000359347   ENSP00000406161   ENSP00000391977   ENSP00000464160   ENSP00000462833  
     ENSP00000244096  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR021072 Melanoma_ass_antigen_N
     IPR002190 MAGE

    Graphical View of Domain Structure for InterPro Entry P43363

    ProtoNet protein and cluster: P43363

    1 Blocks protein domain: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363
    Similarity: Contains 1 MAGE domain


    MAGEA10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAGAA_HUMAN, P43363
    Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor
    progression

         Genatlas biochemistry entry for MAGEA10:
    human melanoma antigen,family A,member 10,expressed in placenta,melanoma and testis

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAGAA_HUMAN, P43363: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    MAGEA10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAGEA10
    Interactions:

        Search GeneGlobe Interaction Network for MAGEA10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MAGEA10 (ENSP000002440964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2F1ENSP000003455714STRING: ENSP00000345571
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAGEA10 (MAGAA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAGEA10 gene (3 alternative transcripts): 
    NM_001011543.2  NM_001251828.1  NM_021048.4  

    Unigene Cluster for MAGEA10:

    Melanoma antigen family A, 10
    Hs.18048  [show with all ESTs]
    Unigene Representative Sequence: NM_001011543
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370323(uc004ffk.3 uc004ffm.2 uc004ffl.3) ENST00000444834
    ENST00000427322 ENST00000583480 ENST00000579960 ENST00000244096
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MAGEA10
      QuantiFast Probe-based Assays in human, mouse, rat MAGEA10

    Additional mRNA sequence: 

    AK314161.1 AY310324.1 AY522506.1 AY531264.1 BC004105.2 

    7 DOTS entries:

    DT.86849784  DT.91676023  DT.95103326  DT.97836077  DT.100746182  DT.423199  DT.423198 

    Selected AceView cDNA sequences (see all 48):

    BE277360 BX335540 BX109673 BG477980 BG477105 AI142010 BG477436 AY531264 
    BQ217649 CB158974 CR622868 CD109866 BU167137 AI200443 BG282169 BX097006 
    AY310324 NM_021048 BE277068 BX335541 BG478664 R23725 BE730450 BG478456 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA10    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5
    SP1:                                                      
    SP2:                                      -               
    SP3:                                -     -               
    SP4:                                                      


    ECgene alternative splicing isoforms for MAGEA10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAGEA10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTACTCA
    MAGEA10 Expression
    About this image

    MAGEA10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAGEA10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.18048

    UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363
    Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell
    carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for spermatogonia, spermatocytes
    and placenta

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for MAGEA10 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Magea101 , 5 melanoma antigen family A, 101, 5 67.7(n)1
    55.28(a)1
      X (37.23 cM)5
    2368521  NM_001085506.11  NP_001078975.11 
     723818705 


    ENSEMBL Gene Tree for MAGEA10 (if available)
    TreeFam Gene Tree for MAGEA10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAGEA10 gene
    MAGEC22  MAGEA9B2  MAGEB52  MAGEB162  MAGEB12  MAGEB42  MAGEC12  MAGED42  
    MAGEA82  MAGED22  MAGEA122  MAGEA92  MAGEB172  MAGEB102  MAGEA62  MAGED12  
    MAGEA22  MAGEA32  MAGEB22  NDN2  MAGEB32  MAGED4B2  MAGEA42  MAGEA12  
    MAGEB182  MAGEA2B2  MAGEB62  MAGEL22  TRO2  MAGEA112  NDNL22  MAGEF12  
    Selected SIMAP similar genes for MAGEA10 using alignment to 5 protein entries:     MAGAA_HUMAN (see all proteins) (see all similar genes):
    MAGEC4    MAGEC1    MAGEC3    MAGEA9B    MAGEH1    MAGEB16
    MAGEA13P    NDNL2    TRO    MAGEA8    MAGEB1    MAGEB4
    MAGE-B1    MAGEA12    MAGEB18    MAGEB2    MAGEB5    MAGEC2

    MAGEA10 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for MAGEA10
    PGOHUM00000241578 PGOHUM00000241595 PGOHUM00000241689 PGOHUM00000241756 PGOHUM00000242044


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for MAGEA10    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830911871,2
    C--140162821(+) TATAAC/TATTTC 3 -- us2k10--------
    rs2105861,2,4
    ----see VAR_0534962 mis40--------
    rs2105851,2,4
    ----see VAR_0245282 mis40--------

    HapMap Linkage Disequilibrium report for MAGEA10 (151301782 - 151307033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MAGEA10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520971CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAGEA10
    DNA2.0 Custom Variant and Variant Library Synthesis for MAGEA10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300343    OMIM disorders: --

    11 diseases for MAGEA10:    
    About MalaCards
    intrahepatic cholangiocarcinoma    stomach cancer    dyskeratosis congenita    melanoma
    multiple myeloma    cholangiocarcinoma    myeloma    esophagitis
    adenocarcinoma    squamous cell carcinoma    breast cancer


    MAGEA10 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for MAGEA10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 43 3 10446460 (2), 10521804 (1)
    tumors 14.2 2 10446460 (1), 10521804 (1)


    Export disorders for MAGEA10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAGEA10 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with MAGEA10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies. (PubMed id 21710496)1, 2 Schultz-Thater E.... Spagnoli G.C. (Int. J. Cancer 2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (Genomics 1995)
    4. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (Immunogenetics 1994)
    5. Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants. (PubMed id 15355897)1, 9 Lin J....Beer D.G. (Clin. Cancer Res. 2004)
    6. cDNA and protein characterization of human MAGE-10. (PubMed id 10446460)1, 9 Rimoldi D....Cerottini J.C. (Int. J. Cancer 1999)
    7. High expression of MAGE-A10 cancer-testis antigen in triple-negative breast cancer. (PubMed id 22116775)1 Badovinac A8rnjeviA8 T....Nera A. . (Med. Oncol. 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4109 HGNC: 6797 AceView: MAGEA10andMAGEA5 Ensembl:ENSG00000124260 euGenes: HUgn4109
    ECgene: MAGEA10 H-InvDB: MAGEA10

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAGEA10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAGEA10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAGEA10 gene:
    Search GeneIP for patents involving MAGEA10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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