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Aliases for MAGEA10 Gene

Aliases for MAGEA10 Gene

  • MAGE Family Member A10 2 3 5
  • MAGE-10 Antigen 2 3 4
  • Melanoma Antigen Family A10 2 3
  • Cancer/Testis Antigen 1.10 3 4
  • MAGE10 3 4
  • CT1.10 3 4
  • Cancer/Testis Antigen Family 1, Member 10 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma-Associated Antigen 10 2
  • Melanoma Antigen Family A, 10 3
  • Member 10 2

External Ids for MAGEA10 Gene

Previous HGNC Symbols for MAGEA10 Gene

  • MAGE10

Previous GeneCards Identifiers for MAGEA10 Gene

  • GC0XM145637
  • GC0XM147960
  • GC0XM149050
  • GC0XM149920
  • GC0XM150973
  • GC0XM151052
  • GC0XM151302
  • GC0XM140156

Summaries for MAGEA10 Gene

Entrez Gene Summary for MAGEA10 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011]

GeneCards Summary for MAGEA10 Gene

MAGEA10 (MAGE Family Member A10) is a Protein Coding gene. Diseases associated with MAGEA10 include melanoma and dyskeratosis congenita. An important paralog of this gene is MAGEC3.

UniProtKB/Swiss-Prot for MAGEA10 Gene

  • Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA10 Gene

Genomics for MAGEA10 Gene

Regulatory Elements for MAGEA10 Gene


Genomic Location for MAGEA10 Gene

Chromosome:
X
Start:
152,133,310 bp from pter
End:
152,138,578 bp from pter
Size:
5,269 bases
Orientation:
Minus strand

Genomic View for MAGEA10 Gene

Genes around MAGEA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA10 Gene

Proteins for MAGEA10 Gene

  • Protein details for MAGEA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43363-MAGAA_HUMAN
    Recommended name:
    Melanoma-associated antigen 10
    Protein Accession:
    P43363

    Protein attributes for MAGEA10 Gene

    Size:
    369 amino acids
    Molecular mass:
    40780 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MAGEA10 Gene

Proteomics data for MAGEA10 Gene at MOPED

Post-translational modifications for MAGEA10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAGEA10 Gene

No data available for DME Specific Peptides for MAGEA10 Gene

Domains & Families for MAGEA10 Gene

Gene Families for MAGEA10 Gene

Protein Domains for MAGEA10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43363

UniProtKB/Swiss-Prot:

MAGAA_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEA10: view

Function for MAGEA10 Gene

Molecular function for MAGEA10 Gene

GENATLAS Biochemistry:
human melanoma antigen,family A,member 10,expressed in placenta,melanoma and testis
UniProtKB/Swiss-Prot Function:
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.

Phenotypes for MAGEA10 Gene

genes like me logo Genes that share phenotypes with MAGEA10: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEA10 Gene

Localization for MAGEA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEA10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEA10 Gene COMPARTMENTS Subcellular localization image for MAGEA10 gene
Compartment Confidence
nucleus 4
cytosol 2
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for MAGEA10 Gene

Pathways & Interactions for MAGEA10 Gene

SuperPathways for MAGEA10 Gene

No Data Available

Interacting Proteins for MAGEA10 Gene

Gene Ontology (GO) - Biological Process for MAGEA10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MAGEA10 Gene

Drugs & Compounds for MAGEA10 Gene

No Compound Related Data Available

Transcripts for MAGEA10 Gene

Unigene Clusters for MAGEA10 Gene

Melanoma antigen family A, 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2: -
SP3: - -
SP4:

Relevant External Links for MAGEA10 Gene

GeneLoc Exon Structure for
MAGEA10
ECgene alternative splicing isoforms for
MAGEA10

Expression for MAGEA10 Gene

mRNA expression in normal human tissues for MAGEA10 Gene

mRNA differential expression in normal tissues according to GTEx for MAGEA10 Gene

This gene is overexpressed in Testis (x46.5).

Protein differential expression in normal tissues from HIPED for MAGEA10 Gene

This gene is overexpressed in Bone (35.4), Stomach (17.4), and Placenta (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEA10 Gene



SOURCE GeneReport for Unigene cluster for MAGEA10 Gene Hs.18048

mRNA Expression by UniProt/SwissProt for MAGEA10 Gene

P43363-MAGAA_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for spermatogonia, spermatocytes and placenta.
genes like me logo Genes that share expression patterns with MAGEA10: view

Protein tissue co-expression partners for MAGEA10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAGEA10 Gene

Orthologs for MAGEA10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MAGEA10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC508073 35
  • 73.29 (n)
  • 59.64 (a)
-- 36
  • 46 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Magea10 35
  • 67.7 (n)
  • 55.28 (a)
Magea10 16
chimpanzee
(Pan troglodytes)
Mammalia MAGEA10 35
  • 98.72 (n)
  • 98.08 (a)
MAGEA10 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Magea10 35
  • 66.88 (n)
  • 56.92 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 49 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
Species with no ortholog for MAGEA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA10 Gene

ENSEMBL:
Gene Tree for MAGEA10 (if available)
TreeFam:
Gene Tree for MAGEA10 (if available)

Paralogs for MAGEA10 Gene

genes like me logo Genes that share paralogs with MAGEA10: view

Variants for MAGEA10 Gene

Sequence variations from dbSNP and Humsavar for MAGEA10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_024528 -
VAR_053496 -

Structural Variations from Database of Genomic Variants (DGV) for MAGEA10 Gene

Variant ID Type Subtype PubMed ID
nsv520971 CNV Gain 19592680

Variation tolerance for MAGEA10 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAGEA10 Gene

HapMap Linkage Disequilibrium report
MAGEA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAGEA10 Gene

Disorders for MAGEA10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MAGEA10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
dyskeratosis congenita
  • revesz syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEA10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEA10
genes like me logo Genes that share disorders with MAGEA10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA10 Gene

Publications for MAGEA10 Gene

  1. MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies. (PMID: 21710496) Schultz-Thater E. … Spagnoli G.C. (Int. J. Cancer 2011) 3 4 67
  2. Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants. (PMID: 15355897) Lin J. … Beer D.G. (Clin. Cancer Res. 2004) 3 23
  3. cDNA and protein characterization of human MAGE-10. (PMID: 10446460) Rimoldi D. … Cerottini J.C. (Int. J. Cancer 1999) 3 23
  4. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. (PMID: 8575766) Rogner U.C. … Poustka A. (Genomics 1995) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MAGEA10 Gene

Sources for MAGEA10 Gene

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