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Aliases for MAGEA1 Gene

Aliases for MAGEA1 Gene

  • MAGE Family Member A1 2 3 5
  • Melanoma Antigen Family A, 1 (Directs Expression Of Antigen MZ2-E) 2 3
  • Melanoma-Associated Antigen MZ2-E 2 3
  • Melanoma Antigen Family A 1 2 3
  • Melanoma Antigen Family A1 2 3
  • Cancer/Testis Antigen 1.1 3 4
  • Melanoma Antigen MAGE-1 2 3
  • MAGE-1 Antigen 3 4
  • Antigen MZ2-E 3 4
  • MAGE1 3 4
  • CT1.1 3 4
  • Cancer/Testis Antigen Family 1, Member 1 3
  • Cancer/Testis Antigen Family 1 2
  • Melanoma-Associated Antigen 1 2
  • Member 1 2
  • MAGE1A 4

External Ids for MAGEA1 Gene

Previous HGNC Symbols for MAGEA1 Gene

  • MAGE1

Previous GeneCards Identifiers for MAGEA1 Gene

  • GC0XM146635
  • GC0XM148952
  • GC0XM150043
  • GC0XM150912
  • GC0XM151965
  • GC0XM152134
  • GC0XM152481
  • GC0XM141141

Summaries for MAGEA1 Gene

Entrez Gene Summary for MAGEA1 Gene

  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAGEA1 Gene

MAGEA1 (MAGE Family Member A1) is a Protein Coding gene. Diseases associated with MAGEA1 include Melanoma and Hemangioma Of Liver. Among its related pathways are Notch signaling pathway (KEGG). GO annotations related to this gene include histone deacetylase binding. An important paralog of this gene is MAGEC3.

UniProtKB/Swiss-Prot for MAGEA1 Gene

  • May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Gene Wiki entry for MAGEA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAGEA1 Gene

Genomics for MAGEA1 Gene

Regulatory Elements for MAGEA1 Gene

Enhancers for MAGEA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAGEA1 on UCSC Golden Path with GeneCards custom track

Promoters for MAGEA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAGEA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAGEA1 Gene

Chromosome:
X
Start:
153,179,284 bp from pter
End:
153,183,880 bp from pter
Size:
4,597 bases
Orientation:
Plus strand

Genomic View for MAGEA1 Gene

Genes around MAGEA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAGEA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAGEA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAGEA1 Gene

Proteins for MAGEA1 Gene

  • Protein details for MAGEA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43355-MAGA1_HUMAN
    Recommended name:
    Melanoma-associated antigen 1
    Protein Accession:
    P43355
    Secondary Accessions:
    • B2RC81
    • O00346

    Protein attributes for MAGEA1 Gene

    Size:
    309 amino acids
    Molecular mass:
    34342 Da
    Quaternary structure:
    • Interacts with SNW1 and HDCA1.

    Three dimensional structures from OCA and Proteopedia for MAGEA1 Gene

neXtProt entry for MAGEA1 Gene

Proteomics data for MAGEA1 Gene at MOPED

Post-translational modifications for MAGEA1 Gene

  • Ubiquitination at Lys 105, Lys 237, and Lys 278
  • Modification sites at PhosphoSitePlus

Other Protein References for MAGEA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAGEA1 Gene

Domains & Families for MAGEA1 Gene

Gene Families for MAGEA1 Gene

Protein Domains for MAGEA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAGEA1 Gene

Graphical View of Domain Structure for InterPro Entry

P43355

UniProtKB/Swiss-Prot:

MAGA1_HUMAN :
  • Contains 1 MAGE domain.
Domain:
  • Contains 1 MAGE domain.
genes like me logo Genes that share domains with MAGEA1: view

Function for MAGEA1 Gene

Molecular function for MAGEA1 Gene

GENATLAS Biochemistry:
melanoma antigen,family A,member 1,directing expression of antigen MZ2-E,expressed in melanoma,testis,advanced gastric carcinomas and hepatocellular carcinomas
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Phenotypes for MAGEA1 Gene

GenomeRNAi human phenotypes for MAGEA1:
genes like me logo Genes that share phenotypes with MAGEA1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAGEA1 Gene

Localization for MAGEA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAGEA1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAGEA1 Gene COMPARTMENTS Subcellular localization image for MAGEA1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MAGEA1 Gene

Pathways & Interactions for MAGEA1 Gene

SuperPathways for MAGEA1 Gene

genes like me logo Genes that share pathways with MAGEA1: view

Pathways by source for MAGEA1 Gene

1 BioSystems pathway for MAGEA1 Gene

Gene Ontology (GO) - Biological Process for MAGEA1 Gene

None

No data available for SIGNOR curated interactions for MAGEA1 Gene

Drugs & Compounds for MAGEA1 Gene

(4) Additional Compounds for MAGEA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MAGEA1: view

Transcripts for MAGEA1 Gene

mRNA/cDNA for MAGEA1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAGEA1 Gene

Melanoma antigen family A, 1 (directs expression of antigen MZ2-E):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAGEA1 Gene

No ASD Table

Relevant External Links for MAGEA1 Gene

GeneLoc Exon Structure for
MAGEA1
ECgene alternative splicing isoforms for
MAGEA1

Expression for MAGEA1 Gene

mRNA expression in normal human tissues for MAGEA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAGEA1 Gene

This gene is overexpressed in Testis (x49.7).

Protein differential expression in normal tissues from HIPED for MAGEA1 Gene

This gene is overexpressed in Neutrophil (23.5), Lung (22.6), and Bone (19.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAGEA1 Gene



SOURCE GeneReport for Unigene cluster for MAGEA1 Gene Hs.72879

mRNA Expression by UniProt/SwissProt for MAGEA1 Gene

P43355-MAGA1_HUMAN
Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.
genes like me logo Genes that share expression patterns with MAGEA1: view

Primer Products

No data available for Protein tissue co-expression partners for MAGEA1 Gene

Orthologs for MAGEA1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAGEA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAGEA1 35
  • 98.92 (n)
  • 98.19 (a)
MAGEA1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700080O16Rik 36
  • 39 (a)
ManyToMany
3830417A13Rik 36
  • 35 (a)
ManyToMany
Magea1 36
  • 38 (a)
ManyToMany
Magea10 36
  • 41 (a)
ManyToMany
Magea2 36
  • 38 (a)
ManyToMany
Magea3 36
  • 38 (a)
ManyToMany
Magea4 36
  • 38 (a)
ManyToMany
Magea5 36
  • 40 (a)
ManyToMany
Magea6 36
  • 39 (a)
ManyToMany
Magea8 36
  • 39 (a)
ManyToMany
Species with no ortholog for MAGEA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAGEA1 Gene

ENSEMBL:
Gene Tree for MAGEA1 (if available)
TreeFam:
Gene Tree for MAGEA1 (if available)

Paralogs for MAGEA1 Gene

genes like me logo Genes that share paralogs with MAGEA1: view

Variants for MAGEA1 Gene

Sequence variations from dbSNP and Humsavar for MAGEA1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2008160 - 153,182,483(-) CTGCC(A/G)CCTCC reference, missense
rs2008144 - 153,182,604(-) CACTC(A/G)ACAGA reference, missense
VAR_036581 A breast cancer sample
rs2233044 - 153,182,576(-) CCTCC(A/G)CCTTT reference, missense
rs717105 -- 153,182,370(+) GCCTG(C/T)TGCCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MAGEA1 Gene

Variant ID Type Subtype PubMed ID
nsv7467 OTHER Inversion 18451855
dgv2494e1 CNV Complex 17122850
esv33199 CNV Gain+Loss 17666407
nsv9998 CNV Gain 18304495
dgv270e55 CNV Gain 17911159
nsv218 OTHER Inversion 15895083
dgv2n30 CNV Gain 18288195

Variation tolerance for MAGEA1 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAGEA1 Gene

Disorders for MAGEA1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MAGEA1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
hemangioma of liver
  • angioma of liver
lung cancer
  • lung cancer, protection against
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
dyskeratosis congenita
  • revesz syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAGEA1

Genetic Association Database (GAD)
MAGEA1
Human Genome Epidemiology (HuGE) Navigator
MAGEA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAGEA1
genes like me logo Genes that share disorders with MAGEA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAGEA1 Gene

Publications for MAGEA1 Gene

  1. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. (PMID: 1840703) van der Bruggen P. … Boon T. (Science 1991) 2 3 4 67
  2. Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines. (PMID: 20423514) Zhang S. … Yu Y. (BMC Cancer 2010) 3 23
  3. MAGE-A1 expression is associated with good prognosis in neuroblastoma tumors. (PMID: 18820946) Grau E. … Castel V. (J. Cancer Res. Clin. Oncol. 2009) 3 23
  4. [Expression of melanoma antigen-1, 3 genes in human intrahepatic cholangiocarcinoma and its clinical significance]. (PMID: 18505125) Lu X. … Huang J.F. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2008) 3 23
  5. MAGE-A1, GAGE and NY-ESO-1 cancer/testis antigen expression during human gonadal development. (PMID: 17208940) Gjerstorff M.F. … Ditzel H.J. (Hum. Reprod. 2007) 3 23

Products for MAGEA1 Gene

Sources for MAGEA1 Gene

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