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Aliases & Descriptions for MAGEA1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CT1.1 1, 2, 3 | | MAGE1 2, 3 | | MAGE1A 3 | | MGC9326 1, 2 | | OTTHUMP00000025911 2 |
| | | Descriptions |
|---|
| Antigen MZ2-E 3 | | Cancer/testis antigen 1.1 3 | | MAGE-1 antigen 3 | | cancer/testis antigen family 1, member 1 2 | | melanoma antigen MAGE-1 2 | | melanoma antigen family A 1 2 | | melanoma antigen family A, 1 2 | melanoma antigen family A, 1 (directs expression of antigen MZ2-E) 2 | | melanoma-associated antigen 1 2 | | melanoma-associated antigen MZ2-E 2 |
|
| | Search outside databases for aliases for MAGEA1 genePrevious GC identifers: GC0XM146635 GC0XM148952 GC0XM150043 GC0XM150912 GC0XM151965 |
Summaries for MAGEA1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for MAGEA1: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq] UniProtKB/Swiss-Prot: MAGA1_HUMAN, P43355Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytesGene Wiki entry for MAGEA1 |
Genomic Location for MAGEA1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the MAGEA1 gene 
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28MAGEA1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM152134:
(about GC identifiers)
Start:
|
152,134,716 bp from pter |
End:
|
152,139,310 bp from pter |
Size:
|
4,595 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011726.13
| Proteins for MAGEA1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: MAGA1_HUMAN, P43355 (See
protein sequence)Recommended Name: Melanoma-associated antigen 1 Size: 309 amino acids; 34342 Da
Subcellular location: Cytoplasm
PDB structure from and Proteopedia :1W72 (3D)
 3BO8 (3D)
 
Secondary accessions: O00346Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004979.3
ENSEMBL proteins: ENSP00000349085
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for MAGEA1: Assays for MAGEA1: | Protein
Domains/ Families for MAGEA1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P43355
ProtoNet protein and cluster: P43355 1 Blocks protein family: IPB002190 MAGE protein
UniProtKB/Swiss-Prot: MAGA1_HUMAN, P43355Similarity: Contains 1 MAGE domain | Gene Function for MAGEA1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004988
Applied Biosystems Silencer® siRNAs for MAGEA1
Sigma-Aldrich siRNA for MAGEA1  Sigma-Aldrich shRNA for MAGEA1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004988                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004988                                  untagged cDNA clone in CMV expression vector: NM_004988 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004988
UniProtKB/Swiss-Prot: MAGA1_HUMAN, P43355Function: Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytesGenatlas biochemistry entry for MAGEA1:melanoma antigen,family A,member 1,directing expression of antigen MZ2-E,expressed in melanoma,testis,advanced gastric carcinomas and hepatocellular carcinomas | Pathways & Interactions for MAGEA1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for MAGEA1 
5/7 Interacting proteins for MAGEA1 (P433552 ENSP000003490853) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
|
Drugs & Compounds for MAGEA1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for MAGEA1
|
Transcripts for MAGEA1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004988
Sigma-Aldrich siRNA for MAGEA1  Sigma-Aldrich shRNA for MAGEA1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004988 REFSEQ mRNAs for MAGEA1 gene: NM_004988.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004988               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004988                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004988                                  untagged cDNA clone in CMV expression vector: NM_004988  Additional cDNA sequence: AF463515.1 AK314979.1 AY148486.1 BC017555.1 BT009789.1 EU161102.1 1 DOTS entry: DT.303176 19 AceView cDNA sequences:AW103876 BM989182 CA428506 CA423766 AF463515 NM_004988 BV196059 BQ224380 BU175213 BU153093 BX282460 BC017555 BM459064 BU157186 BT009789 BV196058 AY148486 BG030623 BU564836
highest scoring ESTs for MAGEA1:AY148486 BC017555 BG030623 BU153093 BU175213 AF463515 AW103876 BE895498 BM907822 BM989182 Unigene Cluster for MAGEA1: Melanoma antigen family A, 1 (directs expression of antigen MZ2-E) Hs.72879 [show with all ESTs]Unigene Representative Sequence: NM_004988
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000356661
|
Expression for MAGEA1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| MAGEA1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for MAGEA1
1 / 2 / 3 3 probe-sets matching MAGEA1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGGCCCATTC
SOURCE GeneReport for Unigene cluster: Hs.72879
Expression variation in blood from EXPOLDB for MAGEA1 UniProtKB/Swiss-Prot: MAGA1_HUMAN, P43355Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas |
Orthologs for MAGEA1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MAGEA1 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
chimpanzee (Pan troglodytes) |
MAGEA11 |
-- |
melanoma antigen family A, 1 (directs expression of more |
98.92(n) 98.19(a) |
473852 XM_529226.2 XP_529226.2 |
About this table Species with no ortholog for MAGEA1
ENSEMBL Gene Tree for MAGEA1 | Paralogs for MAGEA1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for MAGEA1 gene
- MAGEA32 MAGEA2B2 MAGEA82 MAGEA122 MAGEA92 MAGEA9B2 MAGEA42 MAGEA112
- MAGEA102 MAGEA62 MAGEA22
|
SNPs/Variants for MAGEA1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for MAGEA1 (up to first 250kb)
|
Disorders & Mutations for MAGEA1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300016
10/49 Novoseek disease relationships for MAGEA1 gene (see all 49
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| melanoma |
80.77 |
108 |
7511051 (5), 7814879 (4), 8707418 (3), 17957795 (3) (see all 61) |
| testicular cancer |
77.18 |
5 |
11668506 (1), 11953832 (1), 16467087 (1), 17208940 (1) (see all 5) |
| tumors |
64.44 |
205 |
8900375 (5), 18820946 (5), 18505125 (4), 15143172 (4) (see all 94) |
| hepatocellular carcinoma |
60.31 |
43 |
19260505 (4), 10961717 (3), 16082588 (2), 10592101 (2) (see all 24) |
| cancer |
54.54 |
36 |
17007017 (3), 9131385 (2), 15703841 (2), 12877803 (2) (see all 25) |
| hepatic hemangioma |
50.80 |
1 |
15498320 (1) |
| pediatric solid tumor |
47.98 |
1 |
8900370 (1) |
| gastric carcinoma |
45.32 |
11 |
11289403 (3), 9121149 (3), 9854470 (3), 7557134 (2) |
| ocular melanoma |
41.05 |
2 |
9220316 (2) |
| leukemia b-cell |
39.36 |
1 |
7656275 (1) |
About this table
|
Medical News for MAGEA1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for MAGEA1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/223 PubMed articles for MAGEA1 gene (see all 223
):- A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. (PubMed id 1840703)1, 2, 3, 4 van der Bruggen P.... Boon T. (1991)
- MAGE-1 gene product is a cytoplasmic protein. (PubMed id 7927954)1, 3, 4 Schultz-Thater E.... Spagnoli G.C. (1994)
- Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. (PubMed id 8113684)1, 3, 4 Gaugler B.... Boon T. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. (PubMed id 10854409)3, 4 Mallon A.M....Brown S.D. (2000)
- Cloning and analysis of MAGE-1-related genes. (PubMed id 8037761)3, 4 Ding M.... Fenton R.G. (1994)
- MAGE-A1 expression is associated with good prognosis in neuroblastoma tumors. (PubMed id 18820946)1, 3 Grau E....Castel V. (2009)
- [The genetic polymorphism of melanoma-associated antigen 1 in Chinese normal donors and hepatoma patients] (PubMed id 15059299)1, 3 Wang L.P....Wei L. (2004)
- Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells. (PubMed id 16497664)1, 3 Loriot A....De Smet C. (2006)
- Identification of the MAGE-1 gene product by monoclonal and polyclonal antibodies. (PubMed id 8302824)1, 3 Chen Y.T....Old L.J. (1994)
|
Search for MAGEA1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MAGEA1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing MAGEA1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAGEA1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for MAGEA1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
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