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MAGEA1 Gene

protein-coding   GIFtS: 57

GC0XM152134
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MAGE1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CT1.1 1, 2, 3
MAGE1 2, 3
MAGE1A 3
MGC9326 1, 2
OTTHUMP00000025911 2
Descriptions
Antigen MZ2-E 3
Cancer/testis antigen 1.1 3
MAGE-1 antigen 3
cancer/testis antigen family 1, member 1 2
melanoma antigen MAGE-1 2
melanoma antigen family A 1 2
melanoma antigen family A, 1 2
melanoma antigen family A, 1 (directs expression of antigen
MZ2-E) 2
melanoma-associated antigen 1 2
melanoma-associated antigen MZ2-E 2
External Ids
HGNC: 67961
Entrez Gene: 41002
UniProtKB: P433553
Ensembl: ENSG000001986817
Search outside databases for aliases for MAGEA1 gene

Previous GC identifers: GC0XM146635 GC0XM148952 GC0XM150043 GC0XM150912 GC0XM151965

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAGEA1:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50
to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show
considerable variability, suggesting that the existence of this gene family enables the same
function to be expressed under different transcriptional controls. The MAGEA genes are clustered
at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as
dyskeratosis congenita. [provided by RefSeq]

UniProtKB/Swiss-Prot: MAGA1_HUMAN, P43355
Function: Not known, though may play a role in embryonal development and tumor transformation or
aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic
T-lymphocytes

Gene Wiki entry for MAGEA1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the MAGEA1 gene  

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

MAGEA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM152134:     (about GC identifiers)

Start:
152,134,716 bp from pter
End:
152,139,310 bp from pter
Size:
4,595 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011726.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: MAGA1_HUMAN, P43355 (See protein sequence)
Recommended Name: Melanoma-associated antigen 1  
Size: 309 amino acids; 34342 Da
Subcellular location: Cytoplasm
PDB structure from and Proteopedia :
1W72 (3D)    3BO8 (3D)    
Secondary accessions: O00346

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004979.3  

    ENSEMBL proteins: 
    ENSP00000349085 


    Human Recombinant Proteins 
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (MAGE 1)
    Human Recombinant Proteins from Abnova (MAGEA1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005886 plasma membrane TAS1840703
    About this table

    Antibodies for MAGEA1: 
    Invitrogen Antibodies for MAGEA1
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    Antibodies from Abcam (MAGE 1), each with their AbpromiseSM
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    Novus Biologicals Antibodies for MAGEA1

    Assays for MAGEA1: 
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    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR002190 MAGE


       GeneDecks  MAGEA1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P43355

    ProtoNet protein and cluster: P43355

    1 Blocks protein family: IPB002190 MAGE protein

    UniProtKB/Swiss-Prot: MAGA1_HUMAN, P43355
    Similarity: Contains 1 MAGE domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MAGEA1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MAGEA1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004988

                  Applied Biosystems Silencer® siRNAs for MAGEA1

                  Sigma-Aldrich siRNA for MAGEA1  
                         Sigma-Aldrich shRNA for MAGEA1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004988
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004988
                                     untagged cDNA clone in CMV expression vector: NM_004988 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004988

    UniProtKB/Swiss-Prot: MAGA1_HUMAN, P43355
    Function: Not known, though may play a role in embryonal development and tumor transformation or
    aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic
    T-lymphocytes

    Genatlas biochemistry entry for MAGEA1:
    melanoma antigen,family A,member 1,directing expression of antigen MZ2-E,expressed in
    melanoma,testis,advanced gastric carcinomas and hepatocellular carcinomas
    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  MAGEA1 


    5/7 Interacting proteins for MAGEA1 (P433552 ENSP000003490853) via UniProtKB, MINT, and/or STRING (see all 7 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GLB2Q9NR462MINT-67557
    UQCRBP149272MINT-67618
    BAGE5ENSP000003355283STRING (score=.956)
    ZNF594ENSP000003711713STRING (score=.857)
    ENSG00000206503ENSP000003659993STRING (score=.775)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for MAGEA1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (MAGEA1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (MAGEA1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004988

                  Sigma-Aldrich siRNA for MAGEA1  
                         Sigma-Aldrich shRNA for MAGEA1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004988  

    REFSEQ mRNAs for MAGEA1 gene: 

    NM_004988.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004988  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004988
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004988
                                     untagged cDNA clone in CMV expression vector: NM_004988 

    Additional cDNA sequence: 

    AF463515.1 AK314979.1 AY148486.1 BC017555.1 BT009789.1 EU161102.1 

    1 DOTS entry:

    DT.303176 

    19 AceView cDNA sequences:

    AW103876 BM989182 CA428506 CA423766 AF463515 NM_004988 BV196059 BQ224380 
    BU175213 BU153093 BX282460 BC017555 BM459064 BU157186 BT009789 BV196058 
    AY148486 BG030623 BU564836 

    highest scoring ESTs for MAGEA1:

    AY148486 BC017555 BG030623 BU153093 BU175213 AF463515 AW103876 BE895498 BM907822 BM989182 

    Unigene Cluster for MAGEA1:

    Melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
    Hs.72879  [show with all ESTs]
    Unigene Representative Sequence: NM_004988


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000356661  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    MAGEA1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for MAGEA1

    1 / 2 / 3

    3 probe-sets matching MAGEA1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    32426_f_at2, 3 U95-A 9 1.00 0.45 1.00 1.00 U82672 0.20 1.00 0.72 1

    207325_x_at2, 3 U133-A 8 1.00 0.68 -- -- NM_004988 0.60 1.00 0.82 1

    207325_x_at2 U133Plus2 8 1.00 0.68 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGGCCCATTC

    SOURCE GeneReport for Unigene cluster: Hs.72879

    Expression variation in blood from EXPOLDB for MAGEA1

    UniProtKB/Swiss-Prot: MAGA1_HUMAN, P43355
    Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck
    squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for
    testes. Never expressed in kidney tumors, leukemias and lymphomas

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for MAGEA1 gene from 1 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    MAGEA11   -- melanoma antigen family A, 1 (directs expression of more 98.92(n)
    98.19(a)
    473852  XM_529226.2  XP_529226.2 
    About this table        Species with no ortholog for MAGEA1

    ENSEMBL Gene Tree for MAGEA1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for MAGEA1 gene
    MAGEA32  MAGEA2B2  MAGEA82  MAGEA122  MAGEA92  MAGEA9B2  MAGEA42  MAGEA112  
    MAGEA102  MAGEA62  MAGEA22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/38 NCBI SNPs in MAGEA1 are shown (see all 38 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 49)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs20081441,2
    A,C,F,H152135990(-) CACTCG/AACAGA 1 Q/R mis1 ese317Minor allele frequency- A:0.21EU EA WA NS 1036
    rs20081601,2
    A,C,F,H152136111(-) CTGCCA/GCCTCC 1 T/A mis1 ese34Minor allele frequency- G:0.42EU EA WA 416
    rs22330441,2
    C,F,H152136018(-) CCTCCG/ACCTTT 1 T/A mis1 ese34Minor allele frequency- A:0.01EU EA WA 402
    --
    rs48287541,2
    A,F,H152140992(+) TTTCTA/GGGAAA 1 -- ng31 tfbs34Minor allele frequency- G:0.27EU EA WA 418
    --
    rs59248071,2
    A,C152140737(+) aacatA/Ggtgaa 1 -- ng310--------
    --
    rs7171051,2
    A,H152136224(-) GCCTGC/TTGCCC 1 -- ut51 ese34Minor allele frequency- T:0.00EU EA WA 412
    rs59248061,2
    C152140395(+) CTCCCA/GGCTCC 1 -- ng310--------
    rs125562591,2
    C152139777(+) GGGGTC/TCTCTA 1 -- ng310--------
    rs21876451,2
    F,H152135701(+) ACATAG/AGAGTG 1 S/S syn1 ese34Minor allele frequency- A:0.01EU EA WA 388
    rs37887531,2
    A,C,F,H152139070(+) AGAACC/GTGGTG 1 -- int14Minor allele frequency- G:0.26EU EA WA 416
    About this table

    HapMap Linkage Disequilibrium images for MAGEA1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 300016

    10/49 Novoseek disease relationships for MAGEA1 gene (see all 49 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 80.77 108 7511051 (5), 7814879 (4), 8707418 (3), 17957795 (3) (see all 61)
    testicular cancer 77.18 5 11668506 (1), 11953832 (1), 16467087 (1), 17208940 (1) (see all 5)
    tumors 64.44 205 8900375 (5), 18820946 (5), 18505125 (4), 15143172 (4) (see all 94)
    hepatocellular carcinoma 60.31 43 19260505 (4), 10961717 (3), 16082588 (2), 10592101 (2) (see all 24)
    cancer 54.54 36 17007017 (3), 9131385 (2), 15703841 (2), 12877803 (2) (see all 25)
    hepatic hemangioma 50.80 1 15498320 (1)
    pediatric solid tumor 47.98 1 8900370 (1)
    gastric carcinoma 45.32 11 11289403 (3), 9121149 (3), 9854470 (3), 7557134 (2)
    ocular melanoma 41.05 2 9220316 (2)
    leukemia b-cell 39.36 1 7656275 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/223 PubMed articles for MAGEA1 gene (see all 223 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 4100 HGNC: 6796 AceView: MAGEA1 Ensembl:ENSG00000198681 euGenes: HUgn4100
    ECgene: MAGEA1 H-InvDB: MAGEA1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for MAGEA1 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for MAGEA1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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