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Aliases for MAGEA10 Gene

Aliases for MAGEA10 Gene

  • MAGE Family Member A10 2 3 5
  • MAGE-10 Antigen 2 3 4
  • Cancer/Testis Antigen Family 1, Member 10 2 3
  • Melanoma-Associated Antigen 10 2 3
  • Melanoma Antigen Family A10 2 3
  • Cancer/Testis Antigen 1.10 3 4
  • MAGE10 3 4
  • CT1.10 3 4
  • Melanoma Antigen Family A, 10 3

External Ids for MAGEA10 Gene

Previous HGNC Symbols for MAGEA10 Gene

  • MAGE10

Previous GeneCards Identifiers for MAGEA10 Gene

  • GC0XM145637
  • GC0XM147960
  • GC0XM149050
  • GC0XM149920
  • GC0XM150973
  • GC0XM151052
  • GC0XM151302
  • GC0XM140156

Summaries for MAGEA10 Gene

Entrez Gene Summary for MAGEA10 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011]

GeneCards Summary for MAGEA10 Gene

MAGEA10 (MAGE Family Member A10) is a Protein Coding gene. Diseases associated with MAGEA10 include Melanoma and Dyskeratosis Congenita. An important paralog of this gene is MAGEA8.

UniProtKB/Swiss-Prot for MAGEA10 Gene

  • Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Additional gene information for MAGEA10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA10 Gene

Genomics for MAGEA10 Gene

GeneHancer (GH) Regulatory Elements for MAGEA10 Gene

Promoters and enhancers for MAGEA10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI152138 Promoter 0.6 EPDnew 550.8 +0.0 2 0.1 POLR2A ENSG00000266560 ENSG00000231937 MAGEA10 MAGEA10-MAGEA5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MAGEA10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MAGEA10 gene promoter:

Genomic Locations for MAGEA10 Gene

Genomic Locations for MAGEA10 Gene
5,269 bases
Minus strand

Genomic View for MAGEA10 Gene

Genes around MAGEA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA10 Gene

Proteins for MAGEA10 Gene

  • Protein details for MAGEA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Melanoma-associated antigen 10
    Protein Accession:

    Protein attributes for MAGEA10 Gene

    369 amino acids
    Molecular mass:
    40780 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEA10 Gene

Post-translational modifications for MAGEA10 Gene

No Post-translational modifications

Other Protein References for MAGEA10 Gene

No data available for DME Specific Peptides for MAGEA10 Gene

Domains & Families for MAGEA10 Gene

Gene Families for MAGEA10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MAGEA10 Gene


Suggested Antigen Peptide Sequences for MAGEA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAGEA10: view

No data available for UniProtKB/Swiss-Prot for MAGEA10 Gene

Function for MAGEA10 Gene

Molecular function for MAGEA10 Gene

GENATLAS Biochemistry:
human melanoma antigen,family A,member 10,expressed in placenta,melanoma and testis
UniProtKB/Swiss-Prot Function:
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Phenotypes for MAGEA10 Gene

genes like me logo Genes that share phenotypes with MAGEA10: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEA10 Gene

Localization for MAGEA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEA10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAGEA10 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAGEA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MAGEA10: view

Pathways & Interactions for MAGEA10 Gene

SuperPathways for MAGEA10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAGEA10 Gene


No data available for Pathways by source and SIGNOR curated interactions for MAGEA10 Gene

Drugs & Compounds for MAGEA10 Gene

No Compound Related Data Available

Transcripts for MAGEA10 Gene

Unigene Clusters for MAGEA10 Gene

Melanoma antigen family A, 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP2: -
SP3: - -

Relevant External Links for MAGEA10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAGEA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAGEA10 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEA10 Gene

This gene is overexpressed in Testis (x46.5).

Protein differential expression in normal tissues from HIPED for MAGEA10 Gene

This gene is overexpressed in Bone (35.4), Stomach (17.4), and Placenta (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAGEA10 Gene

Protein tissue co-expression partners for MAGEA10 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAGEA10 Gene:


SOURCE GeneReport for Unigene cluster for MAGEA10 Gene:


mRNA Expression by UniProt/SwissProt for MAGEA10 Gene:

Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for spermatogonia, spermatocytes and placenta.

Evidence on tissue expression from TISSUES for MAGEA10 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with MAGEA10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAGEA10 Gene

Orthologs for MAGEA10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEA10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAGEA10 33 34
  • 98.72 (n)
(Bos Taurus)
Mammalia LOC508073 33
  • 73.29 (n)
-- 34
  • 60 (a)
-- 34
  • 50 (a)
-- 34
  • 49 (a)
-- 34
  • 49 (a)
-- 34
  • 48 (a)
-- 34
  • 46 (a)
-- 34
  • 46 (a)
-- 34
  • 46 (a)
-- 34
  • 46 (a)
-- 34
  • 44 (a)
-- 34
  • 44 (a)
-- 34
  • 43 (a)
-- 34
  • 41 (a)
-- 34
  • 40 (a)
-- 34
  • 39 (a)
(Mus musculus)
Mammalia Magea10 16 33
  • 67.7 (n)
(Rattus norvegicus)
Mammalia Magea10 33
  • 66.88 (n)
(Canis familiaris)
Mammalia -- 34
  • 49 (a)
-- 34
  • 46 (a)
-- 34
  • 46 (a)
-- 34
  • 46 (a)
-- 34
  • 46 (a)
-- 34
  • 46 (a)
-- 34
  • 45 (a)
-- 34
  • 44 (a)
-- 34
  • 44 (a)
-- 34
  • 43 (a)
-- 34
  • 42 (a)
-- 34
  • 35 (a)
Species where no ortholog for MAGEA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA10 Gene

Gene Tree for MAGEA10 (if available)
Gene Tree for MAGEA10 (if available)

Paralogs for MAGEA10 Gene

genes like me logo Genes that share paralogs with MAGEA10: view

Variants for MAGEA10 Gene

Sequence variations from dbSNP and Humsavar for MAGEA10 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000042912 -- 152,133,846(-) C/A/T 3_prime_UTR_variant
rs1000429471 -- 152,139,213(-) C/T upstream_transcript_variant
rs1000679200 -- 152,136,920(-) G/A 5_prime_UTR_variant
rs1001364862 -- 152,137,428(-) G/T intron_variant
rs1001838664 -- 152,137,642(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MAGEA10 Gene

Variant ID Type Subtype PubMed ID
nsv520971 CNV gain 19592680

Variation tolerance for MAGEA10 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MAGEA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA10 Gene

Disorders for MAGEA10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAGEA10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • malignant melanoma
dyskeratosis congenita
  • zinsser-cole-engman syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MAGEA10

genes like me logo Genes that share disorders with MAGEA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA10 Gene

Publications for MAGEA10 Gene

  1. MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies. (PMID: 21710496) Schultz-Thater E … Spagnoli GC (International journal of cancer 2011) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants. (PMID: 15355897) Lin J … Beer DG (Clinical cancer research : an official journal of the American Association for Cancer Research 2004) 3 22 58
  4. cDNA and protein characterization of human MAGE-10. (PMID: 10446460) Rimoldi D … Cerottini JC (International journal of cancer 1999) 3 22 58
  5. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner UC … Poustka A (Genomics 1995) 2 3 58

Products for MAGEA10 Gene

Sources for MAGEA10 Gene

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