MAGEA10 Gene
protein-coding GIFtS: 50
GCID: GC0XM151302
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|
melanoma antigen family A, 10
(Previous symbol: MAGE10)
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Aliases
for MAGEA10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Melanoma Antigen Family A, 101 2 | | MAGE-10 Antigen2 3 | | MAGE101 2 3 5 | | MGC105991 | | CT1.101 2 3 | | Cancer/Testis Antigen Family 1, Member 102 | | Cancer/Testis Antigen 1.102 3 | | Melanoma-Associated Antigen 102 |
Export aliases for MAGEA10 gene to outside databasesPrevious GC identifers: GC0XM145637 GC0XM147960 GC0XM149050 GC0XM149920 GC0XM150973 GC0XM151052 GC0XM140156 |
Summaries
for MAGEA10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAGEA10:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequenceidentity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggestingthat the existence of this gene family enables the same function to be expressed under different transcriptionalcontrols. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditarydisorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-throughtranscription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.(provided byRefSeq, Oct 2011)
UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumorprogression
|
Genomic Views
for MAGEA10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAGEA10 gene promoter:
NCX/Ncx MEF-2A POU2F1 GATA-6 Nkx6-1 FOXJ2 (long isoform) POU2F1a aMEF-2 FOXJ2 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAGEA10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAGEA10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28MAGEA10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM151302: view genomic region
(about GC identifiers)
Start:
|
151,301,782 bp from pter |
End:
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151,307,033 bp from pter |
Size:
|
5,252 bases |
Orientation:
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minus strand |
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Proteins
for MAGEA10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363 (See
protein sequence)Recommended Name: Melanoma-associated antigen 10 Size: 369 amino acids; 40780 Da
Subcellular location: NucleusExplore the universe of human proteins at neXtProt for MAGEA10: NX_P43363
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P43363
MAGEA10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001011543.2 NP_001238757.1 NP_066386.2
ENSEMBL proteins: ENSP00000359347 ENSP00000406161 ENSP00000391977 ENSP00000464160 ENSP00000462833 ENSP00000244096
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
MAGEA10 for ontologies About GeneDecksing
MAGEA10 Antibody Products:
Assay Products for MAGEA10: |
Protein
Domains /
Families
for MAGEA10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAGEA10 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P43363ProtoNet protein and cluster: P43363 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363Similarity: Contains 1 MAGE domain |
Function
for MAGEA10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumorprogression Genatlas biochemistry entry for MAGEA10:human melanoma antigen,family A,member 10,expressed in placenta,melanoma and testis
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAGEA10 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA10 |
|
Pathways & Interactions
for MAGEA10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEA10
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for MAGEA10 (ENSP000002440964) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for MAGEA10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAGEA10
Search CenterWatch for drugs/clinical trials and news about MAGEA10 / MAGAA
|
Transcripts
for MAGEA10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAGEA10 gene (3 alternative transcripts): NM_001011543.2 NM_001251828.1 NM_021048.4 Unigene Cluster for MAGEA10: Melanoma antigen family A, 10 Hs.18048 [show with all ESTs]Unigene Representative Sequence: NM_0010115436 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370323(uc004ffk.3 uc004ffm.2 uc004ffl.3) ENST00000444834
ENST00000427322 ENST00000583480 ENST00000579960 ENST00000244096
Clone
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Synthesis Service for MAGEA10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAGEA10 |
Additional cDNA sequence: AK314161.1 AY522506.1 AY531264.1 BC004105.2 6 DOTS entries: DT.86849784 DT.91676023 DT.97836077 DT.100746182 DT.423199 DT.423198 24/48 AceView cDNA sequences (see all 48): BX335540 AY531264 BG477105 BQ217649 BE277360 CR622868 AI142010 BG477436 BX109673 CB158974 BG477980 BG478456 NM_021048 BE730450 BC004105 CD109866 BE277068 BG478664 AY310324 BU167137 R23725 AI200443 BX097006 BE389926
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA10 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAGEA10
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Expression
for MAGEA10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAGEA10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTTACTCA
About this image
See MAGEA10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAGEA10
SOURCE GeneReport for Unigene cluster: Hs.18048
UniProtKB/Swiss-Prot: MAGAA_HUMAN, P43363Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma,lung carcinoma and breast carcinoma, but not in normal tissues except for spermatogonia, spermatocytes and placenta
SABiosciences Custom PCR Arrays for MAGEA10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAGEA10
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA10 |
Orthologs
for MAGEA10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MAGEA10 gene from 3/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
35(a) |
1 → many |
1(205669616-205678308) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndnl26 |
necdin-like 2 |
29(a) |
1 → many |
23(13012414-13025121) |
fruit fly
(Drosophila melanogaster) |
Insecta |
MAGE6 |
MAGE |
22(a) |
1 → many |
3R(2979960-2980898) |
ENSEMBL Gene Tree for MAGEA10 (if available)
TreeFam Gene Tree for MAGEA10 (if available) |
Paralogs
for MAGEA10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAGEA10 gene
- MAGEC22 MAGEA9B2 MAGEB52 MAGEB162 MAGEB42 MAGEB12 MAGEC12 MAGED42
- MAGEA82 MAGED22 MAGEA122 MAGEA92 MAGEB172 MAGEB102 MAGEA62 MAGEE12
- MAGED12 MAGEA22 MAGEC32 MAGEA32 NDN2 MAGEB22 MAGEB32 MAGED4B2
- MAGEE22 MAGEA42 MAGEA12 MAGEB182 MAGEA2B2 MAGEB62 MAGEL22 TRO2
- MAGEA112 NDNL22 MAGEF12
18/35 SIMAP similar genes for MAGEA10 using alignment to 5 protein entries: MAGAA_HUMAN (see all proteins)
(see all similar genes):MAGEC4 MAGEC1 MAGEC3 MAGEA9B MAGEH1 MAGEB16
MAGEA13P NDNL2 TRO MAGEA8 MAGEB1 MAGEB4
MAGE-B1 MAGEA12 MAGEB18 MAGEB2 MAGEB5 MAGEC2
MAGEA10 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for MAGEA10
PGOHUM00000241578 PGOHUM00000241595 PGOHUM00000241689 PGOHUM00000241756 PGOHUM00000242044
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Genomic Variants
for MAGEA10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAGEA10 (151301782 - 151307033 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAGEA10
1 CNV: 52961 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAGEA10 |
|
Disorders
/ Diseases
for MAGEA10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAGEA10 for disorders About GeneDecksing
OMIM gene information: 300343
OMIM disorders: --
15  diseases for MAGEA10: About MalaCardsdyskeratosis congenita melanoma dyskeratosis intrahepatic cholangiocarcinoma
squamous cell carcinoma stomach cancer multiple myeloma cholangiocarcinoma
myeloma lung carcinoma breast carcinoma carcinoma
breast cancer esophagitis adenocarcinoma
2 Novoseek disease relationships for MAGEA10 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| melanoma |
43 |
3 |
10446460 (2), 10521804 (1) |
| tumors |
14.2 |
2 |
10446460 (1), 10521804 (1) |
Export disorders for MAGEA10 gene to outside databases
|
Publications
for MAGEA10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAGEA10 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with MAGEA10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies. (PubMed id 21710496)1, 2 Schultz-Thater E....Spagnoli G.C. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PubMed id 8575766)1, 3 Rogner U.C....Poustka A. (1995)
- Structure, chromosomal localization, and expression of 12 genes of the MAGE family. (PubMed id 7927540)1, 2 De Plaen E.... Boon T. (1994)
- Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants. (PubMed id 15355897)1, 9 Lin J....Beer D.G. (2004)
- cDNA and protein characterization of human MAGE-10. (PubMed id 10446460)1, 9 Rimoldi D....Cerottini J.C. (1999)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Prognostic impact of cancer/testis antigen expression in advanced stage multiple myeloma patients. (PubMed id 18237105)1 Andrade V.C....Colleoni G.W. (2008)
- The use of filamentous bacteriophage fd to deliver MA GE-A10 or MAGE-A3 HLA-A2-restricted peptides and to induce strong antitumor CTL responses. (PubMed id 18322177)1 Sartorius R....De Berardinis P. (2008)
- Tissue homing and persistence of defined antigen-spec ific CD8+ tumor-reactive T-cell clones in long-term melanoma survivors. (PubMed id 17039243)1 Le Gal F.A....Dietrich P.Y. (2007)
|
External Searches for MAGEA10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAGEA10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAGEA10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEA10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAGEA10 gene:
Search GeneIP for patents involving MAGEA10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAGEA10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAGEA10 |
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